indomethacin has been researched along with Kidney Diseases in 142 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because the cardiovascular system (CVS) side-effects of cyclooxygenase-2 (COX-2) selective inhibitors have recently been questioned, we aimed to compare the renal and haemodynamic effects of cyclooxygenase selective (celecoxib and rofecoxib) and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) (indomethacin) in patients with renal amyloidosis secondary to rheumatological diseases who required anti-inflammatory agents and are taking maximum tolerable dose of angiotensin-converting enzyme inhibitors." | 9.12 | Effect of indomethacin and selective cyclooxygenase-2 inhibitors on proteinuria and renal function in patients with AA type renal amyloidosis. ( Akdag, I; Demircan, C; Dilek, K; Ersoy, A; Gullulu, M; Kahvecioglu, S; Yurtkuran, M, 2006) |
| "To evaluate, for the first time, the efficacy of copper-indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT-116 colorectal cancer cell line, gastrointestinal permeability, mitochondrial oxidative damage, and renal toxicity in rat models." | 7.76 | Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. ( Bonin, AM; Davies, NM; Dillon, CT; Fukuda, C; Hambley, TW; Lay, PA; Teng, XW; Yáñez, JA, 2010) |
| "A case of polyhydramnios was effectively treated with amniotic fluid decompression and indomethacin." | 7.68 | Indomethacin treatment for polyhydramnios and subsequent infantile nephrogenic diabetes insipidus. ( Cotton, DB; Kirshon, B; Smith, LG, 1990) |
| "Individuals receiving lithium carbonate commonly have nephrogenic diabetes insipidus." | 7.68 | Desmopressin and indomethacin therapy for nephrogenic diabetes insipidus in patients receiving lithium carbonate. ( Moses, AM; Weinstock, RS, 1990) |
| " The prostaglandin synthetase inhibitor, indomethacin, rapidly corrected the polyuria both initially and on rechallenge, independent of change in glomerular filtration rate." | 7.67 | Indomethacin in streptozocin-induced nephrogenic diabetes insipidus. ( Bourke, E; de Pertuz, Y; Delaney, V; Nixon, D, 1987) |
| "In four boys with congenital nephrogenic diabetes insipidus, plasma arginine-vasopressin (AVP) and urinary excretion of prostaglandins were studied in response to treatment with hydrochlorothiazide and indomethacin." | 7.67 | Congenital nephrogenic diabetes insipidus-vasopressin and prostaglandins in response to treatment with hydrochlorothiazide and indomethacin. ( Henrichs, IA; Maier, R; Rascher, W; Rosendahl, W; Seyberth, HW, 1987) |
| "Four boys with classical nephrogenic diabetes insipidus have been treated by indomethacin, by hydrochlorothiazide, and by the combination of indomethacin and hydrochlorothiazide." | 7.67 | Response to indomethacin and hydrochlorothiazide in nephrogenic diabetes insipidus. ( Jonkman, A; Monnens, L; Thomas, C, 1984) |
| "Nephrogenic diabetes insipidus (NDI) is a frequent complication in patients receiving long-term lithium therapy." | 7.67 | Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus. ( Allen, HM; Allon, M; Deck, LV; Jackson, RL; Winchester, MD, 1989) |
| "Furosemide treatment increased urine output by 7." | 6.68 | Impaired response to furosemide in hyperprostaglandin E syndrome: evidence for a tubular defect in the loop of Henle. ( Köckerling, A; Reinalter, SC; Seyberth, HW, 1996) |
| "Because the cardiovascular system (CVS) side-effects of cyclooxygenase-2 (COX-2) selective inhibitors have recently been questioned, we aimed to compare the renal and haemodynamic effects of cyclooxygenase selective (celecoxib and rofecoxib) and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) (indomethacin) in patients with renal amyloidosis secondary to rheumatological diseases who required anti-inflammatory agents and are taking maximum tolerable dose of angiotensin-converting enzyme inhibitors." | 5.12 | Effect of indomethacin and selective cyclooxygenase-2 inhibitors on proteinuria and renal function in patients with AA type renal amyloidosis. ( Akdag, I; Demircan, C; Dilek, K; Ersoy, A; Gullulu, M; Kahvecioglu, S; Yurtkuran, M, 2006) |
| " Addition of misoprostol can minimize this renal impairment without affecting pain control." | 5.08 | Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients. ( Dwolatzky, T; Nesher, G; Sonnenblick, M, 1995) |
| "We studied the efficacy of the ACE inhibitor lisinopril in treating overt proteinuria in comparison with the NSAID indomethacin, and evaluated some of the conditions that could influence this antiproteinuric effect." | 5.06 | Efficacy and variability of the antiproteinuric effect of ACE inhibition by lisinopril. ( de Jong, PE; de Zeeuw, D; Heeg, JE; van der Hem, GK, 1989) |
| "Three preterm infants exposed antenatally to indomethacin developed a characteristic syndrome consisting of edema and hydrops with a bleeding disorder at birth, oliguric renal failure during the first 3 postnatal days, and acute pneumoperitoneum resulting from localized ileal perforation(s) at the end of the first week of life." | 4.77 | Oligohydramnios, renal insufficiency, and ileal perforation in preterm infants after intrauterine exposure to indomethacin. ( Coppens, M; Cuvelier, C; de Praeter, C; Dhont, M; Govaert, P; Leroy, JG; Thiery, M; Vanhaesebrouck, P, 1988) |
| "001) than indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes observed in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia, the impairment of kidney functions, and the risks for cardiovascular disease in arthritic rats." | 3.79 | Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis. ( El-Menshawy, O; Ramadan, G, 2013) |
| "To evaluate, for the first time, the efficacy of copper-indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT-116 colorectal cancer cell line, gastrointestinal permeability, mitochondrial oxidative damage, and renal toxicity in rat models." | 3.76 | Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. ( Bonin, AM; Davies, NM; Dillon, CT; Fukuda, C; Hambley, TW; Lay, PA; Teng, XW; Yáñez, JA, 2010) |
| " Although the patient had some clinical similarities to Bartter's syndrome, fractional sodium chloride (NaCl) reabsorption during hypotonic saline diuresis was normal and no clinical amelioration was observed while on indomethacin therapy." | 3.69 | Salt-losing nephropathy associated with inappropriate secretion of atrial natriuretic peptide--a new clinical syndrome. ( Rodríguez-Soriano, J; Vallo, A, 1997) |
| "A case of polyhydramnios was effectively treated with amniotic fluid decompression and indomethacin." | 3.68 | Indomethacin treatment for polyhydramnios and subsequent infantile nephrogenic diabetes insipidus. ( Cotton, DB; Kirshon, B; Smith, LG, 1990) |
| "Individuals receiving lithium carbonate commonly have nephrogenic diabetes insipidus." | 3.68 | Desmopressin and indomethacin therapy for nephrogenic diabetes insipidus in patients receiving lithium carbonate. ( Moses, AM; Weinstock, RS, 1990) |
| "Four boys with classical nephrogenic diabetes insipidus have been treated by indomethacin, by hydrochlorothiazide, and by the combination of indomethacin and hydrochlorothiazide." | 3.67 | Response to indomethacin and hydrochlorothiazide in nephrogenic diabetes insipidus. ( Jonkman, A; Monnens, L; Thomas, C, 1984) |
| "Nephrogenic diabetes insipidus (NDI) is a frequent complication in patients receiving long-term lithium therapy." | 3.67 | Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus. ( Allen, HM; Allon, M; Deck, LV; Jackson, RL; Winchester, MD, 1989) |
| " The prostaglandin synthetase inhibitor, indomethacin, rapidly corrected the polyuria both initially and on rechallenge, independent of change in glomerular filtration rate." | 3.67 | Indomethacin in streptozocin-induced nephrogenic diabetes insipidus. ( Bourke, E; de Pertuz, Y; Delaney, V; Nixon, D, 1987) |
| "In four boys with congenital nephrogenic diabetes insipidus, plasma arginine-vasopressin (AVP) and urinary excretion of prostaglandins were studied in response to treatment with hydrochlorothiazide and indomethacin." | 3.67 | Congenital nephrogenic diabetes insipidus-vasopressin and prostaglandins in response to treatment with hydrochlorothiazide and indomethacin. ( Henrichs, IA; Maier, R; Rascher, W; Rosendahl, W; Seyberth, HW, 1987) |
| "In the patients with renal colic the average resistive index (RI) was significantly greater on the side of the colic after administration of either indomethacin or ketorolac (p<0." | 2.71 | Resistive index in patients with renal colic: differences after medical treatment with indomethacin and ketorolac. ( Bertolotto, M; Calderan, L; Gasparini, C; Pozzi Mucelli, R; Quaia, E, 2003) |
| "Indomethacin treatment was successful in 52 infants (93%)." | 2.71 | High efficacy and minor renal effects of indomethacin treatment during individualized fluid intake in premature infants with patent ductus arteriosus. ( Barth, H; Leonhardt, A; Seyberth, HW; Strehl, R, 2004) |
| "Furosemide treatment increased urine output by 7." | 2.68 | Impaired response to furosemide in hyperprostaglandin E syndrome: evidence for a tubular defect in the loop of Henle. ( Köckerling, A; Reinalter, SC; Seyberth, HW, 1996) |
| " Renal function was assessed in eight patients with chronic renal insufficiency following the administration of flurbiprofen 50 mg as a single dose and after chronic administration of 50 mg four times daily for 8 and 27 days." | 2.67 | Effects of flurbiprofen on renal function in patients with moderate renal insufficiency. ( Brater, DC; Greene, PK; Hall, SD; Manatunga, AK; Murray, MD, 1992) |
| " In conclusion, chronic administration of isoxicam inhibited the renal PG biosynthesis to a similar extent than indomethacin which suggests that non steroidal anti-inflammatory drugs of the oxicam group ought also be used cautiously in patients with renal impairment." | 2.66 | Compared effects of isoxicam and indomethacin on the urinary excretion of prostaglandins in degenerative articular diseases. ( Benzoni, D; Ferry, N; Geoffroy, J; Lejeune, E; Llorca, G; Mathieu, M; Sassard, J, 1989) |
| "The 75% patent ductus arteriosus closure rate with indomethacin treatment in phase 1 was not statistically significant due to a 44% spontaneous closure rate in the control group." | 2.65 | Indomethacin treatment for symptomatic patent ductus arteriosus: a double-blind control study. ( Aziz, KU; Hunt, CE; Newfeld, EA; Wilson, A; Yanagi, RM, 1981) |
| "Pretreatment with capsazepine, CGRP(8-37), indomethacin, and denervation of primary sensory nerves significantly increased blood urea nitrogen and serum creatinine levels, renal vascular permeability, renal tissue levels of myeloperoxidase activity, cytokine-induced neutrophil chemoattractant, and tumor necrosis factor-alpha, and decreased renal tissue blood flow." | 1.35 | Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats. ( Kadoi, Y; Kudo, K; Mizutani, A; Mizutani, S; Murakami, K; Noguchi, T; Okajima, K; Uchino, T, 2009) |
| " Male Wistar rats were pre-treated with zinc sulphate (50 mg/kg) and dosed with indomethacin (20 mg/kg) by oral gavage." | 1.35 | Zinc prevents indomethacin-induced renal damage in rats by ameliorating oxidative stress and mitochondrial dysfunction. ( Faith, M; Jacob, M; Varghese, J, 2009) |
| "Indomethacin was commenced at postnatal age <7 days and >or=7 days in 60 (group 1) and 30 (group 2) neonates, respectively." | 1.33 | Renal impairment associated with indomethacin treatment for patent ductus arteriosus in extremely preterm neonates--is postnatal age at start of treatment important? ( Doherty, DA; Nathan, EA; Patole, SK; Srinivasjois, RM, 2006) |
| "Indomethacin has been reported to cause short-term reduction in glomerular filtration that resolves after cessation of the drug." | 1.32 | Indomethacin and renal impairment in neonates. ( Akima, S; Falk, MC; Gallagher, M; Kent, A; Reynolds, GJ, 2004) |
| " Rats fasted overnight were dosed with indomethacin (20 mg/kg) by gavage and sacrificed 24 hr later." | 1.32 | Indomethacin-induced renal damage: role of oxygen free radicals. ( Balasubramanian, KA; Basivireddy, J; Jacob, M; Pulimood, AB, 2004) |
| "Cadmium (Cd) toxicity was produced in male rats to study the role of cholinoceptors in Cd-induced endothelial dysfunction." | 1.32 | Involvement of cholinoceptors in cadmium-induced endothelial dysfunction. ( Alkan, Z; Bilgen, I; Cirrik, S; Edremitlioğlu, M; Oner, G, 2003) |
| "Reduction of proteinuria is a prerequisite for successful long-term renoprotection." | 1.31 | Role of patient factors in therapy resistance to antiproteinuric intervention in nondiabetic and diabetic nephropathy. ( Andersen, S; Bos, H; De Jong, PE; De Zeeuw, D; Navis, G; Parving, HH; Rossing, P, 2000) |
| "Persistent patent ductus arteriosus was more common in those infants delivered within 48 hours of maternal indomethacin exposure (40% versus 20% (p<0." | 1.30 | Antenatal indomethacin--adverse fetal effects confirmed. ( Baxendale, H; Harding, J; McCowan, L; McLeay, E; O'Donnell, C; Souter, D, 1998) |
| "Only one patient had recurrence of the PDA, and the PDA was closed again in this case without problems using the same regimen." | 1.29 | Treatment of patent ductus arteriosus with low-dose indomethacin in very low birth weight neonates with impairment of renal function: report of three cases. ( Kuo, CY, 1996) |
| "Complete ureteral obstruction was obtained with a Fogarty balloon catheter inflated in the distal ureter; by this method renal pelvic pressure reached 40-50 mm Hg." | 1.28 | Effects of prostaglandins and prostaglandin synthetase inhibitors on acutely obstructed kidneys in the dog. ( Ziegler, M; Zwergel, T; Zwergel, U, 1991) |
| " All marmosets given 12 mg/kg/day and one marmoset given 6 mg/kg/day died during the dosing period (within 20 days)." | 1.28 | Evaluation of the toxicity of indomethacin in a 4-week study, by oral route, in the marmoset (Callithrix jacchus). ( Conz, A; Galli, CL; Giachetti, C; Oberto, G, 1990) |
| "Hyperkalemia is a common and potentially dangerous condition in elderly patients." | 1.27 | Hyperkalemia in the elderly. ( Booth, J; Cain, M; McCarthy, PJ; Walmsley, RN; White, GH, 1984) |
| " Patients with this renal disorder require a permanent high dosed indomethacin therapy." | 1.27 | [The significance of renal prostaglandins for kidney function in early childhood]. ( Seyberth, HW, 1987) |
| " This article attempts to critically review these studies under seven different sections: furosemide pharmacokinetics in normal volunteers, furosemide pharmacokinetics in patients with decreased renal function, furosemide pharmacokinetics in patients with congestive heart failure, furosemide metabolism and assay methods, furosemide bioavailability, dose-response relationships, and the role of inhibitors and mediators on furosemide effects." | 1.26 | Pharmacokinetics/pharmacodynamics of furosemide in man: a review. ( Benet, LZ, 1979) |
| " According to the different elimination mechanisms of the drugs investigated the kinetics was infleunced in different way by the restriction of the renal elimination of these drugs: The half-life periods for the elimination of Metindol, Nevigramon and Mebacid remained unchanged in patients with renal diseases; the half-value period for the elimination of Sulfaclomid was prolonged." | 1.26 | [Studies on the pharmacokinetics of Sulfaclomid, Mebacid, Nevigramon and Metindol in patients with reduced kidney function]. ( Stein, G; Traeger, A, 1978) |
| "Indomethacin did not inhibit the antibacterial effect of gentamycin and, administered alone, it increased the renal concentration ability." | 1.26 | Indomethacin and gentamycin treatment in experimental kidney infection. ( Farkas, E; Petheö, G; Sallai, J; Túri, S, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (54.93) | 18.7374 |
| 1990's | 36 (25.35) | 18.2507 |
| 2000's | 19 (13.38) | 29.6817 |
| 2010's | 9 (6.34) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Helmy, MW | 1 |
| Helmy, MM | 1 |
| El-Mas, MM | 1 |
| Koc, K | 1 |
| Cerig, S | 1 |
| Ozek, NS | 1 |
| Aysin, F | 1 |
| Yildirim, S | 1 |
| Cakmak, O | 1 |
| Hosseinigouzdagani, M | 1 |
| Geyikoglu, F | 1 |
| Ramadan, G | 1 |
| El-Menshawy, O | 1 |
| Westhoff, JH | 1 |
| Giselbrecht, S | 1 |
| Schmidts, M | 1 |
| Schindler, S | 1 |
| Beales, PL | 1 |
| Tönshoff, B | 1 |
| Liebel, U | 1 |
| Gehrig, J | 1 |
| Nagappan, AS | 1 |
| Varghese, J | 2 |
| Pranesh, GT | 1 |
| Jeyaseelan, V | 1 |
| Jacob, M | 3 |
| Bellei, E | 1 |
| Monari, E | 1 |
| Bergamini, S | 1 |
| Cuoghi, A | 1 |
| Tomasi, A | 1 |
| Guerzoni, S | 1 |
| Ciccarese, M | 1 |
| Pini, LA | 1 |
| Bockenhauer, D | 1 |
| Cruwys, M | 1 |
| Kleta, R | 1 |
| Halperin, LF | 1 |
| Wildgoose, P | 1 |
| Souma, T | 1 |
| Nukiwa, N | 1 |
| Cheema-Dhadli, S | 1 |
| Chong, CK | 1 |
| Kamel, KS | 1 |
| Davids, MR | 1 |
| Halperin, ML | 1 |
| Vogt, L | 1 |
| de Zeeuw, D | 4 |
| Woittiez, AJ | 1 |
| Navis, G | 2 |
| Andriessen, P | 1 |
| Struis, NC | 1 |
| Niemarkt, H | 1 |
| Oetomo, SB | 1 |
| Tanke, RB | 1 |
| Van Overmeire, B | 1 |
| Mizutani, A | 1 |
| Okajima, K | 1 |
| Murakami, K | 1 |
| Mizutani, S | 1 |
| Kudo, K | 1 |
| Uchino, T | 1 |
| Kadoi, Y | 1 |
| Noguchi, T | 1 |
| Faith, M | 1 |
| Bonin, AM | 1 |
| Yáñez, JA | 1 |
| Fukuda, C | 1 |
| Teng, XW | 1 |
| Dillon, CT | 1 |
| Hambley, TW | 1 |
| Lay, PA | 1 |
| Davies, NM | 1 |
| Kent, AL | 1 |
| Brown, L | 1 |
| Broom, M | 1 |
| Broomfield, A | 1 |
| Dahlstrom, JE | 1 |
| Guignard, JP | 2 |
| Little, DC | 1 |
| Pratt, TC | 1 |
| Blalock, SE | 1 |
| Krauss, DR | 1 |
| Cooney, DR | 1 |
| Custer, MD | 1 |
| Lee, PR | 1 |
| Kim, SR | 1 |
| Jung, BK | 1 |
| Kim, KR | 1 |
| Chung, JY | 1 |
| Won, HS | 1 |
| Kim, A | 1 |
| Bilgen, I | 1 |
| Oner, G | 1 |
| Edremitlioğlu, M | 1 |
| Alkan, Z | 1 |
| Cirrik, S | 1 |
| Itabashi, K | 1 |
| Ohno, T | 1 |
| Nishida, H | 1 |
| COHEN, T | 1 |
| REAH, TG | 1 |
| Bertolotto, M | 1 |
| Quaia, E | 1 |
| Gasparini, C | 1 |
| Calderan, L | 1 |
| Pozzi Mucelli, R | 1 |
| Akima, S | 1 |
| Kent, A | 1 |
| Reynolds, GJ | 1 |
| Gallagher, M | 1 |
| Falk, MC | 2 |
| Basivireddy, J | 1 |
| Pulimood, AB | 1 |
| Balasubramanian, KA | 1 |
| Leonhardt, A | 1 |
| Strehl, R | 1 |
| Barth, H | 1 |
| Seyberth, HW | 4 |
| Kahvecioglu, S | 1 |
| Dilek, K | 1 |
| Akdag, I | 1 |
| Gullulu, M | 1 |
| Demircan, C | 1 |
| Ersoy, A | 1 |
| Yurtkuran, M | 1 |
| Srinivasjois, RM | 1 |
| Nathan, EA | 1 |
| Doherty, DA | 1 |
| Patole, SK | 1 |
| García García, L | 1 |
| Giménez Llort, A | 1 |
| Camacho Díaz, JA | 1 |
| López Cacho, F | 1 |
| Guardia Sanahuja, E | 1 |
| Monnens, L | 1 |
| Jonkman, A | 1 |
| Thomas, C | 1 |
| Walmsley, RN | 1 |
| White, GH | 1 |
| Cain, M | 1 |
| McCarthy, PJ | 1 |
| Booth, J | 1 |
| Túri, S | 2 |
| Sallai, J | 1 |
| Farkas, E | 1 |
| Petheö, G | 1 |
| de Jong, PE | 6 |
| de Jong-van den Berg, LT | 2 |
| Schouten, H | 2 |
| Donker, AJ | 2 |
| Statius van Eps, LW | 3 |
| Ruilope, L | 1 |
| Bernis, C | 1 |
| Garcia-Robles, R | 1 |
| Alcazar, J | 1 |
| Barrientos, A | 1 |
| Tresguerres, JA | 1 |
| Rodicio, J | 1 |
| Yanagi, RM | 1 |
| Wilson, A | 1 |
| Newfeld, EA | 1 |
| Aziz, KU | 1 |
| Hunt, CE | 1 |
| McDougal, WS | 1 |
| Iwaoka, T | 1 |
| Umeda, T | 1 |
| Nakayama, M | 1 |
| Shimada, T | 1 |
| Fujii, Y | 1 |
| Miura, F | 1 |
| Sato, T | 1 |
| Yeh, TF | 2 |
| Wilks, A | 1 |
| Singh, J | 1 |
| Betkerur, M | 1 |
| Lilien, L | 1 |
| Pildes, RS | 2 |
| Usberti, M | 2 |
| Mileti, M | 1 |
| D'Auria, CG | 1 |
| Dal Canton, A | 1 |
| Romano, C | 1 |
| Copercini, B | 1 |
| Emanuelli, C | 1 |
| Pecchini, F | 1 |
| Oh, W | 1 |
| Blachar, Y | 1 |
| Zadik, Z | 1 |
| Shemesh, M | 1 |
| Kaplan, BS | 1 |
| Levin, S | 1 |
| Yarger, WE | 1 |
| Schocken, DD | 1 |
| Harris, RH | 1 |
| László, A | 1 |
| Mérth, I | 1 |
| Bartter, FC | 1 |
| Epstein, M | 1 |
| Lifschitz, MD | 1 |
| Suzuki, S | 1 |
| Shapiro, R | 1 |
| Mulrow, PJ | 1 |
| Tan, SY | 1 |
| Mertz, DP | 2 |
| Verbaeys, A | 1 |
| Ringoir, S | 1 |
| Praet, M | 1 |
| Van Maele, G | 1 |
| Lameire, N | 1 |
| Nesher, G | 1 |
| Sonnenblick, M | 1 |
| Dwolatzky, T | 1 |
| Duda, SH | 1 |
| Raible, RT | 1 |
| Risler, T | 1 |
| Huppert, PE | 1 |
| Brambs, HJ | 1 |
| Gregor, M | 1 |
| Martinez, EJ | 1 |
| Sinnott, JT | 1 |
| Rodriguez-Paz, G | 1 |
| Oehler, RL | 1 |
| Heyman, SN | 1 |
| Clark, BA | 1 |
| Cantley, L | 1 |
| Spokes, K | 1 |
| Rosen, S | 1 |
| Brezis, M | 1 |
| Epstein, FH | 1 |
| Craig, JC | 1 |
| Köckerling, A | 1 |
| Reinalter, SC | 1 |
| Laerum, E | 1 |
| Ommundsen, OE | 1 |
| Grønseth, JE | 1 |
| Christiansen, A | 1 |
| Fagertun, HE | 1 |
| al-Sahlawi, KS | 1 |
| Tawfik, OM | 1 |
| Ginifer, C | 1 |
| Kelly, AM | 1 |
| Kuo, CY | 1 |
| Romagnoli, C | 1 |
| Zecca, E | 1 |
| Papacci, P | 1 |
| De Carolis, MP | 1 |
| Giannini, R | 1 |
| Gallini, F | 1 |
| Tortorolo, G | 1 |
| Rodríguez-Soriano, J | 1 |
| Vallo, A | 1 |
| Souter, D | 1 |
| Harding, J | 1 |
| McCowan, L | 1 |
| O'Donnell, C | 1 |
| McLeay, E | 1 |
| Baxendale, H | 1 |
| Humphrey, M | 1 |
| King, G | 1 |
| Kang, NS | 1 |
| Yoo, KH | 1 |
| Cheon, H | 1 |
| Choi, BM | 1 |
| Hong, YS | 1 |
| Lee, JW | 1 |
| Kim, SK | 1 |
| Nakada, SY | 1 |
| Jerde, TJ | 1 |
| Bjorling, DE | 1 |
| Saban, R | 1 |
| Bos, H | 1 |
| Andersen, S | 1 |
| Rossing, P | 1 |
| Parving, HH | 1 |
| Wang, YX | 1 |
| Jia, YF | 1 |
| Chen, KM | 1 |
| Morcos, SK | 1 |
| Ohno, Y | 1 |
| Kawanishi, T | 1 |
| Takahashi, A | 1 |
| Omori, Y | 1 |
| Boss, GR | 1 |
| Seegmiller, JE | 1 |
| George, CR | 1 |
| Clark, WF | 1 |
| Cameron, JS | 1 |
| Lindeman, RD | 1 |
| Proctor, RA | 1 |
| Kunin, CM | 1 |
| Benet, LZ | 1 |
| Traeger, A | 2 |
| Stein, G | 2 |
| Horton, R | 1 |
| Zipser, R | 1 |
| Birnbaum, M | 1 |
| Tolot, F | 1 |
| Prost, G | 1 |
| Guignot, B | 1 |
| Pelletier, M | 1 |
| Friedman, WF | 1 |
| Heymann, MA | 1 |
| Rudolph, AM | 1 |
| Kunze, M | 1 |
| Zaumseil, J | 1 |
| Fengler, A | 1 |
| Fröhling, P | 1 |
| Metz, EG | 1 |
| Lindenau, K | 1 |
| Machin, GA | 1 |
| Mihara, M | 1 |
| Ohsugi, Y | 1 |
| Murray, MD | 1 |
| Greene, PK | 1 |
| Brater, DC | 2 |
| Manatunga, AK | 1 |
| Hall, SD | 1 |
| Zwergel, U | 1 |
| Zwergel, T | 1 |
| Ziegler, M | 1 |
| Sacerdoti, D | 1 |
| Borsato, M | 1 |
| Rigotti, P | 1 |
| Amodio, P | 1 |
| Angeli, P | 1 |
| Ferraresso, M | 1 |
| Plebani, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680] | 11,976 participants (Actual) | Interventional | 2016-03-23 | Completed | |||
| Pharmacological Closure of Patent Ductus Arteriosus in Extreme Low Birth Weight Infants. A Comparison of Efficacy, Side Effects and Outcomes Between Indomethacin and Ibuprofen[NCT01758913] | 110 participants (Actual) | Interventional | 2007-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 189 |
| Placebo Arm | 230 |
- Birth weight <2500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1078 |
| Placebo Arm | 1153 |
- Birth weight <1500g (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 78 |
| Placebo Arm | 101 |
- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 303 |
| Placebo Arm | 353 |
- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 134 |
| Placebo Arm | 152 |
- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 141 |
| Placebo Arm | 166 |
- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 42 |
| Placebo Arm | 30 |
- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 352 |
| Placebo Arm | 325 |
- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 264 |
| Placebo Arm | 309 |
The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 668 |
| Placebo Arm | 754 |
- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 1506 |
| Placebo Arm | 1564 |
- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 214 |
| Placebo Arm | 246 |
- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 26 |
| Placebo Arm | 25 |
- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 54 |
| Placebo Arm | 43 |
- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 9 |
| Placebo Arm | 12 |
- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 23 |
| Placebo Arm | 30 |
Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 290 |
| Placebo Arm | 333 |
Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| Intervention Arm | 8 |
| Placebo Arm | 21 |
11 reviews available for indomethacin and Kidney Diseases
| Article | Year |
|---|---|
Patent ductus arteriosus in micropreemies and full-term infants: the relative merits of surgical ligation versus indomethacin treatment.
Topics: Ductus Arteriosus, Patent; Female; Gestational Age; Hemorrhage; Humans; Indomethacin; Infant, Newbor | 2003 |
[Review of pseudohypoaldosteronism. Apropos of a clinical case in a 2-month-old girl].
Topics: Age Factors; Diagnosis, Differential; Endocrine System Diseases; Female; Growth Disorders; Humans; H | 1984 |
Hyperuricemia and gout. Classification, complications and management.
Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Human | 1979 |
The role of platelets in glomerulonephritis.
Topics: Adenosine; Antidepressive Agents; Aspirin; Blood Platelets; Complement System Proteins; Endothelium; | 1975 |
[Kidney and pregnancy].
Topics: Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Chloramphenicol; Creatin | 1976 |
[Multiple manifestations of intolerance in association with anti-inflammatory agents. Role of phenylbutazone].
Topics: Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug Tolera | 1976 |
[The role of non steroidal anti-inflammatory agents in the treatment of renal colic].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Humans; Indomethacin; Ketoprofen; Kidney | 1989 |
Non-steroidal and analgesic therapy in the elderly.
Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen | 1986 |
Oligohydramnios, renal insufficiency, and ileal perforation in preterm infants after intrauterine exposure to indomethacin.
Topics: Amniotic Fluid; Female; Gastrointestinal Hemorrhage; Humans; Ileal Diseases; Indomethacin; Infant, L | 1988 |
Sickle cell nephropathy: new insights into its pathophysiology.
Topics: Aldosterone; Anemia, Sickle Cell; Hemodynamics; Humans; Indomethacin; Kidney Diseases; Kidney Medull | 1985 |
[Current status of nephrology].
Topics: Acute Kidney Injury; Angiotensin II; Anti-Bacterial Agents; Antilymphocyte Serum; Humans; Immunizati | 1968 |
19 trials available for indomethacin and Kidney Diseases
| Article | Year |
|---|---|
Selective cyclooxygenase-2 (COX-2) inhibition reduces proteinuria in renal patients.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Bloo | 2009 |
Resistive index in patients with renal colic: differences after medical treatment with indomethacin and ketorolac.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Colic; Humans; Indomethacin; Ketorolac; Kidn | 2003 |
High efficacy and minor renal effects of indomethacin treatment during individualized fluid intake in premature infants with patent ductus arteriosus.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Administration Schedule; Ductus Arteriosus, Patent; Ec | 2004 |
Effect of indomethacin and selective cyclooxygenase-2 inhibitors on proteinuria and renal function in patients with AA type renal amyloidosis.
Topics: Adult; Amyloidosis; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Female; Humans; Indometh | 2006 |
Indomethacin treatment for symptomatic patent ductus arteriosus: a double-blind control study.
Topics: Clinical Trials as Topic; Double-Blind Method; Ductus Arteriosus, Patent; Gastrointestinal Hemorrhag | 1981 |
Furosemide prevents the renal side effects of indomethacin therapy in premature infants with patent ductus arteriosus.
Topics: Drug Therapy, Combination; Ductus Arteriosus, Patent; Furosemide; Humans; Indomethacin; Infant, Newb | 1982 |
Protective effect of misoprostol on indomethacin induced renal dysfunction in elderly patients.
Topics: Aged; Aging; Drug Therapy, Combination; Female; Hospitalization; Humans; Indomethacin; Kidney Diseas | 1995 |
Impaired response to furosemide in hyperprostaglandin E syndrome: evidence for a tubular defect in the loop of Henle.
Topics: Bartter Syndrome; Dinoprostone; Diuretics; Furosemide; Humans; Indomethacin; Kidney Diseases; Loop o | 1996 |
Intramuscular diclofenac versus intravenous indomethacin in the treatment of acute renal colic.
Topics: Acute Disease; Adult; Analgesics, Opioid; Colic; Cyclooxygenase Inhibitors; Diclofenac; Female; Huma | 1996 |
Comparative study of the efficacy of lysine acetylsalicylate, indomethacin and pethidine in acute renal colic.
Topics: Adult; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colic; Doub | 1996 |
Administration of rectal indomethacin does not reduce the requirement for intravenous narcotic analgesia in acute renal colic.
Topics: Acute Disease; Administration, Rectal; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 1996 |
Furosemide does not prevent indomethacin-induced renal side effects in preterm infants.
Topics: Body Weight; Cyclooxygenase Inhibitors; Diuretics; Ductus Arteriosus, Patent; Female; Furosemide; Ge | 1997 |
Effects of flurbiprofen on renal function in patients with moderate renal insufficiency.
Topics: Aged; Blood Pressure; Body Weight; Female; Flurbiprofen; Hemodynamics; Humans; Indomethacin; Kidney; | 1992 |
Treatment of renal colic by prostaglandin synthetase inhibitors and avafortan (analgesic antispasmodic).
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Dipyrone; | 1990 |
Efficacy and variability of the antiproteinuric effect of ACE inhibition by lisinopril.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Diet, Sodium-Restricted; Enalapril; | 1989 |
Compared effects of isoxicam and indomethacin on the urinary excretion of prostaglandins in degenerative articular diseases.
Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Dinoprost; Double- | 1989 |
Rectal v. intravenous administration of indomethacin in the treatment of renal colic.
Topics: Adult; Clinical Trials as Topic; Colic; Double-Blind Method; Female; Humans; Indomethacin; Injection | 1988 |
Intravenous indomethacin and oxycone-papaverine in the treatment of acute renal colic. A double-blind study.
Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Codeine; Colic; Double-Blind Method; Drug Comb | 1987 |
[Indomethacin the treatment of glomerular nephropathies].
Topics: Adult; Child; Clinical Trials as Topic; Evaluation Studies as Topic; Glomerulonephritis; Humans; Ind | 1973 |
112 other studies available for indomethacin and Kidney Diseases
| Article | Year |
|---|---|
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Enhanced lipoxygenase/LTD4 signaling accounts for the exaggerated hypertensive and nephrotoxic effects of cyclosporine plus indomethacin in rats.
Topics: Animals; Blood Pressure; Cyclosporine; Drug Interactions; Hypertension; Indomethacin; Kidney; Kidney | 2018 |
The efficacy of oleuropein against non-steroidal anti-inflammatory drug induced toxicity in rat kidney.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Indomethacin; Iridoid Glucosides; Ir | 2019 |
Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Atherosclerosis; | 2013 |
Development of an automated imaging pipeline for the analysis of the zebrafish larval kidney.
Topics: Animals; Automation; Disease Models, Animal; Embryo, Nonmammalian; Gene Knockdown Techniques; Humans | 2013 |
Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage.
Topics: Administration, Oral; Animals; Blotting, Western; Cyclooxygenase Inhibitors; Electrophoresis, Polyac | 2014 |
Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chronic Disea | 2015 |
Antenatal Bartter's syndrome: why is this not a lethal condition?
Topics: Animals; Aquaporin 1; Bartter Syndrome; Chlorides; Diabetes Insipidus, Nephrogenic; Humans; Hyperald | 2008 |
Furosemide in preterm infants treated with indomethacin for patent ductus arteriosus.
Topics: Cohort Studies; Creatinine; Cyclooxygenase Inhibitors; Diuretics; Ductus Arteriosus, Patent; Female; | 2009 |
Activation of sensory neurons reduces ischemia/reperfusion-induced acute renal injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calci | 2009 |
Zinc prevents indomethacin-induced renal damage in rats by ameliorating oxidative stress and mitochondrial dysfunction.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Enzymes; Humans; Indomethacin; Kidne | 2009 |
Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats.
Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Carcinogens; | 2010 |
Increased urinary podocytes following indomethacin suggests drug-induced glomerular injury.
Topics: Anti-Bacterial Agents; Cardiovascular Agents; Drug Therapy, Combination; Ductus Arteriosus, Patent; | 2012 |
The adverse renal effects of prostaglandin-synthesis inhibitors in the newborn rabbit.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Cycloox | 2002 |
Therapeutic effect of cyclo-oxygenase inhibitors with different isoform selectivity in lipopolysaccharide-induced preterm birth in mice.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Femal | 2003 |
Involvement of cholinoceptors in cadmium-induced endothelial dysfunction.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Thoracic; Atropine; Cadmium; Calcimycin; Dose-R | 2003 |
Indomethacin responsiveness of patent ductus arteriosus and renal abnormalities in preterm infants treated with indomethacin.
Topics: Cardiovascular Agents; Chorioamnionitis; Ductus Arteriosus, Patent; Echocardiography, Doppler; Femal | 2003 |
Nephropathy associated with the oral administration of zoxazolamine (flexin); report of a case.
Topics: Administration, Oral; Humans; Indomethacin; Kidney; Kidney Diseases; Muscle Relaxants, Central; Zoxa | 1957 |
GOUT.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Colchicine; Diagnosis, Differential; Diet; Diet | 1964 |
Indomethacin and renal impairment in neonates.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Birth Weight; Creatinine; Ductus Arteriosus, Patent; Female | 2004 |
Indomethacin-induced renal damage: role of oxygen free radicals.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Free Radicals; Indomethacin; Kidney Diseases; Male | 2004 |
Renal impairment associated with indomethacin treatment for patent ductus arteriosus in extremely preterm neonates--is postnatal age at start of treatment important?
Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Ductus Arteriosus, Patent; Female; | 2006 |
Response to indomethacin and hydrochlorothiazide in nephrogenic diabetes insipidus.
Topics: Child; Diabetes Insipidus; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Indomethacin; Inf | 1984 |
Hyperkalemia in the elderly.
Topics: Aged; Amiloride; Diagnosis, Differential; Electrolytes; Endocrine System Diseases; Female; Humans; H | 1984 |
Drugs and the neonatal kidney.
Topics: Asphyxia Neonatorum; Captopril; Gentamicins; Humans; Hypoxia; Indomethacin; Infant, Newborn; Infant, | 1982 |
Indomethacin and gentamycin treatment in experimental kidney infection.
Topics: Animals; Antibodies, Bacterial; Drug Therapy, Combination; Escherichia coli Infections; Female; Gent | 1982 |
The influence of indomethacin on renal acidification in normal subjects and in patients with sickle cell anemia.
Topics: Acidosis; Adolescent; Adult; Anemia, Sickle Cell; Female; Humans; Indomethacin; Kidney Diseases; Kid | 1983 |
Urinary prostaglandin E2 in chronic renal disease.
Topics: Adolescent; Adult; Chronic Disease; Dinoprostone; Female; Humans; Indomethacin; Kidney Diseases; Mal | 1981 |
Pharmacologic preservation of renal mass and function in obstructive uropathy.
Topics: Animals; Captopril; Indomethacin; Kidney; Kidney Diseases; Male; Organ Size; Proline; Rats; Ureteral | 1982 |
A case of membranous nephropathy associated with thyroid antigens.
Topics: Antigens; Chemical and Drug Induced Liver Injury; Chronic Disease; Female; Humans; Hypothyroidism; I | 1982 |
The influence of indomethacin on renal concentrating and diluting capacity in sickle cell nephropathy.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Creatinine; Glomerular Filtration Rate; Humans; Indomethacin | 1982 |
Reversal of proximal tubular dysfunction by indomethacin.
Topics: Humans; Indomethacin; Kidney Diseases; Kidney Tubules, Proximal; Male; Middle Aged | 1982 |
Renal functions and clinical disorders in the neonate.
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Asphyxia Neonatorum; Furosemide; Humans; Indomethacin; I | 1981 |
The effect of inhibition of prostaglandin synthesis on free water and osmolar clearances in patients with hereditary nephrogenic diabetes insipidus.
Topics: Adolescent; Child; Chlorothiazide; Diabetes Insipidus; Drug Combinations; Humans; Indomethacin; Kidn | 1980 |
Obstructive nephropathy in the rat: possible roles for the renin-angiotensin system, prostaglandins, and thromboxanes in postobstructive renal function.
Topics: Angiotensin II; Animals; Imidazoles; Indomethacin; Kidney Diseases; Male; Prostaglandins; Rats; Reni | 1980 |
[Indomethacin therapy of children with nephrogenic diabetes insipidus].
Topics: Acidosis, Renal Tubular; Child; Child, Preschool; Diabetes Insipidus; Diuresis; Female; Humans; Indo | 1980 |
Role of prostaglandins in potassium-depletion nephropathy.
Topics: Animals; Bartter Syndrome; Blood; Desoxycorticosterone; Dogs; Female; Hyperaldosteronism; Indomethac | 1980 |
Volume status as a determinant of the influence of renal PGE on renal function.
Topics: Humans; Indomethacin; Kidney; Kidney Diseases; Prostaglandins E; Regional Blood Flow; Sodium | 1980 |
Urinary prostaglandin E2 excretion in chronic renal disease.
Topics: Chronic Disease; Female; Humans; Hypertension, Renal; Indomethacin; Kidney Diseases; Prostaglandins | 1980 |
[Gout as a joint disease and as a generalized disease. Incidence, diagnosis and therapy].
Topics: Allopurinol; Colchicine; Diabetes Complications; Gout; Humans; Hypertension; Indomethacin; Kidney Di | 1980 |
Contrast media injection in the rat after multiple renal insults. No evidence of additional nephrotoxicity.
Topics: Analysis of Variance; Animals; Contrast Media; Creatinine; Indomethacin; Injections; Kidney Diseases | 1995 |
[Therapeutic bilateral renal artery embolization in the nephrotic syndrome].
Topics: Amyloidosis; Captopril; Cardiomyopathies; Contraindications; Creatinine; Crohn Disease; Drug Therapy | 1994 |
Lithium-induced nephrogenic diabetes insipidus treated with indomethacin.
Topics: Acute Disease; Aged; Diabetes Insipidus; Humans; Indomethacin; Kidney Diseases; Lithium Carbonate; M | 1993 |
Effects of ioversol versus iothalamate on endothelin release and radiocontrast nephropathy.
Topics: Animals; Cattle; Cells, Cultured; Contrast Media; Endothelins; Endothelium, Vascular; In Vitro Techn | 1993 |
Indomethacin for renal impairment in neonatal Bartter's syndrome.
Topics: Bartter Syndrome; Child, Preschool; Female; Glomerular Filtration Rate; Humans; Indomethacin; Kidney | 1996 |
Treatment of patent ductus arteriosus with low-dose indomethacin in very low birth weight neonates with impairment of renal function: report of three cases.
Topics: Adult; Blood Urea Nitrogen; Contraindications; Creatinine; Ductus Arteriosus, Patent; Female; Gestat | 1996 |
Salt-losing nephropathy associated with inappropriate secretion of atrial natriuretic peptide--a new clinical syndrome.
Topics: Aldosterone; Atrial Natriuretic Factor; Blood Volume; Child; Cyclooxygenase Inhibitors; Electrocardi | 1997 |
Antenatal indomethacin--adverse fetal effects confirmed.
Topics: Cerebral Hemorrhage; Ductus Arteriosus, Patent; Female; Fetal Diseases; Humans; Indomethacin; Infant | 1998 |
Re: The debate regarding the risks of tocolytic agents.
Topics: Cerebral Hemorrhage; Ductus Arteriosus, Patent; Female; Fetal Diseases; Humans; Indomethacin; Kidney | 1998 |
Indomethacin treatment decreases renal blood flow velocity in human neonates.
Topics: Birth Weight; Blood Flow Velocity; Creatinine; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; | 1999 |
Selective cyclooxygenase-2 inhibitors reduce ureteral contraction in vitro: a better alternative for renal colic?
Topics: Animals; Colic; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Humans; In Vitro Techniques; Indometh | 2000 |
Role of patient factors in therapy resistance to antiproteinuric intervention in nondiabetic and diabetic nephropathy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Diabetic Nephropa | 2000 |
Radiographic contrast media induced nephropathy: experimental observations and the protective effect of calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Chromium; Contrast Media; Diatrizoate; Diltiazem; Dose-Response R | 2001 |
[Biochemical studies of chemically induced renal damage. II) Changes or urinary enzyme activities induced by indomethacin and phenylbutazone (author's transl)].
Topics: Acetylglucosaminidase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; gamma-Glutamyltra | 1979 |
Drug treatment of the chronic idiopathic glomerulopathies.
Topics: Adrenal Cortex Hormones; Alkylating Agents; B-Lymphocytes; Chronic Disease; Dipyridamole; Folic Acid | 1977 |
Salicylate-induced enzymuria: comparison with other anti-inflammatory agents.
Topics: Acetaminophen; Acetylglucosaminidase; Adult; Anti-Inflammatory Agents; Aspirin; Gold; Hexosaminidase | 1978 |
Pharmacokinetics/pharmacodynamics of furosemide in man: a review.
Topics: Biological Availability; Dose-Response Relationship, Drug; Drug Interactions; Furosemide; Heart Fail | 1979 |
[Studies on the pharmacokinetics of Sulfaclomid, Mebacid, Nevigramon and Metindol in patients with reduced kidney function].
Topics: Creatine; Humans; Indomethacin; Kidney; Kidney Diseases; Nalidixic Acid; Pyrimidines; Sulfamerazine; | 1978 |
Prostaglandins: renin release and renal function.
Topics: Animals; Bartter Syndrome; Dogs; Homeostasis; Humans; Indomethacin; Ischemia; Kallikreins; Kidney; K | 1978 |
Commentary: new thoughts on an old problem--patent ductus arteriosus in the premature infant.
Topics: Dose-Response Relationship, Drug; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; | 1977 |
[Pharmacokinetics of indomethacin and indomethacin metabolites administered continuously to patients with healthy or damaged kidneys].
Topics: Half-Life; Humans; Indomethacin; Kidney Diseases; Kinetics; Time Factors | 1977 |
[Experiences in a nephrological dispensatory care].
Topics: Ambulatory Care; Azathioprine; Cyclophosphamide; Glomerulonephritis; Humans; Indomethacin; Kidney Di | 1975 |
Fetal indomethacin exposure and renal dysgenesis.
Topics: Female; Fetofetal Transfusion; Fetus; Humans; Indomethacin; Kidney Diseases; Pregnancy; Twins, Monoz | 1992 |
Autoimmune kidney disease in MRL/lpr mice inhibited by OK-432; II. Effect of indomethacin.
Topics: Animals; Antibodies, Antinuclear; Antigen-Antibody Complex; Autoimmune Diseases; Dinoprostone; Disea | 1992 |
Effects of prostaglandins and prostaglandin synthetase inhibitors on acutely obstructed kidneys in the dog.
Topics: Acute Disease; Animals; Blood Pressure; Colic; Dinoprost; Dinoprostone; Dipyrone; Dogs; Female; Indo | 1991 |
Increased renal production of cytochrome P450-dependent metabolites of arachidonic acid in cyclosporine-induced nephrotoxicity.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclosporins; Cytochrome P-450 Enzyme System; Indometh | 1991 |
The role of prostaglandins in NSAID induced renal dysfunction.
Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Clinical Trials as Topic; G | 1991 |
Ornithine decarboxylase induction in mouse kidney as indicator of renal damage. Differential nephrotoxic effect of anticancer antifolate drugs.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers; Enzyme Induction; Female; Folic Acid; Folic Ac | 1991 |
Oral indomethacin for acute renal colic.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Colic; Humans; Indomethacin; Kidney Di | 1991 |
Nephrogenic diabetes insipidus responsive to indomethacin plus dDAVP.
Topics: Deamino Arginine Vasopressin; Diabetes Insipidus; Drug Therapy, Combination; Female; Humans; Indomet | 1991 |
Treatment of polyhydramnios with indomethacin.
Topics: Adult; Female; Humans; Indomethacin; Kidney Diseases; Polyhydramnios; Pregnancy; Tocolysis | 1991 |
[Does furosemide prevent changes in renal function induced by administration of indomethacin in premature infants?].
Topics: Furosemide; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Kidney Diseases | 1990 |
Evaluation of the toxicity of indomethacin in a 4-week study, by oral route, in the marmoset (Callithrix jacchus).
Topics: Administration, Oral; Animals; Blood Cell Count; Blood Chemical Analysis; Body Weight; Callithrix; F | 1990 |
The effect of indomethacin and metamizole on ureteral motility and urine flow in sheep.
Topics: Animals; Colic; Dipyrone; Dose-Response Relationship, Drug; Female; Indomethacin; Kidney Diseases; M | 1990 |
Desmopressin and indomethacin therapy for nephrogenic diabetes insipidus in patients receiving lithium carbonate.
Topics: Adult; Antiviral Agents; Deamino Arginine Vasopressin; Diabetes Insipidus; Drug Evaluation; Drug Syn | 1990 |
Indomethacin treatment for polyhydramnios and subsequent infantile nephrogenic diabetes insipidus.
Topics: Adult; Diabetes Insipidus; Female; Humans; Indomethacin; Infant, Newborn; Kidney Diseases; Polyhydra | 1990 |
Autacoid modulation and N-(3,5-dichlorophenyl)succinimide nephrotoxicity.
Topics: Animals; Creatinine; Fungicides, Industrial; Hemodynamics; Imidazoles; Indomethacin; Kidney; Kidney | 1990 |
Effect of indomethacin on unilateral obstructed renal pelvis and on ureteral peristalsis. Experimental study in awake sheep.
Topics: Abdomen; Animals; Consciousness; Constriction, Pathologic; Indomethacin; Kidney Diseases; Kidney Pel | 1990 |
[The activity of blood and urinary enzymes in patients with osteoarthrosis deformans and a drug-induced kidney lesion during indomethacin treatment].
Topics: Adult; Clinical Enzyme Tests; Female; Humans; Indomethacin; Kidney; Kidney Diseases; Male; Middle Ag | 1990 |
[Frequency of various types of secondary hypertension and pathogenic mechanisms].
Topics: Adrenal Gland Neoplasms; Cushing Syndrome; Diagnosis, Differential; Glycyrrhetinic Acid; Glycyrrhizi | 1990 |
Hypercalciuric Bartter syndrome: resolution of nephrocalcinosis with indomethacin.
Topics: Bartter Syndrome; Calcinosis; Calcium Metabolism Disorders; Humans; Hyperaldosteronism; Indomethacin | 1989 |
Renal effects of indomethacin in patients with systemic lupus erythematosus.
Topics: Adult; Aldosterone; Female; Glomerular Filtration Rate; Humans; Indomethacin; Kidney Diseases; Lupus | 1989 |
Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus.
Topics: Adult; Diabetes Insipidus; Female; Humans; Indomethacin; Kidney Diseases; Lithium; Polyuria | 1989 |
Indomethacin therapy in premature infants with patent ductus arteriosus--determination of therapeutic plasma levels.
Topics: Ductus Arteriosus, Patent; Half-Life; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Dise | 1989 |
Indomethacin in streptozocin-induced nephrogenic diabetes insipidus.
Topics: Administration, Oral; Adolescent; Diabetes Insipidus; Drug Evaluation; Female; Glomerular Filtration | 1987 |
Congenital nephrogenic diabetes insipidus-vasopressin and prostaglandins in response to treatment with hydrochlorothiazide and indomethacin.
Topics: Child; Child, Preschool; Diabetes Insipidus; Humans; Hydrochlorothiazide; Indomethacin; Infant; Kidn | 1987 |
[Contribution of animal experiments in the problem of a long-term indomethacin therapy in advanced nephron loss].
Topics: Animals; Female; Glomerular Filtration Rate; Indomethacin; Kidney; Kidney Diseases; Mice; Nephrectom | 1988 |
Hypocalcaemia and indomethacin.
Topics: Aged; Aged, 80 and over; Humans; Hypocalcemia; Indomethacin; Kidney Diseases; Male | 1986 |
Additive renal effects of indomethacin and dipyridamole in man.
Topics: Adenosine; Adolescent; Adult; Body Water; Dipyridamole; Diuresis; Drug Interactions; Female; Glomeru | 1987 |
[The significance of renal prostaglandins for kidney function in early childhood].
Topics: Angiotensin II; Aspirin; Child, Preschool; Creatinine; Ductus Arteriosus, Patent; Glomerular Filtrat | 1987 |
[Treatment of renal colic with indomethacin].
Topics: Administration, Oral; Adult; Aged; Colic; Drug Evaluation; Female; Humans; Indomethacin; Injections, | 1986 |
Renal hemodynamic effects of therapeutic plasma levels of sulindac sulfide during hemorrhage.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dogs; Glome | 1986 |
[Indomethacin and furosemide in closure of ductus arteriosus].
Topics: Drug Evaluation; Ductus Arteriosus, Patent; Female; Furosemide; Humans; Indomethacin; Infant, Newbor | 1986 |
Mechanism of action of indomethacin in tubular defects.
Topics: Adolescent; Aldosterone; Child; Child, Preschool; Diabetes Insipidus; Dinoprostone; Fanconi Anemia; | 1985 |
Motility of the human ureter, with special reference to the effect of indomethacin.
Topics: Dinoprost; Dinoprostone; Humans; In Vitro Techniques; Indomethacin; Kidney Diseases; Muscle Contract | 1985 |
Indomethacin for nephrogenic diabetes insipidus in a four-week-old infant.
Topics: Diabetes Insipidus; Female; Humans; Indomethacin; Infant, Newborn; Kidney Diseases; Time Factors | 1986 |
Familial nephropathic amyloidosis associated with indomethacin responsive fever.
Topics: Amyloidosis; Female; Fever; Genes, Dominant; Humans; Indomethacin; Kidney Diseases; Middle Aged | 1985 |
[Clinical observation of indomethacin suppository for renal colic].
Topics: Adult; Aged; Colic; Female; Humans; Indomethacin; Kidney Diseases; Male; Middle Aged; Suppositories; | 1985 |
[Drugs and gastric hemorrhage. Results of 1 year's prospective study].
Topics: Alcoholic Beverages; Anticoagulants; Blood Transfusion; Cortisone; Drug Therapy, Combination; Gastro | 1974 |
[Current status of modern nephrology].
Topics: Adult; Biopsy; Female; Germany, East; Glomerulonephritis; Humans; Immunosuppressive Agents; Indometh | 1972 |
[Immunosuppressive therapy in renal insufficiency].
Topics: Adrenal Cortex Hormones; Animals; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Indom | 1972 |
The binding of urate to plasma proteins.
Topics: Allopurinol; Aspirin; Binding Sites; Blood Proteins; Colchicine; Dialysis; Evaluation Studies as Top | 1974 |
[Special problems of juvenile rheumatoid arthritis].
Topics: Adrenal Cortex Hormones; Amyloidosis; Arthritis, Juvenile; Bone Development; Child; Chloroquine; Dia | 1974 |
Progress in nephrology, renal dialysis and transplantation.
Topics: Analgesics; Antilymphocyte Serum; Bile Acids and Salts; Cephaloridine; Diet Therapy; Glomerulonephri | 1970 |
[Treatment of nephropathy in gout].
Topics: Allopurinol; Citrates; Colchicine; Gout; Humans; Indomethacin; Kidney Calculi; Kidney Diseases; Neph | 1972 |
An extended study of indomethacin. I. Clinical pharmacology.
Topics: Adult; Aged; Arthritis; Central Nervous System Diseases; Fibromyalgia; Gastrointestinal Diseases; He | 1966 |
[Visceral lupus erythematosus].
Topics: Antigen-Antibody Complex; Antigen-Antibody Reactions; Autoantibodies; Autoimmune Diseases; Diagnosis | 1966 |
Local coagulation in renal disease: the nephrologist's point of view.
Topics: Blood Coagulation; Humans; Indomethacin; Kidney Diseases | 1971 |
[Gout from the view of a special hospital for rheumatic patients].
Topics: Acute Disease; Adolescent; Adult; Aged; Austria; Child; Cholesterol; Colchicine; Colic; Diabetes Com | 1971 |
[Indomethacin in nephropathies in children. Apropos of 21 cases].
Topics: Adolescent; Child; Child, Preschool; Glomerulonephritis; Humans; Indomethacin; Kidney Diseases; Prot | 1971 |
Etiology and treatment of gout--modern concepts.
Topics: Allopurinol; Colchicine; Crystallization; Diagnosis, Differential; Diet Therapy; Gout; Humans; Indom | 1968 |
[Initial experiences on the use of indomethacin in various kidney diseases of infancy].
Topics: Humans; Indomethacin; Infant; Kidney Diseases | 1966 |