indomethacin has been researched along with Jejunal Diseases in 26 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Jejunal Diseases: Pathological development in the JEJUNUM region of the SMALL INTESTINE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We evaluated the role of the pro-inflammatory cytokine TNF-alpha on nitric oxide synthase (NOS) expression in indomethacin-induced jejunoileitis in rats." | 7.76 | TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis. ( Levine, RA; Nandi, J; Saud, B; Yang, ZJ; Zinkievich, JM, 2010) |
| "We investigated the pathogenic role of nitric oxide (NO) in indomethacin-induced intestinal ulceration in rats." | 7.70 | Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats. ( Kato, S; Kunikata, T; Mizoguchi, H; Takeuchi, K; Tanaka, A, 1999) |
| "Jejunal villi undergo early histological shortening and vascular injury in indomethacin-induced ulcerative enteropathy in the rat." | 7.69 | The beta 3-adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat by reversing early villous shortening. ( Anthony, A; Bahl, AK; Dhillon, AP; Oakley, IG; Piasecki, C; Pounder, RE; Spraggs, CF; Trevethick, MA; Wakefield, AJ, 1996) |
| "In indomethacin-induced jejunal ulceration in the rat, villi undergo both early microvascular injury and shortening that may involve activation of villous smooth muscle." | 7.69 | Pre-ulcerative villous contraction and microvascular occlusion induced by indomethacin in the rat jejunum: a detailed morphological study. ( Anthony, A; Dhillon, AP; Pounder, RE; Thrasivoulou, C; Wakefield, AJ, 1995) |
| "Indomethacin induces ulceration in the rat jejunum with sparing of the ileum." | 7.69 | Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 1997) |
| "Four very-low-birth-weight infants developed localized intestinal perforations after enteral administration of indomethacin." | 7.67 | Localized intestinal perforations after enteral administration of indomethacin in premature infants. ( Alpan, G; Amir, G; Eyal, F; Glick, B; Mogle, P; Udassin, R; Vinograd, I, 1985) |
| "β-casofensin exerts protective effects in indomethacin-induced enteritis through preservation of goblet cells and improvement in wound healing." | 3.83 | Protective effects of β-casofensin, a bioactive peptide from bovine β-casein, against indomethacin-induced intestinal lesions in rats. ( Benoit, B; Bessette, C; Bruno, J; Estienne, M; Ferrier, L; Léonil, J; Plaisancié, P; Sekkal, S; Théodorou, V, 2016) |
| " We evaluated the role of the pro-inflammatory cytokine TNF-alpha on nitric oxide synthase (NOS) expression in indomethacin-induced jejunoileitis in rats." | 3.76 | TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis. ( Levine, RA; Nandi, J; Saud, B; Yang, ZJ; Zinkievich, JM, 2010) |
| "The effect of irsogladine maleate, a widely used antiulcer drug in Japan, on indomethacin-induced small intestinal lesions was examined in rats." | 3.74 | Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats. ( Amagase, K; Hatazawa, R; Kamei, K; Kato, N; Kubo, Y; Takeuchi, K, 2008) |
| " We evaluated the relationship between TNF-alpha and iNOS expression in indomethacin-induced jejunoileitis in male Sprague-Dawley rats." | 3.73 | Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression. ( Finocchiaro, S; Levine, RA; Nandi, J; Ong, G; Saud, B, 2005) |
| "Oral indomethacin causes villous shortening, microvascular damage, and distortion, which might induce mucosal ischaemia and necrosis." | 3.70 | Focal reduction of villous blood flow in early indomethacin enteropathy: a dynamic vascular study in the rat. ( Anthony, A; Dhillon, AP; Kelly, DA; Piasecki, C; Pounder, RE; Wakefield, AJ, 1998) |
| "We investigated the pathogenic role of nitric oxide (NO) in indomethacin-induced intestinal ulceration in rats." | 3.70 | Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats. ( Kato, S; Kunikata, T; Mizoguchi, H; Takeuchi, K; Tanaka, A, 1999) |
| "We investigated the effect of dexamethasone on indomethacin-induced ulceration in the rat." | 3.69 | Dexamethasone promotes ulcer plugging in experimental enteritis. ( Anthony, A; Dhillon, AP; Pounder, RE; Sim, R; Wakefield, AJ, 1994) |
| "Jejunal villi undergo early histological shortening and vascular injury in indomethacin-induced ulcerative enteropathy in the rat." | 3.69 | The beta 3-adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat by reversing early villous shortening. ( Anthony, A; Bahl, AK; Dhillon, AP; Oakley, IG; Piasecki, C; Pounder, RE; Spraggs, CF; Trevethick, MA; Wakefield, AJ, 1996) |
| "In indomethacin-induced jejunal ulceration in the rat, villi undergo both early microvascular injury and shortening that may involve activation of villous smooth muscle." | 3.69 | Pre-ulcerative villous contraction and microvascular occlusion induced by indomethacin in the rat jejunum: a detailed morphological study. ( Anthony, A; Dhillon, AP; Pounder, RE; Thrasivoulou, C; Wakefield, AJ, 1995) |
| "Indomethacin induces ulceration in the rat jejunum with sparing of the ileum." | 3.69 | Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 1997) |
| "Four very-low-birth-weight infants developed localized intestinal perforations after enteral administration of indomethacin." | 3.67 | Localized intestinal perforations after enteral administration of indomethacin in premature infants. ( Alpan, G; Amir, G; Eyal, F; Glick, B; Mogle, P; Udassin, R; Vinograd, I, 1985) |
| "Both Crohn's disease ileal ulcers and indomethacin-induced jejunal ulcers in the rat have a predilection for the mesenteric margin of the bowel wall." | 1.31 | Similarities between ileal Crohn's disease and indomethacin experimental jejunal ulcers in the rat. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 2000) |
| "5." | 1.29 | Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin. ( Evans, SM; László, F; Moncada, S; Whittle, BJ, 1995) |
| "Indomethacin treated animals demonstrated significantly less polymorphonuclear leukocyte infiltration and decreased degeneration." | 1.28 | The effect of indomethacin on acute radiation induced gastrointestinal injury: a morphologic study. ( Halter, SA; Rose, PG; Su, CM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.54) | 18.7374 |
| 1990's | 12 (46.15) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Bessette, C | 1 |
| Benoit, B | 1 |
| Sekkal, S | 1 |
| Bruno, J | 1 |
| Estienne, M | 1 |
| Léonil, J | 1 |
| Ferrier, L | 1 |
| Théodorou, V | 1 |
| Plaisancié, P | 1 |
| Nandi, J | 3 |
| Saud, B | 3 |
| Zinkievich, JM | 2 |
| Yang, ZJ | 1 |
| Levine, RA | 3 |
| Harusato, A | 1 |
| Naito, Y | 1 |
| Takagi, T | 1 |
| Yamada, S | 1 |
| Mizushima, K | 1 |
| Hirai, Y | 1 |
| Horie, R | 1 |
| Inoue, K | 1 |
| Fukumoto, K | 1 |
| Hirata, I | 1 |
| Omatsu, T | 1 |
| Kishimoto, E | 1 |
| Uchiyama, K | 1 |
| Handa, O | 1 |
| Ishikawa, T | 1 |
| Kokura, S | 1 |
| Ichikawa, H | 1 |
| Muto, A | 1 |
| Igarashi, K | 1 |
| Yoshikawa, T | 1 |
| Ong, G | 1 |
| Finocchiaro, S | 1 |
| Fujiyama, N | 1 |
| Shitara, Y | 1 |
| Ito, K | 1 |
| Masubuchi, Y | 1 |
| Horie, T | 1 |
| Risty, GM | 1 |
| Najarian, MM | 1 |
| Shapiro, SB | 1 |
| Palma, DT | 1 |
| Marchbank, T | 1 |
| Mahmood, A | 1 |
| Fitzgerald, AJ | 1 |
| Domin, J | 1 |
| Butler, M | 1 |
| Goodlad, RA | 1 |
| Elia, G | 1 |
| Cox, HM | 1 |
| van Heel, DA | 1 |
| Ghosh, S | 1 |
| Playford, RJ | 1 |
| Kamei, K | 1 |
| Kubo, Y | 1 |
| Kato, N | 1 |
| Hatazawa, R | 1 |
| Amagase, K | 1 |
| Takeuchi, K | 2 |
| Venturatos, SG | 1 |
| Hines, C | 1 |
| Blalock, JB | 1 |
| Lu, YF | 1 |
| Mizutani, M | 1 |
| Neya, T | 1 |
| Nakayama, S | 1 |
| Anthony, A | 8 |
| Dhillon, AP | 8 |
| Sim, R | 1 |
| Pounder, RE | 8 |
| Wakefield, AJ | 7 |
| Zalev, AH | 1 |
| Gardiner, GW | 1 |
| Nygard, G | 1 |
| Hudson, M | 1 |
| Piasecki, C | 4 |
| Strong, P | 1 |
| Trevethick, MA | 2 |
| Clayton, NM | 1 |
| Jordan, CC | 1 |
| Whittle, BJ | 1 |
| László, F | 1 |
| Evans, SM | 1 |
| Moncada, S | 1 |
| Bahl, AK | 1 |
| Oakley, IG | 1 |
| Spraggs, CF | 1 |
| Thrasivoulou, C | 1 |
| Kelly, DA | 1 |
| Kelly, D | 1 |
| Tanaka, A | 1 |
| Kunikata, T | 1 |
| Mizoguchi, H | 1 |
| Kato, S | 1 |
| Rose, PG | 1 |
| Halter, SA | 1 |
| Su, CM | 1 |
| Waisman, Y | 1 |
| Zahavi, I | 1 |
| Marcus, H | 1 |
| Ligumsky, M | 1 |
| Rosenbach, Y | 1 |
| Dinari, G | 1 |
| Alpan, G | 1 |
| Eyal, F | 1 |
| Vinograd, I | 1 |
| Udassin, R | 1 |
| Amir, G | 1 |
| Mogle, P | 1 |
| Glick, B | 1 |
1 review available for indomethacin and Jejunal Diseases
| Article | Year |
|---|---|
Multiple indomethacin-induced jejunal ulcerations with perforation: a case report with histology.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethacin; Intestinal Mucosa; Jejunal Di | 2007 |
25 other studies available for indomethacin and Jejunal Diseases
| Article | Year |
|---|---|
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Protective effects of β-casofensin, a bioactive peptide from bovine β-casein, against indomethacin-induced intestinal lesions in rats.
Topics: Administration, Oral; Animals; Caseins; Cattle; Enteritis; HT29 Cells; Humans; Indomethacin; Intesti | 2016 |
TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis.
Topics: Animals; Dose-Response Relationship, Drug; Enteritis; Hyperbaric Oxygenation; Ileitis; Ileum; Indome | 2010 |
Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Basic-Leucine Zipper Transcription Factors; Chemok | 2009 |
Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Down-Regulation; Ileitis; | 2005 |
Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.
Topics: Alanine Transaminase; Animals; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Coloring | 2007 |
5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blotting, Western; Cyclooxygenase Inhi | 2008 |
Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents.
Topics: Animals; Carrier Proteins; Cell Line; Cell Movement; Cell Proliferation; Colitis; Dendritic Cells; D | 2007 |
Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodieste | 2008 |
Ulceration of the small intestine in a patient with celiac disease.
Topics: Aged; Celiac Disease; Diagnosis, Differential; Duodenal Obstruction; Female; Humans; Indomethacin; J | 1984 |
Indomethacin-induced lesion modifies contractile activity in rat small intestines.
Topics: Acetylcholine; Animals; Carbachol; Electric Stimulation; Gastrointestinal Motility; Ileal Diseases; | 1995 |
Dexamethasone promotes ulcer plugging in experimental enteritis.
Topics: Animals; Dexamethasone; Enteritis; Fibrin; Hematologic Tests; Indomethacin; Intestinal Mucosa; Jejun | 1994 |
Drug-induced diaphragmlike small-bowel strictures.
Topics: Female; Humans; Indomethacin; Intestinal Obstruction; Jejunal Diseases; Middle Aged; Radiography | 1994 |
Early histological features of small intestinal injury induced by indomethacin.
Topics: Animals; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Jejunal Diseases; J | 1993 |
Induction of nitric oxide synthase and microvascular injury in the rat jejunum provoked by indomethacin.
Topics: Ampicillin; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Ba | 1995 |
The beta 3-adrenoceptor agonist CL316243 prevents indomethacin-induced jejunal ulceration in the rat by reversing early villous shortening.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dioxoles; Dose-Response | 1996 |
Pre-ulcerative villous contraction and microvascular occlusion induced by indomethacin in the rat jejunum: a detailed morphological study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Intestinal Mucosa; Jejunal Diseases; | 1995 |
Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ileum; Indomethacin; Intestinal Mucosa; Ischemia; | 1997 |
Focal reduction of villous blood flow in early indomethacin enteropathy: a dynamic vascular study in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Indomethacin; Jejunal Diseases; Jejunum; M | 1998 |
Reversal and protection against indomethacin-induced blood stasis and mucosal damage in the rat jejunum by a beta3-adrenoceptor agonist.
Topics: Adrenergic beta-Agonists; Animals; Blood Flow Velocity; Dioxoles; Female; Gastric Mucosa; Hemostasis | 1998 |
Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enzyme Inhibitors; Gene Expression Regulation; Gua | 1999 |
Similarities between ileal Crohn's disease and indomethacin experimental jejunal ulcers in the rat.
Topics: Animals; Crohn Disease; Humans; Ileum; Indomethacin; Intestine, Small; Jejunal Diseases; Male; Mesen | 2000 |
The effect of indomethacin on acute radiation induced gastrointestinal injury: a morphologic study.
Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enteritis; I | 1992 |
Sucralfate is protective against indomethacin-induced intestinal ulceration in the rat.
Topics: Animals; Dinoprostone; Indomethacin; Injections, Subcutaneous; Intestinal Mucosa; Intubation, Gastro | 1988 |
Localized intestinal perforations after enteral administration of indomethacin in premature infants.
Topics: Ductus Arteriosus, Patent; Female; Humans; Ileal Diseases; Indomethacin; Infant, Low Birth Weight; I | 1985 |