Page last updated: 2024-10-29

indomethacin and Itching

indomethacin has been researched along with Itching in 18 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
" Skin biopsy showed eosinophilic folliculitis and there was a rapid response to indomethacin."3.69Pruritic follicular facial rash: eosinophilic folliculitis. ( Kossard, S; Saywell, L, 1997)
"The causes of pruritus are numerous including xerosis, drug and photoeruptions, follicular and papular eruptions as well as infestations and infections by a wide range of organisms."2.68Pruritus in HIV-1 disease: therapy with drugs which may modulate the pattern of immune dysregulation. ( Lee, RB; Skelton, HG; Smith, KJ; Wagner, KF; Yeager, J, 1997)
"Atopic dermatitis is a chronic inflammatory disease characterized by severe pruritus, and cutaneous barrier disruption by scratching contributes to further aggravation of the condition."1.34Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice. ( Arai, I; Futaki, N; Hashimoto, Y; Honma, Y; Nakaike, S; Sakurai, T; Sugimoto, M, 2007)
"Pretreatment of arachidonic acid increased the skin prostaglandins (prostaglandin D2, prostaglandin E2, prostaglandin F2alpha and 6-keto-prostaglandin F1alpha) contents, but indomethacin decreased the prostaglandin D2 and prostaglandin E2 contents."1.32Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. ( Arai, I; Futaki, N; Hashimoto, Y; Inoue, T; Nakaike, S; Sugimoto, M; Takahashi, N; Takano, N, 2004)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19906 (33.33)18.7374
1990's3 (16.67)18.2507
2000's8 (44.44)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Solinski, HJ1
Dranchak, P1
Oliphant, E1
Gu, X1
Earnest, TW1
Braisted, J1
Inglese, J1
Hoon, MA1
Choi, JK1
Kim, KM1
Kim, DK1
Yeom, MH1
Koh, JY1
Jung, SJ1
Kim, HJ1
Oh, SH1
Kim, SY1
Lee, CH1
Zhu, Y1
Wang, XR1
Peng, C1
Xu, JG1
Liu, YX1
Wu, L1
Zhu, QG1
Liu, JY1
Li, FQ1
Pan, YH1
You, BM1
Hu, JH1
Arai, I3
Takano, N1
Hashimoto, Y3
Futaki, N3
Sugimoto, M3
Takahashi, N1
Inoue, T1
Nakaike, S3
Honma, Y2
Tanaka, M1
Fallah, H1
Dunlop, K1
Kossard, S2
Sakurai, T1
Kuraishi, Y2
Ohtsuka, E1
Nakano, T1
Kawai, S1
Andoh, T2
Nojima, H1
Kamimura, K1
Fjellner, B1
Hägermark, O1
Awadzi, K1
Orme, ML1
Breckenridge, AM1
Gilles, HM1
Nishijima, S1
Sugiyama, T1
Nakagawa, M1
Odaka, T1
Takaishi, K1
Saywell, L1
Smith, KJ1
Skelton, HG1
Yeager, J1
Lee, RB1
Wagner, KF1
Katsube, N1
Maruyama, M1
Bigby, M1
Stern, R1
Almeyda, J1
Baker, H1
Caruso, I1
Silberman, HR1
McGinn, TG1
Kremer, WB1

Reviews

2 reviews available for indomethacin and Itching

ArticleYear
Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.
    Journal of the American Academy of Dermatology, 1985, Volume: 12, Issue:5 Pt 1

    Topics: Acetates; Anti-Inflammatory Agents; Aspirin; Drug Eruptions; Humans; Ibuprofen; Indomethacin; ortho-

1985
Drug reactions. XII. Cutaneous reactions to anti-rheumatic drugs.
    The British journal of dermatology, 1970, Volume: 83, Issue:6

    Topics: Adult; Anti-Inflammatory Agents; Drug Eruptions; Edema; Female; Gold; Humans; Indomethacin; Lymphade

1970

Trials

2 trials available for indomethacin and Itching

ArticleYear
The chemotherapy of onchocerciasis VI. The effect of indomethacin and cyproheptadine on the Mazzotti reaction.
    Annals of tropical medicine and parasitology, 1982, Volume: 76, Issue:3

    Topics: Adult; Clinical Trials as Topic; Cyproheptadine; Diethylcarbamazine; Double-Blind Method; Humans; Hy

1982
Pruritus in HIV-1 disease: therapy with drugs which may modulate the pattern of immune dysregulation.
    Dermatology (Basel, Switzerland), 1997, Volume: 195, Issue:4

    Topics: Administration, Cutaneous; Administration, Topical; Anti-Inflammatory Agents; Antipruritics; Cycloox

1997

Other Studies

14 other studies available for indomethacin and Itching

ArticleYear
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
    Science translational medicine, 2019, 07-10, Volume: 11, Issue:500

    Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S

2019
Topical anti-inflammatory and antipruritic effects of Alpinia katsumadai extracts.
    Journal of dermatological science, 2009, Volume: 53, Issue:1

    Topics: Administration, Topical; Alpinia; Animals; Anti-Inflammatory Agents; Antipruritics; Disease Models,

2009
Induction of leukotriene B(4) and prostaglandin E(2) release from keratinocytes by protease-activated receptor-2-activating peptide in ICR mice.
    International immunopharmacology, 2009, Volume: 9, Issue:11

    Topics: Animals; Cetirizine; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Hydroxyurea;

2009
Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis.
    European journal of pharmacology, 2004, Nov-28, Volume: 505, Issue:1-3

    Topics: 6-Ketoprostaglandin F1 alpha; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachid

2004
Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice.
    European journal of pharmacology, 2005, Jul-25, Volume: 518, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinopro

2005
Successful treatment of recalcitrant necrotizing eosinophilic folliculitis using indomethacin and cephalexin.
    The Australasian journal of dermatology, 2006, Volume: 47, Issue:4

    Topics: Administration, Oral; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cephalexin; Di

2006
Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice.
    The British journal of dermatology, 2007, Volume: 156, Issue:6

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;

2007
Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice.
    Journal of pharmacological sciences, 2007, Volume: 105, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Betamethasone Valerate; Bridged Bicyclo Compounds, Heterocycli

2007
Potentiation of histamine-induced itch and flare responses in human skin by the enkephalin analogue FK-33-824, beta-endorphin and morphine.
    Archives of dermatological research, 1982, Volume: 274, Issue:1-2

    Topics: Adolescent; Adult; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dinoprostone; Drug Synerg

1982
Two cases of eosinophilic pustular folliculitis treated by acemetacin.
    The Journal of dermatology, 1994, Volume: 21, Issue:10

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Back; Eosinophilia; Facial Dermatoses; Female; Folli

1994
Pruritic follicular facial rash: eosinophilic folliculitis.
    The Australasian journal of dermatology, 1997, Volume: 38, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Eosinophilia; Facial Dermatoses; Female; Folliculiti

1997
Involvement of leukotriene B(4) in substance P-induced itch-associated response in mice.
    The Journal of investigative dermatology, 2001, Volume: 117, Issue:6

    Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors

2001
[Undesired collateral effects of antirheumatic drugs: indomethacin].
    La Clinica terapeutica, 1972, Feb-29, Volume: 60, Issue:4

    Topics: Arthritis, Rheumatoid; Drug Eruptions; Gastrointestinal Diseases; Headache; Humans; Indomethacin; Pa

1972
Control of fever in Hodgkin's disease by indomethacin.
    JAMA, 1965, Nov-08, Volume: 194, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Antineoplastic Agents; Aspirin; Female; Fever

1965