indomethacin has been researched along with Ischemic Attack, Transient in 25 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Contractions of isolated human pial arteries, induced either by exposition to hemorrhagic cerebrospinal fluid (CSF) from patients with subarachnoid hemorrhage and cerebral vasospasm or by exposition to noradrenaline, were markedly augmented after preincubation of the vessel segments with the cyclooxygenase inhibitor indomethacin, while serotonin-induced contractions were unaffected." | 3.66 | Prostaglandin metabolism and prostacyclin in cerebral vasospasm. ( Andersson, KE; Brandt, L; Hindfelt, B; Ljunggren, B; Uski, T, 1983) |
| "Pretreatment with indomethacin (5 mg/kg iv) markedly reduced postischemia SOD-inhibitable NBT reduction (2." | 1.27 | Postischemic generation of superoxide anion by newborn pig brain. ( Armstead, WM; Busija, DW; Leffler, CW; Mirro, R, 1988) |
| "Aspirin, known to inhibit platelet function markedly, seems to have little effect on isolated vascular smooth muscle." | 1.26 | Cerebral vasospasm: effects of prostaglandin synthetase inhibitors in vitro. ( Chapleau, CE; Robertson, JT; White, RP, 1980) |
| "Pretreatment with indomethacin improved cortical reperfusion but did not influence cortical pO2 and electrocorticographic activity." | 1.26 | Recovery from global cerebral ischemia in rabbits: influence of indomethacin. ( Boulu, RG; Gueniau, C; Plotkine, M; Sofeir, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (68.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chioua, M | 1 |
| Martínez-Alonso, E | 1 |
| Gonzalo-Gobernado, R | 1 |
| Ayuso, MI | 1 |
| Escobar-Peso, A | 1 |
| Infantes, L | 1 |
| Hadjipavlou-Litina, D | 1 |
| Montoya, JJ | 1 |
| Montaner, J | 1 |
| Alcázar, A | 1 |
| Marco-Contelles, J | 1 |
| Zarza, J | 1 |
| Hoehn, BD | 1 |
| Palmer, TD | 1 |
| Steinberg, GK | 1 |
| Brandt, L | 1 |
| Ljunggren, B | 1 |
| Andersson, KE | 1 |
| Hindfelt, B | 1 |
| Uski, T | 1 |
| Awad, I | 1 |
| Little, JR | 1 |
| Lucas, F | 1 |
| Skrinska, V | 1 |
| Slugg, R | 1 |
| Lesser, RP | 1 |
| Fukumori, T | 1 |
| Tani, E | 2 |
| Maeda, Y | 2 |
| Sukenaga, A | 1 |
| Kågström, E | 1 |
| Smith, ML | 1 |
| Wallstedt, L | 1 |
| Siesjö, BK | 1 |
| Mossakowski, MJ | 1 |
| Gajkowska, B | 1 |
| Chapleau, CE | 1 |
| White, RP | 2 |
| Robertson, JT | 2 |
| Dougherty, JH | 1 |
| Levy, DE | 1 |
| Rawlinson, DG | 1 |
| Ruff, R | 1 |
| Weksler, BB | 1 |
| Plum, F | 1 |
| Shohami, E | 1 |
| Rosenthal, J | 1 |
| Lavy, S | 1 |
| Boulu, RG | 1 |
| Gueniau, C | 1 |
| Plotkine, M | 1 |
| Sofeir, M | 1 |
| Miyamoto, T | 1 |
| He, GQ | 1 |
| Zhang, A | 1 |
| Altura, BT | 1 |
| Altura, BM | 1 |
| Louis, TM | 1 |
| Meng, W | 1 |
| Bari, F | 1 |
| Errico, RA | 1 |
| Busija, DW | 2 |
| Kondo, F | 2 |
| Kondo, Y | 2 |
| Gómez-Vargas, M | 1 |
| Ogawa, N | 2 |
| Tong, H | 1 |
| Wood, CE | 1 |
| Makino, H | 1 |
| Gaudet, RJ | 1 |
| Levine, L | 1 |
| Simpson, RK | 1 |
| Fischer, DK | 1 |
| Ehni, BL | 1 |
| Dora, E | 1 |
| Feher, E | 1 |
| Farago, M | 1 |
| Horvath, I | 1 |
| Szabo, C | 1 |
| Armstead, WM | 1 |
| Mirro, R | 1 |
| Leffler, CW | 1 |
| Walker, V | 1 |
| Pickard, JD | 1 |
| Chen, ST | 1 |
| Hsu, CY | 1 |
| Hogan, EL | 1 |
| Halushka, PV | 1 |
| Linet, OI | 1 |
| Yatsu, FM | 1 |
1 review available for indomethacin and Ischemic Attack, Transient
| Article | Year |
|---|---|
Prostaglandins, thromboxane, leukotrienes and the cerebral circulation in health and disease.
Topics: Animals; Arachidonic Acids; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Cerebro | 1985 |
24 other studies available for indomethacin and Ischemic Attack, Transient
| Article | Year |
|---|---|
New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( Z)- N- tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Free Radical Scavengers; Imines; Isch | 2019 |
Major bleeding during combined treatment with indomethacin and low doses of acenocoumarol in a homozygous patient for 2C9*3 variant of cytochrome p-450 CYP2C9.
Topics: Acenocoumarol; Aged; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Cytochrome P-450 CYP2C9; Drug I | 2003 |
Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cell Count; Cell Division; Cell Lineag | 2005 |
Prostaglandin metabolism and prostacyclin in cerebral vasospasm.
Topics: Alprostadil; Epoprostenol; Hemorrhage; Humans; In Vitro Techniques; Indomethacin; Ischemic Attack, T | 1983 |
Modification of focal cerebral ischemia by prostacyclin and indomethacin.
Topics: Animals; Blood-Brain Barrier; Cats; Cell Membrane Permeability; Epoprostenol; Indomethacin; Ischemic | 1983 |
Effects of prostacyclin and indomethacin on experimental delayed cerebral vasospasm.
Topics: Animals; Dogs; Epoprostenol; Indomethacin; Ischemic Attack, Transient; Vasoconstriction; Vasodilatio | 1983 |
Cyclo-oxygenase inhibition by indomethacin and recirculation following cerebral ischemia.
Topics: Animals; Autoradiography; Brain; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Indomethaci | 1983 |
Influence of indomethacin on the ultrastructural pathology of the brain following temporary ischemia in Mongolian gerbils (Meriones unguiculatus).
Topics: Animals; Brain; Female; Gerbillinae; Indomethacin; Ischemic Attack, Transient; Male; Microscopy, Ele | 1984 |
Cerebral vasospasm: effects of prostaglandin synthetase inhibitors in vitro.
Topics: Animals; Arachidonic Acids; Aspirin; Basilar Artery; Cyclooxygenase Inhibitors; Dogs; Female; In Vit | 1980 |
Experimental cerebral ischemia produced by extracranial vascular injury: protection with indomethacin and prostacyclin.
Topics: Animals; Carotid Arteries; Disease Models, Animal; Electroshock; Epoprostenol; Indomethacin; Ischemi | 1982 |
[Thromboxane in rat brain following incomplete ischemia].
Topics: Animals; Cerebral Cortex; Electroencephalography; Indomethacin; Ischemic Attack, Transient; Prostagl | 1982 |
Recovery from global cerebral ischemia in rabbits: influence of indomethacin.
Topics: Animals; Brain Edema; Cerebral Cortex; Indomethacin; Ischemic Attack, Transient; Male; Oxygen Consum | 1981 |
Prostaglandin metabolism in experimental cerebral vasospasm.
Topics: Animals; Chromatography, Thin Layer; Dogs; Indomethacin; Ischemic Attack, Transient; Platelet Aggreg | 1981 |
Cocaine-induced cerebrovasospasm and its possible mechanism of action.
Topics: Animals; Biological Transport; Brain; Calcium; Cells, Cultured; Cocaine; Cyclooxygenase Inhibitors; | 1994 |
Ischemia reduces CGRP-induced cerebral vascular dilation in piglets.
Topics: Animals; Animals, Newborn; Antioxidants; Arterioles; Calcitonin Gene-Related Peptide; Cerebral Arter | 1996 |
Indomethacin inhibits delayed DNA fragmentation of hippocampal CA1 pyramidal neurons after transient forebrain ischemia in gerbils.
Topics: Animals; Cyclooxygenase Inhibitors; DNA Fragmentation; Drug Evaluation, Preclinical; Genetic Techniq | 1998 |
Indomethacin attenuates the cerebral blood flow response to hypotension in late-gestation fetal sheep.
Topics: Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Blood Pressure; Cerebrovascular Circulat | 1999 |
Delayed neuronal death in hippocampal CA1 pyramidal neurons after forebrain ischemia in hyperglycemic gerbils: amelioration by indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Death; Gerbillinae; Hippocampus; H | 2000 |
Transient cerebral ischemia and brain prostaglandins.
Topics: Animals; Brain; Gerbillinae; Indomethacin; Ischemic Attack, Transient; Kinetics; Prostaglandins | 1979 |
Neurogenic hyperthermia in subarachnoid hemorrhage.
Topics: Adult; Combined Modality Therapy; Cyproheptadine; Fever; Humans; Indomethacin; Ischemic Attack, Tran | 1989 |
Mechanism of hemoglobin-induced spasm in the isolated middle cerebral artery of the cat.
Topics: Acetylcholine; Animals; Atropine; Cats; Cerebral Arteries; Dinoprost; Hemoglobins; Indomethacin; Isc | 1989 |
Postischemic generation of superoxide anion by newborn pig brain.
Topics: Animals; Animals, Newborn; Blood Pressure; Brain; Disease Models, Animal; Female; Indomethacin; Isch | 1988 |
Thromboxane, prostacyclin, and leukotrienes in cerebral ischemia.
Topics: Blood Platelets; Diet; Epoprostenol; Indomethacin; Ischemic Attack, Transient; Leukotriene B4; SRS-A | 1986 |
Pharmacodynamic evaluation of human cerebral arteries in the genesis of vasospasm.
Topics: Adult; Angiotensin II; Arginine Vasopressin; Cerebral Arteries; Humans; In Vitro Techniques; Indomet | 1987 |