indomethacin has been researched along with Invasiveness, Neoplasm in 15 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we have investigated the effects of the anti-inflammatory agent indomethacin on the invasion and metabolism of the human breast cancer cell line MDA-MB-435 in Dulbecco's Modified Eagles (DME)-based or Roswell Park Memorial Institute (RPMI)-based cell medium, using a magnetic resonance-compatible invasion assay." | 7.74 | Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line. ( Ackerstaff, E; Artemov, D; Bhujwalla, ZM; Gimi, B, 2007) |
| "Indomethacin and NGX6 inhibit the proliferation and invasiveness of HT-29 and SW620 colon cancer cells by attenuating the WNT/ss-catenin signaling pathway." | 5.35 | Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway. ( Guo, Q; Lian, P; Liao, M; Shen, S; Wang, X; Wu, M; Xiao, Z, 2009) |
| " Here, we have investigated the effects of the anti-inflammatory agent indomethacin on the invasion and metabolism of the human breast cancer cell line MDA-MB-435 in Dulbecco's Modified Eagles (DME)-based or Roswell Park Memorial Institute (RPMI)-based cell medium, using a magnetic resonance-compatible invasion assay." | 3.74 | Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line. ( Ackerstaff, E; Artemov, D; Bhujwalla, ZM; Gimi, B, 2007) |
| "LADG for early gastric cancer is a feasible and safe procedure with short-term clinical results superior to those of ODG." | 2.78 | Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial. ( Bax, L; Futawatari, N; Katada, N; Kikuchi, S; Okutomi, T; Sakuramoto, S; Wang, G; Watanabe, M; Yamashita, K, 2013) |
| "Indomethacin and NGX6 inhibit the proliferation and invasiveness of HT-29 and SW620 colon cancer cells by attenuating the WNT/ss-catenin signaling pathway." | 1.35 | Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway. ( Guo, Q; Lian, P; Liao, M; Shen, S; Wang, X; Wu, M; Xiao, Z, 2009) |
| "Two human pancreatic cancer cell lines were treated with CCK-8 alone, CCK-8 and staurosporine, or CCK-8 and indomethacine." | 1.30 | Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway. ( Fujimoto, Y; Hirata, M; Inoue, H; Iwao, T; Kajiyama, G; Kariya, K; Kawasaki, Y; Matsubara, K; Morinaka, K; Sasaki, T; Tsuchida, A; Yamamoto, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, CC | 1 |
| Suen, KM | 1 |
| Stainthorp, A | 1 |
| Wieteska, L | 1 |
| Biggs, GS | 1 |
| Leitão, A | 1 |
| Montanari, CA | 1 |
| Ladbury, JE | 1 |
| Mima, S | 1 |
| Takehara, M | 1 |
| Takada, H | 1 |
| Nishimura, T | 1 |
| Hoshino, T | 1 |
| Mizushima, T | 1 |
| Guo, Q | 1 |
| Wu, M | 1 |
| Lian, P | 1 |
| Liao, M | 1 |
| Xiao, Z | 1 |
| Wang, X | 1 |
| Shen, S | 1 |
| Sakuramoto, S | 1 |
| Yamashita, K | 1 |
| Kikuchi, S | 1 |
| Futawatari, N | 1 |
| Katada, N | 1 |
| Watanabe, M | 1 |
| Okutomi, T | 1 |
| Wang, G | 1 |
| Bax, L | 1 |
| Nithipatikom, K | 1 |
| Isbell, MA | 1 |
| Lindholm, PF | 1 |
| Kajdacsy-Balla, A | 1 |
| Kaul, S | 1 |
| Campell, WB | 1 |
| Peluffo, GD | 1 |
| Stillitani, I | 1 |
| Rodríguez, VA | 1 |
| Diament, MJ | 1 |
| Klein, SM | 1 |
| Wang, M | 1 |
| Yoshida, D | 1 |
| Liu, S | 1 |
| Teramoto, A | 1 |
| Moon, Y | 1 |
| Bottone, FG | 1 |
| McEntee, MF | 1 |
| Eling, TE | 1 |
| Ackerstaff, E | 1 |
| Gimi, B | 1 |
| Artemov, D | 2 |
| Bhujwalla, ZM | 2 |
| Pollard, M | 1 |
| Luckert, PH | 1 |
| Connolly, JM | 1 |
| Rose, DP | 1 |
| Young, MR | 1 |
| Lozano, Y | 1 |
| Djordjevic, A | 1 |
| Maier, GD | 1 |
| Young, ME | 1 |
| Hirata, M | 1 |
| Tsuchida, A | 1 |
| Iwao, T | 1 |
| Sasaki, T | 1 |
| Matsubara, K | 1 |
| Yamamoto, S | 1 |
| Morinaka, K | 1 |
| Kawasaki, Y | 1 |
| Fujimoto, Y | 1 |
| Inoue, H | 1 |
| Kariya, K | 1 |
| Kajiyama, G | 1 |
| Natarajan, K | 1 |
| Mori, N | 1 |
| Aboagye, EO | 1 |
| Chacko, VP | 1 |
| Mukai, M | 1 |
| Shinkai, K | 1 |
| Tateishi, R | 1 |
| Mori, Y | 1 |
| Akedo, H | 1 |
1 trial available for indomethacin and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial.
Topics: Administration, Rectal; Aged; Analgesia, Patient-Controlled; Analgesics; Carcinoma; Comorbidity; Cri | 2013 |
14 other studies available for indomethacin and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Movement; Drug Repositioning; E | 2019 |
NSAIDs suppress the expression of claudin-2 to promote invasion activity of cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Calcium; Cell Line, Tumor; Cell Mo | 2008 |
Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; beta Catenin; Cell Adhesion; Cell Communication; | 2009 |
Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion.
Topics: 6-Ketoprostaglandin F1 alpha; Adenocarcinoma; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2; | 2002 |
Reduction of tumor progression and paraneoplastic syndrome development in murine lung adenocarcinoma by nonsteroidal antiinflammatory drugs.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cell Survival; Chem | 2004 |
Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Brain Neoplasms; Cell Line, Tumor; Cell M | 2005 |
Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Colorectal Neopl | 2005 |
Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Tumor; Cytokines; Female; Gene | 2007 |
Prolonged antitumor effect of indomethacin on autochthonous intestinal tumors in rats.
Topics: Animals; Azo Compounds; Dimethylhydrazines; Indomethacin; Intestinal Neoplasms; Male; Methylazoxymet | 1983 |
Effects of fatty acids on invasion through reconstituted basement membrane ('Matrigel') by a human breast cancer cell line.
Topics: Analysis of Variance; Basement Membrane; Breast Neoplasms; Collagen; Drug Combinations; Eicosanoids; | 1993 |
Tumor responsiveness to the metastasis-stimulatory effects of prostaglandin E2 is restricted by protein phosphatases.
Topics: Animals; Cell Movement; Dinoprostone; Indomethacin; Lung Neoplasms; Mice; Neoplasm Invasiveness; Neo | 1997 |
Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway.
Topics: Blotting, Western; Cholecystokinin; Collagenases; Cyclooxygenase Inhibitors; Dinoprostone; Dopamine | 1999 |
Phospholipid profiles of invasive human breast cancer cells are altered towards a less invasive phospholipid profile by the anti-inflammatory agent indomethacin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Transformed; Humans; Indometha | 2000 |
Macrophage potentiation of invasive capacity of rat ascites hepatoma cells.
Topics: Animals; Catalase; Cells, Cultured; Culture Media; Dinoprostone; Free Radicals; Indomethacin; Liver | 1987 |