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indomethacin and Invasiveness, Neoplasm

indomethacin has been researched along with Invasiveness, Neoplasm in 15 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
" Here, we have investigated the effects of the anti-inflammatory agent indomethacin on the invasion and metabolism of the human breast cancer cell line MDA-MB-435 in Dulbecco's Modified Eagles (DME)-based or Roswell Park Memorial Institute (RPMI)-based cell medium, using a magnetic resonance-compatible invasion assay."7.74Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line. ( Ackerstaff, E; Artemov, D; Bhujwalla, ZM; Gimi, B, 2007)
"Indomethacin and NGX6 inhibit the proliferation and invasiveness of HT-29 and SW620 colon cancer cells by attenuating the WNT/ss-catenin signaling pathway."5.35Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway. ( Guo, Q; Lian, P; Liao, M; Shen, S; Wang, X; Wu, M; Xiao, Z, 2009)
" Here, we have investigated the effects of the anti-inflammatory agent indomethacin on the invasion and metabolism of the human breast cancer cell line MDA-MB-435 in Dulbecco's Modified Eagles (DME)-based or Roswell Park Memorial Institute (RPMI)-based cell medium, using a magnetic resonance-compatible invasion assay."3.74Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line. ( Ackerstaff, E; Artemov, D; Bhujwalla, ZM; Gimi, B, 2007)
"LADG for early gastric cancer is a feasible and safe procedure with short-term clinical results superior to those of ODG."2.78Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial. ( Bax, L; Futawatari, N; Katada, N; Kikuchi, S; Okutomi, T; Sakuramoto, S; Wang, G; Watanabe, M; Yamashita, K, 2013)
"Indomethacin and NGX6 inhibit the proliferation and invasiveness of HT-29 and SW620 colon cancer cells by attenuating the WNT/ss-catenin signaling pathway."1.35Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway. ( Guo, Q; Lian, P; Liao, M; Shen, S; Wang, X; Wu, M; Xiao, Z, 2009)
"Two human pancreatic cancer cell lines were treated with CCK-8 alone, CCK-8 and staurosporine, or CCK-8 and indomethacine."1.30Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway. ( Fujimoto, Y; Hirata, M; Inoue, H; Iwao, T; Kajiyama, G; Kariya, K; Kawasaki, Y; Matsubara, K; Morinaka, K; Sasaki, T; Tsuchida, A; Yamamoto, S, 1999)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's3 (20.00)18.2507
2000's8 (53.33)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lin, CC1
Suen, KM1
Stainthorp, A1
Wieteska, L1
Biggs, GS1
Leitão, A1
Montanari, CA1
Ladbury, JE1
Mima, S1
Takehara, M1
Takada, H1
Nishimura, T1
Hoshino, T1
Mizushima, T1
Guo, Q1
Wu, M1
Lian, P1
Liao, M1
Xiao, Z1
Wang, X1
Shen, S1
Sakuramoto, S1
Yamashita, K1
Kikuchi, S1
Futawatari, N1
Katada, N1
Watanabe, M1
Okutomi, T1
Wang, G1
Bax, L1
Nithipatikom, K1
Isbell, MA1
Lindholm, PF1
Kajdacsy-Balla, A1
Kaul, S1
Campell, WB1
Peluffo, GD1
Stillitani, I1
Rodríguez, VA1
Diament, MJ1
Klein, SM1
Wang, M1
Yoshida, D1
Liu, S1
Teramoto, A1
Moon, Y1
Bottone, FG1
McEntee, MF1
Eling, TE1
Ackerstaff, E1
Gimi, B1
Artemov, D2
Bhujwalla, ZM2
Pollard, M1
Luckert, PH1
Connolly, JM1
Rose, DP1
Young, MR1
Lozano, Y1
Djordjevic, A1
Maier, GD1
Young, ME1
Hirata, M1
Tsuchida, A1
Iwao, T1
Sasaki, T1
Matsubara, K1
Yamamoto, S1
Morinaka, K1
Kawasaki, Y1
Fujimoto, Y1
Inoue, H1
Kariya, K1
Kajiyama, G1
Natarajan, K1
Mori, N1
Aboagye, EO1
Chacko, VP1
Mukai, M1
Shinkai, K1
Tateishi, R1
Mori, Y1
Akedo, H1

Trials

1 trial available for indomethacin and Invasiveness, Neoplasm

ArticleYear
Laparoscopy versus open distal gastrectomy by expert surgeons for early gastric cancer in Japanese patients: short-term clinical outcomes of a randomized clinical trial.
    Surgical endoscopy, 2013, Volume: 27, Issue:5

    Topics: Administration, Rectal; Aged; Analgesia, Patient-Controlled; Analgesics; Carcinoma; Comorbidity; Cri

2013

Other Studies

14 other studies available for indomethacin and Invasiveness, Neoplasm

ArticleYear
Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.
    Cancer letters, 2019, 08-10, Volume: 457

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Movement; Drug Repositioning; E

2019
NSAIDs suppress the expression of claudin-2 to promote invasion activity of cancer cells.
    Carcinogenesis, 2008, Volume: 29, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Calcium; Cell Line, Tumor; Cell Mo

2008
Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway.
    Molecular and cellular biochemistry, 2009, Volume: 330, Issue:1-2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; beta Catenin; Cell Adhesion; Cell Communication;

2009
Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion.
    Clinical & experimental metastasis, 2002, Volume: 19, Issue:7

    Topics: 6-Ketoprostaglandin F1 alpha; Adenocarcinoma; Arachidonic Acid; Cyclooxygenase 1; Cyclooxygenase 2;

2002
Reduction of tumor progression and paraneoplastic syndrome development in murine lung adenocarcinoma by nonsteroidal antiinflammatory drugs.
    International journal of cancer, 2004, Jul-20, Volume: 110, Issue:6

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cell Survival; Chem

2004
Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study.
    Journal of neuro-oncology, 2005, Volume: 72, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Brain Neoplasms; Cell Line, Tumor; Cell M

2005
Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:10

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Colorectal Neopl

2005
Anti-inflammatory agent indomethacin reduces invasion and alters metabolism in a human breast cancer cell line.
    Neoplasia (New York, N.Y.), 2007, Volume: 9, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Tumor; Cytokines; Female; Gene

2007
Prolonged antitumor effect of indomethacin on autochthonous intestinal tumors in rats.
    Journal of the National Cancer Institute, 1983, Volume: 70, Issue:6

    Topics: Animals; Azo Compounds; Dimethylhydrazines; Indomethacin; Intestinal Neoplasms; Male; Methylazoxymet

1983
Effects of fatty acids on invasion through reconstituted basement membrane ('Matrigel') by a human breast cancer cell line.
    Cancer letters, 1993, Dec-10, Volume: 75, Issue:2

    Topics: Analysis of Variance; Basement Membrane; Breast Neoplasms; Collagen; Drug Combinations; Eicosanoids;

1993
Tumor responsiveness to the metastasis-stimulatory effects of prostaglandin E2 is restricted by protein phosphatases.
    Advances in experimental medicine and biology, 1997, Volume: 400A

    Topics: Animals; Cell Movement; Dinoprostone; Indomethacin; Lung Neoplasms; Mice; Neoplasm Invasiveness; Neo

1997
Cholecystokinin regulates the invasiveness of human pancreatic cancer cell lines via protein kinase C pathway.
    International journal of oncology, 1999, Volume: 14, Issue:6

    Topics: Blotting, Western; Cholecystokinin; Collagenases; Cyclooxygenase Inhibitors; Dinoprostone; Dopamine

1999
Phospholipid profiles of invasive human breast cancer cells are altered towards a less invasive phospholipid profile by the anti-inflammatory agent indomethacin.
    Advances in enzyme regulation, 2000, Volume: 40

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Transformed; Humans; Indometha

2000
Macrophage potentiation of invasive capacity of rat ascites hepatoma cells.
    Cancer research, 1987, Apr-15, Volume: 47, Issue:8

    Topics: Animals; Catalase; Cells, Cultured; Culture Media; Dinoprostone; Free Radicals; Indomethacin; Liver

1987