indomethacin and Intracranial Hemorrhages
indomethacin has been researched along with Intracranial Hemorrhages in 23 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Intracranial Hemorrhages: Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"We evaluated the effects of a novel pharmacological brain cooling (PBC) method with indomethacin (IND), a nonselective cyclooxygenase inhibitor, without the use of cooling blankets in patients with hemorrhagic stroke." | 9.12 | Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects. ( Abe, T; Aruga, T; Dohi, K; Fujita, S; Ikeda, Y; Jimbo, H; Ohtaki, H; Shioda, S, 2006) |
"The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia." | 8.91 | Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015) |
"We evaluated the effects of a novel pharmacological brain cooling (PBC) method with indomethacin (IND), a nonselective cyclooxygenase inhibitor, without the use of cooling blankets in patients with hemorrhagic stroke." | 5.12 | Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects. ( Abe, T; Aruga, T; Dohi, K; Fujita, S; Ikeda, Y; Jimbo, H; Ohtaki, H; Shioda, S, 2006) |
"The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g)." | 5.09 | Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. ( Davis, P; Moddemann, D; Ohlsson, A; Roberts, RS; Saigal, S; Schmidt, B; Solimano, A; Vincer, M; Wright, LL, 2001) |
"The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia." | 4.91 | Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015) |
" Early indomethacin was associated with a lower risk of patent ductus arteriosus and bronchopulmonary dysplasia and a higher risk of spontaneous intestinal perforation." | 4.12 | Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants. ( Ambalavanan, N; Bell, EF; Carlo, WA; Chawla, S; Chowdhury, D; Das, A; Gantz, M; Harmon, HM; Laptook, AR; Natarajan, G; Shankaran, S; Tapia, JL, 2022) |
"In this retrospective study, we tested the following hypotheses: rates of severe intraventricular hemorrhage (SIVH) and early neonatal survival are similar among extremely low birth weight (ELBW) infants treated with combination prophylaxis of phenobarbital and indomethacin compared with phenobarbital alone or no prophylaxis; and rates of patent ductus arteriosus (PDA) and necrotizing enterocolitis (NEC) are similar among indomethacin-exposed and nonexposed ELBW infants." | 3.73 | Combining phenobarbital and indomethacin to improve early neonatal outcomes in the extremely low birth weight infant. ( Ekekezie, II; Mundy, DC; Okah, FA, 2005) |
"Each center approached implementation of the practices differently." | 1.32 | Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants. ( Boyle, D; Buchanan, DS; Carteaux, P; Check, J; Clark, SE; Cohen, H; George, JA; Klein, SA; McKinley, P; McLendon, D; Michael, L; Moehring, J; Okuno-Jones, S; Secrest, JW; Whitfield, JM, 2003) |
"Frequency of side effects and recurrent patent ductus arteriosus did not differ between treatment groups." | 1.32 | Prophylactic indomethacin reduces grades III and IV intraventricular hemorrhages when compared to early indomethacin treatment of a patent ductus arteriosus. ( Baker, RW; Sobchak Brozanski, B; Yanowitz, TD, 2003) |
Research
Studies (23)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 12 (52.17) | 29.6817 |
2010's | 10 (43.48) | 24.3611 |
2020's | 1 (4.35) | 2.80 |
Authors
Authors | Studies |
---|---|
Chawla, S | 1 |
Natarajan, G | 1 |
Laptook, AR | 1 |
Chowdhury, D | 1 |
Bell, EF | 2 |
Ambalavanan, N | 1 |
Carlo, WA | 1 |
Gantz, M | 1 |
Das, A | 2 |
Tapia, JL | 1 |
Harmon, HM | 1 |
Shankaran, S | 2 |
Chiba, H | 1 |
Masutani, S | 1 |
Toyoshima, K | 1 |
Mori, R | 1 |
Hammers, AL | 2 |
Sanchez-Ramos, L | 2 |
Kaunitz, AM | 2 |
Malhotra, Y | 1 |
Nzegwu, N | 1 |
Harrington, J | 1 |
Ehrenkranz, RA | 1 |
Hafler, JP | 1 |
Hallman, M | 1 |
Pesonen, E | 1 |
Teramo, K | 1 |
Luu, TM | 1 |
Ment, LR | 1 |
Schneider, KC | 1 |
Katz, KH | 1 |
Allan, WC | 1 |
Vohr, BR | 2 |
Alfaleh, KM | 1 |
Al Luwaimi, E | 1 |
Alkharfi, TM | 1 |
Al-Alaiyan, SA | 1 |
Fanos, V | 1 |
Pusceddu, M | 1 |
Dessì, A | 1 |
Marcialis, MA | 1 |
Garner, RS | 1 |
Miller, C | 1 |
Burchfield, DJ | 1 |
Wadhawan, R | 1 |
Oh, W | 1 |
Saha, S | 1 |
Laptook, A | 1 |
Stoll, BJ | 1 |
Walsh, MC | 1 |
Higgins, R | 1 |
Heo, MJ | 1 |
Lee, OS | 1 |
Lim, SC | 1 |
McLendon, D | 1 |
Check, J | 1 |
Carteaux, P | 1 |
Michael, L | 1 |
Moehring, J | 1 |
Secrest, JW | 1 |
Clark, SE | 1 |
Cohen, H | 1 |
Klein, SA | 1 |
Boyle, D | 1 |
George, JA | 1 |
Okuno-Jones, S | 1 |
Buchanan, DS | 1 |
McKinley, P | 1 |
Whitfield, JM | 1 |
Yanowitz, TD | 1 |
Baker, RW | 1 |
Sobchak Brozanski, B | 1 |
Kumar Nair, PA | 1 |
Pai, MG | 1 |
Gazal, HA | 1 |
Da Costa, DE | 1 |
Al Khusaiby, SM | 1 |
Dutta, S | 1 |
Okah, FA | 1 |
Mundy, DC | 1 |
Ekekezie, II | 1 |
Doyle, NM | 1 |
Gardner, MO | 1 |
Wells, L | 1 |
Qualls, C | 1 |
Papile, LA | 1 |
Ohlsson, A | 2 |
Roberts, RS | 2 |
Schmidt, B | 2 |
Davis, P | 2 |
Moddeman, D | 1 |
Saigal, S | 2 |
Solimano, A | 2 |
Vincer, M | 2 |
Wright, L | 1 |
Dohi, K | 1 |
Jimbo, H | 1 |
Ikeda, Y | 1 |
Fujita, S | 1 |
Ohtaki, H | 1 |
Shioda, S | 1 |
Abe, T | 1 |
Aruga, T | 1 |
Suarez, RD | 1 |
Grobman, WA | 1 |
Parilla, BV | 1 |
Weintraub, Z | 1 |
Solovechick, M | 1 |
Reichman, B | 1 |
Rotschild, A | 1 |
Waisman, D | 1 |
Davkin, O | 1 |
Lusky, A | 1 |
Bental, Y | 1 |
Moddemann, D | 1 |
Wright, LL | 1 |
Clinical Trials (4)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants[NCT00063063] | 80,000 participants (Anticipated) | Observational | 1987-01-31 | Recruiting | |||
Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)[NCT00009646] | Phase 3 | 1,202 participants (Actual) | Interventional | 1993-11-30 | Completed | ||
High-Dose Erythropoietin in Very Low Birth Weight Infants for the Potential Treatment of Prematurity-Related Cerebral Hemorrhagic-Ischemic Injury: A Phase II Safety/Tolerability Study[NCT00589953] | Phase 2 | 22 participants (Actual) | Interventional | 2007-07-31 | Terminated | ||
Follow-up Visit of High Risk Infants[NCT00009633] | 68,000 participants (Anticipated) | Observational | 1993-01-31 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
3 reviews available for indomethacin and Intracranial Hemorrhages
Article | Year |
---|---|
Indomethacin for preterm infants with intracranial hemorrhage.
Topics: Cardiovascular Agents; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Infant, Pre | 2013 |
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis.
Topics: Cerebral Ventricles; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infa | 2015 |
Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Extre | 2011 |
Trials
4 trials available for indomethacin and Intracranial Hemorrhages
Article | Year |
---|---|
Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age.
Topics: Brain Damage, Chronic; Cerebral Ventricles; Child; Child Behavior Disorders; Child, Preschool; Cogni | 2009 |
Indomethacin prophylaxis for intraventricular hemorrhage in very low birth weight babies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arabs; Asian People; Humans; Indomethacin; Infant, Newborn; | 2004 |
Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects.
Topics: Acute Disease; Aged; Body Temperature; Brain; Cryotherapy; Cyclooxygenase Inhibitors; Cytokines; Fem | 2006 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin | 2001 |
Other Studies
16 other studies available for indomethacin and Intracranial Hemorrhages
Article | Year |
---|---|
Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants.
Topics: Bronchopulmonary Dysplasia; Child; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant; | 2022 |
Identifying Barriers to Initiating Minimal Enteral Feedings in Very Low-Birth-Weight Infants: A Mixed Methods Approach.
Topics: Enteral Nutrition; Health Personnel; Humans; Indomethacin; Infant; Infant, Extremely Premature; Infa | 2016 |
Reply: To PMID 25448524.
Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe | 2015 |
Indomethacin as a tocolytic harmful to preterm infant.
Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe | 2015 |
A decision aid for considering indomethacin prophylaxis vs. symptomatic treatment of PDA for extreme low birth weight infants.
Topics: Adult; Bronchopulmonary Dysplasia; Cardiovascular Agents; Decision Support Techniques; Ductus Arteri | 2011 |
Prophylactic indomethacin infusion increases fractional cerebral oxygen extraction in ELBW neonates.
Topics: Brain; Carbon Dioxide; Cerebral Ventricles; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; | 2012 |
Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Developmental Disabilities; Ductus Arteriosus, Paten | 2013 |
Comparative evaluation for the use of oral ibuprofen and intravenous indomethacin in Korean infants with patent ductus.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Comorbidity; Ductus Arteriosus, Paten | 2012 |
Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benchmarking; Body Temperature; Brain Ischemia; Cooperative | 2003 |
Prophylactic indomethacin reduces grades III and IV intraventricular hemorrhages when compared to early indomethacin treatment of a patent ductus arteriosus.
Topics: Cardiovascular Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Ductus Arteri | 2003 |
Indomethacin prophylaxis for intraventricular hemorrhage in very low birth weight babies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemoprevention; Humans; Indomethacin; Infant, Newborn; Inf | 2004 |
Combining phenobarbital and indomethacin to improve early neonatal outcomes in the extremely low birth weight infant.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Therapy, Combination; Enterocolitis, | 2005 |
Outcome of very low birth weight infants exposed to antenatal indomethacin for tocolysis.
Topics: Cause of Death; Cohort Studies; Critical Care; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing | 2005 |
Male/female differences in indomethacin effects in preterm infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebral Ventricles; Developmental Disabilities; Female; Hu | 2005 |
Indomethacin tocolysis and intraventricular hemorrhage.
Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Confiden | 2001 |
Effect of maternal tocolysis on the incidence of severe periventricular/intraventricular haemorrhage in very low birthweight infants.
Topics: Anti-Inflammatory Agents; Apgar Score; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; I | 2001 |