Page last updated: 2024-10-29

indomethacin and Intracranial Hemorrhages

indomethacin has been researched along with Intracranial Hemorrhages in 23 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Intracranial Hemorrhages: Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.

Research Excerpts

ExcerptRelevanceReference
"We evaluated the effects of a novel pharmacological brain cooling (PBC) method with indomethacin (IND), a nonselective cyclooxygenase inhibitor, without the use of cooling blankets in patients with hemorrhagic stroke."9.12Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects. ( Abe, T; Aruga, T; Dohi, K; Fujita, S; Ikeda, Y; Jimbo, H; Ohtaki, H; Shioda, S, 2006)
"The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia."8.91Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015)
"We evaluated the effects of a novel pharmacological brain cooling (PBC) method with indomethacin (IND), a nonselective cyclooxygenase inhibitor, without the use of cooling blankets in patients with hemorrhagic stroke."5.12Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects. ( Abe, T; Aruga, T; Dohi, K; Fujita, S; Ikeda, Y; Jimbo, H; Ohtaki, H; Shioda, S, 2006)
"The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g)."5.09Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. ( Davis, P; Moddemann, D; Ohlsson, A; Roberts, RS; Saigal, S; Schmidt, B; Solimano, A; Vincer, M; Wright, LL, 2001)
"The use of indomethacin as a tocolytic agent for preterm labor is associated with an increased risk for severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia."4.91Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( Hammers, AL; Kaunitz, AM; Sanchez-Ramos, L, 2015)
" Early indomethacin was associated with a lower risk of patent ductus arteriosus and bronchopulmonary dysplasia and a higher risk of spontaneous intestinal perforation."4.12Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants. ( Ambalavanan, N; Bell, EF; Carlo, WA; Chawla, S; Chowdhury, D; Das, A; Gantz, M; Harmon, HM; Laptook, AR; Natarajan, G; Shankaran, S; Tapia, JL, 2022)
"In this retrospective study, we tested the following hypotheses: rates of severe intraventricular hemorrhage (SIVH) and early neonatal survival are similar among extremely low birth weight (ELBW) infants treated with combination prophylaxis of phenobarbital and indomethacin compared with phenobarbital alone or no prophylaxis; and rates of patent ductus arteriosus (PDA) and necrotizing enterocolitis (NEC) are similar among indomethacin-exposed and nonexposed ELBW infants."3.73Combining phenobarbital and indomethacin to improve early neonatal outcomes in the extremely low birth weight infant. ( Ekekezie, II; Mundy, DC; Okah, FA, 2005)
"Each center approached implementation of the practices differently."1.32Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants. ( Boyle, D; Buchanan, DS; Carteaux, P; Check, J; Clark, SE; Cohen, H; George, JA; Klein, SA; McKinley, P; McLendon, D; Michael, L; Moehring, J; Okuno-Jones, S; Secrest, JW; Whitfield, JM, 2003)
"Frequency of side effects and recurrent patent ductus arteriosus did not differ between treatment groups."1.32Prophylactic indomethacin reduces grades III and IV intraventricular hemorrhages when compared to early indomethacin treatment of a patent ductus arteriosus. ( Baker, RW; Sobchak Brozanski, B; Yanowitz, TD, 2003)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (52.17)29.6817
2010's10 (43.48)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Chawla, S1
Natarajan, G1
Laptook, AR1
Chowdhury, D1
Bell, EF2
Ambalavanan, N1
Carlo, WA1
Gantz, M1
Das, A2
Tapia, JL1
Harmon, HM1
Shankaran, S2
Chiba, H1
Masutani, S1
Toyoshima, K1
Mori, R1
Hammers, AL2
Sanchez-Ramos, L2
Kaunitz, AM2
Malhotra, Y1
Nzegwu, N1
Harrington, J1
Ehrenkranz, RA1
Hafler, JP1
Hallman, M1
Pesonen, E1
Teramo, K1
Luu, TM1
Ment, LR1
Schneider, KC1
Katz, KH1
Allan, WC1
Vohr, BR2
Alfaleh, KM1
Al Luwaimi, E1
Alkharfi, TM1
Al-Alaiyan, SA1
Fanos, V1
Pusceddu, M1
Dessì, A1
Marcialis, MA1
Garner, RS1
Miller, C1
Burchfield, DJ1
Wadhawan, R1
Oh, W1
Saha, S1
Laptook, A1
Stoll, BJ1
Walsh, MC1
Higgins, R1
Heo, MJ1
Lee, OS1
Lim, SC1
McLendon, D1
Check, J1
Carteaux, P1
Michael, L1
Moehring, J1
Secrest, JW1
Clark, SE1
Cohen, H1
Klein, SA1
Boyle, D1
George, JA1
Okuno-Jones, S1
Buchanan, DS1
McKinley, P1
Whitfield, JM1
Yanowitz, TD1
Baker, RW1
Sobchak Brozanski, B1
Kumar Nair, PA1
Pai, MG1
Gazal, HA1
Da Costa, DE1
Al Khusaiby, SM1
Dutta, S1
Okah, FA1
Mundy, DC1
Ekekezie, II1
Doyle, NM1
Gardner, MO1
Wells, L1
Qualls, C1
Papile, LA1
Ohlsson, A2
Roberts, RS2
Schmidt, B2
Davis, P2
Moddeman, D1
Saigal, S2
Solimano, A2
Vincer, M2
Wright, L1
Dohi, K1
Jimbo, H1
Ikeda, Y1
Fujita, S1
Ohtaki, H1
Shioda, S1
Abe, T1
Aruga, T1
Suarez, RD1
Grobman, WA1
Parilla, BV1
Weintraub, Z1
Solovechick, M1
Reichman, B1
Rotschild, A1
Waisman, D1
Davkin, O1
Lusky, A1
Bental, Y1
Moddemann, D1
Wright, LL1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants[NCT00063063]80,000 participants (Anticipated)Observational1987-01-31Recruiting
Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)[NCT00009646]Phase 31,202 participants (Actual)Interventional1993-11-30Completed
High-Dose Erythropoietin in Very Low Birth Weight Infants for the Potential Treatment of Prematurity-Related Cerebral Hemorrhagic-Ischemic Injury: A Phase II Safety/Tolerability Study[NCT00589953]Phase 222 participants (Actual)Interventional2007-07-31Terminated
Follow-up Visit of High Risk Infants[NCT00009633]68,000 participants (Anticipated)Observational1993-01-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for indomethacin and Intracranial Hemorrhages

ArticleYear
Indomethacin for preterm infants with intracranial hemorrhage.
    Pediatrics international : official journal of the Japan Pediatric Society, 2013, Volume: 55, Issue:1

    Topics: Cardiovascular Agents; Ductus Arteriosus, Patent; Humans; Indomethacin; Infant, Newborn; Infant, Pre

2013
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis.
    American journal of obstetrics and gynecology, 2015, Volume: 212, Issue:4

    Topics: Cerebral Ventricles; Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Infant, Newborn; Infa

2015
Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?
    Clinics (Sao Paulo, Brazil), 2011, Volume: 66, Issue:12

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Extre

2011

Trials

4 trials available for indomethacin and Intracranial Hemorrhages

ArticleYear
Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age.
    Pediatrics, 2009, Volume: 123, Issue:3

    Topics: Brain Damage, Chronic; Cerebral Ventricles; Child; Child Behavior Disorders; Child, Preschool; Cogni

2009
Indomethacin prophylaxis for intraventricular hemorrhage in very low birth weight babies.
    Indian pediatrics, 2004, Volume: 41, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arabs; Asian People; Humans; Indomethacin; Infant, Newborn;

2004
Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects.
    Acta neurochirurgica. Supplement, 2006, Volume: 96

    Topics: Acute Disease; Aged; Body Temperature; Brain; Cryotherapy; Cyclooxygenase Inhibitors; Cytokines; Fem

2006
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
    The New England journal of medicine, 2001, Jun-28, Volume: 344, Issue:26

    Topics: Blindness; Cerebral Palsy; Cognition Disorders; Ductus Arteriosus, Patent; Enterocolitis, Necrotizin

2001

Other Studies

16 other studies available for indomethacin and Intracranial Hemorrhages

ArticleYear
Model for severe intracranial hemorrhage and role of early indomethacin in extreme preterm infants.
    Pediatric research, 2022, Volume: 92, Issue:6

    Topics: Bronchopulmonary Dysplasia; Child; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant;

2022
Identifying Barriers to Initiating Minimal Enteral Feedings in Very Low-Birth-Weight Infants: A Mixed Methods Approach.
    American journal of perinatology, 2016, Volume: 33, Issue:1

    Topics: Enteral Nutrition; Health Personnel; Humans; Indomethacin; Infant; Infant, Extremely Premature; Infa

2016
Reply: To PMID 25448524.
    American journal of obstetrics and gynecology, 2015, Volume: 213, Issue:6

    Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe

2015
Indomethacin as a tocolytic harmful to preterm infant.
    American journal of obstetrics and gynecology, 2015, Volume: 213, Issue:6

    Topics: Enterocolitis, Necrotizing; Female; Humans; Indomethacin; Intracranial Hemorrhages; Leukomalacia, Pe

2015
A decision aid for considering indomethacin prophylaxis vs. symptomatic treatment of PDA for extreme low birth weight infants.
    BMC pediatrics, 2011, Sep-03, Volume: 11

    Topics: Adult; Bronchopulmonary Dysplasia; Cardiovascular Agents; Decision Support Techniques; Ductus Arteri

2011
Prophylactic indomethacin infusion increases fractional cerebral oxygen extraction in ELBW neonates.
    Journal of perinatology : official journal of the California Perinatal Association, 2012, Volume: 32, Issue:9

    Topics: Brain; Carbon Dioxide; Cerebral Ventricles; Cerebrovascular Circulation; Cyclooxygenase Inhibitors;

2012
Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Developmental Disabilities; Ductus Arteriosus, Paten

2013
Comparative evaluation for the use of oral ibuprofen and intravenous indomethacin in Korean infants with patent ductus.
    Archives of pharmacal research, 2012, Volume: 35, Issue:9

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Comorbidity; Ductus Arteriosus, Paten

2012
Implementation of potentially better practices for the prevention of brain hemorrhage and ischemic brain injury in very low birth weight infants.
    Pediatrics, 2003, Volume: 111, Issue:4 Pt 2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benchmarking; Body Temperature; Brain Ischemia; Cooperative

2003
Prophylactic indomethacin reduces grades III and IV intraventricular hemorrhages when compared to early indomethacin treatment of a patent ductus arteriosus.
    Journal of perinatology : official journal of the California Perinatal Association, 2003, Volume: 23, Issue:4

    Topics: Cardiovascular Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Ductus Arteri

2003
Indomethacin prophylaxis for intraventricular hemorrhage in very low birth weight babies.
    Indian pediatrics, 2004, Volume: 41, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemoprevention; Humans; Indomethacin; Infant, Newborn; Inf

2004
Combining phenobarbital and indomethacin to improve early neonatal outcomes in the extremely low birth weight infant.
    American journal of perinatology, 2005, Volume: 22, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Therapy, Combination; Enterocolitis,

2005
Outcome of very low birth weight infants exposed to antenatal indomethacin for tocolysis.
    Journal of perinatology : official journal of the California Perinatal Association, 2005, Volume: 25, Issue:5

    Topics: Cause of Death; Cohort Studies; Critical Care; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing

2005
Male/female differences in indomethacin effects in preterm infants.
    The Journal of pediatrics, 2005, Volume: 147, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebral Ventricles; Developmental Disabilities; Female; Hu

2005
Indomethacin tocolysis and intraventricular hemorrhage.
    Obstetrics and gynecology, 2001, Volume: 97, Issue:6

    Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Confiden

2001
Effect of maternal tocolysis on the incidence of severe periventricular/intraventricular haemorrhage in very low birthweight infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2001, Volume: 85, Issue:1

    Topics: Anti-Inflammatory Agents; Apgar Score; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; I

2001
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