indomethacin has been researched along with Intestinal Obstruction in 16 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Intestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 5.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| "A patient on long-term indomethacin therapy developed intestinal obstruction due to ileal strictures." | 3.67 | Ileal stricturing after long-term indomethacin treatment. ( Grundy, A; Maxwell, JD; Saverymuttu, SH; Thomas, A, 1986) |
| "Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy." | 1.27 | Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin. ( Isaacs, P; Keshavarzian, A; McColl, I; Sladen, GE, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shafiq, N | 1 |
| Malhotra, S | 1 |
| Pandhi, P | 1 |
| Keshavarzian, A | 1 |
| Isaacs, P | 1 |
| McColl, I | 1 |
| Sladen, GE | 1 |
| Zalev, AH | 1 |
| Gardiner, GW | 1 |
| Scholz, FJ | 1 |
| Heiss, FW | 1 |
| Roberts, PL | 1 |
| Thomas, C | 1 |
| Pucius, RJ | 1 |
| Charles, AK | 1 |
| Adair, HM | 1 |
| Rowe, RC | 1 |
| Hacking, JC | 1 |
| Hooker, GD | 1 |
| Gregor, JC | 1 |
| Ponich, TP | 1 |
| McLarty, TD | 1 |
| De Winter, BY | 1 |
| Boeckxstaens, GE | 1 |
| De Man, JG | 1 |
| Moreels, TG | 1 |
| Herman, AG | 1 |
| Pelckmans, PA | 1 |
| O'Bichere, A | 1 |
| Campbell, DJ | 1 |
| Schwarz, NT | 1 |
| Kalff, JC | 1 |
| Türler, A | 1 |
| Engel, BM | 1 |
| Watkins, SC | 1 |
| Billiar, TR | 1 |
| Bauer, AJ | 1 |
| MacGregor, IL | 1 |
| Lavigne, ME | 1 |
| Luderer, JR | 1 |
| Demers, LM | 1 |
| Bonnem, EM | 1 |
| Saleem, A | 1 |
| Jeffries, GH | 1 |
| Hajjar, JJ | 1 |
| Van Linda, B | 1 |
| Fucci, J | 1 |
| Tomicic, T | 1 |
| Goldman, CD | 1 |
| Rudloff, MA | 1 |
| Ternberg, JL | 1 |
| Saverymuttu, SH | 1 |
| Thomas, A | 1 |
| Grundy, A | 1 |
| Maxwell, JD | 1 |
| Sturges, HF | 1 |
| Krone, CL | 1 |
| Summers, RW | 1 |
| Kent, TH | 1 |
| Osborne, JW | 1 |
16 other studies available for indomethacin and Intestinal Obstruction
| Article | Year |
|---|---|
Effect of cyclooxygenase inhibitors in postoperative ileus: an experimental study.
Topics: Animals; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Female; Indomethaci | 2002 |
Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin.
Topics: Adult; Body Weight; Constipation; Humans; Ileostomy; Indomethacin; Intestinal Obstruction; Intestina | 1983 |
Drug-induced diaphragmlike small-bowel strictures.
Topics: Female; Humans; Indomethacin; Intestinal Obstruction; Jejunal Diseases; Middle Aged; Radiography | 1994 |
Diaphragmlike strictures of the small bowel associated with use of nonsteroidal antiinflammatory drugs.
Topics: Aged; Humans; Indomethacin; Intestinal Obstruction; Intestine, Small; Male; Radiography | 1994 |
Diaphragm-like strictures of the colon induced by non-steroidal anti-inflammatory drugs.
Topics: Colonic Diseases; Female; Humans; Ileal Diseases; Indomethacin; Intestinal Obstruction; Middle Aged | 1993 |
Diaphragm-like strictures of the right colon induced by indomethacin suppositories: evidence of a systemic effect.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colectomy; Colonic Diseases; Colonoscopy; Female; F | 1996 |
Differential effect of indomethacin and ketorolac on postoperative ileus in rats.
Topics: Animals; Disease Models, Animal; Indomethacin; Intestinal Obstruction; Ketorolac; Nitric Oxide; Nitr | 1998 |
Gastrointestinal: diaphragm disease.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Psoriatic; Humans; Ileal Diseases | 1999 |
Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Digestive System | 2001 |
Inhibition by indomethocin of intestinal distension induced secretion in the rat.
Topics: Animals; Catheterization; Ileum; Indomethacin; Intestinal Obstruction; Intestinal Secretions; Male; | 1979 |
Elevated prostaglandin e in idiopathic intestinal pseudo-obstruction.
Topics: Adult; Diagnosis, Differential; Female; Humans; Indomethacin; Intestinal Obstruction; Platelet Aggre | 1976 |
Intestinal absorption in the mechanically obstructed rat intestine: protection by prostaglandins.
Topics: 16,16-Dimethylprostaglandin E2; Alanine; Animals; Arachidonic Acid; Arachidonic Acids; Clindamycin; | 1986 |
Cytoprotective agents in experimental small bowel volvulus.
Topics: Alprostadil; Animals; Aspirin; Ephedrine; Ibuprofen; Indomethacin; Intestinal Obstruction; Intestine | 1987 |
Ileal stricturing after long-term indomethacin treatment.
Topics: Arthritis, Rheumatoid; Constriction, Pathologic; Female; Humans; Ileal Diseases; Indomethacin; Intes | 1986 |
Ulceration and stricture of the jejunum in a patient on long-term indomethacin therapy.
Topics: Humans; Indomethacin; Intestinal Obstruction; Jejunum; Male; Middle Aged; Radiography; Spondylitis, | 1973 |
Effects of drugs, ileal obstruction, and irradiation on rat gastrointestinal propulsion.
Topics: Animals; Chlorisondamine; Chlorpromazine; Chromium Isotopes; Fasting; Gastrointestinal Motility; Ile | 1970 |