indomethacin has been researched along with Intestinal Diseases in 124 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Intestinal Diseases: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of lansoprazole, a proton pump inhibitor (PPI), on indomethacin-induced small intestinal ulceration was examined in rats, particularly in relation to heme oxygenase (HO)-1." | 7.76 | Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1. ( Amagase, K; Higuchi, K; Kakimoto, K; Kato, S; Murano, M; Nishio, H; Takeuchi, K; Tokioka, S; Umegaki, E; Yoda, Y, 2010) |
| "We examined the effect of tacrolimus (FK506), an immunosuppressive drug, on indomethacin-induced small intestinal ulceration in rats." | 7.74 | Tacrolimus (FK506), an immunosuppressive agent, prevents indomethacin-induced small intestinal ulceration in the rat: inhibition of inducible nitric oxide synthase expression. ( Kato, S; Nishio, H; Ogura, M; Takeuchi, K, 2007) |
| "After indomethacin treatment small-intestinal ulcers were less severe in the LS than in the SC group (ulcer index: median, 0." | 7.70 | Protective effect of lactosucrose on intracolonic indomethacin-induced small-intestinal ulcers in rats. ( Honda, K; Iida, M; Kuroki, F; Matsumoto, T; Oka, M; Sawatani, I, 1999) |
| " We studied the effect of the oxygen radical scavengers superoxide dismutase (SOD), catalase (CAT), and allopurinol (ALLO) on indomethacin (INDO)-induced intestinal ulceration in the rat." | 7.69 | Oxygen radical scavengers are protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Fisher, S; Heckelman, B; Kiro, A; Marcus, H; Zahavi, I, 1995) |
| "Participation of microcirculatory disturbances, especially the role of 5-lipoxygenase products from neutrophils, was investigated in indomethacin (Indo)-induced ulcers of rat small intestine." | 7.68 | Microcirculatory disturbance in indomethacin-induced intestinal ulcer. ( Houzawa, S; Kurose, I; Miura, S; Nagata, H; Serizawa, H; Suematsu, M; Suzuki, M; Tanaka, S; Tsuchiya, M, 1991) |
| " We studied the effect of L-dopa and related substances on indomethacin-induced intestinal ulceration in the rat." | 7.68 | L-dopa is protective against indomethacin-induced small intestinal ulceration in the rat: possible role of an alpha-2-adrenergic mechanism. ( Dinari, G; Kiro, A; Marcus, H; Zahavi, I, 1992) |
| "Encapsulation of indomethacin into egg phosphatidylcholine (EPC) monophasic vesicles (MPV) or into stable plurilamellar vesicles (SPLV) before oral administration to rats substantially reduced or eliminated the gastric and intestinal ulceration normally associated with ingestion of this drug." | 7.67 | Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats. ( Fielder, FG; Ginsberg, RS; Godin-Ostro, E; Slusher, MA; Soehngen, EC; Weiner, AL, 1988) |
| "Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats." | 7.67 | Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985) |
| "Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats." | 7.67 | Naloxone is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Ligumsky, M; Marcus, H; Nitzan, M; Rosenbach, Y; Waisman, Y; Zahavi, I, 1985) |
| "The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers." | 7.67 | The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats. ( Beró, T; Jávor, T; Mózsik, G; Németh, A, 1984) |
| "It has been developed a new simple method for the evaluation of intestinal ulceration induced by indomethacin or other drug in rats." | 7.67 | Quantitative analysis of intestinal ulceration induced by indomethacin, in rats. ( Ezer, E, 1987) |
| "Capsaicin desensitization increases degree and incidence of indomethacin-induced intestinal ulcers in rats, suggesting the existence of a capsaicin-sensitive mechanism(s) in the protection of the intestinal mucosa against indomethacin-induced ulceration." | 7.67 | Involvement of capsaicin-sensitive mechanism(s) in the antiulcer defence of intestinal mucosa in rats. ( Evangelista, S; Maggi, CA; Meli, A, 1987) |
| " FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug." | 7.67 | Further studies on the mechanism of fat-free diet (FFD)--protection against indomethacin-induced intestinal ulcers in the rat. ( Barzanti, A; Ciappi, R; Evangelista, S; Meli, A; Ortolani, C, 1985) |
| "Lafutidine (LAF) is a novel histamine H2 receptor antagonist with a mucosal protective action." | 5.91 | Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota. ( Chen, J; Chen, X; Guo, J; Liang, H; Liu, Q; Lou, C; Luo, Y; Song, C; Sun, S; Wang, B; Xu, X; Zhao, J; Zhong, W; Zhu, L, 2023) |
| " Vancomycin (VCM), a poorly absorbed drug, was administered intraduodenally to rats with SIUs." | 5.40 | Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Inoue, J; Kawauchi, S; Miki, I; Mizuno, S; Nakamura, T; Nishikawa, C; Tanahashi, T; Yasui, H, 2014) |
| "Indomethacin treatment markedly enhanced inducible nitric oxide synthase and chemokine mRNA expression in the small intestine, but these responses were all significantly attenuated by either domperidone or metoclopramide." | 5.37 | Dopamine D₂-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating α7 nicotinic acetylcholine receptors. ( Amagase, K; Hashimura, H; Iimori, M; Kato, S; Kawahara, R; Takeuchi, K; Yamanaka, N; Yasuda, M, 2011) |
| "Indomethacin was administered subcutaneously to rats, 4 mg/kg/day for 4 consecutive days in order to produce erosions of the small intestine which were scored at necropsy on day 5." | 5.27 | Diphenyldisulfide inhibits indomethacin-induced ulcerogenesis in rats. ( Tomolonis, AJ; Young, JM, 1987) |
| "Indomethacin-treated suckling animals prevented from weaning did not develop intestinal lesions until they had access to solid food on day 23." | 5.27 | Indomethacin fails to induce ulceration in the gastrointestinal tract of newborn and suckling rats. ( Bedrick, AD; Holtzapple, PG, 1986) |
| "We examined changes in the expression of a pro-angiogenic factor, vascular endothelial growth factor (VEGF), and an anti-angiogenic factor, endostatin, as well as matrix metalloproteinase (MMP)-2 and MMP-9 in the rat small intestine after administration of indomethacin and investigated the roles of these factors in the healing of indomethacin-induced small intestinal ulcers." | 3.79 | Roles of pro-angiogenic and anti-angiogenic factors as well as matrix metalloproteinases in healing of NSAID-induced small intestinal ulcers in rats. ( Amagase, K; Gyenge, M; Kunimi, S; Matsuoka, R; Takeuchi, K, 2013) |
| "The effect of lansoprazole, a proton pump inhibitor (PPI), on indomethacin-induced small intestinal ulceration was examined in rats, particularly in relation to heme oxygenase (HO)-1." | 3.76 | Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1. ( Amagase, K; Higuchi, K; Kakimoto, K; Kato, S; Murano, M; Nishio, H; Takeuchi, K; Tokioka, S; Umegaki, E; Yoda, Y, 2010) |
| "The role of dietary fibre (DF), intestinal motility and leukotrienes (LTs) in the formation of small intestinal ulcers induced by indomethacin (IND) was investigated in cats." | 3.75 | Role of dietary fibres, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in cats. ( Hatao, K; Nishimura, S; Otsuka, N; Satoh, H; Shiotani, S, 2009) |
| "Intestinal ulcers were induced in rats by subcutaneous administration of indomethacin." | 3.75 | PET and macro- and microautoradiographic studies combined with immunohistochemistry for monitoring rat intestinal ulceration and healing processes. ( Kataoka, Y; Mizuma, H; Wada, Y; Watanabe, Y; Yamato, M, 2009) |
| "We examined the effect of tacrolimus (FK506), an immunosuppressive drug, on indomethacin-induced small intestinal ulceration in rats." | 3.74 | Tacrolimus (FK506), an immunosuppressive agent, prevents indomethacin-induced small intestinal ulceration in the rat: inhibition of inducible nitric oxide synthase expression. ( Kato, S; Nishio, H; Ogura, M; Takeuchi, K, 2007) |
| "The effect of irsogladine maleate, a widely used antiulcer drug in Japan, on indomethacin-induced small intestinal lesions was examined in rats." | 3.74 | Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats. ( Amagase, K; Hatazawa, R; Kamei, K; Kato, N; Kubo, Y; Takeuchi, K, 2008) |
| "The role of prostaglandins (PGs)/cyclooxygenase (COX) in the healing of indomethacin-induced small intestinal ulcers was examined in rats." | 3.73 | Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats. ( Hatazawa, R; Ohno, R; Takeuchi, K; Tanaka, A; Tanigami, M, 2006) |
| "Mother-reared and artificially fed infant rats demonstrated resistance to the ulcerogenic effects of indomethacin, in contrast to the adults." | 3.71 | Indomethacin, dexamethasone, and intestinal damage in infant rats. ( Clare-Salzler, M; DeMarco, VG; Li, YY; Neu, J; Patel, MR, 2002) |
| "After indomethacin treatment small-intestinal ulcers were less severe in the LS than in the SC group (ulcer index: median, 0." | 3.70 | Protective effect of lactosucrose on intracolonic indomethacin-induced small-intestinal ulcers in rats. ( Honda, K; Iida, M; Kuroki, F; Matsumoto, T; Oka, M; Sawatani, I, 1999) |
| " Inhibition of prostaglandin synthesis by traditional NSAIDs such as indomethacin and diclofenac which non-selectively inhibit both PGHS-1 and PGHS-2, causes gastric and intestinal ulceration and delays gastric ulcer healing in chronic models." | 3.70 | Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. ( Flogerzi, B; Halter, F; Netzer, P; Peskar, BM; Schmassmann, A; Stettler, C; Stroff, T, 1998) |
| " We studied the effect of the oxygen radical scavengers superoxide dismutase (SOD), catalase (CAT), and allopurinol (ALLO) on indomethacin (INDO)-induced intestinal ulceration in the rat." | 3.69 | Oxygen radical scavengers are protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Fisher, S; Heckelman, B; Kiro, A; Marcus, H; Zahavi, I, 1995) |
| "The effects of dietary pretreatment on longitudinal ulcers of the intestine induced by indomethacin given intracolonically were investigated in rats." | 3.69 | Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes. ( Fujishima, M; Hizawa, K; Iida, M; Koga, H; Kuroki, F; Matsumoto, T, 1994) |
| "Participation of microcirculatory disturbances, especially the role of 5-lipoxygenase products from neutrophils, was investigated in indomethacin (Indo)-induced ulcers of rat small intestine." | 3.68 | Microcirculatory disturbance in indomethacin-induced intestinal ulcer. ( Houzawa, S; Kurose, I; Miura, S; Nagata, H; Serizawa, H; Suematsu, M; Suzuki, M; Tanaka, S; Tsuchiya, M, 1991) |
| " We studied the effect of L-dopa and related substances on indomethacin-induced intestinal ulceration in the rat." | 3.68 | L-dopa is protective against indomethacin-induced small intestinal ulceration in the rat: possible role of an alpha-2-adrenergic mechanism. ( Dinari, G; Kiro, A; Marcus, H; Zahavi, I, 1992) |
| "The effect of various gastric cytoprotective drugs was studied on the development of indomethacin induced intestinal ulcers." | 3.67 | The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats. ( Beró, T; Jávor, T; Mózsik, G; Németh, A, 1984) |
| "1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido 1,2-a pyrimidine-3-carboxamide (Ch-127) significantly inhibited the intestinal ulceration induced by a single dose of indomethacin (15 mg/kg p." | 3.67 | 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido(1,2-a)- pyrimidine-3-carboxamide (Ch-127) protects against the intestinal damage in rats caused by two weeks' daily administration of indomethacin. ( Gyires, K; Hermecz, I; Knoll, J, 1987) |
| "It has been developed a new simple method for the evaluation of intestinal ulceration induced by indomethacin or other drug in rats." | 3.67 | Quantitative analysis of intestinal ulceration induced by indomethacin, in rats. ( Ezer, E, 1987) |
| "Naloxone, an opiate antagonist, was reported to protect against stress ulcers in dogs and rats." | 3.67 | Naloxone is protective against indomethacin-induced intestinal ulceration in the rat. ( Dinari, G; Ligumsky, M; Marcus, H; Nitzan, M; Rosenbach, Y; Waisman, Y; Zahavi, I, 1985) |
| "Capsaicin desensitization increases degree and incidence of indomethacin-induced intestinal ulcers in rats, suggesting the existence of a capsaicin-sensitive mechanism(s) in the protection of the intestinal mucosa against indomethacin-induced ulceration." | 3.67 | Involvement of capsaicin-sensitive mechanism(s) in the antiulcer defence of intestinal mucosa in rats. ( Evangelista, S; Maggi, CA; Meli, A, 1987) |
| " Pelsonin a combination of indomethacin and sodium salicylate (1:10 ratio) has a cytoprotective effect against acidic-alcohol induced gastric necrosis, and it does not induce intestinal ulceration." | 3.67 | Gastrointestinal cytoprotection by indomethacin + sodium salicylate combination in rat. ( Ezer, E; Matuz, J; Pallagi, K; Szporny, L, 1984) |
| " FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug." | 3.67 | Further studies on the mechanism of fat-free diet (FFD)--protection against indomethacin-induced intestinal ulcers in the rat. ( Barzanti, A; Ciappi, R; Evangelista, S; Meli, A; Ortolani, C, 1985) |
| "Encapsulation of indomethacin into egg phosphatidylcholine (EPC) monophasic vesicles (MPV) or into stable plurilamellar vesicles (SPLV) before oral administration to rats substantially reduced or eliminated the gastric and intestinal ulceration normally associated with ingestion of this drug." | 3.67 | Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats. ( Fielder, FG; Ginsberg, RS; Godin-Ostro, E; Slusher, MA; Soehngen, EC; Weiner, AL, 1988) |
| "Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats." | 3.67 | Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat. ( Ezer, E, 1985) |
| " On the other hand, protective effects of PGM on diarrhea induced by arachidonic acid in mice were about 1/2 times as potent as those of IND in both 1 and 4 hr pretreatments." | 3.67 | [Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract]. ( Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y, 1986) |
| "An ulcerative enterocolitis was induced in dogs by two drugs; cinchophen given intravenously or indomethacin given orally." | 3.66 | Ulcerative enterocolitis in dogs induced by drugs. ( Hetenyi, C; Orizaga, M; Rowsell, H; Stewart, TH, 1980) |
| " Afterwards the different seriousness of the ulcerative lesions caused by indomethacin on normal rats and on rats kept on a diet lack of precursors of prostaglandins is weighed." | 3.66 | [Effects of indomethacin on rats kept on a normal diet and on a diet without prostaglandin precursors]. ( Agosti, C; Fasce, L; Gianfranceschi, P; Ragazzini, G, 1980) |
| "Indomethacin given orally to conventional rats produced in three days a syndrome, often fatal, of intestinal lesions characterized by multiple ulcers and peritonitis." | 3.65 | Resistance of germfree rats to indomethacin-induced intestinal lesions. ( Asano, T; Robert, A, 1977) |
| "Lafutidine (LAF) is a novel histamine H2 receptor antagonist with a mucosal protective action." | 1.91 | Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota. ( Chen, J; Chen, X; Guo, J; Liang, H; Liu, Q; Lou, C; Luo, Y; Song, C; Sun, S; Wang, B; Xu, X; Zhao, J; Zhong, W; Zhu, L, 2023) |
| "Uric acid (UA) has anti- and pro-inflammatory properties." | 1.72 | Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota. ( Akiyama, M; Hanawa, Y; Higashiyama, M; Hokari, R; Horiuchi, K; Inaba, K; Ito, S; Komoto, S; Kurihara, C; Mizoguchi, A; Nishii, S; Okada, Y; Shibuya, N; Sugihara, N; Takei, F; Tanemoto, R; Tomita, K; Wada, A; Watanabe, C, 2022) |
| "Simvastatin is an important lipid-lowering agent with anti-inflammatory activity." | 1.46 | Anti-inflammatory effects of simvastatin in nonsteroidal anti-inflammatory drugs-induced small bowel injury. ( Cho, JH; Chung, JW; Jeong, AR; Kim, EJ; Kim, EK; Kim, JH; Kim, KO; Kim, YJ; Kwon, KA; Park, DK, 2017) |
| "When indomethacin (3 mg/kg) was administered after a morning meal (fed condition) for 7 days, it produced many lesions in the small intestine." | 1.43 | Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs. ( Idaka, S; Ishigami, K; Kondo, R; Satoh, H; Shinoda, T; Shiotani, S, 2016) |
| "), a poorly absorbed antibiotic with a broad spectrum of antibacterial activity, in a rat model of enteropathy induced by indomethacin (IND, 1." | 1.43 | Small bowel protection against NSAID-injury in rats: Effect of rifaximin, a poorly absorbed, GI targeted, antibiotic. ( Antonioli, L; Bartalucci, A; Blandizzi, C; Colucci, R; Flaibani, M; Fornai, M; Ghelardi, E; Natale, G; Pellegrini, C; Renzulli, C; Sacco, D; Scarpignato, C; Tirotta, E, 2016) |
| " Vancomycin (VCM), a poorly absorbed drug, was administered intraduodenally to rats with SIUs." | 1.40 | Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers. ( Hamaguchi, T; Horibe, S; Inoue, J; Kawauchi, S; Miki, I; Mizuno, S; Nakamura, T; Nishikawa, C; Tanahashi, T; Yasui, H, 2014) |
| " Pharmacokinetic analysis of Inh-1 revealed an absolute bioavailability (F) of 21% and a short t1/2 of <1 h." | 1.40 | Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. ( Boelsterli, UA; Fujimoto, K; Lee, KK; Redinbo, MR; Saitta, KS; Zhang, C, 2014) |
| "Indomethacin (10 mg/kg) was administered orally in fasted or fed rats, and gastrointestinal lesions were examined 24 h after indomethacin administration." | 1.38 | Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility. ( Amagase, K; Satoh, H; Takeuchi, K, 2012) |
| "Indomethacin treatment markedly enhanced inducible nitric oxide synthase and chemokine mRNA expression in the small intestine, but these responses were all significantly attenuated by either domperidone or metoclopramide." | 1.37 | Dopamine D₂-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating α7 nicotinic acetylcholine receptors. ( Amagase, K; Hashimura, H; Iimori, M; Kato, S; Kawahara, R; Takeuchi, K; Yamanaka, N; Yasuda, M, 2011) |
| "Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36." | 1.36 | Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs. ( Bures, J; Kopácová, M; Kunes, M; Kvetina, J; Osterreicher, J; Pejchal, J; Rejchrt, S; Spelda, S; Tachecí, I, 2010) |
| " Mucosal lesions in the small intestine were examined 24 h after the final dosing of IND." | 1.36 | Soluble dietary fiber protects against nonsteroidal anti-inflammatory drug-induced damage to the small intestine in cats. ( Hara, T; Matsuura, M; Murakawa, D; Satoh, H; Takata, K, 2010) |
| "Pre-treatment with curcumin was found to ameliorate these drug-induced changes." | 1.35 | Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. ( Balasubramanian, KA; Basivireddy, J; Jacob, M; Sivalingam, N, 2008) |
| "Indomethacin was administered p." | 1.35 | Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent. ( Arakawa, T; Asahara, T; Fujiwara, Y; Higuchi, K; Kobata, A; Nishio, H; Nomoto, K; Oshitani, N; Shiba, M; Takeuchi, K; Tanigawa, T; Tominaga, K; Watanabe, T, 2008) |
| "Indomethacin was then administered orally at a dose of 40 mg/kg of body weight." | 1.32 | Oral glutamine attenuates indomethacin-induced small intestinal damage. ( Balasubramanian, KA; Basivireddy, J; Jacob, M, 2004) |
| " twice, 30 min before each dosing of dopamine." | 1.32 | Dopamine-induced protection against indomethacin-evoked intestinal lesions in rats--role of anti-intestinal motility mediated by D2 receptors. ( Kato, S; Matsumoto, M; Miyazawa, T; Takeuchi, K, 2003) |
| "Indomethacin was associated with electron microscopy changes suggestive of uncoupling in 60%-70% of enterocytes examined, whereas nimesulide affected 10%-30% of enterocytes, depending on the dose." | 1.30 | Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. ( Bjarnason, I; Foster, R; Jacob, M; Mahmud, T; Rafi, S; Roseth, A; Sigthorsson, G; Simpson, R; Somasundaram, S; Tavares, I; Wrigglesworth, J, 1998) |
| "Indomethacin enteropathy was evaluated using a previously described ulcer index and tissue myeloperoxidase activity." | 1.30 | Experimental enteropathy in athymic and euthymic rats: synergistic role of lipopolysaccharide and indomethacin. ( Aoyagi, K; Fujishima, M; Iida, M; Koga, H; Matsumoto, T, 1999) |
| "Indomethacin pretreatment (10 mg/kg p." | 1.27 | Protective action of SCH 12223 against experimentally induced gastric and intestinal lesions. ( Barnett, A; Brown, AD; Chiu, PJ; Gerhart, C; Siegel, M, 1988) |
| " It was shown that (1) all tested compounds inhibited the number and severity of the intestinal mucosal lesions, however, to different extent; (2) the inhibition of the development of small intestinal mucosal damage displayed a dose-response relationship; (3) 17-aza-PGF2 alpha was found to have the most potent effect on the development of the intestinal lesions as well as on the development of gastric mucosal damage produced by ethanol." | 1.27 | Preventive effect of PGI2, 7-oxo-PGI2 and 17-aza-PGF2 alpha derivate on the development of indomethacin-induced intestinal mucosal damage in rats. ( Beró, T; Garamszegi, M; Jávor, T; Mózsik, G, 1984) |
| "Indomethacin was administered subcutaneously to rats, 4 mg/kg/day for 4 consecutive days in order to produce erosions of the small intestine which were scored at necropsy on day 5." | 1.27 | Diphenyldisulfide inhibits indomethacin-induced ulcerogenesis in rats. ( Tomolonis, AJ; Young, JM, 1987) |
| "Indomethacin-treated suckling animals prevented from weaning did not develop intestinal lesions until they had access to solid food on day 23." | 1.27 | Indomethacin fails to induce ulceration in the gastrointestinal tract of newborn and suckling rats. ( Bedrick, AD; Holtzapple, PG, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (35.48) | 18.7374 |
| 1990's | 20 (16.13) | 18.2507 |
| 2000's | 28 (22.58) | 29.6817 |
| 2010's | 26 (20.97) | 24.3611 |
| 2020's | 6 (4.84) | 2.80 |
| Authors | Studies |
|---|---|
| Yamaguchi, T | 1 |
| Iijima, H | 2 |
| Yoshihara, T | 1 |
| Tani, M | 1 |
| Otake, Y | 1 |
| Iwatani, S | 1 |
| Amano, T | 1 |
| Tashiro, T | 1 |
| Kurahashi, T | 1 |
| Inoue, T | 3 |
| Tsujii, Y | 1 |
| Hayashi, Y | 3 |
| Motooka, D | 2 |
| Nakamura, S | 2 |
| Shinzaki, S | 2 |
| Takehara, T | 2 |
| Li, K | 1 |
| Cheng, X | 1 |
| Jin, R | 1 |
| Han, T | 1 |
| Li, J | 2 |
| Zhu, L | 1 |
| Guo, J | 1 |
| Liu, Q | 1 |
| Luo, Y | 1 |
| Zhao, J | 3 |
| Zhong, W | 1 |
| Sun, S | 1 |
| Xu, X | 1 |
| Liang, H | 1 |
| Lou, C | 1 |
| Song, C | 1 |
| Chen, J | 1 |
| Wang, B | 1 |
| Chen, X | 1 |
| Fornai, M | 2 |
| Colucci, R | 2 |
| Pellegrini, C | 2 |
| Benvenuti, L | 1 |
| Natale, G | 2 |
| Ryskalin, L | 1 |
| Blandizzi, C | 2 |
| Antonioli, L | 2 |
| Ganda Mall, JP | 1 |
| Fart, F | 1 |
| Sabet, JA | 1 |
| Lindqvist, CM | 1 |
| Nestestog, R | 1 |
| Hegge, FT | 1 |
| Keita, ÅV | 1 |
| Brummer, RJ | 1 |
| Schoultz, I | 1 |
| Wada, A | 1 |
| Higashiyama, M | 2 |
| Kurihara, C | 2 |
| Ito, S | 1 |
| Tanemoto, R | 1 |
| Mizoguchi, A | 1 |
| Nishii, S | 1 |
| Inaba, K | 1 |
| Sugihara, N | 1 |
| Hanawa, Y | 1 |
| Horiuchi, K | 1 |
| Shibuya, N | 1 |
| Akiyama, M | 1 |
| Okada, Y | 2 |
| Watanabe, C | 2 |
| Komoto, S | 2 |
| Tomita, K | 2 |
| Takei, F | 1 |
| Hokari, R | 2 |
| Kim, EK | 1 |
| Cho, JH | 1 |
| Jeong, AR | 1 |
| Kim, EJ | 1 |
| Park, DK | 1 |
| Kwon, KA | 1 |
| Chung, JW | 1 |
| Kim, KO | 1 |
| Kim, JH | 2 |
| Kim, YJ | 1 |
| Dorshow, RB | 1 |
| Hall-Moore, C | 1 |
| Shaikh, N | 1 |
| Talcott, MR | 1 |
| Faubion, WA | 1 |
| Rogers, TE | 1 |
| Shieh, JJ | 1 |
| Debreczeny, MP | 1 |
| Johnson, JR | 1 |
| Dyer, RB | 1 |
| Singh, RJ | 1 |
| Tarr, PI | 1 |
| Yi, D | 1 |
| Liu, W | 1 |
| Hou, Y | 1 |
| Wang, L | 1 |
| Zhao, D | 1 |
| Wu, T | 1 |
| Ding, B | 1 |
| Wu, G | 1 |
| Turkyilmaz, IB | 1 |
| Arda Pirincci, P | 1 |
| Bolkent, S | 1 |
| Yanardag, R | 1 |
| Saitta, KS | 1 |
| Zhang, C | 1 |
| Lee, KK | 1 |
| Fujimoto, K | 1 |
| Redinbo, MR | 1 |
| Boelsterli, UA | 1 |
| Gyenge, M | 1 |
| Amagase, K | 6 |
| Kunimi, S | 1 |
| Matsuoka, R | 1 |
| Takeuchi, K | 18 |
| Higashimura, Y | 1 |
| Naito, Y | 1 |
| Takagi, T | 1 |
| Tanimura, Y | 1 |
| Mizushima, K | 1 |
| Harusato, A | 1 |
| Fukui, A | 1 |
| Yoriki, H | 1 |
| Handa, O | 1 |
| Ohnogi, H | 1 |
| Yoshikawa, T | 1 |
| Kume, H | 1 |
| Okazaki, K | 1 |
| Takahashi, T | 1 |
| Yamaji, T | 1 |
| Shi, S | 1 |
| Wang, H | 2 |
| Gao, H | 1 |
| Li, Z | 1 |
| Chen, FX | 1 |
| Zuo, XL | 1 |
| Li, YQ | 1 |
| Hiyama, S | 1 |
| Shiraishi, E | 1 |
| Kawai, S | 1 |
| Araki, M | 1 |
| Kato, M | 1 |
| Nishida, T | 1 |
| Fujii, H | 1 |
| Mukai, A | 1 |
| Shibata, N | 1 |
| Sato, S | 1 |
| Kiyono, H | 1 |
| Gotoh, K | 1 |
| Iida, T | 1 |
| Tsujii, M | 1 |
| Watson, AJ | 1 |
| Kawauchi, S | 1 |
| Nakamura, T | 1 |
| Yasui, H | 1 |
| Nishikawa, C | 1 |
| Miki, I | 1 |
| Inoue, J | 1 |
| Horibe, S | 1 |
| Hamaguchi, T | 1 |
| Tanahashi, T | 1 |
| Mizuno, S | 1 |
| Chen, D | 1 |
| An, N | 1 |
| Zhou, Y | 1 |
| Fan, J | 1 |
| Luo, J | 1 |
| Su, W | 1 |
| Liu, C | 1 |
| Sacco, D | 1 |
| Tirotta, E | 1 |
| Bartalucci, A | 1 |
| Flaibani, M | 1 |
| Renzulli, C | 1 |
| Ghelardi, E | 1 |
| Scarpignato, C | 1 |
| Yoshikawa, K | 1 |
| Furuhashi, H | 1 |
| Takajo, T | 1 |
| Maruta, K | 1 |
| Yasutake, Y | 1 |
| Sato, H | 1 |
| Narimatsu, K | 1 |
| Nagao, S | 1 |
| Miura, S | 2 |
| Tajiri, H | 1 |
| Abe, N | 1 |
| Kumano, A | 1 |
| Satoh, H | 5 |
| Kondo, R | 1 |
| Shinoda, T | 1 |
| Idaka, S | 1 |
| Ishigami, K | 1 |
| Shiotani, S | 2 |
| Xiao, X | 1 |
| Nakatsu, G | 1 |
| Jin, Y | 1 |
| Wong, S | 1 |
| Yu, J | 1 |
| Lau, JY | 1 |
| Otsuka, N | 1 |
| Hatao, K | 1 |
| Nishimura, S | 1 |
| Marchbank, T | 3 |
| Limdi, JK | 1 |
| Mahmood, A | 1 |
| Elia, G | 1 |
| Playford, RJ | 3 |
| Yamato, M | 1 |
| Kataoka, Y | 1 |
| Mizuma, H | 1 |
| Wada, Y | 1 |
| Watanabe, Y | 1 |
| Watanabe-Fukuda, Y | 1 |
| Yamamoto, M | 1 |
| Miura, N | 1 |
| Fukutake, M | 1 |
| Ishige, A | 1 |
| Yamaguchi, R | 1 |
| Nagasaki, M | 1 |
| Saito, A | 1 |
| Imoto, S | 1 |
| Miyano, S | 1 |
| Takeda, J | 1 |
| Watanabe, K | 3 |
| Hara, T | 1 |
| Murakawa, D | 1 |
| Matsuura, M | 1 |
| Takata, K | 1 |
| Watanabe, T | 2 |
| Nishio, H | 5 |
| Tanigawa, T | 2 |
| Yamagami, H | 1 |
| Okazaki, H | 1 |
| Tominaga, K | 2 |
| Fujiwara, Y | 2 |
| Oshitani, N | 2 |
| Asahara, T | 2 |
| Nomoto, K | 2 |
| Higuchi, K | 3 |
| Arakawa, T | 3 |
| Tachecí, I | 1 |
| Kvetina, J | 1 |
| Bures, J | 1 |
| Osterreicher, J | 1 |
| Kunes, M | 1 |
| Pejchal, J | 1 |
| Rejchrt, S | 1 |
| Spelda, S | 1 |
| Kopácová, M | 1 |
| Imaoka, H | 1 |
| Ishihara, S | 1 |
| Kazumori, H | 1 |
| Kadowaki, Y | 1 |
| Aziz, MM | 1 |
| Rahman, FB | 1 |
| Ose, T | 1 |
| Fukuhara, H | 1 |
| Takasawa, S | 1 |
| Kinoshita, Y | 1 |
| Yoda, Y | 1 |
| Kato, S | 8 |
| Tokioka, S | 1 |
| Murano, M | 1 |
| Kakimoto, K | 1 |
| Umegaki, E | 1 |
| Yasuda, M | 2 |
| Kawahara, R | 1 |
| Hashimura, H | 1 |
| Yamanaka, N | 1 |
| Iimori, M | 1 |
| Matsuda, N | 1 |
| Matsumoto, K | 1 |
| Wada, M | 1 |
| Onimaru, N | 1 |
| Horie, S | 1 |
| Patel, MR | 1 |
| DeMarco, VG | 1 |
| Clare-Salzler, M | 1 |
| Li, YY | 1 |
| Neu, J | 1 |
| Miyazawa, T | 2 |
| Matsumoto, M | 1 |
| Yasuoka, T | 1 |
| Sasaki, M | 1 |
| Fukunaga, T | 1 |
| Tsujikawa, T | 1 |
| Fujiyama, Y | 1 |
| Kushima, R | 1 |
| Goodlad, RA | 2 |
| Porras, M | 1 |
| Martín, MT | 1 |
| Soler, M | 1 |
| Vergara, P | 1 |
| Basivireddy, J | 2 |
| Jacob, M | 4 |
| Balasubramanian, KA | 2 |
| Yokota, A | 2 |
| Taniguchi, M | 1 |
| Takahira, Y | 2 |
| Tanaka, A | 6 |
| Imai, T | 1 |
| Onose, J | 1 |
| Hasumura, M | 1 |
| Takizawa, T | 1 |
| Hirose, M | 1 |
| Hatazawa, R | 2 |
| Ohno, R | 1 |
| Tanigami, M | 1 |
| Yang, Z | 1 |
| Nandi, J | 2 |
| Wang, J | 1 |
| Bosco, G | 1 |
| Gregory, M | 1 |
| Chung, C | 1 |
| Xie, Y | 1 |
| Yang, X | 1 |
| Camporesi, EM | 1 |
| Ogura, M | 1 |
| Fujiyama, N | 1 |
| Shitara, Y | 1 |
| Ito, K | 1 |
| Masubuchi, Y | 1 |
| Horie, T | 1 |
| Kamil, R | 1 |
| Geier, MS | 1 |
| Butler, RN | 1 |
| Howarth, GS | 1 |
| Kobata, A | 1 |
| Shiba, M | 1 |
| Sivalingam, N | 1 |
| Terashima, S | 1 |
| Kamei, K | 1 |
| Kubo, Y | 1 |
| Kato, N | 1 |
| Stewart, TH | 1 |
| Hetenyi, C | 1 |
| Rowsell, H | 1 |
| Orizaga, M | 1 |
| Ezer, E | 4 |
| Szporny, L | 2 |
| Evangelista, S | 3 |
| Meli, A | 6 |
| Garamszegi, M | 1 |
| Beró, T | 2 |
| Jávor, T | 2 |
| Mózsik, G | 2 |
| Topalian, SL | 1 |
| Ziegler, MM | 1 |
| Németh, A | 1 |
| Matuz, J | 1 |
| Pallagi, K | 1 |
| Gago, E | 1 |
| Liaño, F | 1 |
| Quiñones, L | 1 |
| Velasco, J | 1 |
| Alvarez Grande, J | 1 |
| Whittle, BJ | 1 |
| Chono, S | 1 |
| Yamada, H | 1 |
| Nakamura, H | 1 |
| Kobayashi, K | 1 |
| Ishihara, Y | 1 |
| Okabe, S | 2 |
| Tsurumi, K | 1 |
| Kyuki, K | 1 |
| Fujimura, H | 2 |
| Tabata, K | 1 |
| Gianfranceschi, P | 1 |
| Ragazzini, G | 1 |
| Agosti, C | 1 |
| Fasce, L | 1 |
| Zahavi, I | 3 |
| Fisher, S | 1 |
| Marcus, H | 3 |
| Heckelman, B | 1 |
| Kiro, A | 2 |
| Dinari, G | 3 |
| Nygård, G | 2 |
| Hudson, M | 2 |
| Mazure, G | 1 |
| Anthony, A | 3 |
| Dhillon, AP | 2 |
| Pounder, RE | 2 |
| Wakefield, AJ | 1 |
| Matsumoto, T | 3 |
| Iida, M | 3 |
| Kuroki, F | 2 |
| Hizawa, K | 1 |
| Koga, H | 2 |
| Fujishima, M | 2 |
| Okabe, H | 1 |
| Sakamoto, S | 1 |
| Chijiiwa, Y | 1 |
| Misawa, T | 1 |
| Nawata, H | 1 |
| Nakayama, K | 1 |
| Perkins, WE | 1 |
| Bianchi, RG | 1 |
| Tremont, SJ | 1 |
| Collins, PW | 1 |
| Casler, JJ | 1 |
| Fenton, RL | 1 |
| Wagner, GM | 1 |
| McGrath, MP | 1 |
| Stolzenbach, JC | 1 |
| Kowalski, DL | 1 |
| Piasecki, C | 1 |
| Strong, P | 1 |
| Trevethick, MA | 1 |
| Clayton, NM | 1 |
| Jordan, CC | 1 |
| Somasundaram, S | 2 |
| Rafi, S | 2 |
| Hayllar, J | 1 |
| Sigthorsson, G | 3 |
| Price, AB | 1 |
| Macpherson, A | 1 |
| Mahmod, T | 1 |
| Scott, D | 1 |
| Wrigglesworth, JM | 1 |
| Bjarnason, I | 3 |
| Antoon, JS | 1 |
| Perry, MA | 1 |
| Schmassmann, A | 1 |
| Peskar, BM | 1 |
| Stettler, C | 1 |
| Netzer, P | 1 |
| Stroff, T | 1 |
| Flogerzi, B | 1 |
| Halter, F | 1 |
| Wrigglesworth, J | 1 |
| Tavares, I | 1 |
| Foster, R | 2 |
| Roseth, A | 1 |
| Mahmud, T | 1 |
| Simpson, R | 1 |
| Aoyagi, K | 1 |
| Honda, K | 1 |
| Oka, M | 1 |
| Sawatani, I | 1 |
| Konaka, A | 1 |
| Kunikata, T | 2 |
| Korolkiewicz, R | 1 |
| Cox, HM | 1 |
| Giraud, AS | 1 |
| Moss, SF | 1 |
| Poulsom, R | 1 |
| Wright, NA | 1 |
| Jankowski, J | 1 |
| MacDonald, CE | 1 |
| Calnan, DP | 1 |
| Floyd, DN | 1 |
| Podas, T | 1 |
| Johnson, W | 1 |
| Wicks, AC | 1 |
| Bashir, O | 1 |
| Mizoguchi, H | 1 |
| Ogawa, Y | 1 |
| Kanatsu, K | 1 |
| Parasher, G | 1 |
| Frenklakh, L | 1 |
| Siddiqui, T | 1 |
| Levine, RA | 1 |
| Simpson, RJ | 1 |
| Walley, M | 1 |
| Hotz-Behoftsitz, C | 1 |
| Palizban, A | 1 |
| Pombo, J | 1 |
| Watts, J | 1 |
| Morham, SG | 1 |
| Carminati, GM | 1 |
| Robert, A | 1 |
| Asano, T | 1 |
| Kauffman, GL | 1 |
| Foley, KT | 1 |
| Grossman, MI | 1 |
| Sobocinski, PZ | 1 |
| Knutsen, GL | 1 |
| Canterbury, WJ | 1 |
| Hauer, EC | 1 |
| Volterra, G | 2 |
| Del Soldato, P | 3 |
| Soldato, PD | 1 |
| Maruyama, Y | 1 |
| Terasawa, M | 1 |
| Anami, K | 1 |
| Kadobe, Y | 1 |
| Nakamura, J | 1 |
| Katayama, M | 1 |
| Nishida, K | 1 |
| Sasaki, H | 1 |
| Melarange, R | 1 |
| Moore, G | 1 |
| Blower, PR | 1 |
| Coates, ME | 1 |
| Ward, FW | 1 |
| Ronaasen, V | 1 |
| Suematsu, M | 1 |
| Tanaka, S | 1 |
| Nagata, H | 1 |
| Houzawa, S | 1 |
| Suzuki, M | 1 |
| Kurose, I | 1 |
| Serizawa, H | 1 |
| Tsuchiya, M | 1 |
| Sugiyama, K | 1 |
| Bamba, T | 1 |
| Nakajo, S | 1 |
| Hosoda, S | 1 |
| Davies, GR | 1 |
| Rampton, DS | 1 |
| Fracasso, ME | 1 |
| Leone, R | 1 |
| Cuzzolin, L | 1 |
| Velo, GP | 1 |
| Benoni, G | 1 |
| Gibson, PR | 1 |
| Jewell, DP | 1 |
| Kramarev, SA | 1 |
| Foschi, D | 1 |
| Varin, L | 1 |
| Daniotti, S | 1 |
| Hidaka, T | 1 |
| Hosoe, K | 1 |
| Yamashita, T | 1 |
| Hiramatsu, Y | 1 |
| Waisman, Y | 1 |
| Ligumsky, M | 1 |
| Rosenbach, Y | 1 |
| Nitzan, M | 1 |
| Ono, N | 1 |
| Yamasaki, Y | 1 |
| Yamamoto, N | 1 |
| Sunami, A | 1 |
| Miyake, H | 1 |
| Soehngen, EC | 1 |
| Godin-Ostro, E | 1 |
| Fielder, FG | 1 |
| Ginsberg, RS | 1 |
| Slusher, MA | 1 |
| Weiner, AL | 1 |
| Chiu, PJ | 1 |
| Barnett, A | 1 |
| Siegel, M | 1 |
| Brown, AD | 1 |
| Gerhart, C | 1 |
| Knoll, J | 1 |
| Gyires, K | 1 |
| Hermecz, I | 1 |
| Young, JM | 1 |
| Tomolonis, AJ | 1 |
| Bedrick, AD | 1 |
| Holtzapple, PG | 1 |
| Maggi, CA | 1 |
| Weissenborn, U | 1 |
| Maedge, S | 1 |
| Buettner, D | 1 |
| Sewing, KF | 1 |
| Ciappi, R | 1 |
| Ortolani, C | 1 |
| Barzanti, A | 1 |
| Somogyi, A | 1 |
| Kovács, K | 1 |
| Selye, H | 3 |
| Pisanti, N | 1 |
| Drees, DT | 1 |
| Robbins, TL | 1 |
| Crago, FL | 1 |
| Brodie, DA | 1 |
| Cook, PG | 1 |
| Bauer, BJ | 1 |
| Dagle, GE | 1 |
| Solymoss, B | 1 |
| Toth, S | 1 |
| Varga, S | 1 |
| Kent, TH | 1 |
| Cardelli, RM | 1 |
| Stamler, FW | 1 |
2 reviews available for indomethacin and Intestinal Diseases
| Article | Year |
|---|---|
Role of dietary fiber in formation and prevention of small intestinal ulcers induced by nonsteroidal anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fiber; Eating; Gastrointestinal Motility; | 2010 |
Necrotizing enterocolitis: a review of animal models.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Bacterial Physiological Phenomena; Blood Volume; Bre | 1984 |
3 trials available for indomethacin and Intestinal Diseases
| Article | Year |
|---|---|
Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial.
Topics: Acute Disease; Aged; Aged, 80 and over; Avena; beta-Glucans; Dietary Fiber; Dietary Supplements; Fem | 2020 |
Clinical trial: protective effect of a commercial fish protein hydrolysate against indomethacin (NSAID)-induced small intestinal injury.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Dietary Supplements; Double-Blin | 2008 |
Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.
Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Colostrum; Cross-Over Studies | 2001 |
119 other studies available for indomethacin and Intestinal Diseases
| Article | Year |
|---|---|
Exacerbation of non-steroidal anti-inflammatory drug-induced enteropathy in C-C chemokine receptor type 7-deficient mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dendritic Cells; Indomethacin; Intestinal Diseases | 2022 |
The influence of different proton pump inhibitors and potassium-competitive acid blockers on indomethacin-induced small intestinal injury.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; DNA, Ribo | 2022 |
Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Inflammation; Intestinal Diseases; I | 2023 |
Role of proteinase-activated receptors 1 and 2 in nonsteroidal anti-inflammatory drug enteropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Ileum; Indomethacin; Intestinal Disease | 2020 |
Protective Effect of Luminal Uric Acid Against Indomethacin-Induced Enteropathy: Role of Antioxidant Effect and Gut Microbiota.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Fecal Microb | 2022 |
Anti-inflammatory effects of simvastatin in nonsteroidal anti-inflammatory drugs-induced small bowel injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 1; Cycloox | 2017 |
Measurement of gut permeability using fluorescent tracer agent technology.
Topics: Animals; Disease Models, Animal; Fluorescent Dyes; Gastrointestinal Tract; Indomethacin; Intestinal | 2017 |
Establishment of a porcine model of indomethacin-induced intestinal injury.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enterocytes; Fatty Acid-Binding Proteins; Gene Ex | 2018 |
The effects of vitamins and selenium mixture or ranitidine against small intestinal injury induced by indomethacin in adult rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Humans; Indomethacin; Intestinal Di | 2019 |
Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Diclofenac; Enzyme Inhibit | 2014 |
Roles of pro-angiogenic and anti-angiogenic factors as well as matrix metalloproteinases in healing of NSAID-induced small intestinal ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Endostatins; Indomethacin; Intestinal Diseases; In | 2013 |
Preventive effect of agaro-oligosaccharides on non-steroidal anti-inflammatory drug-induced small intestinal injury in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginase; beta-N-Acetylhexos | 2014 |
Protective effect of an immune-modulating diet comprising whey peptides and fermented milk products on indomethacin-induced small-bowel disorders in rats.
Topics: Animals; Bacterial Translocation; Dairy Products; Diet; Dinoprostone; Disease Models, Animal; Fermen | 2014 |
Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Biomarkers; Blotting, Western; | 2014 |
Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD4-Positive T-Lymphocytes; Cell Differentiation; | 2014 |
Confocal laser endomicroscopy and NSAID enteropathy: where next?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Goblet Cells; Indomethacin; Intestinal Diseases; I | 2014 |
Intestinal and hepatic expression of cytochrome P450s and mdr1a in rats with indomethacin-induced small intestinal ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassett | 2014 |
Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury.
Topics: Animals; Antineoplastic Agents; Calcium; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Mo | 2015 |
Small bowel protection against NSAID-injury in rats: Effect of rifaximin, a poorly absorbed, GI targeted, antibiotic.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; DNA, Bacterial; Firmicutes; | 2016 |
Psychological stress exacerbates NSAID-induced small bowel injury by inducing changes in intestinal microbiota and permeability via glucocorticoid receptor signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Gastrointestinal Microbiom | 2017 |
Influence of Adrenalectomy on Protective Effects of Urocortin I, a Corticotropin-Releasing Factor, Against Indomethacin-Induced Enteropathy in Rats.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Respon | 2016 |
Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Dietary Fiber; Dietary Supplements; Dog | 2016 |
Gut Microbiota Mediates Protection Against Enteropathy Induced by Indomethacin.
Topics: Animals; Anti-Bacterial Agents; Gastrointestinal Microbiome; Indomethacin; Intestinal Diseases; Inte | 2017 |
Role of dietary fibres, intestinal hypermotility and leukotrienes in the pathogenesis of NSAID-induced small intestinal ulcers in cats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Diet; Dietary Fiber; Duodenal Ulcer; Eating; | 2009 |
PET and macro- and microautoradiographic studies combined with immunohistochemistry for monitoring rat intestinal ulceration and healing processes.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoradiography; Fluorine Radioisotopes; Fluorodeo | 2009 |
Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adenosine Deaminase; Alkaloids; Animals; Anti-Inflamma | 2009 |
Soluble dietary fiber protects against nonsteroidal anti-inflammatory drug-induced damage to the small intestine in cats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Chromatography, High P | 2010 |
Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid.
Topics: Animals; Cell Line; Disease Models, Animal; Humans; I-kappa B Proteins; Indomethacin; Intestinal Dis | 2009 |
Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Disease Models, Animal; Duodena | 2010 |
Exacerbation of indomethacin-induced small intestinal injuries in Reg I-knockout mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Interleukin-1beta; Intestinal Diseas | 2010 |
Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colony Co | 2010 |
Dopamine D₂-receptor antagonists ameliorate indomethacin-induced small intestinal ulceration in mice by activating α7 nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2011 |
Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Ulcer Agents; Benzamides; Fencloni | 2012 |
Exacerbation of nonsteroidal anti-inflammatory drug-induced small intestinal lesions by antisecretory drugs in rats: the role of intestinal motility.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Capsaicin; Dose-Response | 2012 |
Indomethacin, dexamethasone, and intestinal damage in infant rats.
Topics: Age Factors; Animals; Animals, Suckling; Cyclooxygenase Inhibitors; Dexamethasone; Female; Food, For | 2002 |
Dopamine-induced protection against indomethacin-evoked intestinal lesions in rats--role of anti-intestinal motility mediated by D2 receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Domperidon | 2003 |
The effects of lectins on indomethacin-induced small intestinal ulceration.
Topics: Animals; Cell Division; Concanavalin A; Food, Formulated; Indomethacin; Intestinal Diseases; Intesti | 2003 |
Intestinal motor disorders associated with cyclical bacterial overgrowth in a rat model of enteritis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Bacterial Infections; Bac | 2004 |
Oral glutamine attenuates indomethacin-induced small intestinal damage.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Glucose; Glutamine; Indometh | 2004 |
Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Colony Count, Microbial; Cyclooxygenase | 2005 |
Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Amitrole; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Carcinogens; Cocarcinogenes | 2006 |
Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats.
Topics: Animals; Blood Vessels; Carmine; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cy | 2006 |
Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Progression; Electrophoresis, Polyacrylamide Ge | 2006 |
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoproston | 2006 |
Tacrolimus (FK506), an immunosuppressive agent, prevents indomethacin-induced small intestinal ulceration in the rat: inhibition of inducible nitric oxide synthase expression.
Topics: Animals; Immunosuppressive Agents; Indomethacin; Intestinal Diseases; Lipid Peroxidation; Male; NF-k | 2007 |
Down-regulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury.
Topics: Alanine Transaminase; Animals; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Coloring | 2007 |
Lactobacillus rhamnosus GG exacerbates intestinal ulceration in a model of indomethacin-induced enteropathy.
Topics: Animals; Apoptosis; Bifidobacterium; Cell Proliferation; Disease Models, Animal; Indomethacin; Intes | 2007 |
Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Indomethacin; Intestinal Diseas | 2008 |
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Indomethacin; Inte | 2008 |
Protective effect of pranlukast, a cysteinyl-leukotriene receptor 1 antagonist, on indomethacin-induced small intestinal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Translocation; Capillary Permeability; C | 2007 |
Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclic Nucleotide Phosphodieste | 2008 |
Ulcerative enterocolitis in dogs induced by drugs.
Topics: Animals; Colitis; Dogs; Enteritis; Female; Indomethacin; Intestinal Diseases; Male; Peyer's Patches; | 1980 |
Comparison of the effects of solium salicylate with anti-ulcer agents in preventing indomethacin-induced intestinal ulcer.
Topics: Animals; Anti-Ulcer Agents; Female; Indomethacin; Intestinal Diseases; Intestine, Small; Rats; Sodiu | 1981 |
On the relationship between ulcerogenic and anti-inflammatory properties of indomethacin.
Topics: Animals; Edema; Indomethacin; Intestinal Diseases; Male; Rats; Rats, Inbred Strains; Ulcer | 1983 |
Preventive effect of PGI2, 7-oxo-PGI2 and 17-aza-PGF2 alpha derivate on the development of indomethacin-induced intestinal mucosal damage in rats.
Topics: Animals; Dinoprost; Epoprostenol; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Prostaglandi | 1984 |
The effect of gastric cytoprotective drugs (atropine, cimetidine, vitamin-A) on the indomethacin induced intestinal ulcers in rats.
Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Indomethacin; Intestinal Diseases; | 1984 |
Gastrointestinal cytoprotection by indomethacin + sodium salicylate combination in rat.
Topics: Animals; Drug Combinations; Ethanol; Female; Gastric Mucosa; Indomethacin; Intestinal Diseases; Inte | 1984 |
[Intestinal ulcers in hemodialysis].
Topics: Adult; Humans; Indomethacin; Intestinal Diseases; Male; Renal Dialysis; Ulcer | 1983 |
Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Epoprostenol; Indomethacin; Intestinal Diseases; Male; | 1981 |
[The role of endogenous prostaglandin in drug-induced gastrointestinal lesions--comparison of aspirin and indomethacin (author's transl)].
Topics: Animals; Aspirin; Dinoprostone; Gastric Mucosa; Indomethacin; Intestinal Diseases; Intestinal Mucosa | 1981 |
Effects of cholestyramine and synthetic hydrotalcite on acute gastric or intestinal lesion formation in rats and dogs.
Topics: Aluminum Hydroxide; Animals; Antacids; Carbonates; Cholestyramine Resin; Dogs; Female; Indomethacin; | 1981 |
Interaction of indomethacin and aspirin or mepirizole in rats as shown by gastrointestinal ulcerogenic and anti-inflammatory activities.
Topics: Animals; Aspirin; Biological Transport; Charcoal; Drug Interactions; Edema; Epirizole; Indomethacin; | 1980 |
Effects of 16, 16-dimethyl prostaglandin E2 methyl ester on aspirin-and indomethacin-induced gastrointestinal lesions in dogs.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Dogs; Gastric Mucosa; Indomethacin; Intestinal Dis | 1980 |
[Effects of indomethacin on rats kept on a normal diet and on a diet without prostaglandin precursors].
Topics: Animals; Dietary Fats; Indomethacin; Intestinal Diseases; Intestines; Prostaglandins; Rats; Ulcer | 1980 |
Oxygen radical scavengers are protective against indomethacin-induced intestinal ulceration in the rat.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Free Radical Scavengers; In | 1995 |
Procoagulant and prothrombotic responses of human endothelium to indomethacin and endotoxin in vitro. Relevance to non-steroidal anti-inflammatory drug enteropathy.
Topics: 6-Ketoprostaglandin F1 alpha; Anti-Inflammatory Agents, Non-Steroidal; Blood Coagulation Factors; Ce | 1995 |
Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes.
Topics: Animals; Diet; Food, Formulated; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Leukotriene B | 1994 |
[A case of ankylosing spondylitis with secondary intestinal amyloidosis].
Topics: Adult; Amyloidosis; Humans; Indomethacin; Intestinal Diseases; Male; Spondylitis, Ankylosing | 1994 |
Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem.
Topics: Animals; Antacids; Aspirin; Biological Availability; Butadienes; Depression, Chemical; Diarrhea; Dog | 1994 |
Early histological features of small intestinal injury induced by indomethacin.
Topics: Animals; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Jejunal Diseases; J | 1993 |
Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine.
Topics: Acetaminophen; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bile | 1997 |
Role of neutrophils and mast cells in acute indomethacin-induced small bowel injury in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromium Radioisotopes; Dexamethasone; Edetic Acid | 1997 |
Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dicl | 1998 |
Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Membrane Permeability; Cyclooxygenase Inhibit | 1998 |
Experimental enteropathy in athymic and euthymic rats: synergistic role of lipopolysaccharide and indomethacin.
Topics: Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Synergism; Endotoxins; Germ-F | 1999 |
Protective effect of lactosucrose on intracolonic indomethacin-induced small-intestinal ulcers in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Intestinal Diseases; Intestine, Smal | 1999 |
Roles of enterobacteria, nitric oxide and neutrophil in pathogenesis of indomethacin-induced small intestinal lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Enterobacteriaceae; Guanidines; Indomethacin; Inte | 1999 |
Effect of ectopic expression of rat trefoil factor family 3 (intestinal trefoil factor) in the jejunum of transgenic mice.
Topics: Animals; Apoptosis; Artificial Gene Fusion; Carrier Proteins; Cell Division; Cell Movement; Fatty Ac | 2001 |
Protective effect of rebamipide on indomethacin-induced intestinal damage in rats.
Topics: Alanine; Ampicillin; Animals; Anti-Ulcer Agents; Bacterial Translocation; Catalase; Dose-Response Re | 2001 |
Nitric oxide inhibitors ameliorate indomethacin-induced enteropathy in rats.
Topics: Amidines; Animals; Benzylamines; Blotting, Western; Enzyme Inhibitors; Guanidines; Indomethacin; Int | 2001 |
16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Colony Count, Microbial; Cyclooxygenase Inhibitors; Gastroi | 2002 |
COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2002 |
[Protective activity of zolimidine against 2 different types of experimental ulcers of the intestine].
Topics: Animals; Carrageenan; Drug Evaluation, Preclinical; Guinea Pigs; Indomethacin; Intestinal Diseases; | 1978 |
Resistance of germfree rats to indomethacin-induced intestinal lesions.
Topics: Animals; Escherichia coli; Female; Germ-Free Life; Indomethacin; Intestinal Diseases; Intestines; Ma | 1977 |
Cimetidine does not inhibit indomethacin-induced small bowel ulceration in the rat.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Cimetidine; Guanidines; Indomethacin; Intestinal Diseases; | 1979 |
Altered zinc homeostasis and hepatic accumulation of metallothionein in indomethacin-induced enteropathy.
Topics: Animals; Homeostasis; Indomethacin; Intestinal Absorption; Intestinal Diseases; Liver; Male; Metallo | 1979 |
Indomethacin: relationship between ulcerogenic and anti-inflammatory properties. I. Effects of an intestinal lesion-preventing fat-free diet on anti-edema and anti-granuloma properties of indomethacin in the rat.
Topics: Animals; Body Weight; Dietary Fats; Edema; Fatty Acids, Essential; Granuloma; Indomethacin; Inflamma | 1978 |
Studies on the mechanism of fat-free diet (FFD) protection against indomethacin-induced intestinal ulcers.
Topics: Animals; Bile; Dietary Fats; Female; Glucaric Acid; Glucuronidase; Indomethacin; Intestinal Diseases | 1978 |
[Pharmacological studies of 2-(5H-(1)benzopyrano(2,3-b)pyridin-7-yl)propionic acid (Y-8004). (I) Anti-inflammatory, analgesic and antipyretic actions].
Topics: Adrenal Cortex; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability | 1975 |
L-dopa is protective against indomethacin-induced small intestinal ulceration in the rat: possible role of an alpha-2-adrenergic mechanism.
Topics: Animals; Clonidine; Haloperidol; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Levodopa; Mal | 1992 |
An assessment of indomethacin-induced mucosal damage in vivo by measuring the metabolism of salicylamide in rabbit intestine.
Topics: Animals; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestines; Male; Rabbits; Salicylami | 1992 |
A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats.
Topics: Animals; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Germ-Free Life; Ibuprofen; Indomethaci | 1992 |
Microcirculatory disturbance in indomethacin-induced intestinal ulcer.
Topics: Animals; Benzoquinones; Chromones; Fluorescein-5-isothiocyanate; Fluoresceins; Indomethacin; Intesti | 1991 |
[A study on the mechanism of indomethacin induced intestinal ulcer--from a viewpoint of unstirred water layer].
Topics: Animals; Body Water; Glycoproteins; Indomethacin; Intestinal Diseases; Intestine, Small; Male; Rats; | 1991 |
The pro-drug sulindac may reduce the risk of intestinal damage associated with the use of conventional non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Edetic Acid; Humans; Indo | 1991 |
Indomethacin induced hepatic alterations in mono-oxygenase system and faecal Clostridium perfringens enterotoxin in the rat.
Topics: Aminopyrine N-Demethylase; Animals; Clostridium perfringens; Cytochrome P-450 Enzyme System; Cytochr | 1990 |
The nature of the natural killer (NK) cell of human intestinal mucosa and mesenteric lymph node.
Topics: Antioxidants; Catechols; Cell Separation; Complement System Proteins; Cyclic AMP; Cytotoxicity, Immu | 1985 |
[The use of indomethacin in acute intestinal infections].
Topics: Acute Disease; Bacterial Infections; Child, Preschool; Convalescence; Dinoprost; Drug Evaluation; Hu | 1989 |
Indomethacin-induced intestinal ulcers in rats: effects of salicylazosulfapyridine and dexamethasone.
Topics: Animals; Dexamethasone; Female; Indomethacin; Inflammation; Intestinal Diseases; Rats; Sulfasalazine | 1985 |
Analgesic and anti-inflammatory activities in rats of alpha-(3,5-di-t-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), and its intestinal damage.
Topics: 4-Butyrolactone; Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 1986 |
Naloxone is protective against indomethacin-induced intestinal ulceration in the rat.
Topics: Animals; Cimetidine; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Intes | 1985 |
[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (3) Damaging effects on the gastrointestinal tract].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidoni | 1986 |
Encapsulation of indomethacin in liposomes provides protection against both gastric and intestinal ulceration when orally administered to rats.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Administration, Oral; Animals; Biological Availability; Freeze F | 1988 |
Protective action of SCH 12223 against experimentally induced gastric and intestinal lesions.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Aspirin; Ethanol; Gastric Mucosa; Indomethacin; In | 1988 |
1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido(1,2-a)- pyrimidine-3-carboxamide (Ch-127) protects against the intestinal damage in rats caused by two weeks' daily administration of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Indomethacin; Intestinal Diseas | 1987 |
Quantitative analysis of intestinal ulceration induced by indomethacin, in rats.
Topics: Animals; Female; Indomethacin; Intestinal Diseases; Intestine, Small; Rats; Rats, Inbred Strains; Te | 1987 |
Diphenyldisulfide inhibits indomethacin-induced ulcerogenesis in rats.
Topics: Animals; Disulfides; Indomethacin; Intestinal Diseases; Lipoxygenase Inhibitors; Male; Rats; Ulcer | 1987 |
Indomethacin fails to induce ulceration in the gastrointestinal tract of newborn and suckling rats.
Topics: Animals; Animals, Newborn; Indomethacin; Intestinal Diseases; Prostaglandins; Rats; Rats, Inbred Str | 1986 |
Involvement of capsaicin-sensitive mechanism(s) in the antiulcer defence of intestinal mucosa in rats.
Topics: Animals; Capsaicin; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Male; Rats; Rats, Inbred S | 1987 |
Indometacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat.
Topics: Animals; Body Weight; Eating; Female; Gastric Fundus; Gastric Mucosa; Indomethacin; Intestinal Disea | 1985 |
Further studies on the mechanism of fat-free diet (FFD)--protection against indomethacin-induced intestinal ulcers in the rat.
Topics: Animals; Dietary Fats; Indomethacin; Intestinal Diseases; Intestines; Male; Rats; Rats, Inbred Strai | 1985 |
Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Eating; Female; Indomethacin; Intestinal Disease | 1985 |
Jejunal ulcers produced by indomethacin.
Topics: Animals; Female; Indomethacin; Intestinal Diseases; Jejunum; Rats; Ulcer | 1969 |
Prevention of indomethacin-induced intestinal ulcers by various catatoxic steroids.
Topics: Adrenal Cortex Hormones; Animals; Antitoxins; Chemical Phenomena; Chemistry; Corticosterone; Ethyles | 1970 |
Factors influencing the development of indomethacin-induced intestinal ulcers in the rat.
Topics: 1-Propanol; Animals; Cholagogues and Choleretics; Dietary Fats; Female; Indomethacin; Intestinal Dis | 1974 |
Effect of low-residue foods on indomethacin-induced intestinal lesions in rats.
Topics: Animal Feed; Animals; Cellulose; Diet; Digestion; Female; Indomethacin; Intestinal Diseases; Male; R | 1974 |
Indomethacin-induced intestinal lesions in the rat.
Topics: Administration, Oral; Animals; Antacids; Aspirin; Atropine; Bile Ducts; Bretylium Compounds; Chlorpr | 1970 |
Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication.
Topics: Animals; Digitoxin; Drug Antagonism; Female; Indomethacin; Intestinal Diseases; Jejunum; Microsomes, | 1971 |
Small intestinal ulcers and intestinal flora in rats given indomethacin.
Topics: Animals; Anti-Bacterial Agents; Cecal Diseases; Ileum; Indomethacin; Intestinal Diseases; Intestine, | 1969 |