indomethacin has been researched along with Innate Inflammatory Response in 846 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1% indomethacin and gentamicin proved to be effective and well tolerated in preventing inflammation after cataract surgery." | 9.08 | [Efficacy and tolerability of a combination of indomethacin and gentamicin for preventing inflammation after cataract surgery]. ( Adenis, JP; Allaire, C; Brasseur, G; Couderc, JL; Dascotte, JC; Hoang-Xuan, T; Renard, G; Rouland, JF; Trinquand, C; Ullern, M, 1996) |
| "1% diclofenac, in the management of post cataract surgery inflammation." | 9.08 | [Double-blind study on 3 parallel groups of 2 formulations of 0.1% indomethacin and 0.1% diclofenac in preventing and controlling inflammation after cataract surgery]. ( Arnaud, B; Trinquand, C, 1997) |
| "Preliminary findings are reported from an open study of 300 mg flurbiprofen daily in 24 patients and from 6 out of 30 patients treated so far in a double-blind crossover comparison of 300 mg flurbiprofen daily and 150 mg indomethacin daily in the treatment of rheumatoid arthritis." | 9.04 | Flurbiprofen in rheumatoid arthritis therapy. ( Loizzi, P; Numo, R; Pipitone, V, 1977) |
| "This experiment aimed to investigate the preventive effect of ethanol extract (RM) from Chinese sumac fruits on indomethacin-induced gastric ulcer in mice and the underlying mechanisms." | 8.12 | Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis. ( Cai, S; Ma, N; Sun, Y; Yi, J; Zhou, L, 2022) |
| " The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy." | 8.02 | Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021) |
| " This study implies the therapeutic effect of IND and juglone [JUG] against colon carcinogenesis, without gastric ulceration - an adverse side effect of IND." | 8.02 | Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis. ( Devaraj, H; Seetha, A; Sudhandiran, G, 2021) |
| " chamomilla extract (MCE) with two NSAIDs, diclofenac and indomethacin on carrageenan-induced paw inflammation and gastric injury in rats." | 7.85 | Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan-Induced Paw Inflammation in Rats. ( Cariño-Cortés, R; Castañeda-Hernández, G; González-García, MP; Ortiz, MI; Ponce-Monter, HA; Salinas-Caballero, M, 2017) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 7.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| "Cu-Indo gel at lower doses was superior to or at least as effective as its parent substance, indomethacin, in most of the studied parameters of inflammation." | 7.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| " Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test." | 7.79 | Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. ( Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA, 2013) |
| " The present study aimed to assess the role of cysteinyl leukotriene receptor antagonist on peripheral inflammation and whether montelukast treatment enhances the anti-inflammatory effect of indomethacin." | 7.79 | Potentiation of indomethacin-induced anti-inflammatory response by montelukast in formalin-induced inflammation in rats. ( Behmanesh, MA; Ghorbanzadeh, B; Hemmati, AA, 2013) |
| "We investigated the effect of argirein on acute inflammation edema and examined that aquaporin 4 (AQP4), p66Shc and activating transcription factor (ATF-6) might be involved in carrageenan-induced rat paw inflammation and be reversed by argirein, rhein and indometacin, but not L-arginine." | 7.78 | Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| "Anti-inflammatory and antioxidative potential of hesperidin and naringin was carried out considering the rat air pouch model of inflammation." | 7.77 | Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. ( Jain, M; Parmar, HS, 2011) |
| " We also evaluated whether an anti-inflammatory drug could prevent or diminish METH-induced neuroinflammation, and we concluded that indomethacin (10 mg/kg; i." | 7.76 | Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin. ( Baptista, S; Borges, F; Gonçalves, J; Malva, JO; Martins, T; Milhazes, N; Ribeiro, CF; Silva, AP, 2010) |
| "We conclude that ATL-313 does not inhibit the mucosal damaging effect of indomethacin, but it does block secondary injury due to stomach inflammation." | 7.75 | Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. ( Jin, M; Koizumi, S; Linden, J; Odashima, M; Ohnishi, H; Otaka, M; Watanabe, S, 2009) |
| " Next, intestinal inflammation was induced by subcutaneous injections of indomethacin to rats." | 7.74 | Enzyme-modified cheese exerts inhibitory effects on allergen permeation in rats suffering from indomethacin-induced intestinal inflammation. ( Isobe, N; Oda, M; Suzuki, M; Tanabe, S, 2008) |
| " In the present study, the effect of withaferin A, a steroidal lactone was investigated on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin." | 7.74 | Inhibition of monosodium urate crystal-induced inflammation by withaferin A. ( Chandal, S; Rasool, MK; Sabina, EP, 2008) |
| "Results of this study indicate that tacrolimus has an important anti-inflammatory property, showing not only inhibition of pro-inflammatory mediators release, but also inhibition of activated leukocyte infiltration into the site of inflammation." | 7.74 | Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch. ( de Liz, R; Fröde, TS; Medeiros, YS; Vigil, SV, 2008) |
| "The possibility of inducing peritoneal inflammation in three murine species (gerbils, rats and mice) via the oral administration of indomethacin was investigated with the overall aim of developing an experimental animal model for human peritonitis." | 7.73 | Experimental peritonitis induced by oral administration of indomethacin in Mongolian gerbils. ( Kim, O; Lee, JU, 2006) |
| "We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation." | 7.72 | Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003) |
| " Rats with indomethacin-induced enteritis were orally administered Rb, Mn, and Zn as tracers." | 7.72 | Use of rubidium, manganese, and zinc as tracers to measure intestinal permeability by PIXE analysis: basal study in an experimental enteritis model. ( Imaseki, H; Joshima, H; Nakao, K; Saito, Y; Suzuki, Y; Tamanoi, I, 2004) |
| "Effects of misoprostol, a synthetic prostaglandin E1 (PGE1) analogue, on cyclooxygenase-2 (COX-2) protein level and exudate prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) level were investigated in acute carrageenan-induced air pouch inflammation in rats." | 7.71 | Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats. ( Buluç, M; Gürdal, H; Melli, M, 2002) |
| "The objectives of this study were to evaluate the anti-inflammatory effects and possible drug interactions of butorphanol by using carrageenan-induced paw inflammation in rats." | 7.71 | Butorphanol decreases edema following carrageenan-induced paw inflammation in rats. ( Moreau, JP; Vachon, P, 2002) |
| "This study evaluates the action of celecoxib and rofecoxib, two selective cyclooxygenase-2 (COX-2) inhibitors in two acute models of inflammation, carrageenan (Cg)-induced rat pleurisy, and paw oedema formation." | 7.71 | Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. ( Calixto, JB; Pinheiro, RM, 2002) |
| " The antiinflammatory activity of synthetic cannabinoid nabilone in the rat model of carrageenan-induced acute hindpaw inflammation was compared with that of the endocannabinoid palmitoylethanolamide and the nonsteroidal antiinflammatory drug indomethacin." | 7.71 | Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. ( Colleoni, M; Conti, S; Costa, B; Giagnoni, G; Parolaro, D, 2002) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 7.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| "The effect of single or combined administration of indomethacin and misoprostol on the exudate leukocyte count and thromboxane B2, a stable metabolite of thromboxane A2, and on the leukotriene B4 level, as cyclooxygenase and lipoxygenase metabolites of arachidonic acid, was investigated in acute carrageenan-induced air pouch inflammation in rats." | 7.70 | Effect of combination of misoprostol and indomethacin on eicosanoid production in carrageenan-induced air pouch inflammation in rats. ( Melli, M; Sayar, K, 1999) |
| "We investigated the mechanisms by which caffeic acid phenethyl ester (CAPE), a phenolic antioxidant, inhibited the stimulation of prostaglandin (PG) synthesis in cultured human oral epithelial cells and in an animal model of acute inflammation." | 7.70 | Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. ( Carothers, AM; Dannenberg, AJ; Grunberger, D; Koboldt, C; Masferrer, JL; Mestre, JR; Michaluart, P; Sacks, PG; Subbaramaiah, K; Tanabe, T; Zweifel, BS, 1999) |
| " In the present study, therefore, we used the non-steroidal anti-inflammatory drugs indomethacin and sodium salicylate in carrageenan-induced rat paw inflammation, in order to compare their anti-inflammatory action (determined as inhibition of edema) with their effects on the concentration of NGF in inflamed tissue." | 7.70 | Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw. ( Amann, R; Schuligoi, R, 2000) |
| "We implanted indomethacin-coated intraocular lenses (IOLs) in rabbit eyes to ascertain how the sustained release of the drug affects postoperative inflammation and posterior capsule opacification (PCO)." | 7.69 | Effect of indomethacin-coated posterior chamber intraocular lenses on postoperative inflammation and posterior capsule opacification. ( Mizumoto, Y; Nishi, K; Nishi, O; Yamada, Y, 1995) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 7.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| " To investigate the role of inflammation in this response we measured O3 effects in B6 mice pretreated with indomethacin (5 mg/kg), colchicine (3 mg/kg), or cyclophosphamide (30 mg/kg x 7 days)." | 7.69 | Ozone-induced decrease of mouse tracheal potential is not secondary to cellular inflammation. ( Croxton, TL; Kleeberger, SR; Takahashi, M, 1995) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 7.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "Morphine-, methamphetamine- and cocaine-induced place preferences under inflammation produced by unilateral injections of 2." | 7.69 | Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine. ( Kishimoto, Y; Misawa, M; Suzuki, T, 1996) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 7.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| "In BALB/cAnPt (BALB/c) mice, the intraperitoneal injection of pristane induces the formation of chronic oil granulomatous tissue and a high incidence of plasmacytomas (PCT)." | 7.68 | Pristane induces an indomethacin inhibitable inflammatory influx of CD4+ T cells and IFN-gamma production in plasmacytoma-susceptible BALB/cAnPt mice. ( Degrassi, A; McDonald, AH, 1993) |
| "The role of histamine in neutrophil infiltration and vascular permeability response in carrageenin air pouch inflammation in rats was examined." | 7.68 | Downward regulation of neutrophil infiltration by endogenous histamine without affecting vascular permeability responses in air-pouch-type carrageenin inflammation in rats. ( Hirasawa, N; Mue, S; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1991) |
| "The involvement of histamine, the cyclooxygenase system and the kallikrein-kinin system in the generation of the Sephadex inflammation was investigated by in vivo-blocking of these systems." | 7.67 | The involvement of histamine, the cyclooxygenase system and the kallikrein-kinin system in acute inflammation generation, demonstrated with the Sephadex model in rats. ( Egger, G; Macheiner, U, 1987) |
| "The mechanism of the anti-inflammatory effect of proglumetacin maleate, a novel indomethacin derivative, was examined in vivo in an allergic air pouch inflammation model in rats." | 7.67 | Effects of proglumetacin maleate and its major metabolites on allergic air pouch inflammation in rats. ( Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y, 1987) |
| " In vivo, ebselen is a weak oral inhibitor of carrageenan paw oedema and adjuvant arthritis in the rat, differentiating it from classical NSAIDs such as indomethacin and diclofenac." | 7.67 | Ebselen: a new approach to the inhibition of peroxide-dependent inflammation. ( Kuhl, P; Leyck, S; Parnham, MJ; Schalkwijk, J; van den Berg, WB, 1987) |
| "The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated." | 7.67 | Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986) |
| "The addition of indomethacin to concanavalin A (Con A)-induced cultures of human peripheral blood leukocytes (PBL) caused an increase in interferon response, regardless of whether the PBLs were derived from multiple sclerosis (MS) patients or from control donors." | 7.67 | Influence of prostaglandin E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple sclerosis patients and healthy donors. ( Billiau, A; Carton, H; Deckmyn, H; Vervliet, G, 1985) |
| " Aspirin also reduced the levels of PGE2 and TXB2 in the exudate but did not consistently affect PMN influx, thereby confirming that inhibition of cyclo-oxygenase does not reduce cell migration in inflammation." | 7.66 | The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation. ( Moncada, S; Salmon, JA; Simmons, PM, 1983) |
| "The effect of ethanol on the anti-inflammatory actions of indomethacin was studied using carrageenan-induced edema in the paw of the rat as the test for acute inflammation." | 7.66 | Indomethacin-ethanol interactions on acute inflammation. ( Greizerstein, HB, 1983) |
| "The effect of indomethacin and dexamethasone on an allergic inflammation in rats, a novel model of allergic inflammation of an air pouch type, was examined." | 7.66 | A possible role of arachidonate metabolism in allergic air pouch inflammation in rats. Anti-inflammatory effect of indomethacin and dexamethasone and the level of prostaglandin E2 in the exudate. ( Kanaoka, K; Levine, L; Ohuchi, K; Tsurufuji, S; Yoshino, S, 1982) |
| "Twenty-three patients with rheumatoid arthritis and 9 patients with other forms of rheumatic diseases were treated for 20 days with 420 mg glucametacin per day, given as three 140 mg capsules." | 7.66 | Further studies on glucametacin in rheumatoid arthritis and in other chronic types of rheumatism. ( Capelli, L; Chianese, V; Giordano, M; La Montagna, G, 1981) |
| "The influence of the free radical scavenger 2,4-tetra-O-methyl-furfurylidene-sorbitol (MSF) on the carrageenan-induced hind-paw inflammation in rats as well as its influence on the anti-inflammatory and toxic activities of indomethacin is evaluated in comparison with thiola, thioctic acid, silymarin, reduced glutathione and propylgallate." | 7.66 | Influence of 2,4-tetra-O-methyl-furfurylidene-sorbitol (MSF) on carrageenan-induced inflammation and anti-inflammatory and toxic effects of indomethacin in rats. ( Baggio, G; Poggioli, R; Zanoli, P, 1982) |
| "A nonlymphokine mediator of hyperemia has been shown to be secreted by both rabbit peritoneal exudate cells stimulated with 5% glycogen and by concanavalin A treated cells from afferent lymph of sheep." | 7.66 | Secretion of a hyperemia-inducing moiety by mitogen or glycogen stimulated mononuclear inflammatory cells of sheep and rabbit. ( Hay, JB; Vadas, P, 1980) |
| "A model is described of acute inflammation in the pleural cavity of rats using calcium pyrophosphate as the irritant." | 7.65 | Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation. ( Capasso, F; Deporter, DA; Dunn, CJ; Giroud, JP; Willoughby, DA; Yamamoto, S, 1975) |
| "The topical effects of N0164 (a phenyl phosphonate derivative which is a partially selective antagonist of prostagladin E2), indomethacin and triamcinolone acetonide have been shown to reduce the erythema and ear weight gain from inflammation induced by experimental contact allergic eczema." | 7.65 | Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis. ( Lowe, NJ; Stoughton, RB; Virgadamo, F, 1977) |
| "Indomethacin treatment before lens extraction and vitrectomy-lensectomy reduces postoperative inflammation as measured by protein determination of the ocular fluid." | 7.65 | Indomethacin inhibition of prostaglandin-mediated inflammation following intraocular surgery. ( Huang, K; Janevicius, R; McGetrick, J; Peyman, GA, 1977) |
| "Indomethacin was found non-inferior to ketorolac for comparison of aqueous flare at postoperative Days 1 and 7 (Day 1: 95% CI: -2." | 6.78 | Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. ( Allaire, CM; Kodjikian, L; Kruse, FE; Weber, M; Zagorski, Z, 2013) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s." | 6.50 | Role of indomethacin in acute pain and inflammation management: a review of the literature. ( Nalamachu, S; Wortmann, R, 2014) |
| "Lafutidine (LAF) is a novel histamine H2 receptor antagonist with a mucosal protective action." | 5.91 | Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota. ( Chen, J; Chen, X; Guo, J; Liang, H; Liu, Q; Lou, C; Luo, Y; Song, C; Sun, S; Wang, B; Xu, X; Zhao, J; Zhong, W; Zhu, L, 2023) |
| "Alzheimer's disease is a progressive neurodegenerative disease, and its incidence is expected to increase as the global population ages." | 5.62 | Design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents. ( Huang, W; Huang, Y; Ma, L; Wang, R; Yang, G, 2021) |
| "Acute lung injury was efficiently treated by inhibiting the cascade of inflammation, and reducing the inflammatory response in the lung." | 5.62 | Design, synthesis and structure-activity relationship studies of 4-indole-2-arylaminopyrimidine derivatives as anti-inflammatory agents for acute lung injury. ( Chen, T; Wei, Y; Zhang, X; Zhao, H; Zhu, G, 2021) |
| "Icariin was injected in a dose of 50 mg/kg." | 5.51 | Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways. ( Eid, BG; El-Shitany, NA, 2019) |
| " Therefore, it is of increasing importance to configure new dosing strategies and alleviate the side effects of NSAIDs." | 5.48 | Anti-inflammatory polymersomes of redox-responsive polyprodrug amphiphiles with inflammation-triggered indomethacin release characteristics. ( Deng, Z; Hu, J; Liu, G; Liu, S; Tan, J, 2018) |
| "CAPE-indomethacin hybrid was able to significantly attenuate the clinical grading and the PGE2 aqueous levels only at the highest dose (0." | 5.42 | Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation. ( Bucolo, C; Drago, F; Modica, MN; Pittalà, V; Romano, GL; Romeo, G; Salerno, L; Salomone, S; Siracusa, MA, 2015) |
| "Treatment with indomethacin significantly decreased COX-1 and COX-2 transcript expression." | 5.40 | Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice. ( Boehme, M; Frahm, C; Guenther, M; Jaenisch, N; Liebmann, M; Stahr, A; Witte, OW, 2014) |
| " Incidentally, when NSAID use is combined with exercise there is some evidence that this effect may be exacerbated; however, this hypothesis has not been directly tested in a controlled experiment." | 5.39 | Indomethacin in combination with exercise leads to muscle and brain inflammation in mice. ( Davis, JM; Enos, RT; McClellan, JL; Murphy, EA, 2013) |
| "Pretreatment with candesartan for 10 days reduced significantly the ulcer index induced by indomethacin injection." | 5.38 | Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats. ( Awad, AS; El Morsy, EM; Kamel, R, 2012) |
| "Inflammation was induced by injection of 0." | 5.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| "The indomethacin-induced increase of macroscopic and microscopic scores of intestinal inflammation (both P < 0." | 5.35 | Afferent nerve sensitivity is decreased by an iNOS-dependent mechanism during indomethacin-induced inflammation in the murine jejunum in vitro. ( Hausmann, M; Hu, WC; Karpitschka, M; Kasparek, MS; Kreis, ME; Müller, MH; Pesch, T; Rogler, G; Sibaev, A; Xue, B, 2009) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 5.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| "Chronic inflammation has long been associated with neoplastic progression." | 5.35 | Leukotriene B4 creates a favorable microenvironment for murine melanoma growth. ( Bachi, AL; Carneiro, CR; Correa, M; Jasiulionis, MG; Kim, FJ; Lopes, JD; Nonogaki, S, 2009) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 5.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "We previously demonstrated that a novel hydrophilic gamma-tocopherol (gamma-Toc) derivative, gamma-tocopherol-N,N-dimethylglycinate hydrochloride (gamma-TDMG) converts to gamma-Toc in the mouse skin and has a higher bioavailability than gamma-Toc itself." | 5.33 | Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. ( Karube, Y; Kobayashi, S; Takata, J; Watanabe, T; Yamazaki, A; Yoshida, E, 2006) |
| "Indomethacin is a clinically applied nonsteroidal antiphlogistic, and in previous studies in the rat, it has been found to induce an inflammatory reaction in the small intestine characterized by edema and reddening of the intestinal epithelium, ulceration, and dysregulation in the intestinal-epithelial barrier function." | 5.32 | Effect of N-acetylcysteine on microcirculation of mucosa in rat ileum in a model of intestinal inflammation. ( Ruh, J; Schmidt, E; Vogel, F, 2003) |
| "Inflammation was induced by daily interplantar injection of 100 microl of Freund's complete adjuvant into the left hind paw of the rat." | 5.30 | Effect of somatostatin on beta-endorphin release in rat experimental chronic inflammation. ( Corsi, MM; Ferrero, ME; Fulgenzi, A; Gaja, G; Pravettoni, G; Tiengo, M, 1999) |
| "Indomethacin was more potent than prednisolone against PGE2 (ID50 of< 0." | 5.29 | Differential effects of prednisolone and indomethacin on zymosan-induced inflammation in a modified murine tissue-chamber model. ( Dawson, J; Nguyen, H; Oluyomi, AO; Towbin, H; Vosbeck, K, 1995) |
| "Flurbiprofen was less effective than indomethacin in the immediate hypersensitivity reaction (IHR) model." | 5.27 | In vivo effects of indomethacin and flurbiprofen on the locomotion of neutrophils elicited by immune and non-immune inflammation in the rat. ( Giroud, JP; Hakim, J; Perianin, A; Roch-Arveiller, M, 1984) |
| "1% indomethacin and gentamicin proved to be effective and well tolerated in preventing inflammation after cataract surgery." | 5.08 | [Efficacy and tolerability of a combination of indomethacin and gentamicin for preventing inflammation after cataract surgery]. ( Adenis, JP; Allaire, C; Brasseur, G; Couderc, JL; Dascotte, JC; Hoang-Xuan, T; Renard, G; Rouland, JF; Trinquand, C; Ullern, M, 1996) |
| "1% diclofenac, in the management of post cataract surgery inflammation." | 5.08 | [Double-blind study on 3 parallel groups of 2 formulations of 0.1% indomethacin and 0.1% diclofenac in preventing and controlling inflammation after cataract surgery]. ( Arnaud, B; Trinquand, C, 1997) |
| "Seventy glaucomatous eyes received argon laser trabeculoplasty (ALT) to 180 degrees of the trabecular meshwork." | 5.05 | Nonsteroidal anti-inflammatory agents after argon laser trabeculoplasty. A trial with flurbiprofen and indomethacin. ( Hotchkiss, ML; Pollack, IP; Quigley, HA; Robin, AL, 1984) |
| "Fifty-four hospitalized patients with rheumatoid arthritis participated in a dose-range study comparing benoxaprofen with placebo and in a further study comparing benoxaprofen with indomethacin." | 5.05 | Benoxaprofen--dose-range studies using quantitative thermography. ( Bacon, PA; Davies, J; Ring, FJ, 1980) |
| "In a controlled double blind study the therapeutic efficacy and tolerability of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-3-acetoxy] acetic acid (acemetacin, TV 1322, Rantudil¿) and tolmetin were compared in 40 patients suffering from acute and subacute painful irritant conditions in the spinal area and joints." | 5.05 | [Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)]. ( Handrich, L, 1980) |
| "Preliminary findings are reported from an open study of 300 mg flurbiprofen daily in 24 patients and from 6 out of 30 patients treated so far in a double-blind crossover comparison of 300 mg flurbiprofen daily and 150 mg indomethacin daily in the treatment of rheumatoid arthritis." | 5.04 | Flurbiprofen in rheumatoid arthritis therapy. ( Loizzi, P; Numo, R; Pipitone, V, 1977) |
| "The degree of joint inflammation in 13 patients with rheumatoid arthritis, as measured by clinical indices, was reduced by both sodium salicylate and indomethacin." | 5.03 | Effect of anti-inflammatory drug therapy on clearance of 133-Xe from knee joints of patients with rheumatoid arthritis. ( Boyle, JA; Buchanan, WW; Dick, C; Dick, PH; Downie, WW; Nuki, G; Shenkin, A; Whaley, K, 1969) |
| " To investigate the causative relationship between neuro-inflammation and dyskinesias, we assessed if striatal M1 and M2 microglia numbers correlated with dyskinesia severity and whether the anti-inflammatories, minocycline and indomethacin, reverse these numbers and mitigate against dyskinesia." | 4.31 | The ratio of M1 to M2 microglia in the striatum determines the severity of L-Dopa-induced dyskinesias. ( Egan, T; Kuriakose, A; Rentsch, P; Stayte, S; Vissel, B, 2023) |
| "This experiment aimed to investigate the preventive effect of ethanol extract (RM) from Chinese sumac fruits on indomethacin-induced gastric ulcer in mice and the underlying mechanisms." | 4.12 | Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis. ( Cai, S; Ma, N; Sun, Y; Yi, J; Zhou, L, 2022) |
| "Indomethacin (IND) is topically administered for the treatment of the anterior segment diseases such as conjunctivitis, uveitis, and inflammation prevention for post-cataract surgery, as well as posterior segment diseases as macular edema." | 4.12 | Chitosan/sulfobutylether-β-cyclodextrin based nanoparticles coated with thiolated hyaluronic acid for indomethacin ophthalmic delivery. ( Arduino, I; Cutrignelli, A; Denora, N; Franco, M; Laquintana, V; Lopalco, A; Lopedota, A; Racaniello, GF; Ricci, F; Sigurdsson, HH, 2022) |
| " The related optimal dose and time point of ciprofloxacin or indomethacin in response to macrophage inflammatory response inflammation were determined via macrophage secretion induced by LPS." | 4.12 | The combination of ciprofloxacin and indomethacin suppresses the level of inflammatory cytokines secreted by macrophages in vitro. ( Li, SY; Liu, K; Xia, Y; Yan, J; Yu, J; Zhang, LT, 2022) |
| " The anthocyanidin effects were examined in gastric ulcer mouse models induced by ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia-reperfusion (IR), acetic acid and duodenal ulcer induced by polypharmacy." | 4.02 | Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation. ( Dos Santos, RC; Fagundes, FL; Pereira, QC; Zarricueta, ML, 2021) |
| " This study implies the therapeutic effect of IND and juglone [JUG] against colon carcinogenesis, without gastric ulceration - an adverse side effect of IND." | 4.02 | Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis. ( Devaraj, H; Seetha, A; Sudhandiran, G, 2021) |
| "Paw edema was attenuated following the administration of indomethacin-loaded polymeric micelles." | 4.02 | Indomethacin loaded dextran stearate polymeric micelles improve adjuvant-induced arthritis in rats: design and in vivo evaluation. ( Abdollahi, AR; Firouzian, F; Haddadi, R; Nourian, A, 2021) |
| " Hence, we investigated whether probiotics can control the onset of this severe condition in a murine model of intestinal inflammation induced by the NSAID, indomethacin." | 4.02 | Probiotic lactobacilli as a promising strategy to ameliorate disorders associated with intestinal inflammation induced by a non-steroidal anti-inflammatory drug. ( Balcells, MF; Cazorla, SI; De Paula, JA; Galdeano, CM; Monteros, MJM; Perdigón, G; Weill, R, 2021) |
| "In the present study, milnacipran showed anti-nociceptive and anti-inflammatory effects on carrageenan-induced hyperalgesia and inflammation in a dose-dependent manner." | 3.96 | Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress. ( Haddadi, R; Rashtiani, R, 2020) |
| " In this work, an enzyme-responsive anti-inflammatory prodrug capable of generating indomethacin upon the trigger of inflammation is developed." | 3.96 | An Enzyme-Responsive Prodrug with Inflammation-Triggered Therapeutic Drug Release Characteristics. ( Gong, M; Liao, M; Meng, Q; Shi, R; Xie, W; Xue, J; Ye, J; Zhang, L; Zhang, X, 2020) |
| "The present studies were designed to evaluate inhalatory microparticles carrying indomethacin (IN) for potential local (specific and non-specific bronchial inflammatory asthma responses) and systemic treatments (joint inflammation, rheumatoid arthritis and osteoarthritis pain) by optimizing microparticle properties, characterizing their lung deposition, drug release, evaluating cytotoxicity and also pharmacological effect in vitro." | 3.88 | Carrier free indomethacin microparticles for dry powder inhalation. ( Bucalá, V; Ceschan, NE; Mateos, MV; Ramírez-Rigo, MV; Smyth, HDC, 2018) |
| " lingzhi and its autodigested product (AD-GL) against gut inflammation and endogenous sepsis induced in mice by the oral administration of indomethacin (IND)." | 3.88 | Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes). ( Adachi, Y; Igami, K; Ishibashi, KI; Ishimoto, Y; Ito, H; Miyazaki, T; Ohno, N; Yamanaka, D, 2018) |
| " chamomilla extract (MCE) with two NSAIDs, diclofenac and indomethacin on carrageenan-induced paw inflammation and gastric injury in rats." | 3.85 | Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan-Induced Paw Inflammation in Rats. ( Cariño-Cortés, R; Castañeda-Hernández, G; González-García, MP; Ortiz, MI; Ponce-Monter, HA; Salinas-Caballero, M, 2017) |
| "The neurologic manifestations of neonatal hyperbilirubinemia in the central nervous system (CNS) exhibit high variations in the severity and appearance of motor, auditory and cognitive symptoms, which is suggestive of a still unexplained selective topography of bilirubin-induced damage." | 3.85 | Evaluation of region selective bilirubin-induced brain damage as a basis for a pharmacological treatment. ( Bottin, C; Dal Ben, M; Gazzin, S; Tiribelli, C; Zanconati, F, 2017) |
| "It has been demonstrated that the zebrafish model of pentylenetetrazole (PTZ)-evoked seizures and the well-established rodent models of epilepsy are similar pertaining to behavior, electrographic features, and c-fos expression." | 3.83 | Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. ( Barbalho, PG; Lopes-Cendes, I; Maurer-Morelli, CV, 2016) |
| " In this study, a series of novel thiazolo[3,2-b]-1,2,4-triazole-6(5H)-one derivatives bearing naproxen was synthesized and evaluated for their in vivo analgesic and anti-inflammatory properties in acute experimental pain and inflammation models." | 3.81 | Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies. ( Ertan, M; Kazkayasi, I; Okay, G; Ozadali-Sari, K; Sarigol, D; Somuncuoglu, EI; Tel, BC; Tozkoparan, B; Unsal-Tan, O; Uzgoren-Baran, A, 2015) |
| " The results showed that amygdalin and cinnamic acid inhibit serine phosphorylation of IRS-1 through targeting JNK serine kinase and enhance insulin sensitivity." | 3.81 | Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-α-induced insulin resistance. ( Kim, MJ; Rangasamy, S; Shim, Y; Song, JM, 2015) |
| "Cu-Indo gel at lower doses was superior to or at least as effective as its parent substance, indomethacin, in most of the studied parameters of inflammation." | 3.81 | Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015) |
| " Xylene-induced ear edema, carrageenan-induced paw edema and acetic acid-induced vascular permeability test were used to investigate the anti-inflammatory activities of GL in mice." | 3.81 | Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice. ( Li, YX; Ma, L; Niu, Y; Niu, YT; Shi, GJ; Sun, T; Wang, HL; Wu, J; Yu, JQ; Zheng, J, 2015) |
| "An autofeedback complex polymeric platform was used in the design of an intelligent intraocular implant-the I(3)-using stimuli-responsive polymers, producing a smart release system capable of delivering therapeutic levels of an anti-inflammatory agent (indomethacin) and antibiotic (ciprofloxacin) for posterior segment disorders of the eye in response to inflammation." | 3.80 | In vitro, in vivo, and in silico evaluation of the bioresponsive behavior of an intelligent intraocular implant. ( Carmichael, T; Choonara, YE; du Toit, LC; Govender, T; Kumar, P; Pillay, V, 2014) |
| " Inflammation was studied when evoked, either by PDT using a trisulfonated porphyrazine photosensitizer, or lipopolysaccharide (LPS), and inhibited using indomethacin." | 3.80 | Deciphering PDT-induced inflammatory responses using real-time FDG-PET in a mouse tumour model. ( Cauchon, N; Hasséssian, HM; Lecomte, R; Turcotte, E; van Lier, JE, 2014) |
| " Analog 19 was a more potent anti-inflammatory agent than the reference compound indomethacin and of comparable cytocompatibility to 8-MOP whereas analog 24 was a weaker inhibitor of inflammation than indomethacin and significantly more cytotoxic than 8-MOP." | 3.79 | Syntheses and evaluation of the antioxidant activity of novel methoxypsoralen derivatives. ( Athanassopoulos, CM; Avgoustakis, K; Bariamis, SE; Hadjipavlou-Litina, D; Kontogiorgis, C; Marin, M; Papaioannou, D; Romeo, G; Sindona, G; Tsimali, Z, 2013) |
| " Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test." | 3.79 | Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines. ( Borghi, SM; Carvalho, TT; Casagrande, R; Hohmann, MS; Pinge-Filho, P; Staurengo-Ferrari, L; Verri, WA, 2013) |
| " The anti-inflammatory activity of 1a-h was investigated by acute carrageenan-induced paw edema in mice using the reference drug indomethacin." | 3.79 | Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties. ( Al-Tabakha, MM; Caproiu, MT; Fahelelbom, KM; Limban, C; Missir, AV; Sadek, B, 2013) |
| " The present study aimed to assess the role of cysteinyl leukotriene receptor antagonist on peripheral inflammation and whether montelukast treatment enhances the anti-inflammatory effect of indomethacin." | 3.79 | Potentiation of indomethacin-induced anti-inflammatory response by montelukast in formalin-induced inflammation in rats. ( Behmanesh, MA; Ghorbanzadeh, B; Hemmati, AA, 2013) |
| "To evaluate the efficacy of boswellic acid against monosodium urate crystal-induced inflammation in mice." | 3.78 | Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice. ( Indu, H; Rasool, M; Sabina, EP, 2012) |
| " The oral administration of the Chantaleela recipe reduced ulcer formation in acute gastric ulcer models (EtOH/HCl-, indomethacin-, and stress-induced gastric lesions)." | 3.78 | Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe. ( Jaijoy, K; Khonsung, P; Nanna, U; Piyabhan, P; Sireeratawong, S; Soonthornchareonnon, N, 2012) |
| "The pharmacokinetics of ϵ-acetamidocaproic acid (AACA) were evaluated after the intravenous and oral administration of an antiulcer agent, zinc acexamate (ZAC) at a dose of 20 mg kg⁻¹ (ion pairing between zinc and AACA) in rats with indomethacin-induced acute gastric ulcer (IAGU) or indomethacin-induced small bowel inflammation (ISBI)." | 3.78 | ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation. ( Choi, YH; Kim, YG; Lee, BK; Lee, MG; Lee, U; Oh, E, 2012) |
| " Systemic injection of an NK1 receptor antagonist, WIN 51708, significantly inhibited the joint swelling, but not the mechanical allodynia, on day 7 in CAIA mice." | 3.78 | Involvement of tachykinins and NK1 receptor in the joint inflammation with collagen type II-specific monoclonal antibody-induced arthritis in mice. ( Ito, H; Makino, A; Sakai, A; Suzuki, H, 2012) |
| "We investigated the effect of argirein on acute inflammation edema and examined that aquaporin 4 (AQP4), p66Shc and activating transcription factor (ATF-6) might be involved in carrageenan-induced rat paw inflammation and be reversed by argirein, rhein and indometacin, but not L-arginine." | 3.78 | Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| "This study reports a pharmacological evaluation of anti-inflammatory and anti-ulcer activities of carvacrol, a phenolic monoterpene constituent of essential oils produced by oregano and other several aromatic plants and spices, in experimental models of edema induced by different phlogistic agents and gastric lesions induced by acetic acid." | 3.78 | Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano. ( Arcanjo, DD; Guimarães, AG; Machado, FD; Oliveira, FA; Oliveira, RC; Quintans-Júnior, LJ; Silva, ER; Silva, FV; Sousa-Neto, BP, 2012) |
| " In this paper the topical anti-inflammatory activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using the Croton oil ear test in mice as a model of acute inflammation." | 3.77 | Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives. ( Curini, M; Epifano, F; Genovese, S; Marcotullio, MC; Sosa, S; Tubaro, A, 2011) |
| "Tamoxifen was seen to suppress carrageenan-induced inflammation significantly." | 3.77 | Role of adrenal gland hormones in the anti-inflammatory effect mechanism of tamoxifen, a partial antagonist for oestrogen receptors, and relation with COX levels. ( Alp, HH; Borekci, B; Cadirci, E; Karaca, M; Kumbasar, S; Kumtepe, Y; Salman, S; Suleyman, H; Yildirim, K, 2011) |
| " With the adjuvant arthritis model, the prophylactic efficacy profile of ABC294640 was similar to indomethacin." | 3.77 | Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. ( Donahue, H; Fitzpatrick, LR; Frauenhoffer, EE; French, KJ; Green, C; Maines, LW; Mosher, TJ; Paul, E; Smith, CD; Upson, JJ; Zhuang, Y, 2011) |
| " While the analgesic activity was examined against thermally and chemically induced nociceptive pain in mice, using the acetic acid and hot-plate test methods." | 3.77 | Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha. ( Duan, JA; Hua, YQ; Qian, DW; Su, S; Tang, YP; Wang, T; Yu, L; Zhou, W, 2011) |
| "Anti-inflammatory and antioxidative potential of hesperidin and naringin was carried out considering the rat air pouch model of inflammation." | 3.77 | Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. ( Jain, M; Parmar, HS, 2011) |
| "Dexamethasone and indomethacin each reduced pain behavior, synovial inflammation, and synovial angiogenesis 35 days after meniscal transection." | 3.77 | Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis. ( Ashraf, S; Mapp, PI; Walsh, DA, 2011) |
| "Salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their complexes [Zn(LASSBio-466)H(2)O](2) (1) and [Zn(HLASSBio-1064)Cl](2) (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation." | 3.77 | Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes. ( Alexandre-Moreira, MS; Alves, MA; Barreiro, EJ; Beraldo, H; Castellano, EE; Júnior, WB; Lima, LM; Parrilha, GL; Perez-Rebolledo, A; Piro, OE, 2011) |
| " Acitretin and its analogs 5-7, 10, 11 and 15 inhibited lipid peroxidation more strongly than trolox whereas acitretin and analog 4 were in vivo more potent anti-inflammatory agents on rat paw oedema induced by Carrageenan than indomethacin." | 3.76 | Syntheses and evaluation of the antioxidant activity of acitretin analogs with amide bond(s) in the polyene spacer. ( Hadjipavlou-Litina, D; Krokidis, M; Magoulas, GE; Papaioannou, D, 2010) |
| " We also evaluated whether an anti-inflammatory drug could prevent or diminish METH-induced neuroinflammation, and we concluded that indomethacin (10 mg/kg; i." | 3.76 | Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin. ( Baptista, S; Borges, F; Gonçalves, J; Malva, JO; Martins, T; Milhazes, N; Ribeiro, CF; Silva, AP, 2010) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of acute gout and inflammation." | 3.76 | Acemetacin antinociceptive mechanism is not related to NO or K+ channel pathways. ( Castañeda-Hernández, G; Chávez-Piña, AE; Gil-Flores, M; Ortiz, MI, 2010) |
| "To test the hypothesis that intrauterine inflammation increases prostaglandin production and may be a risk factor for persistent ductus arteriosus after therapy with indomethacin, a nonselective cyclooxygenase inhibitor." | 3.76 | Intrauterine inflammation as a risk factor for persistent ductus arteriosus patency after cyclooxygenase inhibition in extremely low birth weight infants. ( Choi, CW; Choi, JH; Kim, BI; Kim, EK; Kim, ES; Kim, HS; Moon, KC; Park, JS, 2010) |
| "Administration of indomethacin (10mg/kg), paracetamol (150 mg/kg) and/or different doses of earthworm extract (EE) (50, 100 and 200mg/kg) reduced and restored to normal conditions in a dose-dependent manner of histamine and turpentine induced inflammation, and Brewer's yeast induced pyretic in rats." | 3.75 | Anti-inflammatory and anti-pyretic activities of earthworm extract-Lampito mauritii (Kinberg). ( Balamurugan, M; Cooper, EL; Parthasarathi, K; Ranganathan, LS, 2009) |
| "We conclude that ATL-313 does not inhibit the mucosal damaging effect of indomethacin, but it does block secondary injury due to stomach inflammation." | 3.75 | Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats. ( Jin, M; Koizumi, S; Linden, J; Odashima, M; Ohnishi, H; Otaka, M; Watanabe, S, 2009) |
| " Groups (N = 6-8) were submitted to right or left paw edema (PE) with carrageenan (100 microg) or Dextran (200 microg), hemorrhagic cystitis with ifosfamide (200 mg/kg, ip) or gastric injury (GI) with indomethacin (20 mg/kg, vo)." | 3.75 | Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats. ( Gomes, AS; Loiola, RT; Ribeiro, RA; Rocha, EL; Simão, AF; Souza Filho, MV; Souza, MH, 2009) |
| " The most potent compound, namely TRX derivative 3, was studied for its anti-inflammatory activity in vivo on rat paw edema induced by carrageenan, and was found to be of almost identical activity to indomethacin." | 3.75 | Trioxsalen derivatives with lipoxygenase inhibitory activity. ( Athanassopoulos, CM; E Bariamis, S; Hadjipavlou-Litina, D; Militsopoulou, M; Papaioannou, D, 2009) |
| " Next, intestinal inflammation was induced by subcutaneous injections of indomethacin to rats." | 3.74 | Enzyme-modified cheese exerts inhibitory effects on allergen permeation in rats suffering from indomethacin-induced intestinal inflammation. ( Isobe, N; Oda, M; Suzuki, M; Tanabe, S, 2008) |
| "Inflammation was induced in mice, using either turpentine or indomethacin." | 3.74 | How reliable an indicator of inflammation is myeloperoxidase activity? ( Faith, M; Jacob, M; Pulimood, AB; Sukumaran, A, 2008) |
| "Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin are widely used in the treatment of inflammation, fever and pain." | 3.74 | Beneficial effects of vegetable oils (corn, olive and sunflower oils) and alpha-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats. ( Atalay, F; Aygun, H; Cadirci, E; Cakir, A; Halici, M; Halici, Z; Odabasoglu, F; Suleyman, H, 2008) |
| " In the present study, the effect of withaferin A, a steroidal lactone was investigated on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin." | 3.74 | Inhibition of monosodium urate crystal-induced inflammation by withaferin A. ( Chandal, S; Rasool, MK; Sabina, EP, 2008) |
| " Although indomethacin, one of cyclooxygenase inhibitors, is known to suppress UV-induced acute skin inflammation, it remains uncertain whether endogenous PGE(2) is responsible for UV-induced skin inflammation, and which subtype of PGE(2) receptors mediates this process." | 3.74 | Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors. ( Honda, T; Kabashima, K; Miyachi, Y; Nagamachi, M; Narumiya, S; Nishigori, C; Tokura, Y, 2007) |
| " In an air pouch-type LPS-induced inflammation model in mice 30 mg/kg amiloride and 10 mg/kg EIPA as well as the COX inhibitor indomethacin (10 mg/kg), significantly reduced the level of PGE2 in the pouch fluid at 8 h and the vascular permeability from 4 to 8 h." | 3.74 | Inhibition of lipopolysaccharide-induced prostaglandin E2 production and inflammation by the Na+/H+ exchanger inhibitors. ( Ban, HS; Hirasawa, N; Kamachi, F; Ohuchi, K, 2007) |
| "Pain threshold increased after treatment, and was significantly increased in the loxoprofen-Na group compared with the control group (p < 0." | 3.74 | Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. ( Kikuchi, S; Konno, S; Sekiguchi, M; Shirasaka, M, 2008) |
| "The results indicate that both Zafirlukast and Zileuton reduced the reported DCS symptoms, pulmonary edema, pleural and bronchoalveolar lavage protein levels, white blood cell counts in the pleural and bronchoalveolar lavage, and leukotriene levels in the bronchoalveolar lavage vs." | 3.74 | Pharmacological intervention to the inflammatory response from decompression sickness in rats. ( Butler, BD; Little, T, 2008) |
| "Results of this study indicate that tacrolimus has an important anti-inflammatory property, showing not only inhibition of pro-inflammatory mediators release, but also inhibition of activated leukocyte infiltration into the site of inflammation." | 3.74 | Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch. ( de Liz, R; Fröde, TS; Medeiros, YS; Vigil, SV, 2008) |
| " It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects." | 3.74 | Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice. ( Itabashi, T; Kawai, K; Takido, M; Yasukawa, K, 2008) |
| "The present study was aimed to evaluate the effect of licofelone, a dual inhibitor of cycloxygenase1/2-5-lipoxygenase against indomethacin-induced gastric damage in rats and mice in order to assess the role of leukotrienes if any, in non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastrointestinal inflammation." | 3.73 | Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation. ( Kulkarni, SK; Patil, CS; Singh, VP, 2005) |
| "Although anti-TNF treatment suppresses inflammation and restores gut barrier function in patients with CD, it does not antagonize the barrier hyperresponsiveness to indomethacin." | 3.73 | Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent. ( Bulteel, V; Noman, M; Rutgeerts, P; Suenaert, P; Van Assche, G; Vermeire, S, 2005) |
| " We evaluated the relationship between TNF-alpha and iNOS expression in indomethacin-induced jejunoileitis in male Sprague-Dawley rats." | 3.73 | Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression. ( Finocchiaro, S; Levine, RA; Nandi, J; Ong, G; Saud, B, 2005) |
| "The possibility of inducing peritoneal inflammation in three murine species (gerbils, rats and mice) via the oral administration of indomethacin was investigated with the overall aim of developing an experimental animal model for human peritonitis." | 3.73 | Experimental peritonitis induced by oral administration of indomethacin in Mongolian gerbils. ( Kim, O; Lee, JU, 2006) |
| "Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP(2)) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases." | 3.73 | Discovery of potent CRTh2 (DP2) receptor antagonists. ( Arrowsmith, EC; Beech, C; Bell, FM; Birkinshaw, TN; Bonnert, RV; Carrillo, JJ; Dougall, IG; Hill, S; Paine, SW; Patel, A; Phillips, TT; Reakes, S; Salter, S; Sanganee, H; Schmidt, J; Teague, SJ; Weaver, R, 2006) |
| "In the present study, we evaluated the consequences of prostaglandin E(2) (PGE(2)) or indomethacin injection into the spinal cord, on a model of peripheral inflammatory edema." | 3.72 | A spinal mechanism for the peripheral anti-inflammatory action of indomethacin. ( Daher, JB; Tonussi, CR, 2003) |
| "Endothelin-1 (ET-1) exerts many biological effects in airways, including bronchoconstriction, airway mucus secretion, cell proliferation, and inflammation." | 3.72 | Effects of endothelin-1 on epithelial ion transport in human airways. ( Blouquit, S; Chinet, T; D'herbomez, M; Lombet, A; Matran, R; Naline, E; Sari, A, 2003) |
| "In our study, the effects of the compound 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride (C1) and also an anti-inflammatory drug, indomethacin, tested by carrageenan-induced paw edema and cotton pellet granuloma tests, for their effects on acute and chronic phases of inflammation, respectively." | 3.72 | Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride. ( Asoglu, M; Gul, HI; Suleyman, H, 2003) |
| "The effect of valeryl salicylate (VS), an inhibitor of cyclooxygenase-1 (COX-1), was evaluated in arachidonic acid or croton oil-induced ear oedema and carrageenan-induced paw oedema in mice." | 3.72 | Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice. ( Brum-Fernandes, AJ; Peters, RR; Ribeiro-do-Valle, RM; Siqueira-Junior, JM, 2003) |
| "We previously discovered that a 4-wk course of indomethacin delivered to rats with acetic acid ulcers resulted in production of "unhealed gastric ulcers" that persisted for up to 12 wks after treatment cessation." | 3.72 | Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats. ( Amagase, K; Okabe, S; Tsukimi, Y; Yokota, M, 2003) |
| "The anti-inflammatory activity of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), was studied on the carrageenan-induced paw inflammation in the rat." | 3.72 | Studies on the anti-inflammatory effect of fluoxetine in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR, 2004) |
| " Four compounds were proved to be as active as indomethacin in animal models of inflammation." | 3.72 | Tetrazolo[1,5-a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents. ( Aboulmagd, E; Bekhit, AA; El-Sayed, OA; Park, JY, 2004) |
| " Rats with indomethacin-induced enteritis were orally administered Rb, Mn, and Zn as tracers." | 3.72 | Use of rubidium, manganese, and zinc as tracers to measure intestinal permeability by PIXE analysis: basal study in an experimental enteritis model. ( Imaseki, H; Joshima, H; Nakao, K; Saito, Y; Suzuki, Y; Tamanoi, I, 2004) |
| "Rats were injected with LPS to induce uveitis and divided into three groups: treated with LPS only, LPS + dexamethasone and LPS + indomethacin, respectively." | 3.72 | The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats. ( Bajor, T; Farkas, A; Hrabák, A; Szabó, A; Vámos, R, 2004) |
| "Effects of misoprostol, a synthetic prostaglandin E1 (PGE1) analogue, on cyclooxygenase-2 (COX-2) protein level and exudate prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) level were investigated in acute carrageenan-induced air pouch inflammation in rats." | 3.71 | Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats. ( Buluç, M; Gürdal, H; Melli, M, 2002) |
| "The objectives of this study were to evaluate the anti-inflammatory effects and possible drug interactions of butorphanol by using carrageenan-induced paw inflammation in rats." | 3.71 | Butorphanol decreases edema following carrageenan-induced paw inflammation in rats. ( Moreau, JP; Vachon, P, 2002) |
| "This study evaluates the action of celecoxib and rofecoxib, two selective cyclooxygenase-2 (COX-2) inhibitors in two acute models of inflammation, carrageenan (Cg)-induced rat pleurisy, and paw oedema formation." | 3.71 | Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. ( Calixto, JB; Pinheiro, RM, 2002) |
| " Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited DMBA-induced inflammation and local immunosuppression." | 3.71 | Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2. ( Horio, T; Kuwamoto, K; Miyauchi-Hashimoto, H; Tanaka, K; Urade, Y, 2001) |
| " The antiinflammatory activity of synthetic cannabinoid nabilone in the rat model of carrageenan-induced acute hindpaw inflammation was compared with that of the endocannabinoid palmitoylethanolamide and the nonsteroidal antiinflammatory drug indomethacin." | 3.71 | Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. ( Colleoni, M; Conti, S; Costa, B; Giagnoni, G; Parolaro, D, 2002) |
| " We compared the effects of nimesulide, a preferential COX-2 inhibitor, with those of indomethacin, acetylsalicylic acid (ASA), and dexamethasone in a 24-h model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in the rat." | 3.71 | Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. ( Kankuri, E; Korpela, R; Moilanen, E; Paakkari, I; Vaali, K; Vapaatalo, H, 2001) |
| " The effects of C-1 on the acute phase of inflammation were studied in formaldehyde-induced edema." | 3.71 | An investigation of the antiinflammatory effects of an extract from Cladonia rangiformis HOFFM. ( Aslan, A; Gepdiremen, A; Göçer, F; Güvenalp, Z; Süleyman, H; Yildirim, D, 2002) |
| " The objective of this study was to assess the effect of lactulose (Lac) and neomycin (Neo), both of which are used clinically for changing or reducing intestinal flora, on leukocyte-endothelial cell interaction in an indomethacin (Indo)-induced long-lasting ileitis in Sprague-Dawley rats." | 3.70 | Lactulose and neomycin attenuate leukocyte-endothelial cell adhesion in an animal model of inflammatory bowel disease. ( Arndt, H; Palitzsch, KD; Schölmerich, J, 1998) |
| " Chronic intestinal inflammation was induced in rats with indomethacin (7." | 3.70 | Antiinflammatory actions of cat's claw: the role of NF-kappaB. ( Charbonnet, RM; Clark, DA; Liu, X; Mannick, EE; Miller, MJ; Sadowska-Krowicka, H; Sandoval-Chacón, M; Thompson, JH; Zhang, XJ, 1998) |
| "The effect of single or combined administration of indomethacin and misoprostol on the exudate leukocyte count and thromboxane B2, a stable metabolite of thromboxane A2, and on the leukotriene B4 level, as cyclooxygenase and lipoxygenase metabolites of arachidonic acid, was investigated in acute carrageenan-induced air pouch inflammation in rats." | 3.70 | Effect of combination of misoprostol and indomethacin on eicosanoid production in carrageenan-induced air pouch inflammation in rats. ( Melli, M; Sayar, K, 1999) |
| "We investigated the mechanisms by which caffeic acid phenethyl ester (CAPE), a phenolic antioxidant, inhibited the stimulation of prostaglandin (PG) synthesis in cultured human oral epithelial cells and in an animal model of acute inflammation." | 3.70 | Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. ( Carothers, AM; Dannenberg, AJ; Grunberger, D; Koboldt, C; Masferrer, JL; Mestre, JR; Michaluart, P; Sacks, PG; Subbaramaiah, K; Tanabe, T; Zweifel, BS, 1999) |
| " In contrast, levels of prostaglandin D2, and 15deoxy delta(12-14)prostaglandin J2 were high at 2 hours, decreased as inflammation increased, but were increased again at 48 hours." | 3.70 | Inducible cyclooxygenase may have anti-inflammatory properties. ( Chivers, J; Colville-Nash, PR; Gilroy, DW; Paul-Clark, MJ; Willis, D; Willoughby, DA, 1999) |
| " In the present study, therefore, we used the non-steroidal anti-inflammatory drugs indomethacin and sodium salicylate in carrageenan-induced rat paw inflammation, in order to compare their anti-inflammatory action (determined as inhibition of edema) with their effects on the concentration of NGF in inflamed tissue." | 3.70 | Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw. ( Amann, R; Schuligoi, R, 2000) |
| "Nimesulide significantly decreased the extent of colitis induced by acetic acid." | 3.70 | Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats. ( Cohen, P; Karmeli, F; Rachmilewitz, D, 2000) |
| "We implanted indomethacin-coated intraocular lenses (IOLs) in rabbit eyes to ascertain how the sustained release of the drug affects postoperative inflammation and posterior capsule opacification (PCO)." | 3.69 | Effect of indomethacin-coated posterior chamber intraocular lenses on postoperative inflammation and posterior capsule opacification. ( Mizumoto, Y; Nishi, K; Nishi, O; Yamada, Y, 1995) |
| " In this study, in order to evaluate the cough and inflammatory reaction, we measured the number of citric acid-induced coughs and the intradermal inflammation with ovalbumin in guinea pigs consecutively treated with ACE inhibitors (lisinopril, enalaprilat and imidapril) for 3 days." | 3.69 | Toxicodynamic analysis of cough and inflammatory reactions by angiotensin-converting enzyme inhibitors in guinea pig. ( Iga, T; Ito, K; Kamei, J; Misawa, M; Sawada, Y, 1995) |
| "The effects of indomethacin on the production of cytokines at inflammatory sites were investigated in the monosodium urate (MSU) pleurisy model characterized by both cellular influx and edema." | 3.69 | Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats. ( Aihara, S; Murakami, N; Namba, K; Naruse, T; Tomita, T, 1995) |
| "This study evaluated the 'evoked' expression of Krox-24 protein in the lumbar spinal cord after peripheral carrageenan-induced inflammation and its modification by preadministration of indomethacin, a non-steroidal anti-inflammatory drug, in freely moving rats." | 3.69 | Indomethacin reduces both Krox-24 expression in the rat lumbar spinal cord and inflammatory signs following intraplantar carrageenan. ( Besson, JM; Buritova, J; Honoré, P, 1995) |
| " To investigate the role of inflammation in this response we measured O3 effects in B6 mice pretreated with indomethacin (5 mg/kg), colchicine (3 mg/kg), or cyclophosphamide (30 mg/kg x 7 days)." | 3.69 | Ozone-induced decrease of mouse tracheal potential is not secondary to cellular inflammation. ( Croxton, TL; Kleeberger, SR; Takahashi, M, 1995) |
| "Indomethacin, a typical cyclo-oxygenase inhibitor, acts as an analgesic by preventing the hyperalgesia induced by prostaglandins during inflammation." | 3.69 | Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. ( Ferreira, SH; Tonussi, CR, 1994) |
| " Since the non-steroidal anti-inflammatory agents, indomethacin and aspirin, were inactive, cyclooxygenase products are not involved in the anaphylactic reaction in boosted or unboosted mice." | 3.69 | Involvement of leukotrienes in allergic inflammation in mice. ( Cordeiro, RS; Vargaftig, BB; Zuany-Amorim, C, 1994) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 3.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| " Since exposure to ozone also caused neuronal M2 receptors to become dependent upon cyclooxygenase the effects of viral infection are likely to be due to inflammation." | 3.69 | Viral infection induces dependence of neuronal M2 muscarinic receptors on cyclooxygenase in guinea pig lung. ( Fryer, AD; Jacoby, DB; Kahn, RM; Okanlami, OA, 1996) |
| "Morphine-, methamphetamine- and cocaine-induced place preferences under inflammation produced by unilateral injections of 2." | 3.69 | Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine. ( Kishimoto, Y; Misawa, M; Suzuki, T, 1996) |
| " These models of acute and chronic inflammation, and the antimitotic model permitted us to evaluate the anti-inflammatory and antimitotic effects of sulindac, ibuprofen, naproxen and glucametacin." | 3.69 | Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque. ( Akatsu, T; Consolaro, A; Guimarães, SA; Tago, EM, 1996) |
| "To investigate the possible mechanism of the therapeutic action of propolis, we studied: (a) the effect of propolis, its components, caffeic acid phenethyl ester (CAPE), caffeic acid (CA), quercetin and naringenin, as well as the synthetic compounds indomethacin (IM) and nordihydroguaiaretic acid (NDGA), and a novel lipoxygenase inhibitor N,N'-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)isourea (DCHCU) on eicosanoid production by mouse peritoneal macrophages in vitro; (b) the effect of IM, NDGA, CA, CAPE, DCHCU and propolis on eicosanoid production during acute inflammation in vivo; and (c) the ex vivo and in vivo effect of dietary propolis on arachidonic acid metabolism." | 3.69 | The effect of propolis and its components on eicosanoid production during the inflammatory response. ( Calder, PC; Mirzoeva, OK, 1996) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 3.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| "In the present study we investigated the effect of nordihydroguaiaretic acid (NDGA), indomethacin, and cortisone on trypsin-induced acute inflammation in the hamster cheek pouch." | 3.68 | Anti-inflammatory agents inhibit leukocyte accumulation and vascular leakage induced by trypsin and trypsin-digested serum in hamster cheek pouch. ( Heideman, M; Roxvall, L; Sennerby, L, 1993) |
| "This study has examined the effects of prostaglandins E2 and F2a (PGE2 and PGF2a) and indomethacin on cellular inflammation in fetal rabbits." | 3.68 | Effects of prostaglandins and indomethacin on the cellular inflammatory response following surgical trauma in fetal rabbits. ( Argenta, LC; Morykwas, MJ; Perry, SL, 1993) |
| "We studied the effect of either 1) immunogenic inflammation caused by aerosolized ovalbumin or 2) neurogenic inflammation caused by aerosolized capsaicin in vivo on guinea pig tracheal smooth muscle (TSM) contractility in vitro." | 3.68 | Effect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis. ( Arbetter, K; Leff, AR; Mitchell, RW; Ndukwu, IM; Solway, J, 1993) |
| " Local administration of anti-inflammatory drugs such as dexamethasone, indomethacin, or a PLA2 inhibitor such as p-bromophenacyl bromide significantly inhibited exudate volume, cellular influx, granuloma formation, exudate PGE2 levels and PLA2 activity, to varying degrees." | 3.68 | Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation. ( Moreno, JJ, 1993) |
| "In BALB/cAnPt (BALB/c) mice, the intraperitoneal injection of pristane induces the formation of chronic oil granulomatous tissue and a high incidence of plasmacytomas (PCT)." | 3.68 | Pristane induces an indomethacin inhibitable inflammatory influx of CD4+ T cells and IFN-gamma production in plasmacytoma-susceptible BALB/cAnPt mice. ( Degrassi, A; McDonald, AH, 1993) |
| "The antiinflammatory activity of a new 14-membered macrolide antibiotic, roxithromycin, was evaluated in various rat models including carrageenan- and poly-L-arginine-induced hind-paw oedema, croton oil inflamed ear assay and polyester sponge granuloma." | 3.68 | Macrolide antibiotics as antiinflammatory agents: roxithromycin in an unexpected role. ( Agen, C; Blandizzi, C; Costa, M; Danesi, R; Del Tacca, M; Favini, P; Stacchini, B, 1993) |
| " MPO was measured in the mouse ear after injection of interleukin-1 beta, in the rat paw after carrageenan-induced edema and in the lung of sensitized guinea pigs after ovalbumin inhalation." | 3.68 | Measurement of MPO activity as model for detection of granulocyte infiltration in different tissues. ( Szelenyi, I; Werner, U, 1992) |
| "The actions and interactions of putative mediators of inflammation, such as substance P (SP), histamine, bradykinin and prostaglandins (PGE2) were studied in human skin." | 3.68 | Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin. ( Håkanson, R; Wallengren, J, 1992) |
| "6MNA, the active metabolite of the nonacidic antiinflammatory drug nabumetone, was investigated using intravenous administration for effects on (1) carrageenan paw edema and gastric irritancy compared with either oral nabumetone or both oral and intravenous indomethacin when given acutely and (2) gastrointestinal irritancy when given in repeat dosing studies." | 3.68 | Antiinflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Comparative studies with indomethacin. ( Blower, PR; Gentry, C; Kelvin, AS; Melarange, R; Neil, C; O'Connell, C; Toseland, CD, 1992) |
| "The role of histamine in neutrophil infiltration and vascular permeability response in carrageenin air pouch inflammation in rats was examined." | 3.68 | Downward regulation of neutrophil infiltration by endogenous histamine without affecting vascular permeability responses in air-pouch-type carrageenin inflammation in rats. ( Hirasawa, N; Mue, S; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1991) |
| "The effect of loxoprofen-Na, a novel non-steroidal anti-inflammatory drug with a prodrug property, on prostaglandin (PG) levels in the inflammatory tissue was investigated with a carrageenin-induced pleurisy model in rats." | 3.68 | Inhibition of prostaglandin production in the inflammatory tissue by loxoprofen-Na, an anti-inflammatory prodrug. ( Asami, M; Iizuka, Y; Kojima, T; Matsuda, K; Sugimoto, M, 1991) |
| "Systemic capsaicin and an analogue, olvanil (NE-19550, 4-hydroxy-3-methoxyphenyl methyl-9Z-octadecenamide), were tested for antinociceptive activity in a model of persistent pain produced by the subcutaneous injection of formalin into the rodent hind paw." | 3.68 | Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw. ( Dickenson, A; Dray, A, 1991) |
| "This study was designed to determine the effect of local inflammation on nickel subsulfide (Ni3S2) carcinogenesis." | 3.68 | Prevention of nickel subsulfide carcinogenesis by local administration of Mycobacterium bovis antigen in male F344/NCr rats. ( Kasprzak, KS; Ward, JM, 1991) |
| "The steroid-saving activity of the highly potent new non-steroid antiinflammatory agent CGP 28238 was determined in rat carrageenin paw edema and in primary phase of adjuvant arthritis in comparison with indomethacin." | 3.68 | Steroid-saving potency of nonsteroidal antiinflammatory agents--a reevaluation with the new agent CGP 28238 in rat inflammatory models. ( Giessler, J; Hirschelmann, R; Pöch, G; Rafler, I; Rickinger, O, 1991) |
| "Using an experimental model for allergic inflammation of the air pouch type in rats, the effects of dexamethasone and indomethacin on leukocyte infiltration and level of chemotactic activity in the inflammatory exudate were examined to clarify the mechanisms of anti-inflammatory effects of glucocorticoids." | 3.67 | Reduction by dexamethasone of chemotactic activity in inflammatory exudates. ( Kurihara, A; Ohuchi, K; Tsurufuji, S, 1984) |
| "The involvement of histamine, the cyclooxygenase system and the kallikrein-kinin system in the generation of the Sephadex inflammation was investigated by in vivo-blocking of these systems." | 3.67 | The involvement of histamine, the cyclooxygenase system and the kallikrein-kinin system in acute inflammation generation, demonstrated with the Sephadex model in rats. ( Egger, G; Macheiner, U, 1987) |
| " Furthermore, the complete reversal of indomethacin potentiation of allergic inflammation by addition of PGE2 in low concentration advocates a regulatory function of the endogenous and locally formed PGE2." | 3.67 | Dual action of prostaglandin E2 in allergic inflammation. ( Dahlén, SE; Hedqvist, P; Raud, J, 1989) |
| " Indomethacin or dexamethasone increased intestinal injury by PG-APS by inducing mid-small bowel and cecal parenchymal hemorrhage." | 3.67 | Eicosanoid regulation of acute intestinal vascular permeability induced by intravenous peptidoglycan-polysaccharide polymers. ( Sartor, RB; White, JJ; Woolverton, CJ, 1989) |
| "The mechanism of the anti-inflammatory effect of proglumetacin maleate, a novel indomethacin derivative, was examined in vivo in an allergic air pouch inflammation model in rats." | 3.67 | Effects of proglumetacin maleate and its major metabolites on allergic air pouch inflammation in rats. ( Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y, 1987) |
| " In vivo, ebselen is a weak oral inhibitor of carrageenan paw oedema and adjuvant arthritis in the rat, differentiating it from classical NSAIDs such as indomethacin and diclofenac." | 3.67 | Ebselen: a new approach to the inhibition of peroxide-dependent inflammation. ( Kuhl, P; Leyck, S; Parnham, MJ; Schalkwijk, J; van den Berg, WB, 1987) |
| "The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated." | 3.67 | Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986) |
| "Acetylsalicic acid and indomethacin suppress the increase of alpha-amanitin sensitive RNA synthesis (pre-mRNA), but not that of alpha-amanitin resistant RNA synthesis (pre-rRNA), which occur in liver nuclei a few hours after the start of turpentine-induced inflammation in the skin." | 3.67 | Prostaglandin synthesis and early biochemical events in the liver cells during the acute-phase response. ( Aletti, MG; Bernelli-Zazzera, A; Ferioli, ME; Piccoletti, R; Scalabrino, G, 1987) |
| " Dexamethasone, but not indomethacin, BW755C, mepyramine or methysergide inhibited development of paw oedema; none of these drugs were effective in the pleurisy model." | 3.67 | Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. ( Peers, SH, 1988) |
| "In cats with an acute experimental inflammation in the right knee joint the effects of acetylsalicylic acid (ASA) and indomethacin on the discharge properties of single fine myelinated and unmyelinated articular afferent units were tested." | 3.67 | Effects of acetylsalicylic acid and indomethacin on single groups III and IV sensory units from acutely inflamed joints. ( Heppelmann, B; Pfeffer, A; Schaible, GH; Schmidt, RF, 1986) |
| "In order to assess the role of inflammation and its components in spontaneous cure of Strongyloides ratti infestation, rats were treated with non-steroid anti-inflammatory agents (indometacin; sodium salicylate) or with antagonists of certain mediators (dexchlorpheniramin; cyproheptadin, promethazin)." | 3.67 | [The role of inflammation in the spontaneous elimination of Strongyloides ratti infestation]. ( Bailenger, J; Lacassie, A, 1986) |
| "The addition of indomethacin to concanavalin A (Con A)-induced cultures of human peripheral blood leukocytes (PBL) caused an increase in interferon response, regardless of whether the PBLs were derived from multiple sclerosis (MS) patients or from control donors." | 3.67 | Influence of prostaglandin E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple sclerosis patients and healthy donors. ( Billiau, A; Carton, H; Deckmyn, H; Vervliet, G, 1985) |
| " To explore a possible therapeutic application of substances that inhibit 15-LO of soybean in vitro, we have tested several active compounds, namely nordihydroguaiaretic acid (NDGA), phenidone, diethylcarbamazine and mefenamic acid, on the following in vivo inflammation models in the rat: plantar oedema induced by carrageenin; cutaneous vascular hyperpermeability induced by pafacether; pleurisy induced by carrageenin." | 3.67 | In vivo anti-allergic and anti-inflammatory effects of drugs that inhibit lipoxygenase activity in vitro. ( Braquet, P; Clostre, F; Etienne, A; Soulard, C; Touvay, C, 1985) |
| " Aspirin also reduced the levels of PGE2 and TXB2 in the exudate but did not consistently affect PMN influx, thereby confirming that inhibition of cyclo-oxygenase does not reduce cell migration in inflammation." | 3.66 | The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation. ( Moncada, S; Salmon, JA; Simmons, PM, 1983) |
| "We have recently shown that indomethacin and ASA diminish the elevated blood flow, protein exudation, and leukocyte infiltration during acute inflammation induced by killed Escherichia coli, the reversed Arthus reaction, or zymosan-activated plasma (ZAP; C5ades-arg) in rabbit skin." | 3.66 | Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits. ( Issekutz, AC, 1983) |
| " Fenflumizole was comparable to or weaker than indomethacin in models of acute inflammation (carrageenin paw oedema and pleurisy, rats, ultraviolet erythema, guinea-pigs) and stronger than indomethacin as an analgesic (writhing, mice)." | 3.66 | Pharmacodynamics and toxicology of fenflumizole, a new non-steroidal anti-inflammatory imidazole derivative. ( Corell, T; Hasselmann, G, 1983) |
| "The effect of ethanol on the anti-inflammatory actions of indomethacin was studied using carrageenan-induced edema in the paw of the rat as the test for acute inflammation." | 3.66 | Indomethacin-ethanol interactions on acute inflammation. ( Greizerstein, HB, 1983) |
| "The effect of indomethacin and dexamethasone on an allergic inflammation in rats, a novel model of allergic inflammation of an air pouch type, was examined." | 3.66 | A possible role of arachidonate metabolism in allergic air pouch inflammation in rats. Anti-inflammatory effect of indomethacin and dexamethasone and the level of prostaglandin E2 in the exudate. ( Kanaoka, K; Levine, L; Ohuchi, K; Tsurufuji, S; Yoshino, S, 1982) |
| "Twenty-three patients with rheumatoid arthritis and 9 patients with other forms of rheumatic diseases were treated for 20 days with 420 mg glucametacin per day, given as three 140 mg capsules." | 3.66 | Further studies on glucametacin in rheumatoid arthritis and in other chronic types of rheumatism. ( Capelli, L; Chianese, V; Giordano, M; La Montagna, G, 1981) |
| "The influence of the free radical scavenger 2,4-tetra-O-methyl-furfurylidene-sorbitol (MSF) on the carrageenan-induced hind-paw inflammation in rats as well as its influence on the anti-inflammatory and toxic activities of indomethacin is evaluated in comparison with thiola, thioctic acid, silymarin, reduced glutathione and propylgallate." | 3.66 | Influence of 2,4-tetra-O-methyl-furfurylidene-sorbitol (MSF) on carrageenan-induced inflammation and anti-inflammatory and toxic effects of indomethacin in rats. ( Baggio, G; Poggioli, R; Zanoli, P, 1982) |
| " Carbon tetrachloride (1,0 ml/Kg, os) is able in depressing significantly the rat paw oedema provoked by carrageenan, but does not potentiates the anti-inflammatory action of non-steroid agents." | 3.66 | [Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents]. ( Curzio, M; Negro, F; Paradisi, L; Parola, M; Torrielli, MV, 1981) |
| " The anti-inflammatory activity of Indomethacin, Oxametacine and Phenylbutazone was evaluated in these animals using paw oedema provoked by carrageenan granulomas induced by cotton pellets and polyarthritis induced by Freund complete adjuvant." | 3.66 | The influence of experimental hypo- and hyperthyroid states on acute and chronic inflammatory reactions: modified response to non-steroidal anti-inflammatory agents. ( Cirillo, R; Curzio, M; Franzone, J; Sena, L; Torrielli, MV, 1981) |
| "A nonlymphokine mediator of hyperemia has been shown to be secreted by both rabbit peritoneal exudate cells stimulated with 5% glycogen and by concanavalin A treated cells from afferent lymph of sheep." | 3.66 | Secretion of a hyperemia-inducing moiety by mitogen or glycogen stimulated mononuclear inflammatory cells of sheep and rabbit. ( Hay, JB; Vadas, P, 1980) |
| "Topically applied indomethacin before and after pars plana lensectomy-vitrectomy in an experimental rabbit model reduces postoperative inflammation, as demonstrated by a statistically significant inhibition of protein elevation in the ocular fluid." | 3.66 | Anti-inflammatory action of topical indomethacin. ( Larson, B; Lavery, GW; Peyman, GA; Raichand, M, 1980) |
| "In rats pretreated with indomethacin, injection of PGE1 (prostaglandin E1) with carrageenan potentiated the carrageenan paw oedema." | 3.66 | Characteristics of prostaglandin E1 potentiation of inflammatory activity of some agents. ( Thomas, G, 1980) |
| "A model is described of acute inflammation in the pleural cavity of rats using calcium pyrophosphate as the irritant." | 3.65 | Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation. ( Capasso, F; Deporter, DA; Dunn, CJ; Giroud, JP; Willoughby, DA; Yamamoto, S, 1975) |
| " Indomethacin inhibited the carrageenin-oedema in normal rats, but failed to further suppress the poorly developed delayed phase of the carrageenin-induced inflammation in EFAD rats." | 3.65 | Effects of anti-inflammatory drugs on the carrageenin-induced hind paw inflammation of rats deprived of endogenous precursors of prostaglandins. ( Bonta, IL; Bult, H, 1977) |
| "Caffeine has been found to potentiate the acute anti-inflammatory activity of aspirin, indomethacin, and phenylbutazone, but not the activity of sodium salicylate or hydrocortisone, in the carrageenan pleurisy or hindlimb models of inflammation in the rat." | 3.65 | Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat. ( Ellis, CH; Selph, JL; Truax, JF; Vinegar, R; Welch, RM; White, HL, 1976) |
| "The topical effects of N0164 (a phenyl phosphonate derivative which is a partially selective antagonist of prostagladin E2), indomethacin and triamcinolone acetonide have been shown to reduce the erythema and ear weight gain from inflammation induced by experimental contact allergic eczema." | 3.65 | Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis. ( Lowe, NJ; Stoughton, RB; Virgadamo, F, 1977) |
| "Indomethacin treatment before lens extraction and vitrectomy-lensectomy reduces postoperative inflammation as measured by protein determination of the ocular fluid." | 3.65 | Indomethacin inhibition of prostaglandin-mediated inflammation following intraocular surgery. ( Huang, K; Janevicius, R; McGetrick, J; Peyman, GA, 1977) |
| " In normal animals the administration of indomethacin and sodium salicylate cause similar effects to thrombocytopenia whereas the injection of human plasma fraction affects only the leucocyte migration." | 3.65 | Platelets, prostaglandins and inflammation. ( Ford-Hutchinson, AW; Penington, DG; Smith, MJ; Walker, JR, 1976) |
| "Evidence for the effectiveness of ketoprofen in animal models of inflammation and its antipyretic effect is reviewed." | 3.65 | Some pharmacological and toxicological studies on ketoprofen. ( Ducrot, R; Guyonnet, JC; Julou, L; Pasquet, J, 1976) |
| "gov NCT01747252) revealed relatively high bioavailability and two distinctly separated plasma concentration peaks at 1 and 5 h." | 2.79 | A novel red grape cells complex: health effects and bioavailability of natural resveratrol. ( Azachi, M; Danon, A; Hagay, Y; Katz, A; Yatuv, R, 2014) |
| "Indomethacin was found non-inferior to ketorolac for comparison of aqueous flare at postoperative Days 1 and 7 (Day 1: 95% CI: -2." | 2.78 | Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery. ( Allaire, CM; Kodjikian, L; Kruse, FE; Weber, M; Zagorski, Z, 2013) |
| "Indomethacin is a known immune modulator that inhibits cyclooxygenase." | 2.73 | Pharmacological prevention of the deleterious effects of cardiopulmonary bypass. ( Afrakhteh, M; Givtaj, N; Hassantash, SA; Omrani, GR, 2007) |
| "While inflammation is very significant in the abolition of pathogens and other causes of soreness, a protracted inflammatory procedure takes to outcomes in chronic disease that might finally affect in organ failure or damage." | 2.72 | Contemporary advances of cyclic molecules proposed for inflammation. ( Neha, K; Wakode, S, 2021) |
| "The goal of this study was to look for correlations between the severity of chronic inflammatory joint disease and pharmacokinetic parameters of nonsteroidal antiinflammatory drugs." | 2.68 | Influence of severity of chronic inflammatory joint disease on the pharmacokinetics of indomethacin and etodolac. ( Goasguen, J; Guggenbuhl, P; Jacquelinet, C; Lapicque, F; Le Dantec, P; Netter, P; Pawlotsky, Y; Perdriger, A; Veillard, E, 1996) |
| "Indomethacin is a nonsteroidal anti-inflammatory drug with potent antipyretic, analgesic, and anti-inflammatory activity that has been effectively used in the management of mild-to-moderate pain since the mid-1960s." | 2.50 | Role of indomethacin in acute pain and inflammation management: a review of the literature. ( Nalamachu, S; Wortmann, R, 2014) |
| " Epidemiological studies have shown that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing AD and delays its onset." | 2.43 | Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. ( Praticò, D; Townsend, KP, 2005) |
| "Inflammation is a protective biological process, but under extreme conditions, it can become highly dreadful to the body." | 1.91 | Synthesis, Molecular Docking and ADME Prediction of 1H-indole/5- substituted Indole Derivatives as Potential Antioxidant and Anti- Inflammatory Agents. ( Kumari, A; Singh, RK, 2023) |
| "Indomethacin (10 mg/kg BW) was given orally as the standard drug." | 1.91 | Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation. ( Baro, MR; Das, B; Das, M; Kalita, A; Sarma, K, 2023) |
| "Lafutidine (LAF) is a novel histamine H2 receptor antagonist with a mucosal protective action." | 1.91 | Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota. ( Chen, J; Chen, X; Guo, J; Liang, H; Liu, Q; Lou, C; Luo, Y; Song, C; Sun, S; Wang, B; Xu, X; Zhao, J; Zhong, W; Zhu, L, 2023) |
| "Cardiac inflammation is generally accompanied by hypoxia, while myocardial injury and an abnormal microenvironment caused by hypoxia tend to suppress the efficacy of common anti-inflammatory drugs." | 1.72 | Hypoxia-Activated Prodrugs with Dual COX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia. ( Gou, S; Liu, Z; Wang, C; Zhou, W, 2022) |
| "Inflammation is the main driver of the aggravation of arteriosclerosis, and the complex inflammatory response in plaque is usually the result of the interaction of various cells and cytokines." | 1.72 | Programmed prodrug breaking the feedback regulation of P-selectin in plaque inflammation for atherosclerotic therapy. ( Duan, Y; Gong, K; Guo, Q; Jing, H; Li, Z; Lin, J; Tian, Y; Wang, L; Wang, Q; Wu, Z; Yang, X, 2022) |
| "Alzheimer's disease is a progressive neurodegenerative disease, and its incidence is expected to increase as the global population ages." | 1.62 | Design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents. ( Huang, W; Huang, Y; Ma, L; Wang, R; Yang, G, 2021) |
| "Acute lung injury was efficiently treated by inhibiting the cascade of inflammation, and reducing the inflammatory response in the lung." | 1.62 | Design, synthesis and structure-activity relationship studies of 4-indole-2-arylaminopyrimidine derivatives as anti-inflammatory agents for acute lung injury. ( Chen, T; Wei, Y; Zhang, X; Zhao, H; Zhu, G, 2021) |
| "Adjuvant arthritis was induced by single intraplantar injection of complete Freund's adjuvant (CFA) in the left hind paw of adult female Wistar rats." | 1.56 | Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats. ( Chopra, K; Dhaliwal, J; Dhaliwal, N; Dharavath, RN; Kumar, A, 2020) |
| "Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate-Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline)." | 1.56 | Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats. ( Atusiimirwe, JK; Ayikobua, ET; Kalange, M; Kasolo, J; Kasozi, KI; Matama, K; Munanura, EI; Namulema, J; Nansunga, M; Okpanachi, AO; Semuyaba, I; Ssempijja, F; Zirintunda, G, 2020) |
| "One cause of dysbiosis is inflammation." | 1.56 | Histamine H ( Ichikawa, T; Kawakami, F; Kawashima, R; Maekawa, T; Tamaki, S, 2020) |
| "Icariin was injected in a dose of 50 mg/kg." | 1.51 | Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways. ( Eid, BG; El-Shitany, NA, 2019) |
| " Therefore, it is of increasing importance to configure new dosing strategies and alleviate the side effects of NSAIDs." | 1.48 | Anti-inflammatory polymersomes of redox-responsive polyprodrug amphiphiles with inflammation-triggered indomethacin release characteristics. ( Deng, Z; Hu, J; Liu, G; Liu, S; Tan, J, 2018) |
| "Most drugs used to treat pain and inflammation have potential side effects, which makes it necessary to search for new sources of bioactive molecules." | 1.48 | LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice. ( Alencar Filho, EB; Almeida, JRGDS; Barreiro, EJL; Diniz, TC; Lavor, ÉM; Lima, LM; Lima-Saraiva, SRG; Mendes, RL; Oliveira Júnior, RG; Silva, JC; Silva, MGE; Soares, JMD, 2018) |
| "Inflammation is a local defensive reaction of a host to cellular injury or infection." | 1.43 | Acacia ferruginea inhibits inflammation by regulating inflammatory iNOS and COX-2. ( Guruvayoorappan, C; Sakthivel, KM, 2016) |
| "Inflammation was induced by intraplantar (i." | 1.43 | [Inhibition of prostaglandins synthesis in the inflamed site results in opioid-mediated hypoalgesia in rats]. ( Hong, Y; Huang, J; Wu, J; Yang, HZ, 2016) |
| " Furthermore, 1c could suppress the progress of carrageenan-induced hind paw edema at a dosage of 50 mg/kg/day and dose-dependently ameliorate the development of adjuvant-induced arthritis (AIA)." | 1.42 | Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents. ( Chen, L; He, J; He, L; Lei, L; Ma, L; Peng, F; Shao, M; Tang, M; Wei, Z; Wu, Y; Zhu, J, 2015) |
| " Hence, inflammatory diseases may impose variability in drug bioavailability through alterations in the intestinal expression and activity of drug transporters." | 1.42 | Changes of Absorptive and Secretory Transporting System of (1 → 3) β-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat. ( Aketagawa, J; Hayashi, M; Iida, A; Ito, Y; Oda, T; Ouchi, S; Takizawa, Y; Tomita, M, 2015) |
| "CAPE-indomethacin hybrid was able to significantly attenuate the clinical grading and the PGE2 aqueous levels only at the highest dose (0." | 1.42 | Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation. ( Bucolo, C; Drago, F; Modica, MN; Pittalà, V; Romano, GL; Romeo, G; Salerno, L; Salomone, S; Siracusa, MA, 2015) |
| "Treatment with indomethacin significantly decreased COX-1 and COX-2 transcript expression." | 1.40 | Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice. ( Boehme, M; Frahm, C; Guenther, M; Jaenisch, N; Liebmann, M; Stahr, A; Witte, OW, 2014) |
| " Histological examination revealed normal architecture and no significant adverse effects were observed on the liver, kidney, heart, lung or ovaries and testicles." | 1.40 | Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats. ( Bravo, J; Morales, G; Olivares, A; Paredes, A, 2014) |
| " Incidentally, when NSAID use is combined with exercise there is some evidence that this effect may be exacerbated; however, this hypothesis has not been directly tested in a controlled experiment." | 1.39 | Indomethacin in combination with exercise leads to muscle and brain inflammation in mice. ( Davis, JM; Enos, RT; McClellan, JL; Murphy, EA, 2013) |
| "The edema was produced in a dose- and time-dependent manner." | 1.39 | Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms. ( Laraba-Djebari, F; Sebia-Amrane, F, 2013) |
| "Podophyllotoxin is a natural product that inhibits the polymerization of tubulin and has served as a prototype for the development of diverse antitumor agents in clinical use, such as etoposide, teniposide and etopophos." | 1.39 | Analgesic and anti-inflammatory activity of podophyllotoxin derivatives. ( Abad, A; Del Olmo, E; Guerrero, E; López-Pérez, JL; Montenegro, G; San Feliciano, A, 2013) |
| "Pretreatment with candesartan for 10 days reduced significantly the ulcer index induced by indomethacin injection." | 1.38 | Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats. ( Awad, AS; El Morsy, EM; Kamel, R, 2012) |
| " Compared with the commercial tablet, the relative oral bioavailability of IND-nanomedicines was significantly enhanced." | 1.38 | Assembled nanomedicines as efficient and safe therapeutics for articular inflammation. ( Che, L; He, H; Jia, Y; Li, S; Li, X; Liu, Y; Zhang, J; Zhou, J; Zhou, X; Zhu, Y, 2012) |
| "Dillapiole and safrole were isolated and purified using column chromatography." | 1.37 | The anti-inflammatory activity of dillapiole and some semisynthetic analogues. ( Agostinho, LA; Brandt, CA; de Souza, T; Motter Magri, FM; Parise-Filho, R; Pastrello, M; Pereira Camerlingo, CE; Polli, MC; Ribeiro, RR; Silva, GJ, 2011) |
| "Inflammation was induced by injection of 0." | 1.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| "Inflammation is related to neutrophil infiltration and the production of neutrophil-derived mediators and free radicals." | 1.36 | Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models. ( Aslan, A; Aygun, H; Cakir, A; Halici, Z; Odabasoglu, F; Suleyman, H; Tanas, S, 2010) |
| "mays husk decoction for the treatment of pain and inflammatory conditions in Nigerian folk medicine." | 1.36 | Analgesic and anti-inflammatory effects of aqueous extract of Zea mays husk in male Wistar rats. ( Ibidapo, AJ; Negedu, MN; Oguntoye, SO; Olaniran, SO; Onasanwo, SA; Owoyele, BV; Oyeleke, SA; Sanya, JO; Soladoye, AO, 2010) |
| "The same procedure suppressed allodynia and hyperalgesia in the cancer model, but the suppression was weak when compared with that in the inflammation model." | 1.36 | Differences between orofacial inflammation and cancer pain. ( Harano, N; Hidaka, K; Inenaga, K; Kai, A; Nakanishi, O; Ono, K, 2010) |
| " For these studies, animals were dosed with CP-154,526 (3, 10, 30 mg/kg) and NBI 27914 (1-30 mg/kg) 1 h prior to the assessment of tactile, thermal or mechanical hypersensitivity, respectively." | 1.36 | Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. ( Cummons, T; Harrison, JE; Hummel, M; Kennedy, JD; Lu, P; Mark, L; Whiteside, GT, 2010) |
| "Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2)." | 1.36 | Celecoxib induces tolerance in a model of peripheral inflammatory pain in rats. ( Bakhle, YS; Camêlo, VM; de Francischi, JN; Dos Reis, WG; Paiva-Lima, P; Rezende, RM, 2010) |
| " Compound 4 had good efficacy (52% and 41% reversal of allodynia at 2 and 4h post-dose, respectively) in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain when dosed orally at 10mg/kg." | 1.35 | Imidazopyridines: a novel class of hNav1.7 channel blockers. ( Abbadie, C; Dean, B; Duffy, JL; Felix, JP; Garcia, ML; Hoyt, SB; Jochnowitz, N; Kaczorowski, GJ; Karanam, BV; Li, X; London, C; Lyons, KA; Martin, WJ; McGowan, E; Parsons, WH; Priest, BT; Smith, MM; Tschirret-Guth, R; Warren, VA; Williams, BS, 2008) |
| "Hypertension was induced by DOCA-salt." | 1.35 | Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009) |
| "The indomethacin-induced increase of macroscopic and microscopic scores of intestinal inflammation (both P < 0." | 1.35 | Afferent nerve sensitivity is decreased by an iNOS-dependent mechanism during indomethacin-induced inflammation in the murine jejunum in vitro. ( Hausmann, M; Hu, WC; Karpitschka, M; Kasparek, MS; Kreis, ME; Müller, MH; Pesch, T; Rogler, G; Sibaev, A; Xue, B, 2009) |
| "Methods used included the in-vitro inhibition of cyclooxygenase-1 and -2, in-vivo evaluation of anti-inflammatory activity by air pouch and peritonitis models and the pharmacokinetic profile after intravenous (3 mg/kg) and oral (3 and 6 mg/kg) dosing to rats." | 1.35 | Preclinical pharmacokinetic and pharmacodynamic evaluation of thiazolidinone PG15: an anti-inflammatory candidate. ( da Silva, TG; Dalla Costa, T; de Lima, Mdo C; Galdino, SL; Pitta, Ida R; Uchôa, Fde T, 2009) |
| "The pathogenesis of gastric ulcer is associated with remodeling of extracellular matrix (ECM) by various matrix metalloproteinases (MMPs)." | 1.35 | Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. ( Ganguly, K; Swarnakar, S, 2009) |
| "Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model." | 1.35 | Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009) |
| "Chronic inflammation has long been associated with neoplastic progression." | 1.35 | Leukotriene B4 creates a favorable microenvironment for murine melanoma growth. ( Bachi, AL; Carneiro, CR; Correa, M; Jasiulionis, MG; Kim, FJ; Lopes, JD; Nonogaki, S, 2009) |
| "Globoid cell leukodystrophy (GLD) or Krabbe disease is a neurodegenerative disorder caused by the deficiency of the lysosomal enzyme galactocerebrosidase (GALC)." | 1.35 | Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophy. ( Abraham, RM; Curtis, M; Hooper, DC; Luzi, P; Rafi, MA; Wenger, DA, 2009) |
| "The development of hyperalgesia was dose dependently prevented by the NSAID indomethacin (ED50=2." | 1.35 | Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw. ( Chen, JJ; Ding, X; Dong, H; Johnson, EJ; Kumar, GN; Magal, E; Manning, BH; Sun, H, 2008) |
| " Administration of RBuOH at the same dosage (50, 100 and 200 mg/kg) reduced significantly (P<0." | 1.35 | Anti-ulcer, anti-inflammatory and antioxidant activities of the n-butanol fraction from Pteleopsis suberosa stem bark. ( Biasini, T; Braca, A; D'Angelo, V; De Leo, M; De Pasquale, R; Germanò, MP; Miano, TC; Sanogo, R, 2008) |
| "Indomethacin is widely used to treat inflammatory and prevent adverse events which frequently accrue in biotherapy." | 1.34 | Indomethacin enhances the cytotoxicity of recombinant human lymphotoxin alpha on tumor cells by suppressing NFkappaB signaling. ( Li, G; Li, R; Liu, Y; Pan, W; Shen, Y; Tan, J; Wang, J; Wang, L; Wang, Z; Wu, F; Wu, J; Xu, Q; Yang, T, 2007) |
| "Acemetacin was rapidly converted to indomethacin after its administration." | 1.34 | Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin. ( Castañeda-Hernández, G; Chávez-Piña, AE; Dicay, M; McKnight, W; Wallace, JL, 2007) |
| "In contrast, analgesia, sedation and catalepsy were not observed in this dose range, but were apparent at 100 mg/kg." | 1.33 | Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. ( Boulet, JM; Chaffer, SM; Elsemore, DA; Gottshall, SL; Harrison, JE; Koetzner, L; Lee, G; Mark, L; Miller, W; Pearson, MS; Rabadi, L; Rotshteyn, Y; Shan, S; Tafesse, L; Toth, M; Turchin, PI; Valenzano, KJ; Whiteside, GT, 2005) |
| "Trimetazidine did not produce any behavioural impairment as revealed by the mouse rotarod." | 1.33 | Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents. ( Abdel-Salam, OM; El-Batran, S, 2005) |
| "Indomethacin was less effective, though tissue prostaglandin E2 but not leukotriene B4 levels were reduced." | 1.33 | The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo. ( Andrews, G; Colville-Nash, P; Freemantle, C; Lam, C; Papworth, J; Willis, D; Willoughby, D, 2005) |
| "When indomethacin in methanol was photo-irradiated with an Hg lamp, methyl ester, ethyl ester, and gamma-lactone derivatives of indomethacin were produced." | 1.33 | Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 Cells. ( Chao, SH; Chen, FA; Lee, CJ; Wang, CC; Wu, AB, 2005) |
| "We previously demonstrated that a novel hydrophilic gamma-tocopherol (gamma-Toc) derivative, gamma-tocopherol-N,N-dimethylglycinate hydrochloride (gamma-TDMG) converts to gamma-Toc in the mouse skin and has a higher bioavailability than gamma-Toc itself." | 1.33 | Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin. ( Karube, Y; Kobayashi, S; Takata, J; Watanabe, T; Yamazaki, A; Yoshida, E, 2006) |
| "Pretreatment with indomethacin completely reversed both of the therapeutic effects of dalteparin, whereas pretreatment with NS-398, a selective inhibitor of cyclooxygenase-2, did not." | 1.33 | Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats. ( Harada, N; Okajima, K; Uchiba, M, 2006) |
| "2% at 1 and 2h after dosing (P<0." | 1.32 | The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Shenawy, SM, 2003) |
| "Indomethacin is a clinically applied nonsteroidal antiphlogistic, and in previous studies in the rat, it has been found to induce an inflammatory reaction in the small intestine characterized by edema and reddening of the intestinal epithelium, ulceration, and dysregulation in the intestinal-epithelial barrier function." | 1.32 | Effect of N-acetylcysteine on microcirculation of mucosa in rat ileum in a model of intestinal inflammation. ( Ruh, J; Schmidt, E; Vogel, F, 2003) |
| "Pretreatment with aspirin or bilirubin at low micromolar concentrations protected endothelial cells from hydrogen peroxide-mediated toxicity." | 1.32 | Heme oxygenase-1 induction may explain the antioxidant profile of aspirin. ( Abate, A; Becker, JC; Dennery, PA; Grosser, N; Oberle, S; Pohle, T; Schröder, H; Seidman, DS; Vreman, HJ, 2003) |
| "Weight-losing untreated cancer patients had elevated resting energy expenditure compared to undernourished non-cancer patients (23." | 1.32 | Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. ( Bosaeus, I; Daneryd, P; Hyltander, A; Körner, U; Lundholm, K, 2004) |
| " Both low- and high-frequency EA combined with INDO enhanced antihyperalgesia compared to each component alone, and 10 Hz but not 100 Hz EA significantly reduced CFA-induced hind paw edema." | 1.32 | Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats. ( Berman, BB; Lao, L; Ren, K; Wang, X; Zhang, RX, 2004) |
| "Pretreatment with PAT prevented the hyperalgesia and maintained the body temperature within the normal range and was accompanied by a down-regulation of the levels of pro-inflammatory cytokines and PGE(2) in the liver." | 1.31 | Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat. ( Dardenne, M; Pléau, JM; Saadé, NE; Safieh-Garabedian, B, 2002) |
| "Acute inflammation was induced by sub-plantar injection of carrageenan (1%) in the rat hind paw." | 1.31 | Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Batran, S; El-Shenawy, SM, 2002) |
| "2." | 1.31 | Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation. ( Bakhle, YS; Chaves, CT; Ferreira-Alves, DL; Francischi, JN; Lima, AS; Moura, AC; Rocha, OA, 2002) |
| "In these studies, carrageenan-induced thermal hyperalgesia was evaluated in the mouse and the role of NGF and the MAPK pathway investigated." | 1.31 | Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway. ( Bingham, S; Davey, PT; Parsons, AA; Raval, P; Rogers, D; Sammons, MJ, 2000) |
| "Metronidazole was more potent than amoxicillin/clavulanic acid and anti-tumour necrosis factor in improving the indometacin-induced small bowel inflammation." | 1.31 | Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model. ( Ceuppens, JL; Colpaert, S; De Greef, B; Geboes, K; Liu, Z; Rutgeerts, P, 2001) |
| "The histamine-induced increase in the content of VEGF protein in the conditioned medium was inhibited by the cyclic AMP antagonist Rp-cAMP (IC(50) 6." | 1.31 | Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors. ( Ghosh, AK; Hirasawa, N; Ohuchi, K, 2001) |
| "Local inflammation was induced by subcutaneous injection of turpentine (100 microl/mouse)." | 1.30 | Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic inflammation. ( Conn, CA; Kluger, MJ; Kozak, W; Rudolph, K; Soszynski, D, 1997) |
| "Oedema was induced by: a) AA (0." | 1.30 | Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation. ( González, R; Ledón, N; Romay, C, 1998) |
| "Amentoflavone was also found to inhibit cyclooxygenase from guinea-pig epidermis without affecting lipoxygenase." | 1.30 | Amentoflavone, a plant biflavone: a new potential anti-inflammatory agent. ( Chang, HW; Kang, SS; Kim, HK; Kim, HP; Son, KH, 1998) |
| "Inflammation was induced by daily interplantar injection of 100 microl of Freund's complete adjuvant into the left hind paw of the rat." | 1.30 | Effect of somatostatin on beta-endorphin release in rat experimental chronic inflammation. ( Corsi, MM; Ferrero, ME; Fulgenzi, A; Gaja, G; Pravettoni, G; Tiengo, M, 1999) |
| "This inflammation was characterized by oedema and granulocyte infiltration." | 1.30 | Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw. ( Hollenberg, MD; Sharkey, KA; Vergnolle, N; Wallace, JL, 1999) |
| "Indomethacin is a widely used nonsteroidal antiphlogistic compound used-among others-for the treatment of rheumatoid arthritis in humans." | 1.30 | Indomethacin-induced disturbances in villous microcirculation in the rat ileum. ( Klar, E; Ruh, J; Schmidt, E; Vogel, F, 1999) |
| "5 Pretreatment with indomethacin completely abolished the induction of COX-2 in paw oedema but not in hyperalgesia." | 1.30 | Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. ( Chan, CC; Cirino, M; Denis, D; Gordon, R; Metters, KM; Nantel, F; Northey, A, 1999) |
| "1." | 1.29 | Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. ( Allchorne, A; Poole, S; Safieh-Garabedian, B; Winter, J; Woolf, CJ, 1995) |
| " The lower dosage of 4 mg was effective throughout and there was little to be gained by increasing the dose as further reduction of granuloma size was not obtained." | 1.29 | OM-89 modulation of chronic inflammation: relevance to clinical use. ( Gowland, G; Moore, AR; Willis, D; Willoughby, DA, 1995) |
| "Pain was induced by intraplantar injection of carrageenan (3 mg) into the hind paw of rats." | 1.29 | Antinociceptive properties of protein C in a model of inflammatory hyperalgesia in rats. ( Pichler, L; Schramm, W; Schwarz, HP; Ulrich, W; Varadi, K, 1995) |
| "Only avarol was able to inhibit human recombinant synovial phospholipase A2 activity with an IC50 = 158 microM, and thus this compound showed a potency higher than that of mepacrine." | 1.29 | Avarol and avarone, two new anti-inflammatory agents of marine origin. ( Alcaraz, MJ; Bustos, G; De Rosa, S; Ferrándiz, ML; Payá, M; Sanz, MJ, 1994) |
| "Oral treatment with prednisolone and cyclosporin A of zymosan-challenged animals showed a dose-dependent reduction of IL-1 beta concentrations, but no effect of indomethacin." | 1.29 | Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. II. Identification of (tissue) macrophages as the IL-1 producing cells and the effect of anti-inflammatory drugs. ( Chaplin, D; Dawson, J; Geiger, T; Kunz, S; Nguyen, H; Rordorf-Adam, C; Towbin, H; Vosbeck, K; Zingel, O, 1993) |
| "Bradykinin-induced hyperalgesia was abolished by HOE 140 and by treatment of the paws with anti-TNF-alpha antisera." | 1.29 | Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia. ( Cunha, FQ; Ferreira, SH; Lorenzetti, BB; Poole, S, 1993) |
| "Treatment with ibuprofen during induced inflammation significantly reduced LEA and increased red blood cell velocity." | 1.29 | Effects of nonsteroidal anti-inflammatory drugs on microvascular dynamics. ( House, SD; Slater, C, 1993) |
| "In another group, the hyperalgesia was removed almost completely for at least 24 hours by one dose of laser irradiation, which was given 3 hours after the carrageenin injection, whereas the edema was not inhibited." | 1.29 | Analgesic effect of Ga-Al-As diode laser irradiation on hyperalgesia in carrageenin-induced inflammation. ( Haruki, E; Honmura, A; Ishii, A; Obata, J; Yanase, M, 1993) |
| " These results suggested that the bioavailability of IND was increased by olive oil, fatty acid, and tristearin as absorbefacient agents." | 1.29 | Pharmacological and pharmaceutical properties of freeze-dried formulations of egg albumin, indomethacin, olive oil, or fatty acids. ( Kakegawa, H; Matsumoto, H; Miyataka, H; Satoh, T; Tsuji, Y, 1993) |
| "Indomethacin was more potent than prednisolone against PGE2 (ID50 of< 0." | 1.29 | Differential effects of prednisolone and indomethacin on zymosan-induced inflammation in a modified murine tissue-chamber model. ( Dawson, J; Nguyen, H; Oluyomi, AO; Towbin, H; Vosbeck, K, 1995) |
| "LPS induced thermal and mechanical hyperalgesia which was reversed by i." | 1.29 | Development of hyperthermia and hyperalgesia following intracerebroventricular administration of endotoxin in the rat: effect of kinin B1 and B2 receptor antagonists. ( Dray, A; Perkins, M; Walker, K, 1996) |
| " In dose-response experiments, down-regulation by TNF-alpha was significant at concentrations as low as 0." | 1.28 | Proinflammatory cytokines tumor necrosis factor-alpha and IL-6, but not IL-1, down-regulate the osteocalcin gene promoter. ( Li, YP; Stashenko, P, 1992) |
| "The edema was of a transient nature." | 1.28 | Differences in proinflammatory activity of several immunomodulatory derivatives of muramyl dipeptide (MDP) with special reference to the mechanism of the MDP effects. ( Zídek, Z, 1992) |
| "6MNA, the active metabolite of the non-acidic anti-inflammatory drug nabumetone, was investigated using intravenous administration for effects on (a) carrageenan paw oedema and gastric irritancy compared to either oral nabumetone or both oral and intravenous indomethacin when given acutely and (b) gastrointestinal irritancy when given in repeat dosing studies." | 1.28 | Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid): comparison with indomethacin. ( Blower, PR; Gentry, C; Kelvin, AS; Melarange, R; Neil, C; O'Connell, C; Toseland, CD, 1992) |
| "Inflammation was induced by injection of CMC as a non-specific irritant, lipopolysaccharide (LPS) as an activator of macrophages, and methylated bovine serum albumin (m-BSA) as an inducer of delayed type hypersensitivity." | 1.28 | Comparative studies on inflammatory reactions induced by non-immunological and immunological stimuli in an air pouch and in a carboxymethyl cellulose (CMC)-induced inflammatory pouch. ( Isaji, M; Naito, J, 1992) |
| " Chronic administration of the nonsteroidal anti-inflammatory drug indomethacin decreased the levels of IL-6 by 75% to 80%." | 1.28 | Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: inhibition by indomethacin. ( Arzadon, GK; Shacter, E; Williams, J, 1992) |
| "Pretreatment with indomethacin prevented the leakage of fluorescein into the anterior chamber up to 2 hrs after intracameral injection of lens proteins." | 1.28 | Prevention of lens protein-induced ocular inflammation with cyclooxygenase and lipoxygenase inhibitors. ( Chang, MS; Chiou, GC, 1989) |
| "With indomethacin the swelling was somewhat reduced, but there was no consistent difference to placebo in the pain and limping assessments." | 1.28 | Effects of phenylbutazone and indomethacin on the post-operative course following experimental orthopaedic surgery in dogs. ( Løkken, P; Mbugua, SW; Skoglund, LA, 1989) |
| "Indomethacin was found to eliminate this effect." | 1.27 | Haptoglobin and lipoperoxides in rabbit plasma under turpentine- and endotoxin-induced inflammation. ( Dobryszycka, W; Krawczyk, E; Przysiecki, BR; Rudkowska, B, 1984) |
| "Indomethacin was elected as the reference drug." | 1.27 | [Comparative study of platelet anti-aggregation effect of several anti-inflammatory agents]. ( Kunz, S; Migne, J; Santonja, R, 1983) |
| "Aspirin-when tested-was less potent than fenflumizole and indomethacin." | 1.27 | Fenflumizole: interactions with the arachidonic acid cascade. ( Corell, T; Hasselmann, G; Splawinski, J; Wojtaszek, B, 1983) |
| "Flurbiprofen was less effective than indomethacin in the immediate hypersensitivity reaction (IHR) model." | 1.27 | In vivo effects of indomethacin and flurbiprofen on the locomotion of neutrophils elicited by immune and non-immune inflammation in the rat. ( Giroud, JP; Hakim, J; Perianin, A; Roch-Arveiller, M, 1984) |
| "Treatment with androstenedione, which was reported to be inactive in the hepatoma tissue culture cells, did not interfere with the inhibitory effect of dexamethasone at all." | 1.27 | Mechanisms of anti-inflammatory action of dexamethasone: blockade by hydrocortisone mesylate and actinomycin D of the inhibitory effect of dexamethasone on leukocyte infiltration in inflammatory sites. ( Kurihara, A; Ojima, F; Tsurufuji, S, 1984) |
| "Inflammation was induced in the six-day air pouch either with the non-immune irritant carrageenan or the immune irritant Bordetella pertussis." | 1.27 | The effect of anti-inflammatory and rheumatoid disease modifying drugs on prolonged immune and non-immune inflammation in the six-day air pouch of rats. ( Al-Duaij, AY; Sedgwick, AD; Willoughby, DA, 1986) |
| "Indomethacin treatment elevated levels of peptido-LTs, reduced PGE2 levels and inhibited writhing." | 1.27 | Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2. ( Beaver, TH; Borgeat, P; Doherty, NS; Poubelle, P; Schrader, NL; Westrich, GL, 1985) |
| " Nafazatrom (Bayer 6575), quercetin and NDGA, which inhibit LPO activity in vitro, were inactive against all parameters when dosed at 100 mg per kg p." | 1.27 | Leukocyte recruitment in the subcutaneous sponge implant model of acute inflammation in the rat is not mediated by leukotriene B1. ( Aked, D; Foster, SJ; Howarth, A; McCormick, ME, 1986) |
| "Indomethacin promotes the establishment of a good filtration bleb that yields on a lasting ocular hypotonia, thus improving the results." | 1.27 | [Preliminary study on the effect of 1% indomethacin eyedrops in surgery of glaucoma]. ( Chachia, N; Romdane, K, 1988) |
| "Indomethacin failed to inhibit the release of BK." | 1.27 | Release of inflammatory mediators by noxious stimuli; effect of neurotropin on the release. ( Fukuhara, K; Inoki, R; Namimatsu, A; Ohara, H; Saito, K; Yago, H; Yoneda, R, 1988) |
| "Indomethacin was slowly cleared from the peritoneal compartment after intraperitoneal administration." | 1.27 | The cellular association of sodium salicylate and indomethacin in peritoneal fluid of ascites bearing mice. ( Huisman, JA; Raghoebar, M; van den Berg, WB; van Ginneken, CA, 1987) |
| "Pleurisy was induced by intrapleural injection of 1 ug of AGEPC into rats." | 1.27 | Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. ( Hayashi, M; Oh, S; Yamaki, K, 1986) |
| "025-16 micrograms/paw) were followed by a bell-shaped dose-response curve for oedema." | 1.27 | Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat. ( Castro, HC; Cordeiro, RS; Lima, MC; Martins, MA; Neto, F; Silva, PM; Vargaftig, BB, 1987) |
| "Pretreatment with promethazine, phenylbutazone, methysergide and indomethacin resulted in a decrease in foot oedema." | 1.27 | Turpentine-induced acute inflammatory response in Gallus gallus: oedema, vascular permeability and effects of non-steroidal anti-inflammatory drugs. ( Böhm, GM; Ito, NM, 1986) |
| "After inflammation was controlled by treatment with a mixture of Clerodendron inerme flavonoidal glycosides and indomethacin, rat liver mitochondria showed (i) an increase in 45Ca2+ uptake and, (ii) an increase in mitochondrial in vivo protein synthesis." | 1.27 | The role of mitochondrial calcium transport during inflammation and the effect of anti-inflammatory drugs. ( Sadique, J; Somasundaram, S, 1986) |
| "Indomethacin treatment was also ineffective." | 1.27 | Pharmacological analysis of the vascular permeability response in the anaphylactic phase of allergic inflammation in rats. ( Hirasawa, N; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1985) |
| " Dose-response experiments performed with 2 to 90 per cent (v/v) zymosan-activated plasma showed a direct correlation between the rate of neutrophil influx and the degree of vascular permeability in blood flow." | 1.26 | Vascular responses during acute neutrophilic inflammation. Their relationship to in vivo neutrophil emigration. ( Issekutz, AC, 1981) |
| "Indomethacin and ASA were also administered locally intradermally (id) into skin sites together with the E." | 1.26 | The effect of nonsteroidal anti-inflammatory agents on E. coli-induced inflammation. ( Bhimji, S; Issekutz, AC, 1982) |
| "This inflammation was induced on the back of rats by subcutaneous injection with air and carrageenin solution." | 1.26 | Comparative study between steroidal and nonsteroidal anti-inflammatory drugs on the mode of their actions on vascular permeability in rat carrageenin-air-pouch inflammation. ( Hashimoto, M; Ohuchi, K; Sato, H; Sugio, K; Tsurufuji, S, 1980) |
| "It is mainly the secondary phase of adjuvant arthritis which cannot be inhibited by treatment with several proteins." | 1.26 | The modulation of inflammation by the acute phase reaction in adjuvant arthritis in rats. ( Bekemeier, H; Hirschelmann, R; Schade, R, 1981) |
| " From these observations it is concluded that a specific pharmacokinetic behaviour of acidic NSAID leading to high concentrations in inflamed tissue is a decisive aspect of their anti-inflammatory action." | 1.26 | Inhibition of prostaglandin synthesis in vivo by nonsteroid anti-inflammatory drugs: evidence for the importance of pharmacokinetics. ( Brune, K; Glatt, M; Graf, P, 1976) |
| "Circular burns were inflicted on anaesthetized animals which were killed 30 min, 2 h or 4 h after burning." | 1.26 | On the enzymatic response to injury and its mediators. ( Nieminen, L; Raekallio, J, 1979) |
| "Granulocytopenia was found to have no effect." | 1.26 | Platelet aggregability in microvascular haemostasis and the effect of local inflammation. ( Arfors, KE; Bergqvist, D, 1978) |
| "Pre-treatment with indomethacin (2 mg/kg/i." | 1.26 | Relationship between oedema and plasma exudation in rat paw carrageenin inflammation. ( Ferreira, SH; Zanin, MT, 1978) |
| " The very shallow dose-response curves for flurbiprofen compared with acetylsalicylic acid, especially in the mouse and the rat test systems, are not due to an unreliable or abnormal absorption, which suggests that in these species the mode of action of flurbiprofen is not identical with that of acetylsalicylic acid." | 1.25 | Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent. ( Adams, SS; McCullough, KF; Nicholson, JS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 331 (39.13) | 18.7374 |
| 1990's | 139 (16.43) | 18.2507 |
| 2000's | 166 (19.62) | 29.6817 |
| 2010's | 159 (18.79) | 24.3611 |
| 2020's | 51 (6.03) | 2.80 |
| Authors | Studies |
|---|---|
| Cohen, N | 1 |
| Banner, BL | 1 |
| Lopresti, RJ | 1 |
| Walsh, DA | 2 |
| Moran, HW | 1 |
| Shamblee, DA | 1 |
| Welstead, WJ | 1 |
| Nolan, JC | 1 |
| Sancilio, LF | 1 |
| Graff, G | 1 |
| Muchowski, JM | 2 |
| Galeazzi, E | 1 |
| Greenhouse, R | 1 |
| Guzmán, A | 1 |
| Peréz, V | 1 |
| Ackerman, N | 2 |
| Ballaron, SA | 1 |
| Rovito, JR | 1 |
| Tomolonis, AJ | 1 |
| Young, JM | 1 |
| Cooper, GF | 1 |
| Halpern, O | 1 |
| Koehler, R | 1 |
| Kluge, AF | 1 |
| Simon, RL | 1 |
| Unger, SH | 1 |
| Van Horn, AR | 1 |
| Wren, DL | 1 |
| Ackrell, J | 1 |
| Terada, A | 1 |
| Naruto, S | 1 |
| Wachi, K | 1 |
| Tanaka, S | 1 |
| Iizuka, Y | 4 |
| Misaka, E | 1 |
| Silván, AM | 1 |
| Abad, MJ | 1 |
| Bermejo, P | 1 |
| Sollhuber, M | 1 |
| Villar, A | 1 |
| Huang, FC | 1 |
| Chan, WK | 1 |
| Moriarty, KJ | 1 |
| Zhang, DC | 1 |
| Chang, MN | 1 |
| He, W | 1 |
| Yu, KT | 1 |
| Zilberstein, A | 1 |
| Feixas, J | 1 |
| Jiménez, JM | 1 |
| Godessart, N | 1 |
| Puig, C | 1 |
| Soca, L | 1 |
| Crespo, MI | 1 |
| Almansa, C | 1 |
| Alfón, J | 1 |
| de Arriba, AF | 1 |
| Cavalcanti, FL | 1 |
| Escamilla, I | 1 |
| Gómez, LA | 2 |
| Miralles, A | 1 |
| Soliva, R | 1 |
| Bartrolí, J | 1 |
| Carceller, E | 1 |
| Merlos, M | 1 |
| García-Rafanell, J | 2 |
| Kontogiorgis, CA | 1 |
| Hadjipavlou-Litina, DJ | 1 |
| Hata, AN | 1 |
| Lybrand, TP | 1 |
| Breyer, RM | 1 |
| Doulgkeris, CM | 1 |
| Galanakis, D | 1 |
| Kourounakis, AP | 1 |
| Tsiakitzis, KC | 1 |
| Gavalas, AM | 1 |
| Eleftheriou, PT | 1 |
| Victoratos, P | 1 |
| Rekka, EA | 1 |
| Kourounakis, PN | 1 |
| Di Braccio, M | 1 |
| Grossi, G | 1 |
| Roma, G | 1 |
| Piras, D | 1 |
| Mattioli, F | 1 |
| Gosmar, M | 1 |
| Epifano, F | 3 |
| Genovese, S | 2 |
| Sosa, S | 3 |
| Tubaro, A | 3 |
| Curini, M | 3 |
| Sharma, M | 1 |
| Ray, SM | 1 |
| Kalkhambkar, RG | 1 |
| Kulkarni, GM | 1 |
| Kamanavalli, CM | 1 |
| Premkumar, N | 1 |
| Asdaq, SM | 1 |
| Sun, CM | 1 |
| Bhati, SK | 1 |
| Kumar, A | 3 |
| Abdel-Hafez, ShH | 1 |
| Girgis, AS | 1 |
| London, C | 1 |
| Hoyt, SB | 1 |
| Parsons, WH | 1 |
| Williams, BS | 1 |
| Warren, VA | 1 |
| Tschirret-Guth, R | 1 |
| Smith, MM | 2 |
| Priest, BT | 1 |
| McGowan, E | 1 |
| Martin, WJ | 1 |
| Lyons, KA | 1 |
| Li, X | 4 |
| Karanam, BV | 1 |
| Jochnowitz, N | 1 |
| Garcia, ML | 1 |
| Felix, JP | 1 |
| Dean, B | 1 |
| Abbadie, C | 1 |
| Kaczorowski, GJ | 1 |
| Duffy, JL | 1 |
| Magrioti, V | 1 |
| Naxakis, G | 1 |
| Hadjipavlou-Litina, D | 5 |
| Makriyannis, A | 1 |
| Kokotos, G | 1 |
| Koeberle, A | 1 |
| Zettl, H | 1 |
| Greiner, C | 1 |
| Wurglics, M | 1 |
| Schubert-Zsilavecz, M | 1 |
| Werz, O | 1 |
| Chikhale, RV | 1 |
| Bhole, RP | 1 |
| Khedekar, PB | 1 |
| Bhusari, KP | 1 |
| Paulino, N | 1 |
| Rodrigues, NC | 1 |
| Pardi, PC | 1 |
| Suárez, JA | 1 |
| dos Santos, RP | 1 |
| Scremin, A | 1 |
| Vogel, C | 1 |
| Feist, H | 1 |
| Michalik, D | 1 |
| Vasilevsky, SF | 1 |
| Govdi, AI | 1 |
| Shults, EE | 1 |
| Shakirov, MM | 1 |
| Sorokina, IV | 1 |
| Tolstikova, TG | 1 |
| Baev, DS | 1 |
| Tolstikov, GA | 1 |
| Alabugin, IV | 1 |
| Gökçe, M | 1 |
| Utku, S | 1 |
| Küpeli, E | 2 |
| Magoulas, GE | 1 |
| Krokidis, M | 1 |
| Papaioannou, D | 3 |
| Khan, KM | 1 |
| Ambreen, N | 1 |
| Mughal, UR | 1 |
| Jalil, S | 1 |
| Perveen, S | 1 |
| Choudhary, MI | 1 |
| Bi, W | 1 |
| Bi, Y | 1 |
| Xue, P | 1 |
| Zhang, Y | 8 |
| Gao, X | 1 |
| Wang, Z | 2 |
| Li, M | 1 |
| Baudy-Floc'h, M | 1 |
| Ngerebara, N | 1 |
| Gibson, KM | 1 |
| Bi, L | 1 |
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 2 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Pontiki, E | 1 |
| Litinas, K | 1 |
| Nicolotti, O | 1 |
| Carotti, A | 1 |
| Marcotullio, MC | 2 |
| Ma, L | 5 |
| Xie, C | 1 |
| Ma, Y | 1 |
| Liu, J | 1 |
| Xiang, M | 2 |
| Ye, X | 1 |
| Zheng, H | 1 |
| Chen, Z | 2 |
| Xu, Q | 2 |
| Chen, T | 2 |
| Chen, J | 5 |
| Yang, J | 1 |
| Qiu, N | 1 |
| Wang, G | 1 |
| Liang, X | 2 |
| Peng, A | 2 |
| Yang, S | 1 |
| Wei, Y | 3 |
| Chen, L | 3 |
| Hernández, P | 1 |
| Cabrera, M | 1 |
| Lavaggi, ML | 1 |
| Celano, L | 1 |
| Tiscornia, I | 1 |
| Rodrigues da Costa, T | 1 |
| Thomson, L | 1 |
| Bollati-Fogolín, M | 1 |
| Miranda, AL | 1 |
| Lima, LM | 3 |
| Barreiro, EJ | 2 |
| González, M | 1 |
| Cerecetto, H | 1 |
| Mizokami, SS | 1 |
| Arakawa, NS | 1 |
| Ambrosio, SR | 1 |
| Zarpelon, AC | 1 |
| Casagrande, R | 2 |
| Cunha, TM | 3 |
| Ferreira, SH | 16 |
| Cunha, FQ | 6 |
| Verri, WA | 4 |
| Bariamis, SE | 1 |
| Marin, M | 1 |
| Athanassopoulos, CM | 2 |
| Kontogiorgis, C | 1 |
| Tsimali, Z | 1 |
| Sindona, G | 1 |
| Romeo, G | 2 |
| Avgoustakis, K | 1 |
| Borghi, SM | 1 |
| Carvalho, TT | 1 |
| Staurengo-Ferrari, L | 1 |
| Hohmann, MS | 1 |
| Pinge-Filho, P | 1 |
| Rajagopalan, P | 1 |
| Tracey, H | 1 |
| Bandyopadhyaya, A | 1 |
| Veeraraghavan, S | 1 |
| Rajagopalan, DR | 1 |
| Salvemini, D | 2 |
| McPhee, I | 1 |
| Viswanadha, S | 1 |
| Rajagopalan, R | 1 |
| Pei, H | 1 |
| Lei, L | 3 |
| He, L | 3 |
| Ye, H | 1 |
| Sarigol, D | 1 |
| Uzgoren-Baran, A | 1 |
| Tel, BC | 1 |
| Somuncuoglu, EI | 1 |
| Kazkayasi, I | 1 |
| Ozadali-Sari, K | 1 |
| Unsal-Tan, O | 1 |
| Okay, G | 1 |
| Ertan, M | 1 |
| Tozkoparan, B | 1 |
| He, J | 1 |
| Wei, Z | 1 |
| Peng, F | 1 |
| Shao, M | 1 |
| Tang, M | 1 |
| Wu, Y | 3 |
| Srinivas, V | 1 |
| Mohan, CD | 1 |
| Baburajeev, CP | 1 |
| Rangappa, S | 1 |
| Jagadish, S | 1 |
| Fuchs, JE | 1 |
| Sukhorukov, AY | 1 |
| Mason, DJ | 1 |
| Sharath Kumar, KS | 1 |
| Madegowda, M | 1 |
| Bender, A | 1 |
| Rangappa, KS | 1 |
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Singh, G | 3 |
| Bhatti, R | 3 |
| Gupta, M | 1 |
| Sharma, A | 1 |
| Singh Ishar, MP | 1 |
| Singh, P | 2 |
| Kaur, S | 2 |
| Kumari, P | 2 |
| Kaur, B | 1 |
| Kaur, M | 1 |
| Bhatti, M | 1 |
| Marín-Ocampo, L | 1 |
| Veloza, LA | 1 |
| Abonia, R | 1 |
| Sepúlveda-Arias, JC | 1 |
| AlFadly, ED | 1 |
| Elzahhar, PA | 1 |
| Tramarin, A | 1 |
| Elkazaz, S | 1 |
| Shaltout, H | 1 |
| Abu-Serie, MM | 1 |
| Janockova, J | 1 |
| Soukup, O | 1 |
| Ghareeb, DA | 1 |
| El-Yazbi, AF | 1 |
| Rafeh, RW | 1 |
| Bakkar, NZ | 1 |
| Kobeissy, F | 1 |
| Iriepa, I | 1 |
| Moraleda, I | 1 |
| Saudi, MNS | 1 |
| Bartolini, M | 1 |
| Belal, ASF | 1 |
| Ali, EMH | 1 |
| Abdel-Maksoud, MS | 1 |
| Oh, CH | 1 |
| Kaur, J | 1 |
| Zheng, XJ | 1 |
| Li, CS | 1 |
| Cui, MY | 1 |
| Song, ZW | 1 |
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| Liang, CW | 1 |
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| Zhang, TY | 1 |
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| Rapa, SF | 1 |
| Asadpour, R | 1 |
| Schwaiger, S | 1 |
| Troppmair, J | 1 |
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| Li, Z | 6 |
| Tan, C | 1 |
| Zheng, Y | 2 |
| Zhang, YL | 1 |
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| Ji, YR | 1 |
| Guo, YH | 1 |
| Huang, C | 2 |
| Sun, GP | 1 |
| Li, J | 3 |
| Huang, Y | 1 |
| Huang, W | 1 |
| Yang, G | 2 |
| Wang, R | 3 |
| Neha, K | 1 |
| Wakode, S | 1 |
| Zhu, G | 1 |
| Zhao, H | 1 |
| Zhang, X | 4 |
| Zhou, W | 5 |
| Wang, C | 2 |
| Liu, Z | 2 |
| Gou, S | 1 |
| Ma, N | 1 |
| Sun, Y | 1 |
| Yi, J | 1 |
| Zhou, L | 1 |
| Cai, S | 1 |
| Fagundes, FL | 1 |
| Pereira, QC | 1 |
| Zarricueta, ML | 1 |
| Dos Santos, RC | 1 |
| Nascimento, WM | 1 |
| Oliveira, JRS | 1 |
| Cunha, RX | 1 |
| Gambôa, DSR | 1 |
| Silva, APS | 1 |
| Lima, VLM | 1 |
| Martínez-Martínez, MDC | 1 |
| Parra-Flores, LI | 1 |
| Baeza-Flores, GDC | 1 |
| Torres-López, JE | 1 |
| Samer, A | 1 |
| Toumi, R | 1 |
| Soufli, I | 1 |
| Touil-Boukoffa, C | 1 |
| Andleeb, F | 1 |
| Asif, M | 3 |
| Yaseen, HS | 3 |
| Ricci, F | 1 |
| Racaniello, GF | 1 |
| Lopedota, A | 1 |
| Laquintana, V | 1 |
| Arduino, I | 1 |
| Lopalco, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Three-way Cross-over Comparative Pharmacokinetic Study of Resveratrol Comprising Products in Fasting Healthy Subjects[NCT01747252] | 15 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial[NCT04219358] | Phase 1 | 49 participants (Actual) | Interventional | 2019-03-23 | Terminated (stopped due to Study terminated because of COVID19 pandemics.) | ||
| Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty: A Pilot Randomized Control Trial[NCT02406131] | 40 participants (Anticipated) | Interventional | 2018-04-30 | Suspended (stopped due to logistic issues - no available scans for participants at the moment need to postponed starting dates) | |||
| Dubbelblind Crossover Study for Validation of New Tests for Gastrointestinal (GI) Permeability[NCT00943345] | Early Phase 1 | 34 participants (Anticipated) | Interventional | 2009-09-30 | Enrolling by invitation | ||
| Gut Permeability in Very Low Birth Weight Infants[NCT01756040] | Phase 1 | 211 participants (Actual) | Interventional | 2013-02-01 | Completed | ||
| A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation in High Risk Primary Prevention (Patients With Metabolic Syndrome)[NCT00272311] | Phase 4 | 70 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| A Randomized, Double-Blind Trial to Test Higher- Versus Lower-Doses of Aspirin on Inflammatory Markers and Platelet Biomarkers and Nitric Oxide Formation & Endothelial Function in Secondary Prevention (Pts w/Chronic Stable Coronary Disease)[NCT00272337] | Phase 4 | 37 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| Peripheral Markers of Inflammation in Patients With Alzheimer's Disease Compared to Cognitively Normal Elderly[NCT02472899] | 115 participants (Actual) | Observational | 2007-02-28 | Completed | |||
| Cytokine Responses to Acute Inflammation in the Oral Surgery Model[NCT00006175] | 160 participants | Observational | 2000-08-31 | Completed | |||
| Omega EVAR: Use of Fish Oil to Reduce Inflammation During Endovascular Abdominal Aortic Repair.[NCT03208920] | 2 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| Randomised Controlled Trial On The Effects Of Parenteral Fish Oil Emulsion In Patients With Severe Acute Pancreatitis[NCT01745861] | Phase 2 | 44 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of days breast milk feeding prior to La/Rh measurement between d7-10 days of age. (NCT01756040)
Timeframe: 7-10 days postnatal
| Intervention | days (Mean) |
|---|---|
| Low Intestinal Permeability (IP) Group | 7.02 |
| High IP Group | 6.1 |
Intestinal Permeability measured by urinary excretion of orally administered lactulose/rhamnose (La/Rh ratio) (NCT01756040)
Timeframe: 7-10 days postnatal
| Intervention | ratio (Mean) |
|---|---|
| Gestational Age <29 wk | 0.0731 |
| Gestational Age ≥29 Weeks | 0.0720 |
Frequency of ≥ Stage 2 Necrotizing enterocolitis (NCT01756040)
Timeframe: 0-28 days postnatal
| Intervention | Participants (Count of Participants) |
|---|---|
| Low Intestinal Permeability (IP) Group | 0 |
| High IP Group | 0 |
Percent of participants with antibiotic exposure prior to La/Rh measurement (NCT01756040)
Timeframe: 7-10 days postnatal
| Intervention | Participants (Count of Participants) |
|---|---|
| Low Intestinal Permeability (IP) Group | 79 |
| High IP Group | 67 |
Postnatal age when all nutrition is provided by enteral feeds (NCT01756040)
Timeframe: 0-100 days postnatal
| Intervention | days (Mean) |
|---|---|
| Low Intestinal Permeability (IP) Group | 11.46 |
| High IP Group | 22.02 |
Stool alpha-1 antitrypsin concentrations (NCT01756040)
Timeframe: 7-10 days postnatal
| Intervention | µg/ml (Mean) |
|---|---|
| Low Intestinal Permeability (IP) Group | 359.5 |
| High IP Group | 1285.3 |
Relative abundance (%) Clostridiales species (NCT01756040)
Timeframe: 7-10 days postnatal
| Intervention | percentage of Clostridiales in stool (Median) |
|---|---|
| Low Intestinal Permeability (IP) Group | 6.52 |
| High IP Group | 0.07 |
Changes in Heme oxygenase (HO-1) a downstream target of nitric oxide (NO) formation. (NCT00272311)
Timeframe: Baseline to 3 Months (90-97 days)
| Intervention | ng/mL (Mean) |
|---|---|
| Arm 1 of 5 Randomized Treatment Arms | 27.6 |
| Arm 2 of 5 Randomized Treatment Arms | 27.0 |
| Arm 3 of 5 Randomized Treatment Arms | 31.4 |
| Arm 4 of 5 Randomized Treatment Arms | 25.7 |
| Arm 5 of 5 Randomized Treatment Arms | 28.3 |
Heme oxygenase a downstream target of nitric oxide formation (NCT00272337)
Timeframe: Baseline to 3 Months (90-97 days)
| Intervention | ng/mL (Mean) |
|---|---|
| 1 of 5 Randomized Treatment Arms | 10.0 |
| 2 of 5 Randomized Treatment Arms | 11.2 |
| 3 of 5 Randomized Treatment Arms | 10.0 |
| 4 of 5 Randomized Treatment Arms | 11.0 |
| 5 of 5 Randomized Treatment Arms | 9.6 |
31 reviews available for indomethacin and Innate Inflammatory Response
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Anti-inflammatory activity of triazine derivatives: A systematic review.
Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Structure-Activity Relationship; Triazines | 2019 |
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemistry, Ph | 2019 |
Contemporary advances of cyclic molecules proposed for inflammation.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Humans; Inflammation; Molecular | 2021 |
Methanolic extract of Ephedra ciliata promotes wound healing and arrests inflammatory cascade in vivo through downregulation of TNF-α.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antioxidants; Aspergillus niger; Candida a | 2020 |
NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis.
Topics: Animals; Anti-Inflammatory Agents; Gene Expression Regulation; Glyburide; Humans; Indomethacin; Infl | 2020 |
Benefit-risk of corticosteroids in acute gout patients: An updated meta-analysis and economic evaluation.
Topics: Adrenal Cortex Hormones; Cost-Benefit Analysis; Gout; Humans; Indomethacin; Inflammation | 2017 |
Role of NO and other vascular mediators in the etiopathogenesis of necrotizing enterocolitis.
Topics: Age of Onset; Animals; Arginine; Catecholamines; Disease Models, Animal; Dogs; Endothelins; Enteroco | 2019 |
Role of indomethacin in acute pain and inflammation management: a review of the literature.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Inflammation; Ketorolac; | 2014 |
Phytochemicals enhance antioxidant enzyme expression to protect against NSAID-induced oxidative damage of the gastrointestinal mucosa.
Topics: Angiogenesis Inducing Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Aspi | 2017 |
Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Animals, Genetically Modified; Anti-Inflammator | 2005 |
Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Anti-Inflammatory Agents, Non-Steroidal; C-Reacti | 2006 |
Arachidonic acid metabolism and macrophage activation.
Topics: Animals; Arachidonic Acids; Ascitic Fluid; Epoprostenol; Guinea Pigs; Immunity, Cellular; Indomethac | 1983 |
Anti-inflammatory agents as inhibitors of prostaglandin synthesis in man.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Dru | 1981 |
Drug therapy: nonsteroidal antiinflammatory drugs (first of two parts).
Topics: Anti-Inflammatory Agents; Arthritis; Aspirin; Child; Drug Tolerance; Female; Gastric Mucosa; Gastrit | 1980 |
Prostaglandins, macrophages, and immunity.
Topics: Arachidonic Acids; Aspirin; Cell Division; Cell Separation; Epoprostenol; Immunity, Cellular; Indome | 1980 |
Nonsteroidal antiinflammatory drugs as inhibitors of periodontal disease progression.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Flurbiprofen; | 1993 |
Endogenous interleukin-10 in inflammatory disorders: regulatory roles and pharmacological modulation.
Topics: Animals; Humans; Indomethacin; Inflammation; Interleukin-10; Lipopolysaccharides; Methylprednisolone | 1996 |
Selective cyclooxygenase-2 inhibitors as potential therapeutic agents for inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2 | 1997 |
The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Cholesterol; Dietary Fats; Epoprostenol | 1979 |
Prostaglandins and the immune response.
Topics: Animals; Antibody Formation; B-Lymphocytes; Cyclic AMP; Cyclic GMP; Cytotoxicity Tests, Immunologic; | 1977 |
Nonsteroidal anti-inflammatory drugs: a review. New applications in hypersensitivity reactions of cattle and horses.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents; Arthritis; Ascariasis; Aspirin; Cattle; Cattle Disea | 1977 |
Indomethacin--a calcium antagonist.
Topics: Animals; Blood Vessels; Calcium; Endothelium; Glucuronidase; Granulocytes; In Vitro Techniques; Indo | 1977 |
[Effect of non-steroidal anti-inflammatory drugs on plasma protein binding of corticosterones (author's transl)].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Blo | 1978 |
Prostaglandins and other metabolites of arachidonic acid. An overview for the otolaryngologist.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; Blo | 1985 |
Prevention of cecitis in hamsters by certain prostaglandins.
Topics: Animals; Aspirin; Castor Oil; Cecal Diseases; Clindamycin; Cricetinae; Indomethacin; Inflammation; M | 1985 |
[Mechanism of action of non-steroid anti-inflammatory agents].
Topics: Acid-Base Equilibrium; Adenosine Triphosphatases; Anti-Inflammatory Agents; Ascorbic Acid; Autacoids | 1971 |
[Clinical use of non-steroid anti-inflammatory agents].
Topics: Animals; Anti-Inflammatory Agents; Antigen-Antibody Complex; Arthritis, Rheumatoid; Aspirin; Cell Mi | 1974 |
Inhibition of prostaglandin biosynthesis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cats; Cattle; Depression, Chemical; Dogs; Fa | 1974 |
[Considerations on the therapy of phlogoses with non-steroid anti-inflammatory drugs].
Topics: Animals; Anti-Inflammatory Agents; Fibrinolytic Agents; Humans; Indomethacin; Inflammation; Oxadiazo | 1968 |
[Non-steroidal anti-inflammatory drugs for eye diseases].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Child; Child, Preschool; Enzyme Therapy; Eye Diseases; | 1968 |
33 trials available for indomethacin and Innate Inflammatory Response
| Article | Year |
|---|---|
A novel red grape cells complex: health effects and bioavailability of natural resveratrol.
Topics: Adult; Animals; Biological Availability; Carrageenan; Cross-Over Studies; Edema; Humans; Indomethaci | 2014 |
Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Over Studies; Double-Blind Method; | 2015 |
Randomized Prospective Study of the Use of Anti-Inflammatory Drops After Selective Laser Trabeculoplasty.
Topics: Administration, Topical; Aged; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Female; Glauc | 2017 |
Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial.
Topics: Adolescent; Adult; Aged; Carbohydrates; Cross-Over Studies; Double-Blind Method; Female; Gas Chromat | 2013 |
Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial.
Topics: Adolescent; Adult; Aged; Carbohydrates; Cross-Over Studies; Double-Blind Method; Female; Gas Chromat | 2013 |
Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial.
Topics: Adolescent; Adult; Aged; Carbohydrates; Cross-Over Studies; Double-Blind Method; Female; Gas Chromat | 2013 |
Novel multi-sugar assay for site-specific gastrointestinal permeability analysis: a randomized controlled crossover trial.
Topics: Adolescent; Adult; Aged; Carbohydrates; Cross-Over Studies; Double-Blind Method; Female; Gas Chromat | 2013 |
Efficacy and safety of indomethacin 0.1% eye drops compared with ketorolac 0.5% eye drops in the management of ocular inflammation after cataract surgery.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Endophthalmitis; Female; Humans; | 2013 |
Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis.
Topics: Acetylcholine; Adult; Algorithms; Ascorbic Acid; Celecoxib; Cyclooxygenase 2; Endothelium, Vascular; | 2006 |
Pharmacological prevention of the deleterious effects of cardiopulmonary bypass.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Coagulation; C-Reactive Protein; Cardiac Surgical Pro | 2007 |
Nonsteroidal anti-inflammatory agents after argon laser trabeculoplasty. A trial with flurbiprofen and indomethacin.
Topics: Adult; Aged; Argon; Clinical Trials as Topic; Double-Blind Method; Eye Diseases; Female; Flurbiprofe | 1984 |
The developing bleb: effect of topical antiprostaglandins on the outcome of glaucoma fistulising surgery.
Topics: Adult; Aged; Conjunctivitis; Fistula; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Indomethacin; | 1983 |
Activity and tolerance of oxamethacin.
Topics: Anti-Inflammatory Agents; Arthritis; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; | 1982 |
General practitioners' evaluation of side-effects and efficacy of oxamethacin as compared with indomethacin.
Topics: Analysis of Variance; Capsules; Clinical Trials as Topic; Digestive System; Double-Blind Method; Fem | 1980 |
Benoxaprofen--dose-range studies using quantitative thermography.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzoxazoles; Clinical Trials as Topic; Dose-Respon | 1980 |
[Comparison of the therapeutic efficacy and tolerability of acemetacin and tolmetin (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Double-Blind Method; Female; Humans; In Vitro Techniques; Ind | 1980 |
Faecal calprotectin shedding after short-term treatment with non-steroidal anti-inflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Feces; Gastric Mucosa; Humans; I | 1996 |
Influence of severity of chronic inflammatory joint disease on the pharmacokinetics of indomethacin and etodolac.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Ar | 1996 |
[Efficacy and tolerability of a combination of indomethacin and gentamicin for preventing inflammation after cataract surgery].
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroida | 1996 |
[Double-blind study on 3 parallel groups of 2 formulations of 0.1% indomethacin and 0.1% diclofenac in preventing and controlling inflammation after cataract surgery].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclofenac; Double-Blind Method; | 1997 |
[Diclofenac in the treatment of inflammatory and degenerative diseases of the locomotor system].
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Drug Evaluation; Humans; Indomethacin; Inflammati | 1977 |
[Limitations of the isotopic evaluation of the effects of diftalone and indomethacin on inflammation induced with subcutaneous injection of microcrystals of monosodic urate].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Humans; Indomethacin; Inflammation | 1978 |
[Comparative study of the efficacy of diclofenac sodium and indomethacin in post-operative inflammation following varicose vein surgery].
Topics: Adult; Clinical Trials as Topic; Diclofenac; Humans; Indomethacin; Inflammation; Middle Aged; Phenyl | 1979 |
[Double-blind study on the anti-inflammatory effect of indomethacin after surgical removal of lower wisdom teeth].
Topics: Adult; Body Temperature; Clinical Trials as Topic; Double-Blind Method; Edema; Female; Humans; Indom | 1979 |
Inflammation in human skin induced by ultraviolet irradiation.
Topics: Adult; Erythema; Humans; Indomethacin; Inflammation; Periodicity; Prostaglandins F; Skin; Ultraviole | 1977 |
Flurbiprofen in rheumatoid arthritis therapy.
Topics: Animals; Arthritis, Rheumatoid; Female; Flurbiprofen; Humans; Indomethacin; Inflammation; Male; Prop | 1977 |
Indomethacin--aspirin interaction: a clinical appraisal.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Interactions; Humans; Indomethacin; I | 1975 |
Intravenous indomethacin prevents venipuncture inflammatory sequelae.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Inflammation; In | 1988 |
Pirprofen in postoperative course following cataract extraction: a controlled trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Clinical Trials as Topic; Double-Blind | 1985 |
Anti-inflammatory actions of indomethacin in the eye.
Topics: Animals; Clinical Trials as Topic; Eye Diseases; Hydrocortisone; Indomethacin; Inflammation; Rabbits | 1967 |
Pain relief with indomethacin in external otitis.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Edema; Female; Humans; Indomethacin; Inflammation | 1972 |
Indomethacin for soft-tissue injuries. A double-blind study in football players.
Topics: Analgesics; Athletic Injuries; Humans; Indomethacin; Inflammation; Male; Pain; Time Factors | 1973 |
Effect of anti-inflammatory drug therapy on clearance of 133-Xe from knee joints of patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Indomethacin; Inflammation; Injections, Int | 1969 |
Indices of inflammatory activity. Relationship between isotope studies and clinical methods.
Topics: Adult; Anthropometry; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Fem | 1970 |
Antipyretic effect of indomethacin suppositories: A double-blind study.
Topics: Analgesics; Child; Child, Preschool; Fever; Humans; Indomethacin; Infant; Infant, Newborn; Infection | 1969 |
Effect of non-steroidal anti-inflammatory drugs on osteoarthritis of the knee. With special reference to PSP clearance as an indicator.
Topics: Aspirin; Humans; Indomethacin; Inflammation; Knee Joint; Osteoarthritis; Phenylbutazone; Physical Th | 1970 |
782 other studies available for indomethacin and Innate Inflammatory Response
| Article | Year |
|---|---|
Analgesic activity of novel spiro heterocycles. 2-Amino-7-oxa-3-thia-1-azaspiro[5,5]undec-1-enes and related compounds.
Topics: Analgesics; Animals; Female; Inflammation; Lethal Dose 50; Male; Mice; Quinones; Rats; Reaction Time | 1978 |
Antiinflammatory agents. 4. Syntheses and biological evaluation of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid.
Topics: Acetamides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzeneacetam | 1990 |
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-ca rboxyl ic acids and 1-methyl-4-(methylthio)-5-aroylpyrrole-2-acetic acids.
Topics: Acetates; Analgesia; Animals; Aspirin; Benzoquinones; Carboxylic Acids; Carrageenan; Chemical Phenom | 1989 |
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids. The 6-substituted compounds.
Topics: Analgesia; Animals; Carboxylic Acids; Chemical Phenomena; Chemistry; Inflammation; Magnetic Resonanc | 1987 |
Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Female; Fever; Ibuprofen; Indomethacin; Inflamma | 1984 |
Antiinflammatory activity of coumarins from Santolina oblongifolia.
Topics: Animals; Anti-Inflammatory Agents; Calcimycin; Carrageenan; Chromatography, Thin Layer; Coumarins; D | 1996 |
Novel cytokine release inhibitors. Part I: Triterpenes.
Topics: Animals; Cytokines; Humans; In Vitro Techniques; Inflammation; Molecular Structure; Rats; Triterpene | 1998 |
Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2001 |
Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Binding Sites | 2003 |
Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Azo Compounds; Carrageenan; Coumarin | 2004 |
Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Cell Line; Cell Mov | 2005 |
Synthesis and pharmacochemical study of novel polyfunctional molecules combining anti-inflammatory, antioxidant, and hypocholesterolemic properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antioxidants; Arthritis; | 2006 |
1,8-Naphthyridines VI. Synthesis and anti-inflammatory activity of 5-(alkylamino)-N,N-diethyl[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides with a new substitution pattern on the triazole ring.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Drug Design; Edema; Inflammation; Male; Naphthyridin | 2008 |
Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives.
Topics: Animals; Anti-Inflammatory Agents; Diterpenes; Esters; Inflammation; Magnetic Resonance Spectroscopy | 2007 |
Synthesis and biological evaluation of amide derivatives of (5,6-dimethoxy-2,3-dihydro-1H-inden-1-yl)acetic acid as anti-inflammatory agents with reduced gastrointestinal ulcerogenecity.
Topics: Acetates; Amides; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthri | 2008 |
Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins.
Topics: Analgesics; Animals; Aza Compounds; Bacteria; Coumarins; Drug Design; Fluorine; Fungi; Inflammation; | 2008 |
Synthesis of new substituted azetidinoyl and thiazolidinoyl-1,3,4-thiadiazino (6,5-b) indoles as promising anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Aza Compounds; Indoles; Inflammation; Mice; Molecular Structure; | 2008 |
Selenium containing heterocycles: synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivatives.
Topics: Analgesics; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bacteria; Drug Design; Fungi; | 2008 |
Facile synthesis of dithiatetraaza-macrocycles of potential anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aza Compounds; Carrageenan; Drug Discovery; Edema; | 2008 |
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Topics: Analgesics; Animals; Inflammation; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Pain; P | 2008 |
A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Cannabinoid Receptor Modula | 2008 |
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Topics: Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Cyclooxygenase 1; Cyclooxygenase 2; Drug | 2008 |
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper | 2009 |
Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
Topics: Analgesics; Animals; Anisoles; Anti-Inflammatory Agents; Cell Line; Cell Survival; Dinoprostone; Ede | 2009 |
Efficient synthesis of the first betulonic acid-acetylene hybrids and their hepatoprotective and anti-inflammatory activity.
Topics: Acetylene; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Edema; Enzymes | 2009 |
Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal)hydrazone derivatives.
Topics: Abdominal Pain; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Hydrazones; Inf | 2009 |
Syntheses and evaluation of the antioxidant activity of acitretin analogs with amide bond(s) in the polyene spacer.
Topics: Acitretin; Amides; Animals; Antioxidants; Edema; Electrons; Esters; Female; Glycine max; Heterocycli | 2010 |
3-Formylchromones: potential antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chromones; Cyclooxygenase Inhibitors; | 2010 |
Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Capillary Permeability; Free Radical | 2010 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.
Topics: Acrylates; Animals; Anti-Inflammatory Agents; Antioxidants; Binding Sites; Cyclooxygenase 1; Cycloox | 2011 |
Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2011 |
Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Benzylidene Compounds; Carrageenan; Cell | 2011 |
Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase Inhibitors; Drug Design; Fe | 2012 |
Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Administration, Oral; Animals; Asteraceae; Carbazoles; Cyclic GMP-Dependent Protein Kin | 2012 |
Syntheses and evaluation of the antioxidant activity of novel methoxypsoralen derivatives.
Topics: Anti-Inflammatory Agents; Antioxidants; Dose-Response Relationship, Drug; Furocoumarins; Glycine max | 2013 |
Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apigenin; Benzoquinones; Capsaicin; Carrageenan; Cyto | 2013 |
DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Carbolines; Chronic Disease; | 2014 |
Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases.
Topics: Animals; Benzylidene Compounds; Carrageenan; Cell Line; Dose-Response Relationship, Drug; Edema; Enz | 2015 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; D | 2015 |
Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Carrageenan; Cell Line; Inflammation; Lipopolysacchari | 2015 |
Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2.
Topics: Anti-Inflammatory Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Inflammation; Molec | 2015 |
Indolyl-isoxazolidines attenuate LPS-stimulated pro-inflammatory cytokines and increase survival in a mouse model of sepsis: Identification of potent lead.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Inflammation; Interleukin-6; | 2018 |
Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice.
Topics: Analgesics; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Drug D | 2018 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 In | 2019 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 In | 2020 |
Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Benzothiazoles; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Fr | 2020 |
Labdane-Type Diterpenes from the Aerial Parts of
Topics: Cells, Cultured; Diterpenes; Humans; Inflammation; Inflammation Mediators; Keratinocytes; Leonurus; | 2020 |
Novel piperazine-2,5-dione analogs bearing 1H-indole: Synthesis and biological effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Depression; Drug Discovery; In | 2020 |
Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dru | 2021 |
Design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents.
Topics: Alzheimer Disease; Animals; Cell Line; Diosgenin; Dose-Response Relationship, Drug; Drug Design; Inf | 2021 |
Design, synthesis and structure-activity relationship studies of 4-indole-2-arylaminopyrimidine derivatives as anti-inflammatory agents for acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cytokines; Dose-Resp | 2021 |
Hypoxia-Activated Prodrugs with Dual COX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carbonic Anhydrase Inhibitors; Ca | 2022 |
Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis.
Topics: Animals; Animals, Outbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apopt | 2022 |
Malvidin Protects against and Repairs Peptic Ulcers in Mice by Alleviating Oxidative Stress and Inflammation.
Topics: Acetic Acid; Animals; Anthocyanins; Antioxidants; Biomarkers; Cyclooxygenase 1; Disease Models, Anim | 2021 |
Evaluation of the treatment of fever, pain and inflammation with Indigofera suffruticosa Miller Leaves Aqueous Extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Fever; Indigofera; Indomethacin; Inflam | 2022 |
Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration.
Topics: Acetaminophen; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Dr | 2022 |
Cell-free probiotic supernatant (CFS) treatment alleviates indomethacin-induced enterocolopathy in BALB/c mice by down-modulating inflammatory response and oxidative stress: potential alternative targeted treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Indomethacin; Inflammation; Malo | 2022 |
Exploration of molecular mechanisms responsible for anti-inflammatory and anti-angiogenic attributes of methanolic extract of Viola betonicifolia.
Topics: Animals; Anti-Inflammatory Agents; Edema; Indomethacin; Inflammation; Methanol; Plant Extracts; Viol | 2022 |
Chitosan/sulfobutylether-β-cyclodextrin based nanoparticles coated with thiolated hyaluronic acid for indomethacin ophthalmic delivery.
Topics: beta-Cyclodextrins; Chitosan; Drug Carriers; Drug Delivery Systems; Humans; Hyaluronic Acid; Indomet | 2022 |
The combination of ciprofloxacin and indomethacin suppresses the level of inflammatory cytokines secreted by macrophages in vitro.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ciprofloxacin; Cytokines; Humans; Indometh | 2022 |
Ficus vogelii methanol leaf extract ameliorates inflammation and arthritis by modulating osmotic fragility in C57BL/6J mice.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Diclofenac; Edema; Ficus; G | 2021 |
Synthesis, Molecular Docking and ADME Prediction of 1H-indole/5- substituted Indole Derivatives as Potential Antioxidant and Anti- Inflammatory Agents.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cyclooxygenase 2; Edema; Indomethacin; | 2023 |
Programmed prodrug breaking the feedback regulation of P-selectin in plaque inflammation for atherosclerotic therapy.
Topics: Animals; Atherosclerosis; Endothelial Cells; Feedback; Heparin, Low-Molecular-Weight; Indomethacin; | 2022 |
Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colocasia; Cyclooxygenase 2; Cytokines; Dinoprostone | 2023 |
Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colocasia; Cyclooxygenase 2; Cytokines; Dinoprostone | 2023 |
Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colocasia; Cyclooxygenase 2; Cytokines; Dinoprostone | 2023 |
Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Colocasia; Cyclooxygenase 2; Cytokines; Dinoprostone | 2023 |
Honokiol, an inducer of sirtuin-3, protects against non-steroidal anti-inflammatory drug-induced gastric mucosal mitochondrial pathology, apoptosis and inflammatory tissue injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Gastric Mucosa; Indomethacin; Inflammat | 2023 |
Lafutidine Ameliorates Indomethacin-Induced Small Intestinal Damage in Rats by Modifying the Intestinal Mucosal Barrier, Inflammation, and Microbiota.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Inflammation; Intestinal Diseases; I | 2023 |
Indomethacin Prophylaxis Is Associated with Reduced Risk of Intraventricular Hemorrhage in Extremely Preterm Infants Born in the Context of Amniotic Infection Syndrome.
Topics: Cerebral Hemorrhage; Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant; Infant, Extrem | 2023 |
Flavonoid-Rich
Topics: Animals; Antioxidants; Flavonoids; Fruit; Glutathione; Indomethacin; Inflammation; NF-E2-Related Fac | 2023 |
The ratio of M1 to M2 microglia in the striatum determines the severity of L-Dopa-induced dyskinesias.
Topics: Animals; Anti-Inflammatory Agents; Antiparkinson Agents; Corpus Striatum; Dyskinesias; Indomethacin; | 2023 |
NSAIDs disrupt intestinal homeostasis by suppressing macroautophagy in intestinal epithelial cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Epithelial Cells; Gastrointestinal Diseases; Goble | 2019 |
Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-
Topics: Animals; Celecoxib; Cyclooxygenase 2; Gene Expression Regulation; Hesperidin; Humans; Hydrophobic an | 2019 |
Prostaglandin-E2 deficiency during late pregnancy and the associated increase in interleukin-1β derived from periaortic lymph nodes lead to abortion.
Topics: Abortion, Spontaneous; Animals; C-Reactive Protein; Chorionic Villi; Dinoprostone; Extracellular Mat | 2019 |
Preparation and characterization of indomethacin loaded films by piezoelectric inkjet printing: a personalized medication approach.
Topics: Animals; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Liberation; Excipients; Female; Indo | 2020 |
Mesenchymal stem cells promote healing of nonsteroidal anti-inflammatory drug-related peptic ulcer through paracrine actions in pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cell Transdifferentiation; Cul | 2019 |
Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways.
Topics: Acute Disease; Animals; Biomarkers; Carrageenan; Edema; Flavonoids; Heme Oxygenase-1; Indomethacin; | 2019 |
Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Antirheumatic Agents; Arthrit | 2020 |
Investigation of in vivo anti-inflammatory and anti-angiogenic attributes of coumarin-rich ethanolic extract of Melilotus indicus.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Coumarins; Disease Models, Animal; Dose- | 2021 |
Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats.
Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artesunate; Drug Therapy, Combination; Gastric Muco | 2020 |
Glycomacropeptide Ameliorates Indomethacin-Induced Enteropathy in Rats by Modifying Intestinal Inflammation and Oxidative Stress.
Topics: Animals; Caseins; Chemokine CXCL1; Disease Models, Animal; Gene Expression Regulation; Humans; Indom | 2020 |
Anti-inflammatory and anti-hyperalgesic effects of milnacipran in inflamed rats: involvement of myeloperoxidase activity, cytokines and oxidative/nitrosative stress.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Disease Models, Animal; Edema | 2020 |
Chlorogenic Acid Protects Against Indomethacin-Induced Inflammation and Mucosa Damage by Decreasing
Topics: Animals; Bacteroides; Bacteroides Infections; Chlorogenic Acid; Colitis; Fecal Microbiota Transplant | 2020 |
An Enzyme-Responsive Prodrug with Inflammation-Triggered Therapeutic Drug Release Characteristics.
Topics: Animals; Cell Death; Drug Liberation; Indomethacin; Inflammation; Interleukin-6; Lipopolysaccharides | 2020 |
Manjarix attenuated pain and joint swelling in a rat model of monosodium iodoacetate-induced osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis, Experimental; Cartilage, Articular; Collag | 2020 |
In vitro and in vivo anti-inflammatory effects of an ethanol extract from the aerial parts of Eryngium carlinae F. Delaroche (Apiaceae).
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Response Re | 2021 |
Histamine H
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dysbiosis; Feces; Histamine H2 | 2020 |
Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogenesis; Cell Count; Cell Line, Tumor; Collagen; Colonic Ne | 2021 |
Indomethacin loaded dextran stearate polymeric micelles improve adjuvant-induced arthritis in rats: design and in vivo evaluation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dextrans; Drug Delivery S | 2021 |
Probiotic lactobacilli as a promising strategy to ameliorate disorders associated with intestinal inflammation induced by a non-steroidal anti-inflammatory drug.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Supplements; Disease | 2021 |
Effect of Ester Derivative of Indomethacin on Immune Inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Indomethacin; Inflammatio | 2021 |
Intestinal inflammations increase efflux of innate lymphoid cells from the intestinal mucosa to the mesenteric lymph nodes through lymph-collecting ducts.
Topics: Animals; Immunity, Innate; Indomethacin; Inflammation; Intestinal Mucosa; Lymph Nodes; Lymphocytes; | 2021 |
Zuojin Pill ameliorates inflammation in indomethacin-induced gastric injury via inhibition of MAPK pathway.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Cytokines; Disease Models, Animal; Drugs, Chinese He | 2021 |
A comprehensive time course and correlation analysis of indomethacin-induced inflammation, bile acid alterations and dysbiosis in the rat small intestine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Dysbiosis; Indomethacin; Inf | 2021 |
Design, synthesis, and molecular docking of novel 3,5-disubstituted-1,3,4-oxadiazole derivatives as iNOS inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Enzyme Inhibitors; In | 2021 |
Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats.
Topics: Animals; Anti-Ulcer Agents; Apoptosis; Caspase 3; Esomeprazole; Female; Heme Oxygenase-1; Humans; In | 2021 |
A novel coating with universal adhesion and inflammation-responsive drug release functions to manipulate the osteoimmunomodulation of implants.
Topics: Animals; Cell Line; Coated Materials, Biocompatible; Drug Implants; Drug Liberation; Indomethacin; I | 2021 |
Physiologically relevant aspirin concentrations trigger immunostimulatory cytokine production by human leukocytes.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecox | 2021 |
A Novel Indomethacin-Tripeptide Hydrogel for Inhibiting Ocular Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Hydrogels; Indomethacin; Inflammation; Rabbits; Uveitis | 2021 |
Potential anti-inflammatory effect of LQFM-021 in carrageenan-induced inflammation: The role of nitric oxide.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 In | 2017 |
Indomethacin Enhances Fat Graft Retention by Up-Regulating Adipogenic Genes and Reducing Inflammation.
Topics: Adipogenesis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Graft Survival; Hum | 2017 |
Oxazolo[4,5-b]pyridine-Based Piperazinamides as GSK-3β Inhibitors with Potential for Attenuating Inflammation and Suppression of Pro-Inflammatory Mediators.
Topics: Amides; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Female; Glyco | 2017 |
Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Indomethacin; Inflammation; NF-E2-Relat | 2017 |
Synergistic Interaction of Matricaria Chamomilla Extract with Diclofenac and Indomethacin on Carrageenan-Induced Paw Inflammation in Rats.
Topics: Animals; Carrageenan; Diclofenac; Dose-Response Relationship, Drug; Drug Synergism; Indomethacin; In | 2017 |
Anti-inflammatory polymersomes of redox-responsive polyprodrug amphiphiles with inflammation-triggered indomethacin release characteristics.
Topics: Animals; Anti-Inflammatory Agents; Drug Liberation; HeLa Cells; Humans; Hydrodynamics; Indomethacin; | 2018 |
Complexes of Indomethacin with 4-Carbomethoxy-pyrrolidone PAMAM Dendrimers Show Improved Anti-inflammatory Properties and Temperature-Dependent Binding and Release Profile.
Topics: Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Cytokines; Dendrimers; Drug Carriers; Drug Compoundin | 2018 |
Gastroprotective and anti-ulcer effects of oxymatrine against several gastric ulcer models in rats: Possible roles of antioxidant, antiinflammatory, and prosurvival mechanisms.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Apoptosis; Catalase; | 2018 |
LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrage | 2018 |
Carrier free indomethacin microparticles for dry powder inhalation.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Chemist | 2018 |
Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes).
Topics: Animals; beta-Glucans; Cells, Cultured; Cytokines; Fungal Polysaccharides; Gastrointestinal Diseases | 2018 |
Mollaret Meningitis with a High Level of Cytokines in the Cerebrospinal Fluid Successfully Treated by Indomethacin.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cerebrospinal Fluid; Cytokines; Humans; Indomethacin | 2019 |
Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 I | 2019 |
A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-κB, COX-2 and iNOS signaling.
Topics: Acridones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalytic Domain; Cyclooxygenase 2; Cyc | 2019 |
Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Female; Glucuronidase; Hydrolases | 2012 |
Indomethacin in combination with exercise leads to muscle and brain inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Brain; Chemokine CCL2; Cytokines; Gen | 2013 |
Trikatu, a herbal compound that suppresses monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis.
Topics: Acute Disease; Alkenes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Female; | 2014 |
Nonsteroidal anti-inflammatory drugs (NSAID) sparing effects of glucosamine hydrochloride through N-glycosylation inhibition; strategy to rescue stomach from NSAID damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenase 2; Glucosamine; Glycosyl | 2013 |
Design of an anti-inflammatory composite nanosystem and evaluation of its potential for ocular drug delivery.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Chitosan; Drug Carriers; Drug Delivery Systems; Eye | 2013 |
Nonsteroidal anti-inflammatory drug induces proinflammatory damage in gastric mucosa through NF-κB activation and neutrophil infiltration: anti-inflammatory role of heme oxygenase-1 against nonsteroidal anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Chromatin Immunoprecipitation; | 2013 |
Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antipyretics; Carrageenan; Dinopro | 2012 |
In vitro, in vivo, and in silico evaluation of the bioresponsive behavior of an intelligent intraocular implant.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ciprofloxacin; Computer Simulation; Drug D | 2014 |
Novel N-phenylcarbamothioylbenzamides with anti-inflammatory activity and prostaglandin E2 inhibitory properties.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Carrageenan; Dinoprostone; Disease Models, Animal; Ed | 2013 |
Potentiation of indomethacin-induced anti-inflammatory response by montelukast in formalin-induced inflammation in rats.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclopropanes; Dose-Response Relationshi | 2013 |
Ultraviolet radiation-induced inflammation activates β-catenin signaling in mouse skin and skin tumors.
Topics: Animals; beta Catenin; Casein Kinase I; Cyclin D1; Cyclin D2; Cyclooxygenase 2; Cyclooxygenase 2 Inh | 2014 |
Anti-nociceptive and anti-inflammatory activities of Wrightia arborea.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apocynaceae; Disease Models, Animal; Edema; Female; I | 2013 |
Changes of Absorptive and Secretory Transporting System of (1 → 3) β-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2015 |
Study on analgesic and anti-inflammatory properties of Cordia myxa fruit hydro-alcoholic extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cordia; Disease Models | 2013 |
Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; Benzophenones; Bromobenzenes; C | 2014 |
Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Biomarkers; Cell Count; Cycloox | 2014 |
Acute oral toxicity and anti-inflammatory activity of hydroalcoholic extract from Lampaya medicinalis Phil in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransf | 2014 |
Deciphering PDT-induced inflammatory responses using real-time FDG-PET in a mouse tumour model.
Topics: Animals; Biological Transport; Cell Line, Tumor; Disease Models, Animal; Female; Fluorodeoxyglucose | 2014 |
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4.
Topics: Adherens Junctions; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Caco-2 Cells; CD3 | 2014 |
Anti-inflammatory effect of glycosaminoglycan derived from Gryllus bimaculatus (a type of cricket, insect) on adjuvant-treated chronic arthritis rat model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; C-Reactive Protein; Cell Line, Tumor; Di | 2014 |
Effect of inflammatory factor-induced cyclo-oxygenase expression on the development of reperfusion-related no-reflow phenomenon in acute myocardial infarction.
Topics: Acute Disease; Animals; C-Reactive Protein; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhib | 2015 |
Assessment of pharmacological activities of two medicinal plant of Bangladesh: Launaea sarmentosa and Aegialitis rotundifolia roxb in the management of pain, pyrexia and inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Aspirin; Asteraceae; Ban | 2014 |
Controlled release of indomethacin from alginate-poloxamer-silicon carbide composites decrease in-vitro inflammation.
Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Compounds, Inorganic; Cell Line; | 2015 |
Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-α-induced insulin resistance.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Aspirin; Cinnamates; Forkhead Box Protein O1; F | 2015 |
Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeic Acids; Eye Diseases; Indomethacin | 2015 |
Acacia ferruginea inhibits inflammation by regulating inflammatory iNOS and COX-2.
Topics: Acacia; Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Chronic Disease; Cyclooxygena | 2016 |
Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Copper; Disease Models, A | 2015 |
Boswellia carterii liquisolid systems with promoted anti-inflammatory activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Boswellia; Carrageenan; Cellulose; Chemistr | 2015 |
Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Camellia sinensis; Catechin; Cell Migration Assays; I | 2015 |
Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Cyc | 2015 |
Study on Self-Assembled Well-Defined PEG Graft Copolymers as Efficient Drug-Loaded Nanoparticles for Anti-Inflammatory Therapy.
Topics: Delayed-Action Preparations; Drug Carriers; Humans; Hydrogen-Ion Concentration; Indomethacin; Inflam | 2015 |
Design of an Inflammation-Sensitive Polyelectrolyte-Based Topical Drug Delivery System for Arthritis.
Topics: Administration, Topical; Alginates; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cellulose; C | 2016 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
Rheumatoid Arthritis Presenting as Acute Myopericarditis.
Topics: Angina Pectoris; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Sedimentation | 2016 |
A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimen | 2016 |
Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclooxygenase 2; Disease Models, Animal; D | 2016 |
Comparative analysis of local effects caused by Bothrops alternatus and Bothrops moojeni snake venoms: enzymatic contributions and inflammatory modulations.
Topics: Animals; Anti-Inflammatory Agents; Bothrops; Brazil; Crotalid Venoms; Histamine; Histamine Antagonis | 2016 |
Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Chromans; Gene Expression Regulation; Humans; Indome | 2016 |
Effects of Mesalazine on Morphological and Functional Changes in the Indomethacin-Induced Inflammatory Bowel Disease (Rat Model of Crohn's Disease).
Topics: Animals; Crohn Disease; Disease Models, Animal; Glucuronates; Indomethacin; Inflammation; Inflammato | 2017 |
[Inhibition of prostaglandins synthesis in the inflamed site results in opioid-mediated hypoalgesia in rats].
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Carrageenan; Indomethacin; Inflammation; Naloxone; Pain | 2016 |
Potentiation of indomethacin-induced anti-inflammatory response by pioglitazone in carrageenan-induced acute inflammation in rats: Role of PPARγ receptors.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dinoprostone; Drug Synerg | 2016 |
Proinflammatory responses driven by non-gluten factors are masked when they appear associated to gliadins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Enzyme-Linked Immunosorbent Assa | 2016 |
Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation.
Topics: Allergens; Animals; Antihypertensive Agents; Asthma; CD4-Positive T-Lymphocytes; Cell Proliferation; | 2016 |
Direct analysis of prostaglandin-E2 and -D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry.
Topics: Animals; Biological Assay; Biological Products; Chalcones; Chromatography, High Pressure Liquid; Cyt | 2016 |
Development of microparticles for oral administration of the non-conventional radical scavenger IAC and testing in an inflammatory rat model.
Topics: Acetaminophen; Administration, Oral; Animals; Disease Models, Animal; Free Radical Scavengers; Glyce | 2016 |
Yeast Microcapsule-Mediated Targeted Delivery of Diverse Nanoparticles for Imaging and Therapy via the Oral Route.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Capsules; Carcinoma | 2017 |
The influence of seasonality on the content of goyazensolide and on anti-inflammatory and anti-hyperuricemic effects of the ethanolic extract of Lychnophora passerina (Brazilian arnica).
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Brazil; Bridged-Ring Compounds; Chromatography, High | 2017 |
Evaluation of region selective bilirubin-induced brain damage as a basis for a pharmacological treatment.
Topics: Animals; Bilirubin; Brain; Brain Diseases, Metabolic; Cell Survival; Curcumin; Encephalitis; Hyperbi | 2017 |
Pro-inflammatory immune-to-brain signaling is involved in neuroendocrine responses to acute emotional stress.
Topics: Animals; Brain; Cyclooxygenase Inhibitors; Emotions; Hypothalamo-Hypophyseal System; Indomethacin; I | 2017 |
Physalis angulata extract exerts anti-inflammatory effects in rats by inhibiting different pathways.
Topics: Adenosine Deaminase; Animals; Anti-Inflammatory Agents; Brazil; Dinoprostone; Dose-Response Relation | 2008 |
Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst.
Topics: Animals; Anti-Inflammatory Agents; Bacopa; Cyclooxygenase 2; Disease Models, Animal; Dose-Response R | 2008 |
Enzyme-modified cheese exerts inhibitory effects on allergen permeation in rats suffering from indomethacin-induced intestinal inflammation.
Topics: Allergens; Amino Acid Sequence; Animals; Caco-2 Cells; Caseins; Cell Membrane Permeability; Cheese; | 2008 |
How reliable an indicator of inflammation is myeloperoxidase activity?
Topics: Animals; Indomethacin; Inflammation; Interleukin-6; Male; Mice; Peroxidase; Turpentine | 2008 |
Beneficial effects of vegetable oils (corn, olive and sunflower oils) and alpha-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats.
Topics: alpha-Tocopherol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Corn Oil; Indometh | 2008 |
Decreased expression of kisspeptin mediates acute immune/inflammatory stress-induced suppression of gonadotropin secretion in female rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Gonadotropin-Releasing Hormone; Hypothalam | 2008 |
Anti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animals.
Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relatio | 2008 |
The antiinflammatory, gastroprotective and antioxidant activities of Hieracium gymnocephalum extract.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Asteraceae; Dose-Response Relati | 2008 |
Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses.
Topics: Animals; Cyclooxygenase Inhibitors; Dendritic Cells; Immunologic Memory; Indomethacin; Inflammation; | 2008 |
Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dipyrone; Fre | 2008 |
Anti-inflammatory and anti-pyretic activities of earthworm extract-Lampito mauritii (Kinberg).
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Disease Models, Animal; | 2009 |
Anti-inflammatory, analgesic and wound healing activities of the leaves of Memecylon edule Roxb.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Dose-Response Relationship, | 2009 |
Afferent nerve sensitivity is decreased by an iNOS-dependent mechanism during indomethacin-induced inflammation in the murine jejunum in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Electrophysiology; Humans; Indomethaci | 2009 |
Mechanisms involved in the rat peritoneal leukocyte migration induced by a Kunitz-type inhibitor isolated from Dimorphandra mollis seeds.
Topics: Analysis of Variance; Animals; Benzoquinones; Celecoxib; Cell Movement; Dexamethasone; Fabaceae; Ind | 2009 |
Inhibition of monosodium urate crystal-induced inflammation by withaferin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Disease Models, Animal; Ergosterol; | 2008 |
Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-R | 2009 |
Preclinical pharmacokinetic and pharmacodynamic evaluation of thiazolidinone PG15: an anti-inflammatory candidate.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cycloox | 2009 |
Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-St | 2010 |
Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats.
Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents | 2009 |
Effects of indomethacin-loaded nanocapsules in experimental models of inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Drug Evaluation, Preclinical; Indomethac | 2009 |
Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Blotting, Western; Brain; Cy | 2009 |
Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Enzyme Induction; Gastri | 2009 |
Tenosynovitis as a possible feature of immune reconstitution syndrome during highly active antiretroviral treatment (HAART).
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Antire | 2009 |
Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis.
Topics: Animals; Animals, Newborn; Cyclooxygenase 2 Inhibitors; Dinoprostone; Epoprostenol; Gene Expression | 2009 |
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; | 2009 |
Relative inhibitory activity of bile acids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, and chenodeoxycholic acid inhibition of tumour promotion in mouse skin two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Bile A | 2009 |
Modulation of inflammatory response by selective inhibition of cyclooxygenase-1 and cyclooxygenase-2 in acute kidney injury.
Topics: Acute Kidney Injury; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokin | 2010 |
Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Cyclooxygenase Inhi | 2010 |
Leukotriene B4 creates a favorable microenvironment for murine melanoma growth.
Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Carrageenan; Cell Growth Processes; Cell Line, Tumo | 2009 |
Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats.
Topics: Acute Disease; Animals; Carrageenan; Cystitis; Edema; Hindlimb; Ifosfamide; Indomethacin; Inflammati | 2009 |
Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophy.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Apoptosis; Bio | 2009 |
6-Shogaol inhibits monosodium urate crystal-induced inflammation--an in vivo and in vitro study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Catechols; Crystallization; Dose-Res | 2010 |
Evaluation of anti-inflammatory and antioxidant activities of Peltigera rufescens lichen species in acute and chronic inflammation models.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Chronic Disease; Diclof | 2010 |
Trioxsalen derivatives with lipoxygenase inhibitory activity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Carrageenan; Edema; Female; Fre | 2009 |
Methamphetamine-induced neuroinflammation and neuronal dysfunction in the mice hippocampus: preventive effect of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD11b Antigen; Central Nervous System Stimulants; | 2010 |
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Disease Models, Animal; Female; Indomethacin | 2010 |
Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arachidonate 5-Lipoxygenase; Arthrit | 2010 |
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr | 2010 |
Analgesic and anti-inflammatory effects of aqueous extract of Zea mays husk in male Wistar rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Dose-Response Relationship, Drug; F | 2010 |
Differences between orofacial inflammation and cancer pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Carcinoma 256, Wa | 2010 |
Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Colitis; Cyclooxygen | 2010 |
Acemetacin antinociceptive mechanism is not related to NO or K+ channel pathways.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Indo | 2010 |
Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2010 |
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Rele | 2010 |
Role of adrenal gland hormones in the anti-inflammatory effect mechanism of tamoxifen, a partial antagonist for oestrogen receptors, and relation with COX levels.
Topics: Adrenal Glands; Adrenalectomy; Animals; Anti-Inflammatory Agents; Corticosterone; Cyclooxygenase 1; | 2011 |
Intrauterine inflammation as a risk factor for persistent ductus arteriosus patency after cyclooxygenase inhibition in extremely low birth weight infants.
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Fetal Diseases; Humans; Indomethacin; | 2010 |
Anti-inflammatory and analgesic effects displayed by peptides derived from PKI55 protein, an endogenous protein kinase C inhibitor.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Dose-Response | 2010 |
Anti-inflammatory activity of Trichosanthes cucumerina Linn. in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Response Relationship, | 2010 |
Celecoxib induces tolerance in a model of peripheral inflammatory pain in rats.
Topics: Analgesics; Analysis of Variance; Animals; Celecoxib; Dinoprostone; Hyperalgesia; Indomethacin; Infl | 2010 |
Protective effects of indomethacin-loaded nanocapsules against oxygen-glucose deprivation in organotypic hippocampal slice cultures: involvement of neuroinflammation.
Topics: Animals; Blotting, Western; Cytokines; Enzyme Activation; Enzyme Induction; Glucose; Hippocampus; In | 2010 |
Phenotypes and peripheral mechanisms underlying inflammatory pain-related behaviors induced by BmK I, a modulator of sodium channels.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, | 2010 |
Protective effects of indomethacin and cyclophosphamide but not of infliximab on liver metabolic changes caused by adjuvant-induced arthritis.
Topics: Animals; Antibodies, Monoclonal; Arthritis, Experimental; Cyclophosphamide; Indomethacin; Inflammati | 2011 |
Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.
Topics: Adamantane; Administration, Oral; Animals; Ankle; Ankle Joint; Arthritis, Experimental; Body Weight; | 2011 |
In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Brazil; Disease Models, Animal; Edema; Electropho | 2011 |
Anti-inflammatory activity of Penstemon gentianoides and Penstemon campanulatus.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Edema; Flavonoids; Indometh | 2011 |
A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzenesulfonamides; Carrageenan; Celecoxib; Chronic | 2011 |
Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Commiphora; Dinoprosto | 2011 |
Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Catalase; Edema; Flavanones; Free Radi | 2011 |
Visfatin induces sickness responses in the brain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Body Weight; Brain; Cytokines; E | 2011 |
Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cartilage, Articular; Dexamethas | 2011 |
Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Chlorogenic | 2011 |
Anti-inflammatory activities, triterpenoids, and diarylheptanoids of Alnus acuminata ssp. arguta.
Topics: Alnus; Animals; Anti-Inflammatory Agents; Antioxidants; Diarylheptanoids; Drug Evaluation, Preclinic | 2011 |
The effect of montelukast in a model of gouty arthritis induced by sodium monourate crystals.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Cell Migration Assays, | 2011 |
Impact of early malnourishment on the chronic inflammatory response and its implications for the effect of indomethacin on Wistar rats.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bioethics; C-Reactive Protein; Female | 2011 |
Intra-articular administration of tachykinin NK₁ receptor antagonists reduces hyperalgesia and cartilage destruction in the inflammatory joint in rats with adjuvant-induced arthritis.
Topics: Analgesics; Androstanes; Animals; Ankle Joint; Arthritis, Experimental; Benzimidazoles; Cartilage; F | 2011 |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes.
Topics: Acetic Acid; Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Coordination Complexes; Cryst | 2011 |
Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages.
Topics: Aldehyde Reductase; Animals; Arachidonic Acid; Cells, Cultured; Endotoxins; Indomethacin; Inflammati | 2011 |
Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer.
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Halogenation; Humans; Indomethacin; Inflamm | 2011 |
Models of inflammation: measuring gastrointestinal ulceration in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Female; Indomethacin; Infl | 2001 |
ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation.
Topics: Administration, Oral; Aminocaproates; Aminocaproic Acid; Animals; Anti-Ulcer Agents; Arteries; Blood | 2012 |
The anti-inflammatory activity of dillapiole and some semisynthetic analogues.
Topics: Allyl Compounds; Animals; Anti-Inflammatory Agents; Carrageenan; Chromatography; Dioxoles; Disease M | 2011 |
Influence of influenza A infection on capsaicin-induced responses in murine airways.
Topics: Animals; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Capsaicin; Carbachol; Cyclooxygenase Inhi | 2012 |
Reduction of post-surgical pericardial adhesions using a pig model.
Topics: Animals; Biological Availability; Biomarkers; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Mod | 2012 |
Alpinia calcarata Roscoe: a potent antiinflammatory agent.
Topics: Alpinia; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Histamine; Indomethacin; Inflammatio | 2012 |
Early undernutrition is associated with attenuated inflammatory response and alteration in pharmacological efficacy of indomethacin in rats.
Topics: Analysis of Variance; Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Birth Weight; C | 2012 |
Anti-inflammatory effect of piperine in adjuvant-induced arthritic rats--a biochemical approach.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzodioxoles; | 2012 |
Acute crystalline arthritis in an artificial knee.
Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replace | 2012 |
Toward homeostasis: regulatory dendritic cells from the bone marrow of mice with inflammation of the airways and peritoneal cavity.
Topics: Alum Compounds; Animals; B7-2 Antigen; Bone Marrow Cells; CD11c Antigen; Cell Differentiation; Cell | 2012 |
Involvement of tachykinins and NK1 receptor in the joint inflammation with collagen type II-specific monoclonal antibody-induced arthritis in mice.
Topics: Androstanes; Animals; Antibodies, Monoclonal; Arthritis, Experimental; Benzimidazoles; Collagen Type | 2012 |
Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein.
Topics: Activating Transcription Factor 6; Animals; Anthraquinones; Anti-Inflammatory Agents; Aquaporin 4; A | 2012 |
Anti-inflammatory and analgesic properties of the ethanolic extract of Cnidoscolus aconitifolius in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2011 |
Immunomodulatory effect of candesartan on indomethacin-induced gastric ulcer in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Antioxidants; Benzimidazo | 2012 |
Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Arachidonic Acid; Cymenes; Edema; Female; Indo | 2012 |
Assembled nanomedicines as efficient and safe therapeutics for articular inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; beta-Cyclodextrins; Carra | 2012 |
Anti-inflammatory potential of curcumin and quercetin in rats: role of oxidative stress, heme oxygenase-1 and TNF-α.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Drug Interacti | 2014 |
Polyphenolic profile and biological activity of Salvia splendens leaves.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Diabetes Mellitus, Experimental; Dis | 2012 |
Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Capil | 2013 |
The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Central Nervous S | 2013 |
Analgesic and anti-inflammatory activity of podophyllotoxin derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carbazoles; Cell Line, Tumor; | 2013 |
Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Activati | 2013 |
Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; D | 2002 |
Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Dose-Respons | 2002 |
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2002 |
Anti-inflammatory sesquiterpene lactones from Lourteigia ballotaefolia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Croton Oil; Disease Models, Animal; In | 2002 |
Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation.
Topics: Animals; Carrageenan; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhib | 2002 |
Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats.
Topics: Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dino | 2002 |
Butorphanol decreases edema following carrageenan-induced paw inflammation in rats.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butorphanol; Carrageenan; Dose | 2002 |
A spinal mechanism for the peripheral anti-inflammatory action of indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Disease Models, Animal; | 2003 |
Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; | 2002 |
Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non- | 2003 |
Effects of endothelin-1 on epithelial ion transport in human airways.
Topics: Amiloride; Binding Sites; Biological Transport; Bronchi; Bumetanide; Cells, Cultured; Chlorine; Cycl | 2003 |
The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Celecoxib; Dexamethasone; Dose-Response Relationship | 2003 |
Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Carr | 2003 |
Participation of corticosteroids and effects of indomethacin on the acute inflammatory response of rats fed n-6 or n-3 polyunsaturated fatty acid-rich diets.
Topics: Acute Disease; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageena | 2003 |
Effect of N-acetylcysteine on microcirculation of mucosa in rat ileum in a model of intestinal inflammation.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Free Radical Scavengers; Indomethacin; Inflammation | 2003 |
Effects of endotoxin and macrophage-related cytokines on the contractile activity of the gravid murine uterus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Endotoxins; Female; In Vitro Techniques | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Heme oxygenase-1 induction may explain the antioxidant profile of aspirin.
Topics: Antioxidants; Aspirin; Bilirubin; Carbon Monoxide; Cell Line; Cell Survival; Cells, Cultured; Cycloo | 2003 |
Studies on novel 7-acyl-5-chloro-2-oxo-3H-benzoxazole derivatives as potential analgesic and anti-inflammatory agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoxazoles; Capillary Perme | 2003 |
Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice.
Topics: Acute Disease; Animals; Arachidonic Acid; Carrageenan; Celecoxib; Croton Oil; Cyclooxygenase 1; Cycl | 2003 |
ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.
Topics: Acetates; Adrenalectomy; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents | 1963 |
THE METABOLITES OF INDOMETHACIN, A NEW ANTI-INFLAMMATORY DRUG.
Topics: Animals; Anti-Inflammatory Agents; Biomedical Research; Body Fluids; Carbon Isotopes; Dogs; Guinea P | 1964 |
ANTI-INFLAMMATORY AND ANTIPYRETIC PROPERTIES OF N-(2,6-DICHLORO-M-TOLYL)ANTHRANILIC ACID (CI-583).
Topics: Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antipyretics; Aspirin; | 1965 |
Characterization of "unhealed gastric ulcers" produced with chronic exposure of acetic acid ulcers to indomethacin in rats.
Topics: Acetic Acid; Animals; Dinoprostone; Disease Models, Animal; Drug Administration Schedule; Fibrosis; | 2003 |
Inflammatory blockade restores adult hippocampal neurogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Apoptosis; Cell Differentiation; Cel | 2003 |
Induction of distinct sets of secretory phospholipase A(2) in rodents during inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Chromans; Edema; Enzyme Induction; | 2003 |
Studies on the anti-inflammatory effect of fluoxetine in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyc | 2004 |
Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Blood Sedim | 2004 |
Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion Molecules; Chemokin | 2004 |
Inflammatory response of human tendon fibroblasts to cyclic mechanical stretching.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Bicycling; Cell Culture | 2004 |
Tetrazolo[1,5-a]quinoline as a potential promising new scaffold for the synthesis of novel anti-inflammatory and antibacterial agents.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; G | 2004 |
Use of rubidium, manganese, and zinc as tracers to measure intestinal permeability by PIXE analysis: basal study in an experimental enteritis model.
Topics: Animals; Crohn Disease; Enteritis; Indomethacin; Inflammation; Intestinal Absorption; Intestine, Sma | 2004 |
Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Cross-Linking Reagents; Cycloox | 2004 |
Effects of aminoguanidine and cyclooxygenase inhibitors on nitric oxide and prostaglandin production, and nitric oxide synthase and cyclooxygenase expression induced by lipopolysaccharide in the estrogenized rat uterus.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinopr | 2004 |
Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Hepat | 2004 |
The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Citru | 2004 |
Tart cherry anthocyanins suppress inflammation-induced pain behavior in rat.
Topics: Administration, Oral; Analysis of Variance; Animals; Anthocyanins; Anti-Inflammatory Agents, Non-Ste | 2004 |
E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.
Topics: Animals; Arachidonate 5-Lipoxygenase; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase | 2004 |
Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Electroacupuncture; Freund's Adjuvant; Hot | 2004 |
Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice.
Topics: Amidines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Arthritis, Experimental; Ben | 2004 |
Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture.
Topics: Cells, Cultured; Chlorpheniramine; Coloring Agents; Connexin 43; Cyclic AMP; Cyclooxygenase Inhibito | 2004 |
Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Carrageenan; | 2004 |
Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclooxygenase Inhibitors; Cytokine | 2005 |
Solubility enhancement of indomethacin with poly(amidoamine) dendrimers and targeting to inflammatory regions of arthritic rats.
Topics: Animals; Arthritis, Experimental; Drug Delivery Systems; Indomethacin; Inflammation; Male; Nylons; R | 2004 |
[Inflammation, nonsteroidal anti-inflammatory drugs and Alzheimer disease].
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cyclooxy | 2004 |
Induction of galanin-like peptide gene expression in the arcuate nucleus of the rat after acute but not chronic inflammatory stress.
Topics: Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Body Temperature; Cyclooxygenase Inh | 2005 |
Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Carbon Tetrachloride; Carbon Tetrachlo | 2005 |
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Ani | 2005 |
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Female; Humans; Indom | 2005 |
Behavioral responses during the forced swim test are not affected by anti-inflammatory agents or acute illness induced by lipopolysaccharide.
Topics: alpha-MSH; Analysis of Variance; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic | 2005 |
Correlations between edema and the immediate and prolonged painful consequences of inflammation: therapeutic implications?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bee Venoms; Edema; Indomethacin; Inflammation; Mal | 2005 |
Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Case-Control Studies; Crohn | 2005 |
Lethal, oedema, haemorrhagic activity of spotted butterfish (Scatophagus argus, Linn) sting extract and its neutralization by antiserum and pharmacological antagonists.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Cyproheptadine; Edema; Edetic | 2005 |
Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Brain; Camphanes; Can | 2005 |
Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Down-Regulation; Ileitis; | 2005 |
The effects of non-selective, preferential-selective and selective COX-inhibitors on the growth of experimental and human tumors in mice related to prostanoid receptors.
Topics: Amyloid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Line, Tumor; Cell Surviva | 2005 |
Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Area Under Curve; Camphanes; Can | 2005 |
Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents.
Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; | 2005 |
CC 05, a novel anti-inflammatory compound, exerts its effect by inhibition of cyclooxygenase-2 activity.
Topics: Animals; Anti-Inflammatory Agents; Baculoviridae; Benzenesulfonamides; Carrageenan; Celecoxib; Cyclo | 2005 |
The peroxisome proliferator-activated receptor alpha activator, Wy14,643, is anti-inflammatory in vivo.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Dinoprostone; | 2005 |
Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli.
Topics: Animals; Blood-Brain Barrier; Brain; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase I | 2005 |
Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cell Count; Cell Division; Cell Lineag | 2005 |
Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Bacterial Pro | 2005 |
Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 Cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases | 2005 |
Changes in the human peritoneal mesothelial cells during aging.
Topics: Adult; Aged; Aging; Cytokines; Epithelial Cells; Female; Humans; Indomethacin; Inflammation; Male; M | 2006 |
Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclobutanes; Diclofenac; Female; Formaldehyde; In | 2006 |
Topical application of a novel, hydrophilic gamma-tocopherol derivative reduces photo-inflammation in mice skin.
Topics: Administration, Topical; alpha-Tocopherol; Animals; Antioxidants; Cyclooxygenase 2; Cyclooxygenase I | 2006 |
Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs.
Topics: Animals; Capsaicin; Citric Acid; Cough; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibit | 2006 |
Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anticoagulants; Calcium; Cyclooxygenase 2 Inhibitors; Daltepa | 2006 |
Experimental peritonitis induced by oral administration of indomethacin in Mongolian gerbils.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Female; Gerbillinae; Indomethacin; | 2006 |
Discovery of potent CRTh2 (DP2) receptor antagonists.
Topics: Asthma; Chemistry, Pharmaceutical; Drug Design; Humans; Indomethacin; Inflammation; Inhibitory Conce | 2006 |
Cyclooxygenase 2 induced by Kaposi's sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression.
Topics: Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial | 2006 |
The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats.
Topics: Animals; Area Under Curve; Arthritis, Experimental; Biocompatible Materials; Chemistry, Pharmaceutic | 2007 |
Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors.
Topics: Animals; Dinoprostone; Female; Indomethacin; Inflammation; Keratinocytes; Mice; Naphthalenes; Phenyl | 2007 |
Anti-inflammatory activity of crude extract and fractions of Nectandra falcifolia leaves.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Croton Oil; Dru | 2006 |
Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Arthritis, Gouty; Cell Line; Humans; Indomethacin; In | 2006 |
Inhibition of lipopolysaccharide-induced prostaglandin E2 production and inflammation by the Na+/H+ exchanger inhibitors.
Topics: Amiloride; Animals; Arachidonic Acid; Blotting, Western; Capillary Permeability; Cell Line; Cell Sur | 2007 |
Folate coupled poly(ethyleneglycol) conjugates of anionic poly(amidoamine) dendrimer for inflammatory tissue specific drug delivery.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biocompatible Materials; | 2007 |
Apoptotic mimicry: phosphatidylserine liposomes reduce inflammation through activation of peroxisome proliferator-activated receptors (PPARs) in vivo.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Carrageenan; Dose-Response Relationship, Drug; Drug Ad | 2007 |
Potential role for epidermal Langerhans cells in nicotinic acid-induced vasodilatation in the mouse.
Topics: Animals; Epidermis; Hydrocortisone; Indomethacin; Inflammation; Langerhans Cells; Laser-Doppler Flow | 2007 |
TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor.
Topics: Animals; Antibodies; Bradykinin; Bradykinin B1 Receptor Antagonists; Bradykinin B2 Receptor Antagoni | 2007 |
Indomethacin enhances the cytotoxicity of recombinant human lymphotoxin alpha on tumor cells by suppressing NFkappaB signaling.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Indome | 2007 |
Mechanisms underlying the anti-inflammatory activity and gastric safety of acemetacin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Biotransfo | 2007 |
Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Carrageenan; Dos | 2008 |
Anti-ulcer, anti-inflammatory and antioxidant activities of the n-butanol fraction from Pteleopsis suberosa stem bark.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Combretaceae; Dose-Response Rela | 2008 |
Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Disease Models, An | 2007 |
Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.
Topics: Acute Disease; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Contusions | 2008 |
Pharmacological intervention to the inflammatory response from decompression sickness in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Decompression Sickness; Hydroxyurea; Indoles; Indomethacin; Infl | 2008 |
Efficacy of tacrolimus in inhibiting inflammation caused by carrageenan in a murine model of air pouch.
Topics: Adenosine Deaminase; Animals; Carrageenan; Dexamethasone; Disease Models, Animal; Immunosuppressive | 2008 |
Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice.
Topics: Analgesics; Animals; Arthritis, Experimental; Benzeneacetamides; Cells, Cultured; Chemokine CXCL1; C | 2008 |
Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice.
Topics: Animals; Anti-Inflammatory Agents; Benzopyrans; Disease Models, Animal; Ear; Edema; Emericella; Fema | 2008 |
Simulated digest of a glucosamine-based equine nutraceutical modifies effect of IL-1 in a cartilage explant model of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Drug Therapy, Combination; G | 2008 |
[Contribution to the evaluation of anti-inflammatory agents in vitro].
Topics: Animals; Anti-Inflammatory Agents; Cortisone; Esterases; Flufenamic Acid; Indomethacin; Inflammation | 1966 |
Presence of a general irritation and inhibition of a local inflammation.
Topics: Acetates; Animals; Aspirin; Blood; Carrageenan; Coloring Agents; Edema; Female; Formaldehyde; Hypert | 1966 |
A new anti-inflammatory test, utilizing the chorio-allantoic membrane of the chick embryo.
Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Anti-Inflammatory Agents; Betamethaso | 1967 |
A demonstration of anti-inflammatory effect of indomethacin.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Indomethacin; Inflammation; Middle | 1967 |
Suppressive effects of indomethacin on crystal-induced inflammation in canine joints and on neutrophilic motility in vitro.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis; Blood Flow Velocity; Blood Pressure; Do | 1967 |
[Recent discoveries in the field of mediators of anti-inflammation: leukotrienes].
Topics: 5,8,11,14-Eicosatetraynoic Acid; Anti-Inflammatory Agents; Antigen-Antibody Complex; Arachidonic Aci | 1984 |
Leukotriene B4, polymorphonuclear leukocytes and inflammatory exudates in the rat.
Topics: Animals; Antibody Specificity; Calcimycin; Carrageenan; Chromatography, High Pressure Liquid; Exudat | 1984 |
Regulation of the human polymorphonuclear leukocyte inflammatory response by inhibitors of arachidonic acid metabolism.
Topics: Anticoagulants; Antioxidants; Arachidonic Acid; Arachidonic Acids; Catechols; Cytochrome c Group; Ei | 1984 |
Indomethacin inhibits the in vivo formation of the lipoxygenase product HETE (12-hydroxy-5,8,10,14-eicosatetraenoic acid) during granulomatous inflammation in the rat.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acids; Carrageenan; Granuloma; Indo | 1980 |
Effect of histamine H1- and H2-receptor antagonists, steroidal and non-steroidal anti-inflammatory agents on carrageenin-induced inflammation of the guinea-pig ear.
Topics: Animals; Anti-Inflammatory Agents; Body Temperature; Carrageenan; Cimetidine; Ear; Glucocorticoids; | 1982 |
The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Asp | 1983 |
[Scopolamine and its pharmacological effects on some experimental inflammation tests].
Topics: Animals; Carrageenan; Cellulose; Dextrans; Edema; Flufenamic Acid; Granuloma; Indomethacin; Inflamma | 1980 |
Cyclic nucleotides in immune responses and allergy.
Topics: Adenosine; Animals; Antigens; Basophils; Cyclic AMP; Histamine Release; Humans; Hypersensitivity, Im | 1980 |
Dextran and carrageenan evoke different inflammatory responses in rat with respect to composition of infiltrates and effect of indomethacin.
Topics: Animals; Carrageenan; Dextrans; Exudates and Transudates; Histamine Release; Indomethacin; Inflammat | 1982 |
[Effect of inhibitors of prostaglandin synthesis on the eye].
Topics: Animals; Burns, Chemical; Diclofenac; Eye; Eye Burns; Eye Diseases; Humans; Indomethacin; Inflammati | 1983 |
Haptoglobin and lipoperoxides in rabbit plasma under turpentine- and endotoxin-induced inflammation.
Topics: Animals; Drug Interactions; Endotoxins; Female; Haptoglobins; Indomethacin; Inflammation; Lipid Pero | 1984 |
Inflammatory properties of lipoxygenase products and the effects of indomethacin and BW755C on prostaglandin production, leukocyte migration, and plasma exudation in rabbit skin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ara | 1982 |
Comparison of the effects of glucocorticoid and indomethacin treatment on the acute inflammatory reaction in rabbits.
Topics: Aging; Animals; Arthus Reaction; Escherichia coli Infections; Exudates and Transudates; Glucocortico | 1983 |
Inhibition of mononuclear leukocyte accumulation by the arachidonic acid lipoxygenase inhibitor BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonate Lipoxygenases; C | 1983 |
The effects of locally injected antibiotic on carrageenan-induced granuloma in rats.
Topics: Animals; Body Weight; Carrageenan; Chloramphenicol; Collagen; Glycosaminoglycans; Granuloma; Indomet | 1984 |
[Prostaglandins, indomethacin and the physiopathology of various systems].
Topics: Cardiovascular System; Coronary Disease; Drug Interactions; Humans; Indomethacin; Inflammation; Kidn | 1984 |
[Comparative study of platelet anti-aggregation effect of several anti-inflammatory agents].
Topics: Adenosine Diphosphate; Collagen; Cyclic AMP; Epinephrine; Humans; In Vitro Techniques; Indomethacin; | 1983 |
The inflammatory reaction in an experimental model of open wounds in the rat. The effect of arachidonic acid metabolites.
Topics: Animals; Arachidonic Acids; Biotransformation; Dinoprostone; Granulation Tissue; Indomethacin; Infla | 1984 |
Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic | 1984 |
Effects of piroxicam on mononuclear cells. Comparison with other antiarthritic drugs.
Topics: Anti-Inflammatory Agents; Antimalarials; Arthritis, Rheumatoid; Dinoprostone; Gold; Humans; Immunosu | 1984 |
Inhibition of PG production by MDL 035, a new non-steroidal non-acidic anti-inflammatory compound, in rat gastric mucosa and inflammatory exudate.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dinoproston | 1984 |
Effect of phorbol myristate acetate, a tumor-promoting agent, on the growth of Mycobacterium lepraemurium in the mouse footpad.
Topics: Acetates; Acetic Acid; Animals; Dexamethasone; Female; Hypersensitivity, Delayed; Indomethacin; Infl | 1983 |
Fenflumizole: interactions with the arachidonic acid cascade.
Topics: Animals; Arachidonic Acids; Aspirin; Blood Platelets; Cattle; Cyclooxygenase Inhibitors; Dinoproston | 1983 |
A new sensitive fluorometric method for measurement of vascular permeability.
Topics: Animals; Capillary Permeability; Chromatography, Gel; Dexamethasone; Fluorescein-5-isothiocyanate; F | 1984 |
Involvement of prostaglandins in LPS-mediated regulation of plasminogen activator synthesis by inflammatory macrophages.
Topics: Animals; Bacterial Toxins; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Endotoxins; Enteroto | 1984 |
Therapeutic reduction of ongoing carrageenin-induced inflammation by lipoxygenase, but not cyclooxygenase inhibitors.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Aspirin; Carrageenan; Cycloox | 1984 |
On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Alprostadil; Anaphylaxis; Animals; Ant | 1984 |
Characteristics and effect of antiinflammatory drugs on adriamycin-induced inflammation in the mouse paw.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Capillary Permeability; Diphenhydramine; Doxorubicin; Fe | 1980 |
In vivo interaction of nonsteroidal anti-inflammatory drugs on the locomotion of neutrophils elicited by acute non-specific inflammations in the rat--effect of indomethacin, ibuprofen and flurbiprofen.
Topics: Animals; Anti-Inflammatory Agents; Blood; Calcium Pyrophosphate; Chemotaxis, Leukocyte; Flurbiprofen | 1984 |
Blockade by anti-glucocorticoids, actinomycin D and cycloheximide of the anti-inflammatory action of some Kampohozai (Chinese traditional medicines) against serotonin.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Cycloheximide; Dactinomycin; Dexamethasone; Drugs, Chine | 1984 |
In vivo effects of indomethacin and flurbiprofen on the locomotion of neutrophils elicited by immune and non-immune inflammation in the rat.
Topics: Animals; Cell Movement; Flurbiprofen; Hypersensitivity; In Vitro Techniques; Indomethacin; Inflammat | 1984 |
Determination of inflamed paw surface temperature in rats.
Topics: Animals; Body Temperature; Foot; Indomethacin; Inflammation; Male; Rats; Rats, Inbred Strains | 1984 |
Acute intraocular pressure elevation produced by argon laser trabeculoplasty in the cynomolgus monkey.
Topics: Animals; Disease Models, Animal; Female; Indomethacin; Inflammation; Laser Therapy; Lasers; Macaca f | 1984 |
[Effects of topical indomethacin on response and postsurgical inflammation in planned extracapsular cataract extraction and lens phacoemulsification].
Topics: Administration, Topical; Adult; Aged; Cataract Extraction; Humans; Indomethacin; Inflammation; Middl | 1983 |
Pharmacodynamics and toxicology of fenflumizole, a new non-steroidal anti-inflammatory imidazole derivative.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dogs; Edema; Female; Guinea Pigs; Hemodynamics; Hind | 1983 |
Indomethacin-ethanol interactions on acute inflammation.
Topics: Animals; Biological Availability; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema | 1983 |
Mechanisms of anti-inflammatory action of dexamethasone: blockade by hydrocortisone mesylate and actinomycin D of the inhibitory effect of dexamethasone on leukocyte infiltration in inflammatory sites.
Topics: Androstenedione; Animals; Dactinomycin; Dexamethasone; Dose-Response Relationship, Drug; Hydrocortis | 1984 |
Factors affecting cystoid macular edema and postoperative inflammation.
Topics: Aged; Cataract Extraction; Eye Diseases; Humans; Hyaluronoglucosaminidase; Indomethacin; Inflammatio | 1984 |
Reduction by dexamethasone of chemotactic activity in inflammatory exudates.
Topics: Animals; Chemotaxis, Leukocyte; Dexamethasone; Exudates and Transudates; Hypersensitivity; Indometha | 1984 |
Host defenses in experimental scrub typhus: inflammatory response of congenic C3H mice differing at the Ric gene.
Topics: Animals; Female; Immunity, Cellular; Immunity, Innate; Indomethacin; Inflammation; Mice; Mice, Inbre | 1981 |
The effect of some antirheumatic drugs in vivo on the response of spleen cells to concanavalin A in rats with chronic inflammation.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Chloroquine; Chronic Disease; Concanavalin A; Female; Go | 1982 |
Penetration and effect of topically applied dimethylsulfoxide or indomethacin on adjuvant arthritis in the rat.
Topics: Administration, Topical; Animals; Arthritis; Arthritis, Experimental; Body Weight; Carbon Radioisoto | 1983 |
A comparison of the ocular anti-inflammatory activity of steroidal and nonsteroidal compounds in the rat.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Drug Evaluation, Preclinical; Eye Diseases; Flurbi | 1983 |
The influence of acetylsalicylic acid, phenylbutazone, indomethacin, and flufenamic acid on the kinetics of leucocytes during acute inflammation.
Topics: Analgesics; Animals; Aspirin; Cell Movement; Flufenamic Acid; Indomethacin; Inflammation; Kinetics; | 1980 |
The effects of NSAID on monosodium-urate (MSU) skin test and on other in vivo skin tests (SK/SD; PHA).
Topics: Anti-Inflammatory Agents; Female; Humans; Indomethacin; Indoprofen; Inflammation; Male; Phytohemaggl | 1980 |
Mononuclear cell modulation of fibroblast procoagulant activity.
Topics: Cells, Cultured; Dinoprostone; Fibroblasts; Humans; Indomethacin; Inflammation; Lymphocyte Activatio | 1982 |
A possible role of arachidonate metabolism in allergic air pouch inflammation in rats. Anti-inflammatory effect of indomethacin and dexamethasone and the level of prostaglandin E2 in the exudate.
Topics: Animals; Arachidonic Acids; Cycloheximide; Dexamethasone; Dinoprostone; Exudates and Transudates; Hy | 1982 |
Further studies on glucametacin in rheumatoid arthritis and in other chronic types of rheumatism.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Capsules; Chronic Disease; Female; Glu | 1981 |
[Comparison of the effect of 3-amino-4-mercapto-6-methylpyridazine with various antiphlogistic agents in rat models of inflammation].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Di | 1982 |
Vascular responses during acute neutrophilic inflammation. Their relationship to in vivo neutrophil emigration.
Topics: Animals; Aspirin; Capillary Permeability; Cell Movement; Chemotactic Factors; Escherichia coli; Hype | 1981 |
The effect of nonsteroidal anti-inflammatory agents on E. coli-induced inflammation.
Topics: Anti-Inflammatory Agents; Aspirin; Capillary Permeability; Dinoprostone; Escherichia coli Infections | 1982 |
Relationship between adherence, chemotaxis and the accumulation of rat polymorphonuclear leukocytes at an inflammatory site.
Topics: Animals; Anti-Inflammatory Agents; Cell Adhesion; Chemotaxis, Leukocyte; Dexamethasone; In Vitro Tec | 1982 |
Effect of nonsteroidal anti-inflammatory agents on immune complex- and chemotactic factor-induced inflammation.
Topics: Animals; Antigen-Antibody Complex; Aspirin; Chemotactic Factors; Dose-Response Relationship, Drug; D | 1982 |
The role of the inflammatory response during tumor growth.
Topics: Animals; Cell Division; Hydrocortisone; Indomethacin; Inflammation; Macrophages; Mice; Neutrophils; | 1982 |
Influence of 2,4-tetra-O-methyl-furfurylidene-sorbitol (MSF) on carrageenan-induced inflammation and anti-inflammatory and toxic effects of indomethacin in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Drug Synergism; Female; Free Radicals; Gastric Mucos | 1982 |
An intrauterine silastic system for the sustained release of indomethacin.
Topics: Animals; Body Weight; Estrus; Female; Indomethacin; Inflammation; Intrauterine Devices; Intrauterine | 1981 |
Comparative study between steroidal and nonsteroidal anti-inflammatory drugs on the mode of their actions on vascular permeability in rat carrageenin-air-pouch inflammation.
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Dexamethasone; Indomethacin; | 1980 |
Burger Award address. Toward more selective antiarthritic therapy.
Topics: Anti-Inflammatory Agents; Arthritis; Humans; Indomethacin; Inflammation; Prostaglandins | 1981 |
Micropuncture measurement of interstitial fluid pressure in rat subcutis and skeletal muscle: comparison to wick-in-needle technique.
Topics: Animals; Extracellular Space; Female; Hyaluronic Acid; Indomethacin; Inflammation; Male; Manometry; | 1981 |
Indomethacin.
Topics: Chemical Phenomena; Chemistry, Physical; Drug Interactions; Eye Diseases; Humans; Indomethacin; Infl | 1981 |
[Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents].
Topics: Animals; Carbon Tetrachloride; Carrageenan; Edema; Ibuprofen; Indomethacin; Inflammation; Lipid Pero | 1981 |
The proliferative and toxic effects of ultraviolet light and inflammation on epidermal pigment cells.
Topics: Animals; Anti-Inflammatory Agents; Cell Division; Dimethyl Sulfoxide; Epidermis; Indomethacin; Infla | 1981 |
The effects of levamisole and D-penicillamine on some inflammatory models in vivo and on PG production in vitro.
Topics: Animals; Disease Models, Animal; Edema; In Vitro Techniques; Indomethacin; Inflammation; Leukocytes; | 1981 |
The influence of experimental hypo- and hyperthyroid states on acute and chronic inflammatory reactions: modified response to non-steroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dose-Response Relationship, Drug; Edema; | 1981 |
Urinary excretion of vanillylmandelic acid and effect of some anti-inflammatory drugs in cotton pellet inflammation.
Topics: Animals; Anti-Inflammatory Agents; Gossypium; Indomethacin; Inflammation; Male; Prednisolone; Rats; | 1981 |
The modulation of inflammation by the acute phase reaction in adjuvant arthritis in rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Aspirin; Blood Proteins; Blood Sedimentation; Dexametha | 1981 |
Secretion of a hyperemia-inducing moiety by mitogen or glycogen stimulated mononuclear inflammatory cells of sheep and rabbit.
Topics: Animals; Cells, Cultured; Concanavalin A; Culture Media; Dexamethasone; Female; Glycogen; Guinea Pig | 1980 |
Anti-inflammatory action of topical indomethacin.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Aqueous Humor; Disease Models, Animal; E | 1980 |
Characteristics of prostaglandin E1 potentiation of inflammatory activity of some agents.
Topics: Adenosine; Animals; Bradykinin; Carrageenan; Drug Synergism; Edema; Histamine; Indomethacin; Inflamm | 1980 |
Influence of indomethacin and other anti-inflammatory drugs on mobilization and production of neutrophils: studies with carrageenan-induced inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Bone Marrow; Carrageenan; Cell Migration Inhibition; Dexamethason | 1980 |
Stereology of inflammatory connective tissue infiltrates in oral mucosa.
Topics: Animals; Connective Tissue; Dogs; Gingiva; Gingivitis; Indomethacin; Inflammation; Microscopy, Elect | 1980 |
The diagnosis and management of scleritis.
Topics: Eye Diseases; Humans; Indomethacin; Inflammation; Necrosis; Oxyphenbutazone; Pain; Sclera | 1980 |
Effect of indomethacin-coated posterior chamber intraocular lenses on postoperative inflammation and posterior capsule opacification.
Topics: Animals; Biocompatible Materials; Blood-Aqueous Barrier; Delayed-Action Preparations; Epithelium; In | 1995 |
Toxicodynamic analysis of cough and inflammatory reactions by angiotensin-converting enzyme inhibitors in guinea pig.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cough; Cyclooxygenase Inhibitors; Enalaprilat; Fe | 1995 |
Inhibitory action of indomethacin on neutrophil infiltration in monosodium urate-induced pleurisy in rats.
Topics: Administration, Oral; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; | 1995 |
Bradykinin-induced airway inflammation. Contribution of sensory neuropeptides differs according to airway site.
Topics: Animals; Asthma; Atropine; Bradykinin; Capillary Permeability; Dipeptides; Evans Blue; Guinea Pigs; | 1994 |
Influence of anti-inflammatory treatments on experimental infection of rats with Fasciola hepatica: changes in serum levels of inflammatory markers during the early stages of fasciolosis.
Topics: Acute-Phase Proteins; Analysis of Variance; Animals; Antibodies, Helminth; Antibody Formation; Antig | 1994 |
Effect of nonapeptide fragments of uteroglobin and lipocortin I on oedema and mast cell degranulation.
Topics: Animals; Annexin A1; Aristolochic Acids; Carrageenan; Cell Degranulation; Chlorpheniramine; Dexameth | 1994 |
Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Aspirin; Cell Adhesion; Cell Adhesion Molecul | 1995 |
Nitric oxide and the cyclooxygenase pathway.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bradykinin; Dinoprostone; Enzyme Induction; Escherich | 1995 |
The pharmacological modulation of angiogenesis in chronic granulomatous inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cortisone; Dexamethasone | 1995 |
Antinociceptive activity of filenadol on inflammatory pain.
Topics: Analgesics; Animals; Benzoquinones; Codeine; Formaldehyde; Hyperalgesia; Indomethacin; Inflammation; | 1995 |
Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Calcit | 1995 |
OM-89 modulation of chronic inflammation: relevance to clinical use.
Topics: Adjuvants, Immunologic; Animals; Antigens, Bacterial; Chronic Disease; Drug Synergism; Escherichia c | 1995 |
Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage.
Topics: DNA-Binding Proteins; Gene Expression; Heat Shock Transcription Factors; Heat-Shock Proteins; HeLa C | 1995 |
Anti-inflammatory agents inhibit leukocyte accumulation and vascular leakage induced by trypsin and trypsin-digested serum in hamster cheek pouch.
Topics: Animals; Blood; Cheek; Cortisone; Cricetinae; Dextrans; Female; Fluorescein-5-isothiocyanate; Indome | 1993 |
Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists | 1993 |
Endothelin-induced contraction and mediator release in human bronchus.
Topics: Acetylcholine; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Dicarboxylic Acids; Endot | 1993 |
Carrageenin-evoked c-Fos expression in rat lumbar spinal cord: the effects of indomethacin.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Indomethacin; Inflammation; Male; Proto-Onco | 1995 |
Antinociceptive properties of protein C in a model of inflammatory hyperalgesia in rats.
Topics: Animals; Antibodies, Monoclonal; Basal Metabolism; Carrageenan; Disease Models, Animal; Female; Hype | 1995 |
Expression and selective inhibition of constitutive and inducible forms of cyclooxygenase.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase | 1995 |
Indomethacin reduces both Krox-24 expression in the rat lumbar spinal cord and inflammatory signs following intraplantar carrageenan.
Topics: Animals; Carrageenan; Depression, Chemical; DNA-Binding Proteins; Early Growth Response Protein 1; F | 1995 |
Ozone-induced decrease of mouse tracheal potential is not secondary to cellular inflammation.
Topics: Animals; Bronchoalveolar Lavage Fluid; Colchicine; Cyclophosphamide; Electrophysiology; Epithelium; | 1995 |
Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization.
Topics: Analgesia; Animals; Arginine; Carrageenan; Diclofenac; Dinoprostone; Drug Interactions; Enzyme Activ | 1994 |
Involvement of leukotrienes in allergic inflammation in mice.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetophenones; Anaphylaxis; Animals; A | 1994 |
Contribution of leukocyte infiltration to lipoperoxidation occurring in the non-ischemic region of the rat heart submitted to permanent left coronary artery occlusion.
Topics: Animals; Constriction; Coronary Disease; Fluorescent Antibody Technique; Indomethacin; Inflammation; | 1994 |
Influence of 0-(beta-hydroxyethyl)-rutin on the oedema-inhibiting effect of indomethacin.
Topics: Animals; Anticoagulants; Carrageenan; Drug Synergism; Edema; Hydroxyethylrutoside; Indomethacin; Inf | 1994 |
Preclinical antiarthritic activity of matrix metalloproteinase inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Indomethacin; Inflammatio | 1994 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm | 1994 |
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Topics: Abscess; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Gene Expressio | 1994 |
Avarol and avarone, two new anti-inflammatory agents of marine origin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrageenan; Cyclohexenes; Edema | 1994 |
Measurement of interleukin-1 liberation in zymosan air-pouch exudate in mice.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Exudate | 1994 |
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dexa | 1994 |
Effects of prostaglandins and indomethacin on the cellular inflammatory response following surgical trauma in fetal rabbits.
Topics: Animals; Cicatrix; Delayed-Action Preparations; Dinoprost; Dinoprostone; Drug Implants; Female; Fetu | 1993 |
Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. II. Identification of (tissue) macrophages as the IL-1 producing cells and the effect of anti-inflammatory drugs.
Topics: Animals; Cyclosporine; Diffusion Chambers, Culture; Dinoprostone; Dose-Response Relationship, Drug; | 1993 |
Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation.
Topics: 6-Ketoprostaglandin F1 alpha; Air Sacs; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageena | 1993 |
Human colostrum has anti-inflammatory activity in a rat subcutaneous air pouch model of inflammation.
Topics: Animals; Carrageenan; Colostrum; Dexamethasone; Disease Models, Animal; Female; Humans; Indomethacin | 1993 |
The effect of ebselen on polymorphonuclear leukocyte migration to joints in rats with adjuvant arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Experimental; Azoles; Cel | 1993 |
Effect of airway inflammation on smooth muscle shortening and contractility in guinea pig trachealis.
Topics: Aerosols; Animals; Capsaicin; Guinea Pigs; In Vitro Techniques; Indomethacin; Inflammation; Male; Mu | 1993 |
Bradykinin initiates cytokine-mediated inflammatory hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atenolol; Bradykinin; Carrageenan; Cytokines; Dise | 1993 |
Role of type II phospholipase A2 in the inflammatory process of carrageenan-induced pleurisy in rats.
Topics: Animals; Antibodies, Monoclonal; Carrageenan; Indomethacin; Inflammation; Male; Phospholipases A; Ph | 1994 |
Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia.
Topics: Animals; Bradykinin; Dose-Response Relationship, Drug; Hindlimb; Hyperalgesia; Indomethacin; Inflamm | 1993 |
New Alzheimer's therapy suggested.
Topics: Alzheimer Disease; Amyloid; Anti-Inflammatory Agents, Non-Steroidal; Brain; Humans; Indomethacin; In | 1993 |
Effects of nonsteroidal anti-inflammatory drugs on microvascular dynamics.
Topics: Administration, Topical; Animals; Endothelium, Vascular; Ibuprofen; Indomethacin; Inflammation; Leuk | 1993 |
Analgesic effect of Ga-Al-As diode laser irradiation on hyperalgesia in carrageenin-induced inflammation.
Topics: Analgesia; Animals; Carrageenan; Hyperalgesia; Indomethacin; Inflammation; Laser Therapy; Male; Nalo | 1993 |
Time-course of phospholipase A2, eicosanoid release and cellular accumulation in rat immunological air pouch inflammation.
Topics: Acetophenones; Animals; Antigen-Antibody Complex; Arachidonic Acid; Cell Movement; Dexamethasone; Di | 1993 |
Effects of repetitive motion on human fibroblasts.
Topics: Analysis of Variance; Cells, Cultured; Cumulative Trauma Disorders; Dinoprostone; Fibroblasts; Human | 1993 |
Pharmacological and pharmaceutical properties of freeze-dried formulations of egg albumin, indomethacin, olive oil, or fatty acids.
Topics: Administration, Oral; Animals; Biological Availability; Carrageenan; Drug Carriers; Edema; Fatty Aci | 1993 |
Pharmacological studies on cutaneous inflammation induced by ultraviolet irradiation (1): quantification of erythema by reflectance colorimetry and correlation with cutaneous blood flow.
Topics: Animals; Colorimetry; Erythema; Guinea Pigs; Indomethacin; Inflammation; Laser-Doppler Flowmetry; Ma | 1993 |
Gastric toxicity and prostaglandin content in rats dosed with two chemically similar, nonsteroidal anti-inflammatory agents.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhib | 1993 |
Pristane induces an indomethacin inhibitable inflammatory influx of CD4+ T cells and IFN-gamma production in plasmacytoma-susceptible BALB/cAnPt mice.
Topics: Animals; CD4 Antigens; Indomethacin; Inflammation; Interferon-gamma; Interleukin-5; Mice; Mice, Inbr | 1993 |
Macrolide antibiotics as antiinflammatory agents: roxithromycin in an unexpected role.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Croton Oil; Dis | 1993 |
Local delivery of indomethacin by a polyorthoester inhibits reossification of experimental bone defects.
Topics: Animals; Biocompatible Materials; Drug Implants; Indomethacin; Inflammation; Male; Osteogenesis; Pol | 1995 |
Anti-inflammatory activity of Taiwan folk medicine "ham-hong-chho" in rats.
Topics: Animals; Dose-Response Relationship, Drug; Edema; Indomethacin; Inflammation; Male; Medicine, Chines | 1995 |
Differential effects of prednisolone and indomethacin on zymosan-induced inflammation in a modified murine tissue-chamber model.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Exudates a | 1995 |
Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis.
Topics: Animals; Arthritis, Experimental; Base Sequence; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprost | 1996 |
Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Collagenases; Gelatinases; Indomethacin; Infl | 1996 |
Viral infection induces dependence of neuronal M2 muscarinic receptors on cyclooxygenase in guinea pig lung.
Topics: Animals; Antibodies, Viral; Benzoquinones; Cells, Cultured; Cyclooxygenase Inhibitors; Electric Stim | 1996 |
Development of hyperthermia and hyperalgesia following intracerebroventricular administration of endotoxin in the rat: effect of kinin B1 and B2 receptor antagonists.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Fever; Hyperalgesia; Indomethacin; Inflammatio | 1996 |
Lipid peroxidation and lysosomal integrity in different inflammatory models in rats: the effects of indomethacin and naftazone.
Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ca | 1995 |
VIP-antiserum and indomethacin inhibit calcium and bicarbonate secretion by the inflamed feline gallbladder mucosa.
Topics: Animals; Bicarbonates; Biological Transport; Calcium; Cats; Female; Gallbladder; Immune Sera; Indome | 1996 |
Effect of silymarin on different acute inflammation models and on leukocyte migration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Movement; Ear, External; Edema; | 1996 |
Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine.
Topics: Animals; Behavior, Animal; Carrageenan; Cocaine; Conditioning, Operant; Formaldehyde; Indomethacin; | 1996 |
Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cell Division; Cell Wall; | 1996 |
Zymosan-activated plasma induces paw oedema by nitric oxide and prostaglandin production.
Topics: Animals; Arginine; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Enzyme Inhibi | 1997 |
The effect of propolis and its components on eicosanoid production during the inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic Acid; Caffeic Acids; Cyclooxygenase Inh | 1996 |
Possible participation of cyclooxygenase-2 in the recurrence of allergic inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cycloo | 1997 |
Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Arthritis, Experimental; C | 1996 |
Dietary n-3 fatty acids differentially affect sickness behavior in mice during local and systemic inflammation.
Topics: Animals; Anorexia; Behavior, Animal; Body Temperature; Body Weight; Cachexia; Coconut Oil; Fatty Aci | 1997 |
Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Disease Models, Animal; Drug The | 1997 |
The pharmacological profile of mouse hind paw inflammation induced by staphylococcal enterotoxin type A.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Azepines; Capsaicin; Cimetidi | 1997 |
Arachidonic acid induces DNA-fragmentation in human polymorphonuclear neutrophil granulocytes.
Topics: Apoptosis; Arachidonic Acid; Coloring Agents; Cyclooxygenase Inhibitors; DNA Fragmentation; Eicosape | 1997 |
Acute and chronic effects of different bile acids on indomethacin-induced intestinal inflammation.
Topics: Animals; Bile Acids and Salts; Indomethacin; Inflammation; Inflammatory Bowel Diseases; Intestine, S | 1997 |
Persisting sensitization of the behavioural response to formalin-induced injury in the rat through activation of serotonin2A receptors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Dinoprostone; Foot; Formaldehyde | 1997 |
Kinin B2 and B1 receptor-mediated vasoactive effects in rabbit synovium.
Topics: Animals; Bradykinin; Cyclooxygenase Inhibitors; Indomethacin; Inflammation; Microcirculation; Nitric | 1998 |
Distribution of COX-1 and COX-2 in normal and inflamed tissues.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; C | 1997 |
Rat gastric mucosal cells express ICAM-1 and proinflammatory cytokines during indomethacin-induced mucosal injury.
Topics: Animals; Cell Line; Chemokines, CXC; Chemotactic Factors; Cytokines; Gastric Mucosa; Gene Expression | 1998 |
Brain neurotransmission during peripheral inflammation.
Topics: Animals; Cyclooxygenase Inhibitors; Hippocampus; Humans; Indomethacin; Inflammation; Injections, Int | 1998 |
Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 1998 |
Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Disease Models, Animal; Ear Diseases; Edema; Fo | 1998 |
Pharmacological analysis of cyclooxygenase-1 in inflammation.
Topics: Animals; Arthritis, Experimental; Blood Platelets; Carrageenan; Celecoxib; Cyclooxygenase 1; Cycloox | 1998 |
Intramuscular administration of cholera toxin in Balb/c mice induces an inflammatory reaction that is prevented by indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholera Toxin; Indomethacin; Inflammation; Injecti | 1998 |
Anti-inflammatory activity of D-002: an active product isolated from beeswax.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Carrageenan; Fatty Alcoh | 1998 |
Lactulose and neomycin attenuate leukocyte-endothelial cell adhesion in an animal model of inflammatory bowel disease.
Topics: Animals; Anti-Bacterial Agents; Cell Adhesion; Cell Communication; Disease Models, Animal; Endotheli | 1998 |
Amentoflavone, a plant biflavone: a new potential anti-inflammatory agent.
Topics: Administration, Oral; Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents, Non-St | 1998 |
Antiinflammatory actions of cat's claw: the role of NF-kappaB.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Survival; Cells, Cultured; Electrophoresis; Enzym | 1998 |
Bradykinin B1 and B2 receptors, tumour necrosis factor alpha and inflammatory hyperalgesia.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Bradykinin; Bradykinin Receptor Antagonists; Carrage | 1999 |
Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; C | 1999 |
Effect of combination of misoprostol and indomethacin on eicosanoid production in carrageenan-induced air pouch inflammation in rats.
Topics: Analysis of Variance; Animals; Anti-Ulcer Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Respo | 1999 |
Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation.
Topics: Air; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Arachidonic Acids; C | 1999 |
Inducible cyclooxygenase may have anti-inflammatory properties.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; C | 1999 |
Effect of somatostatin on beta-endorphin release in rat experimental chronic inflammation.
Topics: Alpha-Globulins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; beta-Endorphin; Beta-G | 1999 |
Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms.
Topics: Adolescent; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aortic Aneurysm, Abdominal; Apoptosis; Ce | 1999 |
Characterization of the inflammatory response to proteinase-activated receptor-2 (PAR2)-activating peptides in the rat paw.
Topics: Animals; Capillary Permeability; Edema; Indomethacin; Inflammation; Male; Mast Cells; NG-Nitroargini | 1999 |
Indomethacin-induced disturbances in villous microcirculation in the rat ileum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arterioles; Blood Flow Velocity; Humans; Ileum; In | 1999 |
Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.
Topics: Animals; Animals, Newborn; Astrocytes; Axons; Brain Injuries; Cell Movement; Cells, Cultured; Cerebr | 1999 |
Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation.
Topics: Animals; Base Sequence; Carrageenan; Cyclooxygenase 2; Dinoprostone; DNA Primers; Enzyme Induction; | 1999 |
Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carrageenan; Hydrolyzable Tannins; I | 1999 |
Thrombin, but not bradykinin, stimulates proliferation in isolated human osteoblasts, via a mechanism not dependent on endogenous prostaglandin formation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Cell Count; Cell Division; Cells, Cultured; Chr | 1999 |
Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Edema; Hindlimb; Indome | 2000 |
Links between early adrenal function and respiratory outcome in preterm infants: airway inflammation and patent ductus arteriosus.
Topics: Adrenal Insufficiency; Bronchoalveolar Lavage Fluid; Bronchopulmonary Dysplasia; Chronic Disease; Du | 2000 |
Antiinflammatory effects of seaprose-S on various inflammation models.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1999 |
Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase Inhibitors; Disease Models | 2000 |
Genetic factors determine the contribution of leukotrienes to acute inflammatory responses.
Topics: Acute Disease; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Crosses, Genetic; Ear, Extern | 2000 |
Carrageenan-induced thermal hyperalgesia in the mouse: role of nerve growth factor and the mitogen-activated protein kinase pathway.
Topics: Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Flavonoids; | 2000 |
Granulocytopoiesis versus cytokine activities in peritoneal diffusion chamber cultures in the mouse.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Cells, Cultured; Copper; C | 2000 |
[The neurogenic mechanisms of ocular inflammation and their modulation under local treatment with indomethacin].
Topics: Animals; Anterior Chamber; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Capillary Permeab | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line; Cells, Cultured | 2000 |
Cyclooxygenase-2-mediated angiogenesis in carrageenin-induced granulation tissue in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen | 2000 |
Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats.
Topics: Animals; Blotting, Western; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inh | 2001 |
Suppression of adjuvant arthritis of rats by a novel matrix metalloproteinase-inhibitor.
Topics: Amino Acids; Animals; Antineoplastic Agents; Arthritis, Experimental; Biphenyl Compounds; Body Weigh | 2000 |
Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Benzoates; Cell Death; | 2001 |
Transforming growth factor-beta suppresses tumor necrosis factor alpha-induced matrix metalloproteinase-9 expression in monocytes.
Topics: Bucladesine; Cells, Cultured; Cyclic AMP; Dinoprostone; Enzyme Induction; Humans; Indomethacin; Infl | 2001 |
Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adjuvants, Immunologic; Administration, Cutaneous; Animals; Anti-I | 2001 |
Pharmacological modulation of allergic inflammation in the rat airways and association with mast cell heterogeneity.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Antigens; Capillary Permeability; Cyc | 2001 |
Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model.
Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age | 2001 |
Spinal prostaglandins are involved in the development but not the maintenance of inflammation-induced spinal hyperexcitability.
Topics: Action Potentials; Administration, Topical; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | 2001 |
Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cells, Cultured; Cimetidine; Cyclic A | 2001 |
Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Digestive System | 2001 |
Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat.
Topics: Acute Disease; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Cannabinoid Rece | 2002 |
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygen | 2001 |
An investigation of the antiinflammatory effects of an extract from Cladonia rangiformis HOFFM.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Edema; Formaldehyd | 2002 |
Peripheral 5-HT(2A)-receptor-mediated formation of an inhibitor of atrial natriuretic peptide binding involves inflammation.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atrial Natriuretic Factor; Catecholamin | 2002 |
Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation.
Topics: Animals; Biflavonoids; Blotting, Western; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dinoproston | 2002 |
Systemic inflammatory response associated with augmentation and activation of leukocytes in Candida/indomethacin administered mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Bronchoalveolar Lavage Fluid; Ca | 2002 |
Inhibition of prostaglandin synthesis in vivo by nonsteroid anti-inflammatory drugs: evidence for the importance of pharmacokinetics.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Carrageenan; | 1976 |
Separate anti-inflammatory effects of indomethacin, flurbiprofen and benoxaprofen.
Topics: Animals; Benzoxazoles; Flurbiprofen; Indomethacin; Inflammation; Leukocytes; Propionates; Prostaglan | 1977 |
Proceedings: Prostaglandins in burn induced acute oligo-anuria and oedema.
Topics: Animals; Anuria; Burns; Dogs; Edema; Female; Indomethacin; Inflammation; Male; Oliguria; Prostagland | 1975 |
Effect of some mediators of inflammation on cyclic AMP concentrations in the incubated rat mesentery.
Topics: Animals; Bradykinin; Cyclic AMP; Histamine; In Vitro Techniques; Indomethacin; Inflammation; Mesente | 1976 |
On the enzymatic response to injury and its mediators.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Aspirin; Burns; | 1979 |
Calcium pyrophosphate-induced pleurisy in rats: a new model of acute inflammation.
Topics: Animals; Calcium Phosphates; Cyclic AMP; Diphosphates; Disease Models, Animal; Indomethacin; Inflamm | 1975 |
Prostaglandin release from human polymorphonuclear leukocytes.
Topics: Aspirin; Bucladesine; Humans; Indomethacin; Inflammation; Neutrophils; Phagocytosis; Prostaglandins; | 1976 |
Possible relation of prostaglandins to PMN-derived mediators of host metabolic responses to inflammation.
Topics: Amino Acids; Animals; Aspirin; Biological Assay; Bucladesine; Cells, Cultured; Cyclic GMP; Cyclooxyg | 1977 |
Inflammatory reactions induced by ultraviolet irradiation.
Topics: Arachidonic Acids; Cell Differentiation; Cyclic AMP; Erythema; Humans; Indomethacin; Inflammation; M | 1978 |
Comparison of the mediator release from platelets and the development of acute inflammation in rats which lack prostaglandin precursors.
Topics: Animals; Arachidonic Acids; Blood Platelets; Collagen; Fatty Acids, Essential; Indomethacin; Inflamm | 1977 |
Effects of anti-inflammatory drugs on the carrageenin-induced hind paw inflammation of rats deprived of endogenous precursors of prostaglandins.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Dexamethasone; Fatty Acids, Essential; Indo | 1977 |
Peroxidase reactions during prostaglandin biosynthesis and their relationship to inflammation.
Topics: Animals; Arachidonic Acids; Aspirin; Indomethacin; Inflammation; Male; Mass Spectrometry; Peroxidase | 1979 |
Effects of prostaglandins on peripheral nociceptors in acute inflammation.
Topics: Acute Disease; Animals; Blood Pressure; Bradykinin; Cats; Dogs; Female; Indomethacin; Inflammation; | 1979 |
[Indomethacin].
Topics: Chemical Phenomena; Chemistry; Drug Interactions; Humans; Indomethacin; Inflammation; Rheumatic Dise | 1977 |
Pharmacological properties of proquazone.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1978 |
Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation.
Topics: Animals; Arachidonic Acids; Blood Vessels; Bradykinin; Epoprostenol; Indomethacin; Inflammation; Inj | 1979 |
Kinetics of prostaglandin production in various inflammatory lesions, measured in draining lymph.
Topics: Animals; Capillary Permeability; Carrageenan; Escherichia coli; Female; Hypersensitivity; Immunizati | 1979 |
Topical indomethacin in treatment and prevention of intraocular inflammation--with special reference to lens extraction and cystoid macular edema.
Topics: Animals; Edema; Humans; Indomethacin; Inflammation; Intraocular Pressure; Lenses, Intraocular; Macul | 1979 |
Vitrectomy in experimental uveitis. I. Operative technique in rabbits.
Topics: Animals; Indomethacin; Inflammation; Lens, Crystalline; Methods; Postoperative Care; Postoperative C | 1979 |
Macrophages synthesis and release prostaglandins in response to inflammatory stimuli.
Topics: Animals; Cells, Cultured; Indomethacin; Inflammation; Macrophages; Mice; Phagocytosis; Prostaglandin | 1977 |
Platelet aggregability in microvascular haemostasis and the effect of local inflammation.
Topics: Agranulocytosis; Animals; Female; Hemostasis; Indomethacin; Inflammation; Male; Mesentery; Microcirc | 1978 |
Indomethacin: relationship between ulcerogenic and anti-inflammatory properties. I. Effects of an intestinal lesion-preventing fat-free diet on anti-edema and anti-granuloma properties of indomethacin in the rat.
Topics: Animals; Body Weight; Dietary Fats; Edema; Fatty Acids, Essential; Granuloma; Indomethacin; Inflamma | 1978 |
Effect of in vivo treatment by dexamethasone and indometacin on DNA synthesis in rat macrophages in culture stimulated by inflammatory exudate.
Topics: Animals; Cells, Cultured; Dexamethasone; DNA; Exudates and Transudates; In Vitro Techniques; Indomet | 1978 |
Relationship between oedema and plasma exudation in rat paw carrageenin inflammation.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Exudates and Transudates; Indomethaci | 1978 |
Potentiation of the anti-inflammatory and analgesic activity of aspirin by caffeine in the rat.
Topics: Animals; Arthritis, Rheumatoid; Aspirin; Caffeine; Cyclooxygenase Inhibitors; Drug Therapy, Combinat | 1976 |
Antiinflammatory agents and inhibition of ocular prostaglandin synthetase.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Conjunctiva; Cyclooxygenase Inhibitors; Epinephrine; Eye | 1976 |
[Further studies of the action of an anti-inflammatory agent recently used in therapy].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Indomethacin; Inflammation; Phenylbutazone; Rats; Thiazo | 1977 |
Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Dermatitis, Contact; Erythema; Indometha | 1977 |
Indomethacin inhibition of prostaglandin-mediated inflammation following intraocular surgery.
Topics: Animals; Indomethacin; Inflammation; Lens, Crystalline; Ophthalmologic Surgical Procedures; Postoper | 1977 |
Alteration of Hepatic microsomal enzyme systems and the lethal action of non-steroidal anti-arthritic drugs in acute and chronic models of inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Carrageenan; Chr | 1977 |
[Influence of inflammation on prostaglandin metabolism in rat skin (author's transl)].
Topics: Animals; Arachidonic Acids; Burns; Dinitrochlorobenzene; Indomethacin; Inflammation; Male; Prostagla | 1977 |
Effects of indomethacin on prostaglandin levels and leucocyte migration in an inflammatory exudate in vivo [proceedings].
Topics: Animals; Exudates and Transudates; Indomethacin; Inflammation; Leukocyte Count; Leukocytes; Prostagl | 1976 |
Pathway to adjuvant arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Disease Models, Animal; Foot; Indomethacin; Inflammatio | 1976 |
Quantitative studies of the pathway to acute carrageenan inflammation.
Topics: Acute Disease; Animals; Carrageenan; Chemotaxis; Cyproheptadine; Disease Models, Animal; Edema; Indo | 1976 |
Platelets, prostaglandins and inflammation.
Topics: Animals; Blood Cell Count; Blood Platelets; Exudates and Transudates; Female; Immune Sera; Indometha | 1976 |
The role of prostaglandins in chemically induced inflammation.
Topics: Adenosine Triphosphate; Animals; Capillary Permeability; Dose-Response Relationship, Drug; Histamine | 1976 |
Some pharmacological and toxicological studies on ketoprofen.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzophenones; Fever; Guinea Pigs; Indometha | 1976 |
Inflammatory disease and its control in rheumatic disorders.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Female; Gout; Hum | 1975 |
Some biological properties of flurbiprofen, an anti-inflammatory, analgesic and antipyretic agent.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Cap | 1975 |
Correlation of anti-inflammatory activity with inhibition of prostaglandin synthesis activity of nonsteroidal anti-estrogens and estrogens (38532).
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Clomiphene; Diethylamines; Diethylstilbestrol; Estro | 1975 |
Proceedings: Effects of non-steroidal anti-inflammatory compounds on endotoxin-induced ocular inflammation.
Topics: Animals; Eye Diseases; Indomethacin; Inflammation; Rabbits | 1975 |
Mechanisms of concanavalin A-induced inflammation in the rat.
Topics: Animals; Aspirin; Concanavalin A; Indomethacin; Inflammation; Kinins; Male; Prostaglandins; Rats; Ra | 1975 |
Inhibition of prostaglandin biosynthesis as the mechanism of analgesia of aspirin-like drugs in the dog knee joint.
Topics: Analgesia; Animals; Aspirin; Blood Pressure; Bradykinin; Carrageenan; Depression, Chemical; Dogs; Fe | 1975 |
Dichotomy in response to indomethacin in UV-C and UV-B induced ultraviolet light inflammation.
Topics: Adult; Erythema; Female; Humans; Indomethacin; Inflammation; Injections, Intradermal; Male; Prostagl | 1975 |
Are platelets important in inflammation?
Topics: Animals; Blood Platelets; Carrageenan; Edema; Female; Immune Sera; Indomethacin; Inflammation; Passi | 1975 |
Characteristic features of actinomycin D-induced paw inflammation of the rat.
Topics: Acid Phosphatase; Animals; Aspirin; Capillary Permeability; Dactinomycin; Dose-Response Relationship | 1975 |
[Letter: Indomethacin and fracture healing. Risk of delayed healing and development of pseudarthrosis].
Topics: Animals; Cell Differentiation; Fractures, Bone; Humans; Indomethacin; Inflammation; Male; Middle Age | 1976 |
Experimental inflammation induced by naturally occurring microcrystalline calcium salts.
Topics: Animals; Anti-Inflammatory Agents; Calcium; Calcium Phosphates; Carrageenan; Colchicine; Copper; Dis | 1976 |
Proinflammatory cytokines tumor necrosis factor-alpha and IL-6, but not IL-1, down-regulate the osteocalcin gene promoter.
Topics: Cell Line; Cholecalciferol; Cytotoxicity, Immunologic; Dinoprostone; Gene Expression Regulation; Gen | 1992 |
Measurement of MPO activity as model for detection of granulocyte infiltration in different tissues.
Topics: Animals; Carrageenan; Dexamethasone; Ear; Edema; Guinea Pigs; Hindlimb; Indomethacin; Inflammation; | 1992 |
Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin.
Topics: Adult; Axons; Bradykinin; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomet | 1992 |
A sensitive and relevant model for evaluating anti-inflammatory activity-papaya latex-induced rat paw inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Mod | 1992 |
Differences in proinflammatory activity of several immunomodulatory derivatives of muramyl dipeptide (MDP) with special reference to the mechanism of the MDP effects.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Edema; Foot; Indomethacin; Infla | 1992 |
Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid): comparison with indomethacin.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal | 1992 |
The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia.
Topics: Animals; Carrageenan; Indomethacin; Inflammation; Interleukin-1; Interleukin-6; Interleukin-8; Male; | 1992 |
Antiinflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Comparative studies with indomethacin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Carrageenan; Dige | 1992 |
Comparative studies on inflammatory reactions induced by non-immunological and immunological stimuli in an air pouch and in a carboxymethyl cellulose (CMC)-induced inflammatory pouch.
Topics: Air Sacs; Animals; Carboxymethylcellulose Sodium; Dexamethasone; Hypersensitivity, Delayed; Indometh | 1992 |
Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: inhibition by indomethacin.
Topics: Animals; Ascitic Fluid; Dinoprostone; Dose-Response Relationship, Drug; Indomethacin; Inflammation; | 1992 |
A uniform alteration in serum lipid metabolism occurring during inflammation in mice.
Topics: Animals; Cholesterol; Dexamethasone; Hot Temperature; Indomethacin; Inflammation; Lipids; Male; Mice | 1992 |
Tumour necrosis factor production in a rat airpouch model of inflammation: role of eicosanoids.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Indomethacin; Inflammation | 1991 |
Downward regulation of neutrophil infiltration by endogenous histamine without affecting vascular permeability responses in air-pouch-type carrageenin inflammation in rats.
Topics: Anaphylaxis; Animals; Capillary Permeability; Carrageenan; Disease Models, Animal; Histamine; Histam | 1991 |
Inhibition of prostaglandin production in the inflammatory tissue by loxoprofen-Na, an anti-inflammatory prodrug.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cells, | 1991 |
Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Electrophysiology; Foot; Formaldehyde; | 1991 |
Role of inflammatory responses in initiation of atherosclerosis: effects of anti-inflammatory drugs on cuff-induced leukocyte accumulation and intimal thickening of rabbit carotid artery.
Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Carotid Arteries; Cell Adhesion; Cell Movement; | 1991 |
Antigen-presenting cells in essential fatty acid-deficient murine epidermis: keratinocytes bearing class II (Ia) antigens may potentiate the accessory cell function of Langerhans cells.
Topics: Animals; Antigen-Presenting Cells; Cells, Cultured; Cytokines; Epidermis; Fatty Acids, Essential; Hi | 1991 |
Induction of local inflammation by recombinant human platelet factor 4 in the mouse.
Topics: Animals; Dose-Response Relationship, Drug; Female; Indomethacin; Inflammation; Leukocytes, Mononucle | 1991 |
Effects of indomethacin on prostaglandin E2 and thromboxane B2 contents of tracheal lavage fluids in premature infants.
Topics: Body Fluids; Cyclooxygenase Inhibitors; Dinoprostone; Ductus Arteriosus, Patent; Humans; Indomethaci | 1991 |
Inhibition of acute inflammation in the periphery by central action of salicylates.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dexamethasone; Female; Indomethacin; Infl | 1991 |
Characteristics and modulation of dithranol (anthralin)-induced skin irritation in the mouse ear model.
Topics: Administration, Topical; Adrenal Cortex Hormones; Animals; Anthralin; Anti-Inflammatory Agents, Non- | 1991 |
Prevention of nickel subsulfide carcinogenesis by local administration of Mycobacterium bovis antigen in male F344/NCr rats.
Topics: Animals; Antigens, Bacterial; Carcinogens; Hydrocortisone; Indomethacin; Inflammation; Injections, I | 1991 |
Steroid-saving potency of nonsteroidal antiinflammatory agents--a reevaluation with the new agent CGP 28238 in rat inflammatory models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dexamethasone; Drug Syner | 1991 |
Clinical application of laser flare-cell meter.
Topics: Acetazolamide; Adult; Age Factors; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous H | 1990 |
Effects of antihistamines on phorbol ester tumor promotion and vascular permeability changes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Capillary Permeability; Cimetidine; Diphenhydramine; Fema | 1990 |
Effects of anti-inflammatory and immunosuppressive drugs on the heterolamellar corneal transplantation in rabbits.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Administration, Topical; Animals; Anti | 1990 |
Inflammatory mediators are involved in the Candida albicans killing activity of human epidermal cells.
Topics: Candida albicans; Dexamethasone; Dinoprostone; Diterpenes; Epidermal Cells; Epidermis; Ginkgolides; | 1990 |
Severe anterior segment inflammation following corneal surgery for keratoconus.
Topics: Adult; Anterior Eye Segment; Cornea; Corneal Edema; Eye Diseases; Humans; Indomethacin; Inflammation | 1990 |
The effect of FUT-175 (Nafamstat Mesilate) on C3a, C4a and C5a generation in vitro and inflammatory reactions in vivo.
Topics: Animals; Benzamidines; Complement C3a; Complement C4a; Complement C5a; Complement Inactivator Protei | 1990 |
Metabolic fate of indometacin farnesil, a prodrug of indomethacin: characteristic biotransformation of indometacin farnesil in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Carrageenan; Hydrolysis; Indome | 1990 |
Inhibitory effect of indomethacin farnesil, a novel antiinflammatory prodrug, on carrageenin-induced inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dinoprostone; Edema; Exudates and Tra | 1990 |
[Mechanism of action of pronase on chronic proliferative inflammation including granuloma angiogenesis in mice].
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Granuloma; Hydrocortisone; Hydroxyproline; Indom | 1986 |
The involvement of histamine, the cyclooxygenase system and the kallikrein-kinin system in acute inflammation generation, demonstrated with the Sephadex model in rats.
Topics: Acute Disease; Animals; Dextrans; Exudates and Transudates; Histamine; Indomethacin; Inflammation; K | 1987 |
Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release.
Topics: Animals; Cricetinae; Cyclooxygenase Inhibitors; Dinoprostone; Histamine; Histamine Release; Hypersen | 1988 |
Induction of a silica air-pouch granuloma in rat.
Topics: Acute-Phase Proteins; Animals; Collagen; Cyclophosphamide; Female; Granuloma; Indomethacin; Inflamma | 1988 |
Endothelin-1 participation in overt and inflammatory pain.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Endothelins; Indomethacin; Inflammation; Injections | 1989 |
Analysis of the effects of cyclooxygenase and lipoxygenase inhibitors on leukocyte accumulation in the inflammatory site.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Cimetidine; Cyclooxygenase Inhibito | 1989 |
Prostaglandin E2 prevents diclofenac-induced enhancement of histamine release and inflammation evoked by in vivo challenge with compound 48/80 in the hamster cheek pouch.
Topics: Animals; Cheek; Diclofenac; Dinoprostone; Guinea Pigs; Histamine Release; Indomethacin; Inflammation | 1989 |
Pharmacological investigation of acute cellular accumulation in immunological air pouch inflammation.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antigens; Aprotinin; Bromelai | 1989 |
Some recombinant human cytokines stimulate glycosaminoglycan synthesis in human synovial fibroblast cultures and inhibit it in human articular cartilage cultures.
Topics: Biological Factors; Cartilage, Articular; Cells, Cultured; Culture Techniques; Cytokines; Fibroblast | 1989 |
N-[(arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene D4 antagonists of novel structure.
Topics: Acetophenones; Animals; Bronchi; Chemical Phenomena; Chemistry; Constriction, Pathologic; Cyclooxyge | 1989 |
Prevention of lens protein-induced ocular inflammation with cyclooxygenase and lipoxygenase inhibitors.
Topics: Animals; Crystallins; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Eye Diseases; Female; Fl | 1989 |
Dual action of prostaglandin E2 in allergic inflammation.
Topics: Animals; Cheek; Cricetinae; Dinoprostone; Hypersensitivity; Indomethacin; Inflammation; Leukocytes; | 1989 |
Eicosanoid regulation of acute intestinal vascular permeability induced by intravenous peptidoglycan-polysaccharide polymers.
Topics: Animals; Capillary Permeability; Colon; Dexamethasone; Female; Hemorrhage; Indomethacin; Inflammatio | 1989 |
Effects of phenylbutazone and indomethacin on the post-operative course following experimental orthopaedic surgery in dogs.
Topics: Animals; Dog Diseases; Dogs; Female; Indomethacin; Inflammation; Male; Phenylbutazone; Postoperative | 1989 |
Effect of the novel non-steroidal antiinflammatory agent N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-one on in vitro generation of some inflammatory mediators.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Humans; Indomethacin; Inflammation; | 1987 |
Effects of proglumetacin maleate and its major metabolites on allergic air pouch inflammation in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Dinoprostone; | 1987 |
Inhibition of leucotriene B4 synthesis by BW 755c does not reduce polymorphonuclear leucocyte (PMNL) accumulation induced by monosodium urate crystals.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 1988 |
Role of bradykinin in the vascular permeability response induced by carrageenin in rats.
Topics: Animals; Bradykinin; Capillary Permeability; Carrageenan; Enzyme Inhibitors; Histamine; Immunoenzyme | 1988 |
Inflammatory mediators involved in antigen-induced airway microvascular leakage in guinea pigs.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Antigens; Bronchi; Capillary | 1988 |
Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man.
Topics: Adult; Animals; Blood Proteins; Chlorpheniramine; Guinea Pigs; Histamine H1 Antagonists; Humans; Ind | 1985 |
Indomethacin-induced intestinal ulcers in rats: effects of salicylazosulfapyridine and dexamethasone.
Topics: Animals; Dexamethasone; Female; Indomethacin; Inflammation; Intestinal Diseases; Rats; Sulfasalazine | 1985 |
The effect of anti-inflammatory and rheumatoid disease modifying drugs on prolonged immune and non-immune inflammation in the six-day air pouch of rats.
Topics: Animals; Anti-Inflammatory Agents; Bordetella pertussis; Carrageenan; Dexamethasone; Disease Models, | 1986 |
Mechanism of the inhibitory action of cyclooxygenase inhibitors on leukocyte infiltration: involvement of endogenous histamine.
Topics: Animals; Cell Movement; Cyclooxygenase Inhibitors; Dinoprostone; Histamine; Histamine H1 Antagonists | 1987 |
Prostaglandin E2 reverses indomethacin-induced enhancement of acute allergic inflammation in the hamster cheek pouch.
Topics: Animals; Cricetinae; Dinoprostone; Indomethacin; Inflammation; Leukocytes; Ovalbumin; Prostaglandins | 1987 |
Pharmacological modulation of localized inflammatory reactions: the nonsteroidal anti-inflammatory drug as an adjunct to therapy.
Topics: Animals; Arthus Reaction; Aspirin; Capillary Permeability; Female; Hemorrhage; Indomethacin; Inflamm | 1988 |
Regulation of macrophage collagenase, prostaglandin, and fibroblast-activating-factor production by anti-inflammatory agents: different regulatory mechanisms for tissue injury and repair.
Topics: Animals; Anti-Inflammatory Agents; Colchicine; Cyclic AMP; Dexamethasone; Dinoprostone; Fibroblast G | 1985 |
Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2.
Topics: Animals; Arachidonate Lipoxygenases; Cell Aggregation; Dinoprostone; In Vitro Techniques; Indomethac | 1985 |
Possible involvement of eicosanoids in the pharmacological action of bromelain.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bromelains; Dinoprostone; Exudates and Transudates; In | 1986 |
Leukocyte recruitment in the subcutaneous sponge implant model of acute inflammation in the rat is not mediated by leukotriene B1.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acute Disease; Animals; Blood Proteins | 1986 |
Ebselen: a new approach to the inhibition of peroxide-dependent inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Azoles; Edema; Female; Indomethacin; Inflammation; | 1987 |
Differential effect of inflammatory stimuli on murine plasma C4 and factor B concentrations.
Topics: Animals; Complement Activating Enzymes; Complement C4; Complement Factor D; Female; H-2 Antigens; In | 1988 |
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition.
Topics: Animals; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Ibuprofen; Imidazoles; Indomethac | 1986 |
The contribution of cyclooxygenase and lipoxygenase products to acute inflammation in the rat.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Flurbiprofen; Indomethacin; | 1986 |
Vascular permeability responses and the role of prostaglandin E2 in an experimental allergic inflammation of air pouch type in rats.
Topics: Animals; Capillary Permeability; Diclofenac; Dinoprostone; Hypersensitivity; Indomethacin; Inflammat | 1986 |
Correlation between mouse skin inflammation induced by arachidonic acid and eicosanoid synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Capillary Permeability; Dermatitis, Contact; Dinoprost | 1986 |
Studies on type II collagen induced arthritis in mice.
Topics: Amyloid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arth | 1986 |
Immunosuppressive actions of prostaglandins and the possible increase in chronic inflammation after cyclo-oxygenase inhibitors.
Topics: Cell Division; Cyclooxygenase Inhibitors; Humans; Indomethacin; Inflammation; Interleukin-2; Monocyt | 1986 |
Activation of polyamine biosynthetic decarboxylases during the acute phase response of rat liver.
Topics: Acute-Phase Reaction; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Enzyme Activation; | 1987 |
Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid. 2nd communication: inhibitory effects on acute inflammation and prostaglandin-related reactions.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Benzopyrans; Benzothiepins; | 1986 |
Analysis of tumor-promoter-induced inflammation in rats: participation of histamine and prostaglandin E2.
Topics: Animals; Capillary Permeability; Dinoprostone; Edema; Histamine; Indomethacin; Inflammation; Lyngbya | 1987 |
Prostaglandin synthesis and early biochemical events in the liver cells during the acute-phase response.
Topics: Acute-Phase Reaction; Animals; Aspirin; Dinoprost; Dinoprostone; Indomethacin; Inflammation; Liver; | 1987 |
Blood coagulation and bone metabolism: some characteristics of the bone resorptive effect of thrombin in mouse calvarial bones in vitro.
Topics: Adrenal Cortex Hormones; Animals; Arachidonic Acid; Arachidonic Acids; Bone and Bones; Bone Matrix; | 1988 |
Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Dexamethasone; Edema; Female; | 1988 |
Is the central arachidonic acid cascade system involved in the development of acute-phase response in rabbits?
Topics: Acute-Phase Reaction; Animals; Arachidonic Acid; Arachidonic Acids; Body Temperature; Cerebral Ventr | 1988 |
[Epigenetic mechanism of tumor promotion. Interrelationship between inflammation and ornithine decarboxylase activity induced in vitro by the carcinogenic 12-O-tetradecanoyl-phorbol-13-acetate].
Topics: Animals; Dexamethasone; Epidermis; Female; Hyperplasia; Indomethacin; Inflammation; Mice; Mice, Inbr | 1988 |
Ex vivo effects of nonsteroidal antiinflammatory drugs on arachidonic acid metabolism in neutrophils from a reverse passive Arthus reaction.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthus Reaction; Calcimycin; Edema; Guanidines; Indome | 1985 |
The effect of fosfosal and acetylsalicylic acid on leukocyte migration and PGE2 concentration in experimentally induced acute inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Migration Inhibition; Dinoprostone; | 1988 |
Indomethacin and other NSAIDs do indeed modulate IgE-dependent late phase oedema in human skin.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Immunoglobulin E; Indomethacin; Inflammation; Skin | 1988 |
[Preliminary study on the effect of 1% indomethacin eyedrops in surgery of glaucoma].
Topics: Adult; Aged; Aged, 80 and over; Female; Glaucoma, Open-Angle; Humans; Indomethacin; Inflammation; Ma | 1988 |
Release of inflammatory mediators by noxious stimuli; effect of neurotropin on the release.
Topics: Animals; Bradykinin; Dinoprostone; Histamine; Indomethacin; Inflammation; Kininogens; Kinins; Male; | 1988 |
Lipid peroxidation, free radicals and experimental inflammation.
Topics: Animals; Diclofenac; Disease Models, Animal; Edema; Free Radicals; Indomethacin; Inflammation; Lipid | 1988 |
Adherence, lipopolysaccharide and mucosal inflammation.
Topics: Animals; Bacterial Adhesion; Endotoxins; Escherichia coli Infections; Glycolipids; Humans; Indometha | 1988 |
Studies on inflammation in mice: dynamics of inflammatory response induced by extract from Escherichia coli and influence of antiinflammatory drugs.
Topics: Animals; Ascitic Fluid; Dexamethasone; Escherichia coli; Indomethacin; Inflammation; Injections, Int | 1988 |
Role of bradykinin generating and degrading systems in the vascular permeability response induced with kaolin in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Capillary Permeability; Captopril; Cr | 1987 |
Differential in vivo effects of indomethacin, ibuprofen, and flurbiprofen on oxygen-dependent killing activities of neutrophils elicited by acute nonimmune inflammation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Indomethacin; Inflammatio | 1988 |
The cellular association of sodium salicylate and indomethacin in peritoneal fluid of ascites bearing mice.
Topics: Administration, Oral; Animals; Ascitic Fluid; Freund's Adjuvant; Indomethacin; Inflammation; Injecti | 1987 |
Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats.
Topics: Animals; Azo Compounds; Bradykinin; Capillary Permeability; Dexamethasone; Guinea Pigs; Histamine; I | 1986 |
Discharge characteristics of receptors with fine afferents from normal and inflamed joints: influence of analgesics and prostaglandins.
Topics: Action Potentials; Afferent Pathways; Alprostadil; Animals; Arthritis; Aspirin; Cats; Dinoprostone; | 1986 |
Effects of acetylsalicylic acid and indomethacin on single groups III and IV sensory units from acutely inflamed joints.
Topics: Afferent Pathways; Animals; Aspirin; Cats; Dinoprostone; Electrophysiology; Female; Indomethacin; In | 1986 |
Pharmacological properties of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal antiinflammatory agent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Fever; Indomethacin; Inflammation; Pain; Piroxicam | 1987 |
Immunomodulation by RS-2131, a new non-steroidal antiinflammatory drug.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Hemolytic Plaque T | 1986 |
Protective effect of indomethacin against exercise-induced injuries in mouse skeletal muscle fibers.
Topics: Animals; Athletic Injuries; Glucosephosphate Dehydrogenase; Glucuronidase; Indomethacin; Inflammatio | 1987 |
[The role of inflammation in the spontaneous elimination of Strongyloides ratti infestation].
Topics: Animals; Chlorpheniramine; Cyproheptadine; Indomethacin; Inflammation; Male; Nematode Infections; Pr | 1986 |
Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dexamethasone; Edema; Indomethacin; Inflammation; Male; | 1987 |
Dissociation between antinociceptive and anti-inflammatory effects of acetylsalicylic acid and indomethacin in the formalin test.
Topics: Animals; Aspirin; Dose-Response Relationship, Drug; Formaldehyde; Hindlimb; Indomethacin; Inflammati | 1986 |
[Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug. (1). Anti-inflammatory effects].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Capillary Permeability; Carrageenan; Ed | 1986 |
Turpentine-induced acute inflammatory response in Gallus gallus: oedema, vascular permeability and effects of non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Chickens; Edema; Indometha | 1986 |
The role of mitochondrial calcium transport during inflammation and the effect of anti-inflammatory drugs.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Biological Trans | 1986 |
Comparative effects of non-steroidal anti-inflammatory drugs, mefenamic acid, metiazinic acid and glucametacin on the inflammatory response induced by subcutaneous implantation of human dental plaque and on the mitotic activity of isoproterenol-stimulated
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dental Plaque; Female; Humans; Indomethacin; Infla | 1986 |
Studies on the effects of non-steroidal and disease modifying agents on cartilage soft tissue interaction in vivo.
Topics: Animals; Anti-Inflammatory Agents; Cartilage; Dexamethasone; Indomethacin; Inflammation; Levamisole; | 1986 |
[Anti-inflammatory effect of topically applied pranoprofen-gel].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Benzopyrans; Capillary Permeability; Ede | 1985 |
Influence of prostaglandin E2 and indomethacin on interferon-gamma production by cultured peripheral blood leukocytes of multiple sclerosis patients and healthy donors.
Topics: Adult; Dinoprostone; Humans; Indomethacin; Inflammation; Interferon-gamma; Leukocytes; Macrophages; | 1985 |
In vivo anti-allergic and anti-inflammatory effects of drugs that inhibit lipoxygenase activity in vitro.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenas | 1985 |
[The anti-inflammatory effect of auranofin].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Auranofin; Aurothiogluco | 1985 |
Phlogistic activity of leukotriene D4 in the mouse.
Topics: Animals; Capillary Permeability; Dose-Response Relationship, Drug; Edema; Extravasation of Diagnosti | 1986 |
Pathology of experimental pulmonary bone marrow embolism. I. Initial lesions of the rabbit lung after intravenous infusion of allogeneic bone marrow with special reference to its pathogenesis.
Topics: Animals; Bone Marrow; Capillary Permeability; Diphenhydramine; Embolism, Fat; Endothelium; Female; I | 1985 |
Indomethacin, (-)-terbutaline (beta 2 agonist), and (+)-terbutaline in acute inflammation induced by repeated ischemia in hamster cheek pouch.
Topics: Animals; Capillary Permeability; Cricetinae; Disease Models, Animal; Female; Indomethacin; Inflammat | 1985 |
Anti-inflammatory activity of S-adenosyl-L-methionine in animal models: possible interference with the eicosanoid system.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Hydrocortisone; Indomethacin; Inflammation; M | 1985 |
Episcleritis associated with familial Mediterranean fever.
Topics: Adult; Familial Mediterranean Fever; Female; Humans; Indomethacin; Inflammation; Male; Sclera; Triam | 1985 |
Effect of ibuprofen and indomethacin on the O2 supply/consumption balance in ischemic rabbit myocardium.
Topics: Animals; Anti-Inflammatory Agents; Coronary Circulation; Coronary Disease; Heart; Ibuprofen; Indomet | 1985 |
Pharmacological analysis of the vascular permeability response in the anaphylactic phase of allergic inflammation in rats.
Topics: Anaphylaxis; Animals; Capillary Permeability; Chromones; Dexamethasone; Histamine; Indomethacin; Inf | 1985 |
Effects of nonsteroid anti-inflammatory agents and some dicoumarol derivatives on platelet aggregation, fibrinolysis and stabilization of cell membrane in vitro.
Topics: Anti-Inflammatory Agents; Aspirin; Blood Platelets; Cell Membrane; Chloroquine; Coumarins; Depressio | 1972 |
Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Burns; Carrageenan; Edema; Histamine H1 Antagonists; Ind | 1973 |
[The mechanism of action of non-steroid anti-inflammatory drugs].
Topics: Animals; Anti-Inflammatory Agents; Blood Proteins; Bradykinin; Carboxy-Lyases; Carrageenan; Depressi | 1971 |
[Experimental findings on the site of action and on pharmacodynamics of cytostatic and antiphlogistic drugs in inflammation].
Topics: Animals; Azathioprine; Cyclophosphamide; Glycosaminoglycans; Granulation Tissue; Hematopoietic Syste | 1972 |
[Influence of various drugs on the tissue permeability. 6. Effect of anti-inflammatory drugs on quantitative changes in connective tissue components in inflamed tissues of filter paper-implanted rats].
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Barbiturates; Benzyl Compounds; Connective | 1973 |
Suppression of inflammation and histidine decarboxylase by protein synthesis inhibitors.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Carrageenan; Cycloheximide; Dactinomycin; Endotoxins; Fema | 1968 |
[Anti-inflammatory drugs].
Topics: Adrenocorticotropic Hormone; Aminobenzoates; Anti-Inflammatory Agents; Dental Pulp Capping; Edema; E | 1971 |
[Efficacy of different antiphlogistic agents with respect to carrageenan-inflammation, compared with other models of inflammation].
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; D | 1971 |
Leukocyte chemotaxis in vivo. II. Analysis of the selective inhibition of neutrophil or mononuclear cell accumulation.
Topics: Animals; Bucladesine; Carrageenan; Chemotaxis; Chloroquine; Chlorpromazine; Chromium Radioisotopes; | 1974 |
Action of rare earth metal complexes on neurogenic as well as on bradykinin-induced inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Antivenins; Blood Coagulation; Bradykinin; Catech | 1970 |
Prostaglandins and anti-inflammatory drugs in the dog knee joint.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Dogs; Indomethacin; Inflammation; Knee Joint; Phenylbuta | 1972 |
A modification of rat adjuvant arthritis for testing antirheumatic drugs.
Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthr | 1972 |
Pain in osteoarthrosis.
Topics: Analgesics; Anti-Inflammatory Agents; Aspirin; Cartilage Diseases; Exercise Therapy; Hip; Humans; Im | 1974 |
[Influence of indomethacin on the content of kininogen in the exudate from cutaneous inflammation induced by cantharidin in humans].
Topics: Cantharidin; Exudates and Transudates; Humans; Indomethacin; Inflammation; Kininogens; Skin Diseases | 1974 |
Prostaglandins in synovial inflammatory disease.
Topics: Arthritis; Aspirin; Hemophilia A; Humans; Indomethacin; Inflammation; Prostaglandins; Synovial Fluid | 1974 |
Blood platelets and the inflammatory process.
Topics: Aspirin; Blood Platelets; Blood Proteins; Capillary Permeability; Hemostasis; Histamine; Humans; Ind | 1974 |
Proceedings: the concomitant release of bradykinin and prostaglandin in the inflammatory response to carrageenin.
Topics: Animals; Bradykinin; Carrageenan; Drug Synergism; Indomethacin; Inflammation; Prostaglandins; Rats; | 1974 |
Proceedings: The effect of indomethacin and depletion of complement on cell migration and prostaglandin levels in carrageenin-induced air bleb inflammation.
Topics: Animals; Carrageenan; Cell Migration Inhibition; Complement System Proteins; Indomethacin; Inflammat | 1974 |
[Biochemical studies on action mechnism of a new anti-inflammatory agent, naproxen (1). Effects of naproxen on changes in connective tissue components due to inflammation].
Topics: Animals; Anti-Inflammatory Agents; Benzyl Compounds; Connective Tissue; Dimethylamines; Female; Gran | 1974 |
][A new method for screening of analgesics applied to heat induced inflammatory pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Burns; Drug Evaluation, Preclinical; Flufenamic Acid; Hab | 1974 |
Platelet aggregation induced by arachidonic acid is accompanied by release of potential inflammatory mediators distinct from PGE2 and PGF2.
Topics: Acetaminophen; Anti-Inflammatory Agents; Aorta; Arachidonic Acids; Aspirin; Biological Assay; Blood | 1973 |
Indomethacin-associated gastrointestinal hemorrhage in a dog.
Topics: Administration, Oral; Animals; Dog Diseases; Dogs; Duodenal Diseases; Female; Gastritis; Gastrointes | 1972 |
Studies on phagocytosis. II. The effect of nonsteroidal anti-inflammatory drugs on phagocytosis and on urate crystal-induced canine joint inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Carbon Isotopes; Dogs; Dose-Respon | 1972 |
Prostaglandins, aspirin-like drugs and the oedema of inflammation.
Topics: Animals; Bradykinin; Carrageenan; Drug Synergism; Edema; Histamine; Indomethacin; Inflammation; Pros | 1973 |
Proceedings: A new approach for studying the anti-rheumatic activity of indomethacin using the homograft reaction as a model for chronic immunologically-mediated inflammation.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Glucocorticoids; Graft Rejection; Immuni | 1974 |
Interaction between 'sensitized lymphocytes' and antigen in vitro. V. Vascular permeability induced by skin-reactive factor.
Topics: Aminocaproates; Animals; Antigens; Aprotinin; Aspirin; Blood Coagulation Tests; Capillary Permeabili | 1972 |
[Immunosuppressive activity of indomethacin].
Topics: Animals; Antibody Formation; Arthritis; Arthritis, Rheumatoid; Haplorhini; Hypersensitivity, Delayed | 1972 |
Studies on the mode of action of non-steroid anti-inflammatory drugs.
Topics: Animals; Aspirin; Cell Movement; Disease Models, Animal; Indomethacin; Inflammation; Leukocytes; Mef | 1972 |
Platelets, prostaglandins, red cells, sedimentation rates, serum and tissue proteins and non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Blood Platelets; Blood Proteins; Blood Sedimentation; Carrageenan | 1972 |
Effect of non-steroid anti-inflammatory drugs on prostaglandin biosynthesis by skin.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Female; In Vitro Techniques; Indomethacin; Inflammation; | 1973 |
Inflammatory response in dogs given intraarticular injection of Mycobacterium butyricum-mineral oil adjuvant.
Topics: Animals; Arthritis; Arthritis, Rheumatoid; Blood Sedimentation; Disease Models, Animal; Dogs; Female | 1973 |
[Influence of various drugs on the tissue permeability. 7. Effect of anti-inflammatory drugs on the changes in mucopolysaccharase activity in inflamed tissues of filter paper-implanted rats].
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Dexamethasone; Enzyme Activation; Female; F | 1973 |
[Anti-complement activity in vitro and in vivo of some non-steroid anti-inflammatory drugs].
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Complement Inactivator Proteins; Flufenamic Acid; Hemoly | 1973 |
Anti-inflammatory mechanism of inflamed-tissue factor.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dialysis; Esterases; Exudates and Transudates; Indom | 1973 |
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 1. On acute inflammation].
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Capillary Permeability; Edema; Electrolytes; Eryth | 1973 |
[Anti-inflammatory action of N-(2,6-dichlorophenyl)-o-aminophenylacetic acid, its sodium salt, N-(2,6-dichlorophenyl)-anthranilic acid and its sodium salt. 2. On subacute inflammation].
Topics: Acute Disease; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Body Weight; Ed | 1973 |
[Comparative assessment of analgetic and anti-inflammatory action of benzydamine and indomethacin in selected internal diseases].
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents; Benzyl Compounds; Dimethylamines; Humans; Imidazo | 1974 |
Effects of benzoquinolizine homologues on proliferative and exudative inflammation.
Topics: Adrenal Glands; Animals; Anti-Inflammatory Agents; Body Weight; Carrageenan; Catecholamines; Chlorpr | 1974 |
Mediators and nonsteroid antiinflammatory drugs in immunologically specific and nonspecific inflammatory processes.
Topics: Adjuvants, Immunologic; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis; Bradykinin; Chlor | 1971 |
[On drug therapy of spondylitis ankylopoetica].
Topics: Humans; Indomethacin; Inflammation; Movement Disorders; Ossification, Heterotopic; Phenylbutazone; P | 1966 |
[Surgico-pharmacological association in the early treatment of rheumatoid arthritis of the knee manifested as chronic inflammation].
Topics: Arthritis, Rheumatoid; Chronic Disease; Humans; Indomethacin; Inflammation; Knee; Synovectomy; Time | 1972 |
Release of lysosomal enzymes in experimental inflammations: effects of anti-inflammatory drugs.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Aspirin; Betamethasone; C | 1972 |
Studies on the antiphlogistic activity of cytostatics.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites; Carrageenan; Chloramphenicol; Cyclophosphamide; | 1972 |
The influence of anti-inflammatory and immunosuppressant drugs on Nystatin induced oedema.
Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis; Aspirin; Azathioprine; Ch | 1971 |
New light on inflammation.
Topics: Animals; Aspirin; Blood Vessels; Dogs; Humans; Indomethacin; Inflammation; Prostaglandins; Rats; Ski | 1971 |
Wy 23205, a new non-steroidal anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Bradykinin; Gastrointestinal Diseases; Guinea | 1971 |
[Anti-inflammatory action of Polfa methindol in experimental studies].
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Dermatitis; Female; Freund's Adjuvant; Guinea Pigs; In | 1971 |
[A comparative study on various antiphlogistics].
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Asbestos; Dextrans; Disease Models, Animal; Dr | 1971 |
Drug treatment of rheumatoid arthritis.
Topics: Acid-Base Equilibrium; Adrenal Cortex Hormones; Aminopyrine; Antineoplastic Agents; Arthritis, Rheum | 1971 |
[Anti-inflammatory effects of clonixin, indomethacin, phenylbutazone and hydrocortisone acetate assayed by CMC pouch method].
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Exudates and Transudates; Hydrocortisone; Indo | 1971 |
[Effect of indomethacin on experimental inflammation in man].
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Arm; Humans; Indomethacin; Inflammation; Lipo | 1971 |
[Effect of indomethacin on postoperative course in orthopedic procedures].
Topics: Adult; Aged; Body Temperature; Edema; Extremities; Female; Hematoma; Humans; Indomethacin; Inflammat | 1971 |
[Results of comparative clinical examinations of antirheumatics: clofezone, indomethacin, phenylbutazone].
Topics: Amides; Anti-Inflammatory Agents; Ethylamines; Humans; Indomethacin; Inflammation; Pain; Phenols; Ph | 1971 |
Objective quantitative estimation of the acute inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Biological Assay; Carbon; Colloids; Female; Hindlimb; Indomethaci | 1969 |
[The pharmacotherapy of rheumatoid diseases (1): a chemical survey].
Topics: Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Humans; Indomethacin; Inflammation; Pyrazol | 1969 |
Plasma bradykininogen levels in adjuvant arthritis and carrageenan inflammation.
Topics: Adjuvants, Immunologic; Animals; Arthritis; Bradykinin; Carrageenan; Hindlimb; Indomethacin; Inflamm | 1969 |
Influence of thyroidectomy and thyroid hormones on adjuvant arthritis in rats.
Topics: Adjuvants, Immunologic; Animals; Arthritis; Indomethacin; Inflammation; Male; Mycobacterium; Rats; S | 1970 |
[Current analgesic anti-inflammatory drugs].
Topics: Analgesics; Aniline Compounds; Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver In | 1970 |
Inhibitory effects of indomethacin, aspirin and certain other drugs on inflammations induced in rat and dog by carrageenan, sodium urate and ellagic acid.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Benzopyrans; Carrageenan; Cellulose; Dogs; Indomethacin; | 1970 |
[Experimental ophthalmic anti-inflammatory activity of some steroid and non-steroid drugs topically applied].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Aspirin; Eye; Eye Diseases; Glucocortico | 1970 |
Pharmacological investigations of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine.
Topics: Acid Phosphatase; Analgesics; Animals; Anti-Inflammatory Agents; Antibody Formation; Aspirin; Blood | 1970 |
Pharmacological studies of a new anti-inflammatory drug, 1-phenylsulfonyl-5,5-diphenylhydantoin (PC-796) in experimental animals. I. Anti-inflammatory, analgesic and anti-pyretic activity.
Topics: Aminopyrine; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Aspirin; Bradykinin; Capill | 1970 |
The local anti-inflammatory action of non-steroidal compounds on the paw oedema caused by kaolin in the rat.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents; Edema; Hindlimb; Indomethacin; Inflammation; Kaolin; | 1967 |
[Nonsteroid anti-inflammatory therapy. II. Research on new anti-inflammatory compounds].
Topics: Animals; Dexamethasone; Indomethacin; Inflammation; Phenylbutazone; Rats | 1967 |
[Nonsteroid anti-inflammatory therapy. 3. Basic research on anti-inflammatory compounds].
Topics: Animals; Indomethacin; Inflammation; Phenylbutazone; Prednisone; Rats; Salicylates | 1967 |
[Nonsteroid anti-inflammatory therapy. IV. Clinical experiences using indomethacin].
Topics: Humans; Indomethacin; Inflammation | 1967 |
[Nonsteroid anti-inflammatory therapy. VI. Comparative effects of anti-inflammatory nonsteroid drugs].
Topics: Humans; Indomethacin; Inflammation; Phenylbutazone | 1967 |
Episcleritis and scleritis. II.
Topics: Corneal Opacity; Eye Diseases; Humans; Indomethacin; Inflammation; Keratitis; Oxyphenbutazone; Predn | 1968 |
[Experiences with an indoleacetic acid derivate (Indomethacin) in the therapy of posttraumatic and postoperative edema].
Topics: Abscess; Cellulitis; Edema; Fractures, Bone; Humans; Indomethacin; Inflammation; Intestinal Neoplasm | 1968 |
The drug inhibition of increased vascular permeability.
Topics: Animals; Blood Vessels; Burns; Capillary Permeability; Chlorpromazine; Digoxin; Diphenhydramine; Ind | 1968 |
[Activity of some derivatives of palmitoylethanolamide on carragenine-induced edema in the rat paw].
Topics: Amino Alcohols; Animals; Carrageenan; Edema; Indomethacin; Inflammation; Palmitic Acids; Rats; Stear | 1968 |
[Inflammation and anti-inflammatory agents. Non-steroid anti-inflammatory drug therapy in various fields--orthopedics].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Indomethacin; Inflamma | 1968 |
[Inflammation and anti-inflammatory agents. Clinical experiences with non-steroid anti-inflammatory drugs in oral surgery].
Topics: Anti-Inflammatory Agents; Bromelains; Chymotrypsin; Humans; Indomethacin; Inflammation; Mouth Diseas | 1968 |
[Clinical evaluation of non-steroid anti-inflammatory drugs].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Flufenamic Acid; Humans; Indomethacin; Inf | 1968 |
[Selection standards for steroid and non-steroid anti-inflammatory drugs].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Humans; Indomethacin; Inflammation; Phenylbutazon | 1968 |
[Anti-inflammatory effects of indomethacin].
Topics: Humans; Indomethacin; Inflammation | 1969 |
Pathological defects in the epiphyseal cartilage of zinc-deficient chicks.
Topics: Animals; Cartilage Diseases; Chickens; Deficiency Diseases; Diet; Epiphyses; Histamine; Hyperplasia; | 1969 |
[Pharmacological and toxicological testing of new anti-inflammatory agent azapropazon=3-dimethylamine-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine].
Topics: Abnormalities, Drug-Induced; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents; Bloo | 1969 |
Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool.
Topics: Animals; Anti-Inflammatory Agents; Burns; Guinea Pigs; Hemolysin Proteins; In Vitro Techniques; Indo | 1965 |
[Action of formalin on the cotton pellet granuloma test].
Topics: Animals; Anti-Inflammatory Agents; Formaldehyde; Gossypium; Granuloma; Indomethacin; Inflammation; M | 1964 |