Page last updated: 2024-10-29

indomethacin and Injuries, Tendon

indomethacin has been researched along with Injuries, Tendon in 12 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"This study evaluated the incidence of symptomatic radioulnar synostosis/heterotopic ossification after distal biceps tendon repair in patients receiving indomethacin prophylaxis."7.85The use of indomethacin in the prevention of postoperative radioulnar synostosis after distal biceps repair. ( Abboud, JA; Costopoulos, CL; Getz, CL; Huttman, D; Lazarus, MD; Ramsey, ML; Sholder, DS; Taras, JP, 2017)
"This study evaluated the incidence of symptomatic radioulnar synostosis/heterotopic ossification after distal biceps tendon repair in patients receiving indomethacin prophylaxis."3.85The use of indomethacin in the prevention of postoperative radioulnar synostosis after distal biceps repair. ( Abboud, JA; Costopoulos, CL; Getz, CL; Huttman, D; Lazarus, MD; Ramsey, ML; Sholder, DS; Taras, JP, 2017)
"Indomethacin (3 mg/kg) was then compared to celecoxib (4."1.32Indomethacin and celecoxib improve tendon healing in rats. ( Aspenberg, P; Bylander, B; Forslund, C, 2003)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's2 (16.67)18.2507
2000's2 (16.67)29.6817
2010's3 (25.00)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Wörner, EA1
Kodde, IF1
Spaans, AJ1
Colic, N1
Hilgersom, N1
van Oost, I1
The, B1
Eygendaal, D1
Yu, YH1
Lee, CH1
Hsu, YH1
Chou, YC1
Yu, PC1
Huang, CT1
Liu, SJ1
Costopoulos, CL1
Abboud, JA2
Ramsey, ML1
Getz, CL1
Sholder, DS1
Taras, JP1
Huttman, D1
Lazarus, MD1
Dimmen, S1
Anakwenze, OA1
Kancherla, VK1
Warrender, W1
Forslund, C1
Bylander, B1
Aspenberg, P1
Cohen, DB1
Kawamura, S1
Ehteshami, JR1
Rodeo, SA1
Thomas, J1
Taylor, D1
Crowell, R1
Assor, D1
Szabo, RM1
Younger, E1
Carlstedt, CA2
Madsén, K1
Wredmark, T1
Struck, H1
Hernández-Richter, J1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Ibuprofen on Postoperative Opiate Medication Use and Shoulder[NCT02588027]100 participants (Anticipated)Interventional2015-10-31Active, not recruiting
Rotator Cuff Tendinopathy: A Randomized and Blinded Comparison of Superficial and Deep Injection Methods[NCT01402011]77 participants (Actual)Interventional2010-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Maximum Pain Score at 9 Months

Participants were asked about pain at rest, at work, doing sports. The maximum pain reported on a scale ranging from 0 (no pain at all) to 10 (extreme pain) was recorded for each participant. Maximum of pain scores rest, work, sport recorded. Calculated as pain at baseline - pain at 9 months. (NCT01402011)
Timeframe: baseline and 9 months

Interventionunits on a scale (Mean)
25% Dextrose in Ligaments and Tendons2.9
.1% Lidocaine in Ligaments and Tendons1.8
.1% Lidocaine Subcutaneous1.3

Change From Baseline of Visual Analog Pain Scale at 3 Months

Subject marks his pain level at rest, at work, doing sports on a 10 cm scale. Maximum of pain scores rest, work, sport recorded. Calculated as pain at baseline - pain at 3 months. VAS scale is from 0 = no pain to 10 = maximum pain (NCT01402011)
Timeframe: baseline and three months

Interventionunits on a scale (Mean)
25% Dextrose in Ligaments and Tendons3.0
.1% Lidocaine in Ligaments and Tendons2.7
.1% Lidocaine Subcutaneous2.7

Nine Month Satisfaction Questionnaire

Phone call asking how satisfied were they with their treatment 10 = extremely satisfied, 0 = extremely dissatisfied ) (NCT01402011)
Timeframe: Nine months after first injection treatment appointment

Interventionunits on a scale (Mean)
25% Dextrose in Ligaments and Tendons6.7
.1% Lidocaine in Ligaments and Tendons4.7
.1% Lidocaine Subcutaneous3.9

Visual Analog Pain Scale 0= no Pain 10 = Maximum Pain

Subject marks his pain level at rest, at work, doing sports on a 10 cm scale. The maximum pain level among the 3 different activities was recorded. (NCT01402011)
Timeframe: 20 minutes before first injection on first day of patient visit

Interventionunits on a scale (Mean)
25% Dextrose in Shoulder Entheses7.3
.1% Lidocaine in Shoulder Entheses6.9
.1% Lidocaine Subcu. Above Shouldr Enth.6.9

Disabilities of the Arm Shoulder and Hand Questionnaire

http://www.dash.iwh.on.ca/assets/images/pdfs/DASH_quest06.pdf 30 questions assessing ability to use shoulder in everyday activities, each question scored 1 to 5, where one is normal, no problem and five is unable to perform. No data was collected at 9 months. The score ranges from 30 to 150. Higher scores represent worse outcomes. (NCT01402011)
Timeframe: 20 minutes before the first injection and at 3 months

,,
Interventionunits on a scale (Mean)
Baseline3 months
.1% Lidocaine in Ligaments and Tendons71.354.7
.1% Lidocaine Subcutaneous69.661
25% Dextrose in Ligaments and Tendons72.461.3

Physical Examination of the Shoulder Scale

From Steven W. Brose, DO, Michael L. Boninger, MD, Bradley Fullerton, MD, Thane McCann, MD, From: Jennifer L. Collinger, BSE, Bradley G. Impink, BSE, Trevor A. Dyson-Hudson, MD Shoulder ultrasound abnormalities, physical examination findings, and pain in manual wheelchair users with spinal cord injury. Arch Phys Med Rehabil 2008 Nov; 89:2086-93, appendix 1 12 parameters of shoulder examination: Biceps tendon/bicipital groove tenderness, Supraspinatus tendon/greater tuberosity tenderness Acromioclavicular joint tenderness Resisted external rotation. Resisted internal rotation. Supraspinatus test. Painful Arc Test. Neer impingement sign. Hawkins-Kennedy impingement sign. O'Brien Active Compression Test for AC Joint Pathology O'Brien Active Compression Test for Labral Pathology impingement sign. each test scored 0 = no pain, 1 = tenderness, 2 = pain. All 12 scores added. Range 0-24. Higher scores = more pathology (NCT01402011)
Timeframe: 20 minutes before first injection on first day of patient visit and at 3 months

,,
Interventionunits on a scale (Mean)
Baseline3 months
.1% Lidocaine in Ligaments and Tendons13.110.7
.1% Lidocaine Subcutaneous1312.9
25% Dextrose in Ligaments and Tendons13.211.4

Rotator Cuff Ultrasound, Ultrasound Shoulder Pathology Rating Scale

"From Brose et al. shoulder ultrasound abnormalities, physical examination findings, and pain in manual wheelchair users with spinal cord injury Arch Phys Med Rehabil 2008 Nov, 89: 2086-93 appendix 2. rates biceps tendinopathy (0-6), supraspinatus tendinopathy (0-5), greater tuberosity the cortical surface (0-3), dynamics supraspinatus impingement (0-3), dynamic subscapularis/ biceps/ coracoid impingement (0-3). The total score ranged from 0 to 20 with higher scores indicating a worse outcome. The change was calculated by taking the final score - the baseline score." (NCT01402011)
Timeframe: 20 minutes before first injection on first day of patient visit and at on average 9.4 months

,,
Interventionunits on a scale (Mean)
Baselinechange at 9.4 +/- 2.2 months
.1% Lidocaine in Ligaments and Tendons4.3-0.6
.1% Lidocaine Subcutaneous4.3-0.6
25% Dextrose in Ligaments and Tendons4.0-0.3

Reviews

1 review available for indomethacin and Injuries, Tendon

ArticleYear
Mechanical and chemical factors in tendon healing. Effects of indomethacin and surgery in the rabbit.
    Acta orthopaedica Scandinavica. Supplementum, 1987, Volume: 224

    Topics: Animals; Biomechanical Phenomena; Collagen; Humans; Indomethacin; Ligaments; Male; Models, Biologica

1987

Trials

1 trial available for indomethacin and Injuries, Tendon

ArticleYear
Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing.
    The American journal of sports medicine, 2006, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Indomethacin; Male; New York City; Pyra

2006
Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing.
    The American journal of sports medicine, 2006, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Indomethacin; Male; New York City; Pyra

2006
Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing.
    The American journal of sports medicine, 2006, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Indomethacin; Male; New York City; Pyra

2006
Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing.
    The American journal of sports medicine, 2006, Volume: 34, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Indomethacin; Male; New York City; Pyra

2006

Other Studies

10 other studies available for indomethacin and Injuries, Tendon

ArticleYear
Three weeks of indomethacin is not superior to 1 week of meloxicam as prophylaxis for heterotopic ossifications after distal biceps tendon repair with a single-incision technique.
    Journal of shoulder and elbow surgery, 2022, Volume: 31, Issue:10

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Humans; Indomethacin; Meloxicam; Middle Aged;

2022
Anti-Adhesive Resorbable Indomethacin/Bupivacaine-Eluting Nanofibers for Tendon Rupture Repair: In Vitro and In Vivo Studies.
    International journal of molecular sciences, 2023, Nov-12, Volume: 24, Issue:22

    Topics: Adhesives; Animals; Bupivacaine; Indomethacin; Nanofibers; Polyglycolic Acid; Rats; Tendon Injuries;

2023
The use of indomethacin in the prevention of postoperative radioulnar synostosis after distal biceps repair.
    Journal of shoulder and elbow surgery, 2017, Volume: 26, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arm Injuries; Cohort Studies; Female; Hamstring Tendons; Hu

2017
Effects of Cox inhibitors on bone and tendon healing.
    Acta orthopaedica. Supplementum, 2011, Volume: 82, Issue:342

    Topics: Animals; Biomechanical Phenomena; Bone Density; Cyclooxygenase Inhibitors; Female; Fracture Healing;

2011
Outcomes of modified 2-incision technique with use of indomethicin in treatment of distal biceps tendon rupture.
    Orthopedics, 2011, Nov-09, Volume: 34, Issue:11

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arm Injuries; Disability Evaluation; Elbow Joi

2011
Indomethacin and celecoxib improve tendon healing in rats.
    Acta orthopaedica Scandinavica, 2003, Volume: 74, Issue:4

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Sectional S

2003
The effect of indomethacin on Achilles tendon healing in rabbits.
    Clinical orthopaedics and related research, 1991, Issue:272

    Topics: Achilles Tendon; Animals; Biomechanical Phenomena; Indomethacin; Male; Rabbits; Random Allocation; T

1991
Effects of indomethacin on adhesion formation after repair of zone II tendon lacerations in the rabbit.
    The Journal of hand surgery, 1990, Volume: 15, Issue:3

    Topics: Animals; Indomethacin; Male; Rabbits; Rotation; Tendon Injuries; Toe Joint; Wound Healing

1990
The influence of indomethacin on tendon healing. A biomechanical and biochemical study.
    Archives of orthopaedic and traumatic surgery. Archiv fur orthopadische und Unfall-Chirurgie, 1986, Volume: 105, Issue:6

    Topics: Animals; Biomechanical Phenomena; Collagen; Indomethacin; Male; Rabbits; Tendon Injuries; Tendons; T

1986
[On the influence of an antipholgistic agent on wound healing in animal experiment].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1967, Volume: 38, Issue:8

    Topics: Animals; Collagen; Indomethacin; Injections, Subcutaneous; Rabbits; Tendon Injuries; Wound Healing;

1967