Page last updated: 2024-10-29

indomethacin and Injuries, Radiation

indomethacin has been researched along with Injuries, Radiation in 9 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours."9.24Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017)
"Indomethacin inhibits UVB erythema but is thought not to influence UVA erythema."9.08The effect of topical indomethacin on ultraviolet-radiation-induced erythema. ( Diffey, BL; Farr, PM; Ibbotson, SH, 1996)
"The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours."5.24Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017)
"Indomethacin inhibits UVB erythema but is thought not to influence UVA erythema."5.08The effect of topical indomethacin on ultraviolet-radiation-induced erythema. ( Diffey, BL; Farr, PM; Ibbotson, SH, 1996)
"Ultraviolet-B-induced erythema (one, two, or four times the minimal erythema dose) was reduced but not abolished by application of 1% indomethacin gel immediately after irradiation of human skin."3.71Ultraviolet-B-induced erythema is mediated by nitric oxide and prostaglandin E2 in combination. ( Belgi, G; Clough, GF; Friedmann, PS; McLoughlin, L; Parslew, R; Rhodes, LE, 2001)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's3 (33.33)18.2507
2000's2 (22.22)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Momo, K1
Nagaoka, H1
Kizawa, Y1
Bukawa, H1
Chiba, S1
Kohda, Y1
Homma, M1
Esposito, E1
Cortesi, R1
Drechsler, M1
Paccamiccio, L1
Mariani, P1
Contado, C1
Stellin, E1
Menegatti, E1
Bonina, F1
Puglia, C1
Gomolin, JE1
Koenekoop, RK1
Ibbotson, SH1
Diffey, BL1
Farr, PM1
Sugihara, T1
Hattori, Y1
Yamamoto, Y1
Qi, F1
Ichikawa, R1
Sato, A1
Liu, MY1
Abe, K1
Kanno, M1
Rhodes, LE1
Belgi, G1
Parslew, R1
McLoughlin, L1
Clough, GF1
Friedmann, PS1
Eaglstein, WH1
Marsico, AR1
Pillsbury, HC1
Webster, WP1
Rosenman, J1
Nicolopoulos, N1
Mantidis, A1
Stathopoulos, E1
Papaodysseas, S1
Kouvaris, J1
Varveris, H1
Papavasiliou, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Radiosensitization With a COX-2 Inhibitor (Celecoxib), With Chemoradiation for Cancer of the Head and Neck[NCT00581971]Phase 1/Phase 230 participants (Actual)Interventional2002-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Response as Evaluated by Recurrence of Diseases

Evaluate the response to concurrent celecoxib, carboplatin, paclitaxel, and radiotherapy in the treatment of locally advanced SSC of the head and neck. Response is determined by local control only, local and distant metastasis, distant metastasis only, second primary, and surgical salvage. (NCT00581971)
Timeframe: 2 years from end of treatment (Radiation therapy)

InterventionParticipants (Number)
Local Control OnlyLocal Control and Distant MetastasisDistant Metastatsis OnlySecondary Primary - Site UnknownSurgical Salvage
Recurrence62123

Toxicity of Celecoxib With Concurrent Weekly Chemotherapy and Radiotherapy in the Treatment of Locally Advanced or Recurrent Squamous Cell Carcinoma of the Head and Neck.

Particpants experiencing Acute Toxicities > Grade 3 (NCT00581971)
Timeframe: 2 years from radiation therapy

Interventionparticipants (Number)
HematologicDermatitisMucositis/Dysphagia
Acute Toxicity12716

Trials

5 trials available for indomethacin and Injuries, Radiation

ArticleYear
Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017, Volume: 25, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents; Drug-Related Side Effects and Adverse Reactions; Female; Head an

2017
Presumed photic retinopathy after cataract surgery: an angiographic study.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1993, Volume: 28, Issue:5

    Topics: Cataract Extraction; Fluorescein Angiography; Flurbiprofen; Follow-Up Studies; Fundus Oculi; Humans;

1993
The effect of topical indomethacin on ultraviolet-radiation-induced erythema.
    The British journal of dermatology, 1996, Volume: 135, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors;

1996
Prostaglandin inhibitor and radiotherapy in advanced head and neck cancers.
    Archives of otolaryngology--head & neck surgery, 1986, Volume: 112, Issue:5

    Topics: Clinical Trials as Topic; Combined Modality Therapy; Double-Blind Method; Head and Neck Neoplasms; H

1986
Prophylactic administration of indomethacin for irradiation esophagitis.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:1

    Topics: Clinical Trials as Topic; Double-Blind Method; Esophagitis; Female; Humans; Indomethacin; Lung Neopl

1985

Other Studies

4 other studies available for indomethacin and Injuries, Radiation

ArticleYear
Cubosome dispersions as delivery systems for percutaneous administration of indomethacin.
    Pharmaceutical research, 2005, Volume: 22, Issue:12

    Topics: Adult; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cr

2005
Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation.
    Circulation, 1999, Aug-10, Volume: 100, Issue:6

    Topics: Acetylcholine; Adult; Aged; Arteries; Calcimycin; Combined Modality Therapy; Cyclooxygenase Inhibito

1999
Ultraviolet-B-induced erythema is mediated by nitric oxide and prostaglandin E2 in combination.
    The Journal of investigative dermatology, 2001, Volume: 117, Issue:4

    Topics: Blister; Dinoprostone; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzy

2001
Dichotomy in response to indomethacin in UV-C and UV-B induced ultraviolet light inflammation.
    The Journal of investigative dermatology, 1975, Volume: 65, Issue:2

    Topics: Adult; Erythema; Female; Humans; Indomethacin; Inflammation; Injections, Intradermal; Male; Prostagl

1975