indomethacin has been researched along with Injuries, Radiation in 9 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours." | 9.24 | Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017) |
| "Indomethacin inhibits UVB erythema but is thought not to influence UVA erythema." | 9.08 | The effect of topical indomethacin on ultraviolet-radiation-induced erythema. ( Diffey, BL; Farr, PM; Ibbotson, SH, 1996) |
| "The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours." | 5.24 | Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy. ( Bukawa, H; Chiba, S; Homma, M; Kizawa, Y; Kohda, Y; Momo, K; Nagaoka, H, 2017) |
| "Indomethacin inhibits UVB erythema but is thought not to influence UVA erythema." | 5.08 | The effect of topical indomethacin on ultraviolet-radiation-induced erythema. ( Diffey, BL; Farr, PM; Ibbotson, SH, 1996) |
| "Ultraviolet-B-induced erythema (one, two, or four times the minimal erythema dose) was reduced but not abolished by application of 1% indomethacin gel immediately after irradiation of human skin." | 3.71 | Ultraviolet-B-induced erythema is mediated by nitric oxide and prostaglandin E2 in combination. ( Belgi, G; Clough, GF; Friedmann, PS; McLoughlin, L; Parslew, R; Rhodes, LE, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Momo, K | 1 |
| Nagaoka, H | 1 |
| Kizawa, Y | 1 |
| Bukawa, H | 1 |
| Chiba, S | 1 |
| Kohda, Y | 1 |
| Homma, M | 1 |
| Esposito, E | 1 |
| Cortesi, R | 1 |
| Drechsler, M | 1 |
| Paccamiccio, L | 1 |
| Mariani, P | 1 |
| Contado, C | 1 |
| Stellin, E | 1 |
| Menegatti, E | 1 |
| Bonina, F | 1 |
| Puglia, C | 1 |
| Gomolin, JE | 1 |
| Koenekoop, RK | 1 |
| Ibbotson, SH | 1 |
| Diffey, BL | 1 |
| Farr, PM | 1 |
| Sugihara, T | 1 |
| Hattori, Y | 1 |
| Yamamoto, Y | 1 |
| Qi, F | 1 |
| Ichikawa, R | 1 |
| Sato, A | 1 |
| Liu, MY | 1 |
| Abe, K | 1 |
| Kanno, M | 1 |
| Rhodes, LE | 1 |
| Belgi, G | 1 |
| Parslew, R | 1 |
| McLoughlin, L | 1 |
| Clough, GF | 1 |
| Friedmann, PS | 1 |
| Eaglstein, WH | 1 |
| Marsico, AR | 1 |
| Pillsbury, HC | 1 |
| Webster, WP | 1 |
| Rosenman, J | 1 |
| Nicolopoulos, N | 1 |
| Mantidis, A | 1 |
| Stathopoulos, E | 1 |
| Papaodysseas, S | 1 |
| Kouvaris, J | 1 |
| Varveris, H | 1 |
| Papavasiliou, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Radiosensitization With a COX-2 Inhibitor (Celecoxib), With Chemoradiation for Cancer of the Head and Neck[NCT00581971] | Phase 1/Phase 2 | 30 participants (Actual) | Interventional | 2002-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Evaluate the response to concurrent celecoxib, carboplatin, paclitaxel, and radiotherapy in the treatment of locally advanced SSC of the head and neck. Response is determined by local control only, local and distant metastasis, distant metastasis only, second primary, and surgical salvage. (NCT00581971)
Timeframe: 2 years from end of treatment (Radiation therapy)
| Intervention | Participants (Number) | ||||
|---|---|---|---|---|---|
| Local Control Only | Local Control and Distant Metastasis | Distant Metastatsis Only | Secondary Primary - Site Unknown | Surgical Salvage | |
| Recurrence | 6 | 2 | 1 | 2 | 3 |
Particpants experiencing Acute Toxicities > Grade 3 (NCT00581971)
Timeframe: 2 years from radiation therapy
| Intervention | participants (Number) | ||
|---|---|---|---|
| Hematologic | Dermatitis | Mucositis/Dysphagia | |
| Acute Toxicity | 12 | 7 | 16 |
5 trials available for indomethacin and Injuries, Radiation
| Article | Year |
|---|---|
Assessment of indomethacin oral spray for the treatment of oropharyngeal mucositis-induced pain during anticancer therapy.
Topics: Adult; Aged; Antineoplastic Agents; Drug-Related Side Effects and Adverse Reactions; Female; Head an | 2017 |
Presumed photic retinopathy after cataract surgery: an angiographic study.
Topics: Cataract Extraction; Fluorescein Angiography; Flurbiprofen; Follow-Up Studies; Fundus Oculi; Humans; | 1993 |
The effect of topical indomethacin on ultraviolet-radiation-induced erythema.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; | 1996 |
Prostaglandin inhibitor and radiotherapy in advanced head and neck cancers.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Double-Blind Method; Head and Neck Neoplasms; H | 1986 |
Prophylactic administration of indomethacin for irradiation esophagitis.
Topics: Clinical Trials as Topic; Double-Blind Method; Esophagitis; Female; Humans; Indomethacin; Lung Neopl | 1985 |
4 other studies available for indomethacin and Injuries, Radiation
| Article | Year |
|---|---|
Cubosome dispersions as delivery systems for percutaneous administration of indomethacin.
Topics: Adult; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cr | 2005 |
Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation.
Topics: Acetylcholine; Adult; Aged; Arteries; Calcimycin; Combined Modality Therapy; Cyclooxygenase Inhibito | 1999 |
Ultraviolet-B-induced erythema is mediated by nitric oxide and prostaglandin E2 in combination.
Topics: Blister; Dinoprostone; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzy | 2001 |
Dichotomy in response to indomethacin in UV-C and UV-B induced ultraviolet light inflammation.
Topics: Adult; Erythema; Female; Humans; Indomethacin; Inflammation; Injections, Intradermal; Male; Prostagl | 1975 |