indomethacin has been researched along with Inflammatory Response Syndrome, Systemic in 4 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to compare the efficacy of rectal indomethacin vs placebo in reducing the systemic inflammatory response syndrome (SIRS) score in a high-risk AP population for clinical progression." | 9.41 | Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial. ( Conwell, DL; de-Madaria, E; Greer, P; Hart, PA; Hinton, A; Lee, PJ; Machicado, JD; Mounzer, R; Papachristou, GI; Paragomi, P; Pothoulakis, I; Whitcomb, DC; Yadav, D, 2021) |
| " The aim of this study was to compare the efficacy of rectal indomethacin vs placebo in reducing the systemic inflammatory response syndrome (SIRS) score in a high-risk AP population for clinical progression." | 5.41 | Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial. ( Conwell, DL; de-Madaria, E; Greer, P; Hart, PA; Hinton, A; Lee, PJ; Machicado, JD; Mounzer, R; Papachristou, GI; Paragomi, P; Pothoulakis, I; Whitcomb, DC; Yadav, D, 2021) |
| " The aim of the study is to verify the efficacy of the pharmacological blockade of the systemic inflammatory response syndrome (SIRS) in serious blunt chest injuries, and to identify whether the administration of indomethacin as a cyclooxygenase inhibitor could prevent a multiorgan dysfunction (MODS) and a multiorgan failure (MOF)." | 5.11 | Systemic inflammatory response syndrome (SIRS) in serious chest injuries: is a pharmacological blockade effective? ( Cervinka, V; Havlícek, K; Motycka, V; Siller, J, 2005) |
| " The aim is also to find out if the administration of indomethacin as a cyclooxygenase inhibitor could prevent multiorgan dysfunction (MODS) and multiorgan failure (MOF)." | 5.10 | [Pharmacologic prevention of SIRS (systemic inflammatory response syndrome) in severe thoracic injuries]. ( Fortová, M; Grofová, Z; Havlícek, K; Motycka, V; Siller, J; Vanác, J, 2003) |
| "126 patients with blunt chest injuries were evaluated during 33 months." | 2.72 | [SIRS and serious blunt thoracic injuries]. ( Fortová, M; Grofová, Z; Havlícek, K; Linda, B; Motycka, V; Siller, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Machicado, JD | 1 |
| Mounzer, R | 1 |
| Paragomi, P | 1 |
| Pothoulakis, I | 1 |
| Hart, PA | 1 |
| Conwell, DL | 1 |
| de-Madaria, E | 1 |
| Greer, P | 1 |
| Yadav, D | 1 |
| Whitcomb, DC | 1 |
| Lee, PJ | 1 |
| Hinton, A | 1 |
| Papachristou, GI | 1 |
| Motycka, V | 3 |
| Havlícek, K | 3 |
| Siller, J | 3 |
| Grofová, Z | 2 |
| Vanác, J | 1 |
| Fortová, M | 2 |
| Cervinka, V | 1 |
| Linda, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis[NCT02692391] | Phase 3 | 42 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
CRP levels at 48 hours after enrollment minus CRP levels at enrollment (baseline). A negative number indicates a better outcome (less inflammation). (NCT02692391)
Timeframe: 48 hours
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | -1.43 |
| Indomethacin Suppository | -2.08 |
Enrolled subjects that died. A death indicates a worse outcome. (NCT02692391)
Timeframe: 1 month
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 1 |
| Indomethacin Suppository | 0 |
Including respiratory, renal and cardiovascular failures defined as modified Marshal score of equal and greater than 2. The minimum and maximum values in the modified Marshal score for each organ failure range from 0 to 4 with a higher value representing worse outcomes. (NCT02692391)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 6 |
| Indomethacin Suppository | 3 |
SIRS is a simple clinical score, ranging from 0-4, that utilizes objective, routine clinical parameters (body temperature, heart rate, respiratory rate or arterial carbon dioxide tension and white blood count) that directly reflect the underlying inflammatory response. A lower change in SIRS score (negative number) indicates a better outcome (less inflammation). (NCT02692391)
Timeframe: The change in the SIRS score (48 hours - baseline)
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | -0.96 |
| Indomethacin Suppository | -1 |
4 trials available for indomethacin and Inflammatory Response Syndrome, Systemic
| Article | Year |
|---|---|
Rectal Indomethacin Does Not Mitigate the Systemic Inflammatory Response Syndrome in Acute Pancreatitis: A Randomized Trial.
Topics: Administration, Rectal; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Disease Progression; F | 2021 |
[Pharmacologic prevention of SIRS (systemic inflammatory response syndrome) in severe thoracic injuries].
Topics: Cyclooxygenase Inhibitors; Humans; Indomethacin; Multiple Organ Failure; Premedication; Systemic Inf | 2003 |
Systemic inflammatory response syndrome (SIRS) in serious chest injuries: is a pharmacological blockade effective?
Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studi | 2005 |
[SIRS and serious blunt thoracic injuries].
Topics: Adult; Cyclooxygenase Inhibitors; Humans; Indomethacin; Injury Severity Score; Middle Aged; Respirat | 2006 |