indomethacin has been researched along with Infections, Helicobacter in 26 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs." | 8.02 | Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021) |
| " In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection." | 7.70 | The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000) |
| " pylori infection, indomethacin and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed acetic acid ulcers; and 2) whether or not eradication of the bacteria with drugs at specified times after infection prevents the development of mucosal changes, including gastric adenocarcinoma." | 4.81 | [Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. ( Ebata, M; Keto, Y; Okabe, S, 2001) |
| " speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs." | 4.02 | Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021) |
| " pylori-associated indomethacin-induced gastric ulcers in rats." | 3.73 | Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa. ( Arend, A; Aunapuu, M; Loime, L; Lõivukene, K; Roosaar, P; Selstam, G; Sepp, E; Soom, M; Zilmer, K; Zilmer, M, 2005) |
| " pylori infection, indomethacin, and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed gastric ulcers in Mongolian gerbils." | 3.71 | Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils. ( Ebata, M; Keto, Y; Okabe, S; Tomita, K, 2002) |
| " In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection." | 3.70 | The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000) |
| "In indomethacin and rofecoxib-treated gerbils, the following results were obtained in H pylori-infected group vs H pylori-eradicated group respectively: hyperplasia area of the stomach (mm2): 82." | 1.33 | Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils. ( Chang, CC; Chen, SH; Fang, CL; Hsieh, CR; Lien, GS; Lou, HY; Pan, S, 2005) |
| "Acetic acid ulcers were produced in the rat gastric corpus; non-ulcer rats served as controls." | 1.33 | Cell proliferation in the gastric epithelium of the ulcer rat. ( Helander, HF; Li, H, 2005) |
| "The indomethacin-treated group showed the lowest PGE2 concentration, similar to that of the NS-398 and vehicle-alone treated groups, both without H." | 1.31 | Effects of selective cyclooxygenase-2 inhibitor and non-selective NSAIDs on Helicobacter pylori-induced gastritis in Mongolian gerbils. ( Bhang, CS; Chung, IS; Kim, JI; Kim, SS; Lee, HS; Lee, YS; Park, DH; Song, HJ; Sun, HS; Sung, YJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 21 (80.77) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Siwe, GT | 1 |
| Maharjan, R | 1 |
| Amang, AP | 1 |
| Mezui, C | 1 |
| Zondegoumba, NE | 1 |
| Enow-Orock, GE | 1 |
| Choudhary, MI | 1 |
| Tan, PV | 1 |
| Yanaka, A | 2 |
| Namba, T | 1 |
| Hoshino, T | 1 |
| Suemasu, S | 1 |
| Takarada-Iemata, M | 1 |
| Hori, O | 1 |
| Nakagata, N | 1 |
| Mizushima, T | 1 |
| Elizalde, JI | 1 |
| Mendez, A | 1 |
| Gomez, J | 1 |
| del Rivero, M | 1 |
| Gironella, M | 1 |
| Closa, D | 1 |
| Quintero, E | 1 |
| Pique, JM | 1 |
| Ji, KY | 1 |
| Hu, FJ | 1 |
| Li, AD | 1 |
| Li, J | 1 |
| Tanigawa, T | 1 |
| Watanabe, T | 1 |
| Hamaguchi, M | 1 |
| Sasaki, E | 1 |
| Tominaga, K | 1 |
| Fujiwara, Y | 1 |
| Oshitani, N | 1 |
| Matsumoto, T | 1 |
| Higuchi, K | 1 |
| Arakawa, T | 1 |
| Helander, HF | 2 |
| Poorkhalkali, N | 1 |
| Kanatani, K | 1 |
| Ebata, M | 3 |
| Murakami, M | 1 |
| Okabe, S | 3 |
| Chang, CC | 1 |
| Chen, SH | 1 |
| Lien, GS | 1 |
| Lou, HY | 1 |
| Hsieh, CR | 1 |
| Fang, CL | 1 |
| Pan, S | 1 |
| Arend, A | 1 |
| Loime, L | 1 |
| Roosaar, P | 1 |
| Soom, M | 1 |
| Lõivukene, K | 1 |
| Sepp, E | 1 |
| Aunapuu, M | 1 |
| Zilmer, K | 1 |
| Selstam, G | 1 |
| Zilmer, M | 1 |
| Ebert, MP | 1 |
| Schäfer, C | 1 |
| Chen, J | 1 |
| Hoffmann, J | 1 |
| Gu, P | 1 |
| Kubisch, C | 1 |
| Carl-McGrath, S | 1 |
| Treiber, G | 1 |
| Malfertheiner, P | 1 |
| Röcken, C | 1 |
| Li, H | 1 |
| Suzuki, K | 1 |
| Hayama, M | 1 |
| Nakamura, M | 1 |
| Yamauchi, K | 1 |
| Maruta, F | 1 |
| Miyagawa, S | 1 |
| Ota, H | 1 |
| Thillainayagam, AV | 1 |
| Tabaqchali, S | 1 |
| Warrington, SJ | 1 |
| Farthing, MJ | 1 |
| Stables, R | 1 |
| Campbell, CJ | 1 |
| Clayton, NM | 1 |
| Clitherow, JW | 1 |
| Grinham, CJ | 1 |
| McColm, AA | 1 |
| McLaren, A | 1 |
| Trevethick, MA | 1 |
| Kabir, AM | 1 |
| Shimizu, K | 1 |
| Aiba, Y | 1 |
| Igarashi, M | 2 |
| Takagi, A | 2 |
| Koga, Y | 1 |
| Takahashi, S | 2 |
| Fujita, T | 2 |
| Yamamoto, A | 2 |
| Kim, TI | 1 |
| Lee, YC | 1 |
| Lee, KH | 1 |
| Han, JH | 1 |
| Chon, CY | 1 |
| Moon, YM | 1 |
| Kang, JK | 1 |
| Park, IS | 1 |
| Schraier, M | 1 |
| Petrelli, L | 1 |
| Bonfanti, M | 1 |
| Di Bella, A | 1 |
| Pest, P | 1 |
| Man, F | 1 |
| Adami, J | 1 |
| Tokumoto, M | 1 |
| Slomiany, BL | 1 |
| Piotrowski, J | 1 |
| Slomiany, A | 1 |
| Keto, Y | 2 |
| Bhang, CS | 1 |
| Lee, HS | 1 |
| Kim, SS | 1 |
| Song, HJ | 1 |
| Sung, YJ | 1 |
| Kim, JI | 1 |
| Chung, IS | 1 |
| Sun, HS | 1 |
| Park, DH | 1 |
| Lee, YS | 1 |
| Futagami, S | 1 |
| Hiratsuka, T | 1 |
| Wada, K | 1 |
| Tatsuguchi, A | 1 |
| Tsukui, T | 1 |
| Miyake, K | 1 |
| Akamatsu, T | 1 |
| Hosone, M | 1 |
| Sakamoto, C | 1 |
| Kobayashi, M | 1 |
| Jiang, X | 1 |
| Hasumi, K | 1 |
| Watanabe, S | 1 |
| Deguchi, R | 1 |
| Miwa, T | 1 |
| Tomita, K | 1 |
2 reviews available for indomethacin and Infections, Helicobacter
| Article | Year |
|---|---|
Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastritis; Gastrointestin | 2017 |
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils].
Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer | 2001 |
1 trial available for indomethacin and Infections, Helicobacter
| Article | Year |
|---|---|
Interrelationships between Helicobacter pylori infection, nonsteroidal antiinflammatory drugs and gastroduodenal disease. A prospective study in healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Cyclodextrins; Double-Blind Meth | 1994 |
23 other studies available for indomethacin and Infections, Helicobacter
| Article | Year |
|---|---|
Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing.
Topics: Acanthaceae; Acetic Acid; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Res | 2021 |
Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Down-Regulation; Endoplasmic Ret | 2010 |
Gastric mucosal blood flow changes in Helicobacter pylori infection and NSAID-induced gastric injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Gastritis; Helicobacter Infections | 2003 |
[Interaction of Helicobacter polyri and indomethacin in gastric mucosa injury of Balb/c mice].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Gastritis; Helicobacter Infections | 2003 |
Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; | 2004 |
Parietal cell density during gastric ulcer healing in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Count; Female; Helicobacte | 2004 |
Effects of indomethacin and rofecoxib on gastric mucosal damage in normal and Helicobacter pylori-infected mongolian gerbils.
Topics: Administration, Oral; Animals; Dinoprostone; Drug Administration Schedule; Drug Synergism; Gastric A | 2004 |
Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Chronic Diseas | 2005 |
Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa.
Topics: Animals; Gastric Mucosa; Glutathione; Helicobacter Infections; Helicobacter pylori; Indomethacin; Li | 2005 |
Protective role of heat shock protein 27 in gastric mucosal injury.
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; | 2005 |
Cell proliferation in the gastric epithelium of the ulcer rat.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Epithelial Cells; | 2005 |
Trefoil factor 2 in gland mucous cell mucin in the mucous gel covering normal or damaged gastric mucosa using the Mongolian gerbil model.
Topics: Animals; Disease Models, Animal; Ethanol; Gastric Mucins; Gastric Mucosa; Gerbillinae; Helicobacter | 2006 |
Gastric anti-secretory, mucosal protective, anti-pepsin and anti-Helicobacter properties of ranitidine bismuth citrate.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Citrates; Dogs; Ethanol; Female; Ferrets; Gastric Acid; Gastric | 1993 |
The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; Chalcone; Chalco | 2000 |
Role of cyclooxygenase-2 in Helicobacter pylori- induced gastritis in Mongolian gerbils.
Topics: Animals; Chemokines; Chemotactic Factors; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhib | 2000 |
Nonsteroidal anti-inflammatory drug-induced acute gastric injury in Helicobacter pylori gastritis in Mongolian gerbils.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Dinoprostone; Gas | 2000 |
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Chronic Disease; Cycloox | 2001 |
[Experimental model of infection of Helicobacter pylori in the mouse. A study of gastric damage caused by indomethacin].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Gastric Mucosa; Helicobact | 2001 |
Up-regulation of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide by aspirin but not indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Disease Models, Animal; Gastri | 2001 |
Effects of selective cyclooxygenase-2 inhibitor and non-selective NSAIDs on Helicobacter pylori-induced gastritis in Mongolian gerbils.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyc | 2002 |
Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2002 |
Analysis of Helicobacter pylori and nonsteroidal anti-inflammatory drug-induced gastric epithelial injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Epithelial Cells; Gastri | 2002 |
Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inh | 2002 |