indomethacin has been researched along with Ileitis in 24 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Ileitis: Inflammation of any segment of the ILEUM and the ILEOCECAL VALVE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We evaluated the role of the pro-inflammatory cytokine TNF-alpha on nitric oxide synthase (NOS) expression in indomethacin-induced jejunoileitis in rats." | 7.76 | TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis. ( Levine, RA; Nandi, J; Saud, B; Yang, ZJ; Zinkievich, JM, 2010) |
| " Ileitis was induced in Sprague-Dawley rats by two injections of indomethacin (7." | 7.71 | Role of intercellular adhesion molecule 1 in indomethacin-induced ileitis. ( Bruewer, M; Cerwinka, WH; Granger, DN; Grisham, MB; Krieglstein, CF; Laroux, FS; Russell, JM; Salter, JW; Schuermann, G, 2001) |
| " Anti-CD54 and anti-CD11b were tested in rats with indomethacin-induced chronic ileitis." | 7.70 | Effect of anti-CD11b (alphaM-MAC-1) and anti-CD54 (ICAM-1) monoclonal antibodies on indomethacin induced chronic ileitis in rats. ( Anthoni, C; Krieglstein, CF; Laukötter, MG; Rijcken, E; Schürmann, G; Senninger, N; Spiegel, HU, 1999) |
| "Ileitis in rats was induced by two subcutaneous injections with indomethacin (7." | 7.70 | Characterization of M cell development during indomethacin-induced ileitis in rats. ( Cichon, C; Domschke, W; Kucharzik, T; Linnepe, M; Lügering, A; Lügering, N; Rautenberg, K; Reichelt, R; Schmidt, MA; Stoll, R, 2000) |
| " The anorexia of indomethacin-induced ulcerative ileitis was compared with that of the well-known anorexia of total parenteral nutrition (TPN)." | 7.69 | Mode of food intake reduction in Lewis rats with indomethacin-induced ulcerative ileitis. ( Holtzapple, PG; Levine, RA; Meguid, MM; Nandi, J; Oler, A; Opara, EI; Veerabagu, MP, 1996) |
| "We previously showed that intravenous total parenteral nutrition supplemented with nucleosides and nucleotides (NS/NT) promoted ulcer healing in rats with indomethacin-induced ileitis." | 7.69 | Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis. ( Levine, RA; Loo, A; Magur, E; Nandi, J; Oler, A; Sukumar, P, 1997) |
| " We evaluated the role of the pro-inflammatory cytokine TNF-alpha on nitric oxide synthase (NOS) expression in indomethacin-induced jejunoileitis in rats." | 3.76 | TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis. ( Levine, RA; Nandi, J; Saud, B; Yang, ZJ; Zinkievich, JM, 2010) |
| "During the early stages of indomethacin-induced ileitis, epithelial barrier damage and abnormal bacterial infiltration into the mucosa occurred in conjunction with initial redistribution of CD103+DC." | 3.74 | Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage. ( Jury, J; Perdue, MH; Porras, M; Silva, MA; Vergara, P, 2008) |
| " We evaluated the relationship between TNF-alpha and iNOS expression in indomethacin-induced jejunoileitis in male Sprague-Dawley rats." | 3.73 | Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression. ( Finocchiaro, S; Levine, RA; Nandi, J; Ong, G; Saud, B, 2005) |
| " Indomethacin-induced acute ileitis led to repression of ASBT in wild-type mice and in the transgenic rat ASBT promoter reporter, while paradoxical activation of ASBT was seen in c-fos-null mice." | 3.73 | c-Fos is a critical mediator of inflammatory-mediated repression of the apical sodium-dependent bile acid transporter. ( Alasio, TM; Chen, F; Dawson, PA; Frankenberg, T; Li, X; Magid, MS; Neimark, E; Shneider, BL; Sinha, J, 2006) |
| " In acetic acid-induced colitis in the rat, levels of malondialdehyde were found to be more markedly reduced with MED15 than with 5-aminosalicylic acid." | 3.72 | Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. ( Belogi, L; Bettelli, E; Mezzadri, CM; Tubaro, E, 2003) |
| " Ileitis was induced in Sprague-Dawley rats by two injections of indomethacin (7." | 3.71 | Role of intercellular adhesion molecule 1 in indomethacin-induced ileitis. ( Bruewer, M; Cerwinka, WH; Granger, DN; Grisham, MB; Krieglstein, CF; Laroux, FS; Russell, JM; Salter, JW; Schuermann, G, 2001) |
| "To assess the role of variations of faecal pH on leucocyte endothelial cell adhesion in indomethacin induced long lasting ileitis in rats." | 3.70 | Leucocyte endothelial cell adhesion in indomethacin induced intestinal inflammation is correlated with faecal pH. ( Arndt, H; Palitzsch, KD; Schölmerich, J, 1998) |
| " The objective of this study was to assess the effect of lactulose (Lac) and neomycin (Neo), both of which are used clinically for changing or reducing intestinal flora, on leukocyte-endothelial cell interaction in an indomethacin (Indo)-induced long-lasting ileitis in Sprague-Dawley rats." | 3.70 | Lactulose and neomycin attenuate leukocyte-endothelial cell adhesion in an animal model of inflammatory bowel disease. ( Arndt, H; Palitzsch, KD; Schölmerich, J, 1998) |
| " Anti-CD54 and anti-CD11b were tested in rats with indomethacin-induced chronic ileitis." | 3.70 | Effect of anti-CD11b (alphaM-MAC-1) and anti-CD54 (ICAM-1) monoclonal antibodies on indomethacin induced chronic ileitis in rats. ( Anthoni, C; Krieglstein, CF; Laukötter, MG; Rijcken, E; Schürmann, G; Senninger, N; Spiegel, HU, 1999) |
| "Ileitis in rats was induced by two subcutaneous injections with indomethacin (7." | 3.70 | Characterization of M cell development during indomethacin-induced ileitis in rats. ( Cichon, C; Domschke, W; Kucharzik, T; Linnepe, M; Lügering, A; Lügering, N; Rautenberg, K; Reichelt, R; Schmidt, MA; Stoll, R, 2000) |
| " The anorexia of indomethacin-induced ulcerative ileitis was compared with that of the well-known anorexia of total parenteral nutrition (TPN)." | 3.69 | Mode of food intake reduction in Lewis rats with indomethacin-induced ulcerative ileitis. ( Holtzapple, PG; Levine, RA; Meguid, MM; Nandi, J; Oler, A; Opara, EI; Veerabagu, MP, 1996) |
| "Two indomethacin injections (48 and 24 hours prior to the experiments) induced a longlasting ileitis in rats." | 3.69 | Role of interleukin 8 on leucocyte-endothelial cell adhesion in intestinal inflammation. ( Arndt, H; Bolanowski, MA; Granger, DN, 1996) |
| "We previously showed that intravenous total parenteral nutrition supplemented with nucleosides and nucleotides (NS/NT) promoted ulcer healing in rats with indomethacin-induced ileitis." | 3.69 | Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis. ( Levine, RA; Loo, A; Magur, E; Nandi, J; Oler, A; Sukumar, P, 1997) |
| "Indomethacin (7." | 1.31 | ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease. ( Anthoni, C; Bennett, CF; Krieglstein, CF; Laukoetter, MG; Mennigen, R; Rijcken, E; Schuermann, G; Senninger, N; Spiegel, HU, 2002) |
| "Patients with colitis or ileocolitis were more likely to suffer from ocular inflammation (23." | 1.28 | Ocular inflammation in Crohn's disease. ( Murray, AD; Salmon, JF; Wright, JP, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (37.50) | 18.2507 |
| 2000's | 12 (50.00) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Noguchi, T | 1 |
| Hidaka, K | 1 |
| Kobayashi, S | 1 |
| Matsumoto, K | 1 |
| Yoshioka, M | 1 |
| Hu, X | 1 |
| Maloney, DJ | 1 |
| Yang, SM | 1 |
| Kato, S | 1 |
| Narimatsu, K | 1 |
| Higashiyama, M | 1 |
| Kurihara, C | 1 |
| Takajo, T | 1 |
| Maruta, K | 1 |
| Yasutake, Y | 1 |
| Sato, H | 1 |
| Okada, Y | 1 |
| Watanabe, C | 1 |
| Komoto, S | 1 |
| Tomita, K | 1 |
| Nagao, S | 1 |
| Miura, S | 1 |
| Hokari, R | 1 |
| Nandi, J | 5 |
| Saud, B | 3 |
| Zinkievich, JM | 2 |
| Yang, ZJ | 1 |
| Levine, RA | 5 |
| Harusato, A | 1 |
| Naito, Y | 1 |
| Takagi, T | 1 |
| Yamada, S | 1 |
| Mizushima, K | 1 |
| Hirai, Y | 1 |
| Horie, R | 1 |
| Inoue, K | 1 |
| Fukumoto, K | 1 |
| Hirata, I | 1 |
| Omatsu, T | 1 |
| Kishimoto, E | 1 |
| Uchiyama, K | 1 |
| Handa, O | 1 |
| Ishikawa, T | 1 |
| Kokura, S | 1 |
| Ichikawa, H | 1 |
| Muto, A | 1 |
| Igarashi, K | 1 |
| Yoshikawa, T | 1 |
| Rijcken, E | 2 |
| Krieglstein, CF | 3 |
| Anthoni, C | 2 |
| Laukoetter, MG | 1 |
| Mennigen, R | 1 |
| Spiegel, HU | 2 |
| Senninger, N | 2 |
| Bennett, CF | 1 |
| Schuermann, G | 2 |
| Tubaro, E | 1 |
| Belogi, L | 1 |
| Mezzadri, CM | 1 |
| Bettelli, E | 1 |
| Lügering, A | 2 |
| Floer, M | 1 |
| Lügering, N | 2 |
| Cichon, C | 2 |
| Schmidt, MA | 2 |
| Domschke, W | 2 |
| Kucharzik, T | 2 |
| Bernardes-Silva, CF | 1 |
| Damião, AO | 1 |
| Sipahi, AM | 1 |
| Laurindo, FR | 1 |
| Iriya, K | 1 |
| Lopasso, FP | 1 |
| Buchpiguel, CA | 1 |
| Lordello, ML | 1 |
| Agostinho, CL | 1 |
| Laudanna, AA | 1 |
| Ong, G | 1 |
| Finocchiaro, S | 1 |
| Neimark, E | 1 |
| Chen, F | 1 |
| Li, X | 1 |
| Magid, MS | 1 |
| Alasio, TM | 1 |
| Frankenberg, T | 1 |
| Sinha, J | 1 |
| Dawson, PA | 1 |
| Shneider, BL | 1 |
| Sido, B | 1 |
| Seel, C | 1 |
| Hochlehnert, A | 1 |
| Breitkreutz, R | 1 |
| Dröge, W | 1 |
| Palma, DT | 1 |
| Silva, MA | 1 |
| Jury, J | 1 |
| Porras, M | 1 |
| Vergara, P | 1 |
| Perdue, MH | 1 |
| Jeanneton, O | 1 |
| Delvaux, M | 1 |
| Frexinos, J | 1 |
| Bueno, L | 1 |
| Veerabagu, MP | 1 |
| Opara, EI | 1 |
| Meguid, MM | 1 |
| Oler, A | 2 |
| Holtzapple, PG | 1 |
| Arndt, H | 3 |
| Bolanowski, MA | 1 |
| Granger, DN | 2 |
| Sukumar, P | 1 |
| Loo, A | 1 |
| Magur, E | 1 |
| Palitzsch, KD | 2 |
| Schölmerich, J | 2 |
| Laukötter, MG | 1 |
| Schürmann, G | 1 |
| Rautenberg, K | 1 |
| Linnepe, M | 1 |
| Reichelt, R | 1 |
| Stoll, R | 1 |
| Salter, JW | 1 |
| Cerwinka, WH | 1 |
| Russell, JM | 1 |
| Bruewer, M | 1 |
| Laroux, FS | 1 |
| Grisham, MB | 1 |
| Banerjee, AK | 1 |
| Marway, JS | 1 |
| Preedy, VR | 1 |
| Peters, TJ | 1 |
| Salmon, JF | 1 |
| Wright, JP | 1 |
| Murray, AD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Free Aminoacids in Saliva as A Diagnostic Biomarker of Periodontal Disease[NCT04642716] | 60 participants (Actual) | Interventional | 2015-04-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 other studies available for indomethacin and Ileitis
| Article | Year |
|---|---|
A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; E1A-Associated p300 Protein; Ileitis; Indomethacin; Ma | 2021 |
Toll-like receptor (TLR) 2 agonists ameliorate indomethacin-induced murine ileitis by suppressing the TLR4 signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Migration Assays, Leukocyte; Cell Movement; C | 2015 |
TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis.
Topics: Animals; Dose-Response Relationship, Drug; Enteritis; Hyperbaric Oxygenation; Ileitis; Ileum; Indome | 2010 |
Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Basic-Leucine Zipper Transcription Factors; Chemok | 2009 |
ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease.
Topics: Animals; Cell Adhesion; Ileitis; Indomethacin; Intercellular Adhesion Molecule-1; Leukocytes; Male; | 2002 |
Impact on the bowel of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug.
Topics: Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; | 2003 |
Characterization of M cell formation and associated mononuclear cells during indomethacin-induced intestinal inflammation.
Topics: Animals; Female; Ileitis; Immunohistochemistry; In Situ Hybridization; Indomethacin; Interleukin-4; | 2004 |
Ursodeoxycholic acid ameliorates experimental ileitis counteracting intestinal barrier dysfunction and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Ileitis; Indomethacin; Int | 2004 |
Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Down-Regulation; Ileitis; | 2005 |
c-Fos is a critical mediator of inflammatory-mediated repression of the apical sodium-dependent bile acid transporter.
Topics: Animals; Blotting, Northern; Caco-2 Cells; Cells, Cultured; Gene Expression; Humans; Ileitis; In Vit | 2006 |
Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation?
Topics: Adult; Animals; Case-Control Studies; Colon; Crohn Disease; Dietary Supplements; Disease Models, Ani | 2006 |
5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blotting, Western; Cyclooxygenase Inhi | 2008 |
Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Blotting, Western; Dendritic Cells; | 2008 |
Desensitization of platelet-activating factor receptors, induced by inflammation in guinea pig ileal smooth muscle cells.
Topics: Acetylcholine; Animals; Cell Survival; Dinoprostone; Diterpenes; Ginkgolides; Guinea Pigs; Ileitis; | 1995 |
Mode of food intake reduction in Lewis rats with indomethacin-induced ulcerative ileitis.
Topics: Animals; Anorexia; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cells, Cultured; Dinoprosto | 1996 |
Role of interleukin 8 on leucocyte-endothelial cell adhesion in intestinal inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Cell Adhesion; Cell Migrat | 1996 |
Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis.
Topics: Animal Feed; Animals; Arginine; Female; Food, Fortified; Ileitis; Indomethacin; Nucleotides; Rats; R | 1997 |
Leucocyte endothelial cell adhesion in indomethacin induced intestinal inflammation is correlated with faecal pH.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Diet; Endothelium, Vascular; Feces; | 1998 |
Lactulose and neomycin attenuate leukocyte-endothelial cell adhesion in an animal model of inflammatory bowel disease.
Topics: Animals; Anti-Bacterial Agents; Cell Adhesion; Cell Communication; Disease Models, Animal; Endotheli | 1998 |
Effect of anti-CD11b (alphaM-MAC-1) and anti-CD54 (ICAM-1) monoclonal antibodies on indomethacin induced chronic ileitis in rats.
Topics: Animals; Antibodies, Monoclonal; Cyclooxygenase Inhibitors; Ileitis; Indomethacin; Inflammatory Bowe | 1999 |
Characterization of M cell development during indomethacin-induced ileitis in rats.
Topics: Animals; Apoptosis; Biomarkers; Cell Movement; Epithelial Cells; Epithelium; Female; Fluorescein-5-i | 2000 |
Role of intercellular adhesion molecule 1 in indomethacin-induced ileitis.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Endothelium; Ileitis; Indomethacin; Interce | 2001 |
Gut protein synthetic studies in a NSAID model of inflammatory bowel disease (IBD).
Topics: Animals; Duodenum; Ileitis; Ileum; Indomethacin; Inflammatory Bowel Diseases; Intestinal Mucosa; Kin | 1991 |
Ocular inflammation in Crohn's disease.
Topics: Adolescent; Adult; Aged; Anterior Eye Segment; Anti-Inflammatory Agents, Non-Steroidal; Child; Colit | 1991 |