indomethacin has been researched along with Hypothermia, Accidental in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antipyretic and hypothermic prodrug dipyrone prevents PGE2 -dependent and -independent fever induced by LPS from Escherichia coli and Tityus serrulatus venom (Tsv) respectively." | 7.80 | Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. ( Aguiar, FA; Assis, DC; Clososki, GC; de Melo, MC; de Souza, GE; Ferreira, SH; Jabor, VA; Kalapothakis, E; Malvar, Ddo C; Vaz, Ade L, 2014) |
| " The hypothermia induced by the lipopolysaccharide was abated in a dose-dependent manner by the administration of indomethacin." | 7.66 | Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. ( Hayaishi, O; Ishikawa, Y; Nakayama, T; Narumiya, S; Ogorochi, T; Ueno, R, 1982) |
| "Intraoperative mild hypothermia is common." | 5.30 | Effect of mild hypothermia on the vascular actions of phenylephrine in rat aortic rings. ( Bernard, C; Kirstetter, P; Lagneau, F; Marty, J, 1999) |
| "The antipyretic and hypothermic prodrug dipyrone prevents PGE2 -dependent and -independent fever induced by LPS from Escherichia coli and Tityus serrulatus venom (Tsv) respectively." | 3.80 | Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. ( Aguiar, FA; Assis, DC; Clososki, GC; de Melo, MC; de Souza, GE; Ferreira, SH; Jabor, VA; Kalapothakis, E; Malvar, Ddo C; Vaz, Ade L, 2014) |
| "The effect of three new derivatives from dehydrocrotonin (DHC-compound I) on gastric damage in different animal models including gastric ulceration induced by a necrotic agent and hypothermic restrained-stress was studied: compound II (produced by reducing the cyclohexenone moiety of DHC with NaBH(4)); compound III (produced by reducing the carbonyls with LiAlH(4)); and compound IV (produced by transforming the lactone moiety into an amide)." | 3.72 | Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives. ( Durán, N; Haun, M; Hiruma-Lima, CA; Melo, PS; Souza-Brito, AR, 2003) |
| " This study was undertaken to elucidate the effects of the COX-inhibitor Indomethacin (INDO) and the selective FLAP inhibitor MK-886 on LPS-induced hypothermia, mortality and increase in production of hypothalamic prostaglandin E(2) (PGE(2)) and leukotriene during endotoxemia." | 3.72 | Involvement of eicosanoids in the hypothermic response to lipopolysaccharide during endotoxemia in rats. ( Azab, AN; Kaplanski, J, 2004) |
| " On the other hand, the non-selective NOS inhibitor L-NAME but not aminoguanidine (a relatively selective inhibitor of iNOS), significantly potentiated the acid secretory and mucosal ulcerogenic responses in the stomach but reduced the duodenal damage in response to hypothermia, the effects being antagonized by co-administration of L-arginine." | 3.70 | Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress. ( Araki, H; Mizoguchi, H; Sugamoto, S; Suzuki, K; Takeuchi, K; Umdeda, M, 1999) |
| " The hypothermia induced by the lipopolysaccharide was abated in a dose-dependent manner by the administration of indomethacin." | 3.66 | Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. ( Hayaishi, O; Ishikawa, Y; Nakayama, T; Narumiya, S; Ogorochi, T; Ueno, R, 1982) |
| "Intraoperative mild hypothermia is common." | 1.30 | Effect of mild hypothermia on the vascular actions of phenylephrine in rat aortic rings. ( Bernard, C; Kirstetter, P; Lagneau, F; Marty, J, 1999) |
| " A dose of 10 mug/kg caused a parallel shift to the right of the log dose-response curve for I." | 1.25 | The antipyretic effect of indomethacin. ( Clark, WG; Cumby, HR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 7 (38.89) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malvar, Ddo C | 1 |
| Aguiar, FA | 1 |
| Vaz, Ade L | 1 |
| Assis, DC | 1 |
| de Melo, MC | 1 |
| Jabor, VA | 1 |
| Kalapothakis, E | 1 |
| Ferreira, SH | 1 |
| Clososki, GC | 1 |
| de Souza, GE | 1 |
| Lkhagvasuren, B | 1 |
| Nakamura, Y | 1 |
| Oka, T | 1 |
| Sudo, N | 1 |
| Nakamura, K | 1 |
| Melo, PS | 1 |
| Durán, N | 1 |
| Hiruma-Lima, CA | 1 |
| Souza-Brito, AR | 1 |
| Haun, M | 1 |
| Azab, AN | 1 |
| Kaplanski, J | 2 |
| Azab, A | 1 |
| Kobal, S | 1 |
| Rubin, M | 1 |
| Singh, VP | 1 |
| Patil, CS | 1 |
| Kumar, M | 1 |
| Kulkarni, SK | 1 |
| Topalian, SL | 1 |
| Ziegler, MM | 1 |
| Ueno, R | 1 |
| Narumiya, S | 1 |
| Ogorochi, T | 1 |
| Nakayama, T | 1 |
| Ishikawa, Y | 1 |
| Hayaishi, O | 1 |
| al-Harbi, MM | 1 |
| Islam, MW | 1 |
| al-Shabanah, OA | 1 |
| al-Gharably, NM | 1 |
| Derijk, RH | 1 |
| Van Kampen, M | 1 |
| Van Rooijen, N | 1 |
| Berkenbosch, F | 1 |
| Stein, EA | 1 |
| Fuller, SA | 1 |
| Edgemond, WS | 1 |
| Campbell, WB | 1 |
| Lagneau, F | 1 |
| Kirstetter, P | 1 |
| Bernard, C | 1 |
| Marty, J | 1 |
| Sartori, NT | 1 |
| Canepelle, D | 1 |
| de Sousa, PT | 1 |
| Martins, DT | 1 |
| Takeuchi, K | 1 |
| Suzuki, K | 1 |
| Araki, H | 1 |
| Mizoguchi, H | 1 |
| Sugamoto, S | 1 |
| Umdeda, M | 1 |
| Nishina, M | 1 |
| Suzuki, M | 1 |
| Clark, WG | 1 |
| Cumby, HR | 1 |
| Chajek-Shaul, T | 1 |
| Barash, V | 1 |
| Weidenfeld, J | 1 |
| Friedman, G | 1 |
| Ziv, E | 1 |
| Shohami, E | 1 |
| Shiloni, E | 1 |
| Parmar, NS | 1 |
| Tariq, M | 1 |
| Ageel, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Thermoregulation Among Individuals With First-episode Psychosis[NCT04369677] | 20 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Hypothermia, Accidental
| Article | Year |
|---|---|
Necrotizing enterocolitis: a review of animal models.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Bacterial Physiological Phenomena; Blood Volume; Bre | 1984 |
17 other studies available for indomethacin and Hypothermia, Accidental
| Article | Year |
|---|---|
Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever.
Topics: Ampyrone; Animals; Antipyretics; Body Temperature; Dinoprostone; Dipyrone; Fever; Hypothalamus; Hypo | 2014 |
Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region.
Topics: Adrenergic beta-3 Receptor Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Body Tem | 2011 |
Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives.
Topics: Animals; Anti-Ulcer Agents; Croton; Diterpenes; Diterpenes, Clerodane; Ethanol; Hydrochloric Acid; H | 2003 |
Involvement of eicosanoids in the hypothermic response to lipopolysaccharide during endotoxemia in rats.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Eicosanoids; Endotoxemia; Fever; Hypoth | 2004 |
Inhibition of prostaglandins does not reduce the cardiovascular changes during endotoxemia in rats.
Topics: Animals; Body Temperature; Dimethyl Sulfoxide; Dinoprostone; Endotoxemia; Heart Rate; Hypothalamus; | 2006 |
Effect of 5-lipoxygenase inhibitor against lipopolysaccharide-induced hypothermia in mice.
Topics: Animals; Colon; Dinoprostone; Female; Hydroxyurea; Hypothalamus; Hypothermia; Hypothermia, Induced; | 2005 |
Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide.
Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Hypothermia; Indomethacin; Injections | 1982 |
Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fish Oils; Gastric Aci | 1995 |
Hypothermia to endotoxin involves reduced thermogenesis, macrophage-dependent mechanisms, and prostaglandins.
Topics: Animals; Body Temperature; Body Temperature Regulation; Colon; Dose-Response Relationship, Drug; End | 1994 |
Physiological and behavioural effects of the endogenous cannabinoid, arachidonylethanolamide (anandamide), in the rat.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Be | 1996 |
Effect of mild hypothermia on the vascular actions of phenylephrine in rat aortic rings.
Topics: Animals; Aorta; Cyclooxygenase Inhibitors; Endothelium, Vascular; Hypothermia; Indomethacin; Nitric | 1999 |
Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Gastric | 1999 |
Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Atropine; Cyclooxygenase Inhibi | 1999 |
Biphasic hypothermia in mice infected with a parasitic nematode, Trichinella spiralis.
Topics: Animals; Blood Glucose; Body Temperature; Cyclooxygenase Inhibitors; Hypothermia; Indomethacin; Male | 2002 |
The antipyretic effect of indomethacin.
Topics: Animals; Body Temperature; Brain; Cats; Cerebral Ventricles; Dose-Response Relationship, Drug; Fever | 1975 |
Lethal hypoglycemia and hypothermia induced by administration of low doses of tumor necrosis factor to adrenalectomized rats.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Blood Glucose; Body Temperature Regulation; Dexamethasone; | 1990 |
Studies on the gastroulcerogenic effects of pylorus ligation, hypothermic restraint stress, aspirin, indomethacin and reserpine in morphine dependent rats.
Topics: Animals; Aspirin; Gastric Acid; Hypothermia; Indomethacin; Ligation; Male; Morphine Dependence; Pylo | 1987 |