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indomethacin and Hypothermia, Accidental

indomethacin has been researched along with Hypothermia, Accidental in 18 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"The antipyretic and hypothermic prodrug dipyrone prevents PGE2 -dependent and -independent fever induced by LPS from Escherichia coli and Tityus serrulatus venom (Tsv) respectively."7.80Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. ( Aguiar, FA; Assis, DC; Clososki, GC; de Melo, MC; de Souza, GE; Ferreira, SH; Jabor, VA; Kalapothakis, E; Malvar, Ddo C; Vaz, Ade L, 2014)
" The hypothermia induced by the lipopolysaccharide was abated in a dose-dependent manner by the administration of indomethacin."7.66Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. ( Hayaishi, O; Ishikawa, Y; Nakayama, T; Narumiya, S; Ogorochi, T; Ueno, R, 1982)
"Intraoperative mild hypothermia is common."5.30Effect of mild hypothermia on the vascular actions of phenylephrine in rat aortic rings. ( Bernard, C; Kirstetter, P; Lagneau, F; Marty, J, 1999)
"The antipyretic and hypothermic prodrug dipyrone prevents PGE2 -dependent and -independent fever induced by LPS from Escherichia coli and Tityus serrulatus venom (Tsv) respectively."3.80Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever. ( Aguiar, FA; Assis, DC; Clososki, GC; de Melo, MC; de Souza, GE; Ferreira, SH; Jabor, VA; Kalapothakis, E; Malvar, Ddo C; Vaz, Ade L, 2014)
"The effect of three new derivatives from dehydrocrotonin (DHC-compound I) on gastric damage in different animal models including gastric ulceration induced by a necrotic agent and hypothermic restrained-stress was studied: compound II (produced by reducing the cyclohexenone moiety of DHC with NaBH(4)); compound III (produced by reducing the carbonyls with LiAlH(4)); and compound IV (produced by transforming the lactone moiety into an amide)."3.72Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives. ( Durán, N; Haun, M; Hiruma-Lima, CA; Melo, PS; Souza-Brito, AR, 2003)
" This study was undertaken to elucidate the effects of the COX-inhibitor Indomethacin (INDO) and the selective FLAP inhibitor MK-886 on LPS-induced hypothermia, mortality and increase in production of hypothalamic prostaglandin E(2) (PGE(2)) and leukotriene during endotoxemia."3.72Involvement of eicosanoids in the hypothermic response to lipopolysaccharide during endotoxemia in rats. ( Azab, AN; Kaplanski, J, 2004)
" On the other hand, the non-selective NOS inhibitor L-NAME but not aminoguanidine (a relatively selective inhibitor of iNOS), significantly potentiated the acid secretory and mucosal ulcerogenic responses in the stomach but reduced the duodenal damage in response to hypothermia, the effects being antagonized by co-administration of L-arginine."3.70Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress. ( Araki, H; Mizoguchi, H; Sugamoto, S; Suzuki, K; Takeuchi, K; Umdeda, M, 1999)
" The hypothermia induced by the lipopolysaccharide was abated in a dose-dependent manner by the administration of indomethacin."3.66Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide. ( Hayaishi, O; Ishikawa, Y; Nakayama, T; Narumiya, S; Ogorochi, T; Ueno, R, 1982)
"Intraoperative mild hypothermia is common."1.30Effect of mild hypothermia on the vascular actions of phenylephrine in rat aortic rings. ( Bernard, C; Kirstetter, P; Lagneau, F; Marty, J, 1999)
" A dose of 10 mug/kg caused a parallel shift to the right of the log dose-response curve for I."1.25The antipyretic effect of indomethacin. ( Clark, WG; Cumby, HR, 1975)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19904 (22.22)18.7374
1990's7 (38.89)18.2507
2000's5 (27.78)29.6817
2010's2 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Malvar, Ddo C1
Aguiar, FA1
Vaz, Ade L1
Assis, DC1
de Melo, MC1
Jabor, VA1
Kalapothakis, E1
Ferreira, SH1
Clososki, GC1
de Souza, GE1
Lkhagvasuren, B1
Nakamura, Y1
Oka, T1
Sudo, N1
Nakamura, K1
Melo, PS1
Durán, N1
Hiruma-Lima, CA1
Souza-Brito, AR1
Haun, M1
Azab, AN1
Kaplanski, J2
Azab, A1
Kobal, S1
Rubin, M1
Singh, VP1
Patil, CS1
Kumar, M1
Kulkarni, SK1
Topalian, SL1
Ziegler, MM1
Ueno, R1
Narumiya, S1
Ogorochi, T1
Nakayama, T1
Ishikawa, Y1
Hayaishi, O1
al-Harbi, MM1
Islam, MW1
al-Shabanah, OA1
al-Gharably, NM1
Derijk, RH1
Van Kampen, M1
Van Rooijen, N1
Berkenbosch, F1
Stein, EA1
Fuller, SA1
Edgemond, WS1
Campbell, WB1
Lagneau, F1
Kirstetter, P1
Bernard, C1
Marty, J1
Sartori, NT1
Canepelle, D1
de Sousa, PT1
Martins, DT1
Takeuchi, K1
Suzuki, K1
Araki, H1
Mizoguchi, H1
Sugamoto, S1
Umdeda, M1
Nishina, M1
Suzuki, M1
Clark, WG1
Cumby, HR1
Chajek-Shaul, T1
Barash, V1
Weidenfeld, J1
Friedman, G1
Ziv, E1
Shohami, E1
Shiloni, E1
Parmar, NS1
Tariq, M1
Ageel, AM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Thermoregulation Among Individuals With First-episode Psychosis[NCT04369677]20 participants (Anticipated)Observational2023-11-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for indomethacin and Hypothermia, Accidental

ArticleYear
Necrotizing enterocolitis: a review of animal models.
    The Journal of surgical research, 1984, Volume: 37, Issue:4

    Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Bacterial Physiological Phenomena; Blood Volume; Bre

1984

Other Studies

17 other studies available for indomethacin and Hypothermia, Accidental

ArticleYear
Dipyrone metabolite 4-MAA induces hypothermia and inhibits PGE2 -dependent and -independent fever while 4-AA only blocks PGE2 -dependent fever.
    British journal of pharmacology, 2014, Volume: 171, Issue:15

    Topics: Ampyrone; Animals; Antipyretics; Body Temperature; Dinoprostone; Dipyrone; Fever; Hypothalamus; Hypo

2014
Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region.
    The European journal of neuroscience, 2011, Volume: 34, Issue:9

    Topics: Adrenergic beta-3 Receptor Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Body Tem

2011
Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives.
    Journal of ethnopharmacology, 2003, Volume: 87, Issue:2-3

    Topics: Animals; Anti-Ulcer Agents; Croton; Diterpenes; Diterpenes, Clerodane; Ethanol; Hydrochloric Acid; H

2003
Involvement of eicosanoids in the hypothermic response to lipopolysaccharide during endotoxemia in rats.
    Prostaglandins, leukotrienes, and essential fatty acids, 2004, Volume: 70, Issue:1

    Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Eicosanoids; Endotoxemia; Fever; Hypoth

2004
Inhibition of prostaglandins does not reduce the cardiovascular changes during endotoxemia in rats.
    Prostaglandins, leukotrienes, and essential fatty acids, 2006, Volume: 74, Issue:2

    Topics: Animals; Body Temperature; Dimethyl Sulfoxide; Dinoprostone; Endotoxemia; Heart Rate; Hypothalamus;

2006
Effect of 5-lipoxygenase inhibitor against lipopolysaccharide-induced hypothermia in mice.
    Indian journal of experimental biology, 2005, Volume: 43, Issue:12

    Topics: Animals; Colon; Dinoprostone; Female; Hydroxyurea; Hypothalamus; Hypothermia; Hypothermia, Induced;

2005
Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:19

    Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Hypothermia; Indomethacin; Injections

1982
Effect of acute administration of fish oil (omega-3 marine triglyceride) on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Aspirin; Disease Models, Animal; Ethanol; Female; Fish Oils; Gastric Aci

1995
Hypothermia to endotoxin involves reduced thermogenesis, macrophage-dependent mechanisms, and prostaglandins.
    The American journal of physiology, 1994, Volume: 266, Issue:1 Pt 2

    Topics: Animals; Body Temperature; Body Temperature Regulation; Colon; Dose-Response Relationship, Drug; End

1994
Physiological and behavioural effects of the endogenous cannabinoid, arachidonylethanolamide (anandamide), in the rat.
    British journal of pharmacology, 1996, Volume: 119, Issue:1

    Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Be

1996
Effect of mild hypothermia on the vascular actions of phenylephrine in rat aortic rings.
    British journal of anaesthesia, 1999, Volume: 82, Issue:6

    Topics: Animals; Aorta; Cyclooxygenase Inhibitors; Endothelium, Vascular; Hypothermia; Indomethacin; Nitric

1999
Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice.
    Journal of ethnopharmacology, 1999, Nov-01, Volume: 67, Issue:2

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Gastric

1999
Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress.
    Journal of physiology, Paris, 1999, Volume: 93, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Atropine; Cyclooxygenase Inhibi

1999
Biphasic hypothermia in mice infected with a parasitic nematode, Trichinella spiralis.
    Experimental animals, 2002, Volume: 51, Issue:2

    Topics: Animals; Blood Glucose; Body Temperature; Cyclooxygenase Inhibitors; Hypothermia; Indomethacin; Male

2002
The antipyretic effect of indomethacin.
    The Journal of physiology, 1975, Volume: 248, Issue:3

    Topics: Animals; Body Temperature; Brain; Cats; Cerebral Ventricles; Dose-Response Relationship, Drug; Fever

1975
Lethal hypoglycemia and hypothermia induced by administration of low doses of tumor necrosis factor to adrenalectomized rats.
    Metabolism: clinical and experimental, 1990, Volume: 39, Issue:3

    Topics: Adrenal Medulla; Adrenalectomy; Animals; Blood Glucose; Body Temperature Regulation; Dexamethasone;

1990
Studies on the gastroulcerogenic effects of pylorus ligation, hypothermic restraint stress, aspirin, indomethacin and reserpine in morphine dependent rats.
    Alcohol and drug research, 1987, Volume: 7, Issue:5-6

    Topics: Animals; Aspirin; Gastric Acid; Hypothermia; Indomethacin; Ligation; Male; Morphine Dependence; Pylo

1987