indomethacin has been researched along with Hypotension in 78 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome." | 7.88 | Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome. ( Dawman, L; Santhiya, S; Sharma, A; Tiewsoh, K; Varma, TH, 2018) |
| " The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats." | 7.75 | Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009) |
| "Dexamethasone or indomethacin predisposes very low birth weight (VLBW) neonates to spontaneous intestinal perforation (SIP)." | 7.73 | Concurrent use of indomethacin and dexamethasone increases the risk of spontaneous intestinal perforation in very low birth weight neonates. ( Friedlich, P; Paquette, L; Ramanathan, R; Seri, I, 2006) |
| "Two anephric patients with chronic hypotension were treated with indomethacin (150 mg/day)." | 7.66 | Pressor effects of indomethacin in two anephric patients with chronic hypotension. ( Blumberg, AL; Leslie, BR; Terragno, A; Terragno, NA, 1982) |
| "The effect of indomethacin in hemorrhagic hypotension (HH) on total renal blood flow (RBF) and cortical flow distribution was studied in 9 pentobarbital anesthesized dogs." | 7.65 | The effect of indomethacin on renal blood flow distribution during hemorrhagic hypotension in dog. ( Kirkebo, A; Tyssebotn, I, 1977) |
| "Pretreatment with indomethacin (5 mg/kg i." | 5.30 | The effects of treatment with indomethacin on the cerebral vasculature of newborn piglets before and during hemorrhagic hypotension. ( Hayden, JE; Leffler, CW, 1997) |
| "Indomethacin has been shown to reduce cerebral blood flow and cerebral blood flow velocities in newborn infants and animals of various species." | 5.29 | Brain blood flow responses to indomethacin during hemorrhagic hypotension in newborn piglets. ( Contant, CF; Del Toro, J; Goddard-Finegold, J; Louis, PT; Michael, LH; Yamashita, Y, 1994) |
| "Treatment with indomethacin elevated systemic arterial pressure and pulmonary vascular resistance in hypotensive newborn goats." | 5.26 | Use of indomethacin to reverse neonatal hypotension. ( Cassin, S; Leffler, C; Tyler, T, 1976) |
| "Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome." | 3.88 | Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome. ( Dawman, L; Santhiya, S; Sharma, A; Tiewsoh, K; Varma, TH, 2018) |
| " The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats." | 3.75 | Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009) |
| " In 4-wk-old rabbits treated with l-NAME and Indo, the maximum ACh hypotension was reduced by the potassium channel inhibitors apamin and charybdotoxin to -6." | 3.74 | 15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits. ( Aggarwal, NT; Campbell, WB; Gauthier, KM, 2008) |
| "Dexamethasone or indomethacin predisposes very low birth weight (VLBW) neonates to spontaneous intestinal perforation (SIP)." | 3.73 | Concurrent use of indomethacin and dexamethasone increases the risk of spontaneous intestinal perforation in very low birth weight neonates. ( Friedlich, P; Paquette, L; Ramanathan, R; Seri, I, 2006) |
| " In control ICR mice, intravenous injections of 2-AG or its isomer 1-AG elicit dose-dependent hypotension and moderate tachycardia that are unaffected by the CB1 receptor antagonist SR141716A." | 3.70 | Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized mice. ( Bonner, TI; Goparaju, SK; Járai, Z; Kunos, G; Razdan, RK; Sugiura, T; Wagner, JA; Wang, L; Zimmer, A; Zimmer, AM, 2000) |
| " Radiomicrospheres were used to determine regional cerebral blood flow (rCBF) in piglets pretreated with the opioid receptor antagonist, naloxone, or its vehicle, saline, during normotension, hypotension, and after the administration of indomethacin, a cyclooxygenase inhibitor, during hypotension." | 3.68 | Opioids and the prostanoid system in the control of cerebral blood flow in hypotensive piglets. ( Armstead, WM; Busija, DW; Leffler, CW; Mirro, R, 1991) |
| " Treatment with the putative vascular (V1) receptor antagonist [1-(beta-mercapto-beta, beta-cyclopentamethylene propionic acid-2-(O-methyl)tyrosine]arginine vasopressin (MEAVP) had no effect on regional cerebral blood flow, calculated cerebral vascular resistance, or cerebral metabolic rate either before or during hemorrhagic hypotension." | 3.68 | Vasopressin and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs. ( Armstead, WM; Busija, DW; Leffler, CW; Mirro, R, 1990) |
| " Indomethacin treatment (5 mg/kg ia) of piglets following hemorrhage caused a significant decrease in blood flow to all brain regions within 20 min." | 3.67 | Adrenergic and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs. ( Armstead, WM; Beasley, DG; Busija, DW; Leffler, CW; Mirro, R, 1988) |
| " The effect of hemorrhage on net (arterial-to-venous) cerebral prostacyclin production and the effects of indomethacin on cerebral hemodynamic response to hemorrhage and on the cerebral oxygen utilization following hemorrhage were determined in chronically instrumented, unanesthetized newborn pigs." | 3.67 | Maintenance of cerebral circulation during hemorrhagic hypotension in newborn pigs: role of prostanoids. ( Beasley, DG; Busija, DW; Fletcher, AM; Leffler, CW, 1986) |
| "Two anephric patients with chronic hypotension were treated with indomethacin (150 mg/day)." | 3.66 | Pressor effects of indomethacin in two anephric patients with chronic hypotension. ( Blumberg, AL; Leslie, BR; Terragno, A; Terragno, NA, 1982) |
| "The effect of indomethacin in hemorrhagic hypotension (HH) on total renal blood flow (RBF) and cortical flow distribution was studied in 9 pentobarbital anesthesized dogs." | 3.65 | The effect of indomethacin on renal blood flow distribution during hemorrhagic hypotension in dog. ( Kirkebo, A; Tyssebotn, I, 1977) |
| "When trandolapril treatments (placebo or with indomethacin) were compared to treatments without trandolapril (placebo or indomethacin), trandolapril lowered clinic SBP by 5." | 2.68 | Indomethacin does not attenuate the hypotensive effect of trandolapril. ( Lyons, D; MacDonald, TM; Petrie, JC; Pritchard, G; Webster, J, 1996) |
| "Indomethacin treatment, by itself, did not alter plasma renin activity." | 1.31 | Baroreceptor and prostanoid control of fetal renal cortical blood flow and plasma renin activity. ( Lakhdir, FR; Tong, H; Wood, CE, 2001) |
| "Pretreatment with indomethacin (5 mg/kg i." | 1.30 | The effects of treatment with indomethacin on the cerebral vasculature of newborn piglets before and during hemorrhagic hypotension. ( Hayden, JE; Leffler, CW, 1997) |
| "Indomethacin has been shown to reduce cerebral blood flow and cerebral blood flow velocities in newborn infants and animals of various species." | 1.29 | Brain blood flow responses to indomethacin during hemorrhagic hypotension in newborn piglets. ( Contant, CF; Del Toro, J; Goddard-Finegold, J; Louis, PT; Michael, LH; Yamashita, Y, 1994) |
| "Hypotension was presumably caused by two factors: an early decrease in systemic vascular resistance and the large reduction in cardiac output due to reduced ventricular filling." | 1.29 | Haemodynamic and haematologic effects of Acanthaster planci venom in dogs. ( Hirayama, K; Matsuzaki, T; Noguchi, K; Ojiri, Y; Sakanashi, M; Shiroma, N, 1994) |
| "Pretreatment with indomethacin inhibited the second responses to PAF without affecting the first responses." | 1.29 | Involvement of nitric oxide and eicosanoids in platelet-activating factor-induced haemodynamic and haematological effects in dogs. ( Matsuzaki, T; Noguchi, K; Ojiri, Y; Sakanashi, M; Shiroma, N, 1996) |
| "Pretreatment with bradykinin (BK) antagonist." | 1.29 | Role of synergistic action of PAF and kinin in bacterial endotoxin-induced hypotension in rats. ( Ishida, H; Oh-Ishi, S; Ueno, A, 1996) |
| "Severe necrotizing pancreatitis is accompanied by release of hemorrhagic ascites fluid (HAF), which is thought to be related to the occurrence and frequency of cardiocirculatory and pulmonary failure as a consequence of acute pancreatitis." | 1.28 | Hemodynamic effects following intraperitoneal infusion of pancreatic ascites fluid. ( Kerner, T; Lehnert, P; Schweiberer, L; Vierl, M; Vollmar, B; Waldner, H, 1992) |
| "3 Indomethacin pretreatment prevented the transient decrease in pulmonary removal of [3H]-PGE1 in response to endotoxin, prevented the haemodynamic effects and inhibited prostaglandin synthesis." | 1.27 | Effect of nafazatrom and indomethacin on pulmonary removal of prostaglandin E1 after endotoxin in rabbits. ( Gillis, CN; Havill, AM; Moalli, R, 1987) |
| "Hypotension was induced by hemorrhage (30 ml/kg) which reduced mean arterial pressure from 60 to 34 mm Hg." | 1.27 | Effect of therapeutic dose of indomethacin on the cerebral circulation of newborn pigs. ( Beasley, DG; Busija, DW; Leffler, CW, 1987) |
| "Indomethacin (5 mg/kg) was used to pretreat the support dogs and LLL donors of group II (n = 9); support dogs of group III (n = 5); and LLL donors of group IV (n = 4)." | 1.26 | Prostaglandin mediation of unstable hemodynamics during lung perfusion. ( Grindlinger, GA; Hechtman, HB; Levine, LL; Shepro, D; Utsunomiya, T; Vegas, A, 1982) |
| "Treatment with indomethacin elevated systemic arterial pressure and pulmonary vascular resistance in hypotensive newborn goats." | 1.26 | Use of indomethacin to reverse neonatal hypotension. ( Cassin, S; Leffler, C; Tyler, T, 1976) |
| "Systemic hypotension was not observed and the blood pressure in the indomethacintreated cats 1, 2 and 4 h after endotoxin was 30 mmHg higher than in those cats administered endotoxin alone." | 1.25 | The effect of indomethacin on the cardiovascular and metabolic responses to E. coli endotoxin in the cat. ( Parratt, JR; Sturgess, RM, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (51.28) | 18.7374 |
| 1990's | 18 (23.08) | 18.2507 |
| 2000's | 12 (15.38) | 29.6817 |
| 2010's | 8 (10.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varma, TH | 1 |
| Sharma, A | 1 |
| Santhiya, S | 1 |
| Dawman, L | 1 |
| Tiewsoh, K | 1 |
| Shinomiya, S | 1 |
| Shibamoto, T | 1 |
| Kurata, Y | 1 |
| Kuda, Y | 1 |
| Zhang, W | 1 |
| Tanida, M | 1 |
| Toga, H | 1 |
| Dutta, S | 1 |
| Singh, B | 1 |
| Chessell, L | 1 |
| Wilson, J | 1 |
| Janes, M | 1 |
| McDonald, K | 1 |
| Shahid, S | 1 |
| Gardner, VA | 1 |
| Hjartarson, A | 1 |
| Purcha, M | 1 |
| Watson, J | 1 |
| de Boer, C | 1 |
| Gaal, B | 1 |
| Fusch, C | 1 |
| Madlala, HP | 1 |
| Metzinger, T | 1 |
| van Heerden, FR | 1 |
| Musabayane, CT | 1 |
| Mubagwa, K | 1 |
| Dessy, C | 1 |
| Liebowitz, M | 1 |
| Koo, J | 1 |
| Wickremasinghe, A | 1 |
| Allen, IE | 1 |
| Clyman, RI | 1 |
| Tunctan, B | 1 |
| Yaghini, FA | 1 |
| Estes, A | 1 |
| Malik, KU | 1 |
| Naseri, MK | 1 |
| Arabian, M | 1 |
| Badavi, M | 1 |
| Ahangarpour, A | 1 |
| Subramani, J | 1 |
| Kathirvel, K | 1 |
| Leo, MD | 1 |
| Kuntamallappanavar, G | 1 |
| Uttam Singh, T | 1 |
| Mishra, SK | 1 |
| Yamada, Y | 1 |
| Iwasaki, M | 1 |
| Usui, H | 1 |
| Ohinata, K | 1 |
| Marczak, ED | 1 |
| Lipkowski, AW | 1 |
| Yoshikawa, M | 1 |
| Laukeviciene, A | 1 |
| Ugincius, P | 1 |
| Korotkich, I | 1 |
| Lazauskas, R | 1 |
| Kevelaitis, E | 1 |
| Chaisakul, J | 1 |
| Isbister, GK | 1 |
| Konstantakopoulos, N | 1 |
| Tare, M | 1 |
| Parkington, HC | 1 |
| Hodgson, WC | 1 |
| Okajima, K | 2 |
| Isobe, H | 2 |
| Uchiba, M | 2 |
| Harada, N | 2 |
| Domoki, F | 1 |
| Nagy, K | 1 |
| Temesvári, P | 1 |
| Bari, F | 1 |
| Paquette, L | 1 |
| Friedlich, P | 1 |
| Ramanathan, R | 1 |
| Seri, I | 1 |
| Sarkar, S | 1 |
| Dechert, R | 1 |
| Schumacher, RE | 1 |
| Donn, SM | 1 |
| Aggarwal, NT | 1 |
| Gauthier, KM | 1 |
| Campbell, WB | 1 |
| Todd, MH | 1 |
| Cragg, DB | 1 |
| Forrest, JB | 1 |
| Ali, M | 1 |
| McDonald, JW | 1 |
| Orlov, LL | 1 |
| Chogovadze, VA | 1 |
| Lukacsko, P | 1 |
| Montgomery, SB | 1 |
| Jose, PA | 1 |
| Slotkoff, LM | 1 |
| Lilienfield, LS | 1 |
| Eisner, GM | 1 |
| Wong, PC | 1 |
| Zimmerman, BG | 1 |
| Friedman, P | 1 |
| Clarke, DE | 1 |
| Wagner, LB | 1 |
| Wagner, LA | 1 |
| Grindlinger, GA | 1 |
| Utsunomiya, T | 1 |
| Vegas, A | 1 |
| Levine, LL | 1 |
| Shepro, D | 1 |
| Hechtman, HB | 1 |
| Leslie, BR | 1 |
| Terragno, A | 1 |
| Terragno, NA | 1 |
| Blumberg, AL | 1 |
| Wechsung, E | 2 |
| Houvenaghel, A | 2 |
| Koyama, K | 1 |
| Kaneko, I | 1 |
| Mori, K | 1 |
| Louis, PT | 1 |
| Yamashita, Y | 1 |
| Del Toro, J | 1 |
| Michael, LH | 1 |
| Contant, CF | 1 |
| Goddard-Finegold, J | 1 |
| Xavier-Neto, J | 1 |
| Krieger, EM | 1 |
| Shiroma, N | 2 |
| Noguchi, K | 2 |
| Matsuzaki, T | 2 |
| Ojiri, Y | 2 |
| Hirayama, K | 1 |
| Sakanashi, M | 2 |
| Inazu, M | 1 |
| Tujitani, M | 1 |
| Sugimoto, K | 1 |
| Kawamura, M | 1 |
| Katori, M | 1 |
| Shindo, M | 1 |
| Ohwada, T | 1 |
| Christy, IJ | 1 |
| Woods, RL | 1 |
| Anderson, WP | 1 |
| Hayden, JE | 1 |
| Leffler, CW | 7 |
| Pritchard, G | 1 |
| Lyons, D | 1 |
| Webster, J | 1 |
| Petrie, JC | 1 |
| MacDonald, TM | 1 |
| Oh-Ishi, S | 1 |
| Ishida, H | 1 |
| Ueno, A | 1 |
| Lewis, K | 1 |
| Cadieux, A | 1 |
| Rae, GA | 1 |
| Gratton, JP | 1 |
| D'Orléans-Juste, P | 1 |
| Tong, H | 2 |
| Wood, CE | 2 |
| Járai, Z | 1 |
| Wagner, JA | 1 |
| Goparaju, SK | 1 |
| Wang, L | 1 |
| Razdan, RK | 1 |
| Sugiura, T | 1 |
| Zimmer, AM | 1 |
| Bonner, TI | 1 |
| Zimmer, A | 1 |
| Kunos, G | 1 |
| Pires, SL | 1 |
| de Assis, TS | 1 |
| de Almeida, RN | 1 |
| Filho, JM | 1 |
| Julien, C | 1 |
| de Medeiros, IA | 1 |
| Lakhdir, FR | 1 |
| Menzel, K | 1 |
| Schambach, K | 1 |
| Töpke, B | 1 |
| Oates, JA | 1 |
| Whorton, AR | 1 |
| Gerkens, JF | 1 |
| Branch, RA | 1 |
| Hollifield, JW | 1 |
| Frölich, JC | 1 |
| Stahl, R | 1 |
| Dienemann, H | 1 |
| Kneissler, U | 1 |
| Christ, H | 1 |
| Helmchen, U | 1 |
| Henrich, WL | 1 |
| Schrier, RW | 1 |
| Berl, T | 1 |
| Haeusler, G | 1 |
| Gerold, M | 1 |
| Cedro, A | 1 |
| Herbaczyńska-Cedro, K | 1 |
| Herman, AG | 2 |
| Vane, JR | 2 |
| Data, JL | 1 |
| Chang, LC | 1 |
| Nies, AS | 1 |
| Tyssebotn, I | 1 |
| Kirkebo, A | 1 |
| Ferris, TF | 1 |
| Venuto, RC | 1 |
| Bay, WH | 1 |
| Tyler, T | 1 |
| Leffler, C | 1 |
| Cassin, S | 1 |
| Johnston, PA | 1 |
| Selkurt, EE | 1 |
| Stonier, C | 1 |
| Bennett, J | 1 |
| Messenger, EA | 1 |
| Aber, GM | 1 |
| Vollmar, B | 1 |
| Waldner, H | 1 |
| Vierl, M | 1 |
| Kerner, T | 1 |
| Lehnert, P | 1 |
| Schweiberer, L | 1 |
| Armstead, WM | 3 |
| Mirro, R | 3 |
| Busija, DW | 6 |
| Pontieri, V | 1 |
| Lopes, OU | 1 |
| Ferreira, SH | 1 |
| Skoog, P | 1 |
| Månsson, J | 1 |
| Thorén, P | 1 |
| Laurindo, FR | 1 |
| Goldstein, RE | 1 |
| Davenport, NJ | 1 |
| Ezra, D | 1 |
| Feuerstein, GZ | 1 |
| Hoeldtke, RD | 1 |
| O'Dorisio, TM | 1 |
| Boden, G | 1 |
| Beasley, DG | 3 |
| Sosman, JA | 1 |
| Kohler, PC | 1 |
| Hank, JA | 1 |
| Moore, KH | 1 |
| Bechhofer, R | 1 |
| Storer, B | 1 |
| Sondel, PM | 1 |
| Gillis, CN | 1 |
| Havill, AM | 1 |
| Moalli, R | 1 |
| Fletcher, AM | 1 |
| Lundberg, C | 1 |
| Gardinali, M | 1 |
| Hugli, TE | 1 |
| Olsen, UB | 1 |
| Bille-Hansen, V | 1 |
| Damas, J | 1 |
| Lecomte, J | 1 |
| Salmon, J | 1 |
| Vatner, SF | 1 |
| Parratt, JR | 1 |
| Sturgess, RM | 1 |
| Silen, W | 1 |
| Collier, JG | 1 |
| Vargaftig, BB | 1 |
| Vargaftig, B | 1 |
2 reviews available for indomethacin and Hypotension
| Article | Year |
|---|---|
Guidelines for feeding very low birth weight infants.
Topics: Breast Feeding; Canada; Enema; Enteral Nutrition; Fetal Blood; Food, Fortified; Gastroesophageal Ref | 2015 |
[The patent ductus arteriosus from a perinatological viewpoint].
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Fetus; Gastrointestinal Hemorrhage; Growth; Hu | 1978 |
4 trials available for indomethacin and Hypotension
| Article | Year |
|---|---|
[The effect of indomethacin suppository in preventing mesenteric traction syndrome].
Topics: Adult; Anesthesia, Epidural; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Female; H | 1995 |
Indomethacin does not attenuate the hypotensive effect of trandolapril.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Bloo | 1996 |
Treatment of autonomic neuropathy with a somatostatin analogue SMS-201-995.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Caffeine; Chronic Disease; Female; H | 1986 |
Repetitive weekly cycles of interleukin-2. II. Clinical and immunologic effects of dose, schedule, and addition of indomethacin.
Topics: Adult; Aged; Cytotoxicity, Immunologic; Drug Administration Schedule; Female; Fever; Humans; Hypoten | 1988 |
72 other studies available for indomethacin and Hypotension
| Article | Year |
|---|---|
Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome.
Topics: Alkalosis; Bartter Syndrome; Child, Preschool; Cyclooxygenase Inhibitors; Diuretics; Female; Furosem | 2018 |
Nitric oxide and β(2)-adrenoceptor activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice.
Topics: Adrenergic beta-Antagonists; Anaphylaxis; Animals; Atenolol; Bronchoconstriction; Cyclooxygenase Inh | 2013 |
Vascular Endothelium-Dependent and Independent Actions of Oleanolic Acid and Its Synthetic Oleanane Derivatives as Possible Mechanisms for Hypotensive Effects.
Topics: Animals; Antihypertensive Agents; Endothelium, Vascular; Hypertension; Hypotension; Indomethacin; Ma | 2016 |
Effects of Prophylactic Indomethacin on Vasopressor-Dependent Hypotension in Extremely Preterm Infants.
Topics: Cardiovascular Agents; Cohort Studies; Dopamine; Ductus Arteriosus, Patent; Echocardiography; Female | 2017 |
Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production.
Topics: Amitrole; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Blotting, Western; Cytoc | 2008 |
Vasorelaxant and hypotensive effects of Allium cepa peel hydroalcoholic extract in rat.
Topics: Alcohols; Animals; Dose-Response Relationship, Drug; Hypotension; Indomethacin; Male; Methylene Blue | 2008 |
Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis.
Topics: Acetylcholine; Animals; Aorta; Atorvastatin; Biological Factors; Blood Cell Count; Blood Pressure; C | 2009 |
Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK(1) receptor.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Bradykinin B1 Receptor Antagonists; Br | 2010 |
Anaphylaxis of small arteries: putative role of nitric oxide and prostanoids.
Topics: Analysis of Variance; Anaphylaxis; Animals; Coronary Vessels; Endothelium, Vascular; Freund's Adjuva | 2010 |
In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring "sudden collapse".
Topics: Animals; Australasia; Cardiovascular Agents; Cardiovascular System; Elapid Venoms; Hypotension; In V | 2012 |
Role of sensory neuron in reduction of endotoxin-induced hypotension in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; C | 2005 |
Selective inhibitors differentially affect cyclooxygenase-dependent pial arteriolar responses in newborn pigs.
Topics: Acetaminophen; Animals; Animals, Newborn; Arterioles; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge | 2005 |
Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats.
Topics: Animals; Antithrombins; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Calciton | 2006 |
Concurrent use of indomethacin and dexamethasone increases the risk of spontaneous intestinal perforation in very low birth weight neonates.
Topics: Case-Control Studies; Dexamethasone; Ductus Arteriosus, Patent; Female; Humans; Hypotension; Indomet | 2006 |
Is refractory hypotension in preterm infants a manifestation of early ductal shunting?
Topics: Anti-Inflammatory Agents; Birth Weight; Drug Administration Schedule; Ductus Arteriosus, Patent; Fem | 2007 |
15-Lipoxygenase metabolites contribute to age-related reduction in acetylcholine-induced hypotension in rabbits.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Acetylcholine; Age Factors; Aging; Ani | 2008 |
The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Anesthesia, General; Animals; Aspirin; Hypotension; Indomethacin; Lung | 1983 |
[Indomethacin in the hypotonic type of neurocirculatory dystonia].
Topics: Adult; Catecholamines; Echocardiography; Exercise Test; Female; Humans; Hypotension; Indomethacin; M | 1984 |
Paradoxical bradycardia following the administration of sodium nitroprusside in the rat is abolished by indomethacin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Bradycardia; Ferricyanides; Heart Rate | 1982 |
The regulation of intrarenal blood flow in the dog during ischemia.
Topics: Animals; Aorta; Blood Pressure; Constriction; Dogs; Female; Hemodynamics; Hemorrhage; Hypotension; I | 1980 |
Release of PGE and PGI2 in the pump-perfused dog kidney and associated hypotension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Captopril; Dogs; Epoprostenol; Female; Hypote | 1981 |
Studies on the mechanism of captopril induced hypotension in rats.
Topics: Angiotensin I; Angiotensins; Animals; Blood Pressure; Bradykinin; Captopril; Dose-Response Relations | 1981 |
Prostaglandin mediation of unstable hemodynamics during lung perfusion.
Topics: Animals; Cardiac Output, Low; Dogs; Hemodynamics; Hypotension; Indomethacin; Lung; Positive-Pressure | 1982 |
Pressor effects of indomethacin in two anephric patients with chronic hypotension.
Topics: Adult; Female; Heart Rate; Humans; Hypotension; Indomethacin; Male; Middle Aged; Nephrectomy; Placeb | 1982 |
Effect of arachidonic acid on oviductal pressure in the domestic hen.
Topics: Animals; Aorta; Arachidonic Acids; Chickens; Female; Hypotension; Indomethacin; Injections, Intra-Ar | 1981 |
Brain blood flow responses to indomethacin during hemorrhagic hypotension in newborn piglets.
Topics: Animals; Animals, Newborn; Blood Pressure; Brain; Dose-Response Relationship, Drug; Female; Hemorrha | 1994 |
Viscoelastic behavior of "in situ" aortic wall during hemorrhagic hypotension.
Topics: Animals; Aorta; Arginine; Blood Pressure; Elasticity; Gases; Hemorrhage; Hydrogen-Ion Concentration; | 1995 |
Haemodynamic and haematologic effects of Acanthaster planci venom in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Cells; Blood Pressure; Cardiac Output; Cyclooxygenase I | 1994 |
Effect of LP-805, a releaser of endothelium-derived nitric oxide, on systemic vasodilatation in vivo.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vas | 1993 |
Transmigration routes and a delayed systemic hypotension in rats after intraperitoneal injection of endotoxin from Escherichia coli.
Topics: Animals; Body Temperature; Dinoprostone; Endotoxins; Escherichia coli; Exudates and Transudates; Hem | 1993 |
Mediators of the hypotensive response to increased renal perfusion in rabbits.
Topics: Animals; Azepines; Blood Pressure; Diuresis; Enalaprilat; Hemodynamics; Hypotension; Indomethacin; N | 1993 |
Involvement of nitric oxide and eicosanoids in platelet-activating factor-induced haemodynamic and haematological effects in dogs.
Topics: Animals; Benzoquinones; Biphenyl Compounds; Cell Count; Cyclooxygenase Inhibitors; Dogs; Dose-Respon | 1996 |
The effects of treatment with indomethacin on the cerebral vasculature of newborn piglets before and during hemorrhagic hypotension.
Topics: Animals; Animals, Newborn; Arterioles; Blood Gas Analysis; Blood Pressure; Hemorrhage; Hydrogen-Ion | 1997 |
Role of synergistic action of PAF and kinin in bacterial endotoxin-induced hypotension in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Bradykin | 1996 |
Nitric oxide limits the eicosanoid-dependent bronchoconstriction and hypotension induced by endothelin-1 in the guinea-pig.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Resistance; Animals; Anti | 1999 |
Indomethacin attenuates the cerebral blood flow response to hypotension in late-gestation fetal sheep.
Topics: Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Blood Pressure; Cerebrovascular Circulat | 1999 |
Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized mice.
Topics: Anesthesia; Animals; Arachidonic Acids; Blood Pressure; Camphanes; Cardiovascular Agents; Cardiovasc | 2000 |
Endothelium-derived nitric oxide is involved in the hypotensive and vasorelaxant responses induced by the aqueous fraction of the ethanolic extract of the leaves of Albizia inopinata (Harms) G. P. Lewis in rats.
Topics: Animals; Aorta; Atropine; Blood Pressure; Endothelium, Vascular; Ethanol; Heart; Heart Atria; Heart | 2000 |
Baroreceptor and prostanoid control of fetal renal cortical blood flow and plasma renin activity.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Den | 2001 |
The participation of prostaglandins in the control of renin release.
Topics: Aldosterone; Animals; Dogs; Epoprostenol; Hypotension; Indomethacin; Kidney; Prostaglandins; Rabbits | 1979 |
Indomethacin induced hypotension in sodium and volume depleted rats.
Topics: Animals; Blood Pressure; Hyponatremia; Hypotension; Indomethacin; Male; Rats; Renin | 1979 |
Mechanisms of renin secretion during hemorrhage in the dog.
Topics: Animals; Dogs; Hemodynamics; Hemorrhage; Hypotension; Indomethacin; Kidney; Natriuresis; Perfusion; | 1979 |
Increased levels of prostaglandin-like material in the canine blood during arterial hypotension produced by hydralazine, dihydralazine and minoxidil.
Topics: Angiotensin II; Animals; Blood Pressure; Dihydralazine; Dogs; Female; Guinea Pigs; Hydralazine; Hypo | 1979 |
Increased blood level of prostaglandin-like substances during cardiopulmonary bypass in the dog.
Topics: Animals; Biological Assay; Blood Pressure; Cardiopulmonary Bypass; Dogs; Female; Hypotension; Indome | 1978 |
Release of renal prostaglandins during endotoxin-induced hypotension.
Topics: Animals; Blood Pressure; Dogs; Endotoxins; Escherichia coli; Female; Hypotension; Indomethacin; Kidn | 1976 |
Alteration of canine renal vascular response to hemorrhage by inhibitors of prostaglandin synthesis.
Topics: Animals; Aspirin; Blood Pressure; Cardiac Output; Cyclooxygenase Inhibitors; Depression, Chemical; D | 1976 |
The effect of indomethacin on renal blood flow distribution during hemorrhagic hypotension in dog.
Topics: Animals; Dogs; Female; Hemorrhage; Hydrogen; Hypotension; Indomethacin; Kidney; Kidney Cortex; Male; | 1977 |
Studies of the uterine circulation in the pregnant rabbit.
Topics: Animals; Blood Pressure; Female; Homeostasis; Hypertension; Hypotension; Indomethacin; Nephrectomy; | 1976 |
Use of indomethacin to reverse neonatal hypotension.
Topics: Animals; Animals, Newborn; Capillary Resistance; Goats; Hypotension; Indomethacin; Pulmonary Circula | 1976 |
Effect of hemorrhagic shock on renal release of prostaglandin E.
Topics: Aminohippuric Acids; Animals; Blood Pressure; Calcium; Dogs; Hypotension; Indomethacin; Inulin; Kidn | 1976 |
Oestradiol-induced hypotension in spontaneously hypertensive rats: putative role for intracellular cations, sodium-potassium flux and prostanoids.
Topics: Animals; Blood Pressure; Body Weight; Erythrocytes; Estradiol; Female; Hematocrit; Hypotension; Indo | 1992 |
Hemodynamic effects following intraperitoneal infusion of pancreatic ascites fluid.
Topics: Acute Disease; Animals; Ascitic Fluid; Disease Models, Animal; Extravascular Lung Water; Hemodynamic | 1992 |
Opioids and the prostanoid system in the control of cerebral blood flow in hypotensive piglets.
Topics: Animals; Arteries; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Cardiac Output; Cerebrovascu | 1991 |
Vasopressin and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs.
Topics: Animals; Animals, Newborn; Arginine Vasopressin; Biomechanical Phenomena; Blood Pressure; Cardiac Ou | 1990 |
Hypotensive effect of captopril. Role of bradykinin and prostaglandinlike substances.
Topics: Animals; Blood Pressure; Bradykinin; Captopril; Dogs; Drug Synergism; Female; Hypotension; Ileum; In | 1990 |
Changes in renal sympathetic outflow during hypotensive haemorrhage in rats.
Topics: Afferent Pathways; Animals; Aprotinin; Blood Pressure; Heart Rate; Hemorrhage; Hypotension; Indometh | 1985 |
Mechanisms of hypotension produced by platelet-activating factor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Female; Hypotension; In | 1989 |
Adrenergic and prostanoid mechanisms in control of cerebral blood flow in hypotensive newborn pigs.
Topics: Animals; Animals, Newborn; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Hemor | 1988 |
Effect of nafazatrom and indomethacin on pulmonary removal of prostaglandin E1 after endotoxin in rabbits.
Topics: Alprostadil; Animals; Endotoxins; Escherichia coli; Hemodynamics; Hypertension, Pulmonary; Hypotensi | 1987 |
Cardiovascular effects of leukotriene C4 and D4 in the anesthetized and conscious domestic hen.
Topics: Anesthesia; Animals; Blood Pressure; Cardiovascular System; Chickens; Consciousness; Dose-Response R | 1986 |
Maintenance of cerebral circulation during hemorrhagic hypotension in newborn pigs: role of prostanoids.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Blood Gas Analysis; Brain; Cerebrovascular | 1986 |
Prostanoids and pial arteriolar diameter in hypotensive newborn pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Arterioles; Cerebral Arteries; Cerebrovascu | 1987 |
Complement activation and membrane lipids in lung vascular injury.
Topics: Animals; Blood Vessels; Complement Activation; Complement C5; Complement C5a; Hemodynamics; Hypotens | 1987 |
Exaggerated hypotension by N-formylmethionylleucyl-phenylalanine in indomethacin pretreated rats. Role of toxic oxygen.
Topics: Animals; Ascorbic Acid; Blood Pressure; Dimethyl Sulfoxide; Endotoxins; Female; Glucagon; Hypotensio | 1986 |
Effect of therapeutic dose of indomethacin on the cerebral circulation of newborn pigs.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Cardiac Output; Cerebrovascular Circulation; Hydrogen | 1987 |
[Prostaglandins are not responsible for anaphylactic hypotension in the rat].
Topics: Anaphylaxis; Animals; Histamine H1 Antagonists; Hypotension; Indomethacin; Injections, Intravenous; | 1974 |
Effects of hemorrhage on regional blood flow distribution in dogs and primates.
Topics: Animals; Atropine; Blood Circulation; Blood Flow Velocity; Blood Pressure; Cardiac Output; Coronary | 1974 |
The effect of indomethacin on the cardiovascular and metabolic responses to E. coli endotoxin in the cat.
Topics: Acidosis; Animals; Arteries; Blood; Blood Glucose; Cardiac Output; Cats; Central Venous Pressure; En | 1974 |
The Berry Lecture. Studies of the gastric mucosal barrier--its relevance to clinical gastric disease.
Topics: Animals; Aspirin; Dogs; Epithelium; Female; Gastric Mucins; Gastric Mucosa; Gastritis; Humans; Hydro | 1972 |
Appearance of prostaglandins in the renal venous blood of dogs in response to acute systemic hypotension produced by bleeding or endotoxin.
Topics: Animals; Blood Pressure; Dogs; Endotoxins; Female; Hemorrhage; Hypotension; Indomethacin; Kidney; Ma | 1973 |
[Antagonism of non-narcotic analgesics to the release of plasma kinins by B. jararaca venom and pancreatic kallikrein].
Topics: Aminopyrine; Analgesics; Animals; Antipyrine; Antivenins; Arteries; Aspirin; Blood Pressure; Bradyki | 1967 |
[Effect of non-narcotic analgesics on hypotension due to bradykinin].
Topics: Aminopyrine; Animals; Aspirin; Blood Pressure; Bradykinin; Hypotension; Indomethacin; Phenylbutazone | 1966 |