indomethacin has been researched along with Hypokalemia in 38 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome." | 7.88 | Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome. ( Dawman, L; Santhiya, S; Sharma, A; Tiewsoh, K; Varma, TH, 2018) |
| "This paper details the case of a 26-year-old woman with depletion syndrome and the effectiveness of her treatment with indomethacin." | 7.85 | Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma. ( Kagan, MD; Sangha, G; Schmidt, K, 2017) |
| "During treatment with indomethacin in a patient with Bartter's syndrome, hypokalemia, high plasma renin concentration, hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected." | 7.65 | Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin. ( Amery, A; Clement, J; Michielsen, P; van Damme B, B; Verberckmoes, R, 1976) |
| "Indomethacin was the most effective but can cause gastrointestinal intolerance and decreased eGFR." | 6.80 | Indomethacin, amiloride, or eplerenone for treating hypokalemia in Gitelman syndrome. ( Allard, J; Azizi, M; Baron, S; Bergerot, D; Blanchard, A; Bridoux, F; Caumont-Prim, A; Desport, E; Dubourg, L; Essig, M; Monge, M; Tack, I; Vallet, M; Vargas-Poussou, R, 2015) |
| "Furosemide is one of the most common drug used to treat anasarca in childhood nephrotic syndrome." | 3.88 | Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome. ( Dawman, L; Santhiya, S; Sharma, A; Tiewsoh, K; Varma, TH, 2018) |
| "This paper details the case of a 26-year-old woman with depletion syndrome and the effectiveness of her treatment with indomethacin." | 3.85 | Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma. ( Kagan, MD; Sangha, G; Schmidt, K, 2017) |
| "A four-year-old girl with growth failure and clinical and laboratory evidence of Bartter's syndrome responded to indomethacin treatment with decreased urinary prostaglandin excretion, symptomatic and chemical improvement, and accelerated growth." | 3.67 | Reversal of Bartter's syndrome by renal transplantation in a child with focal, segmental glomerular sclerosis. ( Blethen, SL; Jennette, JC; Lorentz, WB; Van Wyk, JJ, 1985) |
| "During treatment with indomethacin in a patient with Bartter's syndrome, hypokalemia, high plasma renin concentration, hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected." | 3.65 | Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin. ( Amery, A; Clement, J; Michielsen, P; van Damme B, B; Verberckmoes, R, 1976) |
| "Indomethacin was the most effective but can cause gastrointestinal intolerance and decreased eGFR." | 2.80 | Indomethacin, amiloride, or eplerenone for treating hypokalemia in Gitelman syndrome. ( Allard, J; Azizi, M; Baron, S; Bergerot, D; Blanchard, A; Bridoux, F; Caumont-Prim, A; Desport, E; Dubourg, L; Essig, M; Monge, M; Tack, I; Vallet, M; Vargas-Poussou, R, 2015) |
| "For the first time neonatal variant of Bartter syndrome to 14." | 2.42 | [Bartter syndrome and it's neonatal type]. ( Jakutovic, M; Jankauskiene, A, 2003) |
| "Antenatal Bartter syndrome is characterized by severe polyhydramnios in mother leading to premature delivery." | 1.40 | Antenatal Bartter syndrome. ( Afzal, M; Anwar, V; Azam, S; Khan, EA; Khan, WA; Rafiq, S; Yaqoob, A, 2014) |
| "Gitelman's syndrome is a renal tubule disease of recessive autosomal inheritance in which the fundamental alteration is found in the distal tubule, specifically at the level of the Na/Cl cotransporter, is sensitive to thiazides, and coded in chromosome 16q." | 1.40 | [Casual diagnosis of Gitelman's syndrome]. ( Garcia-Esteve, L; Lafarga-Giribets, MA; Martín-Miguel, V; Rodrigo-Claverol, MD, 2014) |
| "Bartter syndrome is a group of rare autosomal-recessive disorders caused by a defect in distal tubule transport of sodium and chloride." | 1.38 | Classic Bartter syndrome: a rare cause of failure to thrive in a child. ( da Silva, JE; Mendes, L; Mendes, P; Vieira, H, 2012) |
| "With early diagnosis and proper treatment, Bartter syndrome has a good prognosis." | 1.35 | Bartter syndrome presenting as poor weight gain and abdominal mass in an infant. ( Gilbert-Barness, E; Heffernan, A; Perlman, S; Steffensen, TS, 2008) |
| "The patients invariably developed chronic renal failure." | 1.31 | Hypokalemic salt-losing tubulopathy with chronic renal failure and sensorineural deafness. ( Henne, T; Jeck, N; Klaus, G; Konrad, M; Leonhardt, A; Mallmann, R; Marg, W; Pasel, K; Reinalter, SC; Seyberth, HW; Vollmer, M, 2001) |
| "The child was shown to have Bartter syndrome." | 1.28 | Transient gall bladder dilatation associated with hypokalaemia in a patient with Bartter syndrome. ( Drachman, R; Drukker, A; Goren, A; Hadas-Halperin, I, 1989) |
| "Treatment with indomethacin also improved the pressor responsiveness to angiotensin II and norepinephrine, but this occurred in association with a decrease in PRA, PAC and urinary excretion of PGE2 and PGF2 alpha." | 1.27 | Hypokalemia and prostaglandin overproduction in Bartter's syndrome. ( Amagasaki, Y; Kato, E; Konishi, K; Nakata, I; Ozawa, Y; Saruta, T; Senba, S, 1984) |
| "Unlike Bartter syndrome, there is no defect in tubular reabsorption of chloride." | 1.27 | Congenital hypokalemia with hypercalciuria in preterm infants: a hyperprostaglandinuric tubular syndrome different from Bartter syndrome. ( Kühl, PG; Mehls, O; Rascher, W; Schärer, K; Schweer, H; Seyberth, HW, 1985) |
| "In the subjects with Bartter's syndrome, however, distal reabsorption was impaired, this defect being apparently independent of PG as it was unaffected by inhibition of PG synthesis." | 1.27 | Relationship of renal prostaglandins to distal transport of sodium chloride in normokalemic and hypokalemic man. ( Favre, H; Favre, L; Paunier, L; Vallotton, MB; Williams, G, 1985) |
| "Treatment with indomethacin for 6 or 7 days did not affect dopamine excretion in either Bartter's syndrome or in a group of normal control subjects." | 1.26 | Free dopamine excretion in disorders with increased prostaglandin synthesis. ( Güllner, HG, 1982) |
| "Two patients, one with Bartter's syndrome and one with severe abuse of diuretics, were investigated before and after indomethacin treatment." | 1.26 | On the pathogenetic role of prostaglandins in Bartter's syndrome. ( Christensen, P; Hesse, B; Nielsen, I, 1979) |
| "A 63-year-old man had asymptomatic Bartter's syndrome, discovered during evaluation for hypokalemia." | 1.26 | Asymptomatic Bartter's syndrome. ( Barbour, GL; Day, JO, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (63.16) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 5 (13.16) | 29.6817 |
| 2010's | 6 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varma, TH | 1 |
| Sharma, A | 1 |
| Santhiya, S | 1 |
| Dawman, L | 1 |
| Tiewsoh, K | 1 |
| Afzal, M | 1 |
| Khan, EA | 1 |
| Khan, WA | 1 |
| Anwar, V | 1 |
| Yaqoob, A | 1 |
| Rafiq, S | 1 |
| Azam, S | 1 |
| Blanchard, A | 1 |
| Vargas-Poussou, R | 1 |
| Vallet, M | 1 |
| Caumont-Prim, A | 1 |
| Allard, J | 1 |
| Desport, E | 1 |
| Dubourg, L | 1 |
| Monge, M | 1 |
| Bergerot, D | 1 |
| Baron, S | 1 |
| Essig, M | 1 |
| Bridoux, F | 1 |
| Tack, I | 1 |
| Azizi, M | 1 |
| Martín-Miguel, V | 1 |
| Lafarga-Giribets, MA | 1 |
| Garcia-Esteve, L | 1 |
| Rodrigo-Claverol, MD | 1 |
| Kagan, MD | 1 |
| Schmidt, K | 1 |
| Sangha, G | 1 |
| Onem, Y | 1 |
| Kucukardali, Y | 1 |
| Sahan, B | 1 |
| Atasoyu, EM | 1 |
| Ipcioğlu, O | 1 |
| Terekeci, H | 1 |
| Solmazgul, E | 1 |
| Top, C | 1 |
| Oktenli, C | 1 |
| Heffernan, A | 1 |
| Steffensen, TS | 1 |
| Gilbert-Barness, E | 1 |
| Perlman, S | 1 |
| Vieira, H | 1 |
| Mendes, L | 1 |
| Mendes, P | 1 |
| da Silva, JE | 1 |
| Jankauskiene, A | 1 |
| Jakutovic, M | 1 |
| Senba, S | 1 |
| Konishi, K | 1 |
| Saruta, T | 1 |
| Ozawa, Y | 1 |
| Kato, E | 1 |
| Amagasaki, Y | 1 |
| Nakata, I | 1 |
| Peterson, LN | 1 |
| Blümel, P | 1 |
| Fink, M | 1 |
| Stögmann, W | 1 |
| Rutecki, GW | 1 |
| Cox, JW | 1 |
| Robertson, GW | 1 |
| Francisco, LL | 1 |
| Ferris, TF | 2 |
| Güllner, HG | 1 |
| Chan, JC | 1 |
| Dunn, MJ | 1 |
| Rodriguez, JA | 1 |
| Delea, CS | 1 |
| Bartter, FC | 2 |
| Siragy, H | 1 |
| de Jong, PE | 1 |
| Donker, AJ | 1 |
| van der Wall, E | 1 |
| Erkelens, DW | 1 |
| van der Hem, GK | 1 |
| Doorenbos, H | 1 |
| Berl, T | 1 |
| Aisenbrey, GA | 1 |
| Linas, SL | 1 |
| Agnoli, GC | 1 |
| Borgatti, R | 1 |
| Cacciari, M | 1 |
| Garutti, C | 1 |
| Ikonomu, E | 1 |
| Lenzi, P | 1 |
| Marinelli, M | 1 |
| Bień, B | 1 |
| Lamnari, AM | 1 |
| Górska, M | 1 |
| Jeck, N | 1 |
| Reinalter, SC | 2 |
| Henne, T | 1 |
| Marg, W | 1 |
| Mallmann, R | 1 |
| Pasel, K | 1 |
| Vollmer, M | 1 |
| Klaus, G | 2 |
| Leonhardt, A | 1 |
| Seyberth, HW | 3 |
| Konrad, M | 2 |
| Gröne, HJ | 1 |
| Jaffe, BM | 1 |
| Kopen, DF | 1 |
| DeSchryver-Kecskemeti, K | 1 |
| Gingerich, RL | 1 |
| Greider, M | 1 |
| Nielsen, I | 1 |
| Hesse, B | 1 |
| Christensen, P | 1 |
| Zipser, RD | 1 |
| Rude, RK | 1 |
| Zia, PK | 1 |
| Fichman, MP | 1 |
| Sasaki, H | 1 |
| Radfar, N | 1 |
| Gill, JR | 1 |
| Bravo, E | 1 |
| Taylor, AA | 1 |
| Bowden, RE | 1 |
| Barbour, GL | 1 |
| Day, JO | 1 |
| Galvez, OG | 1 |
| Bay, WH | 1 |
| Roberts, BW | 1 |
| Verberckmoes, R | 1 |
| van Damme B, B | 1 |
| Clement, J | 1 |
| Amery, A | 1 |
| Michielsen, P | 1 |
| Waitman, AD | 1 |
| Koffler, M | 1 |
| Kaplinsky, N | 1 |
| Goren, A | 1 |
| Drachman, R | 1 |
| Hadas-Halperin, I | 1 |
| Drukker, A | 1 |
| Tourniaire, J | 1 |
| Bajard, L | 1 |
| Harfouch, M | 1 |
| Rebattu, B | 1 |
| Garrel, D | 1 |
| Bianchetti, MG | 1 |
| Girardin, E | 1 |
| Benador-Milsztajn, N | 1 |
| Sizonenko, PC | 1 |
| Paunier, L | 2 |
| Rascher, W | 1 |
| Schweer, H | 1 |
| Kühl, PG | 1 |
| Mehls, O | 1 |
| Schärer, K | 1 |
| Blethen, SL | 1 |
| Van Wyk, JJ | 1 |
| Lorentz, WB | 1 |
| Jennette, JC | 1 |
| Favre, L | 1 |
| Williams, G | 1 |
| Favre, H | 1 |
| Vallotton, MB | 1 |
3 reviews available for indomethacin and Hypokalemia
| Article | Year |
|---|---|
[Bartter syndrome and it's neonatal type].
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Bone Diseases, Metabolic; Cal | 2003 |
Bartter's syndrome.
Topics: Adolescent; Adrenalectomy; Bartter Syndrome; Child; Child, Preschool; Diagnosis, Differential; Femal | 1980 |
Prostaglandins and Bartter's syndrome.
Topics: Acidosis; Aldosterone; Bartter Syndrome; Chemical Phenomena; Chemistry; Diet; Female; Humans; Hypera | 1981 |
2 trials available for indomethacin and Hypokalemia
| Article | Year |
|---|---|
Indomethacin, amiloride, or eplerenone for treating hypokalemia in Gitelman syndrome.
Topics: Adolescent; Adult; Amiloride; Blood Pressure; Body Weight; Cross-Over Studies; Dose-Response Relatio | 2015 |
Evaluation of long-term treatment with indomethacin in hereditary hypokalemic salt-losing tubulopathies.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Child; Creatinine; Electrolytes; F | 2001 |
33 other studies available for indomethacin and Hypokalemia
| Article | Year |
|---|---|
Furosemide-induced tubular dysfunction responding to prostaglandin synthesis inhibitor therapy in a child with nephrotic syndrome.
Topics: Alkalosis; Bartter Syndrome; Child, Preschool; Cyclooxygenase Inhibitors; Diuretics; Female; Furosem | 2018 |
Antenatal Bartter syndrome.
Topics: Bartter Syndrome; Chlorides; Fatal Outcome; Female; Humans; Hypokalemia; Hyponatremia; Indomethacin; | 2014 |
[Casual diagnosis of Gitelman's syndrome].
Topics: Adult; Bartter Syndrome; Diuretics, Potassium Sparing; Female; Gitelman Syndrome; Humans; Hypokalemi | 2014 |
Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma.
Topics: Adenoma, Villous; Adult; Cyclooxygenase Inhibitors; Diuretics; Drug Therapy, Combination; Female; Hu | 2017 |
Analyses of subjects with hypokalemic metabolic alkolosis, Gitelman's and Bartter's syndrome.
Topics: Adolescent; Adult; Alkalosis; Bartter Syndrome; Follow-Up Studies; Gitelman Syndrome; Humans; Hypoka | 2008 |
Bartter syndrome presenting as poor weight gain and abdominal mass in an infant.
Topics: Abdomen; Alkalosis; Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Gitelman Syndrome; Hi | 2008 |
Classic Bartter syndrome: a rare cause of failure to thrive in a child.
Topics: Alkalosis; Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Failure to Thrive; Female; Hum | 2012 |
Hypokalemia and prostaglandin overproduction in Bartter's syndrome.
Topics: Aldosterone; Angiotensin II; Bartter Syndrome; Blood Pressure; Dinoprost; Dinoprostone; Female; Huma | 1984 |
Time-dependent changes in inner medullary plasma flow rate during potassium-depletion.
Topics: Animals; Blood Flow Velocity; Glomerular Filtration Rate; Hypokalemia; Indomethacin; Kidney Concentr | 1984 |
[Differential diagnosis of hypokalemia--Bartter's syndrome: clinical aspects and therapy].
Topics: Adolescent; Adult; Bartter Syndrome; Diagnosis, Differential; Female; Humans; Hyperaldosteronism; Hy | 1984 |
Urinary concentrating ability and antidiuretic hormone responsiveness in the potassium-depleted dog.
Topics: Animals; Dinoprostone; Diuresis; Dogs; Female; Hypokalemia; Indomethacin; Kidney; Kidney Concentrati | 1982 |
Free dopamine excretion in disorders with increased prostaglandin synthesis.
Topics: Bartter Syndrome; Catecholamines; Chromatography, High Pressure Liquid; Dopamine; Female; Humans; Hy | 1982 |
The effect of vasopressin in water-loaded hypokalemic patients is prostaglandin-independent.
Topics: Adult; Body Water; Female; Glomerular Filtration Rate; Humans; Hypokalemia; Indomethacin; Kidney Tub | 1981 |
Effect of indomethacin in two siblings with a renin-dependent hypertension, hyperaldosteronism and hypokalemia.
Topics: Adolescent; Adult; Angiotensin II; Drug Therapy, Combination; Female; Humans; Hyperaldosteronism; Hy | 1980 |
Renal concentrating defect in the hypokalemic rat is prostaglandin independent.
Topics: Animals; Depression, Chemical; Hypokalemia; Indomethacin; Kidney; Kidney Concentrating Ability; Pros | 1980 |
Studies on renal function in healthy women with different degrees of induced potassium depletion. 3) Effective roles of prostanoids and angiotensin II in hypokalemic renal dysfunction.
Topics: Angiotensin II; Chlorides; Creatinine; Diuresis; Enalapril; Female; Humans; Hypokalemia; Indomethaci | 1993 |
[Hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria; Bartter's syndrome in Gitelman's variant--case report].
Topics: Adult; Alkalosis; Bartter Syndrome; Humans; Hypokalemia; Indomethacin; Magnesium; Male; Potassium; P | 1995 |
Hypokalemic salt-losing tubulopathy with chronic renal failure and sensorineural deafness.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Child; Child, Preschool; Chro | 2001 |
Indomethacin-responsive pancreatic cholera.
Topics: Adenoma, Islet Cell; Aged; Dehydration; Diarrhea; Female; Gastrins; Humans; Hypercalcemia; Hypokalem | 1977 |
On the pathogenetic role of prostaglandins in Bartter's syndrome.
Topics: Adolescent; Aldosterone; Bartter Syndrome; Female; Humans; Hyperaldosteronism; Hypokalemia; Indometh | 1979 |
Regulation of urinary prostaglandins in Bartter's syndrome.
Topics: Adult; Bartter Syndrome; Humans; Hyperaldosteronism; Hypokalemia; Ibuprofen; Indomethacin; Magnesium | 1979 |
[A clinical study of pathophysiological feature of "Bartter's syndrome" (author's transl)].
Topics: Adult; Angiotensin II; Aspirin; Bartter Syndrome; Blood Pressure; Body Weight; Diet, Sodium-Restrict | 1979 |
Hypokalemia, in Bartter's syndrome and other disorders, produces resistance to vasopressors via prostaglandin overproduction.
Topics: Adolescent; Adult; Angiotensin II; Bartter Syndrome; Blood Pressure; Child; Drug Resistance; Female; | 1978 |
Asymptomatic Bartter's syndrome.
Topics: Angiotensin II; Bartter Syndrome; Drug Therapy, Combination; Humans; Hyperaldosteronism; Hypokalemia | 1978 |
The hemodynamic effects of potassium deficiency in the dog.
Topics: Angiotensin II; Animals; Bicarbonates; Blood Pressure; Blood Volume; Body Weight; Cardiac Output; Do | 1977 |
Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin.
Topics: Adult; Bartter Syndrome; Body Weight; Dose-Response Relationship, Drug; Humans; Hyperaldosteronism; | 1976 |
Bartter's syndrome presenting as pseudomyocardial infarction and pseudogout.
Topics: Angiotensin II; Aspartate Aminotransferases; Bartter Syndrome; Chondrocalcinosis; Creatine Kinase; D | 1992 |
Transient gall bladder dilatation associated with hypokalaemia in a patient with Bartter syndrome.
Topics: Bartter Syndrome; Dilatation, Pathologic; Gallbladder Diseases; Humans; Hyperaldosteronism; Hypokale | 1989 |
[Restoration of insulin sensitivity after correction of hypokalemia due to chronic tubulopathy in a diabetic patient].
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glucose Clamp Technique; Humans; H | 1988 |
Metabolic studies in primary tubular hypomagnesaemia-hypokalaemia.
Topics: Adolescent; Erythrocytes; Humans; Hypokalemia; Indomethacin; Kidney Tubules; Lymphocytes; Magnesium; | 1988 |
Congenital hypokalemia with hypercalciuria in preterm infants: a hyperprostaglandinuric tubular syndrome different from Bartter syndrome.
Topics: Bartter Syndrome; Calcium; Child, Preschool; Chlorides; Diagnosis, Differential; Dinoprostone; Femal | 1985 |
Reversal of Bartter's syndrome by renal transplantation in a child with focal, segmental glomerular sclerosis.
Topics: Alkalosis; Child, Preschool; Female; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Humans | 1985 |
Relationship of renal prostaglandins to distal transport of sodium chloride in normokalemic and hypokalemic man.
Topics: Absorption; Adult; Aged; Bartter Syndrome; Biological Transport; Female; Humans; Hypokalemia; Indome | 1985 |