indomethacin has been researched along with Hypocapnia in 9 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hypocapnia: Clinical manifestation consisting of a deficiency of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We assessed neuromuscular function while using indomethacin to selectively reduce CBF without changes in P ETC O2 and controlled hyperventilation-induced hypocapnia to reduce both CBF and P ETC O2." | 3.83 | Corticospinal excitability is associated with hypocapnia but not changes in cerebral blood flow. ( Ainslie, PN; Cheung, SS; Gabriel, DA; Greenway, MJ; Hartley, GL; O'Leary, DD; Tokuno, CD; Watson, CL, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Shoemaker, LN | 1 |
| Wilson, LC | 1 |
| Lucas, SJE | 1 |
| Machado, L | 1 |
| Walker, RJ | 1 |
| Cotter, JD | 1 |
| Lewis, NC | 1 |
| Bain, AR | 2 |
| MacLeod, DB | 1 |
| Wildfong, KW | 2 |
| Smith, KJ | 1 |
| Willie, CK | 1 |
| Sanders, ML | 1 |
| Numan, T | 1 |
| Morrison, SA | 1 |
| Foster, GE | 1 |
| Stewart, JM | 1 |
| Ainslie, PN | 3 |
| Hartley, GL | 1 |
| Watson, CL | 1 |
| Tokuno, CD | 1 |
| Greenway, MJ | 1 |
| Gabriel, DA | 1 |
| O'Leary, DD | 1 |
| Cheung, SS | 1 |
| Hoiland, RL | 1 |
| Tymko, MM | 1 |
| Monteleone, B | 1 |
| Ivancev, V | 1 |
| Bakovic, D | 1 |
| Obad, A | 1 |
| Breskovic, T | 1 |
| Palada, I | 1 |
| Joyner, MJ | 1 |
| Dujic, Z | 1 |
| Levene, M | 1 |
| Mitkov, D | 1 |
| Bundgaard, H | 1 |
| Jensen, K | 1 |
| Cold, GE | 1 |
| Bergholt, B | 1 |
| Frederiksen, R | 1 |
| Pless, S | 1 |
| Pharris, LJ | 1 |
| Mirro, R | 1 |
| Leffler, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans[NCT02653638] | Early Phase 1 | 80 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Brain Blood Flow Response to Hypercapnia in Healthy Adults: The Effect of Age and Sex[NCT02840851] | 46 participants (Actual) | Observational | 2016-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Hypocapnia
| Article | Year |
|---|---|
Minimising neonatal brain injury: how research in the past five years has changed my clinical practice.
Topics: Animals; Birth Injuries; Brain Diseases; Dexamethasone; Disease Models, Animal; Ethamsylate; Humans; | 2007 |
5 trials available for indomethacin and Hypocapnia
| Article | Year |
|---|---|
Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults.
Topics: Aged; Cerebrovascular Circulation; Cognition; Humans; Hypocapnia; Indomethacin; Perfusion; Young Adu | 2021 |
Impact of hypocapnia and cerebral perfusion on orthostatic tolerance.
Topics: Adult; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Homeostasis; Humans; Hyperven | 2014 |
Carbon dioxide-mediated vasomotion of extra-cranial cerebral arteries in humans: a role for prostaglandins?
Topics: Adolescent; Adult; Carbon Dioxide; Carotid Artery, Internal; Cerebrovascular Circulation; Cyclooxyge | 2016 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of perioperative indomethacin on intracranial pressure, cerebral blood flow, and cerebral metabolism in patients subjected to craniotomy for cerebral tumors.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cerebrovascular Circula | 1996 |
3 other studies available for indomethacin and Hypocapnia
| Article | Year |
|---|---|
Corticospinal excitability is associated with hypocapnia but not changes in cerebral blood flow.
Topics: Adult; Cerebral Cortex; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Evoked Potentials, M | 2016 |
Short chain fatty acid-induced hyperventilation is due to PGF2-alpha.
Topics: Alkalosis; Animals; Carbon Dioxide; Dinoprost; Fatty Acids; Hyperventilation; Hypocapnia; Indomethac | 1993 |
Pial arterioles and hypocapnia.
Topics: Animals; Animals, Newborn; Arterioles; Hypocapnia; Indomethacin; Pia Mater; Prostaglandins; Swine; V | 1992 |