indomethacin has been researched along with Hypertension, Renovascular in 31 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hypertension, Renovascular: Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The behaviour of active (AR) and inactive (IR) renin was studied in 48 hypertensive patients (37 with uncomplicated essential hypertension and 11 with reno-vascular hypertension) treated with indomethacin alone or with AR stimulating (bumetanide, tienilic acid, captopril) and inhibiting (atenolol) drugs before and after indomethacin addition." | 5.05 | Effects of prostaglandins inhibition on changes in active and inactive renin induced by antihypertensive drugs. ( Arzilli, F; Pedrinelli, R; Salvetti, A; Sassano, P; Turini, F, 1982) |
| "Experiments on anesthesized normotensive rats (NR), spontaneous-hypertensive rats (SHR) and rats with experimental renovascular hypertension (RVR) were made to study the effect of prostaglandins (PG) - PGI2, PGE1, PGF2, and indomethacin on systemic hemodynamics, pressor reaction and cardiac component of the baroreflex." | 3.66 | [Hemodynamic reaction of normotensive and hypertensive rats to the administration of prostaglandins and indomethacin]. ( Ismailov, ShI; Val'dman, AV, 1982) |
| " Cumulative dose-response curves to norepinephrine (NE), 5-hydroxytryptamine (5-HT) and potassium chloride (KCl) were elicited on helical strips of abdominal aorta both in the absence and in the presence of prostacyclin synthetase (transylcypromine, TCP, 0." | 1.28 | Contrasting effects of norepinephrine and 5-hydroxytryptamine on contractility of abdominal aorta of two kidney-two clip hypertensive rats. Effects of inhibitors of arachidonic acid metabolic enzymes. ( de la Riva, IJ; Maquieira, MK; Rosón, MI, 1990) |
| "Enalapril treatment did not change urinary immunoreactive prostaglandin E2 (PGE2) excretion and indomethacin did not modify plasma renin activity of enalapril-treated rats." | 1.27 | Effect of enalapril (MK-421), an orally active angiotensin I converting enzyme inhibitor, on blood pressure, active and inactive plasma renin, urinary prostaglandin E2, and kallikrein excretion in conscious rats. ( Genest, J; Gutkowska, J; Schiffrin, EL; Thibault, G, 1984) |
| "When captopril was administered to the rats treated with indomethacin, captopril-induced blood pressure reduction was attenuated only in 2K-1C hypertensive rats." | 1.27 | Different mechanisms maintaining high blood pressure in chronic one-kidney, one-clip, and two-kidney, one-clip hypertensive rats. ( Hashimoto, H; Hiwada, K; Kokubu, T, 1983) |
| "In spontaneously hypertensive rats (SHR), after 1 day of dosing with an angiotensin-converting enzyme (ACE) inhibitor (captopril or enalapril) plus a diuretic (hydrochlorothiazide), a synergistic antihypertensive effect was observed when a second dose of the combination or ACE inhibitor alone but not the diuretic alone was given the next day." | 1.27 | Acute antihypertensive synergism of angiotensin-converting enzyme inhibitors and diuretics. ( Cervoni, P; Chan, PS; Ronsberg, MA, 1984) |
| "Indomethacin pretreatment (2 mg/kg) failed to significantly alter the vasodepressor and renal responses to furosemide in both hypertensive and normal rats." | 1.27 | Antihypertensive and bilateral renal responses to diuretics in 2-kidney, 1-clip Goldblatt hypertensive rats. ( Han, YF; Huang, WC; Tsai, LM; Wu, JN, 1987) |
| "Indomethacin was infused after control measurements, and blood pressure was monitored continuously in conscious rats." | 1.27 | Prostaglandins and sodium balance during the reversal of chronic two-kidney, one clip hypertension in rats. ( Abe, K; Chiba, S; Hagino, T; Kudo, K; Omata, K; Otsuka, Y; Sato, M; Yasujima, M; Yoshinaga, K, 1986) |
| "Treatment with indomethacin, 10 mg/kg, induced hyperresponsiveness to NE in the sham operated rabbits and also produced a further increase in the response in the 3-day clipped rabbits: the enhanced responses with similar levels were not attenuated by AIIA in both groups." | 1.27 | Prostaglandins in enhanced pressor response in renal prehypertensive rabbits. ( Fujie, M; Fujita, H; Ichikawa, S; Kogure, M; Kumakura, H; Murata, K; Nakamura, T; Sato, K; Yagi, A; Yagi, S, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (58.06) | 18.7374 |
| 1990's | 9 (29.03) | 18.2507 |
| 2000's | 3 (9.68) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waeckel, L | 1 |
| Bertin, F | 1 |
| Clavreul, N | 1 |
| Damery, T | 1 |
| Köhler, R | 1 |
| Paysant, J | 1 |
| Sansilvestri-Morel, P | 1 |
| Simonet, S | 1 |
| Vayssettes-Courchay, C | 1 |
| Wulff, H | 1 |
| Verbeuren, TJ | 1 |
| Félétou, M | 1 |
| Sendão Oliveira, AP | 1 |
| Bendhack, LM | 2 |
| Bivol, LM | 1 |
| Vågnes, OB | 1 |
| Iversen, BM | 1 |
| Schiffrin, EL | 1 |
| Gutkowska, J | 2 |
| Thibault, G | 1 |
| Genest, J | 2 |
| Russell, GI | 2 |
| Bing, RF | 2 |
| Swales, JD | 2 |
| Thurston, H | 3 |
| Hashimoto, H | 1 |
| Hiwada, K | 1 |
| Kokubu, T | 1 |
| Chan, PS | 1 |
| Ronsberg, MA | 1 |
| Cervoni, P | 1 |
| Gerber, JG | 1 |
| Olson, RD | 1 |
| Nies, AS | 1 |
| Vandongen, R | 1 |
| O'Dwyer, J | 1 |
| Stahl, RA | 1 |
| Helmchen, U | 2 |
| Paravicini, M | 1 |
| Ritter, LJ | 1 |
| Schollmeyer, P | 1 |
| Taverner, D | 1 |
| Jackson, J | 1 |
| Ismailov, ShI | 1 |
| Val'dman, AV | 1 |
| Salvetti, A | 2 |
| Pedrinelli, R | 1 |
| Sassano, P | 1 |
| Arzilli, F | 1 |
| Turini, F | 1 |
| Stahl, R | 1 |
| Dienemann, H | 1 |
| Besserer, K | 1 |
| Kneissler, U | 1 |
| Schricker, K | 1 |
| Hamann, M | 1 |
| Kurtz, A | 1 |
| Seino, SC | 1 |
| Morera, S | 1 |
| Gorzalczany, SB | 1 |
| Vega, GW | 1 |
| de la Riva, IJ | 2 |
| Bennett, MA | 1 |
| Watt, PA | 1 |
| Taddei, S | 1 |
| Virdis, A | 1 |
| Mattei, P | 1 |
| Cruz, BV | 1 |
| Escalante, B | 1 |
| Callera, GE | 1 |
| Varanda, WA | 1 |
| Tan, SY | 1 |
| Bravo, E | 1 |
| Mulrow, PJ | 1 |
| Boucher, R | 1 |
| Garcia, R | 1 |
| Demassieux, S | 1 |
| Yun, J | 1 |
| Kelly, G | 1 |
| Bartter, FC | 1 |
| Nakamura, T | 2 |
| Prewitt, RL | 1 |
| Rosón, MI | 1 |
| Maquieira, MK | 1 |
| Ma, YH | 1 |
| Dunham, EW | 1 |
| Fujita, T | 1 |
| Huang, WC | 1 |
| Wu, JN | 1 |
| Han, YF | 1 |
| Tsai, LM | 1 |
| Omata, K | 1 |
| Abe, K | 1 |
| Chiba, S | 1 |
| Yasujima, M | 1 |
| Sato, M | 1 |
| Kudo, K | 1 |
| Hagino, T | 1 |
| Yoshinaga, K | 1 |
| Otsuka, Y | 1 |
| Kogure, M | 1 |
| Ichikawa, S | 1 |
| Yagi, S | 1 |
| Sato, K | 1 |
| Fujita, H | 1 |
| Fujie, M | 1 |
| Kumakura, H | 1 |
| Yagi, A | 1 |
| Murata, K | 1 |
| Tanaka, S | 1 |
1 review available for indomethacin and Hypertension, Renovascular
| Article | Year |
|---|---|
Interrelationship between prostaglandins and renin release.
Topics: Animals; Bartter Syndrome; Dogs; Humans; Hypertension, Renovascular; Indomethacin; Kidney; Pressorec | 1981 |
1 trial available for indomethacin and Hypertension, Renovascular
| Article | Year |
|---|---|
Effects of prostaglandins inhibition on changes in active and inactive renin induced by antihypertensive drugs.
Topics: Adult; Atenolol; Bumetanide; Captopril; Cold Temperature; Diuretics; Enzyme Precursors; Female; Glyc | 1982 |
29 other studies available for indomethacin and Hypertension, Renovascular
| Article | Year |
|---|---|
Preserved regulation of renal perfusion pressure by small and intermediate conductance KCa channels in hypertensive mice with or without renal failure.
Topics: Angiotensinogen; Animals; Endothelium, Vascular; Female; Humans; Hypertension, Renovascular; Indomet | 2015 |
Relaxation induced by acetylcholine involves endothelium-derived hyperpolarizing factor in 2-kidney 1-clip hypertensive rat carotid arteries.
Topics: Acetylcholine; Animals; Biological Factors; Carotid Arteries; Cyclic GMP; Cyclooxygenase Inhibitors; | 2004 |
The renal vascular response to ANG II injection is reduced in the nonclipped kidney of two-kidney, one-clip hypertension.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Benzimidazoles; Biphenyl Compounds; Blood Pressure; B | 2005 |
Effect of enalapril (MK-421), an orally active angiotensin I converting enzyme inhibitor, on blood pressure, active and inactive plasma renin, urinary prostaglandin E2, and kallikrein excretion in conscious rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Bloo | 1984 |
Indomethacin or aprotinin infusion: effect on reversal of chronic two-kidney, one-clip hypertension in the conscious rat.
Topics: Animals; Aprotinin; Blood Pressure; Female; Glucose; Hypertension, Renal; Hypertension, Renovascular | 1982 |
Different mechanisms maintaining high blood pressure in chronic one-kidney, one-clip, and two-kidney, one-clip hypertensive rats.
Topics: Aldosterone; Animals; Aprotinin; Blood Pressure; Blood Urea Nitrogen; Captopril; Creatine; Depressio | 1983 |
Acute antihypertensive synergism of angiotensin-converting enzyme inhibitors and diuretics.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aprotinin; Captopril; Dipeptides; Drug Synergism; | 1984 |
Urinary 6-keto PGF1 alpha and PGE2 in two kidney-one clip hypertension in the rat.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprostone; Epoprostenol; Hypertension, Renovascular; Indom | 1984 |
Glomerular prostaglandin formation in two-kidney, one-clip hypertensive rats.
Topics: Animals; Blood Pressure; Constriction; Glomerular Filtration Rate; Hypertension, Renovascular; Indom | 1984 |
Role of the renal medulla in experimental hypertension.
Topics: Animals; Blood Pressure; Diet; Dinoprostone; Ethylamines; Female; Hypertension, Renovascular; Indome | 1984 |
[Hemodynamic reaction of normotensive and hypertensive rats to the administration of prostaglandins and indomethacin].
Topics: Alprostadil; Animals; Dinoprost; Epoprostenol; Hemodynamics; Hypertension; Hypertension, Renovascula | 1982 |
Effect of indomethacin on blood pressure in rats with renovascular hypertension: dependence on plasma renin activity.
Topics: Animals; Blood Pressure; Hypertension, Renal; Hypertension, Renovascular; Indomethacin; Male; Rats; | 1981 |
Prostaglandins are involved in the stimulation of renin gene expression in 2 kidney-1 clip rats.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Gene Expression; Hematocrit; Hypertension, Renov | 1995 |
Renal function conscious one kidney-one clip hypertensive rats. Effect of indomethacin.
Topics: Animals; Blood Pressure; Dinoprostone; Glomerular Filtration Rate; Hypertension, Renovascular; Indom | 1993 |
Impaired endothelium-dependent relaxation in two-kidney, one clip Goldblatt hypertension: effect of vasoconstrictor prostanoids.
Topics: Acetylcholine; Animals; Endothelium, Vascular; Female; Hypertension, Renovascular; In Vitro Techniqu | 1993 |
Vasodilation to acetylcholine in primary and secondary forms of human hypertension.
Topics: Acetylcholine; Blood Vessels; Female; Forearm; Humans; Hyperaldosteronism; Hypertension; Hypertensio | 1993 |
Renal vascular interaction of angiotensin II and prostaglandins in renovascular hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthesia; Angiotensin II; Anim | 1999 |
Impaired relaxation to acetylcholine in 2K-1C hypertensive rat aortas involves changes in membrane hyperpolarization instead of an abnormal contribution of endothelial factors.
Topics: Acetylcholine; Animals; Aorta; Biological Factors; Cyclic GMP; Disease Models, Animal; Endothelium, | 2000 |
Impaired renal prostaglandin E2 biosynthesis in human hypertensive states.
Topics: Angiotensin-Converting Enzyme Inhibitors; Female; Humans; Hyperaldosteronism; Hypertension; Hyperten | 1978 |
Tonin--angiotensin II system in hypertension.
Topics: Angiotensin II; Animals; Antigen-Antibody Reactions; Blood Pressure; Humans; Hypertension; Hypertens | 1978 |
Effect of indomethacin on renal function and plasma renin activity in dogs with chronic renovascular hypertension.
Topics: Animals; Blood Pressure; Dogs; Female; Heart Rate; Hypertension, Renal; Hypertension, Renovascular; | 1979 |
Alteration of endothelial function in arterioles of renal hypertensive rats at two levels of vascular tone.
Topics: Acetylcholine; Animals; Arterioles; Bradykinin; Endothelium, Vascular; Hypertension, Renovascular; I | 1992 |
Contrasting effects of norepinephrine and 5-hydroxytryptamine on contractility of abdominal aorta of two kidney-two clip hypertensive rats. Effects of inhibitors of arachidonic acid metabolic enzymes.
Topics: Animals; Aorta, Abdominal; Aspirin; Blood Pressure; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzy | 1990 |
Postunclipping renal blood flow in one-kidney, one-clip hypertensive rats.
Topics: Animals; Blood Pressure; Constriction; Extracorporeal Circulation; Hemodynamics; Hypertension, Renov | 1990 |
[Frequency of various types of secondary hypertension and pathogenic mechanisms].
Topics: Adrenal Gland Neoplasms; Cushing Syndrome; Diagnosis, Differential; Glycyrrhetinic Acid; Glycyrrhizi | 1990 |
Antihypertensive and bilateral renal responses to diuretics in 2-kidney, 1-clip Goldblatt hypertensive rats.
Topics: Amiloride; Animals; Blood Pressure; Furosemide; Glomerular Filtration Rate; Hypertension, Renovascul | 1987 |
Prostaglandins and sodium balance during the reversal of chronic two-kidney, one clip hypertension in rats.
Topics: Animals; Blood Pressure; Chronic Disease; Hypertension, Renovascular; Indomethacin; Male; Prostaglan | 1986 |
Prostaglandins in enhanced pressor response in renal prehypertensive rabbits.
Topics: Angiotensin II; Animals; Blood Pressure; Dinoprostone; Epoprostenol; Heart Rate; Hypertension, Renov | 1987 |
[The effect of indomethacin on renal cortical blood flow and natriuresis in the ischemic kidney and contralateral kidney of two-kidney Goldblatt hypertensive rabbits].
Topics: Animals; Hypertension, Renovascular; Indomethacin; Kidney Cortex; Male; Natriuresis; Prostaglandins; | 1986 |