indomethacin has been researched along with Hypertension, Renal in 43 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When indomethacin was added to enalapril treatment, a further significant reduction in urinary proteins and fractional albumin clearance was observed." | 2.69 | The antiproteinuric effect of angiotensin antagonism in human IgA nephropathy is potentiated by indomethacin. ( Azzollini, N; Mister, M; Perico, N; Remuzzi, A; Remuzzi, G; Ruggenenti, P; Sangalli, F, 1998) |
| "When captopril was administered to the rats treated with indomethacin, captopril-induced blood pressure reduction was attenuated only in 2K-1C hypertensive rats." | 1.27 | Different mechanisms maintaining high blood pressure in chronic one-kidney, one-clip, and two-kidney, one-clip hypertensive rats. ( Hashimoto, H; Hiwada, K; Kokubu, T, 1983) |
| "2." | 1.25 | Renal prostaglandin synthesis in experimental renal-clip hypertension in the rat. ( Beilin, LJ; Peto, R; Pugsley, D, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (79.07) | 18.7374 |
| 1990's | 4 (9.30) | 18.2507 |
| 2000's | 4 (9.30) | 29.6817 |
| 2010's | 1 (2.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Paula, TD | 1 |
| Silva, BR | 1 |
| Grando, MD | 1 |
| Pernomian, L | 1 |
| do Prado, AF | 1 |
| Bendhack, LM | 2 |
| Liu, KL | 1 |
| Lo, M | 1 |
| Benzoni, D | 1 |
| Mogielnicki, A | 1 |
| Kramkowski, K | 1 |
| Pietrzak, L | 1 |
| Buczko, W | 1 |
| James, DW | 1 |
| Cleland, LG | 1 |
| Robinson, CW | 1 |
| Leonello, PP | 1 |
| Russell, GI | 1 |
| Bing, RF | 1 |
| Swales, JD | 1 |
| Thurston, H | 1 |
| Hashimoto, H | 1 |
| Hiwada, K | 1 |
| Kokubu, T | 1 |
| Jackson, EK | 1 |
| Branch, RA | 1 |
| Oates, JA | 1 |
| Nijkamp, FP | 1 |
| de Jong, W | 1 |
| Vandongen, R | 1 |
| O'Dwyer, J | 1 |
| Barden, A | 1 |
| Ruilope, L | 1 |
| Garcia Robles, P | 1 |
| Bernis, C | 1 |
| Barrientos, A | 1 |
| Alcazar, J | 1 |
| Tresguerres, JA | 1 |
| Sancho, J | 1 |
| Rodicio, JL | 1 |
| Blackshear, JL | 1 |
| Davidman, M | 1 |
| Stillman, MT | 1 |
| Stahl, R | 1 |
| Dienemann, H | 1 |
| Besserer, K | 1 |
| Kneissler, U | 1 |
| Helmchen, U | 1 |
| Dietz, JR | 1 |
| Davis, JO | 1 |
| DeForrest, JM | 1 |
| Freeman, RH | 1 |
| Echtenkamp, SF | 1 |
| Seymour, AA | 1 |
| Suzuki, S | 1 |
| Shapiro, R | 1 |
| Mulrow, PJ | 1 |
| Tan, SY | 1 |
| Lee, J | 1 |
| Choi, KC | 1 |
| Yeum, CH | 1 |
| Kim, W | 1 |
| Yoo, K | 1 |
| Park, JW | 1 |
| Yoon, PJ | 1 |
| Smith, AJ | 1 |
| Gerkens, JF | 1 |
| Dosen, P | 1 |
| Perico, N | 1 |
| Remuzzi, A | 1 |
| Sangalli, F | 1 |
| Azzollini, N | 1 |
| Mister, M | 1 |
| Ruggenenti, P | 1 |
| Remuzzi, G | 1 |
| Callera, GE | 1 |
| Varanda, WA | 1 |
| De Vriese, AS | 1 |
| Van de Voorde, J | 1 |
| Lameire, NH | 1 |
| Vidrio, H | 1 |
| Boucher, R | 1 |
| Garcia, R | 1 |
| Gutkowska, J | 1 |
| Demassieux, S | 1 |
| Genest, J | 1 |
| Yun, J | 1 |
| Kelly, G | 1 |
| Bartter, FC | 1 |
| Klaus, D | 1 |
| Cangiano, JL | 1 |
| Rodriguez-Sargent, C | 1 |
| Martinez-Maldonado, M | 1 |
| Romero, JC | 4 |
| Strong, CG | 4 |
| Pamnani, MB | 1 |
| Simon, G | 1 |
| Overbeck, HW | 1 |
| Muirhead, EE | 1 |
| Germain, GS | 1 |
| Armstrong, FB | 1 |
| Brooks, B | 1 |
| Leach, BE | 1 |
| Byers, LW | 1 |
| Pitcock, JA | 1 |
| Brown, P | 1 |
| Pugsley, D | 1 |
| Beilin, LJ | 2 |
| Peto, R | 2 |
| Manthorpe, T | 1 |
| Pugsley, DJ | 1 |
| Schölkens, BA | 3 |
| Steinbach, R | 1 |
| Ott, CE | 1 |
| Aguilo, JJ | 1 |
| Torres, VE | 1 |
| Xie, PL | 1 |
| Chapleau, MW | 1 |
| McDowell, TS | 1 |
| Hajduczok, G | 1 |
| Abboud, FM | 1 |
| Wong, PC | 1 |
| Price, WA | 1 |
| Reilly, TM | 1 |
| Duncia, JV | 1 |
| Timmermans, PB | 1 |
| Baldoli, E | 1 |
| Bianchi, G | 1 |
| Corsico, N | 1 |
| Di Francesco, GF | 1 |
| Hara, S | 1 |
| Mimura, N | 1 |
| Ng, CF | 1 |
| Gautieri, RF | 1 |
| Lemke, PM | 1 |
| Saeki, S | 1 |
| Ogihara, T | 1 |
| Masugi, F | 1 |
| Kumahara, Y | 1 |
| Megrelishvili, RI | 1 |
| Glezer, GA | 1 |
| Vikhert, AM | 1 |
| Bykovskaia, KN | 1 |
1 review available for indomethacin and Hypertension, Renal
| Article | Year |
|---|---|
Participation of prostaglandins in the control of renin release.
Topics: Absorption; Animals; Arachidonic Acid; Arachidonic Acids; Bartter Syndrome; Chlorides; Electric Stim | 1982 |
1 trial available for indomethacin and Hypertension, Renal
| Article | Year |
|---|---|
The antiproteinuric effect of angiotensin antagonism in human IgA nephropathy is potentiated by indomethacin.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflam | 1998 |
41 other studies available for indomethacin and Hypertension, Renal
| Article | Year |
|---|---|
Relaxation induced by the nitric oxide donor and cyclooxygenase inhibitor NCX2121 in renal hypertensive rat aortas.
Topics: Animals; Aorta, Thoracic; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; | 2017 |
Effect of perindopril on renal medullary hemodynamics in genetically hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase Inhibitors; Dose-Re | 2006 |
N-methylnicotinamide inhibits arterial thrombosis in hypertensive rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Flow Velocity; Blood Pressure; Carotid Arteries; Collag | 2007 |
Reversible renal failure: associated with treatment with a beta-adrenergic receptor blocking drug and non-steroidal anti-inflammatory drugs.
Topics: Acute Kidney Injury; Adrenergic beta-Antagonists; Anti-Inflammatory Agents; Arthritis, Rheumatoid; C | 1982 |
Indomethacin or aprotinin infusion: effect on reversal of chronic two-kidney, one-clip hypertension in the conscious rat.
Topics: Animals; Aprotinin; Blood Pressure; Female; Glucose; Hypertension, Renal; Hypertension, Renovascular | 1982 |
Different mechanisms maintaining high blood pressure in chronic one-kidney, one-clip, and two-kidney, one-clip hypertensive rats.
Topics: Aldosterone; Animals; Aprotinin; Blood Pressure; Blood Urea Nitrogen; Captopril; Creatine; Depressio | 1983 |
Attenuated development of renal hypertension in essential fatty acid-deficient rats.
Topics: Animals; Blood Pressure; Fatty Acids, Essential; Heart Rate; Hypertension, Renal; Indomethacin; Male | 1983 |
Release of prostaglandins during reversal of one-kidney, but not two-kidney, one clip hypertension in the rat.
Topics: Animals; Blood Pressure; Hypertension, Renal; Indomethacin; Kallikreins; Male; Prostaglandins; Rats; | 1983 |
Role of renal prostaglandin E2 in chronic renal disease hypertension.
Topics: Adolescent; Adult; Aldosterone; Dinoprostone; Female; Humans; Hypertension, Renal; Indomethacin; Kid | 1982 |
Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs.
Topics: Acute Kidney Injury; Adult; Age Factors; Aged; Anti-Inflammatory Agents; Arteriosclerosis; Blood Ure | 1983 |
Effect of indomethacin on blood pressure in rats with renovascular hypertension: dependence on plasma renin activity.
Topics: Animals; Blood Pressure; Hypertension, Renal; Hypertension, Renovascular; Indomethacin; Male; Rats; | 1981 |
Effects of indomethacin in dogs with acute and chronic renovascular hypertension.
Topics: Animals; Blood Pressure; Chronic Disease; Dogs; Female; Hypertension, Renal; Indomethacin; Kidney; P | 1981 |
Urinary prostaglandin E2 excretion in chronic renal disease.
Topics: Chronic Disease; Female; Humans; Hypertension, Renal; Indomethacin; Kidney Diseases; Prostaglandins | 1980 |
Impairment of endothelium-dependent vasorelaxation in chronic two-kidney, one clip hypertensive rats.
Topics: Acetylcholine; Animals; Arginine; Atrial Natriuretic Factor; Chronic Disease; Disease Models, Animal | 1995 |
WEB-2086 and indomethacin do not modify blood pressure fall on unclipping hypertensive rats.
Topics: Animals; Azepines; Blood Pressure; Disease Models, Animal; Hypertension, Renal; Indomethacin; Inject | 1994 |
Impaired relaxation to acetylcholine in 2K-1C hypertensive rat aortas involves changes in membrane hyperpolarization instead of an abnormal contribution of endothelial factors.
Topics: Acetylcholine; Animals; Aorta; Biological Factors; Cyclic GMP; Disease Models, Animal; Endothelium, | 2000 |
Effects of connexin-mimetic peptides on nitric oxide synthase- and cyclooxygenase-independent renal vasodilation.
Topics: Acetylcholine; Animals; Biological Factors; Blood Pressure; Connexins; Cyclooxygenase Inhibitors; En | 2002 |
Increased vasodepressor effect of prostaglandins A1 and E1 in renal hypertensive rabbits.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Hypertension, Renal; Indomethacin | 1978 |
Tonin--angiotensin II system in hypertension.
Topics: Angiotensin II; Animals; Antigen-Antibody Reactions; Blood Pressure; Humans; Hypertension; Hypertens | 1978 |
Effect of indomethacin on renal function and plasma renin activity in dogs with chronic renovascular hypertension.
Topics: Animals; Blood Pressure; Dogs; Female; Heart Rate; Hypertension, Renal; Hypertension, Renovascular; | 1979 |
[Conservative therapy of chronic glomerulonephritis].
Topics: Acidosis; Azathioprine; Chlorambucil; Chronic Disease; Chronic Kidney Disease-Mineral and Bone Disor | 1978 |
Modification of experimental renal hypertension in the rat by indomethacin and hydralazine.
Topics: Animals; Disease Models, Animal; Female; Hydralazine; Hypertension, Renal; Indomethacin; Potassium; | 1978 |
The effect of indomethacin blockade of prostaglandin synthesis on blood pressure of normal rabbits and rabbits with renovascular hypertension.
Topics: Animals; Blood Pressure; Creatinine; Depression, Chemical; Glomerular Filtration Rate; Hypertension, | 1977 |
Hypertension and the interrelated renal circulatory effects of prostaglandins and the renin-angiotensin system.
Topics: Angiotensin II; Animals; Bartter Syndrome; Hypertension, Renal; Indomethacin; Kidney; Prostaglandin | 1977 |
Bioassay in vivo for circulating vasoactive agents after renal artery constriction in dogs.
Topics: Animals; Aorta, Abdominal; Blood Gas Analysis; Blood Pressure; Dogs; Electrolytes; Hypertension, Ren | 1976 |
Endocrine-type antihypertensive function of renomedullary interstitial cells.
Topics: Angiotensin II; Animals; Blood Pressure; Cells, Cultured; Connective Tissue; Connective Tissue Cells | 1975 |
Effects of indomethacin in rabbit renovascular hypertension.
Topics: Animals; Blood Pressure; Depression, Chemical; Hypertension, Renal; Indomethacin; Kidney; Prostaglan | 1976 |
Renal prostaglandin synthesis in experimental renal-clip hypertension in the rat.
Topics: Animals; Blood Pressure; Hypertension, Renal; Indomethacin; Male; Prostaglandins E; Rats | 1975 |
Antihypertensive and hypertensive effects of the kidney. Elucidated by treatment with medullary transplants and with blockade either of the reninangiotensin-system or of the prostaglandin biosynthesis.
Topics: Angiotensin II; Animals; Blood Pressure; Depression, Chemical; Female; Hypertension, Renal; Indometh | 1975 |
Renal prostaglandin synthesis in the Goldblatt hypertensive rat.
Topics: Animals; Blood Pressure; Body Weight; Chromatography, Gas; Drinking; Hypertension, Renal; Indomethac | 1975 |
Increase of experimental hypertension following inhibition of prostaglandin biosynthesis.
Topics: Angiotensin II; Animals; Aspirin; Depression, Chemical; Hypertension, Renal; Indomethacin; Male; Mef | 1975 |
Role of prostaglandins in the reversal of one-kidney hypertension in the rabbit.
Topics: Aminohippuric Acids; Animals; Depression, Chemical; Glomerular Filtration Rate; Hypertension, Renal; | 1975 |
Mechanism of decreased baroreceptor activity in chronic hypertensive rabbits. Role of endogenous prostanoids.
Topics: Animals; Carotid Sinus; Epoprostenol; Female; Hypertension, Renal; Indomethacin; Male; Pressorecepto | 1990 |
Antihypertensive mechanism of captopril in renal hypertensive rats: studies with a nonpeptide angiotensin II receptor antagonist and an angiotensin II monoclonal antibody.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies, Monoclonal; Blood Pressure; C | 1989 |
Pharmacological studies of N-(2,5-dimethyl-1H-pyrrol-1-yl)-6-(4-morpholinyl)-3-pyridazinamine hydrochloride (MDL-899), a new long-acting antihypertensive vasodilator.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Avoidance Learn | 1985 |
[Glomerular diseases secondary to diabetes mellitus].
Topics: Adult; Diabetic Nephropathies; Dipyridamole; Humans; Hypertension, Renal; Indomethacin; Kidney Trans | 1988 |
The effect of chronic administration of indomethacin in captopril-treated renal hypertensive rats.
Topics: Animals; Blood Pressure; Captopril; Heart Rate; Hypertension, Renal; Indomethacin; Kinins; Male; Pro | 1988 |
The hypotensive effect of captopril is not mediated by renal medullary lipids.
Topics: Animals; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Hypertension, Renal; Indometha | 1987 |
[Intensifying of experimental hypertension following prostaglandin--biosynthesis--inhibition].
Topics: Angiotensin II; Animals; Blood Pressure; Hypertension, Renal; Indomethacin; Male; Prostaglandin Anta | 1974 |
[Experimental, acute renal hypertension and exogenous angiotensin II administration following premedication with the prostaglandin biosynthesis inhibitor indometacin].
Topics: Acute Disease; Angiotensin II; Animals; Blood Pressure; Dogs; Hypertension, Renal; Indomethacin; Pre | 1974 |
[Effect of indocide on the course of experimental glomerulonephritis].
Topics: Animals; Autoimmune Diseases; Blood Pressure; Blood Proteins; Complement Fixation Tests; Disease Mod | 1972 |