indomethacin has been researched along with Hypertension, Pulmonary in 77 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pathogenesis of monocrotaline-induced pulmonary hypertension is not clear." | 7.67 | Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension. ( Kanisawa, M; Kato, T; Kitamura, H, 1989) |
| "Ethchlorvynol (10 mg/kg) causes transient pulmonary hypertension and an increased permeability pulmonary edema in sheep." | 7.66 | Indomethacin blunts ethchlorvynol-induced pulmonary hypertension but not pulmonary edema. ( Fairman, RP; Falls, RK; Glauser, FL; Millen, JE, 1982) |
| " The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects." | 7.66 | Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981) |
| "Pulmonary artery pressure (PAP), right ventricular hypertrophy (RVH), NO-related relaxation and tissue ET-1 levels in PA were evaluated and compared with control (C)." | 5.29 | Role of nitric oxide and endothelin-1 in monocrotaline-induced pulmonary hypertension in rats. ( Gewitz, MH; Mathew, R; Tun, H; Zeballos, GA, 1995) |
| "Indomethacin pretreatment blocked the rise in thromboxane in lung lymph and arterial plasma and substantially, although not entirely, blocked the rise in pulmonary arterial pressure." | 5.28 | Intravenous injection of propylene glycol causes pulmonary hypertension in sheep. ( Hales, CA; Quinn, DA; Robinson, D, 1990) |
| " Sublingual isoproterenol (Isuprel) has been effective in a few cases but the every-two-hour dosage schedule is inconvenient on a long-term basis." | 5.26 | Primary pulmonary hypertension. Responses to indomethacin, terbutaline, and isoproterenol. ( Person, B; Proctor, RJ, 1979) |
| "Indomethacin purportedly arrests premature labor by inhibiting the production of prostaglandins." | 5.26 | Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn. ( Manchester, D; Margolis, HS; Sheldon, RE, 1976) |
| "To determine the natural history of lung vascular remodeling and cardiac changes in the rat model of persistent pulmonary hypertension syndrome (PPHN) of the newborn, we studied fetal rats subjected to maternal indomethacin administration initiated on day 19 of gestation and continued for 2, 3, or 4 days." | 3.71 | Progressive lung and cardiac changes associated with pulmonary hypertension in the fetal rat. ( Belik, J; Fabris, VE; Pato, MD, 2001) |
| " Because blockade of prostaglandin H synthase (cyclooxygenase) with indomethacin prevents GBS-induced pulmonary hypertension, we reasoned that the salutary effect of indomethacin might be associated with a reduction in the efficacy of bactericidal activity directed against GBS." | 3.68 | Impact of prostaglandin and thromboxane synthesis blockade on disposition of group B streptococcus in lung and liver of intact piglet. ( Aziz, SM; Gillespie, MN; Horstman, SJ; Pauly, TH, 1992) |
| "Oleic acid injection produces acute lung injury and pulmonary hypertension in adult animals." | 3.68 | Hemodynamic effects of oleic acid in newborn lambs: role of arachidonic acid metabolites. ( Schreiber, MD; Soifer, SJ, 1991) |
| " We hypothesized that similar increases in LTC4, detected in the lung parenchyma and pulmonary vascular compartment during cyclooxygenase blockade with indomethacin (INDO), would be observed during an equal increase in pulmonary arterial pressure caused by acute alveolar hypoxia (HYP, 100% N2) or platelet-activating factor (PAF, 10 micrograms into the pulmonary artery)." | 3.68 | Role of leukotriene C4 in pulmonary hypertension: platelet-activating factor vs. hypoxia. ( Davidson, D; Singh, M; Wallace, GF, 1990) |
| "The pathogenesis of monocrotaline-induced pulmonary hypertension is not clear." | 3.67 | Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension. ( Kanisawa, M; Kato, T; Kitamura, H, 1989) |
| " Because Indo may interfere with the hypotensive effect of hydralazine and because hydralazine has been proposed in the treatment of patients with pulmonary hypertension, 7 of these patients also received 0." | 3.67 | Effects of indomethacin on pulmonary hemodynamics and gas exchange in patients with pulmonary artery hypertension, interference with hydralazine. ( Adnot, S; Brun-Buisson, C; de Cremoux, H; Defouilloy, C; Lemaire, F; Piquet, J, 1987) |
| "Ethchlorvynol (10 mg/kg) causes transient pulmonary hypertension and an increased permeability pulmonary edema in sheep." | 3.66 | Indomethacin blunts ethchlorvynol-induced pulmonary hypertension but not pulmonary edema. ( Fairman, RP; Falls, RK; Glauser, FL; Millen, JE, 1982) |
| " The effects of acetaminophen in pregnancy and in the newborn have not been studied extensively; when ingested in usual therapeutic doses, the available data have shown no adverse effects." | 3.66 | Effects of aspirin and acetaminophen in pregnancy and in the newborn. ( Rudolph, AM, 1981) |
| "Forty patients with intact membranes in preterm labor at 23 to 34 weeks' gestation were randomized to receive either intravenous ritodrine or oral indomethacin as the first-line tocolytic agent." | 2.67 | Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor. ( Besinger, RE; Johnson, TR; Keyes, WG; Niebyl, JR, 1991) |
| "To identify the patent ductus arteriosus (PDA) shunt flow pattern using Doppler echocardiography; and to assess whether it could be used to predict the development of clinically significant PDA." | 1.30 | Echocardiographic assessment of patent ductus arteriosus shunt flow pattern in premature infants. ( Shimizu, M; Su, BH; Watanabe, T; Yanagisawa, M, 1997) |
| "Pretreatment with indomethacin, isoproterenol, or nifedipine significantly reduced post-air-embolism lung water content to 85." | 1.30 | Pharmacologic modulation of pulmonary vascular permeability during air embolism. ( Huang, KL; Lin, YC, 1997) |
| "Pretreatment with methylene blue in Group II also resulted in significant pulmonary artery vasoconstriction to even the 10(-6) mol/liter acetylcholine infusion (10." | 1.29 | Endothelium-dependent pulmonary artery responses in chronic heart failure: influence of pulmonary hypertension. ( Bagley, CW; Cycan, A; Fields, J; Mohanty, PK; Pandian, NG; Porter, TR; Taylor, DO, 1993) |
| "Pulmonary artery pressure (PAP), right ventricular hypertrophy (RVH), NO-related relaxation and tissue ET-1 levels in PA were evaluated and compared with control (C)." | 1.29 | Role of nitric oxide and endothelin-1 in monocrotaline-induced pulmonary hypertension in rats. ( Gewitz, MH; Mathew, R; Tun, H; Zeballos, GA, 1995) |
| "We conclude that, in experimental pulmonary embolism, structurally different cyclooxygenase inhibitors aggravate pulmonary hypertension and deteriorate gas exchange by an altered distribution of VA/Q essentially to lung units with a higher than normal VA/Q." | 1.28 | Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism. ( Delcroix, M; Leeman, M; Lejeune, P; Melot, C; Naeije, R, 1992) |
| "Pretreatment with indomethacin abolishes postlavage pulmonary hypertension, preserves a slightly better lung function with higher arterial PO2, and prevents the postlavage peripheral neutropenia found in untreated animals." | 1.28 | Lung injury in a surfactant-deficient lung is modified by indomethacin. ( Bryan, AC; Burger, R; Fung, D, 1990) |
| "Indomethacin prevented the increase in both cyclooxygenase metabolites, but had no effect on the pulmonary hypertension." | 1.28 | Pulmonary hypertensive response to foreign body microemboli. ( Fairman, RP; Farber, HW; Glauser, FL; Millan, JE; Rounds, S, 1990) |
| "Indomethacin pretreatment blocked the rise in thromboxane in lung lymph and arterial plasma and substantially, although not entirely, blocked the rise in pulmonary arterial pressure." | 1.28 | Intravenous injection of propylene glycol causes pulmonary hypertension in sheep. ( Hales, CA; Quinn, DA; Robinson, D, 1990) |
| "Indomethacin pretreatment prevented the initial phase of pulmonary hypertension, the increases in thromboxane and prostacyclin metabolites in lung lymph, and the febrile response to toxin infusion but did not modify the granulocytopenia or the increased pulmonary vascular permeability." | 1.27 | Effects of cyclooxygenase inhibition on the response to group B streptococcal toxin in sheep. ( Brigham, KL; Larsson, LE; Ogletree, ML; Rojas, J; Stahlman, MT, 1983) |
| "Pretreatment with indomethacin or verapamil was also studied, since these drugs block the increase in pulmonary arterial pressure caused by t-bu-OOH." | 1.27 | Pharmacological modification of pulmonary vascular injury: possible role of cAMP. ( Farrukh, IS; Gurtner, GH; Michael, JR, 1987) |
| " After establishing a dose-response relationship, we chose a control dose that produced intermediate hypertensive responses." | 1.27 | Hemodynamic responses of chronically instrumented piglets to bolus injections of group B streptococci. ( Barefield, E; Godoy, G; Gray, BM; Graybar, G; Lyrene, RK; Philips, JB; Sams, JE, 1988) |
| "3 Indomethacin pretreatment prevented the transient decrease in pulmonary removal of [3H]-PGE1 in response to endotoxin, prevented the haemodynamic effects and inhibited prostaglandin synthesis." | 1.27 | Effect of nafazatrom and indomethacin on pulmonary removal of prostaglandin E1 after endotoxin in rabbits. ( Gillis, CN; Havill, AM; Moalli, R, 1987) |
| "Indomethacin purportedly arrests premature labor by inhibiting the production of prostaglandins." | 1.26 | Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn. ( Manchester, D; Margolis, HS; Sheldon, RE, 1976) |
| "Isosorbide dinitrate was the only drug that elicited any reduction in pulmonary artery pressure; pulmonary vascular resistance decreased modestly." | 1.26 | Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension. ( Bambach, D; Fontana, ME; Hermiller, JB; Huss, P; Leier, CV; Magorien, RD; Thompson, MJ; Unverferth, DV, 1982) |
| "Indomethacin was present in fetal blood, and maternal plasma prostaglandin levels were suppressed." | 1.26 | Constriction of the fetal ductus arteriosus after administration of indomethacin to the pregnant ewe. ( Campbell, W; Garriott, J; Levin, DL; Mills, LJ; Parkey, M, 1979) |
| " Sublingual isoproterenol (Isuprel) has been effective in a few cases but the every-two-hour dosage schedule is inconvenient on a long-term basis." | 1.26 | Primary pulmonary hypertension. Responses to indomethacin, terbutaline, and isoproterenol. ( Person, B; Proctor, RJ, 1979) |
| "Systemic hypotension was not observed and the blood pressure in the indomethacintreated cats 1, 2 and 4 h after endotoxin was 30 mmHg higher than in those cats administered endotoxin alone." | 1.25 | The effect of indomethacin on the cardiovascular and metabolic responses to E. coli endotoxin in the cat. ( Parratt, JR; Sturgess, RM, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (55.84) | 18.7374 |
| 1990's | 26 (33.77) | 18.2507 |
| 2000's | 4 (5.19) | 29.6817 |
| 2010's | 4 (5.19) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, VH | 1 |
| Swartz, DD | 1 |
| Rashid, N | 1 |
| Lakshminrusimha, S | 1 |
| Ma, C | 1 |
| Ryan, RM | 1 |
| Morin, FC | 1 |
| Fike, CD | 1 |
| Aschner, JL | 1 |
| Slaughter, JC | 1 |
| Kaplowitz, MR | 1 |
| Zhang, Y | 1 |
| Pfister, SL | 1 |
| Saldeño, YP | 1 |
| Favareto, V | 1 |
| Mirpuri, J | 1 |
| Forrest, AS | 1 |
| Joyce, TC | 1 |
| Huebner, ML | 1 |
| Ayon, RJ | 1 |
| Wiwchar, M | 1 |
| Joyce, J | 1 |
| Freitas, N | 1 |
| Davis, AJ | 1 |
| Ye, L | 1 |
| Duan, DD | 1 |
| Singer, CA | 1 |
| Valencik, ML | 1 |
| Greenwood, IA | 1 |
| Leblanc, N | 1 |
| Schmidt, B | 1 |
| Wright, LL | 1 |
| Davis, P | 1 |
| Solimano, A | 1 |
| Roberts, RS | 1 |
| Tarcan, A | 1 |
| Gürakan, B | 1 |
| Yildirim, S | 1 |
| Ozkiraz, S | 1 |
| Bilezikçi, B | 1 |
| Piper, PJ | 1 |
| Hemming, VG | 1 |
| O'Brien, WF | 2 |
| Fischer, GW | 1 |
| Golden, SM | 1 |
| Noble, SF | 1 |
| Rojas, J | 2 |
| Larsson, LE | 1 |
| Ogletree, ML | 3 |
| Brigham, KL | 5 |
| Stahlman, MT | 1 |
| Seeger, W | 1 |
| Bauer, M | 1 |
| Bhakdi, S | 1 |
| Stahlman, M | 1 |
| Turner, GR | 1 |
| Levin, DL | 4 |
| Niebyl, JR | 2 |
| Cefalo, RC | 1 |
| Lewis, PE | 1 |
| Fletcher, JR | 1 |
| Ramwell, PW | 1 |
| Peterson, MB | 1 |
| Huttemeier, PC | 1 |
| Zapol, WM | 1 |
| Martin, EG | 1 |
| Watkins, WD | 2 |
| Hermiller, JB | 1 |
| Bambach, D | 1 |
| Thompson, MJ | 1 |
| Huss, P | 1 |
| Fontana, ME | 1 |
| Magorien, RD | 1 |
| Unverferth, DV | 1 |
| Leier, CV | 1 |
| Glauser, FL | 3 |
| Fairman, RP | 3 |
| Millen, JE | 1 |
| Falls, RK | 1 |
| Johnstone, MJ | 1 |
| Dalens, B | 1 |
| Dechelotte, P | 1 |
| Gaulme, J | 1 |
| Raynaud, EJ | 1 |
| Lozano González, CH | 1 |
| Galindo Jiménez, P | 1 |
| Pezzotti, MA | 1 |
| Lowenberg Favela, E | 1 |
| Rudolph, AM | 1 |
| Horiguchi, T | 1 |
| Enzan, K | 3 |
| Mitsuhata, H | 1 |
| Murata, M | 1 |
| Suzuki, M | 1 |
| Herget, J | 1 |
| Hampl, V | 1 |
| Povýsilová, V | 1 |
| Slavík, Z | 1 |
| Mouchawar, AM | 1 |
| Kavanagh, BP | 1 |
| Pearl, RG | 1 |
| Porter, TR | 1 |
| Taylor, DO | 1 |
| Cycan, A | 1 |
| Fields, J | 1 |
| Bagley, CW | 1 |
| Pandian, NG | 1 |
| Mohanty, PK | 1 |
| Olson, NC | 1 |
| Kruse-Elliott, KT | 1 |
| Johnson, LW | 1 |
| Huang, YC | 1 |
| Kennedy, TP | 1 |
| Su, YF | 1 |
| Whorton, AR | 1 |
| Piantadosi, CA | 1 |
| Wang, Y | 1 |
| Schultz, E | 1 |
| Mitchell, MD | 1 |
| Stavros, F | 1 |
| Staub, NC | 1 |
| Shouji, K | 1 |
| Inaba, H | 1 |
| Yoshioka, N | 1 |
| Mathew, R | 1 |
| Zeballos, GA | 1 |
| Tun, H | 1 |
| Gewitz, MH | 1 |
| Yamamoto, S | 1 |
| Burman, HP | 1 |
| O'Donnell, CP | 1 |
| Cahill, PA | 1 |
| Robotham, JL | 1 |
| Su, BH | 1 |
| Watanabe, T | 1 |
| Shimizu, M | 1 |
| Yanagisawa, M | 1 |
| Boels, PJ | 1 |
| Gao, B | 1 |
| Deutsch, J | 1 |
| Haworth, SG | 1 |
| Huang, KL | 1 |
| Lin, YC | 1 |
| Moreira, GA | 1 |
| O'Donnell, DC | 1 |
| Tod, ML | 2 |
| Madden, JA | 1 |
| Gordon, JB | 2 |
| Steinhorn, RH | 1 |
| Fabris, VE | 1 |
| Pato, MD | 1 |
| Belik, J | 1 |
| Thorne, JK | 1 |
| Kuida, H | 1 |
| Anderson, FL | 1 |
| Eulderink, F | 1 |
| Mills, LJ | 2 |
| Parkey, M | 1 |
| Garriott, J | 1 |
| Campbell, W | 1 |
| Weinberg, AG | 1 |
| Watanabe, S | 1 |
| Person, B | 1 |
| Proctor, RJ | 1 |
| Wiberg, T | 1 |
| Vaage, J | 1 |
| Scott, E | 1 |
| Weidner, WJ | 1 |
| Manchester, D | 1 |
| Margolis, HS | 1 |
| Sheldon, RE | 1 |
| Díaz-Calderon, O | 1 |
| Velazco-Olivares, M | 1 |
| Danglot-Banck, C | 1 |
| Gómez-Gomez, M | 1 |
| Covarrubias-Villegas, R | 1 |
| Ostensen, J | 1 |
| Hede, R | 1 |
| Myreng, Y | 1 |
| Ege, T | 1 |
| Holtz, E | 1 |
| Delcroix, M | 1 |
| Melot, C | 1 |
| Lejeune, P | 1 |
| Leeman, M | 1 |
| Naeije, R | 1 |
| Jacobson, JM | 1 |
| Michael, JR | 2 |
| Meyers, RA | 1 |
| Bradley, MB | 1 |
| Sciuto, AM | 1 |
| Gurtner, GH | 2 |
| Pauly, TH | 1 |
| Aziz, SM | 1 |
| Horstman, SJ | 1 |
| Gillespie, MN | 1 |
| Schreiber, MD | 1 |
| Soifer, SJ | 1 |
| Shaul, PW | 1 |
| Kinane, B | 1 |
| Farrar, MA | 1 |
| Buja, LM | 1 |
| Magness, RR | 1 |
| Besinger, RE | 1 |
| Keyes, WG | 1 |
| Johnson, TR | 1 |
| Burger, R | 1 |
| Fung, D | 1 |
| Bryan, AC | 1 |
| Farber, HW | 1 |
| Rounds, S | 1 |
| Millan, JE | 1 |
| Davidson, D | 1 |
| Singh, M | 1 |
| Wallace, GF | 1 |
| Quinn, DA | 1 |
| Robinson, D | 1 |
| Hales, CA | 1 |
| Kato, T | 1 |
| Kitamura, H | 1 |
| Kanisawa, M | 1 |
| Morganroth, ML | 2 |
| Till, GO | 1 |
| Schoeneich, S | 1 |
| Ward, PA | 1 |
| Farrukh, IS | 1 |
| Philips, JB | 2 |
| Lyrene, RK | 2 |
| Godoy, G | 1 |
| Graybar, G | 1 |
| Barefield, E | 1 |
| Sams, JE | 1 |
| Gray, BM | 2 |
| Meyrick, B | 3 |
| Perkett, EA | 1 |
| Gillis, CN | 1 |
| Havill, AM | 1 |
| Moalli, R | 1 |
| Huddleston, KW | 1 |
| Dew, A | 1 |
| Adnot, S | 1 |
| Defouilloy, C | 1 |
| Brun-Buisson, C | 1 |
| Piquet, J | 1 |
| de Cremoux, H | 1 |
| Lemaire, F | 1 |
| Huhta, JC | 1 |
| Moise, KJ | 1 |
| Fisher, DJ | 1 |
| Sharif, DS | 1 |
| Wasserstrum, N | 1 |
| Martin, C | 1 |
| Patterson, GA | 1 |
| Rock, P | 1 |
| Mitzner, WA | 1 |
| Adkinson, NF | 1 |
| Sylvester, JT | 1 |
| Stenmark, KR | 1 |
| Remigio, LK | 1 |
| Voelkel, NF | 1 |
| Murphy, RC | 1 |
| Henson, PM | 1 |
| Mathias, MM | 1 |
| Reeves, JT | 1 |
| Niedermeyer, ME | 1 |
| Hammond, B | 1 |
| Monroe, P | 1 |
| Sugarman, H | 1 |
| Davis, D | 1 |
| Walker, JF | 1 |
| Lindsay, RM | 1 |
| Sibbald, WJ | 1 |
| Linton, AL | 1 |
| Parratt, JR | 1 |
| Sturgess, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants[NCT01755728] | Phase 3 | 19 participants (Actual) | Interventional | 2013-01-01 | Completed | ||
| Vaginal Indomethacin Versus Oral Nifedipine for Preterm Labor; a Randomized Controlled Trial[NCT04404686] | Phase 2/Phase 3 | 300 participants (Anticipated) | Interventional | 2020-10-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for indomethacin and Hypertension, Pulmonary
| Article | Year |
|---|---|
Preterm parturition. Prostaglandin synthetase inhibitors.
Topics: Amniotic Fluid; Animals; Aspirin; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, P | 1981 |
Effects of inhibition of prostaglandin synthesis on fetal development, oxygenation, and the fetal circulation.
Topics: Animals; Blood Circulation; Ductus Arteriosus; Female; Fetal Blood; Fetus; Humans; Hypertension, Pul | 1980 |
2 trials available for indomethacin and Hypertension, Pulmonary
| Article | Year |
|---|---|
Ibuprofen prophylaxis in preterm neonates.
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Hypoxia; Ibup | 2002 |
Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor.
Topics: Amniotic Fluid; Diseases in Twins; Female; Fetal Diseases; Humans; Hypertension, Pulmonary; Indometh | 1991 |
73 other studies available for indomethacin and Hypertension, Pulmonary
| Article | Year |
|---|---|
Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension.
Topics: Administration, Inhalation; Aerosols; Animals; Animals, Newborn; Antihypertensive Agents; Blood Pres | 2010 |
Pulmonary arterial responses to reactive oxygen species are altered in newborn piglets with chronic hypoxia-induced pulmonary hypertension.
Topics: Animals; Animals, Newborn; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme System; Enzyme-Linked | 2011 |
Prolonged persistent patent ductus arteriosus: potential perdurable anomalies in premature infants.
Topics: Analysis of Variance; Bronchopulmonary Dysplasia; Cardiac Surgical Procedures; Case-Control Studies; | 2012 |
Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension.
Topics: Animals; Anoctamin-1; Calcium Channel Blockers; Chloride Channel Agonists; Chloride Channels; Cycloo | 2012 |
Persistent pulmonary hypertension in a premature newborn after 16 hours of antenatal indomethacin exposure.
Topics: Adult; Constriction, Pathologic; Diseases in Twins; Ductus Arteriosus; Female; Gestational Age; Huma | 2004 |
The evolution and future horizons of research on the metabolism of arachidonic acid by 5-lipoxygenase.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Acids; Asthma; Epoprostenol; Huma | 1984 |
PG-synthetase inhibitors in obstetrics and after.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Ductus Arteriosus; Ductus Arteriosus, | 1980 |
Studies of short-term pulmonary and peripheral vascular responses induced in oophorectomized sheep by the infusion of a group B streptococcal extract.
Topics: Animals; Blood Pressure; Castration; Endotoxins; Escherichia coli; Female; Femoral Artery; Hypertens | 1984 |
Effects of cyclooxygenase inhibition on the response to group B streptococcal toxin in sheep.
Topics: Animals; Bacterial Toxins; Capillary Permeability; Cyclooxygenase Inhibitors; Fever; Granulocytes; H | 1983 |
Staphylococcal alpha-toxin elicits hypertension in isolated rabbit lungs. Evidence for thromboxane formation and the role of extracellular calcium.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bacterial Toxins; Blood Pressure; Calcimycin; Calcium; | 1984 |
The effects of group B streptococcus and other organisms on the pulmonary vasculature.
Topics: Agranulocytosis; Airway Resistance; Animals; Bacterial Toxins; Capillary Permeability; Endotoxins; E | 1984 |
Prostaglandin synthesis inhibition in persistent pulmonary hypertension of the newborn.
Topics: Animals; Blood Pressure; Ductus Arteriosus, Patent; Female; Fetus; Humans; Hypertension, Pulmonary; | 1984 |
Effects of cyclooxygenase inhibitors on pulmonary vascular responses to endotoxin in unanesthetized sheep.
Topics: Animals; Blood Pressure; Capillary Permeability; Cyclooxygenase Inhibitors; Endotoxins; Escherichia | 1982 |
The role of prostaglandins in endotoxemia: comparisons in response in the nonpregnant, maternal, and fetal models. I. Prostaglandins and the pulmonary effect of experimental endotoxemia.
Topics: Animals; Castration; Endotoxins; Escherichia coli; Female; Hypertension, Pulmonary; Ibuprofen; Indom | 1980 |
Thromboxane mediates acute pulmonary hypertension in sheep extracorporeal perfusion.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Dinoprost; Epoprostenol; Hypertension, Pulmon | 1982 |
Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension.
Topics: Adolescent; Adult; Aspirin; Diazoxide; Dipyridamole; Female; Hemodynamics; Humans; Hydralazine; Hype | 1982 |
Indomethacin blunts ethchlorvynol-induced pulmonary hypertension but not pulmonary edema.
Topics: Animals; Blood Pressure; Diphenhydramine; Ethchlorvynol; Hypertension, Pulmonary; Indomethacin; Phen | 1982 |
A comparison of plasma prostaglandin levels in term and preterm labour.
Topics: Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; Infant, Newborn, Diseases; P | 1981 |
[Maternal treatment with indomethacin and severe neonatal pulmonary hypertension (author's transl)].
Topics: Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; | 1981 |
[Persistent pulmonary hypertension in the newborn caused by prenatal use of prostaglandin inhibitors, (indomethacin). Report of a case].
Topics: Abortion, Threatened; Adult; Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; | 1980 |
Effects of aspirin and acetaminophen in pregnancy and in the newborn.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Animals; Aspirin; Blood Platelets; Female; Fetus; Humans | 1981 |
Heparin-protamine complexes cause pulmonary hypertension in goats.
Topics: Animals; Anticoagulants; Female; Goats; Heparin; Heparin Antagonists; Hypertension, Pulmonary; Indom | 1995 |
Long-term effects of prenatal indomethacin administration on the pulmonary circulation in rats.
Topics: Animals; Female; Hypertension, Pulmonary; Hypoxia; Indomethacin; Lung; Male; Pregnancy; Prenatal Exp | 1995 |
Serum but not plasma produces injury in the perfused rabbit lung.
Topics: Animals; Blood; Blood Physiological Phenomena; Blood Pressure; Blood Proteins; Capillary Permeabilit | 1994 |
Endothelium-dependent pulmonary artery responses in chronic heart failure: influence of pulmonary hypertension.
Topics: Acetylcholine; Aged; Analysis of Variance; Case-Control Studies; Catheterization, Swan-Ganz; Chronic | 1993 |
Effect of 5-lipoxygenase and cyclooxygenase blockade on porcine hemodynamics during continuous infusion of platelet-activating factor.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Blood; Calcimycin; Chromatography, High Pressure Li | 1993 |
Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung.
Topics: Animals; Arachidonic Acids; Benzoquinones; Blood Pressure; Bronchoconstriction; Humans; Hypertension | 1993 |
Pulmonary hypertensive response to rabbit blood components in goats: role of thromboxane.
Topics: Animals; Blood Physiological Phenomena; Chlorpheniramine; Female; Goats; Hemodynamics; Hypertension, | 1993 |
Inhibition of pulmonary hypertensive response after antigen challenge.
Topics: Animals; Antigens; Benzenesulfonates; Blood Pressure; Bronchoconstriction; Cycloheptanes; Cyclooxyge | 1995 |
Role of nitric oxide and endothelin-1 in monocrotaline-induced pulmonary hypertension in rats.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arginine; Calcimycin; Dose-Response Relationship, Dru | 1995 |
Endothelin causes portal and pulmonary hypertension in porcine endotoxemic shock.
Topics: Analysis of Variance; Animals; Bosentan; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; | 1997 |
Echocardiographic assessment of patent ductus arteriosus shunt flow pattern in premature infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Echocardiography, Doppler, Color | 1997 |
ATP-dependent K+ channel activation in isolated normal and hypertensive newborn and adult porcine pulmonary vessels.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Antihypertensive Agents; Cromakalim; Cyclooxygena | 1997 |
Pharmacologic modulation of pulmonary vascular permeability during air embolism.
Topics: Animals; Capillary Permeability; Cyclooxygenase Inhibitors; Hypertension, Pulmonary; Indomethacin; I | 1997 |
Discordant effects of alkalosis on elevated pulmonary vascular resistance and vascular reactivity in lamb lungs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alkalosis, Respiratory; Animals; | 1999 |
Site-specific effect of guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition in isolated lamb lungs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Inhalation; Anim | 2000 |
Progressive lung and cardiac changes associated with pulmonary hypertension in the fetal rat.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Female; Fetal Heart; Hypertension, Pulmonary; | 2001 |
Phenoxybenzamine induced pulmonary hypertension in calves.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Cattle; Cattle Diseases; Hype | 1978 |
[Stiff back and stiff chest. Sectional findings in ankylosing spondylitis].
Topics: Adult; Aminopyrine; Cardiomegaly; Humans; Hypertension, Pulmonary; Indomethacin; Male; Pain; Spine; | 1977 |
Constriction of the fetal ductus arteriosus after administration of indomethacin to the pregnant ewe.
Topics: Animals; Blood Pressure; Ductus Arteriosus; Female; Fetal Diseases; Hypertension, Pulmonary; Indomet | 1979 |
Hemodynamic, pulmonary vascular, and myocardial abnormalities secondary to pharmacologic constriction of the fetal ductus arteriosus. A possible mechanism for persistent pulmonary hypertension and transient tricuspid insufficiency in the newborn infant.
Topics: Animals; Blood Pressure; Blood Vessels; Constriction, Pathologic; Ductus Arteriosus; Fetal Heart; He | 1979 |
[Experimental pulmonary hypertension--with special reference to physiopathology and etiology of pulmonary hypertension caused by monocrotaline].
Topics: Animals; Blood Pressure; Heart Ventricles; Hypertension, Pulmonary; Immunosuppressive Agents; Indome | 1979 |
Primary pulmonary hypertension. Responses to indomethacin, terbutaline, and isoproterenol.
Topics: Adolescent; Blood Pressure; Female; Humans; Hypertension, Pulmonary; Indomethacin; Isoproterenol; Pr | 1979 |
Release of prostaglandin-like substances during elevations of left atrial pressure in the cat.
Topics: Angiotensin II; Animals; Atrial Function; Cats; Hemodynamics; Hydrostatic Pressure; Hypertension, Pu | 1979 |
Effects of indomethacin on pulmonary hemodynamics and extravascular lung water in sheep after pulmonary microembolism.
Topics: Animals; Body Water; Female; Hemodynamics; Hypertension, Pulmonary; Indomethacin; Lung; Prostaglandi | 1979 |
Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn.
Topics: Adolescent; Female; Humans; Hypertension, Pulmonary; Indomethacin; Infant, Newborn; Infant, Newborn, | 1976 |
[Indomethacin in threatening premature labor. Fetal and neonatal cardiovascular effects].
Topics: Cardiovascular Diseases; Female; Fetal Diseases; Humans; Hypertension, Pulmonary; Indomethacin; Infa | 1992 |
Intravenous injection of Albunex microspheres causes thromboxane mediated pulmonary hypertension in pigs, but not in monkeys or rabbits.
Topics: Albumins; Animals; Blood Pressure; Contrast Media; Hypertension, Pulmonary; Indomethacin; Injections | 1992 |
Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dogs; Hypertension, Pulmonary; Indomethacin; Pulmonary | 1992 |
Hyperbaric oxygen toxicity: role of thromboxane.
Topics: Animals; Bronchoalveolar Lavage Fluid; Butylated Hydroxyanisole; Hyperbaric Oxygenation; Hypertensio | 1992 |
Impact of prostaglandin and thromboxane synthesis blockade on disposition of group B streptococcus in lung and liver of intact piglet.
Topics: Animals; Free Radicals; Hypertension, Pulmonary; Indomethacin; Liver; Lung; Methacrylates; Prostagla | 1992 |
Hemodynamic effects of oleic acid in newborn lambs: role of arachidonic acid metabolites.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Chromones; Hemodynamics; Hypertension, Pulmonary; Indom | 1991 |
Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery. Alterations after prolonged hypoxia in the rat.
Topics: Adenylyl Cyclases; Animals; Endothelium, Vascular; Enzyme Activation; Epoprostenol; Guanosine Tripho | 1991 |
Lung injury in a surfactant-deficient lung is modified by indomethacin.
Topics: Animals; Hypertension, Pulmonary; Indoles; Indomethacin; Leukocyte Count; Lung; Neutrophils; Platele | 1990 |
Pulmonary hypertensive response to foreign body microemboli.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Chromone | 1990 |
Role of leukotriene C4 in pulmonary hypertension: platelet-activating factor vs. hypoxia.
Topics: Animals; Cyclooxygenase Inhibitors; Hypertension, Pulmonary; Hypoxia; Indomethacin; Kinetics; Male; | 1990 |
Intravenous injection of propylene glycol causes pulmonary hypertension in sheep.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Blood Pressure; Cardiac | 1990 |
Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Hypertension, Pulmonary; Indome | 1989 |
Eicosanoids are involved in the permeability changes but not the pulmonary hypertension after systemic activation of complement.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Capillary Permeability; Chromatography, High | 1988 |
Pharmacological modification of pulmonary vascular injury: possible role of cAMP.
Topics: Alprostadil; Animals; Cell Membrane Permeability; Cyclic AMP; Hypertension, Pulmonary; Indomethacin; | 1987 |
Hemodynamic responses of chronically instrumented piglets to bolus injections of group B streptococci.
Topics: Animals; Antibodies, Bacterial; Female; Hemodynamics; Hypertension, Pulmonary; Imidazoles; Indometha | 1988 |
Inflammation and models of chronic pulmonary hypertension.
Topics: Animals; Endotoxins; Escherichia coli; Hypertension, Pulmonary; Indomethacin; Lung; Pneumonia; Radia | 1987 |
Effect of nafazatrom and indomethacin on pulmonary removal of prostaglandin E1 after endotoxin in rabbits.
Topics: Alprostadil; Animals; Endotoxins; Escherichia coli; Hemodynamics; Hypertension, Pulmonary; Hypotensi | 1987 |
Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs.
Topics: Animals; Animals, Newborn; Blood Pressure; Hemodynamics; Hypertension, Pulmonary; Indomethacin; Pros | 1986 |
Effects of indomethacin on pulmonary hemodynamics and gas exchange in patients with pulmonary artery hypertension, interference with hydralazine.
Topics: Aged; Cardiac Catheterization; Drug Evaluation; Drug Interactions; Female; Hemodynamics; Humans; Hyd | 1987 |
Detection and quantitation of constriction of the fetal ductus arteriosus by Doppler echocardiography.
Topics: Animals; Constriction, Pathologic; Ductus Arteriosus; Echocardiography; Female; Fetal Diseases; Huma | 1987 |
Effects of imidazole and indomethacin on fluid balance in isolated sheep lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Epoprostenol; Hypertension, Pulmonary; Imidazoles; Indomethac | 1985 |
Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonate Lipoxygenases; Arachidonic Acid; Arachidonic Aci | 1985 |
Pulmonary hypertension and increased vasoreactivity caused by repeated indomethacin in sheep.
Topics: Animals; Cyclooxygenase Inhibitors; Hypertension, Pulmonary; Indomethacin; Lipoxygenase Inhibitors; | 1985 |
Vasoconstriction and remodeling in pulmonary hypertension.
Topics: Animals; Endotoxins; Escherichia coli; Hypertension, Pulmonary; Indomethacin; Prostaglandin-Endopero | 1985 |
The pulmonary hypertension of sclerosing agents is prevented by cyclooxygenase inhibitors.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Drug Combinations; Female; Hypertension, Pulmona | 1985 |
Acute pulmonary hypertension, leucopenia and hypoxia in early haemodialysis.
Topics: Animals; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Hypoxia; Indomethacin; Leu | 1985 |
The effect of indomethacin on the cardiovascular and metabolic responses to E. coli endotoxin in the cat.
Topics: Acidosis; Animals; Arteries; Blood; Blood Glucose; Cardiac Output; Cats; Central Venous Pressure; En | 1974 |