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indomethacin and Hypertension, Malignant

indomethacin has been researched along with Hypertension, Malignant in 1 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Hypertension, Malignant: A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.

Research Excerpts

ExcerptRelevanceReference
"The effect of indomethacin or placebo on aldosterone, plasma renin activity (PRA), sodium excretion, and urinary prostaglandin (PG) levels was investigated in five hypertensive subjects in 100 mEq sodium balance who had experienced malignant hypertension with a disturbance of their renin-aldosterone relationship in the past."5.04Suppression of plasma renin activity by indomethacin in man. ( Dormois, JC; Frölich, BL; Frölich, JC; Hollifield, JW; Michelakis, AM; Oates, JA; Seyberth, H, 1976)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19901 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Frölich, JC1
Hollifield, JW1
Dormois, JC1
Frölich, BL1
Seyberth, H1
Michelakis, AM1
Oates, JA1

Trials

1 trial available for indomethacin and Hypertension, Malignant

ArticleYear
Suppression of plasma renin activity by indomethacin in man.
    Circulation research, 1976, Volume: 39, Issue:3

    Topics: Adult; Aldosterone; Angiotensin II; Clinical Trials as Topic; Depression, Chemical; Female; Furosemi

1976