indomethacin has been researched along with Hypertension, Malignant in 1 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hypertension, Malignant: A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of indomethacin or placebo on aldosterone, plasma renin activity (PRA), sodium excretion, and urinary prostaglandin (PG) levels was investigated in five hypertensive subjects in 100 mEq sodium balance who had experienced malignant hypertension with a disturbance of their renin-aldosterone relationship in the past." | 5.04 | Suppression of plasma renin activity by indomethacin in man. ( Dormois, JC; Frölich, BL; Frölich, JC; Hollifield, JW; Michelakis, AM; Oates, JA; Seyberth, H, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frölich, JC | 1 |
| Hollifield, JW | 1 |
| Dormois, JC | 1 |
| Frölich, BL | 1 |
| Seyberth, H | 1 |
| Michelakis, AM | 1 |
| Oates, JA | 1 |
1 trial available for indomethacin and Hypertension, Malignant
| Article | Year |
|---|---|
Suppression of plasma renin activity by indomethacin in man.
Topics: Adult; Aldosterone; Angiotensin II; Clinical Trials as Topic; Depression, Chemical; Female; Furosemi | 1976 |