indomethacin has been researched along with Hyperplasia in 34 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have shown that agents such as indomethacin and hydrocortisone act to reduce the level of epidermal hyperplasia produced by various chemical, but little information is available about the effects of such anti-inflammatory agents on the induction of hyperplasia in oral mucosa." | 7.67 | Effects of the anti-inflammatory agents indomethacin, metiamide and acetylsalicylic acid on the induction of hyperplasia in hamster cheek-pouch epithelium and ear epidermis. ( Harris, RR; Mackenzie, IC, 1984) |
| "As the nonsteroidal anti-inflammatory drug indomethacin has already been shown to inhibit cigarette smoke (CS)-induced secretory cell hyperplasia in the airway epithelium of the rat, the present study was undertaken to determine the effects of prophylactic interaperitoneal injection of indomethacin (4 mg/kg body weight) compared with each of three steroidal anti-inflammatory drugs given at comparable doses." | 7.67 | Inhibition of cigarette smoke-induced airway secretory cell hyperplasia by indomethacin, dexamethasone, prednisolone, or hydrocortisone in the rat. ( Jeffery, PK; Rogers, DF, 1986) |
| " The short-term (9 days) effect of indomethacin in combination with spironolactone was a suppression of hyperreninemia and hyperaldosteronism and an increase in vascular sensitivity to angiotensin II associated with potassium and sodium retention." | 7.66 | Bartter's syndrome without hyperplasia of the juxtaglomerular apparatus, treated with indomethacin. ( Kornerup, HJ; Pedersen, EB; Petersen, VP, 1978) |
| "During treatment with indomethacin in a patient with Bartter's syndrome, hypokalemia, high plasma renin concentration, hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected." | 7.65 | Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin. ( Amery, A; Clement, J; Michielsen, P; van Damme B, B; Verberckmoes, R, 1976) |
| "Routine rectal administration of 100 mg of diclofenac or indomethacin was demonstrated to be an effective prevention method to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis." | 5.22 | The Incidence and Severity of Post-ERCP Pancreatitis in Patients Receiving Standard Administration of NSAIDs: a Systematic Review and Meta-analysis. ( Chen, Z; Guo, X; Kang, X; Lou, L; Lu, Y; Luo, H; Pan, Y; Zhou, Z, 2022) |
| " 19, (e) the effect of indomethacin, and (f) the role of increased biliary pressure, in the absence of physiological and biochemical evidence of cholestasis, on [3H]thymidine incorporation by the bile-duct cells." | 3.68 | Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat. ( Liu, MH; Slott, PA; Tavoloni, N, 1990) |
| "Previous studies have shown that agents such as indomethacin and hydrocortisone act to reduce the level of epidermal hyperplasia produced by various chemical, but little information is available about the effects of such anti-inflammatory agents on the induction of hyperplasia in oral mucosa." | 3.67 | Effects of the anti-inflammatory agents indomethacin, metiamide and acetylsalicylic acid on the induction of hyperplasia in hamster cheek-pouch epithelium and ear epidermis. ( Harris, RR; Mackenzie, IC, 1984) |
| "As the nonsteroidal anti-inflammatory drug indomethacin has already been shown to inhibit cigarette smoke (CS)-induced secretory cell hyperplasia in the airway epithelium of the rat, the present study was undertaken to determine the effects of prophylactic interaperitoneal injection of indomethacin (4 mg/kg body weight) compared with each of three steroidal anti-inflammatory drugs given at comparable doses." | 3.67 | Inhibition of cigarette smoke-induced airway secretory cell hyperplasia by indomethacin, dexamethasone, prednisolone, or hydrocortisone in the rat. ( Jeffery, PK; Rogers, DF, 1986) |
| "A four-year-old girl with growth failure and clinical and laboratory evidence of Bartter's syndrome responded to indomethacin treatment with decreased urinary prostaglandin excretion, symptomatic and chemical improvement, and accelerated growth." | 3.67 | Reversal of Bartter's syndrome by renal transplantation in a child with focal, segmental glomerular sclerosis. ( Blethen, SL; Jennette, JC; Lorentz, WB; Van Wyk, JJ, 1985) |
| "The effect of the anti-inflammatory agent indomethacin on the response of bronchial epithelium to irritation by tobacco smoke has been studied using the specific pathogen free rat as an experimental animal model of bronchitis." | 3.66 | The effect of indomethacin on the response of bronchial epithelium to tobacco smoke. ( Ayers, M; Greig, N; Jeffery, PK, 1980) |
| "Sequential changes in skin metabolism have been studied in a model system of epidermal hyperplasia and hyperkeratinization induced by the application of n-hexadecane to shaved rat skin." | 3.66 | The relationship between cyclic adenosine 3', 5' - monophosphate and biochemical events in rat skin after the induction of epidermal hyperplasia using hexadecane. ( Peters, RF; White, AM, 1978) |
| " The short-term (9 days) effect of indomethacin in combination with spironolactone was a suppression of hyperreninemia and hyperaldosteronism and an increase in vascular sensitivity to angiotensin II associated with potassium and sodium retention." | 3.66 | Bartter's syndrome without hyperplasia of the juxtaglomerular apparatus, treated with indomethacin. ( Kornerup, HJ; Pedersen, EB; Petersen, VP, 1978) |
| "During treatment with indomethacin in a patient with Bartter's syndrome, hypokalemia, high plasma renin concentration, hyperaldosteronism and decreased sensitivity to angiotensin infusion were corrected." | 3.65 | Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin. ( Amery, A; Clement, J; Michielsen, P; van Damme B, B; Verberckmoes, R, 1976) |
| "Lung cancer is the leading cause of cancer-related death worldwide." | 1.38 | Non-invasive X-ray micro-computed tomographic evaluation of indomethacin on urethane-induced lung carcinogenesis in mice. ( Hayakawa, T; Imai, T; Imaida, K; Komiya, M; Mutoh, M; Takahashi, M; Tsuta, K; Ueno, T; Wakabayashi, K; Yanaka, A; Yoshimoto, M, 2012) |
| "Esophageal and tongue cancers have both been associated with dietary zinc deficiency (ZD), and cyclooxygenase (COX-2) is often overexpressed in these cancers." | 1.33 | Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. ( Farber, JL; Fong, LY; Jiang, Y; Zhang, L, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (47.06) | 18.7374 |
| 1990's | 11 (32.35) | 18.2507 |
| 2000's | 5 (14.71) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, X | 1 |
| Guo, X | 2 |
| Chen, Z | 1 |
| Zhou, Z | 1 |
| Luo, H | 1 |
| Lu, Y | 1 |
| Lou, L | 1 |
| Pan, Y | 1 |
| Ueno, T | 1 |
| Imaida, K | 2 |
| Yoshimoto, M | 1 |
| Hayakawa, T | 1 |
| Takahashi, M | 1 |
| Imai, T | 1 |
| Yanaka, A | 1 |
| Tsuta, K | 1 |
| Komiya, M | 1 |
| Wakabayashi, K | 1 |
| Mutoh, M | 1 |
| Sandow, SL | 1 |
| Bramich, NJ | 1 |
| Bandi, HP | 1 |
| Rummery, NM | 1 |
| Hill, CE | 1 |
| Fischer, JW | 1 |
| Hawkins, S | 1 |
| Clowes, AW | 1 |
| van den Hoff, MJ | 1 |
| Deprez, RH | 1 |
| Ruijter, JM | 1 |
| de Boer, PA | 1 |
| Tesink-Taekema, S | 1 |
| Buffing, AA | 1 |
| Lamers, WH | 1 |
| Moorman, AF | 1 |
| Fong, LY | 1 |
| Zhang, L | 1 |
| Jiang, Y | 1 |
| Farber, JL | 1 |
| Harris, RR | 1 |
| Mackenzie, IC | 1 |
| Boutwell, RK | 1 |
| Marks, F | 1 |
| Berry, DL | 1 |
| Bertsch, S | 1 |
| Fürstenberger, G | 1 |
| Richter, H | 1 |
| Schelling, SH | 1 |
| Wolfe, HJ | 1 |
| Tashjian, AH | 1 |
| Greig, N | 1 |
| Ayers, M | 1 |
| Jeffery, PK | 2 |
| Shibata, M | 1 |
| Hasegawa, R | 2 |
| Hagiwara, A | 1 |
| Ogawa, K | 1 |
| Hirose, M | 2 |
| Ito, N | 2 |
| Shirai, T | 2 |
| De, S | 1 |
| Zelazny, ET | 1 |
| Souhrada, JF | 1 |
| Souhrada, M | 1 |
| Shibata, MA | 2 |
| Takesada, Y | 1 |
| Fukushima, S | 2 |
| LePard, KJ | 1 |
| Mohammed, JR | 1 |
| Stephens, RL | 1 |
| Włodarski, K | 1 |
| Luczak, M | 1 |
| Galus, R | 1 |
| Włodarski, P | 1 |
| Davies, MG | 1 |
| Huynh, TT | 1 |
| Hagen, PO | 1 |
| Peters, RF | 1 |
| White, AM | 1 |
| Ziboh, VA | 1 |
| Lord, JT | 1 |
| Blick, G | 1 |
| Kursunoglu, I | 1 |
| Poitier, J | 1 |
| Yunis, AA | 1 |
| Weirich, EG | 1 |
| Longauer, JK | 1 |
| Kirkwood, AH | 1 |
| Kornerup, HJ | 1 |
| Pedersen, EB | 1 |
| Petersen, VP | 1 |
| Verberckmoes, R | 1 |
| van Damme B, B | 1 |
| Clement, J | 1 |
| Amery, A | 1 |
| Michielsen, P | 1 |
| Goerttler, K | 1 |
| Edler, L | 1 |
| Loehrke, H | 1 |
| Asakawa, E | 1 |
| Slott, PA | 1 |
| Liu, MH | 1 |
| Tavoloni, N | 1 |
| Viluksela, M | 1 |
| Lichtman, SN | 1 |
| Sartor, RB | 1 |
| Lauriault, V | 1 |
| Grasso, P | 1 |
| Powell, CJ | 1 |
| Wei, WZ | 1 |
| Fulton, A | 1 |
| Malone, K | 1 |
| Heppner, G | 1 |
| Giao, NB | 1 |
| Chouroulinkov, I | 1 |
| Truhaut, R | 1 |
| Katz, PO | 1 |
| Geisinger, KR | 1 |
| Hassan, M | 1 |
| Wu, WC | 1 |
| Huang, D | 1 |
| Castell, DO | 1 |
| Rogers, DF | 1 |
| Blethen, SL | 1 |
| Van Wyk, JJ | 1 |
| Lorentz, WB | 1 |
| Jennette, JC | 1 |
| Westmoreland, N | 1 |
| Hoekstra, WG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Rectal Disclofenac Versus Indomethacin for Prevention of Post-ERCP Pancreatitis (DIPPP): A Multicentre, Double-blind, Randomised, Controlled Trial[NCT05947461] | 3,612 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for indomethacin and Hyperplasia
| Article | Year |
|---|---|
The Incidence and Severity of Post-ERCP Pancreatitis in Patients Receiving Standard Administration of NSAIDs: a Systematic Review and Meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cholangiopancreatography, Endoscopic Retrograde; Diclofenac | 2022 |
33 other studies available for indomethacin and Hyperplasia
| Article | Year |
|---|---|
Non-invasive X-ray micro-computed tomographic evaluation of indomethacin on urethane-induced lung carcinogenesis in mice.
Topics: Adenocarcinoma; Adenoma; Animals; Antineoplastic Agents; Carcinogens; Humans; Hyperplasia; Immunohis | 2012 |
Structure, function, and endothelium-derived hyperpolarizing factor in the caudal artery of the SHR and WKY rat.
Topics: Acetylcholine; Animals; Apamin; Arteries; Biological Factors; Charybdotoxin; Endothelium, Vascular; | 2003 |
Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in balloon-injured rat carotid arteries.
Topics: Angioplasty, Balloon; Animals; Carotid Arteries; Carotid Artery Injuries; Cyclooxygenase Inhibitors; | 2004 |
Increased cardiac workload by closure of the ductus arteriosus leads to hypertrophy and apoptosis rather than to hyperplasia in the late fetal period.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Apoptosis; Body Weight; Bromodeox | 2004 |
Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Ce | 2005 |
Effects of the anti-inflammatory agents indomethacin, metiamide and acetylsalicylic acid on the induction of hyperplasia in hamster cheek-pouch epithelium and ear epidermis.
Topics: Animals; Aspirin; Cricetinae; Ear, External; Epidermis; Hyperplasia; Indomethacin; Mesocricetus; Met | 1984 |
On the role of tumour promotion in chemical carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dexamethasone; DNA Replication; Hyperplasia; | 1984 |
On the relationship between epidermal hyperproliferation and skin tumor promotion.
Topics: Calcimycin; Cell Division; Cocarcinogenesis; Dinoprost; Dinoprostone; Epidermal Cells; Hyperplasia; | 1982 |
Role of the osteoclast in prostaglandin E2-stimulated bone resorption: a correlative morphometric and biochemical analysis.
Topics: Animals; Bone Resorption; Calcium; Hyperplasia; Indomethacin; Mice; Microscopy, Electron; Organ Cult | 1980 |
The effect of indomethacin on the response of bronchial epithelium to tobacco smoke.
Topics: Animals; Bronchitis; Cell Count; Epithelium; Hyperplasia; Indomethacin; Lung; Mucous Membrane; Nicot | 1980 |
Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Dehydroepiandrosterone; Disease Models, Animal; Hyperplasia; Indom | 1995 |
IL-1 beta and IL-6 induce hyperplasia and hypertrophy of cultured guinea pig airway smooth muscle cells.
Topics: Animals; DNA; Guinea Pigs; Hyperplasia; Hypertrophy; Indomethacin; Interleukin-1; Interleukin-6; Mal | 1995 |
Chemoprevention by indomethacin of tumor promotion in a rat urinary bladder carcinogenesis model.
Topics: Animals; Ascorbic Acid; Butylated Hydroxyanisole; Cell Division; Dinoprostone; Drug Screening Assays | 1993 |
Gastric ECL-cell hyperplasia produces enhanced basal and stimulated gastric acid output but not gastric erosion formation in the rat.
Topics: Animals; Carbachol; Enterochromaffin Cells; Female; Gastric Acid; Gastric Mucosa; Histamine; Hyperpl | 1997 |
Local hypertrophic/hyperplastic changes of keratinizing squamous epithelium of pinna induced by concanavalin A and other immunomodulators in mice.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Transplantatio | 1999 |
Characterization of dopamine-mediated relaxation in experimental vein bypass grafts.
Topics: Adjuvants, Immunologic; Adrenergic alpha-Antagonists; Animals; Cardiotonic Agents; Cardiovascular Ag | 2000 |
The relationship between cyclic adenosine 3', 5' - monophosphate and biochemical events in rat skin after the induction of epidermal hyperplasia using hexadecane.
Topics: Administration, Topical; Alkanes; Animals; Anti-Inflammatory Agents; Cyclic AMP; DNA; Epidermis; Gly | 1978 |
Alteration of prostaglandin biosynthesis in rat chloroleukemic tumor.
Topics: Animals; Arachidonic Acids; Bone Marrow; Fatty Acids, Unsaturated; Hydroxyprostaglandin Dehydrogenas | 1977 |
Epidermal antihyperplastic effects of contact antiphlogistics.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Bufexamac; Fluocinolone Acetonide; Guinea Pigs; Hydrocor | 1978 |
Bartter's syndrome without hyperplasia of the juxtaglomerular apparatus, treated with indomethacin.
Topics: Adult; Bartter Syndrome; Diet, Sodium-Restricted; Drug Evaluation; Humans; Hyperaldosteronism; Hyper | 1978 |
Bartter's syndrome with hyperplasia of renomedullary cells: successful treatment with indomethacin.
Topics: Adult; Bartter Syndrome; Body Weight; Dose-Response Relationship, Drug; Humans; Hyperaldosteronism; | 1976 |
Long term tumorigenicity of a single application of indomethacin or Amuno in adolescent and in adult male Sprague Dawley rats.
Topics: Aging; Animals; Body Weight; Epidermis; Hyperplasia; Indomethacin; Leydig Cell Tumor; Liver Neoplasm | 1992 |
The modifying effects of indomethacin or ascorbic acid on cell proliferation induced by different types of bladder tumor promoters in rat urinary bladder and forestomach mucosal epithelium.
Topics: Animals; Ascorbic Acid; Butylated Hydroxyanisole; Carcinogens; Cell Division; Citrates; Citric Acid; | 1992 |
Origin, pattern, and mechanism of bile duct proliferation following biliary obstruction in the rat.
Topics: Animals; Autoradiography; Bile Ducts, Intrahepatic; Cell Division; Cholestasis; Common Bile Duct; Hy | 1990 |
Characteristics and modulation of dithranol (anthralin)-induced skin irritation in the mouse ear model.
Topics: Administration, Topical; Adrenal Cortex Hormones; Animals; Anthralin; Anti-Inflammatory Agents, Non- | 1991 |
Duct proliferation following biliary obstruction in the rat.
Topics: Animals; Bile Ducts; Cholestasis; Hyperplasia; Indomethacin; Kupffer Cells; Rats | 1991 |
Butylated hydroxyanisole (BHA) does not cause forestomach hyperplasia by inhibiting the release of gastric mucus.
Topics: Administration, Oral; Animals; Body Weight; Brunner Glands; Butylated Hydroxyanisole; Cyclooxygenase | 1990 |
Modulation of lymphocytic infiltrates in C4 mouse mammary tumors.
Topics: Animals; Cell Movement; Dinoprostone; Female; Hyperplasia; Indomethacin; Interleukin-2; Mammary Glan | 1989 |
[Epigenetic mechanism of tumor promotion. Interrelationship between inflammation and ornithine decarboxylase activity induced in vitro by the carcinogenic 12-O-tetradecanoyl-phorbol-13-acetate].
Topics: Animals; Dexamethasone; Epidermis; Female; Hyperplasia; Indomethacin; Inflammation; Mice; Mice, Inbr | 1988 |
Acid-induced esophagitis in cats is prevented by sucralfate but not synthetic prostaglandin E.
Topics: Animals; Cats; Esophagitis, Peptic; Esophagoscopy; Esophagus; Hydrochloric Acid; Hyperplasia; Indome | 1988 |
Inhibition of cigarette smoke-induced airway secretory cell hyperplasia by indomethacin, dexamethasone, prednisolone, or hydrocortisone in the rat.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Cell Count; Dexamethasone; Hydrocortisone; Hyperplas | 1986 |
Reversal of Bartter's syndrome by renal transplantation in a child with focal, segmental glomerular sclerosis.
Topics: Alkalosis; Child, Preschool; Female; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Humans | 1985 |
Pathological defects in the epiphyseal cartilage of zinc-deficient chicks.
Topics: Animals; Cartilage Diseases; Chickens; Deficiency Diseases; Diet; Epiphyses; Histamine; Hyperplasia; | 1969 |