indomethacin has been researched along with Hyperkalemia in 30 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hyperkalemia: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence and severity of hyperkalemia and azotemia was investigated in a prospective randomized study involving 74 patients receiving either sulindac 200 mg p." | 9.06 | Reduced incidence of hyperkalemia and azotemia in patients receiving sulindac compared with indomethacin. ( Hershko, C; Nesher, G; Zimran, A, 1988) |
| "We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function." | 7.67 | Hyperkalemia induced by indomethacin and naproxen and reversed by fludrocortisone. ( Khanna, R; Mactier, RA, 1988) |
| "Treatment with a combination of indomethacin and potassium chloride supplementation resulted in severe hyperkalemia in a patient with Bartter's syndrome." | 7.67 | Severe hyperkalemia caused by indomethacin and potassium supplementation. ( Afrasiabi, A; Akbarpour, F; Vaziri, ND, 1985) |
| "3 patients with multiple myeloma developed hyperkalemic hypoaldosteronism and renal insufficiency while receiving indomethacin for bone pain." | 7.66 | Indomethacin-induced hyperkalemia and renal failure in multiple myeloma. ( Paladini, G; Tonazzi, C, 1982) |
| "Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice." | 7.66 | Indomethacin- and Moduretic--induced hyperkalemia. ( Mor, R; Pitlik, S; Rosenfeld, JB, 1983) |
| "We noted five cases of reversible acute deterioration of renal function in patients with very mild to moderate renal insufficiency who received indomethacin for an acute gouty attack." | 7.66 | Reversible acute renal insufficiency and hyperkalemia following indomethacin therapy. ( Folkert, VW; Galler, M; Schlondorff, D, 1981) |
| "We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin." | 7.66 | Indomethacin-induced hyperkalemia in three patients with gouty arthritis. ( Beckstrom, D; Findling, JW; Itskovitz, H; Kozin, F; Rawsthorne, L, 1980) |
| "Hyporeninemic hypoaldosteronism was diagnosed in a young woman with glomerulonephritis who was receiving indomethacin therapy." | 7.66 | Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism. ( Franco, R; Mulrow, PJ; Shapiro, R; Stockard, H; Tan, SY, 1979) |
| " The dosage of cation exchange resins was decreased, oral fluids were tolerated, and the patient's general condition improved." | 5.29 | Effect of hydrochlorothiazide in pseudohypoaldosteronism with hypercalciuria and severe hyperkalemia. ( Rosa, FC; Stone, RC; Vale, P, 1996) |
| "The incidence and severity of hyperkalemia and azotemia was investigated in a prospective randomized study involving 74 patients receiving either sulindac 200 mg p." | 5.06 | Reduced incidence of hyperkalemia and azotemia in patients receiving sulindac compared with indomethacin. ( Hershko, C; Nesher, G; Zimran, A, 1988) |
| "We present a patient in whom indomethacin treatment for acute gouty arthritis induced reversible azotaemia and hyperkalaemia." | 5.05 | Indomethacin-induced azotaemia and hyperkalaemia: a case study. ( Espiner, EA; Nicholls, MG, 1981) |
| "My colleagues and I have found in the porcine coronary artery that the pathway other than the nitric oxide (NG-nitro-L-arginine [L-NNA]-sensitive) and cyclooxygenase (indomethacin-sensitive) pathways of endothelium-dependent relaxation, related to the endothelium-derived hyperpolarizing factor (K+ channel-related), are altered after exposure to hyperkalemia." | 3.69 | Hyperkalemia exposure impairs EDHF-mediated endothelial function in the human coronary artery. ( He, GW, 1997) |
| "We have described a patient with severe rheumatoid arthritis and a history of mefenamic acid nephropathy in whom hyperkalemia and inappropriate hypoaldosteronism were caused by both indomethacin and naproxen, without major decline in renal function." | 3.67 | Hyperkalemia induced by indomethacin and naproxen and reversed by fludrocortisone. ( Khanna, R; Mactier, RA, 1988) |
| "Treatment with a combination of indomethacin and potassium chloride supplementation resulted in severe hyperkalemia in a patient with Bartter's syndrome." | 3.67 | Severe hyperkalemia caused by indomethacin and potassium supplementation. ( Afrasiabi, A; Akbarpour, F; Vaziri, ND, 1985) |
| "3 patients with multiple myeloma developed hyperkalemic hypoaldosteronism and renal insufficiency while receiving indomethacin for bone pain." | 3.66 | Indomethacin-induced hyperkalemia and renal failure in multiple myeloma. ( Paladini, G; Tonazzi, C, 1982) |
| "Simultaneous administration of indomethacin and Moduretic (Merck Sharp & Dohme, USA, 5 mg of amiloride HCl, 50 mg hydrochlorothiazide) to a 78-yr-old patient resulted in severe hyperkalemia twice." | 3.66 | Indomethacin- and Moduretic--induced hyperkalemia. ( Mor, R; Pitlik, S; Rosenfeld, JB, 1983) |
| "We noted five cases of reversible acute deterioration of renal function in patients with very mild to moderate renal insufficiency who received indomethacin for an acute gouty attack." | 3.66 | Reversible acute renal insufficiency and hyperkalemia following indomethacin therapy. ( Folkert, VW; Galler, M; Schlondorff, D, 1981) |
| "We describe three patients in whom severe, life-threatening hyperkalemia and renal insufficiency developed after treatment of acute gouty arthritis with indomethacin." | 3.66 | Indomethacin-induced hyperkalemia in three patients with gouty arthritis. ( Beckstrom, D; Findling, JW; Itskovitz, H; Kozin, F; Rawsthorne, L, 1980) |
| "Hyporeninemic hypoaldosteronism was diagnosed in a young woman with glomerulonephritis who was receiving indomethacin therapy." | 3.66 | Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism. ( Franco, R; Mulrow, PJ; Shapiro, R; Stockard, H; Tan, SY, 1979) |
| " The dosage of cation exchange resins was decreased, oral fluids were tolerated, and the patient's general condition improved." | 1.29 | Effect of hydrochlorothiazide in pseudohypoaldosteronism with hypercalciuria and severe hyperkalemia. ( Rosa, FC; Stone, RC; Vale, P, 1996) |
| " Serum indomethacin levels confirmed that indomethacin was well absorbed transperitoneally." | 1.28 | Indomethacin does not impair cellular potassium uptake in the rat. ( Akrawi, A; Spital, A, 1990) |
| "Hyperkalemia is a common and potentially dangerous condition in elderly patients." | 1.27 | Hyperkalemia in the elderly. ( Booth, J; Cain, M; McCarthy, PJ; Walmsley, RN; White, GH, 1984) |
| "A patient with mild chronic renal failure developed significant hyperkalaemia while receiving indomethacin therapy." | 1.26 | Indomethacin-induced hyperkalaemia. ( Frost, GW; MacCarthy, EP; Strokes, GS, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (76.67) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 1 (3.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schütt, B | 1 |
| Kunz, M | 1 |
| Blode, H | 1 |
| Walmsley, RN | 1 |
| White, GH | 1 |
| Cain, M | 1 |
| McCarthy, PJ | 1 |
| Booth, J | 1 |
| Paladini, G | 1 |
| Tonazzi, C | 1 |
| Meier, DE | 1 |
| Myers, WM | 1 |
| Swenson, R | 1 |
| Bennet, WM | 1 |
| Mor, R | 1 |
| Pitlik, S | 1 |
| Rosenfeld, JB | 1 |
| Kutyrina, IM | 1 |
| Androsova, SO | 1 |
| Goldszer, RC | 1 |
| Coodley, EL | 1 |
| Rosner, MJ | 1 |
| Simons, WM | 1 |
| Schwartz, AB | 1 |
| Galler, M | 1 |
| Folkert, VW | 1 |
| Schlondorff, D | 1 |
| Nicholls, MG | 1 |
| Espiner, EA | 1 |
| Findling, JW | 1 |
| Beckstrom, D | 1 |
| Rawsthorne, L | 1 |
| Kozin, F | 1 |
| Itskovitz, H | 1 |
| Stone, RC | 1 |
| Vale, P | 1 |
| Rosa, FC | 1 |
| He, GW | 2 |
| Yang, CQ | 1 |
| Yang, JA | 1 |
| Tan, SY | 1 |
| Shapiro, R | 1 |
| Franco, R | 1 |
| Stockard, H | 1 |
| Mulrow, PJ | 1 |
| MacCarthy, EP | 2 |
| Frost, GW | 1 |
| Strokes, GS | 1 |
| Beroniade, V | 1 |
| Cornielle, L | 1 |
| Haraoui, B | 1 |
| Stokes, GS | 1 |
| Klaus, D | 1 |
| Van Buren, M | 1 |
| Van Rijn, HJ | 1 |
| Koomans, HA | 1 |
| Heeg, JE | 1 |
| de Jong, PE | 2 |
| Vriesendorp, R | 1 |
| de Zeeuw, D | 1 |
| Spital, A | 1 |
| Akrawi, A | 1 |
| Blaser, KU | 1 |
| Lämmle, B | 1 |
| Nesher, G | 1 |
| Zimran, A | 2 |
| Hershko, C | 2 |
| Mactier, RA | 1 |
| Khanna, R | 1 |
| Roy, LF | 1 |
| Leenen, FH | 1 |
| Mathews, A | 1 |
| Bailie, GR | 1 |
| Kramer, M | 1 |
| Plaskin, M | 1 |
| Reeves, WB | 1 |
| Foley, RJ | 1 |
| Weinman, EJ | 1 |
| Akbarpour, F | 1 |
| Afrasiabi, A | 1 |
| Vaziri, ND | 1 |
4 trials available for indomethacin and Hyperkalemia
| Article | Year |
|---|---|
Coadministration of estradiol/drospirenone and indomethacin does not cause hyperkalemia in healthy postmenopausal women: a randomized open-label crossover study.
Topics: Aged; Androstenes; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Drug Combinations; D | 2007 |
Indomethacin-induced azotaemia and hyperkalaemia: a case study.
Topics: Acute Disease; Aged; Clinical Trials as Topic; Female; Gout; Humans; Hyperkalemia; Indomethacin; Pot | 1981 |
Additive antiproteinuric effect of the NSAID indomethacin and the ACE inhibitor lisinopril.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Drug | 1990 |
Reduced incidence of hyperkalemia and azotemia in patients receiving sulindac compared with indomethacin.
Topics: Aged; Aged, 80 and over; Blood Urea Nitrogen; Female; Humans; Hyperkalemia; Indenes; Indomethacin; M | 1988 |
26 other studies available for indomethacin and Hyperkalemia
| Article | Year |
|---|---|
Hyperkalemia in the elderly.
Topics: Aged; Amiloride; Diagnosis, Differential; Electrolytes; Endocrine System Diseases; Female; Humans; H | 1984 |
Indomethacin-induced hyperkalemia and renal failure in multiple myeloma.
Topics: Acute Kidney Injury; Aged; Female; Humans; Hyperkalemia; Indomethacin; Kidney Function Tests; Male; | 1982 |
Indomethacin-associated hyperkalemia in the elderly.
Topics: Aged; Blood Urea Nitrogen; Creatinine; Female; Humans; Hyperkalemia; Indomethacin; Male; Middle Aged | 1983 |
Indomethacin- and Moduretic--induced hyperkalemia.
Topics: Aged; Amiloride; Diabetes Complications; Diabetes Mellitus; Drug Combinations; Drug Interactions; Fe | 1983 |
[Hyporeninemic hypoaldosteronism syndrome caused by indomethacin].
Topics: Adolescent; Adult; Aldosterone; Chronic Disease; Female; Glomerulonephritis; Humans; Hyperkalemia; I | 1980 |
Hyperkalemia associated with indomethacin.
Topics: Adult; Aldosterone; Arthritis, Infectious; Humans; Hyperkalemia; Indomethacin; Kidney; Male; Potassi | 1981 |
Reversible acute renal insufficiency and hyperkalemia following indomethacin therapy.
Topics: Acute Kidney Injury; Aged; Aldosterone; Depression, Chemical; Female; Gout; Humans; Hyperkalemia; In | 1981 |
Indomethacin-induced hyperkalemia in three patients with gouty arthritis.
Topics: Acute Disease; Acute Kidney Injury; Aged; Diabetes Mellitus; Female; Gout; Humans; Hyperkalemia; Ind | 1980 |
Effect of hydrochlorothiazide in pseudohypoaldosteronism with hypercalciuria and severe hyperkalemia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcium; Diuretics; Female; Furosemide; Humans; Hydrochloro | 1996 |
Hyperkalemia exposure impairs EDHF-mediated endothelial function in the human coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Biological Factors; Calcimycin; | 1997 |
Depolarizing cardiac arrest and endothelium-derived hyperpolarizing factor-mediated hyperpolarization and relaxation in coronary arteries: the effect and mechanism.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Biological Factors; Cor | 1997 |
Indomethacin-induced prostaglandin inhibition with hyperkalemia. A reversible cause of hyporeninemic hypoaldosteronism.
Topics: Adult; Aldosterone; Female; Glomerulonephritis; Humans; Hyperkalemia; Indomethacin; Potassium; Prost | 1979 |
Indomethacin-induced hyperkalaemia.
Topics: Humans; Hyperkalemia; Indomethacin; Kidney Failure, Chronic; Male; Middle Aged | 1979 |
Indomethacin-induced inhibition of prostaglandin with hyperkalemia.
Topics: Aged; Aldosterone; Female; Humans; Hyperkalemia; Indomethacin; Kidney Function Tests; Loop of Henle; | 1979 |
Indomethacin-induced inhibition of prostaglandin with hyperkalemia.
Topics: Aldosterone; Humans; Hyperkalemia; Ibuprofen; Indomethacin; Kidney; Male; Mineralocorticoid Receptor | 1979 |
[Conservative therapy of chronic glomerulonephritis].
Topics: Acidosis; Azathioprine; Chlorambucil; Chronic Disease; Chronic Kidney Disease-Mineral and Bone Disor | 1978 |
Short-term indomethacin administration does not impair excretion of acute potassium load in humans.
Topics: Administration, Oral; Adult; Female; Humans; Hyperkalemia; Indomethacin; Kidney; Kinetics; Male; Nat | 1992 |
Indomethacin does not impair cellular potassium uptake in the rat.
Topics: Animals; Cell Membrane Permeability; Hyperkalemia; Indomethacin; Kidney; Male; Nephrectomy; Potassiu | 1990 |
[Acute hyperkalemia and non-oliguric kidney failure during treatment with indomethacin, allopurinol, nifedipine, hydrochlorothiazide/amiloride, trimethoprim/sulfamethoxazole and acetylsalicylic acid].
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Allopurinol; Amiloride; Aspirin; Drug Combinations; Dr | 1988 |
Hyperkalemia induced by indomethacin and naproxen and reversed by fludrocortisone.
Topics: Fludrocortisone; Humans; Hyperkalemia; Indomethacin; Kidney; Male; Middle Aged; Naproxen | 1988 |
Therapeutic rounds. Nonsteroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Glomerular Filtration Rate; Humans; Hyperkalemia; Hyp | 1987 |
Acute renal failure and hyperkalemia associated with triamterene and indomethacin.
Topics: Acute Kidney Injury; Aged; Drug Interactions; Drug Therapy, Combination; Furosemide; Humans; Hyperka | 1986 |
Incidence of hyperkalaemia induced by indomethacin in a hospital population.
Topics: Aged; Humans; Hyperkalemia; Indomethacin; Middle Aged; Potassium; Prospective Studies | 1985 |
Incidence of hyperkalaemia induced by indomethacin.
Topics: Humans; Hyperkalemia; Indomethacin; Potassium | 1985 |
Nephrotoxicity from nonsteroidal anti-inflammatory drugs.
Topics: Acute Disease; Acute Kidney Injury; Aged; Anti-Inflammatory Agents; Aspirin; Female; Humans; Hyperka | 1985 |
Severe hyperkalemia caused by indomethacin and potassium supplementation.
Topics: Bartter Syndrome; Drug Therapy, Combination; Female; Humans; Hyperaldosteronism; Hyperkalemia; Indom | 1985 |