indomethacin has been researched along with Hypercholesterolemia in 20 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The tension of isolated rings was measured isometrically to compare the N(G)-nitro-L-arginine- and indomethacin-resistant relaxation by acetylcholine (ACh) in the renal artery from normal rabbits and short term hypercholesterolemia rabbits (0." | 7.71 | Short term hypercholesterolemia alters N(G)-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by acetylcholine in rabbit renal artery. ( Arai, K; Fujii, H; Honda, H; Kogo, H; Moroe, H; Notoya, Y, 2001) |
| "This study determines the antiplatelet effects of oral ticlopidine (100 mg/kg x day) in experimental hypercholesterolemia." | 7.69 | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. ( Braun, M; Hohlfeld, T; Scharnowski, F; Schrör, K, 1994) |
| "The aim of this study was to investigate the effect of hypercholesterolemia on the angiotensin II-induced contractions in the isolated aorta and iliac artery of the rabbit, with respect to the role of arachidonate metabolites." | 7.69 | Effects of hypercholesterolemia on the contractions to angiotensin II in the isolated aorta and iliac artery of the rabbit: role of arachidonic acid metabolites. ( Dam, JP; Porsius, AJ; Post, MJ; Riezebos, J; Vleeming, W; Wemer, J, 1997) |
| " We designed in vivo experiments to determine whether hypercholesterolemia with and without deficiency of two endogenous lipid antioxidants, vitamin E and selenium, would result in endothelial dysfunction." | 7.68 | Hypercholesterolemia promotes endothelial dysfunction in vitamin E- and selenium-deficient rats. ( Coffee, K; DeMaster, EG; Nagy, J; Raij, L, 1993) |
| "Bezafibrate was withdrawn and the patient became asymptomatic after seven days." | 6.38 | Bezafibrate induced rhabdomyolysis. ( Autonell, J; Brugués, J; Kanterewicz, E; Riba, J; Sanmartí, R; Trias, I, 1992) |
| "The tension of isolated rings was measured isometrically to compare the N(G)-nitro-L-arginine- and indomethacin-resistant relaxation by acetylcholine (ACh) in the renal artery from normal rabbits and short term hypercholesterolemia rabbits (0." | 3.71 | Short term hypercholesterolemia alters N(G)-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by acetylcholine in rabbit renal artery. ( Arai, K; Fujii, H; Honda, H; Kogo, H; Moroe, H; Notoya, Y, 2001) |
| "This study determines the antiplatelet effects of oral ticlopidine (100 mg/kg x day) in experimental hypercholesterolemia." | 3.69 | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. ( Braun, M; Hohlfeld, T; Scharnowski, F; Schrör, K, 1994) |
| "The aim of this study was to investigate the effect of hypercholesterolemia on the angiotensin II-induced contractions in the isolated aorta and iliac artery of the rabbit, with respect to the role of arachidonate metabolites." | 3.69 | Effects of hypercholesterolemia on the contractions to angiotensin II in the isolated aorta and iliac artery of the rabbit: role of arachidonic acid metabolites. ( Dam, JP; Porsius, AJ; Post, MJ; Riezebos, J; Vleeming, W; Wemer, J, 1997) |
| " We designed in vivo experiments to determine whether hypercholesterolemia with and without deficiency of two endogenous lipid antioxidants, vitamin E and selenium, would result in endothelial dysfunction." | 3.68 | Hypercholesterolemia promotes endothelial dysfunction in vitamin E- and selenium-deficient rats. ( Coffee, K; DeMaster, EG; Nagy, J; Raij, L, 1993) |
| "Late-onset sporadic Alzheimer's disease is a heterogeneous disorder." | 2.42 | Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. ( Casserly, I; Topol, E, 2004) |
| "Bezafibrate was withdrawn and the patient became asymptomatic after seven days." | 2.38 | Bezafibrate induced rhabdomyolysis. ( Autonell, J; Brugués, J; Kanterewicz, E; Riba, J; Sanmartí, R; Trias, I, 1992) |
| "Although long-term use of cyclooxygenase (COX)-2 inhibitors may be associated with increased cardiovascular risk, their effects on vascular reactivity in atherosclerosis has remained largely unexplored." | 1.35 | Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. ( Bäck, M; Brink, C; Foudi, N; Louedec, L; Michel, JB; Norel, X; Rienzo, M, 2009) |
| "Atherosclerosis is the most important single factor contributing to this disease burden." | 1.33 | Arterial endothelial function in a porcine model of early stage atherosclerotic vascular disease. ( Henderson, KK; Laughlin, MH; Turk, JR; Vanvickle, GD; Watkins, J, 2005) |
| "Full dose-response curves were constructed in 13 hypercholesterolemic and 12 normocholesterolemic subjects by infusing bradykinin (0." | 1.29 | Responsiveness to bradykinin in veins of hypercholesterolemic humans. ( Bedarida, GV; Blaschke, TF; Bushell, E; Haefeli, WE; Hoffman, BB, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Foudi, N | 1 |
| Norel, X | 1 |
| Rienzo, M | 1 |
| Louedec, L | 1 |
| Brink, C | 1 |
| Michel, JB | 1 |
| Bäck, M | 1 |
| Casserly, I | 1 |
| Topol, E | 1 |
| Moroe, H | 3 |
| Fujii, H | 2 |
| Honda, H | 4 |
| Arai, K | 2 |
| Kanazawa, M | 1 |
| Notoya, Y | 3 |
| Kogo, H | 2 |
| Taniguchi, J | 1 |
| Shibusawa, Y | 1 |
| Iwata, T | 1 |
| Turk, JR | 1 |
| Henderson, KK | 1 |
| Vanvickle, GD | 1 |
| Watkins, J | 1 |
| Laughlin, MH | 1 |
| Malakul, W | 1 |
| Thirawarapan, S | 1 |
| Suvitayavat, W | 1 |
| Woodman, OL | 1 |
| Hohlfeld, T | 1 |
| Scharnowski, F | 1 |
| Braun, M | 1 |
| Schrör, K | 1 |
| Bedarida, GV | 1 |
| Bushell, E | 1 |
| Haefeli, WE | 1 |
| Blaschke, TF | 1 |
| Hoffman, BB | 1 |
| Raij, L | 1 |
| Nagy, J | 1 |
| Coffee, K | 1 |
| DeMaster, EG | 1 |
| Pfister, SL | 1 |
| Campbell, WB | 1 |
| Dam, JP | 1 |
| Vleeming, W | 1 |
| Riezebos, J | 1 |
| Post, MJ | 1 |
| Porsius, AJ | 1 |
| Wemer, J | 1 |
| Brandes, RP | 1 |
| Behra, A | 1 |
| Lebherz, C | 1 |
| Böger, RH | 1 |
| Bode-Böger, SM | 1 |
| Phivthong-Ngam, L | 1 |
| Mügge, A | 1 |
| Azadzoi, KM | 2 |
| Krane, RJ | 1 |
| Saenz de Tejada, I | 2 |
| Goldstein, I | 1 |
| Siroky, MB | 1 |
| Ghanam, K | 1 |
| Lavagna, C | 1 |
| Burgaud, JL | 1 |
| Javellaud, J | 1 |
| Ea-Kim, L | 1 |
| Oudart, N | 1 |
| Kanterewicz, E | 1 |
| Sanmartí, R | 1 |
| Riba, J | 1 |
| Trias, I | 1 |
| Autonell, J | 1 |
| Brugués, J | 1 |
| Aviram, M | 1 |
| Winterstein, G | 1 |
| Brook, JG | 1 |
| Vihert, AM | 1 |
| Glezer, GA | 1 |
| Megrelishvili, RI | 1 |
| Ryff, IM | 1 |
2 reviews available for indomethacin and Hypercholesterolemia
| Article | Year |
|---|---|
Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Cholest | 2004 |
Bezafibrate induced rhabdomyolysis.
Topics: Aged; Bezafibrate; Female; Humans; Hypercholesterolemia; Hypertension; Indomethacin; Rhabdomyolysis | 1992 |
18 other studies available for indomethacin and Hypercholesterolemia
| Article | Year |
|---|---|
Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Cholester | 2009 |
Characterization of endothelium-dependent relaxation and modulation by treatment with pioglitazone in the hypercholesterolemic rabbit renal artery.
Topics: Animals; Biological Factors; Charybdotoxin; Endothelium, Vascular; Enzyme Inhibitors; Hypercholester | 2004 |
Alteration in endothelial function and modulation by treatment with pioglitazone in rabbit renal artery from short-term hypercholesterolemia.
Topics: Acetylcholine; Animals; Biological Factors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhib | 2005 |
Arterial endothelial function in a porcine model of early stage atherosclerotic vascular disease.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Atherosclerosis; Bradykinin; Carotid Artery, Common; Chole | 2005 |
Comparison of endothelial function in the carotid artery between normal and short-term hypercholesterolemic rabbits.
Topics: Acetylcholine; Animals; Biological Factors; Carotid Arteries; Cytochrome P-450 Enzyme Inhibitors; En | 2006 |
Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Biological Factors; Blood Glucose; Body Weight; Cha | 2008 |
Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia.
Topics: Adenosine Diphosphate; Animals; Aortic Diseases; Arteriosclerosis; Biotransformation; Cholesterol, D | 1994 |
Responsiveness to bradykinin in veins of hypercholesterolemic humans.
Topics: Adult; Aged; Aged, 80 and over; Bradykinin; Dose-Response Relationship, Drug; Drug Resistance; Endot | 1993 |
Hypercholesterolemia promotes endothelial dysfunction in vitamin E- and selenium-deficient rats.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Blood Pressure; Body Weight; Cholesterol; Dose-Respon | 1993 |
Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas.
Topics: Animals; Aorta; Arachidonic Acid; Cyclooxygenase Inhibitors; Hypercholesterolemia; Indomethacin; Lip | 1996 |
Effects of hypercholesterolemia on the contractions to angiotensin II in the isolated aorta and iliac artery of the rabbit: role of arachidonic acid metabolites.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Arachidonic Acid | 1997 |
N(G)-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation in the rabbit renal artery: effect of hypercholesterolemia.
Topics: Animals; Aorta, Thoracic; Cholesterol, Dietary; Dose-Response Relationship, Drug; Endothelium, Vascu | 1997 |
Relative roles of cyclooxygenase and nitric oxide synthase pathways in ischemia-induced increased contraction of cavernosal smooth muscle.
Topics: Animals; Arginine; Arteriosclerosis; Electric Stimulation; Enzyme Inhibitors; Hypercholesterolemia; | 1999 |
Involvement of cyclooxygenase 2 in the protective effect of 17beta-estradiol on hypercholesterolemic rabbit aorta.
Topics: Acetylcholine; Adenine; Animals; Aorta; Aspirin; Cholesterol; Cyclooxygenase 2; Cyclooxygenase 2 Inh | 2000 |
Short term hypercholesterolemia alters N(G)-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by acetylcholine in rabbit renal artery.
Topics: Acetylcholine; Animals; Endothelium, Vascular; Hypercholesterolemia; Indomethacin; Muscle Relaxation | 2001 |
Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle.
Topics: Acetylcholine; Animals; Cholesterol, Dietary; Dose-Response Relationship, Drug; Endothelium; Hyperch | 1991 |
Differential effect of platelet inhibitors in normal and in hypercholesterolaemic subjects.
Topics: Adult; Aspirin; Cyclic AMP; Dipyridamole; Epoprostenol; Humans; Hypercholesterolemia; In Vitro Techn | 1985 |
The use of indometacin for treating diffuse glomerulonephritis under experimental and clinical conditions.
Topics: Animals; Autoimmune Diseases; Blood Protein Disorders; Blood Proteins; Complement Fixation Tests; Dr | 1973 |