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indomethacin and Hypercholesterolemia

indomethacin has been researched along with Hypercholesterolemia in 20 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.

Research Excerpts

ExcerptRelevanceReference
"The tension of isolated rings was measured isometrically to compare the N(G)-nitro-L-arginine- and indomethacin-resistant relaxation by acetylcholine (ACh) in the renal artery from normal rabbits and short term hypercholesterolemia rabbits (0."7.71Short term hypercholesterolemia alters N(G)-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by acetylcholine in rabbit renal artery. ( Arai, K; Fujii, H; Honda, H; Kogo, H; Moroe, H; Notoya, Y, 2001)
"This study determines the antiplatelet effects of oral ticlopidine (100 mg/kg x day) in experimental hypercholesterolemia."7.69Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. ( Braun, M; Hohlfeld, T; Scharnowski, F; Schrör, K, 1994)
"The aim of this study was to investigate the effect of hypercholesterolemia on the angiotensin II-induced contractions in the isolated aorta and iliac artery of the rabbit, with respect to the role of arachidonate metabolites."7.69Effects of hypercholesterolemia on the contractions to angiotensin II in the isolated aorta and iliac artery of the rabbit: role of arachidonic acid metabolites. ( Dam, JP; Porsius, AJ; Post, MJ; Riezebos, J; Vleeming, W; Wemer, J, 1997)
" We designed in vivo experiments to determine whether hypercholesterolemia with and without deficiency of two endogenous lipid antioxidants, vitamin E and selenium, would result in endothelial dysfunction."7.68Hypercholesterolemia promotes endothelial dysfunction in vitamin E- and selenium-deficient rats. ( Coffee, K; DeMaster, EG; Nagy, J; Raij, L, 1993)
"Bezafibrate was withdrawn and the patient became asymptomatic after seven days."6.38Bezafibrate induced rhabdomyolysis. ( Autonell, J; Brugués, J; Kanterewicz, E; Riba, J; Sanmartí, R; Trias, I, 1992)
"The tension of isolated rings was measured isometrically to compare the N(G)-nitro-L-arginine- and indomethacin-resistant relaxation by acetylcholine (ACh) in the renal artery from normal rabbits and short term hypercholesterolemia rabbits (0."3.71Short term hypercholesterolemia alters N(G)-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by acetylcholine in rabbit renal artery. ( Arai, K; Fujii, H; Honda, H; Kogo, H; Moroe, H; Notoya, Y, 2001)
"This study determines the antiplatelet effects of oral ticlopidine (100 mg/kg x day) in experimental hypercholesterolemia."3.69Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. ( Braun, M; Hohlfeld, T; Scharnowski, F; Schrör, K, 1994)
"The aim of this study was to investigate the effect of hypercholesterolemia on the angiotensin II-induced contractions in the isolated aorta and iliac artery of the rabbit, with respect to the role of arachidonate metabolites."3.69Effects of hypercholesterolemia on the contractions to angiotensin II in the isolated aorta and iliac artery of the rabbit: role of arachidonic acid metabolites. ( Dam, JP; Porsius, AJ; Post, MJ; Riezebos, J; Vleeming, W; Wemer, J, 1997)
" We designed in vivo experiments to determine whether hypercholesterolemia with and without deficiency of two endogenous lipid antioxidants, vitamin E and selenium, would result in endothelial dysfunction."3.68Hypercholesterolemia promotes endothelial dysfunction in vitamin E- and selenium-deficient rats. ( Coffee, K; DeMaster, EG; Nagy, J; Raij, L, 1993)
"Late-onset sporadic Alzheimer's disease is a heterogeneous disorder."2.42Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins. ( Casserly, I; Topol, E, 2004)
"Bezafibrate was withdrawn and the patient became asymptomatic after seven days."2.38Bezafibrate induced rhabdomyolysis. ( Autonell, J; Brugués, J; Kanterewicz, E; Riba, J; Sanmartí, R; Trias, I, 1992)
"Although long-term use of cyclooxygenase (COX)-2 inhibitors may be associated with increased cardiovascular risk, their effects on vascular reactivity in atherosclerosis has remained largely unexplored."1.35Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. ( Bäck, M; Brink, C; Foudi, N; Louedec, L; Michel, JB; Norel, X; Rienzo, M, 2009)
"Atherosclerosis is the most important single factor contributing to this disease burden."1.33Arterial endothelial function in a porcine model of early stage atherosclerotic vascular disease. ( Henderson, KK; Laughlin, MH; Turk, JR; Vanvickle, GD; Watkins, J, 2005)
"Full dose-response curves were constructed in 13 hypercholesterolemic and 12 normocholesterolemic subjects by infusing bradykinin (0."1.29Responsiveness to bradykinin in veins of hypercholesterolemic humans. ( Bedarida, GV; Blaschke, TF; Bushell, E; Haefeli, WE; Hoffman, BB, 1993)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.00)18.7374
1990's9 (45.00)18.2507
2000's9 (45.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Foudi, N1
Norel, X1
Rienzo, M1
Louedec, L1
Brink, C1
Michel, JB1
Bäck, M1
Casserly, I1
Topol, E1
Moroe, H3
Fujii, H2
Honda, H4
Arai, K2
Kanazawa, M1
Notoya, Y3
Kogo, H2
Taniguchi, J1
Shibusawa, Y1
Iwata, T1
Turk, JR1
Henderson, KK1
Vanvickle, GD1
Watkins, J1
Laughlin, MH1
Malakul, W1
Thirawarapan, S1
Suvitayavat, W1
Woodman, OL1
Hohlfeld, T1
Scharnowski, F1
Braun, M1
Schrör, K1
Bedarida, GV1
Bushell, E1
Haefeli, WE1
Blaschke, TF1
Hoffman, BB1
Raij, L1
Nagy, J1
Coffee, K1
DeMaster, EG1
Pfister, SL1
Campbell, WB1
Dam, JP1
Vleeming, W1
Riezebos, J1
Post, MJ1
Porsius, AJ1
Wemer, J1
Brandes, RP1
Behra, A1
Lebherz, C1
Böger, RH1
Bode-Böger, SM1
Phivthong-Ngam, L1
Mügge, A1
Azadzoi, KM2
Krane, RJ1
Saenz de Tejada, I2
Goldstein, I1
Siroky, MB1
Ghanam, K1
Lavagna, C1
Burgaud, JL1
Javellaud, J1
Ea-Kim, L1
Oudart, N1
Kanterewicz, E1
Sanmartí, R1
Riba, J1
Trias, I1
Autonell, J1
Brugués, J1
Aviram, M1
Winterstein, G1
Brook, JG1
Vihert, AM1
Glezer, GA1
Megrelishvili, RI1
Ryff, IM1

Reviews

2 reviews available for indomethacin and Hypercholesterolemia

ArticleYear
Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, and misfolded proteins.
    Lancet (London, England), 2004, Apr-03, Volume: 363, Issue:9415

    Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Aspirin; Cholest

2004
Bezafibrate induced rhabdomyolysis.
    Annals of the rheumatic diseases, 1992, Volume: 51, Issue:4

    Topics: Aged; Bezafibrate; Female; Humans; Hypercholesterolemia; Hypertension; Indomethacin; Rhabdomyolysis

1992

Other Studies

18 other studies available for indomethacin and Hypercholesterolemia

ArticleYear
Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Cholester

2009
Characterization of endothelium-dependent relaxation and modulation by treatment with pioglitazone in the hypercholesterolemic rabbit renal artery.
    European journal of pharmacology, 2004, Aug-30, Volume: 497, Issue:3

    Topics: Animals; Biological Factors; Charybdotoxin; Endothelium, Vascular; Enzyme Inhibitors; Hypercholester

2004
Alteration in endothelial function and modulation by treatment with pioglitazone in rabbit renal artery from short-term hypercholesterolemia.
    Vascular pharmacology, 2005, Volume: 43, Issue:1

    Topics: Acetylcholine; Animals; Biological Factors; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhib

2005
Arterial endothelial function in a porcine model of early stage atherosclerotic vascular disease.
    International journal of experimental pathology, 2005, Volume: 86, Issue:5

    Topics: Acetylcholine; Animals; Aorta, Abdominal; Atherosclerosis; Bradykinin; Carotid Artery, Common; Chole

2005
Comparison of endothelial function in the carotid artery between normal and short-term hypercholesterolemic rabbits.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2006, Volume: 144, Issue:2

    Topics: Acetylcholine; Animals; Biological Factors; Carotid Arteries; Cytochrome P-450 Enzyme Inhibitors; En

2006
Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:2

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Biological Factors; Blood Glucose; Body Weight; Cha

2008
Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia.
    Thrombosis and haemostasis, 1994, Volume: 71, Issue:1

    Topics: Adenosine Diphosphate; Animals; Aortic Diseases; Arteriosclerosis; Biotransformation; Cholesterol, D

1994
Responsiveness to bradykinin in veins of hypercholesterolemic humans.
    Circulation, 1993, Volume: 88, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Bradykinin; Dose-Response Relationship, Drug; Drug Resistance; Endot

1993
Hypercholesterolemia promotes endothelial dysfunction in vitamin E- and selenium-deficient rats.
    Hypertension (Dallas, Tex. : 1979), 1993, Volume: 22, Issue:1

    Topics: Acetylcholine; Adenosine Diphosphate; Animals; Blood Pressure; Body Weight; Cholesterol; Dose-Respon

1993
Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:6

    Topics: Animals; Aorta; Arachidonic Acid; Cyclooxygenase Inhibitors; Hypercholesterolemia; Indomethacin; Lip

1996
Effects of hypercholesterolemia on the contractions to angiotensin II in the isolated aorta and iliac artery of the rabbit: role of arachidonic acid metabolites.
    Journal of cardiovascular pharmacology, 1997, Volume: 30, Issue:1

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Arachidonic Acid

1997
N(G)-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation in the rabbit renal artery: effect of hypercholesterolemia.
    Atherosclerosis, 1997, Volume: 135, Issue:1

    Topics: Animals; Aorta, Thoracic; Cholesterol, Dietary; Dose-Response Relationship, Drug; Endothelium, Vascu

1997
Relative roles of cyclooxygenase and nitric oxide synthase pathways in ischemia-induced increased contraction of cavernosal smooth muscle.
    The Journal of urology, 1999, Volume: 161, Issue:4

    Topics: Animals; Arginine; Arteriosclerosis; Electric Stimulation; Enzyme Inhibitors; Hypercholesterolemia;

1999
Involvement of cyclooxygenase 2 in the protective effect of 17beta-estradiol on hypercholesterolemic rabbit aorta.
    Biochemical and biophysical research communications, 2000, Aug-28, Volume: 275, Issue:2

    Topics: Acetylcholine; Adenine; Animals; Aorta; Aspirin; Cholesterol; Cyclooxygenase 2; Cyclooxygenase 2 Inh

2000
Short term hypercholesterolemia alters N(G)-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by acetylcholine in rabbit renal artery.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:2

    Topics: Acetylcholine; Animals; Endothelium, Vascular; Hypercholesterolemia; Indomethacin; Muscle Relaxation

2001
Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle.
    The Journal of urology, 1991, Volume: 146, Issue:1

    Topics: Acetylcholine; Animals; Cholesterol, Dietary; Dose-Response Relationship, Drug; Endothelium; Hyperch

1991
Differential effect of platelet inhibitors in normal and in hypercholesterolaemic subjects.
    British journal of clinical pharmacology, 1985, Volume: 19, Issue:6

    Topics: Adult; Aspirin; Cyclic AMP; Dipyridamole; Epoprostenol; Humans; Hypercholesterolemia; In Vitro Techn

1985
The use of indometacin for treating diffuse glomerulonephritis under experimental and clinical conditions.
    Arzneimittel-Forschung, 1973, Volume: 23, Issue:7

    Topics: Animals; Autoimmune Diseases; Blood Protein Disorders; Blood Proteins; Complement Fixation Tests; Dr

1973