indomethacin has been researched along with Hypercapnia in 57 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
Excerpt | Relevance | Reference |
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"We investigated the effect of moderate (FiO2 13%) and light hypoxia (FiO2 17%) and hypercapnia (CO2 2-4%) with or without indomethacin on circulating levels of endothelin/endothelins (ET) and cerebral blood flow (CBF) in healthy volunteers." | 9.07 | Endothelin-1 and cerebral blood flow: influence of hypoxia, hypercapnia and indomethacin on circulating endothelin levels in healthy volunteers. ( Bünemann, L; Bøgeskov Nielsen, L; Freundlich, M; Jensen, KA; Therkelsen, K; Thorshauge, H, 1994) |
"To investigate using an arterial spin tagging (AST) approach the effect of indomethacin on the cerebral blood flow (CBF) response to hypercapnia." | 7.71 | Effects of indomethacin on cerebral blood flow at rest and during hypercapnia: an arterial spin tagging study in humans. ( Frank, JA; Lewis, BK; McLaughlin, AC; St Lawrence, KS; Weinberger, DR; Ye, FQ, 2002) |
" We therefore investigated the effect of indomethacin on the CBF increase caused by acetazolamide (Az), a drug that induces brain extracellular acidosis, which triggers its effect on CBF." | 7.68 | Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia? ( Lassen, NA; Paulson, OB; Wang, Q, 1993) |
"Responses of pial arterioles to topically applied arachidonic acid, conversion of exogenous arachidonic acid to prostanoids, and pial arteriolar dilation to hypercapnia were examined before and at progressive times after treatment with indomethacin (5 mg/kg i." | 7.68 | Effects of indomethacin on cerebral vasodilator responses to arachidonic acid and hypercapnia in newborn pigs. ( Armstead, WM; Leffler, CW; Mirro, R; Parfenova, H; Shibata, M; Zuckerman, S, 1993) |
"To study the contribution of prostaglandins to cerebral vasodilatation during hypercapnia, we inhibited prostaglandin synthesis with indomethacin." | 7.66 | Effects of indomethacin on cerebral blood flow during hypercapnia in cats. ( Busija, DW; Heistad, DD, 1983) |
"We investigated the effect of moderate (FiO2 13%) and light hypoxia (FiO2 17%) and hypercapnia (CO2 2-4%) with or without indomethacin on circulating levels of endothelin/endothelins (ET) and cerebral blood flow (CBF) in healthy volunteers." | 5.07 | Endothelin-1 and cerebral blood flow: influence of hypoxia, hypercapnia and indomethacin on circulating endothelin levels in healthy volunteers. ( Bünemann, L; Bøgeskov Nielsen, L; Freundlich, M; Jensen, KA; Therkelsen, K; Thorshauge, H, 1994) |
" MCA velocity (MCAv) was measured at baseline and during stepped hypercapnia (2%, 4%, and 6% FiCO2) before and after cyclooxygenase inhibition using indomethacin." | 3.79 | Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults. ( Barnes, JN; Johnson, CP; Joyner, MJ; Kluck, BN; Taylor, JL, 2013) |
" Corticocerebral blood flow was measured by hydrogen polarography during hypercapnia and acetazolamide stimuli in conscious rabbits." | 3.71 | Influence of nitrovasodilators and cyclooxygenase inhibitors on cerebral vasoreactivity in conscious rabbits. ( Barzó, P; Bodosi, M; Csete, K; Papp, JG, 2001) |
" We therefore investigated the effect of indomethacin on the CBF increase caused by acetazolamide (Az), a drug that induces brain extracellular acidosis, which triggers its effect on CBF." | 3.68 | Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia? ( Lassen, NA; Paulson, OB; Wang, Q, 1993) |
"Responses of pial arterioles to topically applied arachidonic acid, conversion of exogenous arachidonic acid to prostanoids, and pial arteriolar dilation to hypercapnia were examined before and at progressive times after treatment with indomethacin (5 mg/kg i." | 3.68 | Effects of indomethacin on cerebral vasodilator responses to arachidonic acid and hypercapnia in newborn pigs. ( Armstead, WM; Leffler, CW; Mirro, R; Parfenova, H; Shibata, M; Zuckerman, S, 1993) |
" Diameter of one pial arteriole was determined during baseline conditions and topical application of 10(-5) M phorbol 12, 13-dibutyrate (PDB) and during subsequent application of one of the following: arterial hypercapnia (inhalation of 10% CO2), topical application of cerebrospinal fluid with 12 mM K+, or topical application of 10(-5) M isoproterenol in cerebrospinal fluid." | 3.68 | Reversal by increased CSF [H+] and [K+] of phorbol ester-induced arteriolar constriction in piglets. ( Busija, DW; Chen, J, 1992) |
"Using awake, chronically catheterized newborn pigs, we measured cerebral blood flow (CBF), net cerebral vascular 6-keto-prostaglandin F1 alpha production, and cerebral metabolic rate of oxygen (CMRO2) during hypercapnia and during hypercapnia at increased mean airway pressure (Paw), both before and after treatment with indomethacin." | 3.68 | Pressure ventilation increases brain vascular prostacyclin production in newborn pigs. ( Armstead, WM; Busija, DW; Leffler, CW; Mirro, R, 1990) |
"The effect of cyclooxygenase inhibition by indomethacin on regional cerebral blood flow (CBF) during hypocapnia induced by hyperventilation and during hypercapnia induced by CO2 inhalation was examined." | 3.67 | Effect of indomethacin on the regulation of cerebral blood flow during respiratory alkalosis in newborn piglets. ( DeGiulio, PA; Delivoria-Papadopoulos, M; Mishra, OP; Roth, RA; Wagerle, LC, 1989) |
"Cerebral blood flow (CBF) was measured in conscious rats treated with indomethacin, diclofenac or the vehicle for indomethacin during hypercapnia of three different degrees." | 3.67 | Effects of indomethacin and diclofenac on cerebral blood flow in hypercapnic conscious rats. ( Quintana, A; Quintana, MA; Raczka, E, 1988) |
"Although results obtained in baboons and rats have demonstrated that the fatty acid cyclo-oxygenase inhibitor indomethacin reduces cerebral blood flow (CBF) under control conditions and markedly attenuates the CBF response to hypercapnia, nonconfirmatory results have been obtained in rabbits and cats." | 3.66 | Effects of indomethacin on cerebral blood flow and oxygen consumption in barbiturate-anesthetized Normocapnic and hypercapnic rats. ( Dahlgren, N; Siesjö, BK, 1981) |
" The inhibition of prostaglandin synthesis with indomethacin or aspirin blocks the vasodilatatory effect of hypercapnia and, to a lesser extent, of hypoxia." | 3.66 | [The metabolic regulation of the retinal blood flow and the role of prostaglandins (author's transl)]. ( Pournaras, C; Tsacopoulos, M, 1978) |
"To further our understanding of central sleep apnea (CSA) at high altitude during acclimatization, we tested the hypothesis that pharmacologically altering cerebral blood flow (CBF) would alter the severity of CSA at high altitude." | 2.79 | Influence of cerebral blood flow on central sleep apnea at high altitude. ( Ainslie, PN; Basnyat, R; Burgess, KR; Dawson, A; Donnelly, J; Lucas, RA; Lucas, SJ; Peebles, KC; Shepherd, K; Swart, M; Thomas, KN, 2014) |
"The functional hemodynamic parameter mean flow velocity (MFV) was assessed at rest, before and 90min after 100mg of INDO, and during the BHT." | 2.78 | Effect of indomethacin on cerebrovascular reactivity in patients with type 2 diabetes mellitus. ( Demarin, V; Drenjancevic, I; Rahelic, D; Vuletic, V, 2013) |
"Indomethacin (INDO) has the potential to be a useful tool to explore the influence of cerebral blood flow and its responses to CO(2) on ventilatory control." | 2.76 | Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to hypoxia. ( Ainslie, PN; Burgess, KR; Cotter, JD; Fan, JL; Lucas, RA; Lucas, SJ; Peebles, KC; Thomas, KN, 2011) |
"Indomethacin (IND) is a non-steroidal anti-inflammatory agent with unique effects on cerebral blood flow physiology which may be of benefit in reducing elevated ICP in TBI patients." | 2.40 | Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients. ( Rhoney, DH; Slavik, RS, 1999) |
"Indomethacin (IMC) was used as cyclooxygenase inhibitor." | 1.31 | Cyclooxygenase-pathway participates in the regulation of regional cerebral blood flow in response to neuronal activation under normo- and hypercapnia. ( Bakalova, RA; Kanno, I; Matsuura, T, 2002) |
" We hypothesized that with chronic administration of indomethacin the piglet would advance the role of the NO system in cerebrovascular responses." | 1.31 | Chronic administration of indomethacin increases role of nitric oxide in hypercapnic cerebrovasodilation in piglets. ( Son, M; Zuckerman, S, 2002) |
"Ibuprofen treatment (30 mg/kg) had no effect on pial arteriolar diameter during normoxia or hypoxia, and pretreatment did not alter dilation to hypoxia." | 1.30 | Cerebral arteriolar dilation to hypoxia: role of prostanoids. ( Leffler, CW; Parfenova, H, 1997) |
"Since chronic hypertension has been associated with impaired endothelial function, we designed a study to find out whether hypercapnic cerebral blood flow and its nitric oxide- and prostaglandin-sensitive component is reduced in spontaneously hypertensive rats (SHR) compared with normotensive controls." | 1.30 | Hypercapnic cerebral blood flow in spontaneously hypertensive rats. ( Casadei, B; Heinert, G; Paterson, DJ, 1998) |
"We studied the effect of systemic hypoxemia and hypercarbia on the bronchial blood flow in open-chested, anesthetized dogs." | 1.27 | Hypoxia and hypercarbia increase bronchial blood flow through bronchopulmonary anastomoses in anesthetized dogs. ( Albert, RK; Butler, J; Charan, NB; Kirk, W; Lakshminarayan, S, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 20 (35.09) | 18.7374 |
1990's | 18 (31.58) | 18.2507 |
2000's | 11 (19.30) | 29.6817 |
2010's | 8 (14.04) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Barnes, JN | 2 |
Taylor, JL | 1 |
Kluck, BN | 1 |
Johnson, CP | 1 |
Joyner, MJ | 3 |
Vuletic, V | 1 |
Drenjancevic, I | 1 |
Rahelic, D | 1 |
Demarin, V | 1 |
Harrell, JW | 1 |
Schrage, WG | 1 |
Burgess, KR | 2 |
Lucas, SJ | 2 |
Shepherd, K | 1 |
Dawson, A | 1 |
Swart, M | 1 |
Thomas, KN | 2 |
Lucas, RA | 2 |
Donnelly, J | 1 |
Peebles, KC | 2 |
Basnyat, R | 1 |
Ainslie, PN | 3 |
Beaudin, AE | 1 |
Waltz, X | 1 |
Pun, M | 1 |
Wynne-Edwards, KE | 1 |
Ahmed, SB | 1 |
Anderson, TJ | 1 |
Hanly, PJ | 1 |
Poulin, MJ | 1 |
Hoiland, RL | 1 |
Tymko, MM | 1 |
Bain, AR | 1 |
Wildfong, KW | 1 |
Monteleone, B | 1 |
Xie, A | 1 |
Skatrud, JB | 1 |
Barczi, SR | 1 |
Reichmuth, K | 1 |
Morgan, BJ | 1 |
Mont, S | 1 |
Dempsey, JA | 1 |
Ivancev, V | 1 |
Bakovic, D | 1 |
Obad, A | 1 |
Breskovic, T | 1 |
Palada, I | 1 |
Dujic, Z | 1 |
Lenti, L | 1 |
Zimmermann, A | 1 |
Kis, D | 1 |
Oláh, O | 1 |
Tóth, GK | 1 |
Hegyi, O | 1 |
Busija, DW | 8 |
Bari, F | 2 |
Domoki, F | 2 |
Fan, JL | 1 |
Cotter, JD | 1 |
Schmidt, JE | 1 |
Nicholson, WT | 1 |
St Lawrence, KS | 1 |
Ye, FQ | 1 |
Lewis, BK | 1 |
Weinberger, DR | 1 |
Frank, JA | 1 |
McLaughlin, AC | 1 |
Bakalova, RA | 1 |
Matsuura, T | 1 |
Kanno, I | 1 |
Nagy, K | 1 |
Temesvári, P | 1 |
Siesjö, BK | 4 |
Nilsson, B | 1 |
Heistad, DD | 1 |
Jackson, EK | 1 |
Gerkens, JF | 1 |
Zimmerman, JB | 1 |
Uderman, HD | 1 |
Oates, JA | 1 |
Workman, RJ | 1 |
Branch, RA | 1 |
Gabrielian, ES | 2 |
Amroian, EA | 2 |
Hoffman, WE | 1 |
Albrecht, RF | 1 |
Pelligrino, D | 1 |
Miletich, DJ | 1 |
Dahlgren, N | 1 |
Wei, EP | 1 |
Ellis, EF | 1 |
Kontos, HA | 1 |
Parfenova, H | 4 |
Shibata, M | 5 |
Zuckerman, S | 4 |
Leffler, CW | 12 |
Mirro, R | 3 |
Pharris, LJ | 1 |
Therkelsen, K | 1 |
Jensen, KA | 1 |
Freundlich, M | 1 |
Thorshauge, H | 1 |
Bünemann, L | 1 |
Bøgeskov Nielsen, L | 1 |
Wang, Q | 1 |
Paulson, OB | 1 |
Lassen, NA | 1 |
Armstead, WM | 3 |
Hsu, P | 2 |
Nilsson, F | 1 |
Björkman, S | 1 |
Rosén, I | 1 |
Messeter, K | 1 |
Nordström, CH | 1 |
Zuckerman, SL | 1 |
Rudinsky, BF | 1 |
Lozon, M | 1 |
Bell, A | 1 |
Hipps, R | 1 |
Meadow, WL | 1 |
Yamaguchi, K | 1 |
Suzuki, K | 1 |
Naoki, K | 1 |
Nishio, K | 1 |
Sato, N | 1 |
Takeshita, K | 1 |
Kudo, H | 1 |
Aoki, T | 1 |
Suzuki, Y | 1 |
Miyata, A | 1 |
Tsumura, H | 1 |
Okazaki, K | 1 |
Endou, M | 1 |
Okumura, F | 1 |
Heinert, G | 1 |
Casadei, B | 1 |
Paterson, DJ | 1 |
Slavik, RS | 1 |
Rhoney, DH | 1 |
Stark, AR | 1 |
Carlo, WA | 1 |
Tyson, JE | 1 |
Papile, LA | 1 |
Wright, LL | 1 |
Shankaran, S | 1 |
Donovan, EF | 1 |
Oh, W | 1 |
Bauer, CR | 1 |
Saha, S | 1 |
Poole, WK | 1 |
Stoll, BJ | 1 |
Csete, K | 1 |
Barzó, P | 1 |
Bodosi, M | 1 |
Papp, JG | 1 |
Willis, AP | 1 |
Son, M | 1 |
Zhang, Y | 1 |
Megrabian, VI | 1 |
Sakabe, T | 1 |
Pournaras, C | 2 |
Tsacopoulos, M | 2 |
Chapuis, P | 1 |
Chen, J | 1 |
Norins, NA | 1 |
Wendelberger, K | 1 |
Hoffman, RG | 1 |
Keller, PA | 1 |
Madden, JA | 1 |
DeGiulio, PA | 1 |
Roth, RA | 1 |
Mishra, OP | 1 |
Delivoria-Papadopoulos, M | 1 |
Wagerle, LC | 1 |
Quintana, A | 1 |
Raczka, E | 1 |
Quintana, MA | 1 |
Charan, NB | 1 |
Lakshminarayan, S | 1 |
Albert, RK | 1 |
Kirk, W | 1 |
Butler, J | 1 |
Fletcher, AM | 1 |
Beasley, DG | 1 |
Hessler, JR | 1 |
Green, RS | 1 |
Pickard, JD | 1 |
Mackenzie, ET | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise[NCT03722953] | 18 participants (Actual) | Interventional | 2018-12-01 | Completed | |||
Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults[NCT05131217] | 13 participants (Actual) | Interventional | 2022-01-14 | Completed | |||
MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans[NCT02729428] | 71 participants (Actual) | Observational | 2016-04-30 | Completed | |||
Cerebral Vasodilator Responses in Sedentary and Exercise Trained Humans[NCT02653638] | Early Phase 1 | 80 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
Brain Blood Flow Response to Hypercapnia in Healthy Adults: The Effect of Age and Sex[NCT02840851] | 46 participants (Actual) | Observational | 2016-11-30 | Completed | |||
Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness[NCT04586049] | 70 participants (Anticipated) | Observational | 2023-05-16 | Recruiting | |||
The Impact of Cerebral Anatomical Variations on Cerebrovascular Reactivity[NCT05396287] | 80 participants (Anticipated) | Observational | 2022-07-19 | Enrolling by invitation | |||
Cerebrovascular Outcomes in Ischemic Heart Disease Patients Undergoing Cardiac Rehabilitation[NCT02715661] | 140 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
Randomized Trial of Minimal Ventilator Support and Early Corticosteroid Therapy to Increase Survival Without Chronic Lung Disease in Extremely-Low-Birth-Weight Infants[NCT00005777] | Phase 3 | 220 participants (Actual) | Interventional | 1998-02-28 | Terminated (stopped due to The trial was halted because of unanticipated nonrespiratory adverse events related to dexamethasone therapy.) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 reviews available for indomethacin and Hypercapnia
Article | Year |
---|---|
Prostaglandins and the cerebral circulation.
Topics: Animals; Brain; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Dose-Response Relationship, | 1982 |
Cerebral metabolic rate in hypercarbia--a controversy.
Topics: Amino Acids; Animals; Brain; Carbon Dioxide; Cerebrovascular Circulation; Citric Acid Cycle; Diazepa | 1980 |
Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients.
Topics: Adult; Animals; Barbiturates; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Cerebrovascular | 1999 |
9 trials available for indomethacin and Hypercapnia
Article | Year |
---|---|
Effect of indomethacin on cerebrovascular reactivity in patients with type 2 diabetes mellitus.
Topics: Adolescent; Adult; Aged; Brain; Cardiovascular Agents; Cerebrovascular Circulation; Diabetes Mellitu | 2013 |
Cyclooxygenase-derived vasoconstriction restrains hypoxia-mediated cerebral vasodilation in young adults with metabolic syndrome.
Topics: Adult; Blood Flow Velocity; Carbon Dioxide; Cyclooxygenase Inhibitors; Double-Blind Method; Female; | 2014 |
Influence of cerebral blood flow on central sleep apnea at high altitude.
Topics: Acclimatization; Acetazolamide; Administration, Intravenous; Administration, Oral; Adult; Altitude; | 2014 |
Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cross-Over Studies; Double-Blind Method; | 2015 |
Carbon dioxide-mediated vasomotion of extra-cranial cerebral arteries in humans: a role for prostaglandins?
Topics: Adolescent; Adult; Carbon Dioxide; Carotid Artery, Internal; Cerebrovascular Circulation; Cyclooxyge | 2016 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiovascular Agents; Cerebrovascular Circulation; Cros | 2009 |
Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to hypoxia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cerebrovascular Circulation; Female; Humans; | 2011 |
Endothelin-1 and cerebral blood flow: influence of hypoxia, hypercapnia and indomethacin on circulating endothelin levels in healthy volunteers.
Topics: Adolescent; Adult; Cerebrovascular Circulation; Double-Blind Method; Endothelins; Female; Humans; Hy | 1994 |
Adverse effects of early dexamethasone treatment in extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dexamethasone; D | 2001 |
45 other studies available for indomethacin and Hypercapnia
Article | Year |
---|---|
Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults.
Topics: Adult; Age Factors; Arterial Pressure; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat | 2013 |
Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults.
Topics: Adult; Age Factors; Arterial Pressure; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat | 2013 |
Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults.
Topics: Adult; Age Factors; Arterial Pressure; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat | 2013 |
Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults.
Topics: Adult; Age Factors; Arterial Pressure; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat | 2013 |
Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults.
Topics: Adult; Age Factors; Arterial Pressure; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat | 2013 |
Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults.
Topics: Adult; Age Factors; Arterial Pressure; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat | 2013 |
Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults.
Topics: Adult; Age Factors; Arterial Pressure; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat | 2013 |
Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults.
Topics: Adult; Age Factors; Arterial Pressure; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat | 2013 |
Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults.
Topics: Adult; Age Factors; Arterial Pressure; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat | 2013 |
Influence of cerebral blood flow on breathing stability.
Topics: Adolescent; Adult; Blood Flow Velocity; Brain; Carbon Dioxide; Cardiovascular Agents; Cerebrovascula | 2009 |
PACAP and VIP differentially preserve neurovascular reactivity after global cerebral ischemia in newborn pigs.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Arterioles; Brain Ischemia; Cere | 2009 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia.
Topics: Adolescent; Adult; Aged; Aging; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Female; Huma | 2012 |
Effects of indomethacin on cerebral blood flow at rest and during hypercapnia: an arterial spin tagging study in humans.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Brain; Cerebrovascular Circulation; | 2002 |
Cyclooxygenase-pathway participates in the regulation of regional cerebral blood flow in response to neuronal activation under normo- and hypercapnia.
Topics: Acid-Base Equilibrium; Animals; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Cerebral Cortex | 2002 |
Selective inhibitors differentially affect cyclooxygenase-dependent pial arteriolar responses in newborn pigs.
Topics: Acetaminophen; Animals; Animals, Newborn; Arterioles; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge | 2005 |
Effects of indomethacin on cerebral blood flow during hypercapnia in cats.
Topics: Animals; Blood Pressure; Brain; Carbon Dioxide; Cats; Cerebrovascular Circulation; Hypercapnia; Indo | 1983 |
Role of prostaglandins in the response of the cerebral circulation to carbon dioxide in conscious rabbits.
Topics: Animals; Carbon Dioxide; Cerebrovascular Circulation; Consciousness; Hypercapnia; Indomethacin; Micr | 1983 |
Prostaglandin biosynthesis does not participate in hypercapnia-induced cerebral vasodilatation in the dog.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Cerebrovascular Circulation; Dogs; Epo | 1983 |
[Effect of CO2 on thrombocyte aggregation in the cat].
Topics: Animals; Cats; Cyclooxygenase Inhibitors; Hypercapnia; Indomethacin; Platelet Aggregation | 1984 |
Effects of prostaglandins on the cerebral circulation in the coat.
Topics: Animals; Cerebrovascular Circulation; Dinoprost; Dinoprostone; Epoprostenol; Female; Goats; Hypercap | 1982 |
Effects of indomethacin on cerebral blood flow and oxygen consumption in barbiturate-anesthetized Normocapnic and hypercapnic rats.
Topics: Anesthetics; Animals; Brain; Cerebrovascular Circulation; Hypercapnia; Indomethacin; Nitrous Oxide; | 1981 |
Role of prostaglandins in pial arteriolar response to CO2 and hypoxia.
Topics: Animals; Arterioles; Benzene Derivatives; Carbon Dioxide; Cats; Hypercapnia; Hypoxia; Indomethacin; | 1980 |
CO2 and cerebral circulation in newborn pigs: cyclic nucleotides and prostanoids in vascular regulation.
Topics: Amino Acid Oxidoreductases; Animals; Animals, Newborn; Arterioles; Blood Vessels; Carbon Dioxide; Ce | 1994 |
Permissive role of prostacyclin in cerebral vasodilation to hypercapnia in newborn pigs.
Topics: Animals; Animals, Newborn; Cerebrovascular Circulation; Dinoprostone; Epoprostenol; Hypercapnia; Ilo | 1994 |
Inhibitory effect of indomethacin on prostacyclin receptor-mediated cerebral vascular responses.
Topics: Animals; Animals, Newborn; Arterioles; Aspirin; Cerebrovascular Circulation; Hypercapnia; Iloprost; | 1995 |
Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia?
Topics: Acetazolamide; Acidosis; Animals; Carbon Dioxide; Cerebrovascular Circulation; Diclofenac; Extracell | 1993 |
Effects of indomethacin on cerebral vasodilator responses to arachidonic acid and hypercapnia in newborn pigs.
Topics: Animals; Animals, Newborn; Arachidonic Acid; Arterioles; Cerebrovascular Circulation; Dinoprost; Din | 1993 |
Prostanoid synthesis in response to high CO2 in newborn pig brain microvascular endothelial cells.
Topics: Animals; Animals, Newborn; Calcimycin; Carbon Dioxide; Cells, Cultured; Cerebrovascular Circulation; | 1993 |
Cerebral vasoconstriction by indomethacin in intracranial hypertension. An experimental investigation in pigs.
Topics: Animals; Cerebrovascular Circulation; Hypercapnia; Indomethacin; Intracranial Pressure; Swine; Vascu | 1995 |
Age dependence of cerebrovascular response mechanisms in domestic pigs.
Topics: Acetylcholine; Aging; Animals; Animals, Newborn; Arterioles; Cerebrovascular Circulation; Cyclooxyge | 1996 |
Group B streptococcal sepsis impairs cerebral vascular reactivity to acute hypercarbia in piglets.
Topics: Animals; Blood Pressure; Brain; Carbon Monoxide; Carotid Artery, Internal; Disease Models, Animal; H | 1996 |
Cerebral arteriolar dilation to hypoxia: role of prostanoids.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Arterioles; Cerebrovascular Circulation; Hy | 1997 |
Response of intra-acinar pulmonary microvessels to hypoxia, hypercapnic acidosis, and isocapnic acidosis.
Topics: 6-Ketoprostaglandin F1 alpha; Acidosis; Animals; Arterioles; Capillaries; Carbon Dioxide; Epoprosten | 1998 |
Involvement of barium-sensitive K+ channels in endothelium-dependent vasodilation produced by hypercapnia in rat mesenteric vascular beds.
Topics: Animals; Barium; Bicarbonates; Carbon Dioxide; Cytochrome P-450 Enzyme Inhibitors; Endothelium; Hydr | 1998 |
Hypercapnic cerebral blood flow in spontaneously hypertensive rats.
Topics: Animals; Blood Flow Velocity; Cerebral Cortex; Cerebrovascular Circulation; Enzyme Inhibitors; Hyper | 1998 |
Influence of nitrovasodilators and cyclooxygenase inhibitors on cerebral vasoreactivity in conscious rabbits.
Topics: Acetazolamide; Animals; Blood Pressure; Blood Vessels; Cerebrovascular Circulation; Cyclooxygenase I | 2001 |
Endothelial NO and prostanoid involvement in newborn and juvenile pig pial arteriolar vasomotor responses.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Age Factors; Animals; Animals, Newborn; Arterioles; Bra | 2001 |
Chronic administration of indomethacin increases role of nitric oxide in hypercapnic cerebrovasodilation in piglets.
Topics: Administration, Topical; Animals; Animals, Newborn; Blood Pressure; Brain; Cyclooxygenase Inhibitors | 2002 |
Compensatory role of NO in cerebral circulation of piglets chronically treated with indomethacin.
Topics: Acetylcholine; Animals; Animals, Newborn; Bradykinin; Cardiovascular Agents; Cells, Cultured; Cerebr | 2002 |
[Cerebral blood flow reactions to hypo- and hypercapnia during indomethacin inhibition of prostaglandin biosynthesis].
Topics: Acid-Base Equilibrium; Animals; Carbon Dioxide; Cats; Cerebrospinal Fluid; Cerebrovascular Circulati | 1979 |
The effect of indomethacin on the blood flow-metabolism couple in the brain under normal, hypercapnic and hypoxic conditions.
Topics: Animals; Brain; Cerebrovascular Circulation; Hypercapnia; Hypoxia; Indomethacin; Male; Oxygen; Parti | 1979 |
[The metabolic regulation of the retinal blood flow and the role of prostaglandins (author's transl)].
Topics: Animals; Arterioles; Aspirin; Histamine; Hypercapnia; Hypoxia; Indomethacin; Prostaglandins E; Regio | 1978 |
Studies on the role of prostaglandins in the regulation of retinal blood flow.
Topics: Animals; Arterioles; Aspirin; Fluorescein Angiography; Hypercapnia; Hypoxia; Indomethacin; Prostagla | 1978 |
Reversal by increased CSF [H+] and [K+] of phorbol ester-induced arteriolar constriction in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Colforsin; Hydrogen; Hypercapnia; Indomethacin; Isoproterenol | 1992 |
Effects of indomethacin on myogenic contractile activation and responses to changes in O2 and CO2 in isolated feline cerebral arteries.
Topics: Animals; Carbon Dioxide; Cats; Cerebral Arteries; Female; Hypercapnia; Hypoxia; In Vitro Techniques; | 1992 |
Pressure ventilation increases brain vascular prostacyclin production in newborn pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Brain; Cerebrovascular Circulation; Epopros | 1990 |
Effect of indomethacin on the regulation of cerebral blood flow during respiratory alkalosis in newborn piglets.
Topics: Alkalosis, Respiratory; Animals; Animals, Newborn; Carbon Dioxide; Cerebrovascular Circulation; Elec | 1989 |
Effects of indomethacin and diclofenac on cerebral blood flow in hypercapnic conscious rats.
Topics: Animals; Carbon Dioxide; Cerebrovascular Circulation; Diclofenac; Hypercapnia; Indomethacin; Male; R | 1988 |
Hypoxia and hypercarbia increase bronchial blood flow through bronchopulmonary anastomoses in anesthetized dogs.
Topics: Anesthesia, General; Animals; Arteriovenous Anastomosis; Bronchi; Bronchial Arteries; Dogs; Hypercap | 1986 |
Indomethacin does not potentiate renovascular constriction during hypercapnia in unanesthetized rabbits.
Topics: Animals; Cyclooxygenase Inhibitors; Hypercapnia; Indomethacin; Kidney; Prostaglandins; Rabbits; Regi | 1985 |
Prostanoids in cortical subarachnoid cerebrospinal fluid and pial arterial diameter in newborn pigs.
Topics: Animals; Animals, Newborn; Cerebral Arteries; Cisterna Magna; Female; Hypercapnia; Hypoxia, Brain; I | 1985 |
Effects of indomethacin upon cerebral hemodynamics of newborn pigs.
Topics: Animals; Animals, Newborn; Blood-Brain Barrier; Cerebrovascular Circulation; Hemodynamics; Hypercapn | 1985 |
Inhibition of prostaglandin synthesis and the response of baboon cerebral circulation to carbon dioxide.
Topics: Animals; Brain; Cerebrovascular Circulation; Haplorhini; Hypercapnia; Indomethacin; Papio; Prostagla | 1973 |