Page last updated: 2024-10-29

indomethacin and Hypercalcemia

indomethacin has been researched along with Hypercalcemia in 70 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Hypercalcemia: Abnormally high level of calcium in the blood.

Research Excerpts

ExcerptRelevanceReference
"An infant presented with a non-metastatic renal spindle cell sarcoma and hypercalcaemia, which resolved after treatment with indomethacin."7.68Indomethacin responsive hypercalcaemia associated with a renal sarcoma. ( Dillon, MJ; Gibbs, J; Lang, S; Meghji, S; Pritchard, J, 1990)
" We therefore assessed the effect of Indomethacin and aspirin on some parameters of calcium metabolism in patients with breast cancer."7.65Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. ( Bondy, PK; Coombes, RC; Neville, AM; Powles, TJ, 1976)
"Recombinant human TGF alpha-induced bone resorption was completely inhibited by indomethacin."5.29Ascites sarcoma 180, a tumor associated with hypercalcemia, secretes potent bone-resorbing factors including transforming growth factor alpha, interleukin-1 alpha and interleukin-6. ( Suzuki, K; Yamada, S, 1994)
"Hypercalcemia is a known complication of childhood malignancies but has never been reported to be associated with Langerhans cell histiocytosis (LCH) in a pediatric patient."5.29Langerhans cell histiocytosis and hypercalcemia: clinical response to indomethacin. ( McLean, TW; Pritchard, J, 1996)
"The hypercalcemia was unresponsive to hydration and oral phosphate."5.25Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. ( Alexander, RW; Brereton, HD; DeVita, VT; Halushka, PV; Keiser, HR; Mason, DM, 1974)
" Less convincing, but suggestive evidence exists for: 1-asparaginase, iatrogenic hypercalcemia, chlorthalidine, corticosteroids, ethacrynic acid, phenformin, and procainamide."4.76Drug-induced pancreatitis: a critical review. ( Kern, F; Mallory, A, 1980)
"The hypothesis that endogenous PGE2 mediates defective thick ascending limb (TAL) Cl reabsorption (percent delivered load: FRCl%) in rats with vitamin D-induced chronic hypercalcemia (HC) was tested by measuring FRCl% in loop segments microperfused in vivo in HC and control rats treated acutely with indomethacin (Indo) or its vehicle, and obtaining the corresponding outer medullary [PGE2]."3.68Endogenous prostaglandin E2 mediates inhibition of rat thick ascending limb Cl reabsorption in chronic hypercalcemia. ( Borzecki, JS; McKay, AJ; Peterson, LN, 1993)
"An infant presented with a non-metastatic renal spindle cell sarcoma and hypercalcaemia, which resolved after treatment with indomethacin."3.68Indomethacin responsive hypercalcaemia associated with a renal sarcoma. ( Dillon, MJ; Gibbs, J; Lang, S; Meghji, S; Pritchard, J, 1990)
" We therefore assessed the effect of Indomethacin and aspirin on some parameters of calcium metabolism in patients with breast cancer."3.65Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. ( Bondy, PK; Coombes, RC; Neville, AM; Powles, TJ, 1976)
"Indomethacin was effective in only one of five patients to whom it was given, and EHDP was effective also in only one of five patients."2.65Comparative study of available medical therapy for hypercalcemia of malignancy. ( Heath, DA; Mundy, GR; Wilkinson, R, 1983)
"Recombinant human TGF alpha-induced bone resorption was completely inhibited by indomethacin."1.29Ascites sarcoma 180, a tumor associated with hypercalcemia, secretes potent bone-resorbing factors including transforming growth factor alpha, interleukin-1 alpha and interleukin-6. ( Suzuki, K; Yamada, S, 1994)
"Hypercalcemia is a known complication of childhood malignancies but has never been reported to be associated with Langerhans cell histiocytosis (LCH) in a pediatric patient."1.29Langerhans cell histiocytosis and hypercalcemia: clinical response to indomethacin. ( McLean, TW; Pritchard, J, 1996)
"Human pancreatic cancer cells (FA-6) producing bone resorbing factor were established in culture."1.28The tumor cells (FA-6) established from a pancreatic cancer associated with humoral hypercalcemia of malignancy: a simultaneous production of parathyroid hormone-like activity and transforming growth factor activity. ( Akatsu, T; Kinoshita, T; Kosano, H; Kugai, N; Nagata, N; Shimauchi, T; Takatani, O; Ueyama, Y; Yasutomo, Y, 1989)
"Treatment with prednisolone (1."1.27Association of hypercalcemia with tumors producing colony-stimulating factor(s). ( Asano, S; Kondo, Y; Kosaka, K; Mori, M; Ohkawa, H; Ohsawa, N; Okabe, T; Sato, K; Sato, N; Ueyama, Y, 1983)
"By an autopsy, hepatocellular carcinoma was found in the right lobe of the liver."1.27Prostaglandin-E-producing hepatocellular carcinoma with hypercalcemia. ( Hasumura, Y; Ikeda, T; Takeuchi, J; Tozuka, S, 1988)
"Therefore, 146 trials of treatment for hypercalcemia between 1980 and 1983 at the National Cancer Center Hospital, Tokyo, were evaluated retrospectively."1.27A retrospective evaluation of the medical treatment of malignancy-associated hypercalcemia. ( Abe, K; Adachi, I; Kimura, S; Matsubara, H; Sato, Y; Suemasu, K; Suzuki, M; Yamaguchi, K, 1986)
"Hypercalcemia is associated with impaired urinary concentrating ability."1.27Role of the loop segment in the urinary concentrating defect of hypercalcemia. ( Booker, BB; Galla, JH; Luke, RG, 1986)
"Indomethacin was given to four patients with hypercalcemia with no effect on serum calcium levels in any cases."1.27Hypercalcemia of cancer in the digestive tract. ( Furuta, S; Monno, S; Nagata, A, 1987)
"Patients with advanced breast cancer may develop acute, severe hypercalcemia when treated with estrogens or antiestrogens."1.27Estrogens and antiestrogens stimulate release of bone resorbing activity by cultured human breast cancer cells. ( Eilon, G; Mundy, GR; Saez, S; Valentin-Opran, A, 1985)
"Tumor-stimulated bone resorption was blocked by indomethacin and eicosatetraynoic acid, inhibitors of the synthesis of prostaglandins (PGs) and related metabolites of arachidonic acid, whereas resorption stimulated by parathyroid hormone (PTH), PGE2, or 1,25-(OH)2D3 was not."1.26Bone resorption and humoral hypercalcemia of malignancy: stimulation of bone resorption in vitro by tumor extracts is inhibited by prostaglandin synthesis inhibitors. ( Fredericks, RS; Minkin, C; Pokress, S; Rude, RK; Sharp, CF; Singer, FR; Tong, M, 1981)
"Treatment with indomethacin, a potent inhibitor of prostaglandin synthesis, did not lower serum calcium concentrations with two different doses (1·6 mg/kg/day orally and 5 mg/kg/day i."1.26Prostaglandin E production and hypercalcaemia in rats bearing the Walker carcinosarcoma. ( Bonsch, G; Erlenmaier, T; Imbeck, H; Minne, HW; Mrongovius, R; Müller, H; Seyberth, HW; Strein, K, 1980)
"The treatment of hypercalcemia is directed toward immediate correction of the electrolyte imbalance and long-term control."1.26Genitourinary malignancy and pseudohyperparathyroidism. ( Barry, JM; Carey, TC; Metcalfe, JB, 1978)
"Indomethacin treatment lowered both serum calcium and the plasma level of 15-keto-13,14-dihydro-PGE2."1.26Prostaglandin-mediated hypercalcemia in the VX2 carcinoma-bearing rabbit. ( Hubbard, WC; Oates, JA; Oelz, O; Seyberth, HW; Sweetman, BJ; Watson, JT, 1977)
"The production of bone resorption-stimulating activity and PGE2 by VX2 cells in culture were both inhibited by indomethacin (100 ng/ml)."1.25Hypercalcemia and tumor-prostaglandins: the VX2 carcinoma model in the rabbit. ( Franklin, R; Levine, L; Tashjian, AH; Voelkel, EF; Wasserman, E, 1975)
"The specific bone resorption-stimulating activity of the HSDM(1) factor extracted from the tumor is high and approximately equal to that of PGE(2) as measured in a bone tissue culture system in vitro."1.25Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer. ( Goldhaber, P; Levine, L; Tashjian, AH; Voelkel, EF, 1972)
"The hypercalcemia was unresponsive to hydration and oral phosphate."1.25Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma. ( Alexander, RW; Brereton, HD; DeVita, VT; Halushka, PV; Keiser, HR; Mason, DM, 1974)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-199063 (90.00)18.7374
1990's5 (7.14)18.2507
2000's1 (1.43)29.6817
2010's1 (1.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pacifici, GM1
Diament, MJ1
Peluffo, GD1
Stillitani, I1
Cerchietti, LC1
Navigante, A1
Ranuncolo, SM1
Klein, SM1
Doppelt, SH1
Slovik, DM1
Neer, RM1
Nolan, J1
Zusman, RM1
Potts, JT3
Mundy, GR3
Wilkinson, R1
Heath, DA1
Gennari, C1
Montagnani, M1
Nami, R1
Francini, G1
Elliott, GT1
McKenzie, MW1
Levi, M2
Ellis, MA1
Berl, T2
Kukreja, SC1
Schürer, CC1
Peters, U1
Fischer, JT1
Peterson, L1
Kondo, Y2
Sato, K4
Ohkawa, H2
Ueyama, Y3
Okabe, T2
Sato, N1
Asano, S1
Mori, M1
Ohsawa, N2
Kosaka, K1
Ritchie, GA1
Heath, H2
Weller, RE1
Minkin, C1
Fredericks, RS1
Pokress, S1
Rude, RK1
Sharp, CF1
Tong, M1
Singer, FR1
Serros, ER1
Kirschenbaum, MA1
Takeuchi, T1
Takeuchi, H1
Hoshino, R1
Ohmi, K1
Mallory, A1
Kern, F1
Brenner, DE1
Harvey, HA1
Lipton, A1
Demers, L1
Josse, RG1
Wilson, DR1
Heersche, JN1
Mills, JR1
Murray, TM1
Seyberth, HW5
Bonsch, G1
Müller, H1
Minne, HW1
Erlenmaier, T1
Strein, K1
Imbeck, H1
Mrongovius, R1
Suzuki, K1
Yamada, S1
Lozance, LA1
Zafirovska, KG1
Bogdanovska, SV1
Zafirovski, GJ1
Peterson, LN1
McKay, AJ1
Borzecki, JS1
McLean, TW1
Pritchard, J2
Blum, I1
Dindogru, A1
Gailani, S1
Henderson, ES1
Wallace, HJ1
Fitzpatrick, J1
Benvenisti, D1
Goldberg, H1
Sturtridge, WC1
Segre, GV3
Hamet, P1
Sweetman, BJ3
Oates, JA4
Jaffe, BM2
Kopen, DF1
DeSchryver-Kecskemeti, K1
Gingerich, RL1
Greider, M1
Godeau, P1
Wechsler, B1
Lambrozo, J1
Raisz, LG1
Morita, R1
Metcalfe, JB1
Carey, TC1
Barry, JM1
Pina Boronat, R1
Buzón Rueda, JL1
Arenas Mirave, JI1
Boixeda Miquel, D1
Hernández Ranz, F1
Moreira Vicente, V1
Rodríguez San Pedro, F1
Gaskin, KJ1
Vines, RH1
Tashjian, AH6
Voelkel, EF5
Levine, L5
Hubbard, WC1
Oelz, O1
Watson, JT1
Robertson, RP2
Baylink, DJ2
Metz, SA1
Cummings, KB1
Coombes, RC1
Neville, AM2
Bondy, PK1
Powles, TJ2
Franklin, R1
Wasserman, E1
Marini, BJ1
Adkison, HW1
Ito, H1
Sanada, T1
Katayama, T1
Shimazaki, J1
Morgan, JL1
Gibbs, J1
Dillon, MJ1
Lang, S1
Meghji, S1
Chasan, SA1
Pothel, LR1
Huben, RP1
Nagata, N1
Akatsu, T1
Kugai, N1
Yasutomo, Y1
Kinoshita, T1
Kosano, H1
Shimauchi, T1
Takatani, O1
Ikeda, T1
Tozuka, S1
Hasumura, Y1
Takeuchi, J1
Kimura, S2
Sato, Y1
Matsubara, H1
Adachi, I1
Yamaguchi, K1
Suzuki, M1
Suemasu, K1
Abe, K1
Bringhurst, FR1
Bierer, BE1
Godeau, F1
Neyhard, N1
Varner, V1
Fujii, Y2
Kasono, K1
Tsushima, T2
Shizume, K2
Mimura, H1
Han, DC1
Kakiuchi, T1
Galla, JH1
Booker, BB1
Luke, RG1
Ono, M1
Nomura, H1
Monno, S1
Nagata, A1
Furuta, S1
Masa Jiménez, JF1
Verea Hernando, H1
Montero Martínez, C1
Fontán Bueso, JM1
Gavras, I1
Hatinoglou, S1
Benetos, A1
Gavras, H1
Valentin-Opran, A1
Eilon, G1
Saez, S1
Law, WM1
Uchida, T1
Kuwao, S1
Ishibashi, A1
Koshiba, K1
Goldhaber, P3
Clark, SA1
Easty, DM1
Easty, GC1
Brereton, HD1
Halushka, PV1
Alexander, RW1
Mason, DM1
Keiser, HR1
DeVita, VT1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I Pilot Trial to Study the Safety and Efficacy of Concomitant Radiotherapy and Zoledronic Acid for the Palliation of Bone Metastases From Breast Cancer, Prostate Cancer and Lung Cancer[NCT00264420]Phase 14 participants (Actual)Interventional2005-12-31Completed
A Pilot Study of Immunoregulatory Factor Expression and Immune Responses in Patients With Squamous Cell Carcinoma or Papilloma of the Upper Aerodigestive Tract[NCT00001603]93 participants Observational1996-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for indomethacin and Hypercalcemia

ArticleYear
Clinical pharmacology of the loop diuretics furosemide and bumetanide in neonates and infants.
    Paediatric drugs, 2012, Aug-01, Volume: 14, Issue:4

    Topics: Acetazolamide; Bumetanide; Drug Therapy, Combination; Ductus Arteriosus, Patent; Extracorporeal Memb

2012
Treatment of hypercalcemia.
    Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:1

    Topics: Calcium; Chelating Agents; Diuresis; Diuretics; Female; Humans; Hypercalcemia; Indomethacin; Male; M

1983
Drug-induced pancreatitis: a critical review.
    Gastroenterology, 1980, Volume: 78, Issue:4

    Topics: Acetaminophen; Adrenal Cortex Hormones; Amphetamines; Asparaginase; Azathioprine; Chlorthalidone; Ch

1980
Prostaglandins and hypercalcemic states.
    Annual review of medicine, 1978, Volume: 29

    Topics: Adenocarcinoma; Animals; Bone and Bones; Bone Resorption; Humans; Hypercalcemia; Indomethacin; Kidne

1978
Prostaglandins and cancer: an update.
    Prostaglandins, 1974, Jun-25, Volume: 6, Issue:6

    Topics: Animals; Aspirin; Bucladesine; Calcium; Carcinoma; Cell Division; Cell Line; Depression, Chemical; H

1974

Trials

1 trial available for indomethacin and Hypercalcemia

ArticleYear
Comparative study of available medical therapy for hypercalcemia of malignancy.
    The American journal of medicine, 1983, Volume: 74, Issue:3

    Topics: Administration, Oral; Adult; Aged; Calcium; Clinical Trials as Topic; Diphosphonates; Etidronic Acid

1983

Other Studies

64 other studies available for indomethacin and Hypercalcemia

ArticleYear
Inhibition of tumor progression and paraneoplastic syndrome development in a murine lung adenocarcinoma by medroxyprogesterone acetate and indomethacin.
    Cancer investigation, 2006, Volume: 24, Issue:2

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Hormonal; A

2006
Gut-mediated hypercalcemia in rabbits bearing VX2 carcinoma: new mechanism for tumor-induced hypercalcemia.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:2

    Topics: Animals; Carcinoma; Clodronic Acid; Hypercalcemia; Indomethacin; Male; Neoplasms, Experimental; Pros

1982
[Humoral mechanisms in neoplastic hypercalcemia].
    Minerva medica, 1984, Feb-18, Volume: 75, Issue:6

    Topics: Calcitonin; Calcium; Cyclic AMP; Humans; Hypercalcemia; Indomethacin; Neoplasms; Parathyroid Hormone

1984
Control of renal hemodynamics and glomerular filtration rate in chronic hypercalcemia. Role of prostaglandins, renin-angiotensin system, and calcium.
    The Journal of clinical investigation, 1983, Volume: 71, Issue:6

    Topics: Angiotensin II; Animals; Calcium; Captopril; Glomerular Filtration Rate; Hemodynamics; Hypercalcemia

1983
Diagnosis and management of hypercalcemia.
    Comprehensive therapy, 1980, Volume: 6, Issue:8

    Topics: Calcitonin; Glucocorticoids; Humans; Hypercalcemia; Hyperparathyroidism; Indomethacin; Neoplasms; Ph

1980
[Hypercalcemia in non-parathyroid malignant tumors].
    Minerva medica, 1981, May-19, Volume: 72, Issue:20

    Topics: Adrenal Cortex Hormones; Bone Neoplasms; Diuretics; Humans; Hypercalcemia; Indomethacin; Neoplasms;

1981
[Therapeutic possibilities in paraneoplastic hypercalcemia].
    Die Medizinische Welt, 1981, Aug-14, Volume: 32, Issue:32-33

    Topics: Adrenal Cortex Hormones; Adult; Aged; Calcitonin; Diphosphonates; Drug Therapy, Combination; Female;

1981
Mechanism of concentrating defect in hypercalcemia. Role of polydipsia and prostaglandins.
    Kidney international, 1983, Volume: 23, Issue:3

    Topics: Animals; Body Water; Dinoprostone; Drinking; Glomerular Filtration Rate; Hypercalcemia; Indomethacin

1983
Association of hypercalcemia with tumors producing colony-stimulating factor(s).
    Cancer research, 1983, Volume: 43, Issue:5

    Topics: Adult; Animals; Calcium; Carcinoma, Squamous Cell; Colony-Stimulating Factors; Female; Granulocytes;

1983
The direct inhibition of prostaglandin synthetase of human breast cancer tumor tissue by tamoxifen.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 71

    Topics: Bone Neoplasms; Bone Resorption; Breast Neoplasms; Cyclooxygenase Inhibitors; Dose-Response Relation

1980
Canine lymphosarcoma: a model for study of the hypercalcemia of cancer.
    Calcified tissue international, 1980, Volume: 30, Issue:2

    Topics: Animals; Antineoplastic Agents; Aspirin; Bone Resorption; Calcium; Disease Models, Animal; Dog Disea

1980
Bone resorption and humoral hypercalcemia of malignancy: stimulation of bone resorption in vitro by tumor extracts is inhibited by prostaglandin synthesis inhibitors.
    The Journal of clinical endocrinology and metabolism, 1981, Volume: 53, Issue:5

    Topics: Adult; Animals; Arachidonic Acid; Arachidonic Acids; Biological Assay; Bone and Bones; Bone Resorpti

1981
Prostaglandin-dependent polyuria in hypercalcemia.
    The American journal of physiology, 1981, Volume: 241, Issue:3

    Topics: Animals; Calcitriol; Female; Hypercalcemia; Indomethacin; Kidney; Polyuria; Prostaglandins; Prostagl

1981
Rhabdomyosarcoma-induced hypercalcemia in a nude mouse.
    Cancer, 1982, Jul-01, Volume: 50, Issue:1

    Topics: Animals; Anus Neoplasms; Calcium; Dinoprostone; Female; Humans; Hypercalcemia; Indomethacin; Mice; M

1982
A study of prostaglandin E2, parathormone, and response to indomethacin in patients with hypercalcemia of malignancy.
    Cancer, 1982, Feb-01, Volume: 49, Issue:3

    Topics: Humans; Hypercalcemia; Indomethacin; Neoplasms; Parathyroid Hormone; Prospective Studies; Prostaglan

1982
Hypercalcemia with ovarian carcinoma: evidence of a pathogenetic role for prostaglandins.
    Cancer, 1981, Sep-01, Volume: 48, Issue:5

    Topics: Aged; Animals; Biological Assay; Bone Resorption; Cystadenocarcinoma; Female; Humans; Hypercalcemia;

1981
Prostaglandin E production and hypercalcaemia in rats bearing the Walker carcinosarcoma.
    British journal of cancer, 1980, Volume: 42, Issue:3

    Topics: Animals; Calcium; Carcinoma 256, Walker; Dexamethasone; Female; Hypercalcemia; Indomethacin; Parathy

1980
Ascites sarcoma 180, a tumor associated with hypercalcemia, secretes potent bone-resorbing factors including transforming growth factor alpha, interleukin-1 alpha and interleukin-6.
    Bone and mineral, 1994, Volume: 27, Issue:3

    Topics: Animals; Antibodies; Blotting, Northern; Bone Resorption; Culture Media, Conditioned; Cyclic AMP; Di

1994
Primary disseminated form of Ewing sarcoma in association with hypercalcemia and acute renal failure.
    Renal failure, 1994, Volume: 16, Issue:4

    Topics: Acute Kidney Injury; Adult; Glomerular Filtration Rate; Humans; Hypercalcemia; Hyperparathyroidism,

1994
Endogenous prostaglandin E2 mediates inhibition of rat thick ascending limb Cl reabsorption in chronic hypercalcemia.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:6

    Topics: Alkaloids; Animals; Biological Transport, Active; Chlorides; Chronic Disease; Colforsin; Cyclic AMP;

1993
Langerhans cell histiocytosis and hypercalcemia: clinical response to indomethacin.
    Journal of pediatric hematology/oncology, 1996, Volume: 18, Issue:3

    Topics: Cyclooxygenase Inhibitors; Fatal Outcome; Follow-Up Studies; Histiocytosis, Langerhans-Cell; Humans;

1996
Letter: Indomethacin in hypercalcaemia.
    Lancet (London, England), 1975, Apr-12, Volume: 1, Issue:7911

    Topics: Administration, Oral; Calcium; Humans; Hypercalcemia; Indomethacin; Time Factors

1975
Letter: Indomethacin in hypercalcaemia.
    Lancet (London, England), 1975, Aug-23, Volume: 2, Issue:7930

    Topics: Adenocarcinoma; Calcium; Humans; Hypercalcemia; Indomethacin; Kidney Neoplasms; Multiple Myeloma

1975
Letter: Prostaglandins, indomethacin and hypercalcemia in neoplastic disease.
    The New England journal of medicine, 1975, May-29, Volume: 292, Issue:22

    Topics: Aged; Carcinoma, Squamous Cell; Humans; Hypercalcemia; Indomethacin; Liver Neoplasms; Lung Neoplasms

1975
Pharmacology and therapeutics of bone.
    Journal of dental research, 1975, Volume: 54 Spec No B

    Topics: Animals; Bone Resorption; Calcitonin; Calcium; Cyclic AMP; Endotoxins; Glucocorticoids; Humans; Hydr

1975
Characterization of the group of patients with the hypercalcemia of cancer who respond to treatment with prostaglandin synthesis inhibitors.
    Transactions of the Association of American Physicians, 1976, Volume: 89

    Topics: Aspirin; Calcium; Cyclic AMP; Humans; Hypercalcemia; Hyperparathyroidism; Indomethacin; Neoplasm Met

1976
Indomethacin-responsive pancreatic cholera.
    The New England journal of medicine, 1977, Oct-13, Volume: 297, Issue:15

    Topics: Adenoma, Islet Cell; Aged; Dehydration; Diarrhea; Female; Gastrins; Humans; Hypercalcemia; Hypokalem

1977
[Treatment of hypercalcemia].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1977, Jun-23, Volume: 53, Issue:24

    Topics: Calcitonin; Furosemide; Humans; Hypercalcemia; Indomethacin; Peritoneal Dialysis; Phosphates; Plicam

1977
[Indomethacin loading test].
    Nihon rinsho. Japanese journal of clinical medicine, 1979, Jun-29, Volume: Suppl

    Topics: Calcium; Humans; Hypercalcemia; Indomethacin; Neoplasms; Prostaglandins

1979
Genitourinary malignancy and pseudohyperparathyroidism.
    The Journal of urology, 1978, Volume: 119, Issue:5

    Topics: Carcinoma, Squamous Cell; Castration; Dysgerminoma; Female; Furosemide; Humans; Hypercalcemia; Hyper

1978
[Response to the administration of indomethacin in a case of paraneoplastic hypercalcemia].
    Revista clinica espanola, 1977, Oct-31, Volume: 147, Issue:2

    Topics: Aged; Carcinoma, Squamous Cell; Dexamethasone; Drug Evaluation; Humans; Hypercalcemia; Indomethacin;

1977
Hypercalcaemia: an unusual complication of tuberculosis. A case report.
    Australian paediatric journal, 1978, Volume: 14, Issue:1

    Topics: Child; Humans; Hypercalcemia; Indomethacin; Male; Tuberculosis, Lymph Node

1978
Plasma concentrations of 13,14-dihydro-15-keto-prostaglandin E2 in rabbits bearing the VX2 carcinoma: effects of hydrocortisone and indomethacin.
    Prostaglandins, 1977, Volume: 14, Issue:2

    Topics: Animals; Calcium; Hydrocortisone; Hypercalcemia; Indomethacin; Neoplasms, Experimental; Prostaglandi

1977
Prostaglandin-mediated hypercalcemia in the VX2 carcinoma-bearing rabbit.
    Prostaglandins, 1977, Volume: 14, Issue:2

    Topics: Animals; Arachidonic Acids; Blood Urea Nitrogen; Creatinine; Hypercalcemia; Indomethacin; Liver; Lun

1977
Plasma prostaglandin E in patients with cancer with and without hypercalcemia.
    The Journal of clinical endocrinology and metabolism, 1976, Volume: 43, Issue:6

    Topics: Bone Neoplasms; Female; Humans; Hypercalcemia; Indomethacin; Male; Neoplasm Metastasis; Neoplasms; P

1976
Failure of indomethacin to reduce hypercalcemia in patients with breast cancer.
    Prostaglandins, 1976, Volume: 12, Issue:6

    Topics: Aspirin; Bone Neoplasms; Breast Neoplasms; Calcium; Creatinine; Female; Humans; Hydroxyproline; Hype

1976
Hypercalcemia and tumor-prostaglandins: the VX2 carcinoma model in the rabbit.
    Metabolism: clinical and experimental, 1975, Volume: 24, Issue:8

    Topics: Animals; Biological Assay; Bone Resorption; Carcinoma; Disease Models, Animal; Femoral Vein; Hyperca

1975
Elevated prostaglandins and suppressed parathyroid hormone associated with hypercalcemia and renal cell carcinoma.
    The Journal of clinical endocrinology and metabolism, 1975, Volume: 41, Issue:1

    Topics: Adenocarcinoma; Calcium; Humans; Hypercalcemia; Indomethacin; Kidney Cortex; Liver; Liver Neoplasms;

1975
Letter: Indomethacin-responsive hypercalcemia.
    The New England journal of medicine, 1975, 09-11, Volume: 293, Issue:11

    Topics: Adenocarcinoma; Humans; Hypercalcemia; Indomethacin; Kidney Neoplasms; Male; Middle Aged

1975
Prostaglandins as mediators of hypercalcemia associated with certain types of cancer.
    The New England journal of medicine, 1975, Dec-18, Volume: 293, Issue:25

    Topics: Aspirin; Calcium; Humans; Hypercalcemia; Indomethacin; Male; Middle Aged; Neoplasms; Parathyroid Hor

1975
Editorial: Prostaglandins, hypercalcemia and cancer.
    The New England journal of medicine, 1975, Dec-18, Volume: 293, Issue:25

    Topics: Animals; Aspirin; Humans; Hypercalcemia; Indomethacin; Mice; Neoplasms; Prostaglandin Antagonists; P

1975
Indomethacin responsive hypercalcaemia associated with a renal sarcoma.
    Archives of disease in childhood, 1990, Volume: 65, Issue:10

    Topics: Combined Modality Therapy; Dinoprostone; Humans; Hypercalcemia; Indomethacin; Infant; Kidney Neoplas

1990
Management and prognostic significance of hypercalcemia in renal cell carcinoma.
    Urology, 1989, Volume: 33, Issue:3

    Topics: Calcitonin; Calcium; Carcinoma, Renal Cell; Furosemide; Humans; Hypercalcemia; Indomethacin; Kidney

1989
The tumor cells (FA-6) established from a pancreatic cancer associated with humoral hypercalcemia of malignancy: a simultaneous production of parathyroid hormone-like activity and transforming growth factor activity.
    Endocrinologia japonica, 1989, Volume: 36, Issue:1

    Topics: Animals; Biological Assay; Bone and Bones; Bone Resorption; Chromatography, Gel; Culture Media; Cycl

1989
Prostaglandin-E-producing hepatocellular carcinoma with hypercalcemia.
    Cancer, 1988, May-01, Volume: 61, Issue:9

    Topics: Aged; Carcinoma, Hepatocellular; Humans; Hypercalcemia; Indomethacin; Liver Neoplasms; Male; Phospha

1988
[Hypercalcemia].
    Gan no rinsho. Japan journal of cancer clinics, 1989, Volume: Spec No

    Topics: Calcitonin; Humans; Hypercalcemia; Indomethacin; Paraneoplastic Syndromes; Prednisolone

1989
A retrospective evaluation of the medical treatment of malignancy-associated hypercalcemia.
    Japanese journal of cancer research : Gann, 1986, Volume: 77, Issue:1

    Topics: Adult; Aged; Calcitonin; Calcium; Female; Fluid Therapy; Glucocorticoids; Humans; Hypercalcemia; Ind

1986
Humoral hypercalcemia of malignancy. Release of a prostaglandin-stimulating bone-resorbing factor in vitro by human transitional-cell carcinoma cells.
    The Journal of clinical investigation, 1986, Volume: 77, Issue:2

    Topics: Animals; Biological Assay; Biological Products; Bone Resorption; Calcitonin; Carcinoma, Transitional

1986
Production of interleukin-1 alpha and a parathyroid hormone-like factor by a squamous cell carcinoma of the esophagus (EC-GI) derived from a patient with hypercalcemia.
    The Journal of clinical endocrinology and metabolism, 1988, Volume: 67, Issue:3

    Topics: Aged; Animals; Bone Resorption; Carcinoma, Squamous Cell; Chromatography; DNA; Esophageal Neoplasms;

1988
Production of bone-resorbing activity and colony-stimulating activity in vivo and in vitro by a human squamous cell carcinoma associated with hypercalcemia and leukocytosis.
    The Journal of clinical investigation, 1986, Volume: 78, Issue:1

    Topics: Animals; Bone Resorption; Carcinoma, Squamous Cell; Chromatography, Gel; Colony-Stimulating Factors;

1986
Role of the loop segment in the urinary concentrating defect of hypercalcemia.
    Kidney international, 1986, Volume: 29, Issue:5

    Topics: Animals; Biological Transport, Active; Calcium; Calcium Gluconate; Chlorides; Ergocalciferols; Hyper

1986
Production of interleukin 1 alpha-like factor and colony-stimulating factor by a squamous cell carcinoma of the thyroid (T3M-5) derived from a patient with hypercalcemia and leukocytosis.
    Cancer research, 1987, Dec-15, Volume: 47, Issue:24 Pt 1

    Topics: Aged; Bone Resorption; Carcinoma, Squamous Cell; Chromatography, Ion Exchange; Colony-Stimulating Fa

1987
Hypercalcemia of cancer in the digestive tract.
    Journal of clinical gastroenterology, 1987, Volume: 9, Issue:1

    Topics: Aged; Aged, 80 and over; Bone Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Hypercalcemia;

1987
[Indomethacin treatment of hypercalcemia associated with pulmonary adenocarcinoma].
    Revista clinica espanola, 1986, Volume: 178, Issue:2

    Topics: Humans; Hypercalcemia; Indomethacin; Lung Neoplasms; Male; Middle Aged

1986
Calcium stimulates vasopressin release.
    Journal of hypertension, 1986, Volume: 4, Issue:4

    Topics: Animals; Arginine Vasopressin; Blood Pressure; Calcium; Hypercalcemia; Hypertension; Indomethacin; K

1986
Estrogens and antiestrogens stimulate release of bone resorbing activity by cultured human breast cancer cells.
    The Journal of clinical investigation, 1985, Volume: 75, Issue:2

    Topics: Biological Products; Bone Resorption; Breast Neoplasms; Cells, Cultured; Cytokines; Dinoprostone; Es

1985
Familial benign hypercalcemia (hypocalciuric hypercalcemia). Clinical and pathogenetic studies in 21 families.
    Annals of internal medicine, 1985, Volume: 102, Issue:4

    Topics: Adolescent; Adult; Aged; Bone and Bones; Calcium; Female; Humans; Hypercalcemia; Indomethacin; Intes

1985
Elevated prostaglandin and indomethacin-responsive hypercalcemia in a patient with malignant pheochromocytoma.
    The Journal of urology, 1985, Volume: 134, Issue:4

    Topics: Adrenal Gland Neoplasms; Bone Neoplasms; Calcium; Humans; Hypercalcemia; Indomethacin; Male; Middle

1985
Prostaglandins, calcium metabolism and cancer.
    Federation proceedings, 1974, Volume: 33, Issue:1

    Topics: Animals; Aspirin; Bone and Bones; Bone Resorption; Calcium; Calcium Radioisotopes; Cells, Cultured;

1974
Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer.
    The Journal of experimental medicine, 1972, Dec-01, Volume: 136, Issue:6

    Topics: Animals; Bone Neoplasms; Bone Resorption; Calcium; Cells, Cultured; Clone Cells; Culture Techniques;

1972
Letter: Indomethacin, prostaglandin and hypercalcemia.
    The New England journal of medicine, 1974, Oct-10, Volume: 291, Issue:15

    Topics: Alcohol Oxidoreductases; Cyclic AMP; Humans; Hypercalcemia; Indomethacin; Mixed Function Oxygenases;

1974
Successful treatment of hypercalcemia by indomethacin in mice bearing a prostaglandin-producing fibrosarcoma.
    Prostaglandins, 1973, Volume: 3, Issue:4

    Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Bone Resorption; Calcium; Calcium Isot

1973
The inhibition by aspirin and indomethacin of osteolytic tumor deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer.
    British journal of cancer, 1973, Volume: 28, Issue:4

    Topics: Animals; Aspirin; Bone and Bones; Bone Neoplasms; Bone Resorption; Breast Neoplasms; Calcium; Calciu

1973
Indomethacin-responsive hypercalcemia in a patient with renal-cell adenocarcinoma.
    The New England journal of medicine, 1974, Jun-11, Volume: 291, Issue:2

    Topics: Adenocarcinoma; Administration, Oral; Calcium; Humans; Hypercalcemia; Indomethacin; Kidney Neoplasms

1974