indomethacin has been researched along with Hydronephrosis in 15 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Hydronephrosis: Abnormal enlargement or swelling of a KIDNEY due to dilation of the KIDNEY CALICES and the KIDNEY PELVIS. It is often associated with obstruction of the URETER or chronic kidney diseases that prevents normal drainage of urine into the URINARY BLADDER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment of -/- pups with indomethacin from day 1 prevented growth retardation and 10% treated for 3 weeks survived, although as adults they exhibited severe polyuria (10 ml/day), extreme hydronephrosis, low plasma potassium, high blood pH, hypercalciuria, and proteinuria." | 3.70 | Uncompensated polyuria in a mouse model of Bartter's syndrome. ( Chernavvsky, DR; Gitelman, HJ; Gomez, RA; Igarashi, P; Smithies, O; Takahashi, N, 2000) |
| "The effects of mannitol, methylprednisolone, furosemide, inosine, indomethacin and captopril on the recovery from hydronephrosis were examined in rat kidneys." | 3.67 | Pharmacological enhancement of recovery in experimental hydronephrosis. ( Iwata, H; Ochi, K; Takeuchi, M; Yokoyama, M, 1985) |
| " Lipid droplet triglycerides were found to increase during experimental hydronephrosis and after administration of indomethacin, a prostaglandin synthetase and phosphodiesterase inhibitor." | 3.65 | Analyses of renal medullary lipid droplets from normal, hydronephrotic, and indomethacin treated rabbits. ( Comai, K; Farber, SJ; Paulsrud, JR, 1975) |
| "Thromboxane A2 (TXA2) has been reported to be increased in the hydronephrotic kidney, and the present study was undertaken to investigate whether TXA2 might be responsible for these findings." | 1.28 | Effect of thromboxane inhibition on tubuloglomerular feedback in hydronephrotic kidneys. ( Morsing, P; Persson, AE; Stenberg, A, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (53.33) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sohn, YM | 1 |
| Lee, C | 1 |
| Kim, PK | 1 |
| Yun, DJ | 1 |
| Sivakoff, M | 1 |
| Holmberg, S | 1 |
| Needleman, P | 4 |
| Salvemini, D | 2 |
| Seibert, K | 2 |
| Masferrer, JL | 2 |
| Misko, TP | 2 |
| Currie, MG | 2 |
| Settle, SL | 1 |
| Hayashi, K | 1 |
| Loutzenhiser, R | 1 |
| Epstein, M | 1 |
| Suzuki, H | 1 |
| Saruta, T | 1 |
| Endlich, K | 1 |
| Kühn, R | 1 |
| Steinhausen, M | 2 |
| Takahashi, N | 1 |
| Chernavvsky, DR | 1 |
| Gomez, RA | 1 |
| Igarashi, P | 1 |
| Gitelman, HJ | 1 |
| Smithies, O | 1 |
| De Vriese, AS | 1 |
| Van de Voorde, J | 1 |
| Blom, HJ | 1 |
| Vanhoutte, PM | 1 |
| Verbeke, M | 1 |
| Lameire, NH | 1 |
| Nishikawa, K | 1 |
| Morrison, A | 1 |
| Comai, K | 2 |
| Farber, SJ | 2 |
| Paulsrud, JR | 2 |
| Ballantyne, D | 1 |
| Fretschner, M | 1 |
| Parekh, N | 1 |
| Morsing, P | 1 |
| Stenberg, A | 1 |
| Persson, AE | 1 |
| Green, J | 1 |
| Vardy, Y | 1 |
| Munichor, M | 1 |
| Better, OS | 1 |
| Yokoyama, M | 1 |
| Iwata, H | 1 |
| Ochi, K | 1 |
| Takeuchi, M | 1 |
| Prose, P | 1 |
15 other studies available for indomethacin and Hydronephrosis
| Article | Year |
|---|---|
Congenital nephrogenic diabetes insipidus with bilateral hydronephrosis: indomethacin in treatment of nephrogenic diabetes insipidus.
Topics: Adolescent; Chlorothiazide; Diabetes Insipidus; Drug Therapy, Combination; Humans; Hydronephrosis; I | 1980 |
The role of prostaglandins and thromboxane in modulation of perfusion pressure in the hydronephrotic rabbit kidney.
Topics: Angiotensin II; Animals; Hydronephrosis; Indomethacin; Kidney; Perfusion; Prostaglandins; Rabbits; T | 1980 |
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cholic Acids; Dinoprostone; Disease Models, Animal; H | 1994 |
Nitric oxide and the cyclooxygenase pathway.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bradykinin; Dinoprostone; Enzyme Induction; Escherich | 1995 |
Multiple factors contribute to acetylcholine-induced renal afferent arteriolar vasodilation during myogenic and norepinephrine- and KCl-induced vasoconstriction. Studies in the isolated perfused hydronephrotic kidney.
Topics: Acetylcholine; Animals; Arginine; Arterioles; Biological Factors; Hydronephrosis; In Vitro Technique | 1994 |
Visualization of serotonin effects on renal vessels of rats.
Topics: Animals; Blood Vessels; Female; Hydronephrosis; Indomethacin; Kidney; Rats; Rats, Wistar; Receptors, | 1993 |
Uncompensated polyuria in a mouse model of Bartter's syndrome.
Topics: Animals; Bartter Syndrome; Calcium; Carrier Proteins; Disease Models, Animal; Electrolytes; Hydronep | 2000 |
The impaired renal vasodilator response attributed to endothelium-derived hyperpolarizing factor in streptozotocin--induced diabetic rats is restored by 5-methyltetrahydrofolate.
Topics: Acetylcholine; Animals; Biological Factors; Biomarkers; Blood Pressure; Diabetes Mellitus, Experimen | 2000 |
Exaggerated prostaglandin biosynthesis and its influence on renal resistance in the isolated hydronephrotic rabbit kidney.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Arachidonic Acids; Bradykinin; Disease Models, Anim | 1977 |
Analyses of renal medullary lipid droplets from normal, hydronephrotic, and indomethacin treated rabbits.
Topics: Animals; Cholesterol Esters; Fatty Acids; Hydronephrosis; Indomethacin; Kidney; Kidney Cortex; Kidne | 1975 |
Sex differences in autoregulation of juxtamedullary glomerular blood flow in hydronephrotic rats.
Topics: Animals; Female; Homeostasis; Hydronephrosis; Indomethacin; Kidney Cortex; Kidney Glomerulus; Kidney | 1990 |
Effect of thromboxane inhibition on tubuloglomerular feedback in hydronephrotic kidneys.
Topics: Animals; Carbazoles; Extracellular Space; Feedback; Hydronephrosis; Imidazoles; Indomethacin; Kidney | 1989 |
Extreme unilateral hydronephrosis with normal glomerular filtration rate: physiological studies in a case of obstructive uropathy.
Topics: Adult; Dinoprostone; Diuresis; Glomerular Filtration Rate; Humans; Hydronephrosis; Indomethacin; Kid | 1986 |
Pharmacological enhancement of recovery in experimental hydronephrosis.
Topics: Animals; Captopril; Furosemide; Hydronephrosis; Indomethacin; Inosine; Kidney; Kidney Cortex; Kidney | 1985 |
Correlation of renal medullary prostaglandin content and renal interstitial cell lipid droplets.
Topics: Animals; Connective Tissue; Connective Tissue Cells; Depression, Chemical; Dose-Response Relationshi | 1974 |