indomethacin has been researched along with Huntington Disease in 1 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The binding of beta-catenin to the destruction complex is altered in HD, leading to the toxic stabilization of beta-catenin." | 1.36 | Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease. ( Godin, JD; Hickey, MA; Humbert, S; Maschat, F; Poizat, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Godin, JD | 1 |
| Poizat, G | 1 |
| Hickey, MA | 1 |
| Maschat, F | 1 |
| Humbert, S | 1 |
1 other study available for indomethacin and Huntington Disease
| Article | Year |
|---|---|
Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease.
Topics: Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents, Non-Steroidal; Armadillo Domain Proteins | 2010 |