indomethacin has been researched along with Herpes Simplex Virus Infection in 14 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin, a prostaglandin synthetase inhibitor, increased human mononuclear cell (MC) natural killer cytotoxicity (NKC) to herpes simplex virus (HSV) infected cells in vitro at concentrations of 2 X 10(-10)M (p less than ." | 7.66 | Indomethacin enhancement of human natural killer cytotoxicity to herpes simplex virus infected cells in vitro and in vivo. ( Jansen, DM; Kohl, S; Loo, LS, 1982) |
| "In 20 patients with severe herpes simplex, the combined use of levamisole 150 mg/day for 3 days every 2 weeks, plus indomethacin 25 mg daily for a maximum period of 6 months, gave some 75% favourable results." | 7.66 | Levamisole plus indomethacin in the treatment of herpes simplex. ( Hernández-Pérez, E, 1980) |
| "In an open study, continuous oral therapy with cyclooxygenase inhibitors (ibuprofen or indomethacin) reduced the incidence and frequency of recurrent eruptions in nine of 16 patients with herpes simplex virus infection." | 3.68 | The prophylactic use of cyclooxygenase inhibitors in recurrent herpes simplex infections. ( Aurelian, L; Burnett, JW; Wachsman, M, 1990) |
| "In this report we describe results showing that both arachidonic acid (20:4) release and prostaglandin (PG) synthesis in herpes simplex virus type 2 (HSV-2)-transformed tumor-derived rat fibrosarcoma (RFS) cells are inhibited by indomethacin (cyclooxygenase inhibitor)." | 3.67 | Studies of phospholipase and cyclooxygenase activities in herpes simplex virus type 2-transformed rat cells. ( Heitman, CR; Kucera, LS; Waite, M, 1989) |
| " It was not made in UV-HSV-stimulated cultures grown in presence of 2 X 10(-6) M indomethacin nor in cultures of peripheral blood mononuclear cells obtained during convalescence or quiescence (greater than 4 days from onset of clinical symptoms) or from seropositive controls without a history of recurrent HSV disease." | 3.67 | Reactivation of herpes simplex virus is associated with production of a low molecular weight factor that inhibits lymphokine activity in vitro. ( Aurelian, L; Beck, M; Sheridan, JF; Smith, CC, 1987) |
| "Indomethacin, a prostaglandin synthetase inhibitor, increased human mononuclear cell (MC) natural killer cytotoxicity (NKC) to herpes simplex virus (HSV) infected cells in vitro at concentrations of 2 X 10(-10)M (p less than ." | 3.66 | Indomethacin enhancement of human natural killer cytotoxicity to herpes simplex virus infected cells in vitro and in vivo. ( Jansen, DM; Kohl, S; Loo, LS, 1982) |
| "In 20 patients with severe herpes simplex, the combined use of levamisole 150 mg/day for 3 days every 2 weeks, plus indomethacin 25 mg daily for a maximum period of 6 months, gave some 75% favourable results." | 3.66 | Levamisole plus indomethacin in the treatment of herpes simplex. ( Hernández-Pérez, E, 1980) |
| "Indomethacin was used for cyclooxygenase blockade and nordihydroguaiaretic acid was used to evaluate lipoxygenase inhibition." | 1.29 | Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism. ( Donovan, PK; Feinberg, BB; Gonik, B; Loftin, KC; Tan, NS, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Altmann, DM | 1 |
| Blyth, WA | 1 |
| Chang, TW | 1 |
| Kohl, S | 1 |
| Jansen, DM | 1 |
| Loo, LS | 1 |
| Hernández-Pérez, E | 1 |
| Miller, CS | 1 |
| Jacob, RJ | 1 |
| Hiser, DG | 1 |
| Feinberg, BB | 1 |
| Tan, NS | 1 |
| Donovan, PK | 1 |
| Loftin, KC | 1 |
| Gonik, B | 1 |
| Wachsman, M | 1 |
| Aurelian, L | 2 |
| Burnett, JW | 1 |
| Heitman, CR | 1 |
| Waite, M | 1 |
| Kucera, LS | 1 |
| Visser, MR | 1 |
| Tracy, PB | 1 |
| Vercellotti, GM | 1 |
| Goodman, JL | 1 |
| White, JG | 1 |
| Jacob, HS | 1 |
| Sheridan, JF | 1 |
| Beck, M | 1 |
| Smith, CC | 1 |
| Zachariae, H | 1 |
| Niordson, AM | 1 |
| Henningsen, SJ | 1 |
| Inglot, AD | 1 |
| Woytoń, A | 1 |
| Perkins, ES | 1 |
| MacFaul, PA | 1 |
| Saito, T | 1 |
| Sugai, T | 1 |
| Aoki, K | 1 |
3 trials available for indomethacin and Herpes Simplex Virus Infection
| Article | Year |
|---|---|
Indomethacin in urticaria and histamine induced wealing. A double-blind evaluation.
Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Female; Herpes Simplex; Histamine; Humans; | 1969 |
Topical treatment of cutaneous herpes simplex in humans with the non-steroid antiinflammatory drugs: mefenamic acid and indomethacin in dimethylsulfoxide.
Topics: Administration, Topical; Adolescent; Adult; Animals; Cells, Cultured; Chick Embryo; Clinical Trials | 1971 |
Indomethacin in the treatment of uveitis. A double-blind trial.
Topics: Adolescent; Arthritis, Reactive; Clinical Trials as Topic; Colitis, Ulcerative; Diabetes Complicatio | 1965 |
11 other studies available for indomethacin and Herpes Simplex Virus Infection
| Article | Year |
|---|---|
Lipopolysaccharide-induced suppressor cells for delayed-type hypersensitivity to herpes simplex virus: nature of suppressor cell and effect on pathogenesis of herpes simplex.
Topics: Animals; Antibodies, Viral; Cell Movement; Cyclophosphamide; Female; Herpes Simplex; Hypersensitivit | 1984 |
Prostaglandin synthetase inhibitors in primary herpes infections.
Topics: Adolescent; Adult; Child, Preschool; Cyclooxygenase Inhibitors; Female; Herpes Simplex; Humans; Ibup | 1980 |
Indomethacin enhancement of human natural killer cytotoxicity to herpes simplex virus infected cells in vitro and in vivo.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Female; Herpes Simplex; Humans; Indomethacin; Killer | 1982 |
Levamisole plus indomethacin in the treatment of herpes simplex.
Topics: Adult; Drug Therapy, Combination; Female; Herpes Simplex; Humans; Indomethacin; Levamisole; Male | 1980 |
UV-enhanced replication of herpes simplex virus in DNA-repair competent and deficient fibroblasts.
Topics: DNA Repair; DNA Replication; DNA, Viral; Fibroblasts; Herpes Simplex; Humans; Indomethacin; Prostagl | 1993 |
Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism.
Topics: Animals; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Disease Models, Animal; Dose-Re | 1993 |
The prophylactic use of cyclooxygenase inhibitors in recurrent herpes simplex infections.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase Inhibitors; Fe | 1990 |
Studies of phospholipase and cyclooxygenase activities in herpes simplex virus type 2-transformed rat cells.
Topics: Animals; Cell Line; Cell Transformation, Viral; Cycloheximide; Enzyme Induction; Fibrosarcoma; Herpe | 1989 |
Enhanced thrombin generation and platelet binding on herpes simplex virus-infected endothelium.
Topics: Arteriosclerosis; Blood Platelets; Cell Adhesion; Cell Aggregation; Endothelium; Herpes Simplex; Hum | 1988 |
Reactivation of herpes simplex virus is associated with production of a low molecular weight factor that inhibits lymphokine activity in vitro.
Topics: Antigens, Viral; Cells, Cultured; Convalescence; Herpes Simplex; Humans; Indomethacin; Lymphokines; | 1987 |
[Inflammation and anti-inflammatory agents. Non-steroid anti-inflammatory drugs. Management in dermatology].
Topics: Anti-Inflammatory Agents; Herpes Simplex; Humans; Indomethacin; Lupus Erythematosus, Systemic; ortho | 1968 |