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indomethacin and Hemorrhagic Shock

indomethacin has been researched along with Hemorrhagic Shock in 18 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"The effects of hemorrhagic shock (HE) on duodenal HCO3- secretion and mucosal tolerance to acid were investigated in anesthetized rats and compared with those of indomethacin."7.67Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum. A comparative study with indomethacin. ( Nishiwaki, H; Nobuhara, Y; Okabe, S; Takeuchi, K; Tanaka, H, 1988)
"The effects of hemorrhagic shock (HE) on duodenal pH, acid-neutralizing capacity and mucosal tolerance to acid were investigated in anesthetized rats, and they were compared with those of indomethacin."7.67Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock: comparative study with indomethacin. ( Furukawa, O; Nishiwaki, H; Okabe, S; Takeuchi, K; Tanaka, H, 1987)
"We examined effects of indomethacin, meclofenamate, and prostaglandin E1 on systemic arterial pressure, heart rate, cardiac output, and systemic vascular resistance of anesthetized juvenile goats in severe hemorrhagic shock."7.66Effects of indomethacin on cardiovascular hemodynamics of goats in hemorrhagic shock. ( Cassin, S; Leffler, CW; Tyler, TL, 1978)
" Three models of acute gastric damage (ethanol, hemorrhagic shock, and indomethacin) were examined and treatment was also carried out with the antiulcer drugs omeprazole, ranitidine, and misoprostol, to show the advantages of this histomorphometric approach."3.71Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage. ( Blandizzi, C; Del Tacca, M; Gherardi, G; Lazzeri, G; Lenzi, P; Natale, G; Pellegrini, A, 2001)
") on susceptibility to gastrointestinal damage induced by hemorrhagic shock, stress, platelet-activating factor (PAF), indomethacin or endotoxin."3.68Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress and PAF in the rat. ( Boichot, E; Brecx, A; Paubert-Braquet, M; Sidoti, C; Wallace, JL, 1993)
"The effects of hemorrhagic shock (HE) on duodenal HCO3- secretion and mucosal tolerance to acid were investigated in anesthetized rats and compared with those of indomethacin."3.67Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum. A comparative study with indomethacin. ( Nishiwaki, H; Nobuhara, Y; Okabe, S; Takeuchi, K; Tanaka, H, 1988)
"The effects of hemorrhagic shock (HE) on duodenal pH, acid-neutralizing capacity and mucosal tolerance to acid were investigated in anesthetized rats, and they were compared with those of indomethacin."3.67Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock: comparative study with indomethacin. ( Furukawa, O; Nishiwaki, H; Okabe, S; Takeuchi, K; Tanaka, H, 1987)
"The effect of hemorrhagic hypotension on pulmonary dysfunction induced by complement activation was studied in 43 awake sheep, divided into six groups: Group I (n = 6), pulmonary vascular pressure was increased by inflation of a left atrial balloon; group II (n = 9), the complement system was activated by infusion of zymosan activated plasma (ZAP); group III (n = 5), hemorrhagic shock of 50 torr was induced for 3 hr; group IV (n = 10), hemorrhagic shock was induced as in group III, and after 2 hr of shock, ZAP was infused; group V (n = 8), 5 mg/kg of indomethacin was administered before ZAP infusion; group VI (n = 5), pretreatment with indomethacin as in group V, hemorrhagic shock and ZAP as in group IV."3.67Hemorrhagic shock prevents lung microvascular permeability and hypoxemia associated with complement activation in the awake sheep. ( Durst, AL; Eldor, A; Krausz, MM; Moriel, E; Perel, A; Shilo, L, 1987)
"The effects of indomethacin on renal blood flow (RBF) and its distribution were measured during control, during hemorrhage to 70 mm Hg and during refractory shock."3.66Effects of indomethacin on intrarenal blood flow and medullary osmolality in dogs. ( Hock, CE; Leffler, CW; Passmore, JC; Rosenberg, EM, 1980)
"We examined effects of indomethacin, meclofenamate, and prostaglandin E1 on systemic arterial pressure, heart rate, cardiac output, and systemic vascular resistance of anesthetized juvenile goats in severe hemorrhagic shock."3.66Effects of indomethacin on cardiovascular hemodynamics of goats in hemorrhagic shock. ( Cassin, S; Leffler, CW; Tyler, TL, 1978)
"The effect of reperfusion following hemorrhagic shock on splanchnic prostanoid release was studied."1.28Reperfusion inhibits elevated splanchnic prostanoid production after hemorrhagic shock. ( Myers, SI; Stanislawska, M; Taylor, BJ, 1990)
"Pretreatment with indomethacin, a prostaglandin synthesis inhibitor, did not modify the antihypertensive action of captopril."1.27Circulatory effects of renin-angiotensin system antagonists during halothane anaesthesia in hypertensive rats. ( Kataja, J; Kaukinen, S; Ylitalo, P, 1983)
"Indomethacin treatment (15 mg/kg) reduced bleeding volume and diminished the survival rate in haemorrhagically shocked rats."1.26Prostaglandins E1 and E2 antagonize indomethacin-induced decrease in survival rate of haemorrhagically shocked rats. ( Hedqvist, P; Perbeck, L, 1980)
"It is speculated that in hemorrhagic shock enhanced concentration of PGE and other vasodilator PGs, produced in increased amounts by the kidney (and possibly other organs and tissues), appear in greater amounts in the systemic plasma because of the lung's altered function."1.26Role of the kidney and lung in the handling of prostaglandin E in hemorrhagic shock. ( Selkurt, EE, 1978)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199013 (72.22)18.7374
1990's4 (22.22)18.2507
2000's1 (5.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kaukinen, S1
Kataja, J1
Ylitalo, P1
Perbeck, L1
Hedqvist, P1
Passmore, JC2
Rosenberg, EM1
Hock, CE1
Leffler, CW3
Wallace, JL1
Boichot, E1
Sidoti, C1
Brecx, A1
Paubert-Braquet, M1
Pieber, D1
Horina, G1
Sandner-Kiesling, A1
Pieber, TR1
Heinemann, A1
Natale, G1
Lazzeri, G1
Blandizzi, C1
Gherardi, G1
Lenzi, P1
Pellegrini, A1
Del Tacca, M1
Selkurt, EE2
Tyler, TL1
Cassin, S1
Johnston, PA1
Rabinovici, R1
Yue, TL1
Krausz, MM2
Sellers, TS1
Lynch, KM1
Feuerstein, G1
Myers, SI1
Taylor, BJ1
Stanislawska, M1
Urakawa, T1
Nagahata, Y1
Azumi, Y1
Itoh, A1
Sano, I1
Takeda, K1
Hashimoto, Y1
Ichihara, T1
Moritomo, H1
Saitoh, Y1
Takeuchi, K2
Nobuhara, Y1
Tanaka, H2
Nishiwaki, H2
Okabe, S2
Furukawa, O1
Shilo, L1
Moriel, E1
Perel, A1
Eldor, A1
Durst, AL1
Needleman, P2
Kauffman, AH1
Douglas, JR1
Johnson, EM1
Marshall, GR2
Jakschik, BA1
Kourik, JL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Coagulation Activation in Patients With Intracranial Hypertension After Treatment With Mannitol or Hypertonic Saline Solution.[NCT03409237]0 participants (Actual)Observational2020-12-03Withdrawn (stopped due to No participant enrolled. The human resources to perform the study also due to the COBID emegency)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

18 other studies available for indomethacin and Hemorrhagic Shock

ArticleYear
Circulatory effects of renin-angiotensin system antagonists during halothane anaesthesia in hypertensive rats.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:1

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Enflurane; Halothane; H

1983
Prostaglandins E1 and E2 antagonize indomethacin-induced decrease in survival rate of haemorrhagically shocked rats.
    Acta chirurgica Scandinavica. Supplementum, 1980, Volume: 500

    Topics: Animals; Blood Pressure; Female; Indomethacin; Male; Prostaglandin Antagonists; Prostaglandins E; Ra

1980
Effects of indomethacin on intrarenal blood flow and medullary osmolality in dogs.
    Prostaglandins and medicine, 1980, Volume: 5, Issue:4

    Topics: Animals; Dissection; Dogs; Freezing; Hemorrhage; Indomethacin; Kidney; Kidney Cortex; Kidney Medulla

1980
Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress and PAF in the rat.
    Regulatory peptides, 1993, Sep-03, Volume: 47, Issue:2

    Topics: Animals; Endotoxins; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Platelet Activating Factor; R

1993
Pressor and mesenteric arterial hyporesponsiveness to angiotensin II is an early event in haemorrhagic hypotension in anaesthetised rats.
    Cardiovascular research, 1999, Volume: 44, Issue:1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Benzimidazoles; Ben

1999
Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage.
    Toxicology and applied pharmacology, 2001, Jul-01, Volume: 174, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Mis

2001
Role of the kidney and lung in the handling of prostaglandin E in hemorrhagic shock.
    Advances in shock research, 1978, Volume: 1

    Topics: Animals; Aotus trivirgatus; Cyclooxygenase Inhibitors; Dogs; Electrolytes; Indomethacin; Kidney; Lun

1978
Effects of indomethacin on hemodynamics of dogs in refractory hemorrhagic shock.
    The Journal of surgical research, 1977, Volume: 23, Issue:6

    Topics: Animals; Blood Pressure; Cardiac Output; Cyclooxygenase Inhibitors; Dogs; Hemodynamics; Indomethacin

1977
Effects of indomethacin on cardiovascular hemodynamics of goats in hemorrhagic shock.
    Circulatory shock, 1978, Volume: 5, Issue:3

    Topics: Animals; Blood Pressure; Cardiac Output; Goats; Heart Rate; Hemodynamics; Indomethacin; Meclofenamic

1978
Effect of hemorrhagic shock on renal release of prostaglandin E.
    The American journal of physiology, 1976, Volume: 230, Issue:3

    Topics: Aminohippuric Acids; Animals; Blood Pressure; Calcium; Dogs; Hypotension; Indomethacin; Inulin; Kidn

1976
Hemodynamic, hematologic and eicosanoid mediated mechanisms in 7.5 percent sodium chloride treatment of uncontrolled hemorrhagic shock.
    Surgery, gynecology & obstetrics, 1992, Volume: 175, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; alpha-2-Antiplasmin; Angiotensin II; Animals; Eicosanoids; Fibrinogen;

1992
Reperfusion inhibits elevated splanchnic prostanoid production after hemorrhagic shock.
    Annals of surgery, 1990, Volume: 212, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Dinoprostone; Indomethacin; Intestine, Small; Male

1990
The mechanism of acute gastric ulcer after induced hemorrhagic shock.
    Scandinavian journal of gastroenterology, 1989, Volume: 24, Issue:2

    Topics: Acute Disease; Animals; Blood Pressure; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Norepineph

1989
Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum. A comparative study with indomethacin.
    Digestive diseases and sciences, 1988, Volume: 33, Issue:11

    Topics: Animals; Bicarbonates; Duodenum; Gastric Acid; Indomethacin; Intestinal Mucosa; Male; Rats; Rats, In

1988
Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock: comparative study with indomethacin.
    Japanese journal of pharmacology, 1987, Volume: 44, Issue:2

    Topics: Acid-Base Equilibrium; Animals; Duodenum; Hydrochloric Acid; Indomethacin; Intestinal Mucosa; Male;

1987
Hemorrhagic shock prevents lung microvascular permeability and hypoxemia associated with complement activation in the awake sheep.
    Circulatory shock, 1987, Volume: 23, Issue:1

    Topics: Animals; Capillary Permeability; Complement Activation; Consciousness; Hemodynamics; Hypoxia; Indome

1987
Specific stimulation and inhibition of renal prostaglandin release by angiotensin analogs.
    The American journal of physiology, 1973, Volume: 224, Issue:6

    Topics: Angiotensin II; Animals; Bradykinin; Chickens; Colon; Dose-Response Relationship, Drug; Epinephrine;

1973
Profile of circulating vasoactive substances in hemorrhagic shock and their pharmacologic manipulation.
    The Journal of clinical investigation, 1974, Volume: 54, Issue:4

    Topics: Angiotensin II; Animals; Blood Pressure; Carotid Arteries; Catecholamines; Dogs; Hemodynamics; Indom

1974