indomethacin has been researched along with Hemorrhagic Shock in 18 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of hemorrhagic shock (HE) on duodenal HCO3- secretion and mucosal tolerance to acid were investigated in anesthetized rats and compared with those of indomethacin." | 7.67 | Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum. A comparative study with indomethacin. ( Nishiwaki, H; Nobuhara, Y; Okabe, S; Takeuchi, K; Tanaka, H, 1988) |
| "The effects of hemorrhagic shock (HE) on duodenal pH, acid-neutralizing capacity and mucosal tolerance to acid were investigated in anesthetized rats, and they were compared with those of indomethacin." | 7.67 | Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock: comparative study with indomethacin. ( Furukawa, O; Nishiwaki, H; Okabe, S; Takeuchi, K; Tanaka, H, 1987) |
| "We examined effects of indomethacin, meclofenamate, and prostaglandin E1 on systemic arterial pressure, heart rate, cardiac output, and systemic vascular resistance of anesthetized juvenile goats in severe hemorrhagic shock." | 7.66 | Effects of indomethacin on cardiovascular hemodynamics of goats in hemorrhagic shock. ( Cassin, S; Leffler, CW; Tyler, TL, 1978) |
| " Three models of acute gastric damage (ethanol, hemorrhagic shock, and indomethacin) were examined and treatment was also carried out with the antiulcer drugs omeprazole, ranitidine, and misoprostol, to show the advantages of this histomorphometric approach." | 3.71 | Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage. ( Blandizzi, C; Del Tacca, M; Gherardi, G; Lazzeri, G; Lenzi, P; Natale, G; Pellegrini, A, 2001) |
| ") on susceptibility to gastrointestinal damage induced by hemorrhagic shock, stress, platelet-activating factor (PAF), indomethacin or endotoxin." | 3.68 | Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress and PAF in the rat. ( Boichot, E; Brecx, A; Paubert-Braquet, M; Sidoti, C; Wallace, JL, 1993) |
| "The effects of hemorrhagic shock (HE) on duodenal HCO3- secretion and mucosal tolerance to acid were investigated in anesthetized rats and compared with those of indomethacin." | 3.67 | Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum. A comparative study with indomethacin. ( Nishiwaki, H; Nobuhara, Y; Okabe, S; Takeuchi, K; Tanaka, H, 1988) |
| "The effects of hemorrhagic shock (HE) on duodenal pH, acid-neutralizing capacity and mucosal tolerance to acid were investigated in anesthetized rats, and they were compared with those of indomethacin." | 3.67 | Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock: comparative study with indomethacin. ( Furukawa, O; Nishiwaki, H; Okabe, S; Takeuchi, K; Tanaka, H, 1987) |
| "The effect of hemorrhagic hypotension on pulmonary dysfunction induced by complement activation was studied in 43 awake sheep, divided into six groups: Group I (n = 6), pulmonary vascular pressure was increased by inflation of a left atrial balloon; group II (n = 9), the complement system was activated by infusion of zymosan activated plasma (ZAP); group III (n = 5), hemorrhagic shock of 50 torr was induced for 3 hr; group IV (n = 10), hemorrhagic shock was induced as in group III, and after 2 hr of shock, ZAP was infused; group V (n = 8), 5 mg/kg of indomethacin was administered before ZAP infusion; group VI (n = 5), pretreatment with indomethacin as in group V, hemorrhagic shock and ZAP as in group IV." | 3.67 | Hemorrhagic shock prevents lung microvascular permeability and hypoxemia associated with complement activation in the awake sheep. ( Durst, AL; Eldor, A; Krausz, MM; Moriel, E; Perel, A; Shilo, L, 1987) |
| "The effects of indomethacin on renal blood flow (RBF) and its distribution were measured during control, during hemorrhage to 70 mm Hg and during refractory shock." | 3.66 | Effects of indomethacin on intrarenal blood flow and medullary osmolality in dogs. ( Hock, CE; Leffler, CW; Passmore, JC; Rosenberg, EM, 1980) |
| "We examined effects of indomethacin, meclofenamate, and prostaglandin E1 on systemic arterial pressure, heart rate, cardiac output, and systemic vascular resistance of anesthetized juvenile goats in severe hemorrhagic shock." | 3.66 | Effects of indomethacin on cardiovascular hemodynamics of goats in hemorrhagic shock. ( Cassin, S; Leffler, CW; Tyler, TL, 1978) |
| "The effect of reperfusion following hemorrhagic shock on splanchnic prostanoid release was studied." | 1.28 | Reperfusion inhibits elevated splanchnic prostanoid production after hemorrhagic shock. ( Myers, SI; Stanislawska, M; Taylor, BJ, 1990) |
| "Pretreatment with indomethacin, a prostaglandin synthesis inhibitor, did not modify the antihypertensive action of captopril." | 1.27 | Circulatory effects of renin-angiotensin system antagonists during halothane anaesthesia in hypertensive rats. ( Kataja, J; Kaukinen, S; Ylitalo, P, 1983) |
| "Indomethacin treatment (15 mg/kg) reduced bleeding volume and diminished the survival rate in haemorrhagically shocked rats." | 1.26 | Prostaglandins E1 and E2 antagonize indomethacin-induced decrease in survival rate of haemorrhagically shocked rats. ( Hedqvist, P; Perbeck, L, 1980) |
| "It is speculated that in hemorrhagic shock enhanced concentration of PGE and other vasodilator PGs, produced in increased amounts by the kidney (and possibly other organs and tissues), appear in greater amounts in the systemic plasma because of the lung's altered function." | 1.26 | Role of the kidney and lung in the handling of prostaglandin E in hemorrhagic shock. ( Selkurt, EE, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaukinen, S | 1 |
| Kataja, J | 1 |
| Ylitalo, P | 1 |
| Perbeck, L | 1 |
| Hedqvist, P | 1 |
| Passmore, JC | 2 |
| Rosenberg, EM | 1 |
| Hock, CE | 1 |
| Leffler, CW | 3 |
| Wallace, JL | 1 |
| Boichot, E | 1 |
| Sidoti, C | 1 |
| Brecx, A | 1 |
| Paubert-Braquet, M | 1 |
| Pieber, D | 1 |
| Horina, G | 1 |
| Sandner-Kiesling, A | 1 |
| Pieber, TR | 1 |
| Heinemann, A | 1 |
| Natale, G | 1 |
| Lazzeri, G | 1 |
| Blandizzi, C | 1 |
| Gherardi, G | 1 |
| Lenzi, P | 1 |
| Pellegrini, A | 1 |
| Del Tacca, M | 1 |
| Selkurt, EE | 2 |
| Tyler, TL | 1 |
| Cassin, S | 1 |
| Johnston, PA | 1 |
| Rabinovici, R | 1 |
| Yue, TL | 1 |
| Krausz, MM | 2 |
| Sellers, TS | 1 |
| Lynch, KM | 1 |
| Feuerstein, G | 1 |
| Myers, SI | 1 |
| Taylor, BJ | 1 |
| Stanislawska, M | 1 |
| Urakawa, T | 1 |
| Nagahata, Y | 1 |
| Azumi, Y | 1 |
| Itoh, A | 1 |
| Sano, I | 1 |
| Takeda, K | 1 |
| Hashimoto, Y | 1 |
| Ichihara, T | 1 |
| Moritomo, H | 1 |
| Saitoh, Y | 1 |
| Takeuchi, K | 2 |
| Nobuhara, Y | 1 |
| Tanaka, H | 2 |
| Nishiwaki, H | 2 |
| Okabe, S | 2 |
| Furukawa, O | 1 |
| Shilo, L | 1 |
| Moriel, E | 1 |
| Perel, A | 1 |
| Eldor, A | 1 |
| Durst, AL | 1 |
| Needleman, P | 2 |
| Kauffman, AH | 1 |
| Douglas, JR | 1 |
| Johnson, EM | 1 |
| Marshall, GR | 2 |
| Jakschik, BA | 1 |
| Kourik, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Coagulation Activation in Patients With Intracranial Hypertension After Treatment With Mannitol or Hypertonic Saline Solution.[NCT03409237] | 0 participants (Actual) | Observational | 2020-12-03 | Withdrawn (stopped due to No participant enrolled. The human resources to perform the study also due to the COBID emegency) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for indomethacin and Hemorrhagic Shock
| Article | Year |
|---|---|
Circulatory effects of renin-angiotensin system antagonists during halothane anaesthesia in hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Enflurane; Halothane; H | 1983 |
Prostaglandins E1 and E2 antagonize indomethacin-induced decrease in survival rate of haemorrhagically shocked rats.
Topics: Animals; Blood Pressure; Female; Indomethacin; Male; Prostaglandin Antagonists; Prostaglandins E; Ra | 1980 |
Effects of indomethacin on intrarenal blood flow and medullary osmolality in dogs.
Topics: Animals; Dissection; Dogs; Freezing; Hemorrhage; Indomethacin; Kidney; Kidney Cortex; Kidney Medulla | 1980 |
Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress and PAF in the rat.
Topics: Animals; Endotoxins; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Platelet Activating Factor; R | 1993 |
Pressor and mesenteric arterial hyporesponsiveness to angiotensin II is an early event in haemorrhagic hypotension in anaesthetised rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Benzimidazoles; Ben | 1999 |
Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Mis | 2001 |
Role of the kidney and lung in the handling of prostaglandin E in hemorrhagic shock.
Topics: Animals; Aotus trivirgatus; Cyclooxygenase Inhibitors; Dogs; Electrolytes; Indomethacin; Kidney; Lun | 1978 |
Effects of indomethacin on hemodynamics of dogs in refractory hemorrhagic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Cyclooxygenase Inhibitors; Dogs; Hemodynamics; Indomethacin | 1977 |
Effects of indomethacin on cardiovascular hemodynamics of goats in hemorrhagic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Goats; Heart Rate; Hemodynamics; Indomethacin; Meclofenamic | 1978 |
Effect of hemorrhagic shock on renal release of prostaglandin E.
Topics: Aminohippuric Acids; Animals; Blood Pressure; Calcium; Dogs; Hypotension; Indomethacin; Inulin; Kidn | 1976 |
Hemodynamic, hematologic and eicosanoid mediated mechanisms in 7.5 percent sodium chloride treatment of uncontrolled hemorrhagic shock.
Topics: 6-Ketoprostaglandin F1 alpha; alpha-2-Antiplasmin; Angiotensin II; Animals; Eicosanoids; Fibrinogen; | 1992 |
Reperfusion inhibits elevated splanchnic prostanoid production after hemorrhagic shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprost; Dinoprostone; Indomethacin; Intestine, Small; Male | 1990 |
The mechanism of acute gastric ulcer after induced hemorrhagic shock.
Topics: Acute Disease; Animals; Blood Pressure; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Norepineph | 1989 |
Effects of hemorrhagic shock on alkaline secretion and mucosal tolerance to acid in rat duodenum. A comparative study with indomethacin.
Topics: Animals; Bicarbonates; Duodenum; Gastric Acid; Indomethacin; Intestinal Mucosa; Male; Rats; Rats, In | 1988 |
Impairment of acid-neutralizing capacity and lesion formation in the rat duodenum during hemorrhagic shock: comparative study with indomethacin.
Topics: Acid-Base Equilibrium; Animals; Duodenum; Hydrochloric Acid; Indomethacin; Intestinal Mucosa; Male; | 1987 |
Hemorrhagic shock prevents lung microvascular permeability and hypoxemia associated with complement activation in the awake sheep.
Topics: Animals; Capillary Permeability; Complement Activation; Consciousness; Hemodynamics; Hypoxia; Indome | 1987 |
Specific stimulation and inhibition of renal prostaglandin release by angiotensin analogs.
Topics: Angiotensin II; Animals; Bradykinin; Chickens; Colon; Dose-Response Relationship, Drug; Epinephrine; | 1973 |
Profile of circulating vasoactive substances in hemorrhagic shock and their pharmacologic manipulation.
Topics: Angiotensin II; Animals; Blood Pressure; Carotid Arteries; Catecholamines; Dogs; Hemodynamics; Indom | 1974 |