indomethacin has been researched along with Hemorrhage, Peptic Ulcer in 29 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A review has been made of the hospital case notes of 32 patients with indomethacin-associated peptic ulceration seen over a four year period in Dunedin." | 7.66 | Indomethacin-associated peptic ulceration. ( Heads, D; Maclaurin, BP; Richards, DA, 1978) |
| "Indomethacin (2 mg/100 g body weight), induces haemorrhagic gastric ulcers in albino rats." | 3.70 | Gastric mucosal cellular changes induced by indomethacin (NSAID) in male albino rats. ( Ahamed, RN; Sagar, V, 1999) |
| "Studies were performed in three models of acute gastric mucosal damage (induced by oral ethanol, aspirin and indomethacin) and a model of chronic gastritis (induced by 7 day treatment with iodoacetamide) in rats to establish the role of leukotrienes (LTs) in the pathogenesis of these lesions." | 3.69 | Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. ( Gyömber, E; Rainsford, KD; Szabo, S; Vattay, P, 1996) |
| "A review has been made of the hospital case notes of 32 patients with indomethacin-associated peptic ulceration seen over a four year period in Dunedin." | 3.66 | Indomethacin-associated peptic ulceration. ( Heads, D; Maclaurin, BP; Richards, DA, 1978) |
| "Indomethacin (400 mg/day) was administrated orally for 10 days to eight female pigs weighing 36." | 1.36 | Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs. ( Bures, J; Kopácová, M; Kunes, M; Kvetina, J; Osterreicher, J; Pejchal, J; Rejchrt, S; Spelda, S; Tachecí, I, 2010) |
| "When ticlopidine was administered 1h after EtOH, it significantly (p<0." | 1.34 | Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat. ( De Luca, V; Guidobono, F; Lattuada, N; Netti, C; Pagani, F; Sibilia, V; Soglian, A, 2007) |
| "The corticosterone production was inhibited by a single large dose of cortisol as well as by an adrenalectomy." | 1.31 | [The role of endogenous glucocorticoids in maintenance of the gastric mucosa integrity]. ( Bagaeva, TP; Filaretova, LP, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (48.28) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 7 (24.14) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, JI | 1 |
| Park, SW | 1 |
| Lim, JJ | 1 |
| Sohn, SI | 1 |
| Shin, JS | 1 |
| Park, SC | 1 |
| Jang, YP | 1 |
| Chung, EK | 1 |
| Lee, HW | 1 |
| Lee, KT | 1 |
| Tachecí, I | 1 |
| Kvetina, J | 1 |
| Bures, J | 1 |
| Osterreicher, J | 1 |
| Kunes, M | 1 |
| Pejchal, J | 1 |
| Rejchrt, S | 1 |
| Spelda, S | 1 |
| Kopácová, M | 1 |
| Hu, Y | 1 |
| Zhi, Z | 1 |
| Wang, T | 1 |
| Jiang, T | 1 |
| Wang, S | 1 |
| Gharzouli, K | 1 |
| Amira, S | 1 |
| Gharzouli, A | 1 |
| Khennouf, S | 1 |
| Shostak, NA | 1 |
| Riabkova, AA | 1 |
| Savel'ev, VS | 1 |
| Maliarova, LP | 1 |
| Mosina, LM | 1 |
| Vlasov, AP | 1 |
| Plotnikova, NA | 1 |
| Rodina, OP | 1 |
| Sibilia, V | 1 |
| Pagani, F | 1 |
| Lattuada, N | 1 |
| De Luca, V | 1 |
| Guidobono, F | 1 |
| Soglian, A | 1 |
| Netti, C | 1 |
| Morón, F | 1 |
| Mózsik, G | 2 |
| Nagy, L | 2 |
| Patty, I | 1 |
| Tárnok, F | 1 |
| Jávor, T | 2 |
| Feledi, E | 1 |
| Ruzsa, C | 1 |
| Vezekényi, Z | 1 |
| Diamantis, W | 1 |
| Melton, J | 1 |
| Sofia, RD | 1 |
| Ciofalo, VB | 1 |
| Bunton, RW | 1 |
| Barrett, DC | 1 |
| Palmer, DG | 1 |
| Laufer, S | 1 |
| Tries, S | 1 |
| Augustin, J | 1 |
| Elsässer, R | 1 |
| Algate, DR | 1 |
| Atterson, PR | 1 |
| Munt, PL | 1 |
| Gyömber, E | 1 |
| Vattay, P | 1 |
| Szabo, S | 1 |
| Rainsford, KD | 1 |
| Arai, H | 1 |
| Mizuo, M | 1 |
| Marubuchi, S | 1 |
| Nakagawa, M | 1 |
| Mori, Y | 1 |
| Sagar, V | 1 |
| Ahamed, RN | 1 |
| Podvigina, TT | 1 |
| Bogdanov, AI | 1 |
| Filaretova, LP | 2 |
| Bagaeva, TP | 1 |
| Futagami, S | 1 |
| Hiratsuka, T | 1 |
| Wada, K | 1 |
| Tatsuguchi, A | 1 |
| Tsukui, T | 1 |
| Miyake, K | 1 |
| Akamatsu, T | 1 |
| Hosone, M | 1 |
| Sakamoto, C | 1 |
| Kobayashi, M | 1 |
| Maclaurin, BP | 1 |
| Richards, DA | 1 |
| Heads, D | 1 |
| Belousova, IM | 1 |
| Ulak, G | 1 |
| Cingi, MI | 1 |
| Erol, K | 1 |
| Wallace, JL | 1 |
| Cirino, G | 1 |
| De Nucci, G | 1 |
| McKnight, W | 1 |
| MacNaughton, WK | 1 |
| Somerville, K | 1 |
| Faulkner, G | 1 |
| Langman, M | 1 |
| Langridge, CJ | 1 |
| Bodin, F | 1 |
| Conte, M | 1 |
| Dagradi, AE | 1 |
| Falkner, RE | 1 |
| Lee, ER | 1 |
| Rothermich, NO | 1 |
| Emmanuel, JH | 1 |
| Montgomery, RD | 1 |
| Nicoloff, DM | 1 |
1 trial available for indomethacin and Hemorrhage, Peptic Ulcer
| Article | Year |
|---|---|
Gastric microbleeding measurements during one day treatment with indomethacin and indomethacin plus sodium salicylate (1 : 10) in patients.
Topics: Adult; Double-Blind Method; Drug Combinations; Female; Gastric Juice; Gastric Mucosa; Hemoglobinomet | 1984 |
28 other studies available for indomethacin and Hemorrhage, Peptic Ulcer
| Article | Year |
|---|---|
Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury.
Topics: 2-Propanol; Animals; Anti-Ulcer Agents; Artemisia; Dogs; Ethanol; Flavonoids; Gastric Mucosa; Indome | 2017 |
Wireless capsule endoscopy in enteropathy induced by nonsteroidal anti-inflammatory drugs in pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Disease Models, Animal; Duodena | 2010 |
Incorporation of indomethacin nanoparticles into 3-D ordered macroporous silica for enhanced dissolution and reduced gastric irritancy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Carriers; Drug Com | 2011 |
Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat.
Topics: Animals; Aspirin; Carbohydrates; Ethanol; Female; Fructose; Glucose; Honey; Indomethacin; Male; Malt | 2002 |
[Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Duodenal Ulcer; Duodeno | 2003 |
[Experimental assessment of the effect of dimephosphone on ulcerogenesis].
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Gastric Mucosa; Indomethacin; Intestine, Sm | 2004 |
Ticlopidine prevents the formation but delays the healing of ethanol-induced gastric lesions in the rat.
Topics: Administration, Oral; Animals; Aspirin; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Ani | 2007 |
Evidence for the existence of gastric cytoprotective effect of atropine and cimetidine in humans.
Topics: Adult; Atropine; Cimetidine; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastric Mucosa; | 1984 |
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.
Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Biotransformation; Fenoprofen; Ibuprofen; Indometha | 1980 |
Reintroduction of anti-inflammatory drug therapy after drug-associated gastro-intestinal disturbances.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Arthritis; Duodenal Ulcer; Female; Gastrointes | 1982 |
Gastrointestinal tolerance of [2,2-dimethyl-6-(4-chlorophenyl-7-phenyl- 2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid in the rat.
Topics: Acetates; Animals; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; P | 1994 |
Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat.
Topics: Animals; Aspirin; Benzofurans; Ethanol; Female; Gastritis; Indomethacin; Iodoacetamide; Leukotriene | 1996 |
[Effect of T-593 on gastric bleeding and lesions induced by indomethacin and water-immersion stress in rats: improving effect of T-593 on reduced gastric mucosal blood flow in rats].
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Gastric Mucosa; Guanidines; Histamine H2 Antag | 1998 |
Gastric mucosal cellular changes induced by indomethacin (NSAID) in male albino rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Indomethacin; Male; Peptic Ulcer H | 1999 |
[The role of glucocorticoids in healing of indomethacin-induced lesions in the rat gastric mucosa].
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Corticosterone; Glucocorticoids; Hy | 2000 |
[The role of endogenous glucocorticoids in maintenance of the gastric mucosa integrity].
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Corticosterone; Gastric Mu | 2000 |
Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2002 |
Indomethacin-associated peptic ulceration.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; | 1978 |
[Gastrointestinal hemorrhage caused by side effect of drugs].
Topics: Adult; Aged; Aspirin; Butadienes; Drug-Related Side Effects and Adverse Reactions; Female; Humans; I | 1976 |
Gastroprotective effect of nitrendipine on stress-induced gastric lesions in rats.
Topics: Animals; Cold Temperature; Dexamethasone; Female; Immobilization; Indomethacin; Male; Nitrendipine; | 1991 |
Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach.
Topics: Animals; Blood Pressure; Diterpenes; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vas | 1989 |
Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Duodenal Ulcer; Female; Humans; Ibuprofen; Indome | 1986 |
A patient with unusual powers of recovery.
Topics: Aged; Duodenal Ulcer; Humans; Indomethacin; Male; Osteoarthritis; Peptic Ulcer Hemorrhage; Peptic Ul | 1987 |
[Digestive tract hemorrhages following ingestion of anti-inflammatory drugs].
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents; Duodenal Ulcer; Female; Gastrointestinal He | 1969 |
Multiple benign gastric ulcers. A clinical and gastroscopic study.
Topics: Adult; Aged; Alcohol Drinking; Gastroscopy; Humans; Indomethacin; Male; Middle Aged; Peptic Ulcer He | 1974 |
An extended study of indomethacin. I. Clinical pharmacology.
Topics: Adult; Aged; Arthritis; Central Nervous System Diseases; Fibromyalgia; Gastrointestinal Diseases; He | 1966 |
Gastric ulcer and the anti-arthritic drugs.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Indomethacin; Male; Middle Aged; Peptic Ulcer He | 1971 |
Indomethacin. Effect on gastric secretion, parietal cell population, and ulcer provocation in the dog.
Topics: Animals; Dogs; Gastric Juice; Gastric Mucosa; Indomethacin; Peptic Ulcer Hemorrhage; Peptic Ulcer Pe | 1968 |