indomethacin has been researched along with Helicobacter Infections in 26 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs." | 8.02 | Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021) |
| " In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection." | 7.70 | The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000) |
| " pylori infection, indomethacin and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed acetic acid ulcers; and 2) whether or not eradication of the bacteria with drugs at specified times after infection prevents the development of mucosal changes, including gastric adenocarcinoma." | 4.81 | [Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. ( Ebata, M; Keto, Y; Okabe, S, 2001) |
| " speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs." | 4.02 | Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021) |
| " pylori-associated indomethacin-induced gastric ulcers in rats." | 3.73 | Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa. ( Arend, A; Aunapuu, M; Loime, L; Lõivukene, K; Roosaar, P; Selstam, G; Sepp, E; Soom, M; Zilmer, K; Zilmer, M, 2005) |
| " pylori infection, indomethacin, and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed gastric ulcers in Mongolian gerbils." | 3.71 | Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils. ( Ebata, M; Keto, Y; Okabe, S; Tomita, K, 2002) |
| " In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection." | 3.70 | The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000) |
| "In indomethacin and rofecoxib-treated gerbils, the following results were obtained in H pylori-infected group vs H pylori-eradicated group respectively: hyperplasia area of the stomach (mm2): 82." | 1.33 | Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils. ( Chang, CC; Chen, SH; Fang, CL; Hsieh, CR; Lien, GS; Lou, HY; Pan, S, 2005) |
| "Acetic acid ulcers were produced in the rat gastric corpus; non-ulcer rats served as controls." | 1.33 | Cell proliferation in the gastric epithelium of the ulcer rat. ( Helander, HF; Li, H, 2005) |
| "The indomethacin-treated group showed the lowest PGE2 concentration, similar to that of the NS-398 and vehicle-alone treated groups, both without H." | 1.31 | Effects of selective cyclooxygenase-2 inhibitor and non-selective NSAIDs on Helicobacter pylori-induced gastritis in Mongolian gerbils. ( Bhang, CS; Chung, IS; Kim, JI; Kim, SS; Lee, HS; Lee, YS; Park, DH; Song, HJ; Sun, HS; Sung, YJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 21 (80.77) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Siwe, GT | 1 |
| Maharjan, R | 1 |
| Amang, AP | 1 |
| Mezui, C | 1 |
| Zondegoumba, NE | 1 |
| Enow-Orock, GE | 1 |
| Choudhary, MI | 1 |
| Tan, PV | 1 |
| Yanaka, A | 2 |
| Namba, T | 1 |
| Hoshino, T | 1 |
| Suemasu, S | 1 |
| Takarada-Iemata, M | 1 |
| Hori, O | 1 |
| Nakagata, N | 1 |
| Mizushima, T | 1 |
| Elizalde, JI | 1 |
| Mendez, A | 1 |
| Gomez, J | 1 |
| del Rivero, M | 1 |
| Gironella, M | 1 |
| Closa, D | 1 |
| Quintero, E | 1 |
| Pique, JM | 1 |
| Ji, KY | 1 |
| Hu, FJ | 1 |
| Li, AD | 1 |
| Li, J | 1 |
| Tanigawa, T | 1 |
| Watanabe, T | 1 |
| Hamaguchi, M | 1 |
| Sasaki, E | 1 |
| Tominaga, K | 1 |
| Fujiwara, Y | 1 |
| Oshitani, N | 1 |
| Matsumoto, T | 1 |
| Higuchi, K | 1 |
| Arakawa, T | 1 |
| Helander, HF | 2 |
| Poorkhalkali, N | 1 |
| Kanatani, K | 1 |
| Ebata, M | 3 |
| Murakami, M | 1 |
| Okabe, S | 3 |
| Chang, CC | 1 |
| Chen, SH | 1 |
| Lien, GS | 1 |
| Lou, HY | 1 |
| Hsieh, CR | 1 |
| Fang, CL | 1 |
| Pan, S | 1 |
| Arend, A | 1 |
| Loime, L | 1 |
| Roosaar, P | 1 |
| Soom, M | 1 |
| Lõivukene, K | 1 |
| Sepp, E | 1 |
| Aunapuu, M | 1 |
| Zilmer, K | 1 |
| Selstam, G | 1 |
| Zilmer, M | 1 |
| Ebert, MP | 1 |
| Schäfer, C | 1 |
| Chen, J | 1 |
| Hoffmann, J | 1 |
| Gu, P | 1 |
| Kubisch, C | 1 |
| Carl-McGrath, S | 1 |
| Treiber, G | 1 |
| Malfertheiner, P | 1 |
| Röcken, C | 1 |
| Li, H | 1 |
| Suzuki, K | 1 |
| Hayama, M | 1 |
| Nakamura, M | 1 |
| Yamauchi, K | 1 |
| Maruta, F | 1 |
| Miyagawa, S | 1 |
| Ota, H | 1 |
| Thillainayagam, AV | 1 |
| Tabaqchali, S | 1 |
| Warrington, SJ | 1 |
| Farthing, MJ | 1 |
| Stables, R | 1 |
| Campbell, CJ | 1 |
| Clayton, NM | 1 |
| Clitherow, JW | 1 |
| Grinham, CJ | 1 |
| McColm, AA | 1 |
| McLaren, A | 1 |
| Trevethick, MA | 1 |
| Kabir, AM | 1 |
| Shimizu, K | 1 |
| Aiba, Y | 1 |
| Igarashi, M | 2 |
| Takagi, A | 2 |
| Koga, Y | 1 |
| Takahashi, S | 2 |
| Fujita, T | 2 |
| Yamamoto, A | 2 |
| Kim, TI | 1 |
| Lee, YC | 1 |
| Lee, KH | 1 |
| Han, JH | 1 |
| Chon, CY | 1 |
| Moon, YM | 1 |
| Kang, JK | 1 |
| Park, IS | 1 |
| Schraier, M | 1 |
| Petrelli, L | 1 |
| Bonfanti, M | 1 |
| Di Bella, A | 1 |
| Pest, P | 1 |
| Man, F | 1 |
| Adami, J | 1 |
| Tokumoto, M | 1 |
| Slomiany, BL | 1 |
| Piotrowski, J | 1 |
| Slomiany, A | 1 |
| Keto, Y | 2 |
| Bhang, CS | 1 |
| Lee, HS | 1 |
| Kim, SS | 1 |
| Song, HJ | 1 |
| Sung, YJ | 1 |
| Kim, JI | 1 |
| Chung, IS | 1 |
| Sun, HS | 1 |
| Park, DH | 1 |
| Lee, YS | 1 |
| Futagami, S | 1 |
| Hiratsuka, T | 1 |
| Wada, K | 1 |
| Tatsuguchi, A | 1 |
| Tsukui, T | 1 |
| Miyake, K | 1 |
| Akamatsu, T | 1 |
| Hosone, M | 1 |
| Sakamoto, C | 1 |
| Kobayashi, M | 1 |
| Jiang, X | 1 |
| Hasumi, K | 1 |
| Watanabe, S | 1 |
| Deguchi, R | 1 |
| Miwa, T | 1 |
| Tomita, K | 1 |
2 reviews available for indomethacin and Helicobacter Infections
| Article | Year |
|---|---|
Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastritis; Gastrointestin | 2017 |
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils].
Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer | 2001 |
1 trial available for indomethacin and Helicobacter Infections
| Article | Year |
|---|---|
Interrelationships between Helicobacter pylori infection, nonsteroidal antiinflammatory drugs and gastroduodenal disease. A prospective study in healthy volunteers.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Cyclodextrins; Double-Blind Meth | 1994 |
23 other studies available for indomethacin and Helicobacter Infections
| Article | Year |
|---|---|
Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing.
Topics: Acanthaceae; Acetic Acid; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Res | 2021 |
Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Down-Regulation; Endoplasmic Ret | 2010 |
Gastric mucosal blood flow changes in Helicobacter pylori infection and NSAID-induced gastric injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Gastritis; Helicobacter Infections | 2003 |
[Interaction of Helicobacter polyri and indomethacin in gastric mucosa injury of Balb/c mice].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Gastritis; Helicobacter Infections | 2003 |
Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; | 2004 |
Parietal cell density during gastric ulcer healing in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Count; Female; Helicobacte | 2004 |
Effects of indomethacin and rofecoxib on gastric mucosal damage in normal and Helicobacter pylori-infected mongolian gerbils.
Topics: Administration, Oral; Animals; Dinoprostone; Drug Administration Schedule; Drug Synergism; Gastric A | 2004 |
Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Chronic Diseas | 2005 |
Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa.
Topics: Animals; Gastric Mucosa; Glutathione; Helicobacter Infections; Helicobacter pylori; Indomethacin; Li | 2005 |
Protective role of heat shock protein 27 in gastric mucosal injury.
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; | 2005 |
Cell proliferation in the gastric epithelium of the ulcer rat.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Epithelial Cells; | 2005 |
Trefoil factor 2 in gland mucous cell mucin in the mucous gel covering normal or damaged gastric mucosa using the Mongolian gerbil model.
Topics: Animals; Disease Models, Animal; Ethanol; Gastric Mucins; Gastric Mucosa; Gerbillinae; Helicobacter | 2006 |
Gastric anti-secretory, mucosal protective, anti-pepsin and anti-Helicobacter properties of ranitidine bismuth citrate.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Citrates; Dogs; Ethanol; Female; Ferrets; Gastric Acid; Gastric | 1993 |
The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; Chalcone; Chalco | 2000 |
Role of cyclooxygenase-2 in Helicobacter pylori- induced gastritis in Mongolian gerbils.
Topics: Animals; Chemokines; Chemotactic Factors; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhib | 2000 |
Nonsteroidal anti-inflammatory drug-induced acute gastric injury in Helicobacter pylori gastritis in Mongolian gerbils.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Dinoprostone; Gas | 2000 |
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Chronic Disease; Cycloox | 2001 |
[Experimental model of infection of Helicobacter pylori in the mouse. A study of gastric damage caused by indomethacin].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Gastric Mucosa; Helicobact | 2001 |
Up-regulation of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide by aspirin but not indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Disease Models, Animal; Gastri | 2001 |
Effects of selective cyclooxygenase-2 inhibitor and non-selective NSAIDs on Helicobacter pylori-induced gastritis in Mongolian gerbils.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyc | 2002 |
Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2002 |
Analysis of Helicobacter pylori and nonsteroidal anti-inflammatory drug-induced gastric epithelial injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Epithelial Cells; Gastri | 2002 |
Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inh | 2002 |