Page last updated: 2024-10-29

indomethacin and Helicobacter Infections

indomethacin has been researched along with Helicobacter Infections in 26 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.

Research Excerpts

ExcerptRelevanceReference
" speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs."8.02Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021)
" In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection."7.70The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000)
" pylori infection, indomethacin and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed acetic acid ulcers; and 2) whether or not eradication of the bacteria with drugs at specified times after infection prevents the development of mucosal changes, including gastric adenocarcinoma."4.81[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils]. ( Ebata, M; Keto, Y; Okabe, S, 2001)
" speciosa accelerated healing of gastric ulcers even in presence of indomethacin, while decreasing bacterial loads in rats' stomachs."4.02Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing. ( Amang, AP; Choudhary, MI; Enow-Orock, GE; Maharjan, R; Mezui, C; Siwe, GT; Tan, PV; Zondegoumba, NE, 2021)
" pylori-associated indomethacin-induced gastric ulcers in rats."3.73Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa. ( Arend, A; Aunapuu, M; Loime, L; Lõivukene, K; Roosaar, P; Selstam, G; Sepp, E; Soom, M; Zilmer, K; Zilmer, M, 2005)
" pylori infection, indomethacin, and their combination affects the healing of gastric ulcers and whether or not such factors provoke a relapse of healed gastric ulcers in Mongolian gerbils."3.71Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils. ( Ebata, M; Keto, Y; Okabe, S; Tomita, K, 2002)
" In our laboratory, we found that indomethacin-induced gastric ulcers become worse when associated with Helicobacter pylori infection."3.70The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model. ( Aiba, Y; Igarashi, M; Kabir, AM; Koga, Y; Shimizu, K; Takagi, A, 2000)
"In indomethacin and rofecoxib-treated gerbils, the following results were obtained in H pylori-infected group vs H pylori-eradicated group respectively: hyperplasia area of the stomach (mm2): 82."1.33Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils. ( Chang, CC; Chen, SH; Fang, CL; Hsieh, CR; Lien, GS; Lou, HY; Pan, S, 2005)
"Acetic acid ulcers were produced in the rat gastric corpus; non-ulcer rats served as controls."1.33Cell proliferation in the gastric epithelium of the ulcer rat. ( Helander, HF; Li, H, 2005)
"The indomethacin-treated group showed the lowest PGE2 concentration, similar to that of the NS-398 and vehicle-alone treated groups, both without H."1.31Effects of selective cyclooxygenase-2 inhibitor and non-selective NSAIDs on Helicobacter pylori-induced gastritis in Mongolian gerbils. ( Bhang, CS; Chung, IS; Kim, JI; Kim, SS; Lee, HS; Lee, YS; Park, DH; Song, HJ; Sun, HS; Sung, YJ, 2002)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (7.69)18.2507
2000's21 (80.77)29.6817
2010's2 (7.69)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Siwe, GT1
Maharjan, R1
Amang, AP1
Mezui, C1
Zondegoumba, NE1
Enow-Orock, GE1
Choudhary, MI1
Tan, PV1
Yanaka, A2
Namba, T1
Hoshino, T1
Suemasu, S1
Takarada-Iemata, M1
Hori, O1
Nakagata, N1
Mizushima, T1
Elizalde, JI1
Mendez, A1
Gomez, J1
del Rivero, M1
Gironella, M1
Closa, D1
Quintero, E1
Pique, JM1
Ji, KY1
Hu, FJ1
Li, AD1
Li, J1
Tanigawa, T1
Watanabe, T1
Hamaguchi, M1
Sasaki, E1
Tominaga, K1
Fujiwara, Y1
Oshitani, N1
Matsumoto, T1
Higuchi, K1
Arakawa, T1
Helander, HF2
Poorkhalkali, N1
Kanatani, K1
Ebata, M3
Murakami, M1
Okabe, S3
Chang, CC1
Chen, SH1
Lien, GS1
Lou, HY1
Hsieh, CR1
Fang, CL1
Pan, S1
Arend, A1
Loime, L1
Roosaar, P1
Soom, M1
Lõivukene, K1
Sepp, E1
Aunapuu, M1
Zilmer, K1
Selstam, G1
Zilmer, M1
Ebert, MP1
Schäfer, C1
Chen, J1
Hoffmann, J1
Gu, P1
Kubisch, C1
Carl-McGrath, S1
Treiber, G1
Malfertheiner, P1
Röcken, C1
Li, H1
Suzuki, K1
Hayama, M1
Nakamura, M1
Yamauchi, K1
Maruta, F1
Miyagawa, S1
Ota, H1
Thillainayagam, AV1
Tabaqchali, S1
Warrington, SJ1
Farthing, MJ1
Stables, R1
Campbell, CJ1
Clayton, NM1
Clitherow, JW1
Grinham, CJ1
McColm, AA1
McLaren, A1
Trevethick, MA1
Kabir, AM1
Shimizu, K1
Aiba, Y1
Igarashi, M2
Takagi, A2
Koga, Y1
Takahashi, S2
Fujita, T2
Yamamoto, A2
Kim, TI1
Lee, YC1
Lee, KH1
Han, JH1
Chon, CY1
Moon, YM1
Kang, JK1
Park, IS1
Schraier, M1
Petrelli, L1
Bonfanti, M1
Di Bella, A1
Pest, P1
Man, F1
Adami, J1
Tokumoto, M1
Slomiany, BL1
Piotrowski, J1
Slomiany, A1
Keto, Y2
Bhang, CS1
Lee, HS1
Kim, SS1
Song, HJ1
Sung, YJ1
Kim, JI1
Chung, IS1
Sun, HS1
Park, DH1
Lee, YS1
Futagami, S1
Hiratsuka, T1
Wada, K1
Tatsuguchi, A1
Tsukui, T1
Miyake, K1
Akamatsu, T1
Hosone, M1
Sakamoto, C1
Kobayashi, M1
Jiang, X1
Hasumi, K1
Watanabe, S1
Deguchi, R1
Miwa, T1
Tomita, K1

Reviews

2 reviews available for indomethacin and Helicobacter Infections

ArticleYear
Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress.
    Current pharmaceutical design, 2017, Volume: 23, Issue:27

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastric Mucosa; Gastritis; Gastrointestin

2017
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2001, Volume: 118, Issue:4

    Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer

2001

Trials

1 trial available for indomethacin and Helicobacter Infections

ArticleYear
Interrelationships between Helicobacter pylori infection, nonsteroidal antiinflammatory drugs and gastroduodenal disease. A prospective study in healthy volunteers.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Cyclodextrins; Double-Blind Meth

1994

Other Studies

23 other studies available for indomethacin and Helicobacter Infections

ArticleYear
Eremomastax speciosa (Hochst.) Cufod. counteracts the delaying effect of indomethacin on Helicobacter pylori-associated chronic gastric ulcers healing.
    Journal of ethnopharmacology, 2021, Oct-28, Volume: 279

    Topics: Acanthaceae; Acetic Acid; Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Res

2021
Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions.
    The Journal of biological chemistry, 2010, Nov-26, Volume: 285, Issue:48

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Down-Regulation; Endoplasmic Ret

2010
Gastric mucosal blood flow changes in Helicobacter pylori infection and NSAID-induced gastric injury.
    Helicobacter, 2003, Volume: 8, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Gastritis; Helicobacter Infections

2003
[Interaction of Helicobacter polyri and indomethacin in gastric mucosa injury of Balb/c mice].
    Zhonghua yi xue za zhi, 2003, May-10, Volume: 83, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Mucosa; Gastritis; Helicobacter Infections

2003
Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 286, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2;

2004
Parietal cell density during gastric ulcer healing in the rat.
    Scandinavian journal of gastroenterology, 2004, Volume: 39, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Count; Female; Helicobacte

2004
Effects of indomethacin and rofecoxib on gastric mucosal damage in normal and Helicobacter pylori-infected mongolian gerbils.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004, Volume: 55, Issue:1 Pt 2

    Topics: Administration, Oral; Animals; Dinoprostone; Drug Administration Schedule; Drug Synergism; Gastric A

2004
Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils.
    World journal of gastroenterology, 2005, Jan-07, Volume: 11, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Chronic Diseas

2005
Helicobacter pylori substantially increases oxidative stress in indomethacin-exposed rat gastric mucosa.
    Medicina (Kaunas, Lithuania), 2005, Volume: 41, Issue:4

    Topics: Animals; Gastric Mucosa; Glutathione; Helicobacter Infections; Helicobacter pylori; Indomethacin; Li

2005
Protective role of heat shock protein 27 in gastric mucosal injury.
    The Journal of pathology, 2005, Volume: 207, Issue:2

    Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2;

2005
Cell proliferation in the gastric epithelium of the ulcer rat.
    Scandinavian journal of gastroenterology, 2005, Volume: 40, Issue:12

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Epithelial Cells;

2005
Trefoil factor 2 in gland mucous cell mucin in the mucous gel covering normal or damaged gastric mucosa using the Mongolian gerbil model.
    Scandinavian journal of gastroenterology, 2006, Volume: 41, Issue:12

    Topics: Animals; Disease Models, Animal; Ethanol; Gastric Mucins; Gastric Mucosa; Gerbillinae; Helicobacter

2006
Gastric anti-secretory, mucosal protective, anti-pepsin and anti-Helicobacter properties of ranitidine bismuth citrate.
    Alimentary pharmacology & therapeutics, 1993, Volume: 7, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Bismuth; Citrates; Dogs; Ethanol; Female; Ferrets; Gastric Acid; Gastric

1993
The effect of sofalcone on indomethacin-induced gastric ulcers in a Helicobacter pylori-infected gnotobiotic murine model.
    Alimentary pharmacology & therapeutics, 2000, Volume: 14 Suppl 1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; Chalcone; Chalco

2000
Role of cyclooxygenase-2 in Helicobacter pylori- induced gastritis in Mongolian gerbils.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:4

    Topics: Animals; Chemokines; Chemotactic Factors; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhib

2000
Nonsteroidal anti-inflammatory drug-induced acute gastric injury in Helicobacter pylori gastritis in Mongolian gerbils.
    European journal of pharmacology, 2000, Oct-20, Volume: 406, Issue:3

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Dinoprostone; Gas

2000
Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity.
    Infection and immunity, 2001, Volume: 69, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Chronic Disease; Cycloox

2001
[Experimental model of infection of Helicobacter pylori in the mouse. A study of gastric damage caused by indomethacin].
    Acta gastroenterologica Latinoamericana, 2001, Volume: 31, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Gastric Mucosa; Helicobact

2001
Up-regulation of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide by aspirin but not indomethacin.
    Journal of endotoxin research, 2001, Volume: 7, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Disease Models, Animal; Gastri

2001
Effects of selective cyclooxygenase-2 inhibitor and non-selective NSAIDs on Helicobacter pylori-induced gastritis in Mongolian gerbils.
    Helicobacter, 2002, Volume: 7, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyc

2002
Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase

2002
Analysis of Helicobacter pylori and nonsteroidal anti-inflammatory drug-induced gastric epithelial injury.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16 Suppl 2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Epithelial Cells; Gastri

2002
Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils.
    Digestive diseases and sciences, 2002, Volume: 47, Issue:4

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inh

2002