indomethacin has been researched along with Heart Diseases in 17 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although the postpericardiotomy syndrome is a common complication of cardiac operations, the most effective drug regimen for the treatment of this condition has not been established." | 2.67 | The effective treatment of postpericardiotomy syndrome after cardiac operations. A randomized placebo-controlled trial. ( Gardner, TJ; Horneffer, PJ; Miller, RH; Pearson, TA; Reitz, BA; Rykiel, MF, 1990) |
| "Postpericardiotomy syndrome is diagnosed after excluding other conditions such as endocarditis and pneumonia." | 2.37 | Postpericardiotomy syndrome. ( Clark, EB; Leff, RD; McClendon, CE, 1986) |
| "Pretreatment with indomethacin exacerbated coronary flow reduction observed with alpha1 stimulation in failing hearts only." | 1.31 | Altered coronary and cardiac adrenergic response in the failing hamster heart: role of cyclooxygenase derivatives. ( Brousseau, D; Desjardins, JF; Dumont, L; Jasmin, G, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (41.18) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kruse-Elliott, KT | 1 |
| Olson, NC | 1 |
| Moise, KJ | 1 |
| He, GW | 1 |
| Yang, CQ | 1 |
| Takahashi, Y | 1 |
| Harada, K | 1 |
| Ishida, A | 1 |
| Tanaka, T | 1 |
| Tsuda, A | 1 |
| Takada, G | 1 |
| Brousseau, D | 1 |
| Desjardins, JF | 1 |
| Jasmin, G | 1 |
| Dumont, L | 1 |
| Livelli, FD | 1 |
| Johnson, RA | 1 |
| McEnany, MT | 1 |
| Sherman, E | 1 |
| Newell, J | 1 |
| Block, PC | 1 |
| DeSanctis, RW | 1 |
| Kaplan, S | 1 |
| Gaum, WE | 1 |
| Benzing, G | 1 |
| Meyer, RA | 1 |
| Schwartz, DC | 1 |
| Waitman, AD | 1 |
| Koffler, M | 1 |
| Kaplinsky, N | 1 |
| Ganguly, NK | 1 |
| Nalini, K | 1 |
| Wahi, S | 1 |
| Dhawan, V | 1 |
| Meenakshi, S | 1 |
| Chakravarti, RN | 1 |
| Mentz, P | 1 |
| Giessler, C | 1 |
| Horneffer, PJ | 1 |
| Miller, RH | 1 |
| Pearson, TA | 1 |
| Rykiel, MF | 1 |
| Reitz, BA | 1 |
| Gardner, TJ | 1 |
| Santos, PE | 1 |
| Souza, SD | 1 |
| Freire-Maia, L | 1 |
| Almeida, AP | 1 |
| Faist, E | 1 |
| Ertel, W | 1 |
| Salmen, B | 1 |
| Weiler, A | 1 |
| Ressel, C | 1 |
| Bolla, K | 1 |
| Heberer, G | 1 |
| Barrington, PL | 1 |
| Soons, KR | 1 |
| Rosenberg, P | 1 |
| McClendon, CE | 1 |
| Leff, RD | 1 |
| Clark, EB | 1 |
| Dor, V | 1 |
| Malmejac, C | 1 |
| Norirclerc, M | 1 |
| Klotz, H | 1 |
| Prohaska, E | 1 |
| Salmhofer, H | 1 |
| Schmid, L | 1 |
2 reviews available for indomethacin and Heart Diseases
| Article | Year |
|---|---|
Therapeutic advances in pediatric cardiology.
Topics: Adult; Animals; Child; Digitalis Glycosides; Dogs; Ductus Arteriosus; Ductus Arteriosus, Patent; Ech | 1978 |
Postpericardiotomy syndrome.
Topics: Analgesics; Anti-Inflammatory Agents; Diuretics; Heart Diseases; Humans; Indomethacin; Postpericardi | 1986 |
3 trials available for indomethacin and Heart Diseases
| Article | Year |
|---|---|
Unexplained in-hospital fever following cardiac surgery. Natural history, relationship to postpericardiotomy syndrome, and a prospective study of therapy with indomethacin versus placebo.
Topics: Cardiac Surgical Procedures; Clinical Trials as Topic; Cross Infection; Double-Blind Method; Fever; | 1978 |
The effective treatment of postpericardiotomy syndrome after cardiac operations. A randomized placebo-controlled trial.
Topics: Cardiac Surgical Procedures; Double-Blind Method; Female; Heart Diseases; Humans; Ibuprofen; Indomet | 1990 |
The immune-enhancing effect of perioperative thymopentin administration in elderly patients undergoing major surgery.
Topics: Adjuvants, Immunologic; Aged; Cardiopulmonary Bypass; Clinical Trials as Topic; Drug Hypersensitivit | 1988 |
12 other studies available for indomethacin and Heart Diseases
| Article | Year |
|---|---|
CGS 8515 and indomethacin attenuate cytokine-induced cardiopulmonary dysfunction in pigs.
Topics: 6-Ketoprostaglandin F1 alpha; Albumins; Animals; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Ch | 1993 |
Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin use.
Topics: Constriction, Pathologic; Ductus Arteriosus; Echocardiography; Female; Fetal Diseases; Gestational A | 1993 |
Hyperkalemia alters endothelium-dependent relaxation through non-nitric oxide and noncyclooxygenase pathway: a mechanism for coronary dysfunction due to cardioplegia.
Topics: Animals; Cardioplegic Solutions; Coronary Vessels; Cyclooxygenase Inhibitors; Endothelium, Vascular; | 1996 |
Doppler echocardiographic findings of indomethacin-induced occlusion of the fetal ductus arteriosus.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cesarean Section; Cyclooxygenase Inhibitors; Dilatat | 1996 |
Altered coronary and cardiac adrenergic response in the failing hamster heart: role of cyclooxygenase derivatives.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Coronary Circulation; Cricetinae; Cyclooxygena | 2002 |
Bartter's syndrome presenting as pseudomyocardial infarction and pseudogout.
Topics: Angiotensin II; Aspartate Aminotransferases; Bartter Syndrome; Chondrocalcinosis; Creatine Kinase; D | 1992 |
Free radicals in myocardial injury: experimental and clinical studies.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aged; Animals; Calcium; Coronary Artery Disease; Endothelial Gr | 1992 |
Biosynthesis of TXB2 and 6-oxo-PGF1 alpha in the heart and other tissues under pathophysiological conditions.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aqueous Humor; Brain Diseases; Child; Gastric Mucosa; Gastrit | 1992 |
Effects of crotoxin on the isolated guinea pig heart.
Topics: Albumins; Animals; Atropine; Creatine Kinase; Crotalid Venoms; Crotoxin; Electrocardiography; Fatty | 1990 |
Cardiotoxicity of Naja nigricollis phospholipase A2 is not due to alterations in prostaglandin synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Elapid Venoms; Heart Diseases; Hydrolysis; In Vitro Te | 1986 |
[Use of indomethacin during the immediate surgical sequelae of thoracic surgery].
Topics: Adult; Female; Heart Diseases; Humans; Indomethacin; Infection Control; Male; Middle Aged; Postopera | 1968 |
[Gout from the view of a special hospital for rheumatic patients].
Topics: Acute Disease; Adolescent; Adult; Aged; Austria; Child; Cholesterol; Colchicine; Colic; Diabetes Com | 1971 |