indomethacin has been researched along with Granulocytic Leukemia, Chronic in 12 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A patient with chronic myelogenous leukemia who developed arthritis secondary to IFN therapy is presented." | 2.40 | Alpha-interferon-induced arthritis: clinical presentation treatment, and prevention. ( Nesher, G; Ruchlemer, R, 1998) |
| "Indomethacin (IN) can inhibit cyclooxygenase activity and is considered to exert antitumor action in a variety of cancer cells." | 1.33 | Antiproliferative effect of indomethacin on CML cells is related to the suppression of STATs/Bcl-XL signal pathway. ( Fu, Y; Zhang, G, 2006) |
| " 0 approximately 400 micromol/L of IN could down-regulate the expression of p-STAT1 or p-STAT5 in a dose-response manner, p-STATs were distributed mainly in the nucleus as scattering spots." | 1.32 | [Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression]. ( Fu, YB; Xia, M; Zhang, GS, 2004) |
| "The hallmark of chronic myeloid leukemia (CML) is the presence of the bcr-abl oncogene, which is associated with transforming ability and an intrinsic resistance to induction of apoptosis by genotoxic agents." | 1.30 | Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. ( Akard, L; Boswell, HS; Carlo-Stella, C; Dugan, M; Garau, D; Regazzi, E; Rizzo, MT; Rizzoli, V, 1999) |
| "Treatment with indomethacin briefly improved the symptoms, but within 72 hours the patient developed a fulminant illness with high fever and clinical as well as biochemical signs of a severe consumption coagulopathy." | 1.28 | [Atypical joint symptoms as initial symptoms of varicella infection in chronic myeloid leukemia]. ( Arning, M; Aul, C; Bürrig, KF; Reinecke, P; Schneider, W, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heidel, FH | 1 |
| Bullinger, L | 1 |
| Feng, Z | 1 |
| Wang, Z | 1 |
| Neff, TA | 1 |
| Stein, L | 1 |
| Kalaitzidis, D | 1 |
| Lane, SW | 1 |
| Armstrong, SA | 1 |
| Cipák, L | 1 |
| Paulíková, H | 1 |
| Novotný, L | 1 |
| Jarosová, M | 1 |
| Rauko, P | 1 |
| Fu, YB | 2 |
| Zhang, GS | 2 |
| Xia, M | 1 |
| Zhang, G | 4 |
| Fu, Y | 1 |
| Nesher, G | 1 |
| Ruchlemer, R | 1 |
| Rizzo, MT | 1 |
| Regazzi, E | 1 |
| Garau, D | 1 |
| Akard, L | 1 |
| Dugan, M | 1 |
| Boswell, HS | 1 |
| Rizzoli, V | 1 |
| Carlo-Stella, C | 1 |
| Tu, C | 2 |
| Zhou, G | 1 |
| Zheng, W | 1 |
| Lu, H | 1 |
| Maca, RD | 1 |
| Arning, M | 1 |
| Aul, C | 1 |
| Reinecke, P | 1 |
| Bürrig, KF | 1 |
| Schneider, W | 1 |
1 review available for indomethacin and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Alpha-interferon-induced arthritis: clinical presentation treatment, and prevention.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Antineop | 1998 |
11 other studies available for indomethacin and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML.
Topics: Animals; Antineoplastic Agents; Benzamides; beta Catenin; Cyclooxygenase Inhibitors; Drug Resistance | 2012 |
β-catenin inhibition synergizes with imatinib to delay CML recurrence.
Topics: Animals; Antineoplastic Agents; beta Catenin; Cyclooxygenase Inhibitors; Drug Resistance, Neoplasm; | 2012 |
Potentiation of doxorubicin-induced apoptosis and differentiation by indomethacin in K-562 leukemia cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antineoplastic; Apoptosis; Cell Differentiatio | 2004 |
[Proliferation-inhibiting effect of indomethacin on chronic myeliod leukemia cells is related to the supression of STAT signal transduction pathway].
Topics: Antineoplastic Agents; Blotting, Western; Cell Proliferation; Dose-Response Relationship, Drug; Fluo | 2004 |
[Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression].
Topics: bcl-X Protein; Blotting, Western; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; D | 2004 |
Antiproliferative effect of indomethacin on CML cells is related to the suppression of STATs/Bcl-XL signal pathway.
Topics: bcl-X Protein; Cell Division; Humans; Indomethacin; K562 Cells; Leukemia, Myelogenous, Chronic, BCR- | 2006 |
Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Bone Mar | 1999 |
Indomethacin induces apoptosis and inhibits proliferation in chronic myeloid leukemia cells.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Cell Division | 2000 |
[Study of apoptosis induced by indomethacin in chronic myeloid leukemia].
Topics: Apoptosis; Down-Regulation; Humans; Indomethacin; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-AB | 1999 |
Enhancement of etoposide and methotrexate sensitivity by indomethacin in vitro.
Topics: Animals; Bleomycin; Drug Synergism; Etoposide; Humans; Indomethacin; Leukemia, Myelogenous, Chronic, | 1991 |
[Atypical joint symptoms as initial symptoms of varicella infection in chronic myeloid leukemia].
Topics: Adult; Chickenpox; Female; Hip Joint; Humans; Indomethacin; Joint Diseases; Leukemia, Myelogenous, C | 1990 |