indomethacin has been researched along with Gouty Arthritis in 24 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the analgesic effect of IM ketorolac tromethamine with that of oral indomethacin in the treatment of acute gouty arthritis." | 9.08 | Randomized double-blind comparison of the analgesic efficacy of intramuscular ketorolac and oral indomethacin in the treatment of acute gouty arthritis. ( Hayes, JE; Moreden, JM; Morgan, DL; Nelson, M; Shrestha, M; Singh, R, 1995) |
| "Fifty-nine patients with acute gouty arthritis entered into a 7-day multicenter, double blind trial of ketoprofen versus indomethacin." | 9.06 | Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study. ( Altman, RD; Honig, S; Levin, JM; Lightfoot, RW, 1988) |
| "In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin." | 7.77 | A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis. ( Nagar, S; Rasool, M; Sabina, EP, 2011) |
| "To compare the analgesic effect of IM ketorolac tromethamine with that of oral indomethacin in the treatment of acute gouty arthritis." | 5.08 | Randomized double-blind comparison of the analgesic efficacy of intramuscular ketorolac and oral indomethacin in the treatment of acute gouty arthritis. ( Hayes, JE; Moreden, JM; Morgan, DL; Nelson, M; Shrestha, M; Singh, R, 1995) |
| "Fifty-nine patients with acute gouty arthritis entered into a 7-day multicenter, double blind trial of ketoprofen versus indomethacin." | 5.06 | Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study. ( Altman, RD; Honig, S; Levin, JM; Lightfoot, RW, 1988) |
| "To evaluate the efficacy of boswellic acid against monosodium urate crystal-induced inflammation in mice." | 3.78 | Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice. ( Indu, H; Rasool, M; Sabina, EP, 2012) |
| "In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin." | 3.77 | A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis. ( Nagar, S; Rasool, M; Sabina, EP, 2011) |
| "Treatment of acute gouty arthritis with a 5-day course of prednisolone is significantly more cost-effective than treatment with indomethacin." | 3.75 | Oral prednisolone is more cost-effective than oral indomethacin for treating patients with acute gout-like arthritis. ( Cattermole, GN; Cheng, CH; Graham, CA; Man, CY; Rainer, TH, 2009) |
| "In the present study, we have investigated the efficacy of Indian ayurvedic herbal formulation Triphala on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, Indomethacin." | 3.74 | An in vivo and in vitro potential of Indian ayurvedic herbal formulation Triphala on experimental gouty arthritis in mice. ( Rasool, M; Sabina, EP, 2008) |
| "Electroacupuncture combined with local blocking is an effective method for treatment of acute gouty arthritis and it can decrease blood uric acid level." | 2.73 | [Observation on therapeutic effect of electroacupuncture combined with local blocking therapy on acute gouty arthritis]. ( Liu, B; Wang, FY; Wang, HM, 2008) |
| "Patients with the acquired immunodeficiency syndrome (AIDS) are characteristically hypouricemic." | 1.29 | Gouty arthritis in the acquired immunodeficiency syndrome. An unusual but aggressive case. ( Acevedo, M; Cuppari, G; Disla, E; Stein, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 9 (37.50) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sabina, EP | 3 |
| Indu, H | 1 |
| Rasool, M | 5 |
| Li, T | 1 |
| Chen, SL | 1 |
| Dai, Q | 1 |
| Han, XH | 1 |
| Li, ZG | 1 |
| Wu, DH | 1 |
| Zhang, X | 1 |
| Gu, JR | 1 |
| Yang, NP | 1 |
| Sun, LY | 1 |
| Zhang, MJ | 1 |
| Li, XF | 1 |
| Bao, CD | 1 |
| Murunikkara, V | 1 |
| Xu, L | 1 |
| Liu, S | 1 |
| Guan, M | 1 |
| Xue, Y | 1 |
| Zhou, Q | 1 |
| Yu, DH | 1 |
| Zhang, N | 1 |
| Liu, SM | 1 |
| Liu, B | 1 |
| Wang, HM | 1 |
| Wang, FY | 1 |
| Xie, XQ | 1 |
| Cao, YX | 1 |
| Li, F | 1 |
| Meng, Y | 1 |
| Deng, L | 1 |
| Cattermole, GN | 1 |
| Man, CY | 2 |
| Cheng, CH | 1 |
| Graham, CA | 1 |
| Rainer, TH | 2 |
| Nagar, S | 1 |
| Ponce, L | 1 |
| Arjona, M | 1 |
| Blanco, G | 1 |
| Alvarez, S | 1 |
| Arcila, E | 1 |
| Ortega, A | 1 |
| Nuñez, D | 1 |
| Verzura, J | 1 |
| Tovar, R | 1 |
| Bethencourt, S | 1 |
| Riera, R | 1 |
| Mora-Orta, S | 1 |
| Corado, J | 1 |
| Terkeltaub, RA | 1 |
| Schumacher, HR | 2 |
| Carter, JD | 1 |
| Baraf, HS | 1 |
| Evans, RR | 1 |
| Wang, J | 1 |
| King-Davis, S | 1 |
| Weinstein, SP | 1 |
| Borrás-Blasco, J | 1 |
| Enriquez, R | 1 |
| Sirvent, AE | 1 |
| Amoros, F | 1 |
| Navarro-Ruiz, A | 1 |
| Reyes, A | 1 |
| Varalakshmi, P | 1 |
| Cheung, IT | 1 |
| Cameron, PA | 1 |
| Shrestha, M | 1 |
| Morgan, DL | 1 |
| Moreden, JM | 1 |
| Singh, R | 1 |
| Nelson, M | 1 |
| Hayes, JE | 1 |
| Disla, E | 1 |
| Stein, S | 1 |
| Acevedo, M | 1 |
| Cuppari, G | 1 |
| Tan, N | 1 |
| Lertratanakul, Y | 1 |
| Barr, WG | 1 |
| Alloway, JA | 1 |
| Moriarty, MJ | 1 |
| Hoogland, YT | 1 |
| Nashel, DJ | 1 |
| Chou, CT | 1 |
| Kuo, SC | 1 |
| Lo, TS | 1 |
| Buettner, AM | 1 |
| Ingebretson, MC | 1 |
| Boice, JA | 1 |
| Daikh, DI | 1 |
| Mukhopadhyay, S | 1 |
| Malmstrom, K | 1 |
| Ng, J | 1 |
| Tate, GA | 1 |
| Molina, J | 1 |
| Ramanathan, M | 1 |
| Altman, RD | 1 |
| Honig, S | 1 |
| Levin, JM | 1 |
| Lightfoot, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-Center, Randomized, Double-Blind, Active-Controlled Study of the Safety and Efficacy of Rilonacept Administered Subcutaneously for the Treatment of an Acute Gout Flare[NCT00855920] | Phase 3 | 225 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants were asked to complete a daily diary entry and assessed their pain in the past 24 hours using 5-point Likert Scale of 0 (None) to 4 (extreme pain), where; 0= none, 1= mild pain, 2= moderate pain, 3= severe pain, or 4= extreme pain. (NCT00855920)
Timeframe: Baseline (Day 1) to 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo (for Rilonacept) and Indomethacin | -1.16 |
| Rilonacept and Indomethacin | -1.44 |
| Rilonacept and Placebo (for Indomethacin) | -0.55 |
Participants were asked to complete a daily diary entry and assessed their pain in the past 24 hours using 5-point Likert Scale of 0 (None) to 4 (extreme pain), where; 0= none, 1= mild pain, 2= moderate pain, 3= severe pain, or 4= extreme pain. (NCT00855920)
Timeframe: Baseline (Day 1) to 48 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo (for Rilonacept) and Indomethacin | -1.36 |
| Rilonacept and Indomethacin | -1.54 |
| Rilonacept and Placebo (for Indomethacin) | -1.08 |
Participants were asked to complete a daily diary entry and assessed their pain in the past 24 hours using 5-point Likert Scale of 0 (None) to 4 (extreme pain), where; 0= none, 1= mild pain, 2= moderate pain, 3= severe pain, or 4= extreme pain. (NCT00855920)
Timeframe: Baseline (Day 1) to 72 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo (for Rilonacept) and Indomethacin | -1.41 |
| Rilonacept and Indomethacin | -1.57 |
| Rilonacept and Placebo (for Indomethacin) | -1.29 |
Participants were asked to complete a daily diary entry and assessed their pain in the past 24 hours using 5-point Likert Scale of 0 (None) to 4 (extreme pain), where; 0= none, 1= mild pain, 2= moderate pain, 3= severe pain, or 4= extreme pain. Change in PAP-LS in the index joint from baseline (Day 1) to the averaged PAP-LS values at 24, 48 and 72 hours was reported in this outcome measure (averaged PAP value= [PAP at 24 hours + PAP at 48 hours + PAP at 72 hours]/3). (NCT00855920)
Timeframe: Pre-dose on Day 1 (Baseline); post-dose at 4, 8, 12, 24, 48, 72 hours and then daily up to Day 13 or until gout flare ends
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo (for Rilonacept) and Indomethacin | -1.40 |
| Rilonacept and Indomethacin | -1.55 |
| Rilonacept and Placebo (for Indomethacin) | -0.69 |
10 trials available for indomethacin and Gouty Arthritis
| Article | Year |
|---|---|
Etoricoxib versus indometacin in the treatment of Chinese patients with acute gouty arthritis: a randomized double-blind trial.
Topics: Adult; Aged; Arthritis, Gouty; Cyclooxygenase Inhibitors; Double-Blind Method; Etoricoxib; Female; H | 2013 |
Comparison of Prednisolone, Etoricoxib, and Indomethacin in Treatment of Acute Gouty Arthritis: An Open-Label, Randomized, Controlled Trial.
Topics: Adult; Arthritis, Gouty; Etoricoxib; Female; Humans; Indomethacin; Male; Pain Measurement; Prednisol | 2016 |
[Observation on therapeutic effect of electroacupuncture combined with local blocking therapy on acute gouty arthritis].
Topics: Acupuncture Points; Acute Disease; Adult; Aged; Allopurinol; Arthritis, Gouty; Combined Modality The | 2008 |
[Observation on therapeutic effect of surrounded needling therapy on acute gouty arthritis].
Topics: Acupuncture Points; Acupuncture Therapy; Acute Disease; Adult; Aged; Allopurinol; Arthritis, Gouty; | 2009 |
Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator.
Topics: Adolescent; Adult; Aged; Arthritis, Gouty; Double-Blind Method; Female; Gout Suppressants; Humans; I | 2013 |
Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis: a double-blind, randomized, controlled trial.
Topics: Abdominal Pain; Acetaminophen; Acute Disease; Administration, Oral; Aged; Aged, 80 and over; Analges | 2007 |
Randomized double-blind comparison of the analgesic efficacy of intramuscular ketorolac and oral indomethacin in the treatment of acute gouty arthritis.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 1995 |
Comparison of triamcinolone acetonide with indomethacin in the treatment of acute gouty arthritis.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Arthritis, Gouty; Humans; Indomethacin; Injections | 1993 |
Randomised double blind trial of etoricoxib and indometacin in treatment of acute gouty arthritis.
Topics: Acute Disease; Adult; Aged; Arthritis, Gouty; Cyclooxygenase Inhibitors; Double-Blind Method; Etoric | 2002 |
Ketoprofen versus indomethacin in patients with acute gouty arthritis: a multicenter, double blind comparative study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Arthritis, Gouty; Clinical Trials as Topic; Do | 1988 |
14 other studies available for indomethacin and Gouty Arthritis
| Article | Year |
|---|---|
Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Female; Glucuronidase; Hydrolases | 2012 |
Trikatu, a herbal compound that suppresses monosodium urate crystal-induced inflammation in rats, an experimental model for acute gouty arthritis.
Topics: Acute Disease; Alkenes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Female; | 2014 |
Anti-inflammatory Effect of Total Saponin Fraction from Dioscorea nipponica Makino on Gouty Arthritis and Its Influence on NALP3 Inflammasome.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Crystallization; Dioscorea; Indom | 2019 |
Oral prednisolone is more cost-effective than oral indomethacin for treating patients with acute gout-like arthritis.
Topics: Administration, Oral; Anti-Inflammatory Agents; Arthritis, Gouty; Cost-Benefit Analysis; Emergency S | 2009 |
A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Gouty; Benzodi | 2011 |
The effect of montelukast in a model of gouty arthritis induced by sodium monourate crystals.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Cell Migration Assays, | 2011 |
Acute renal failure associated with an accidental overdose of colchicine.
Topics: Acute Kidney Injury; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty | 2005 |
Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Arthritis, Gouty; Cell Line; Humans; Indomethacin; In | 2006 |
An in vivo and in vitro potential of Indian ayurvedic herbal formulation Triphala on experimental gouty arthritis in mice.
Topics: Acetylglucosaminidase; Acid Phosphatase; Administration, Oral; Animals; Ankle Injuries; Anti-Inflamm | 2008 |
Gouty arthritis in the acquired immunodeficiency syndrome. An unusual but aggressive case.
Topics: Acquired Immunodeficiency Syndrome; Arthritis, Gouty; Biopsy, Needle; Colchicine; Humans; Indomethac | 1995 |
Acute gouty arthritis. Modern approaches to an ancient disease.
Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; C | 1993 |
The anti-inflammatory and anti-hyperuricemic effects of Chinese herbal formula danggui-nian-tong-tang on acute gouty arthritis: a comparative study with indomethacin and allopurinol.
Topics: Adolescent; Adult; Aged; Allopurinol; Arthritis, Gouty; Female; Humans; Indomethacin; Lymphocyte Act | 1995 |
Concurrent acute gouty and gonococcal arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Gonorrhea; Gout Suppressants; Humans; Ind | 2002 |
Adult Still's disease: a missed diagnosis.
Topics: Adult; Arthritis, Gouty; Arthritis, Juvenile; Female; Fever; Humans; Indomethacin; Male; Naproxen | 1989 |