indomethacin has been researched along with Glioma in 23 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " One of the NSAIDs, indomethacin, in particular shows promising antineoplastic outcome against glioma." | 7.88 | Indomethacin induced glioma apoptosis involving ceramide signals. ( Chang, CY; Chen, CJ; Chen, WY; Li, JR; Wang, JD; Wang, WY; Wu, CC; Yang, CP, 2018) |
| "The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied." | 7.69 | Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995) |
| " Thus, our results show that polymeric nanocapsules are able to increase the intratumoral bioavailability of indomethacin and reduce the growth of implanted gliomas." | 5.35 | Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model. ( Battastini, AM; Bernardi, A; Braganhol, E; Edelweiss, MI; Figueiró, F; Guterres, SS; Jäger, E; Pohlmann, AR, 2009) |
| "Gliomas are the most common and devastating tumors of the central nervous system." | 5.35 | Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: an in vitro study. ( Battastini, AM; Bavaresco, L; Bernardi, A; Figueiró, F; Frozza, RL; Guterres, SS; Jäger, E; Pohlmann, AR; Salbego, C, 2008) |
| "Indomethacin treatments also increased ATP hydrolysis." | 5.34 | Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines. ( Battastini, AM; Bavaresco, L; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G; Wink, MR, 2007) |
| "Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0." | 5.32 | Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004) |
| " One of the NSAIDs, indomethacin, in particular shows promising antineoplastic outcome against glioma." | 3.88 | Indomethacin induced glioma apoptosis involving ceramide signals. ( Chang, CY; Chen, CJ; Chen, WY; Li, JR; Wang, JD; Wang, WY; Wu, CC; Yang, CP, 2018) |
| " In this study, we investigated the effect of chemically unrelated NSAIDs in the proliferation of glioma cell lines and the possible mechanisms involved in indomethacin-mediated inhibition of proliferation in glioma cells lines." | 3.73 | Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines. ( Battastini, AM; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G, 2006) |
| "The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied." | 3.69 | Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995) |
| " We studied the influence of exogenous prostaglandins and indomethacin on photodynamic therapy of normal human endothelial cells and glioma cells." | 3.68 | Photodynamic treatment of normal endothelial cells or glioma cells in vitro. ( Foultier, MT; Lajat, Y; Patrice, T; Resche, F; Yactayo, S, 1992) |
| "When cultured malignant cells derived from rat gliomas (C6 and 9L) and human gliomas (A-172 and T98G) were treated for 4 hours with 1 to 80 microns nordihydroguaiaretic acid (NDGA) or 5,8,11,14-eicosatetraynoic acid (ETYA), a dose-dependent inhibition of deoxyribonucleic acid (DNA) synthesis occurred." | 3.67 | Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation. ( Anderson, KM; DiGianfilippo, A; Harris, JE; Ondrey, FG; Wilson, DE, 1989) |
| " The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID's (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas." | 3.67 | Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model. ( Del Maestro, RF; Farrell, CL; Reichman, HR, 1986) |
| " Thus, our results show that polymeric nanocapsules are able to increase the intratumoral bioavailability of indomethacin and reduce the growth of implanted gliomas." | 1.35 | Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model. ( Battastini, AM; Bernardi, A; Braganhol, E; Edelweiss, MI; Figueiró, F; Guterres, SS; Jäger, E; Pohlmann, AR, 2009) |
| "Gliomas are the most common and devastating tumors of the central nervous system." | 1.35 | Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: an in vitro study. ( Battastini, AM; Bavaresco, L; Bernardi, A; Figueiró, F; Frozza, RL; Guterres, SS; Jäger, E; Pohlmann, AR; Salbego, C, 2008) |
| "Indomethacin treatments also increased ATP hydrolysis." | 1.34 | Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines. ( Battastini, AM; Bavaresco, L; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G; Wink, MR, 2007) |
| "Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0." | 1.32 | Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, CY | 2 |
| Li, JR | 2 |
| Wu, CC | 2 |
| Wang, JD | 2 |
| Liao, SL | 1 |
| Chen, WY | 2 |
| Wang, WY | 2 |
| Chen, CJ | 2 |
| Yang, CP | 1 |
| Pantovic, A | 1 |
| Bosnjak, M | 1 |
| Arsikin, K | 1 |
| Kosic, M | 1 |
| Mandic, M | 1 |
| Ristic, B | 1 |
| Tosic, J | 1 |
| Grujicic, D | 1 |
| Isakovic, A | 1 |
| Micic, N | 1 |
| Trajkovic, V | 1 |
| Harhaji-Trajkovic, L | 1 |
| Bernardi, A | 4 |
| Braganhol, E | 1 |
| Jäger, E | 2 |
| Figueiró, F | 2 |
| Edelweiss, MI | 1 |
| Pohlmann, AR | 2 |
| Guterres, SS | 2 |
| Battastini, AM | 4 |
| Bähr, O | 1 |
| Rieger, J | 1 |
| Duffner, F | 1 |
| Meyermann, R | 2 |
| Weller, M | 2 |
| Wick, W | 1 |
| Benyahia, B | 1 |
| Huguet, S | 1 |
| Declèves, X | 1 |
| Mokhtari, K | 1 |
| Crinière, E | 1 |
| Bernaudin, JF | 1 |
| Scherrmann, JM | 1 |
| Delattre, JY | 1 |
| Hwang, SL | 1 |
| Lee, KS | 1 |
| Lin, CL | 1 |
| Lieu, AS | 1 |
| Cheng, CY | 1 |
| Loh, JK | 1 |
| Hwang, YF | 1 |
| Su, YF | 1 |
| Howng, SL | 1 |
| Wang, M | 1 |
| Yoshida, D | 1 |
| Liu, S | 1 |
| Teramoto, A | 1 |
| Jacques-Silva, MC | 2 |
| Delgado-Cañedo, A | 2 |
| Lenz, G | 2 |
| Sun, JJ | 1 |
| Wang, ZY | 1 |
| Liu, B | 1 |
| Zhong, YF | 1 |
| Du, J | 1 |
| Chen, YY | 1 |
| Ma, CC | 1 |
| Chen, XD | 1 |
| Bavaresco, L | 2 |
| Wink, MR | 1 |
| Frozza, RL | 1 |
| Salbego, C | 1 |
| Aas, AT | 1 |
| Tønnessen, TI | 1 |
| Brun, A | 1 |
| Salford, LG | 1 |
| Roller, A | 1 |
| Bähr, OR | 1 |
| Streffer, J | 1 |
| Winter, S | 1 |
| Heneka, M | 1 |
| Deininger, M | 1 |
| Naumann, U | 1 |
| Gulbins, E | 1 |
| Kadoyama, K | 1 |
| Takahashi, Y | 1 |
| Higashida, H | 1 |
| Tanabe, T | 1 |
| Yoshimoto, T | 1 |
| Giese, A | 1 |
| Hagel, C | 1 |
| Kim, EL | 1 |
| Zapf, S | 1 |
| Djawaheri, J | 1 |
| Berens, ME | 1 |
| Westphal, M | 1 |
| Foultier, MT | 1 |
| Patrice, T | 1 |
| Yactayo, S | 1 |
| Lajat, Y | 1 |
| Resche, F | 1 |
| Couldwell, WT | 1 |
| Dore-Duffy, P | 1 |
| Apuzzo, ML | 1 |
| Antel, JP | 1 |
| Ohnishi, T | 2 |
| Sher, PB | 1 |
| Posner, JB | 1 |
| Shapiro, WR | 2 |
| Gàti, I | 1 |
| Bergström, M | 1 |
| Westerberg, G | 1 |
| Csòka, K | 1 |
| Muhr, C | 1 |
| Carlsson, J | 1 |
| Wilson, DE | 1 |
| DiGianfilippo, A | 1 |
| Ondrey, FG | 1 |
| Anderson, KM | 1 |
| Harris, JE | 1 |
| Hayakawa, T | 1 |
| Arita, N | 1 |
| Mogami, H | 1 |
| Ushio, Y | 1 |
| Reichman, HR | 1 |
| Farrell, CL | 1 |
| Del Maestro, RF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial[NCT04219358] | Phase 1 | 49 participants (Actual) | Interventional | 2019-03-23 | Terminated (stopped due to Study terminated because of COVID19 pandemics.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 other studies available for indomethacin and Glioma
| Article | Year |
|---|---|
Endoplasmic Reticulum Stress Contributes to Indomethacin-Induced Glioma Apoptosis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Caspases; Cell Line, Tumor; Endoplasmic | 2020 |
Indomethacin induced glioma apoptosis involving ceramide signals.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 8; Cell Line, Tumor; Ceramides; Glioma; | 2018 |
In vitro antiglioma action of indomethacin is mediated via AMP-activated protein kinase/mTOR complex 1 signalling pathway.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; Calcium; | 2017 |
Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Body Weight; Cell Division; Cell | 2009 |
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Tra | 2003 |
Multidrug resistance-associated protein MRP1 expression in human gliomas: chemosensitization to vincristine and etoposide by indomethacin in human glioma cell lines overexpressing MRP1.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Ne | 2004 |
Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Dinoprostone; Dose-Response Relat | 2004 |
Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Brain Neoplasms; Cell Line, Tumor; Cell M | 2005 |
Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferatio | 2006 |
[Inhibiting cerebral glioma growth with continuous low-dose chemotherapy and cyclooxygenase-2 inhibitor in nude mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumo | 2006 |
Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines.
Topics: 5'-Nucleotidase; Actins; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Ant | 2007 |
Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: an in vitro study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Brain Neoplasms; Cell Count | 2008 |
Growth inhibition of rat glioma cells in vitro and in vivo by aspirin.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; | 1995 |
Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: the role of COX-1 and MRP.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; ATP-Binding Cassette Transporters; C | 1999 |
Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzenesulfonates; Cell Division; Cy | 2001 |
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement; | 1999 |
Photodynamic treatment of normal endothelial cells or glioma cells in vitro.
Topics: Animals; Cell Death; Cells, Cultured; Endothelium, Vascular; Glioma; Hematoporphyrin Photoradiation; | 1992 |
Malignant glioma modulation of immune function: relative contribution of different soluble factors.
Topics: Dinoprostone; Glioma; Humans; Immune Tolerance; Immunity; Indomethacin; Lymphocyte Activation; Trans | 1991 |
Capillary permeability factor secreted by malignant brain tumor. Role in peritumoral brain edema and possible mechanism for anti-edema effect of glucocorticoids.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Autoradiography; Brain Edema; | 1990 |
Effects of prostaglandin and leukotriene inhibitors on the growth of human glioma spheroids.
Topics: Arachidonic Acids; Dexamethasone; Glioma; Humans; Indomethacin; Ketoprofen; Leukotriene Antagonists; | 1990 |
Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Catechols; Cell Division; Cell Line; Cell Surviva | 1989 |
[Capillary permeability factor produced by C 6 glioma cells: role in peritumoral brain edema and possible mechanism of glucocorticoid action].
Topics: Animals; Biological Factors; Brain Edema; Brain Neoplasms; Capillary Permeability; Dexamethasone; Gl | 1989 |
Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Capillary Perm | 1986 |