Page last updated: 2024-10-29

indomethacin and Glioma

indomethacin has been researched along with Glioma in 23 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
" One of the NSAIDs, indomethacin, in particular shows promising antineoplastic outcome against glioma."7.88Indomethacin induced glioma apoptosis involving ceramide signals. ( Chang, CY; Chen, CJ; Chen, WY; Li, JR; Wang, JD; Wang, WY; Wu, CC; Yang, CP, 2018)
"The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied."7.69Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995)
" Thus, our results show that polymeric nanocapsules are able to increase the intratumoral bioavailability of indomethacin and reduce the growth of implanted gliomas."5.35Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model. ( Battastini, AM; Bernardi, A; Braganhol, E; Edelweiss, MI; Figueiró, F; Guterres, SS; Jäger, E; Pohlmann, AR, 2009)
"Gliomas are the most common and devastating tumors of the central nervous system."5.35Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: an in vitro study. ( Battastini, AM; Bavaresco, L; Bernardi, A; Figueiró, F; Frozza, RL; Guterres, SS; Jäger, E; Pohlmann, AR; Salbego, C, 2008)
"Indomethacin treatments also increased ATP hydrolysis."5.34Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines. ( Battastini, AM; Bavaresco, L; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G; Wink, MR, 2007)
"Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0."5.32Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004)
" One of the NSAIDs, indomethacin, in particular shows promising antineoplastic outcome against glioma."3.88Indomethacin induced glioma apoptosis involving ceramide signals. ( Chang, CY; Chen, CJ; Chen, WY; Li, JR; Wang, JD; Wang, WY; Wu, CC; Yang, CP, 2018)
" In this study, we investigated the effect of chemically unrelated NSAIDs in the proliferation of glioma cell lines and the possible mechanisms involved in indomethacin-mediated inhibition of proliferation in glioma cells lines."3.73Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines. ( Battastini, AM; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G, 2006)
"The effect of non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (commonly known as aspirin), salicylic acid, piroxicam and indomethacin on the growth of rat glioma cells (RG 2) in vitro and aspirin in vivo was studied."3.69Growth inhibition of rat glioma cells in vitro and in vivo by aspirin. ( Aas, AT; Brun, A; Salford, LG; Tønnessen, TI, 1995)
" We studied the influence of exogenous prostaglandins and indomethacin on photodynamic therapy of normal human endothelial cells and glioma cells."3.68Photodynamic treatment of normal endothelial cells or glioma cells in vitro. ( Foultier, MT; Lajat, Y; Patrice, T; Resche, F; Yactayo, S, 1992)
"When cultured malignant cells derived from rat gliomas (C6 and 9L) and human gliomas (A-172 and T98G) were treated for 4 hours with 1 to 80 microns nordihydroguaiaretic acid (NDGA) or 5,8,11,14-eicosatetraynoic acid (ETYA), a dose-dependent inhibition of deoxyribonucleic acid (DNA) synthesis occurred."3.67Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation. ( Anderson, KM; DiGianfilippo, A; Harris, JE; Ondrey, FG; Wilson, DE, 1989)
" The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID's (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas."3.67Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model. ( Del Maestro, RF; Farrell, CL; Reichman, HR, 1986)
" Thus, our results show that polymeric nanocapsules are able to increase the intratumoral bioavailability of indomethacin and reduce the growth of implanted gliomas."1.35Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model. ( Battastini, AM; Bernardi, A; Braganhol, E; Edelweiss, MI; Figueiró, F; Guterres, SS; Jäger, E; Pohlmann, AR, 2009)
"Gliomas are the most common and devastating tumors of the central nervous system."1.35Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: an in vitro study. ( Battastini, AM; Bavaresco, L; Bernardi, A; Figueiró, F; Frozza, RL; Guterres, SS; Jäger, E; Pohlmann, AR; Salbego, C, 2008)
"Indomethacin treatments also increased ATP hydrolysis."1.34Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines. ( Battastini, AM; Bavaresco, L; Bernardi, A; Delgado-Cañedo, A; Jacques-Silva, MC; Lenz, G; Wink, MR, 2007)
"Indomethacin 8 microM was effective at 1 hour and the inhibition persisted beyond 24 hours (p < 0."1.32Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells. ( Cheng, CY; Howng, SL; Hwang, SL; Hwang, YF; Lee, KS; Lieu, AS; Lin, CL; Loh, JK; Su, YF, 2004)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19903 (13.04)18.7374
1990's7 (30.43)18.2507
2000's10 (43.48)29.6817
2010's2 (8.70)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Chang, CY2
Li, JR2
Wu, CC2
Wang, JD2
Liao, SL1
Chen, WY2
Wang, WY2
Chen, CJ2
Yang, CP1
Pantovic, A1
Bosnjak, M1
Arsikin, K1
Kosic, M1
Mandic, M1
Ristic, B1
Tosic, J1
Grujicic, D1
Isakovic, A1
Micic, N1
Trajkovic, V1
Harhaji-Trajkovic, L1
Bernardi, A4
Braganhol, E1
Jäger, E2
Figueiró, F2
Edelweiss, MI1
Pohlmann, AR2
Guterres, SS2
Battastini, AM4
Bähr, O1
Rieger, J1
Duffner, F1
Meyermann, R2
Weller, M2
Wick, W1
Benyahia, B1
Huguet, S1
Declèves, X1
Mokhtari, K1
Crinière, E1
Bernaudin, JF1
Scherrmann, JM1
Delattre, JY1
Hwang, SL1
Lee, KS1
Lin, CL1
Lieu, AS1
Cheng, CY1
Loh, JK1
Hwang, YF1
Su, YF1
Howng, SL1
Wang, M1
Yoshida, D1
Liu, S1
Teramoto, A1
Jacques-Silva, MC2
Delgado-Cañedo, A2
Lenz, G2
Sun, JJ1
Wang, ZY1
Liu, B1
Zhong, YF1
Du, J1
Chen, YY1
Ma, CC1
Chen, XD1
Bavaresco, L2
Wink, MR1
Frozza, RL1
Salbego, C1
Aas, AT1
Tønnessen, TI1
Brun, A1
Salford, LG1
Roller, A1
Bähr, OR1
Streffer, J1
Winter, S1
Heneka, M1
Deininger, M1
Naumann, U1
Gulbins, E1
Kadoyama, K1
Takahashi, Y1
Higashida, H1
Tanabe, T1
Yoshimoto, T1
Giese, A1
Hagel, C1
Kim, EL1
Zapf, S1
Djawaheri, J1
Berens, ME1
Westphal, M1
Foultier, MT1
Patrice, T1
Yactayo, S1
Lajat, Y1
Resche, F1
Couldwell, WT1
Dore-Duffy, P1
Apuzzo, ML1
Antel, JP1
Ohnishi, T2
Sher, PB1
Posner, JB1
Shapiro, WR2
Gàti, I1
Bergström, M1
Westerberg, G1
Csòka, K1
Muhr, C1
Carlsson, J1
Wilson, DE1
DiGianfilippo, A1
Ondrey, FG1
Anderson, KM1
Harris, JE1
Hayakawa, T1
Arita, N1
Mogami, H1
Ushio, Y1
Reichman, HR1
Farrell, CL1
Del Maestro, RF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial[NCT04219358]Phase 149 participants (Actual)Interventional2019-03-23Terminated (stopped due to Study terminated because of COVID19 pandemics.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

23 other studies available for indomethacin and Glioma

ArticleYear
Endoplasmic Reticulum Stress Contributes to Indomethacin-Induced Glioma Apoptosis.
    International journal of molecular sciences, 2020, Jan-15, Volume: 21, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Caspases; Cell Line, Tumor; Endoplasmic

2020
Indomethacin induced glioma apoptosis involving ceramide signals.
    Experimental cell research, 2018, 04-01, Volume: 365, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 8; Cell Line, Tumor; Ceramides; Glioma;

2018
In vitro antiglioma action of indomethacin is mediated via AMP-activated protein kinase/mTOR complex 1 signalling pathway.
    The international journal of biochemistry & cell biology, 2017, Volume: 83

    Topics: Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Apoptosis; Calcium;

2017
Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model.
    Cancer letters, 2009, Aug-18, Volume: 281, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Body Weight; Cell Division; Cell

2009
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
    Brain pathology (Zurich, Switzerland), 2003, Volume: 13, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Tra

2003
Multidrug resistance-associated protein MRP1 expression in human gliomas: chemosensitization to vincristine and etoposide by indomethacin in human glioma cell lines overexpressing MRP1.
    Journal of neuro-oncology, 2004, Volume: 66, Issue:1-2

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain Ne

2004
Effect of aspirin and indomethacin on prostaglandin E2 synthesis in C6 glioma cells.
    The Kaohsiung journal of medical sciences, 2004, Volume: 20, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms; Dinoprostone; Dose-Response Relat

2004
Inhibition of cell invasion by indomethacin on glioma cell lines: in vitro study.
    Journal of neuro-oncology, 2005, Volume: 72, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Assay; Brain Neoplasms; Cell Line, Tumor; Cell M

2005
Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines.
    European journal of pharmacology, 2006, Feb-27, Volume: 532, Issue:3

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferatio

2006
[Inhibiting cerebral glioma growth with continuous low-dose chemotherapy and cyclooxygenase-2 inhibitor in nude mice].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2006, Jun-18, Volume: 38, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumo

2006
Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines.
    European journal of pharmacology, 2007, Aug-13, Volume: 569, Issue:1-2

    Topics: 5'-Nucleotidase; Actins; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Ant

2007
Selective cytotoxicity of indomethacin and indomethacin ethyl ester-loaded nanocapsules against glioma cell lines: an in vitro study.
    European journal of pharmacology, 2008, May-31, Volume: 586, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Brain Neoplasms; Cell Count

2008
Growth inhibition of rat glioma cells in vitro and in vivo by aspirin.
    Journal of neuro-oncology, 1995, Volume: 24, Issue:2

    Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brain Neoplasms;

1995
Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: the role of COX-1 and MRP.
    Biochemical and biophysical research communications, 1999, Jun-16, Volume: 259, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; ATP-Binding Cassette Transporters; C

1999
Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells.
    Biochemical and biophysical research communications, 2001, Feb-23, Volume: 281, Issue:2

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzenesulfonates; Cell Division; Cy

2001
Thromboxane synthase regulates the migratory phenotype of human glioma cells.
    Neuro-oncology, 1999, Volume: 1, Issue:1

    Topics: Arachidonic Acids; Aspirin; Astrocytes; Benzofurans; Brain Neoplasms; Cell Adhesion; Cell Movement;

1999
Photodynamic treatment of normal endothelial cells or glioma cells in vitro.
    Surgical neurology, 1992, Volume: 37, Issue:2

    Topics: Animals; Cell Death; Cells, Cultured; Endothelium, Vascular; Glioma; Hematoporphyrin Photoradiation;

1992
Malignant glioma modulation of immune function: relative contribution of different soluble factors.
    Journal of neuroimmunology, 1991, Volume: 33, Issue:2

    Topics: Dinoprostone; Glioma; Humans; Immune Tolerance; Immunity; Indomethacin; Lymphocyte Activation; Trans

1991
Capillary permeability factor secreted by malignant brain tumor. Role in peritumoral brain edema and possible mechanism for anti-edema effect of glucocorticoids.
    Journal of neurosurgery, 1990, Volume: 72, Issue:2

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Autoradiography; Brain Edema;

1990
Effects of prostaglandin and leukotriene inhibitors on the growth of human glioma spheroids.
    European journal of cancer (Oxford, England : 1990), 1990, Volume: 26, Issue:7

    Topics: Arachidonic Acids; Dexamethasone; Glioma; Humans; Indomethacin; Ketoprofen; Leukotriene Antagonists;

1990
Effect of nordihydroguaiaretic acid on cultured rat and human glioma cell proliferation.
    Journal of neurosurgery, 1989, Volume: 71, Issue:4

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Catechols; Cell Division; Cell Line; Cell Surviva

1989
[Capillary permeability factor produced by C 6 glioma cells: role in peritumoral brain edema and possible mechanism of glucocorticoid action].
    No to shinkei = Brain and nerve, 1989, Volume: 41, Issue:11

    Topics: Animals; Biological Factors; Brain Edema; Brain Neoplasms; Capillary Permeability; Dexamethasone; Gl

1989
Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model.
    Journal of neurosurgery, 1986, Volume: 65, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Capillary Perm

1986