indomethacin has been researched along with Gastrointestinal Hemorrhage in 138 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers." | 7.75 | EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009) |
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 7.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| "A case is reported in which exposure to cocaine and indomethacin was associated with development of fetal anuria, anasarca, and neonatal gastrointestinal hemorrhage." | 7.68 | Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding. ( Angel, JL; Carlan, SJ; Harris, M; O'Brien, WF; Stromquist, C, 1991) |
| " We used the GRADE approach to assess the certainty of evidence for the following outcomes: failure of PDA closure within one week of administration of the first dose of indomethacin; bronchopulmonary dysplasia (BPD) at 28 days' postnatal age and at 36 weeks' postmenstrual age; proportion of infants requiring surgical ligation or transcatheter occlusion; all-cause neonatal mortality; necrotizing enterocolitis (NEC) (≥ Bell stage 2); and mucocutaneous or gastrointestinal bleeding." | 5.12 | Indomethacin for symptomatic patent ductus arteriosus in preterm infants. ( Evans, P; Flyer, JN; Mitra, S; O'Reilly, D; Soll, R, 2021) |
| "In a previous study oral prostaglandin E2 (PGE2) was shown to protect against indomethacin-induced gastrointestinal bleeding in patients with rheumatic diseases." | 5.05 | Gastrointestinal protection by low-dose oral prostaglandin E2 in rheumatic diseases. ( Johansson, C; Kollberg, B; Nordemar, R, 1981) |
| " Oral ibuprofen is associated with lower instance of necrotizing enterocolitis." | 4.95 | Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options. ( Keim-Malpass, J; Prescott, S, 2017) |
| "Three preterm infants exposed antenatally to indomethacin developed a characteristic syndrome consisting of edema and hydrops with a bleeding disorder at birth, oliguric renal failure during the first 3 postnatal days, and acute pneumoperitoneum resulting from localized ileal perforation(s) at the end of the first week of life." | 4.77 | Oligohydramnios, renal insufficiency, and ileal perforation in preterm infants after intrauterine exposure to indomethacin. ( Coppens, M; Cuvelier, C; de Praeter, C; Dhont, M; Govaert, P; Leroy, JG; Thiery, M; Vanhaesebrouck, P, 1988) |
| " However, there is lack of evidence that fluvoxamine recruits Hsp70 to affect stress-induced gastric ulcer." | 3.91 | Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70. ( Ardianto, C; Aryani, T; Dinintia, Y; Khotib, J; Nisak, K; Oktavia, R; Rahmadi, M; Ratnasari, A; Shinta, DW, 2019) |
| "To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA." | 3.79 | Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants. ( Bali, V; Harabor, A; Kamaluddeen, M; Sivanandan, S; Soraisham, AS, 2013) |
| "To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers." | 3.75 | EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009) |
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 3.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| "A case is reported in which exposure to cocaine and indomethacin was associated with development of fetal anuria, anasarca, and neonatal gastrointestinal hemorrhage." | 3.68 | Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding. ( Angel, JL; Carlan, SJ; Harris, M; O'Brien, WF; Stromquist, C, 1991) |
| " prevented formation of ulcers induced by serotonin, indomethacin, acetylsalicylic acid or stress (acute ulcer models), its effect being greater against gastric ulcers induced by serotonin." | 3.67 | Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103). ( Hoshina, K; Naruchi, T; Takeshita, T; Yamazaki, N, 1985) |
| "Lithium chloride was evaluated as a potential protective agent against ethanol-induced hemorrhagic gastritis in rats." | 3.67 | Lithium chloride: protective and antisecretory properties in rats. ( Boedeker, B; Hickey, TM; Johnson, LF; Wilkinson, DS; Wong, RK, 1984) |
| "Twelve patients with rheumatic diseases took part in a 6-week double-blind crossover trial comparing 14 days of oral with 14 days of rectal indomethacin treatment, 50 mg 3 X /day, with a 14-day placebo period." | 3.67 | Endoscopic evaluation of the effect of indomethacin capsules and suppositories on the gastric mucosa in rheumatic patients. ( Hansen, TM; Madsen, P; Matzen, P, 1984) |
| "Indomethacin has been the standard treatment to close a PDA but is associated with renal, gastrointestinal, and cerebral side effects." | 2.66 | Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. ( Ohlsson, A; Shah, SS, 2020) |
| "Indomethacin levels were significantly higher 2 h after Indocid-R than with indomethacin BP or indomethacin Continus." | 2.66 | Effect in man of aspirin, standard indomethacin, and sustained release indomethacin preparations on gastric bleeding. ( Hawkey, CJ; Poniatowska, TJ; Prichard, PJ; Ravenscroft, AT; Willars, JE, 1988) |
| "The 75% patent ductus arteriosus closure rate with indomethacin treatment in phase 1 was not statistically significant due to a 44% spontaneous closure rate in the control group." | 2.65 | Indomethacin treatment for symptomatic patent ductus arteriosus: a double-blind control study. ( Aziz, KU; Hunt, CE; Newfeld, EA; Wilson, A; Yanagi, RM, 1981) |
| "Piroxicam-beta-cyclodextrin (PBC), a complex of piroxicam with beta-cyclodextrin, was developed with the aim of improving the hydrosolubility and bioavailability of piroxicam." | 2.38 | Effects of piroxicam-beta-cyclodextrin on the gastrointestinal tract. ( Warrington, S, 1993) |
| " Some of the newer NSAIDs seem at normal dosage to be far less damaging than traditional ASA or indomethacin." | 2.37 | Gastroduodenal damage due to drugs, alcohol and smoking. ( Domschke, S; Domschke, W, 1984) |
| " faecalisovergrowth was independent of the route of administration of the drug, as similar findings were observed in rats orally dosed with theNSAID Bile secretion plays an important role inINDO-induced gut injury and appears to support enterococcal overgrowth of the intestine." | 1.43 | Indomethacin injury to the rat small intestine is dependent upon biliary secretion and is associated with overgrowth of enterococci. ( Cruz, MR; Dial, EJ; Garsin, DA; Lichtenberger, LM; Mayo, SA; Murray, BE; Phan, TM; Singh, KV; Song, YK, 2016) |
| "Indomethacin is a powerful analgesic nonsteroidal anti-inflammatory drug (NSAID), but is limited in use by its primary side effect to cause gastrointestinal bleeding and serious injury." | 1.42 | In vitro evidence that phosphatidylcholine protects against indomethacin/bile acid-induced injury to cells. ( Dawson, PA; Dial, EJ; Lichtenberger, LM, 2015) |
| "Cotreatment with omeprazole did not reduce indomethacin-induced intestinal bleeding." | 1.42 | Suppression of contractile activity in the small intestine by indomethacin and omeprazole. ( Bhattarai, D; Dial, EJ; Lichtenberger, LM; Phan, TM; Uray, K, 2015) |
| "Although oliguria was observed in 43 infants (51%) and slight gastrointestinal bleeding was observed in 12 (14%), no infants had severe complications such as intracranial bleeding." | 1.39 | Effects of indomethacin on patent ductus arteriosus in neonates with genetic disorders and/or congenital anomalies. ( Hoshika, A; Ishida, T; Kawakami, T; Kondo, A; Morichi, S; Sunohara, D; Takami, T; Yoda, H, 2013) |
| "Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that is limited in its enteral or parenteral use by side effects of gastroduodenal bleeding and ulceration." | 1.35 | Gastrointestinal safety and therapeutic efficacy of parenterally administered phosphatidylcholine-associated indomethacin in rodent model systems. ( Dial, EJ; Lichtenberger, L; Romero, JJ, 2009) |
| "Acute gastrointestinal hemorrhage from a gastroaortic fistula in the gastric fundoplication pouch is a rare complication of Nissen fundoplication." | 1.35 | Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use. ( Depew, WT; Hurlbut, DJ; Manduch, M; Mercer, CD; Rossiter, JP, 2008) |
| "Portal hypertension was induced by partial portal vein ligation (PVL)." | 1.31 | Effects of prostacyclin inhibition on splanchnic hyposensitivity to glypressin in a hemorrhage-transfused rat model of portal hypertension. ( Chan, CC; Chang, FY; Chu, CJ; Lee, FY; Lee, SD; Lin, HC; Wang, SS; Wu, SL, 2000) |
| "We tried to produce a new ulcerative colitis model in rats by topical administration of sulfhydryl blockers." | 1.30 | New ulcerative colitis model induced by sulfhydryl blockers in rats and the effects of antiinflammatory drugs on the colitis. ( Sato, F; Satoh, H; Szabo, S; Takami, K, 1997) |
| "Pretreatment with omeprazole (30 mg/kg s." | 1.30 | Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress. ( Arakawa, T; Higuchi, K; Kobayashi, K; Kuroki, T; Takaishi, O; Yamasaki, K, 1999) |
| "Indomethacin (25 mg/kg) was given subcutaneously, and gastric acid secretion, motility, lipid peroxidation, vascular permeability, and myeloperoxidase as well as gastric lesions were measured." | 1.29 | Diethyldithiocarbamate, a superoxide dismutase inhibitor, reduces indomethacin-induced gastric lesions in rats. ( Ohuchi, T; Takehara, K; Takeuchi, K, 1996) |
| "Pretreatment with indomethacin, 10 mg/kg s." | 1.29 | Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins. ( Marhuenda, E; Martín, MJ; Pérez Guerrero, C, 1994) |
| "If aspirin was administered subcutaneously or intrajejunally for 20 days, neither adaptation nor inflammation of the gastric mucosa was observed." | 1.29 | Adaptation of rat gastric mucosa to aspirin requires mucosal contact. ( Bell, CJ; McKnight, GW; Wallace, JL, 1995) |
| "The effects of chronic superficial injury on the stomach were studied in rats dosed with a mild irritant (2 mol/L NaCl intragastrically) every 48 hours for 1 month followed by 1-month recovery." | 1.28 | Effects of chronic superficial injury on the rat gastric mucosa. ( Cowart, KS; Hund, P; Lacy, ER, 1992) |
| "Pretreatment with hydrocortisone acetate (20 or 40 mg/kg, s." | 1.28 | Gastric bleeding and increased gastric vascular permeability induced by platelet activating factor (PAF): effect of drugs that affect arachidonate metabolism. ( Hatakeyama, K; Watanabe, K; Yano, S, 1991) |
| "Pretreatment with acetazolamide potentiated the production of S-adenosylmethionine in response to alcohol injury, but it did not modify the protective effect of S-adenosylmethionine against injury by indomethacin." | 1.28 | [Gastric lesions induced by ethanol and indomethacin: cytoprotective effect of acetazolamide]. ( Gutiérrez Cabano, CA, 1990) |
| "We report on 3 cases in which ano-rectal lesions were associated with chronic administration of suppositories containing non-steroidal anti-inflammatory drugs (NSAID)." | 1.28 | Ano-rectal lesions in patients taking suppositories containing non-steroidal anti-inflammatory drugs (NSAID). ( Biasco, G; Brandi, G; Di Febo, G; Gizzi, G; Paganelli, GM; Villani, V, 1990) |
| "Nabumetone was less potent and less active in inhibiting the production of gastric mucosal 6-keto-PGF1 alpha compared with indomethacin either ex-vivo or in-vitro." | 1.27 | Comparison of the effects of nabumetone with indomethacin on rat gastric mucosal 6-keto-PGF1 alpha production and on bile salt-induced changes in gastric mucosal function. ( Melarange, R; Rashbrook, LC, 1987) |
| " Such animals are then labeled with 51Cr-red blood cells from donor animals and dosed with the compound under evaluation." | 1.27 | Assessment of gastric bleeding in rats: effects of cyclooxygenase inhibitors and 16,16-dimethyl prostaglandin E2 on gastric bleeding. ( Argenbright, LW; Bailey, P; Bonney, RJ; Glinka, S; Hopple, S; Humes, JL, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 77 (55.80) | 18.7374 |
| 1990's | 32 (23.19) | 18.2507 |
| 2000's | 15 (10.87) | 29.6817 |
| 2010's | 12 (8.70) | 24.3611 |
| 2020's | 2 (1.45) | 2.80 |
| Authors | Studies |
|---|---|
| Hagmann, WK | 1 |
| Dorn, CP | 1 |
| Frankshun, RA | 1 |
| O'Grady, LA | 1 |
| Bailey, PJ | 1 |
| Rackham, A | 1 |
| Dougherty, HW | 1 |
| Khanna, IK | 1 |
| Yu, Y | 1 |
| Huff, RM | 1 |
| Weier, RM | 1 |
| Xu, X | 1 |
| Koszyk, FJ | 1 |
| Collins, PW | 1 |
| Cogburn, JN | 1 |
| Isakson, PC | 1 |
| Koboldt, CM | 1 |
| Masferrer, JL | 1 |
| Perkins, WE | 1 |
| Seibert, K | 1 |
| Veenhuizen, AW | 1 |
| Yuan, J | 1 |
| Yang, DC | 1 |
| Zhang, YY | 1 |
| Nagai, N | 1 |
| Sakamoto, R | 1 |
| Yamamoto, S | 1 |
| Deguchi, S | 1 |
| Otake, H | 1 |
| Tanino, T | 1 |
| Ohlsson, A | 1 |
| Shah, SS | 1 |
| Evans, P | 1 |
| O'Reilly, D | 1 |
| Flyer, JN | 1 |
| Soll, R | 1 |
| Mitra, S | 1 |
| Khotib, J | 1 |
| Rahmadi, M | 1 |
| Ardianto, C | 1 |
| Nisak, K | 1 |
| Oktavia, R | 1 |
| Ratnasari, A | 1 |
| Dinintia, Y | 1 |
| Shinta, DW | 1 |
| Aryani, T | 1 |
| Dial, EJ | 6 |
| Dawson, PA | 1 |
| Lichtenberger, LM | 5 |
| Amagase, K | 1 |
| Izumi, N | 1 |
| Takahira, Y | 1 |
| Wada, T | 1 |
| Takeuchi, K | 4 |
| Bhattarai, D | 1 |
| Phan, TM | 3 |
| Uray, K | 1 |
| Mayo, SA | 1 |
| Song, YK | 1 |
| Cruz, MR | 1 |
| Singh, KV | 1 |
| Garsin, DA | 1 |
| Murray, BE | 1 |
| Prescott, S | 1 |
| Keim-Malpass, J | 1 |
| Kalani, M | 1 |
| Shariat, M | 1 |
| Khalesi, N | 1 |
| Farahani, Z | 1 |
| Ahmadi, S | 1 |
| Lichtenberger, L | 1 |
| Romero, JJ | 2 |
| Jiang, GL | 1 |
| Im, WB | 1 |
| Donde, Y | 1 |
| Wheeler, LA | 1 |
| Ponce-Monter, H | 1 |
| Fernández-Martínez, E | 1 |
| Ortiz, MI | 1 |
| Ramírez-Montiel, ML | 1 |
| Cruz-Elizalde, D | 1 |
| Pérez-Hernández, N | 1 |
| Cariño-Cortés, R | 1 |
| Lim, YJ | 1 |
| Graham, DY | 1 |
| Takami, T | 1 |
| Yoda, H | 1 |
| Ishida, T | 1 |
| Morichi, S | 1 |
| Kondo, A | 1 |
| Sunohara, D | 1 |
| Hoshika, A | 1 |
| Kawakami, T | 1 |
| Sivanandan, S | 1 |
| Bali, V | 1 |
| Soraisham, AS | 1 |
| Harabor, A | 1 |
| Kamaluddeen, M | 1 |
| Zarza, J | 1 |
| WANKA, J | 1 |
| JONES, LI | 1 |
| WOOD, PH | 1 |
| DIXON, AS | 1 |
| EGELIUS, N | 1 |
| Tanaka, A | 2 |
| Hayashi, Y | 1 |
| Kubo, Y | 1 |
| Dohrman, AJ | 1 |
| Hokama, A | 1 |
| Tanaka, K | 1 |
| Nakamoto, M | 1 |
| Uchima, N | 1 |
| Kinjo, F | 1 |
| Saito, A | 1 |
| Hung, CR | 1 |
| Man, CY | 1 |
| Cheung, IT | 1 |
| Cameron, PA | 1 |
| Rainer, TH | 1 |
| Miura, N | 1 |
| Fukutake, M | 1 |
| Yamamoto, M | 1 |
| Ohtake, N | 1 |
| Iizuka, S | 1 |
| Imamura, S | 1 |
| Tsuchiya, N | 1 |
| Ishimatsu, M | 1 |
| Nakamura, Y | 1 |
| Ishige, A | 1 |
| Watanabe, K | 2 |
| Kase, Y | 1 |
| Takeda, S | 1 |
| Manduch, M | 1 |
| Rossiter, JP | 1 |
| Depew, WT | 1 |
| Mercer, CD | 1 |
| Hurlbut, DJ | 1 |
| Wong, RK | 1 |
| Boedeker, B | 1 |
| Hickey, TM | 1 |
| Wilkinson, DS | 1 |
| Johnson, LF | 1 |
| Hansen, TM | 1 |
| Matzen, P | 1 |
| Madsen, P | 1 |
| van Soesbergen, RM | 1 |
| Posthuma, HS | 1 |
| Domschke, S | 1 |
| Domschke, W | 1 |
| Nagy, G | 1 |
| Szebeni, R | 1 |
| Lanza, FL | 1 |
| Nelson, RS | 1 |
| Greenberg, BP | 1 |
| Konturek, SJ | 1 |
| Kwiecien, N | 1 |
| Obtulowicz, W | 1 |
| Kiec-Dembinska, A | 1 |
| Polanski, M | 1 |
| Kopp, B | 1 |
| Sito, E | 1 |
| Oleksy, J | 1 |
| Hollander, D | 1 |
| Tarnawski, A | 1 |
| Ivey, KJ | 1 |
| DeZeery, A | 1 |
| Zipser, RD | 1 |
| McKenzie, WN | 1 |
| McFarland, WD | 1 |
| Uthgenannt, H | 2 |
| Mohing, W | 1 |
| Köhler, G | 1 |
| Schmidt, F | 1 |
| Havemann, R | 1 |
| Bunton, RW | 1 |
| Barrett, DC | 1 |
| Palmer, DG | 1 |
| Arent, H | 1 |
| Visconti, G | 1 |
| Spotti, D | 1 |
| Piperno, A | 1 |
| Marini, U | 1 |
| Trewby, PN | 1 |
| Ridolfo, AS | 1 |
| Crabtree, RE | 1 |
| Johnson, DW | 1 |
| Rockhold, FW | 1 |
| Yanagi, RM | 1 |
| Wilson, A | 1 |
| Newfeld, EA | 1 |
| Aziz, KU | 1 |
| Hunt, CE | 1 |
| Johansson, C | 2 |
| Kollberg, B | 2 |
| Nordemar, R | 1 |
| Mullett, MD | 1 |
| Croghan, TW | 1 |
| Myerberg, DZ | 1 |
| Krall, JM | 1 |
| Neal, WA | 1 |
| Tepperman, BL | 1 |
| Soper, BD | 1 |
| Warrington, S | 1 |
| Wallace, JL | 3 |
| McKnight, GW | 2 |
| Bell, CJ | 1 |
| Pérez Guerrero, C | 1 |
| Martín, MJ | 1 |
| Marhuenda, E | 1 |
| Jallad, NS | 1 |
| Cattan, A | 1 |
| Weidler, DJ | 1 |
| de Bernardis, E | 1 |
| Caruso, A | 1 |
| Cutuli, VM | 1 |
| Lucenti, A | 1 |
| Villari, L | 1 |
| Amico-Roxas, M | 1 |
| Kaufman, DW | 1 |
| Kelly, JP | 1 |
| Sheehan, JE | 1 |
| Laszlo, A | 1 |
| Wiholm, BE | 1 |
| Alfredsson, L | 1 |
| Koff, RS | 1 |
| Shapiro, S | 1 |
| Melarange, R | 3 |
| Gentry, C | 1 |
| Toseland, CD | 1 |
| Smith, PH | 1 |
| Fuller, J | 1 |
| Gyömber, E | 1 |
| Vattay, P | 1 |
| Szabo, S | 3 |
| Rainsford, KD | 1 |
| Takehara, K | 1 |
| Ohuchi, T | 1 |
| Appleyard, CB | 1 |
| McCafferty, DM | 1 |
| Tigley, AW | 1 |
| Swain, MG | 1 |
| Shindo, M | 1 |
| Majima, M | 1 |
| Ohno, T | 1 |
| Sugimoto, K | 1 |
| Ohwada, T | 1 |
| Murakami, I | 1 |
| Asano, S | 1 |
| Yukishige, K | 1 |
| Nagaya, H | 1 |
| Satoh, H | 2 |
| Inatomi, N | 1 |
| Sato, F | 1 |
| Takami, K | 1 |
| Yamasaki, K | 1 |
| Arakawa, T | 1 |
| Takaishi, O | 1 |
| Higuchi, K | 1 |
| Kobayashi, K | 1 |
| Kuroki, T | 1 |
| Wang, SS | 1 |
| Chu, CJ | 1 |
| Lee, FY | 1 |
| Wu, SL | 1 |
| Lin, HC | 1 |
| Chan, CC | 1 |
| Chang, FY | 1 |
| Lee, SD | 1 |
| Takahashi, S | 1 |
| Fujita, T | 1 |
| Yamamoto, A | 1 |
| Bolisetty, S | 1 |
| Patole, S | 1 |
| Koh, G | 1 |
| Stalewski, H | 1 |
| Whitehall, J | 1 |
| Araki, H | 1 |
| Hase, S | 1 |
| Komoike, Y | 1 |
| Levy, N | 1 |
| Gaspar, E | 1 |
| Menzel, K | 1 |
| Schambach, K | 1 |
| Töpke, B | 1 |
| Menguy, R | 1 |
| Gubler, HU | 1 |
| Baggiolini, M | 1 |
| Ivey, HH | 1 |
| Kattwinkel, J | 1 |
| Park, TS | 1 |
| Krovetz, LJ | 1 |
| Paroli, E | 1 |
| Nencini, P | 1 |
| Anania, MC | 1 |
| Agdal, N | 1 |
| Torgyán, S | 1 |
| Ady, E | 1 |
| Wagner, L | 1 |
| Neumann, T | 1 |
| Béres, G | 1 |
| Csányi, M | 1 |
| Cooke, AR | 2 |
| Cohen, SI | 1 |
| Weintraub, RM | 1 |
| Lehtola, J | 1 |
| Caranasos, GJ | 1 |
| May, FE | 1 |
| Stewart, RB | 1 |
| Cluff, LE | 1 |
| Smyth, RD | 1 |
| Mathur, PP | 1 |
| Procaccini, RL | 1 |
| Carr, GS | 1 |
| Reavey-Cantwell, NH | 1 |
| Beró, T | 1 |
| Nagy, L | 1 |
| Jávor, T | 1 |
| Vincze, A | 1 |
| Lacy, ER | 1 |
| Cowart, KS | 1 |
| Hund, P | 1 |
| Moore, G | 1 |
| Blower, PR | 1 |
| Coates, ME | 1 |
| Ward, FW | 1 |
| Ronaasen, V | 1 |
| Rataboli, PV | 1 |
| Bhandare, PN | 1 |
| D'Souza, RS | 1 |
| Dhume, VG | 1 |
| Arfors, KE | 1 |
| Hakkinen, JP | 1 |
| Holt, WF | 1 |
| Goddard, CJ | 1 |
| Oates, PJ | 1 |
| Murphy, WR | 1 |
| Maciejko, JJ | 1 |
| Reiter, LA | 1 |
| Balint, GA | 1 |
| Whittle, BJ | 1 |
| Lopez-Belmonte, J | 1 |
| Carlan, SJ | 1 |
| Stromquist, C | 1 |
| Angel, JL | 1 |
| Harris, M | 1 |
| O'Brien, WF | 1 |
| Morris, GP | 1 |
| Williamson, TE | 1 |
| Abonyi, S | 1 |
| Hatakeyama, K | 1 |
| Yano, S | 1 |
| Rennie, JM | 1 |
| Cooke, RW | 1 |
| Bhandare, P | 1 |
| Diniz-D'Souza, R | 1 |
| Mainker, A | 1 |
| Dhume, V | 1 |
| Vergin, H | 1 |
| Kori-Lindner, C | 1 |
| Gutiérrez Cabano, CA | 1 |
| Goto, Y | 2 |
| Yamada, M | 2 |
| Ohno, H | 1 |
| Uehara, Y | 1 |
| Gizzi, G | 1 |
| Villani, V | 1 |
| Brandi, G | 1 |
| Paganelli, GM | 1 |
| Di Febo, G | 1 |
| Biasco, G | 1 |
| Rashbrook, LC | 1 |
| Wiesenberg-Böttcher, I | 1 |
| Schweizer, A | 1 |
| Green, JR | 1 |
| Seltenmeyer, Y | 1 |
| Müller, K | 1 |
| Stalnikowicz, R | 1 |
| Goldin, E | 1 |
| Fich, A | 1 |
| Wengrower, D | 1 |
| Eliakim, R | 1 |
| Ligumsky, M | 1 |
| Rachmilewitz, D | 1 |
| Vanhaesebrouck, P | 1 |
| Thiery, M | 1 |
| Leroy, JG | 1 |
| Govaert, P | 1 |
| de Praeter, C | 1 |
| Coppens, M | 1 |
| Cuvelier, C | 1 |
| Dhont, M | 1 |
| Bonney, RJ | 1 |
| Glinka, S | 1 |
| Hopple, S | 1 |
| Bailey, P | 1 |
| Humes, JL | 1 |
| Argenbright, LW | 1 |
| Rogers, C | 1 |
| Brown, A | 1 |
| Warrington, SJ | 1 |
| Dana-Haeri, J | 1 |
| Horton, MA | 1 |
| Thornton, EJ | 1 |
| Bird, HA | 1 |
| Hill, J | 1 |
| Ardley, RG | 1 |
| McEvoy, M | 1 |
| Wright, V | 1 |
| Prichard, PJ | 1 |
| Poniatowska, TJ | 1 |
| Willars, JE | 1 |
| Ravenscroft, AT | 1 |
| Hawkey, CJ | 1 |
| Fujii, A | 1 |
| Kuboyama, N | 1 |
| Kobayashi, S | 1 |
| Namiki, Y | 1 |
| Tamura, T | 1 |
| Giercksky, KE | 1 |
| Suwa, T | 1 |
| Urano, H | 1 |
| Kohno, Y | 1 |
| Suzuki, A | 1 |
| Amano, T | 1 |
| Walinga, H | 1 |
| Hoshina, K | 1 |
| Yamazaki, N | 1 |
| Takeshita, T | 1 |
| Naruchi, T | 1 |
| Chirico, G | 1 |
| Gasparoni, MC | 1 |
| Rondini, G | 1 |
| Casteels-Van Daele, M | 1 |
| Hawkins, C | 1 |
| Bennett, A | 1 |
| Stamford, IF | 1 |
| Unger, WG | 1 |
| Bodin, F | 1 |
| Conte, M | 1 |
| Vasilenko, VKh | 1 |
| Tsodikov, GV | 1 |
| Minushkin, ON | 1 |
| Sun, DC | 1 |
| Nelemans, FA | 1 |
| Ewing, GO | 1 |
| Bennett, PN | 1 |
| Furnemont, E | 1 |
| Komatsu, T | 1 |
| Awata, H | 1 |
| Sakai, Y | 1 |
| Inukai, T | 1 |
| Kimura, M | 1 |
| Inaba, S | 1 |
| Yamamoto, H | 1 |
| Lee, P | 1 |
| Ahola, SJ | 1 |
| Grennan, D | 1 |
| Brooks, P | 1 |
| Buchanan, WW | 1 |
| Dodge, PW | 1 |
| Brodie, DA | 1 |
| Young, PR | 1 |
| Krause, RA | 1 |
| Tekeli, S | 1 |
| Fichera, G | 1 |
| Mirelli, E | 1 |
| Sofia, RD | 1 |
| Diamantis, W | 1 |
| Gordon, R | 1 |
| Kletzkin, M | 1 |
| Berger, FM | 1 |
| Edelson, J | 1 |
| Singer, H | 1 |
| Douglas, JF | 1 |
| Beirne, JA | 1 |
| Bianchine, JR | 1 |
| Johnson, PC | 1 |
| Wortham, GF | 1 |
| Kapp, F | 1 |
| Baerlocher, C | 1 |
| Fahrländer, H | 1 |
| Arnold, L | 1 |
| Collins, C | 1 |
| Starmer, GA | 1 |
| Hodgkinson, R | 1 |
| Woolf, D | 1 |
| Brown, K | 1 |
| Cavalla, JF | 1 |
| Green, D | 1 |
| Wilson, AB | 1 |
| Fischer, I | 1 |
| Rinkoff, S | 1 |
| Julou, L | 1 |
| Ducrot, R | 1 |
| Fournel, J | 1 |
| Ganter, P | 1 |
| Populaire, P | 1 |
| Durel, J | 1 |
| Myon, J | 1 |
| Pascal, S | 1 |
| Pasquet, J | 1 |
| Walz, DT | 1 |
| Di Martino, MJ | 1 |
| Griffin, CL | 1 |
| Misher, A | 1 |
| Jacobsen, CD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study[NCT03103022] | Phase 1 | 20 participants (Actual) | Interventional | 2017-06-12 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for indomethacin and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.
Topics: Cerebral Hemorrhage; Cyclooxygenase Inhibitors; Drug-Related Side Effects and Adverse Reactions; Duc | 2020 |
Indomethacin for symptomatic patent ductus arteriosus in preterm infants.
Topics: Bias; Bronchopulmonary Dysplasia; Cause of Death; Cyclooxygenase Inhibitors; Ductus Arteriosus, Pate | 2021 |
Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options.
Topics: Biomarkers; Cardiac Catheterization; Conservative Treatment; Cyclooxygenase Inhibitors; Ductus Arter | 2017 |
Gastroduodenal damage due to drugs, alcohol and smoking.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Aspirin; Ethanol; Gastric Mucosa; Gastrointestinal | 1984 |
Use of Rimazolium in locomotor diseases.
Topics: Analgesics; Arthritis; Arthritis, Rheumatoid; Chemical Phenomena; Chemistry; Drug Therapy, Combinati | 1983 |
[The most common drugs considered harmful to the stomach, Clinical and endoscopic studies].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents; Aspirin; Dyspepsia; Fema | 1980 |
Drug-induced peptic ulcer and upper gastrointestinal bleeding.
Topics: Adrenal Cortex Hormones; Alcoholism; Animals; Aspirin; Diuretics; Emepronium; Female; Gastrointestin | 1980 |
Effects of piroxicam-beta-cyclodextrin on the gastrointestinal tract.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Controlled | 1993 |
[The patent ductus arteriosus from a perinatological viewpoint].
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Fetus; Gastrointestinal Hemorrhage; Growth; Hu | 1978 |
The role of the mucosal barrier in drug-induced gastric ulceration and erosions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Ethanol; Gastric Juice; Gastric Mucosa; | 1976 |
Oligohydramnios, renal insufficiency, and ileal perforation in preterm infants after intrauterine exposure to indomethacin.
Topics: Amniotic Fluid; Female; Gastrointestinal Hemorrhage; Humans; Ileal Diseases; Indomethacin; Infant, L | 1988 |
[Effect of some antirheumatic agents on the gastric mucous membrane].
Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheuma | 1971 |
21 trials available for indomethacin and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
A Comparison of Early Ibuprofen and Indomethacin Administration to Prevent Intraventricular Hemorrhage Among Preterm Infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorrhage; Cyclooxygenase Inhibitors; Ductus Arte | 2016 |
Comparison of oral prednisolone/paracetamol and oral indomethacin/paracetamol combination therapy in the treatment of acute goutlike arthritis: a double-blind, randomized, controlled trial.
Topics: Abdominal Pain; Acetaminophen; Acute Disease; Administration, Oral; Aged; Aged, 80 and over; Analges | 2007 |
Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation.
Topics: Adult; Anti-Inflammatory Agents; Capsules; Drug Evaluation; Female; Gastric Mucosa; Gastrointestinal | 1983 |
Effect of carprofen and indomethacin on gastric function, mucosal integrity and generation of prostaglandins in men.
Topics: Adult; Anti-Inflammatory Agents; Blood Circulation; Carbazoles; Clinical Trials as Topic; Dinoprosto | 1982 |
[The influence of acemetacin and indometacin on gastrointestinal blood loss in normal volunteers and rheumatic patients (author's transl)].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Double-Blind Method; Gastrointestinal | 1980 |
[Effect of 3-(4-chlorphenyl-) 1-phenyl-1H-pyrazole-4-acetic acid (lonazolac-Ca), diclofenac-Na and indomethacin on the gastrointestinal blood loss].
Topics: Anti-Inflammatory Agents; Diclofenac; Digestive System; Gastrointestinal Hemorrhage; Humans; Indomet | 1982 |
Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Clinical Trials as Topic; Do | 1980 |
Indomethacin treatment for symptomatic patent ductus arteriosus: a double-blind control study.
Topics: Clinical Trials as Topic; Double-Blind Method; Ductus Arteriosus, Patent; Gastrointestinal Hemorrhag | 1981 |
Clinical trials with prostaglandin E2.
Topics: Arthritis; Arthritis, Rheumatoid; Clinical Trials as Topic; Dinoprostone; Double-Blind Method; Gastr | 1981 |
Gastrointestinal protection by low-dose oral prostaglandin E2 in rheumatic diseases.
Topics: Administration, Oral; Adult; Clinical Trials as Topic; Gastrointestinal Hemorrhage; Humans; Indometh | 1981 |
Indomethacin for closure of patent ductus arteriosus in prematures.
Topics: Clinical Trials as Topic; Double-Blind Method; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembr | 1982 |
Efficacy of misoprostol in controlling indomethacin induced fecal blood loss in arthritic patients.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Female; Gastrointestinal Hemorrhage; Humans; Indomethaci | 1993 |
Nonsteroidal anti-inflammatory drug use in relation to major upper gastrointestinal bleeding.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Dic | 1993 |
Reduction of indomethacin-induced gastrointestinal blood loss by sodium salicylate in man.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Humans; Indomethacin; Ma | 1978 |
Effect of indomethacin and phenylbutazone-prednisone combination of gastric mucosa: gastroscopic and histological study.
Topics: Biopsy; Drug Combinations; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Indomet | 1975 |
Prolonged low dose indomethacin for persistent ductus arteriosus of prematurity.
Topics: Ductus Arteriosus, Patent; Gastrointestinal Hemorrhage; Humans; Indomethacin; Infant, Newborn; Recur | 1991 |
Indomethacin-induced gastroduodenal damage is not affected by cotreatment with ranitidine.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Drug Synergism; Duodenal Diseases; Duodenum; Female; G | 1989 |
Comparison of gastrointestinal blood loss in healthy male volunteers during repeated administration of standard and sustained action tiaprofenic acid and sustained release indomethacin.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromium Radioisotopes; Delayed-Action P | 1988 |
A comparison of blood loss caused by two prolonged-release formulations of indomethacin ('Flexin Continus' and 'Indocid' R) in normal healthy male volunteers.
Topics: Adult; Delayed-Action Preparations; Double-Blind Method; Gastrointestinal Hemorrhage; Humans; Indome | 1988 |
Effect in man of aspirin, standard indomethacin, and sustained release indomethacin preparations on gastric bleeding.
Topics: Adolescent; Adult; Aspirin; Delayed-Action Preparations; Female; Gastric Acid; Gastrointestinal Hemo | 1988 |
A five-year clinical trial of indomethacin in osteoarthrosis of the hip.
Topics: Aged; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Hip Joint; Humans; Indomethacin | 1973 |
105 other studies available for indomethacin and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzoxepins; Edema; Gastrointestinal Hemorrhage; Male | 1986 |
Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyc | 2000 |
Solid Nanocrystals of Rebamipide Promote Recovery from Indomethacin-Induced Gastrointestinal Bleeding.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Hemorrhage; Indomethacin | 2019 |
Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Fluvoxa | 2019 |
In vitro evidence that phosphatidylcholine protects against indomethacin/bile acid-induced injury to cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts; Cell Membrane; Gastrointesti | 2015 |
Importance of cyclooxygenase-1/prostacyclin in modulating gastric mucosal integrity under stress conditions.
Topics: Animals; Cold Temperature; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Epoprostenol; | 2014 |
Suppression of contractile activity in the small intestine by indomethacin and omeprazole.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Enteritis; Gastrointestinal Hemorrhage | 2015 |
Indomethacin injury to the rat small intestine is dependent upon biliary secretion and is associated with overgrowth of enterococci.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Translocation; Bile; Bile Ducts; Disease | 2016 |
Gastrointestinal safety and therapeutic efficacy of parenterally administered phosphatidylcholine-associated indomethacin in rodent model systems.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Dinoprostone | 2009 |
EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose | 2009 |
Spasmolytic and anti-inflammatory effects of Aloysia triphylla and citral, in vitro and in vivo studies.
Topics: Acyclic Monoterpenes; Animals; Anti-Inflammatory Agents; Dinoprost; Female; Gastrointestinal Hemorrh | 2010 |
In vitro and in vivo protection against indomethacin-induced small intestinal injury by proton pump inhibitors, acid pump antagonists, or indomethacin-phosphatidylcholine.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis | 2012 |
Effects of indomethacin on patent ductus arteriosus in neonates with genetic disorders and/or congenital anomalies.
Topics: Chromosomes, Human, Pair 18; Cyclooxygenase Inhibitors; Down Syndrome; Ductus Arteriosus, Patent; Ga | 2013 |
Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Fema | 2013 |
Major bleeding during combined treatment with indomethacin and low doses of acenocoumarol in a homozygous patient for 2C9*3 variant of cytochrome p-450 CYP2C9.
Topics: Acenocoumarol; Aged; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Cytochrome P-450 CYP2C9; Drug I | 2003 |
INDOMETHACIN IN RHEUMATIC DISEASES. A CONTROLLED CLINICAL TRIAL.
Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Biomedical Research; Drug Hypersensitivity; Gastrointesti | 1964 |
INDOMETHACIN: A NEW ANTI-RHEUMATIC DRUG.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Antirheumatic Agents; Arthritis; Arthritis, Rheu | 1965 |
Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility.
Topics: Animals; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinopro | 2004 |
Recombinant human lactoferrin prevents NSAID-induced intestinal bleeding in rodents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Gastrointestinal Hemorrhage; Humans; I | 2005 |
An unusual cause of rectal bleeding in a patient with rheumatoid arthritis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Colonic Diseases; Female; Gast | 2005 |
Modulation of gastric hemorrhage and ulceration by oxidative stress and histamine release in Salmonella typhimurium-infected rats.
Topics: Allopurinol; Animals; Antioxidants; Dimethyl Sulfoxide; Disease Models, Animal; Gastric Juice; Gastr | 2005 |
An herbal medicine orengedokuto prevents indomethacin-induced enteropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Re | 2007 |
Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aortic Diseases; Fatal Outcome; Fundoplication; Gastric Fis | 2008 |
Lithium chloride: protective and antisecretory properties in rats.
Topics: Animals; Chlorides; Dinoprostone; Disease Models, Animal; Drug Evaluation; Ethanol; Gastric Acid; Ga | 1984 |
Endoscopic evaluation of the effect of indomethacin capsules and suppositories on the gastric mucosa in rheumatic patients.
Topics: Adult; Aged; Capsules; Double-Blind Method; Drug Evaluation; Endoscopy; Female; Gastric Acid; Gastri | 1984 |
[Hemorrhage of the small intestine caused by indomethacin (Indosmos)?].
Topics: Aged; Arthritis, Rheumatoid; Female; Gastrointestinal Hemorrhage; Humans; Ileal Diseases; Indomethac | 1984 |
Patent ductus arteriosus in premature babies.
Topics: Administration, Oral; Ductus Arteriosus, Patent; Female; Gastrointestinal Hemorrhage; Humans; Indome | 1982 |
Arachidonic acid protection of rat gastric mucosa against ethanol injury.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Ethanol; Gastric Mucosa; Gastrointestina | 1982 |
Reintroduction of anti-inflammatory drug therapy after drug-associated gastro-intestinal disturbances.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Arthritis; Duodenal Ulcer; Female; Gastrointes | 1982 |
Interaction of nitric oxide and salivary gland epidermal growth factor in the modulation of rat gastric mucosal integrity.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Epidermal Growth Factor; Gastric Muco | 1993 |
Adaptation of rat gastric mucosa to aspirin requires mucosal contact.
Topics: Adaptation, Physiological; Animals; Aspirin; Dinoprostone; Gastric Mucosa; Gastritis; Gastrointestin | 1995 |
Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins.
Topics: Animals; Edema; Ethanol; Gastric Mucosa; Gastrointestinal Hemorrhage; Indomethacin; Male; Prostaglan | 1994 |
Effects of GABAergic drugs on ethanol-induced gastric lesions.
Topics: Animals; Baclofen; Bicuculline; Diazepam; Ethanol; GABA Antagonists; gamma-Aminobutyric Acid; Gastro | 1993 |
Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antilymphocyte Serum; Etodolac; Gastric Mucosa; Ga | 1995 |
Role of early vascular damage in the pathogenesis of gastric haemorrhagic mucosal lesions induced by indomethacin in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Female; Gastr | 1996 |
Diethyldithiocarbamate, a superoxide dismutase inhibitor, reduces indomethacin-induced gastric lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Chelating Agents; Ditiocar | 1996 |
Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Movement; Gastroi | 1996 |
Induction mechanism of small intestinal lesions caused by intravenous injection of endotoxin in rats.
Topics: Animals; Capillary Leak Syndrome; Cyclooxygenase Inhibitors; Endotoxins; Enzyme Inhibitors; Epoprost | 1996 |
[Effects of lansoprazole on indomethacin-induced gastric bleeding and mucosal lesions in rats].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Dru | 1996 |
New ulcerative colitis model induced by sulfhydryl blockers in rats and the effects of antiinflammatory drugs on the colitis.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Colitis, | 1997 |
Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress.
Topics: Acute Disease; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalas | 1999 |
Effects of prostacyclin inhibition on splanchnic hyposensitivity to glypressin in a hemorrhage-transfused rat model of portal hypertension.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Transfusion; Cyclooxygenase Inhibitors | 2000 |
Role of cyclooxygenase-2 in Helicobacter pylori- induced gastritis in Mongolian gerbils.
Topics: Animals; Chemokines; Chemotactic Factors; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhib | 2000 |
Neonatal acute haemorrhagic gastritis and antenatal exposure to indomethacin for tocolysis.
Topics: Adolescent; Fatal Outcome; Female; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Humans; I | 2001 |
Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury.
Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygen | 2002 |
Letter: Rectal bleeding and indomethacin suppositories.
Topics: Adolescent; Arthritis, Rheumatoid; Gastrointestinal Hemorrhage; Humans; Indomethacin; Male; Rectal D | 1975 |
Gastric mucosal injury from common drugs.
Topics: Adrenal Cortex Hormones; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; G | 1978 |
Pharmacological properties of proquazone.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1978 |
Failure of indomethacin to close persistent ductus arteriosus in infants weighing under 1000 grams.
Topics: Anuria; Digitalis Glycosides; Ductus Arteriosus, Patent; Female; Gastrointestinal Hemorrhage; Heart | 1979 |
Correlations of DNA, RNA and protein levels in duodenal mucosa with antiinflammatory potency and disposition to gut damage of non-steroidal agents. Comparative behaviour of glucametacine, indometacin, phenylbutazone and ibuprofen.
Topics: Animals; Anti-Inflammatory Agents; DNA; Duodenal Ulcer; Duodenum; Female; Gastrointestinal Hemorrhag | 1978 |
[Drug-induced esophageal damage. Review and report of a fatal case of indomethacin-induced ulceration].
Topics: Aged; Esophageal Diseases; Female; Gastrointestinal Hemorrhage; Humans; Indomethacin; Ulcer | 1979 |
A new application of counterpulsation: safer laparotomy after recent myocardial infarction.
Topics: Angiography; Assisted Circulation; Blood Pressure; Cardiac Output; Gastrointestinal Hemorrhage; Hemo | 1975 |
Drug-associated deaths of medical inpatients.
Topics: Adolescent; Adult; Aged; Aspirin; Azathioprine; Drug Therapy; Female; Florida; Gastrointestinal Hemo | 1976 |
Comparative effects of fenclorac and indomethacin on gastrointestinal blood loss in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Erythrocyte Agin | 1976 |
Gastric damage by drugs and the role of the mucosal barrier.
Topics: Animals; Aspirin; Dogs; Ethanol; Gastric Mucins; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans | 1976 |
Measurement of non-steroid antiinflammatory drugs induced gastric microbleeding.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Diclofenac; Gastric Juice; Gastrointestinal | 1992 |
Effects of chronic superficial injury on the rat gastric mucosa.
Topics: Animals; Dinoprostone; Gastric Mucosa; Gastrointestinal Hemorrhage; Indomethacin; Irritants; Male; R | 1992 |
A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats.
Topics: Animals; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Germ-Free Life; Ibuprofen; Indomethaci | 1992 |
Protective effect of propranolol on ethanol-induced gastric lesions in rats: probable mechanism of action.
Topics: Animals; Drug Interactions; Ethanol; Gastric Fundus; Gastrointestinal Hemorrhage; Indomethacin; Lido | 1992 |
A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Surface; CD18 Antigens; Cell Adhesion; Endo | 1991 |
CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties.
Topics: Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; Gastric Mucosa; | 1991 |
Possibilities to reduce the unwanted gastric side-effects of orally administered indomethacin in the rat.
Topics: Administration, Oral; Animals; Cysteine; Epoprostenol; Female; Gastrointestinal Hemorrhage; Indometh | 1991 |
Interactions between the vascular peptide endothelin-1 and sensory neuropeptides in gastric mucosal injury.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Endothelins; Gastric Mucosa; Gastrointestinal H | 1991 |
Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding.
Topics: Adult; Anuria; Cocaine; Drug Synergism; Female; Fetal Diseases; Gastrointestinal Hemorrhage; Humans; | 1991 |
The effects of sucralfate and luminal stasis on recovery of the chambered rat gastric mucosa from taurocholate-induced damage.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Ga | 1991 |
Gastric bleeding and increased gastric vascular permeability induced by platelet activating factor (PAF): effect of drugs that affect arachidonate metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caffeic Acids; Capillary Permeability; Dinoprostone; G | 1991 |
Protective effect of propranolol on ethanol-induced gastric lesions in mice.
Topics: Administration, Oral; Animals; Ethanol; Gastrointestinal Hemorrhage; Indomethacin; Injections, Intra | 1990 |
Putative mechanisms of cytoprotective effect of certain antacids and sucralfate.
Topics: Aluminum Hydroxide; Animals; Antacids; Dinoprostone; Dose-Response Relationship, Drug; Ethanol; Gast | 1990 |
[Gastric lesions induced by ethanol and indomethacin: cytoprotective effect of acetazolamide].
Topics: Acetazolamide; Animals; Bicarbonates; Drug Therapy, Combination; Ethanol; Female; Gastric Acid; Gast | 1990 |
[Quantitative assessment of gastric mucosal bleeding in the development of acute gastric mucosal lesions in the rat and prophylactic effect of elcatonin].
Topics: Animals; Calcitonin; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Gastrointestina | 1990 |
Ano-rectal lesions in patients taking suppositories containing non-steroidal anti-inflammatory drugs (NSAID).
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anus Diseases; Diclofenac; Endoscopy; Female; Gastro | 1990 |
Comparison of the effects of nabumetone with indomethacin on rat gastric mucosal 6-keto-PGF1 alpha production and on bile salt-induced changes in gastric mucosal function.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile Acids and Salts | 1987 |
Quantitative assessment of mild stages of experimental gastritis in the rat and the effects of several types of antiulcer drugs.
Topics: Animals; Anti-Ulcer Agents; Gastritis; Gastrointestinal Hemorrhage; Indomethacin; Male; Rats; Rats, | 1989 |
The pharmacological profile of CGP 28238, a highly potent anti-inflammatory compound.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Gastrointestinal H | 1989 |
Assessment of gastric bleeding in rats: effects of cyclooxygenase inhibitors and 16,16-dimethyl prostaglandin E2 on gastric bleeding.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Cyclooxygenase Inhibitors; Gastrointestinal Hemorrhage; Ind | 1987 |
Gastric mucosal protection by new aryl sulfhydryl drugs.
Topics: Animals; Aspirin; Chronic Disease; Dose-Response Relationship, Drug; Ethanol; Ethylmaleimide; Female | 1988 |
Time-course study of gastric damages in rats by anti-inflammatory drugs using a gastroscope and its quantification.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Fenoprofen; Gastric Mucosa; Gastrointesti | 1988 |
Piroxicam and gastrointestinal bleeding.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Drug Utilization; Female; Gastrointestinal Hemorrhage; Hosp | 1986 |
Comparative studies on the gastrointestinal lesions caused by several nonsteroidal anti-inflammatory agents in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Feces; Gastric Muco | 1987 |
[Hemorrhages of the small intestines caused by indomethacin (Indosmos)?].
Topics: Gastrointestinal Hemorrhage; Humans; Indomethacin; Intestine, Small | 1985 |
Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103).
Topics: Acetates; Acetic Acid; Aminopyrine; Animals; Anti-Ulcer Agents; Aspirin; Bethanechol Compounds; Cime | 1985 |
Exchange transfusion for indomethacin-induced hemorrhagic complication in the neonate.
Topics: Exchange Transfusion, Whole Blood; Female; Gastrointestinal Hemorrhage; Humans; Indomethacin; Infant | 1985 |
Anti-inflammatory drugs and bowel perforations and haemorrhage.
Topics: Adult; Gastrointestinal Hemorrhage; Humans; Indomethacin; Intestinal Perforation; Intestine, Small; | 1985 |
Gastrointestinal bleeding: a possible association with ibuprofen.
Topics: Acetaminophen; Aminopyrine; Analgesics; Anti-Inflammatory Agents; Aspirin; Benzyl Compounds; Child; | 1972 |
Pain in haemophilia.
Topics: Aspirin; Gastrointestinal Hemorrhage; Hemophilia A; Humans; Indomethacin; Male; Pain; Phenylbutazone | 1973 |
Prostaglandin E2 and gastric acid secretion in man.
Topics: Gastric Juice; Gastric Mucosa; Gastrointestinal Hemorrhage; Histamine; Humans; Indomethacin; Intesti | 1973 |
[Digestive tract hemorrhages following ingestion of anti-inflammatory drugs].
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents; Duodenal Ulcer; Female; Gastrointestinal He | 1969 |
Iatrogenic gastrointestinal diseases in the aged.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aged; Cathartics; Chemical and Drug Induced Li | 1972 |
[Analgesics in dentistry].
Topics: Acetanilides; Agranulocytosis; Analgesics; Anesthesia, Dental; Aspirin; Blood Coagulation; Caffeine; | 1972 |
Indomethacin-associated gastrointestinal hemorrhage in a dog.
Topics: Administration, Oral; Animals; Dog Diseases; Dogs; Duodenal Diseases; Female; Gastritis; Gastrointes | 1972 |
Gastric mucosal damage by anti-inflammatory drugs.
Topics: Absorption; Anti-Inflammatory Agents; Aspirin; Diffusion; Gastric Mucins; Gastric Mucosa; Gastritis; | 1972 |
[Ulcers of the gastroduodenal tract due to drugs. Apropos of a personal experience].
Topics: Adrenal Cortex Hormones; Adult; Aged; Analgesics; Aspirin; Duodenal Ulcer; Female; Gastrointestinal | 1972 |
Synthesis and pharmacology of a novel anti-inflammatory agent, ID-1619.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Capillary Permeability; Chemical Phenomena | 1972 |
Observations on drug prescribing in rheumatoid arthritis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Drug Prescriptions | 1974 |
Prevention of antiinflammatory drug-induced gastric lesions in rats by Abbott-29590.
Topics: Analgesics; Animals; Aspirin; Dose-Response Relationship, Drug; Drug Interactions; Gastric Juice; Ga | 1974 |
[Gastro-duodenal tolerance of some drugs with analgesic effect. Clinico-endoscopic considerations].
Topics: Analgesics; Anti-Inflammatory Agents; Antimalarials; Aspirin; Digestive System; Duodenal Ulcer; Esop | 1974 |
Pharmacology of a new non-steroidal anti-inflammatory agent 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one (W-2395).
Topics: Adjuvants, Immunologic; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Benzoxazi | 1974 |
Gastrointestinal blood loss caused by tolmetin, aspirin, and indomethacin.
Topics: Adult; Anti-Inflammatory Agents; Aspirin; Benzoates; Chromium Radioisotopes; Diet; Female; Gastroint | 1974 |
[Drugs and gastric hemorrhage. Results of 1 year's prospective study].
Topics: Alcoholic Beverages; Anticoagulants; Blood Transfusion; Cortisone; Drug Therapy, Combination; Gastro | 1974 |
Renal and gastric lesions after phenylbutazone and indomethacin in the rat.
Topics: Animals; Ascites; Epithelium; Female; Gastrointestinal Hemorrhage; Indomethacin; Kidney; Kidney Papi | 1974 |
Diaryloxazole and diarylthiazolealkanoic acids: two novel series of non-steroidal anti-inflammatory agents.
Topics: Aldehydes; Animals; Anti-Inflammatory Agents; Aspirin; Biological Assay; Carrageenan; Edema; Gastric | 1968 |
Gastrointestinal hemorrhage caused by indomethacin.
Topics: Gastrointestinal Hemorrhage; Humans; Indomethacin; Male; Melena; Middle Aged; Osteoarthropathy, Prim | 1969 |
[Toxicologic study of methiazinic acid (16091 R.P)].
Topics: Abnormalities, Drug-Induced; Acetates; Anemia; Animals; Dogs; Drug Tolerance; Female; Gastric Mucosa | 1969 |
Investigation of the carrageenin-induced rat paw edema assay and correlation between anti-inflammatory activity and gastric hemorrhage production in the rat.
Topics: Adrenalectomy; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Croton Oil; Edem | 1970 |
[Drug-induced anemias].
Topics: Adrenal Cortex Hormones; Anemia; Barbiturates; Bone Marrow; Chloramphenicol; Chlorpromazine; Dihydro | 1970 |