Page last updated: 2024-10-29

indomethacin and Gastroesophageal Reflux

indomethacin has been researched along with Gastroesophageal Reflux in 5 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.

Research Excerpts

ExcerptRelevanceReference
"In this rat model of gastrointestinal reflux, indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma."3.78Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ( Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2012)
"Acute gastrointestinal hemorrhage from a gastroaortic fistula in the gastric fundoplication pouch is a rare complication of Nissen fundoplication."1.35Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use. ( Depew, WT; Hurlbut, DJ; Manduch, M; Mercer, CD; Rossiter, JP, 2008)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dutta, S1
Singh, B1
Chessell, L1
Wilson, J1
Janes, M1
McDonald, K1
Shahid, S1
Gardner, VA1
Hjartarson, A1
Purcha, M1
Watson, J1
de Boer, C1
Gaal, B1
Fusch, C1
Esquivias, P1
Morandeira, A1
Escartín, A1
Cebrián, C1
Santander, S1
Esteva, F1
García-González, MA1
Ortego, J1
Lanas, A1
Piazuelo, E1
Manduch, M1
Rossiter, JP1
Depew, WT1
Mercer, CD1
Hurlbut, DJ1
Dyck, WP1
Dilawari, JB1
Newman, A1
Poleo, J1
Misiewicz, JJ1

Reviews

1 review available for indomethacin and Gastroesophageal Reflux

ArticleYear
Guidelines for feeding very low birth weight infants.
    Nutrients, 2015, Jan-08, Volume: 7, Issue:1

    Topics: Breast Feeding; Canada; Enema; Enteral Nutrition; Fetal Blood; Food, Fortified; Gastroesophageal Ref

2015

Other Studies

4 other studies available for indomethacin and Gastroesophageal Reflux

ArticleYear
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
    World journal of gastroenterology, 2012, Sep-21, Volume: 18, Issue:35

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic

2012
Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use.
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2008, Volume: 22, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aortic Diseases; Fatal Outcome; Fundoplication; Gastric Fis

2008
Pathophysiologic considerations in peptic ulcer disease.
    Southern medical journal, 1979, Volume: 72, Issue:3

    Topics: ABO Blood-Group System; Adrenal Cortex Hormones; Aspirin; Bicarbonates; Environment; Female; Gastric

1979
Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.
    Gut, 1975, Volume: 16, Issue:2

    Topics: Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Esophagogastric Junction; Esophagus; Gas

1975