indomethacin has been researched along with Gastroesophageal Reflux in 5 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this rat model of gastrointestinal reflux, indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma." | 3.78 | Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ( Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2012) |
| "Acute gastrointestinal hemorrhage from a gastroaortic fistula in the gastric fundoplication pouch is a rare complication of Nissen fundoplication." | 1.35 | Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use. ( Depew, WT; Hurlbut, DJ; Manduch, M; Mercer, CD; Rossiter, JP, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dutta, S | 1 |
| Singh, B | 1 |
| Chessell, L | 1 |
| Wilson, J | 1 |
| Janes, M | 1 |
| McDonald, K | 1 |
| Shahid, S | 1 |
| Gardner, VA | 1 |
| Hjartarson, A | 1 |
| Purcha, M | 1 |
| Watson, J | 1 |
| de Boer, C | 1 |
| Gaal, B | 1 |
| Fusch, C | 1 |
| Esquivias, P | 1 |
| Morandeira, A | 1 |
| Escartín, A | 1 |
| Cebrián, C | 1 |
| Santander, S | 1 |
| Esteva, F | 1 |
| García-González, MA | 1 |
| Ortego, J | 1 |
| Lanas, A | 1 |
| Piazuelo, E | 1 |
| Manduch, M | 1 |
| Rossiter, JP | 1 |
| Depew, WT | 1 |
| Mercer, CD | 1 |
| Hurlbut, DJ | 1 |
| Dyck, WP | 1 |
| Dilawari, JB | 1 |
| Newman, A | 1 |
| Poleo, J | 1 |
| Misiewicz, JJ | 1 |
1 review available for indomethacin and Gastroesophageal Reflux
| Article | Year |
|---|---|
Guidelines for feeding very low birth weight infants.
Topics: Breast Feeding; Canada; Enema; Enteral Nutrition; Fetal Blood; Food, Fortified; Gastroesophageal Ref | 2015 |
4 other studies available for indomethacin and Gastroesophageal Reflux
| Article | Year |
|---|---|
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic | 2012 |
Fatal hemorrhage from a gastroaortic fistula secondary to gastric ulceration associated with Nissen fundoplication and nonsteroidal anti-inflammatory drug use.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aortic Diseases; Fatal Outcome; Fundoplication; Gastric Fis | 2008 |
Pathophysiologic considerations in peptic ulcer disease.
Topics: ABO Blood-Group System; Adrenal Cortex Hormones; Aspirin; Bicarbonates; Environment; Female; Gastric | 1979 |
Response of the human cardia sphincter to circulating prostaglandins F2ALPHA and E2 and to antiinflammatory drugs.
Topics: Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Esophagogastric Junction; Esophagus; Gas | 1975 |