indomethacin has been researched along with Gastric Diseases in 120 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers." | 7.75 | EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009) |
| "In the present work it was determined the ability of non-steroidal anti-inflammatory drugs (Diflunisal and Indomethacin) to inhibit formation of "granuloma pouch" exudate induced in rats." | 7.66 | ["Granuloma pouch" reduction after treatment with indomethacin and diflunisal and collateral effects of these drugs on gastric mucosa]. ( Alesse, E; Bruno, G; Cifone, MG; Conti, P; Continenza, MA, 1980) |
| "In this work the authors are concerned with the study of different amounts of calcium in granulomas induced by permanganate and treated with Indomethacin only or with Indomethacin plus Diflunisal." | 7.66 | [Calcium content of KMnO4 induced granuloma after treatment with 2 combined non-steroidal drugs: indomethacin plus diflunisal]. ( Conti, P; Continenza, MA; Gigante, GE, 1980) |
| "Primary dysmenorrhea is a difficult entity to treat, and therapy is usually directed at relieving symptoms." | 6.65 | Primary dysmenorrhea treated with indomethacin. ( Jennings, JC; Morrison, JC, 1979) |
| " The gastroprotective activity of the OECC was investigated using animal models of gastric ulcer induced by the administration of absolute ethanol, acidified ethanol or indomethacin." | 3.85 | Gastroprotective effect and mechanism of action of Croton rhamnifolioides essential oil in mice. ( Coutinho, HDM; da Silva Almeida, JRG; de Albuquerque, TR; de Alencar Silva, A; de Menezes, IRA; de Oliveira, MRC; Oliveira Brito Pereira Bezerra Martins, A; Quintans, LJ; Ribeiro-Filho, J; Vidal, CS, 2017) |
| " The gastroprotective effect of HAE was demonstrated on the indomethacin-induced gastric ulcer model after the administration of extracts." | 3.79 | Protective effect of Chresta martii extract against indomethacin-induced gastric lesions in mice. ( Abbet, C; Aguiar, JA; Bezerra, MM; Chaves, HV; Franco, ES; Henriques, AT; Hostettmann, K; Maia, MB; Pereira, KM; Pinto, VP; Silva, AA; Simões-Pires, CA, 2013) |
| " Groups (N = 6-8) were submitted to right or left paw edema (PE) with carrageenan (100 microg) or Dextran (200 microg), hemorrhagic cystitis with ifosfamide (200 mg/kg, ip) or gastric injury (GI) with indomethacin (20 mg/kg, vo)." | 3.75 | Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats. ( Gomes, AS; Loiola, RT; Ribeiro, RA; Rocha, EL; Simão, AF; Souza Filho, MV; Souza, MH, 2009) |
| "To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers." | 3.75 | EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing. ( Donde, Y; Im, WB; Jiang, GL; Wheeler, LA, 2009) |
| " Three models of acute gastric damage (ethanol, hemorrhagic shock, and indomethacin) were examined and treatment was also carried out with the antiulcer drugs omeprazole, ranitidine, and misoprostol, to show the advantages of this histomorphometric approach." | 3.71 | Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage. ( Blandizzi, C; Del Tacca, M; Gherardi, G; Lazzeri, G; Lenzi, P; Natale, G; Pellegrini, A, 2001) |
| "Examination of gastric secretion in rheumatoid arthritis (RA) patients and its response to sodium diclophenak and indomethacine." | 3.70 | [Approaches to prediction of gastropathy development risk due to non-steroidal antiinflammatory drugs]. ( Alekseeva, AV; Murav'ev, IuV, 2000) |
| ") on susceptibility to gastrointestinal damage induced by hemorrhagic shock, stress, platelet-activating factor (PAF), indomethacin or endotoxin." | 3.68 | Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress and PAF in the rat. ( Boichot, E; Brecx, A; Paubert-Braquet, M; Sidoti, C; Wallace, JL, 1993) |
| "A combination of indomethacin and diflunisal, a new salicylic acid derivative, when given to rats, gave a greater reduction in the size of permanganate induced granulomas and less gastric irritation, than either drug given alone." | 3.66 | Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal. ( Conti, P; Continenza, A, 1980) |
| "In this work the authors are concerned with the study of different amounts of calcium in granulomas induced by permanganate and treated with Indomethacin only or with Indomethacin plus Diflunisal." | 3.66 | [Calcium content of KMnO4 induced granuloma after treatment with 2 combined non-steroidal drugs: indomethacin plus diflunisal]. ( Conti, P; Continenza, MA; Gigante, GE, 1980) |
| "In the present work it was determined the ability of non-steroidal anti-inflammatory drugs (Diflunisal and Indomethacin) to inhibit formation of "granuloma pouch" exudate induced in rats." | 3.66 | ["Granuloma pouch" reduction after treatment with indomethacin and diflunisal and collateral effects of these drugs on gastric mucosa]. ( Alesse, E; Bruno, G; Cifone, MG; Conti, P; Continenza, MA, 1980) |
| "Primary dysmenorrhea is a difficult entity to treat, and therapy is usually directed at relieving symptoms." | 2.65 | Primary dysmenorrhea treated with indomethacin. ( Jennings, JC; Morrison, JC, 1979) |
| "Eighteen patients with definite ankylosing spondylitis were treated with 3 to 4 g." | 2.64 | Alclofenac in ankylosing spondylitis. ( Bulgen, DY; Hazleman, BL, 1975) |
| "Indomethacin is a nonsteroid anti-inflammatory drug (NSAID) that is used to alleviate pain and inflammation in clinical medicine." | 1.46 | Apple Polyphenol Suppresses Indomethacin-Induced Gastric Damage in Experimental Animals by Lowering Oxidative Stress Status and Modulating the MAPK Signaling Pathway. ( Cheng, CW; Chu, HC; Lee, HJ; Lee, YC, 2017) |
| "When indomethacin (3 mg/kg) was administered after a morning meal (fed condition) for 7 days, it produced many lesions in the small intestine." | 1.43 | Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs. ( Idaka, S; Ishigami, K; Kondo, R; Satoh, H; Shinoda, T; Shiotani, S, 2016) |
| "Indomethacin cytotoxicity was determined by lactate dehydrogenase release from murine gastric epithelial GSM06 cells induced by 24-h treatment with 200 and 400 μM indomethacin after 1-h preincubation with 100 μg/ml sake yeast-derived thioredoxin." | 1.38 | Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin. ( Fukui, T; Kishimoto, M; Nakajima, A; Nakayama, S; Nishio, A; Okazaki, K; Sakaguchi, Y; Takahashi, Y; Uchida, K; Yamashina, M; Yodoi, J; Yoshida, K, 2012) |
| "Indomethacin-treated mice developed weight loss and melena." | 1.33 | Effects of esomeprazole magnesium on nonsteroidal anti-inflammatory drug gastropathy. ( Darrabie, M; Koch, TR; Opara, EC; Petro, A, 2005) |
| "Indomethacin treatment dose-dependently reduced survivin protein levels and caused severe injury of gastric mucosa and RGM-1 cells." | 1.33 | Survivin: a novel target for indomethacin-induced gastric injury. ( Abdelkarim, B; Akahoshi, T; Chiou, SK; Jones, MK; Tanigawa, T; Tarnawski, AS, 2005) |
| "pretreatment with indomethacin." | 1.32 | Ghrelin-a new gastroprotective factor in gastric mucosa. ( Brzozowski, T; Drozdowicz, D; Hahn, EG; Harsch, I; Konturek, PC; Konturek, SJ; Kwiecien, S; Nikiforuk, A; Pajdo, R, 2004) |
| "metronidazole pretreatment." | 1.30 | The vascular and glandular organoprotective properties of metronidazole in the rodent stomach. ( Ching, CK; Cho, CH; Chow, JY; Ko, JK; Lam, SK; Zhang, ST, 1997) |
| "Pretreatment with indomethacin only partially counteracted the protective activity of Cu(II)(L-Trp)(L-Phe)." | 1.30 | Prostaglandins and nitric oxide in copper-complex mediated protection against ethanol-induced gastric damage. ( Doria, D; Franco, L, 1997) |
| "In omeprazole-treated rats, the healing of gastric mucosal lesions was accelerated in comparison with those of untreated rats." | 1.30 | Increased hepatocyte growth factor content in rat stomach during omeprazole treatment. ( Chiba, T; Fukui, H; Hassan, MS; Kawamura, M; Kinoshita, Y; Kishi, K; Maekawa, T; Matsushima, Y; Okada, A; Waki, S, 1998) |
| "Pretreatment with indomethacin, which is a prostaglandin synthesis inhibitor and idoacetamide, which is a sulfhydryl blocker did not influence the inhibited ethanol lesion of WBS." | 1.30 | Prevention of ethanol-induced gastric lesions in rats by wu-bei-san. ( Lin, WC, 1998) |
| "When indomethacin was administered to mice deficient in CD18, intercellular adhesion molecule 1 (ICAM-1), or P-selectin, there were significant decreases in lesion scores compared with their C57BL/6 controls." | 1.30 | Indomethacin induced gastropathy in CD18, intercellular adhesion molecule 1, or P-selectin deficient mice. ( Anderson, DC; Fuseler, JW; Granger, DN; Grisham, MB; Morise, Z, 1999) |
| "Clarithromycin protection was not significantly modified by pretreatment with either subcutaneous indomethacin (5 mg/kg), a selective cyclooxygenase inhibitor, or iodoacetamide (100 mg/kg), a specific sulfhydryl blocker." | 1.30 | Gastroprotective effect of intragastric clarithromycin against damage induced by ethanol in rats. ( Gutiérrez-Cabano, CA; Raynald, AC, 1999) |
| "Pretreatment with indomethacin, 10 mg/kg s." | 1.29 | Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins. ( Marhuenda, E; Martín, MJ; Pérez Guerrero, C, 1994) |
| "Flavone (1) was found to protect against ethanol-induced gastric damage in rats; however, it is known that certain compounds in the flavone class, including flavone itself, are inducers of hepatic drug metabolizing enzymes." | 1.29 | Synthesis and biological evaluation of substituted flavones as gastroprotective agents. ( Ares, JJ; Ems, BL; Kakodkar, SV; Kelm, GR; Kershaw, WC; Murray, PD; O'Brien, LM; Outt, PE; Randall, JL; Weisshaar, PS, 1995) |
| "Spermine was given orally at doses of 25, 75 and 150 mg/kg and, intraperitoneally at 10, 25 and 50 mg/kg 1 hour before 25 mg/kg indomethacin administration." | 1.29 | Prevention of indomethacin-induced acute gastric mucosal injury by spermine in the rat. ( Buzás, G; Demel, Z; Hamar, J; Józan, J, 1996) |
| " The result of this study also showed that the concurrent use of the CLO does not affect the bioavailability and anti-inflammatory activity of indomethacin while it inhibits the ulcerogenic effect of indomethacin in a dose dependent manner." | 1.28 | Cod liver oil inhibits indomethacin induced gastropathy without affecting its bioavailability and pharmacological activity. ( al-Meshal, MA; Lutfi, KM; Tariq, M, 1991) |
| "Prednisolone may enhance the degree of mucosal protection afforded by this mechanism." | 1.26 | Influence of prednisolone on ethanol-induced gastric injury in the rat. ( Derelanko, MJ; Long, JF, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (21.67) | 18.7374 |
| 1990's | 44 (36.67) | 18.2507 |
| 2000's | 35 (29.17) | 29.6817 |
| 2010's | 12 (10.00) | 24.3611 |
| 2020's | 3 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Roma, G | 1 |
| Grossi, G | 1 |
| Di Braccio, M | 1 |
| Piras, D | 1 |
| Ballabeni, V | 1 |
| Tognolini, M | 1 |
| Bertoni, S | 1 |
| Barocelli, E | 1 |
| Yu, C | 1 |
| Qiu, J | 1 |
| Xiong, M | 1 |
| Ren, B | 1 |
| Zhong, M | 1 |
| Zhou, S | 1 |
| Li, Y | 3 |
| Zeng, M | 1 |
| Song, H | 1 |
| Li, QJ | 1 |
| Wang, ZG | 1 |
| Xie, Y | 1 |
| Liu, Q | 1 |
| Hu, HL | 1 |
| Gao, YX | 1 |
| Wei, Y | 1 |
| Wang, R | 1 |
| Ren, S | 1 |
| Liu, X | 1 |
| Jing, M | 1 |
| Li, R | 1 |
| Tong, Y | 1 |
| Wen, J | 1 |
| Yang, T | 1 |
| Wang, J | 1 |
| Zhao, Y | 1 |
| Czekaj, R | 1 |
| Majka, J | 2 |
| Magierowska, K | 1 |
| Sliwowski, Z | 1 |
| Magierowski, M | 1 |
| Pajdo, R | 2 |
| Ptak-Belowska, A | 1 |
| Surmiak, M | 1 |
| Kwiecien, S | 2 |
| Brzozowski, T | 3 |
| Lee, YC | 1 |
| Cheng, CW | 1 |
| Lee, HJ | 2 |
| Chu, HC | 1 |
| Werawatganon, D | 1 |
| Rakananurak, N | 1 |
| Sallapant, S | 1 |
| Prueksapanich, P | 1 |
| Somanawat, K | 1 |
| Klaikeaw, N | 1 |
| Rerknimitr, R | 1 |
| Satoh, H | 1 |
| Kondo, R | 1 |
| Shinoda, T | 1 |
| Idaka, S | 1 |
| Ishigami, K | 1 |
| Shiotani, S | 1 |
| Vidal, CS | 1 |
| Oliveira Brito Pereira Bezerra Martins, A | 1 |
| de Alencar Silva, A | 1 |
| de Oliveira, MRC | 1 |
| Ribeiro-Filho, J | 1 |
| de Albuquerque, TR | 1 |
| Coutinho, HDM | 1 |
| da Silva Almeida, JRG | 1 |
| Quintans, LJ | 1 |
| de Menezes, IRA | 1 |
| Pastoris, O | 1 |
| Verri, M | 1 |
| Boschi, F | 1 |
| Kastsiuchenka, O | 1 |
| Balestra, B | 1 |
| Pace, F | 1 |
| Tonini, M | 1 |
| Natale, G | 2 |
| Nagai, N | 1 |
| Fukuhata, T | 1 |
| Ito, Y | 2 |
| Usui, S | 1 |
| Hirano, K | 1 |
| Marchbank, T | 4 |
| Weaver, G | 1 |
| Nilsen-Hamilton, M | 1 |
| Playford, RJ | 4 |
| Gomes, AS | 4 |
| Lemos, HP | 4 |
| Medeiros, JV | 1 |
| Cunha, FQ | 5 |
| Souza, MH | 5 |
| Souza Filho, MV | 1 |
| Loiola, RT | 1 |
| Rocha, EL | 1 |
| Simão, AF | 1 |
| Ribeiro, RA | 3 |
| Jiang, GL | 1 |
| Im, WB | 1 |
| Donde, Y | 1 |
| Wheeler, LA | 1 |
| Kato, S | 4 |
| Ohkawa, F | 1 |
| Amagase, K | 1 |
| Takeuchi, K | 9 |
| Ribeiro-Rama, AC | 1 |
| Figueiredo, IV | 1 |
| Veiga, FJ | 1 |
| Castel-Branco, MM | 1 |
| Cabrita, AM | 1 |
| Caramona, MM | 1 |
| Ojobo, E | 1 |
| Playford, CJ | 1 |
| Valeeva, IKh | 1 |
| Titarenko, AF | 1 |
| Ziganshina, LE | 1 |
| Pal, C | 2 |
| Bindu, S | 2 |
| Dey, S | 2 |
| Alam, A | 2 |
| Goyal, M | 2 |
| Iqbal, MS | 1 |
| Sarkar, S | 1 |
| Kumar, R | 1 |
| Halder, KK | 1 |
| Debnath, MC | 1 |
| Adhikari, S | 1 |
| Bandyopadhyay, U | 2 |
| Nakajima, A | 1 |
| Fukui, T | 1 |
| Takahashi, Y | 1 |
| Kishimoto, M | 1 |
| Yamashina, M | 1 |
| Nakayama, S | 1 |
| Sakaguchi, Y | 1 |
| Yoshida, K | 1 |
| Uchida, K | 1 |
| Nishio, A | 1 |
| Yodoi, J | 1 |
| Okazaki, K | 1 |
| Silva, AA | 1 |
| Bezerra, MM | 1 |
| Chaves, HV | 1 |
| Pereira, KM | 1 |
| Aguiar, JA | 1 |
| Pinto, VP | 1 |
| Abbet, C | 1 |
| Simões-Pires, CA | 1 |
| Franco, ES | 1 |
| Henriques, AT | 1 |
| Hostettmann, K | 1 |
| Maia, MB | 1 |
| Han, YM | 1 |
| Kim, EH | 1 |
| Kim, YJ | 1 |
| Hahm, KB | 1 |
| Tanaka, A | 2 |
| Miyazawa, T | 2 |
| Filaretova, L | 2 |
| Takeeda, M | 1 |
| Ogawa, Y | 1 |
| Nakashima, M | 2 |
| Matsumoto, M | 1 |
| Lee, PR | 1 |
| Kim, SR | 1 |
| Jung, BK | 1 |
| Kim, KR | 1 |
| Chung, JY | 1 |
| Won, HS | 1 |
| Kim, A | 1 |
| Oliveira, RB | 1 |
| Konturek, PC | 1 |
| Nikiforuk, A | 1 |
| Harsch, I | 1 |
| Drozdowicz, D | 2 |
| Hahn, EG | 1 |
| Konturek, SJ | 2 |
| Zanardo, RC | 1 |
| Perretti, M | 1 |
| Wallace, JL | 7 |
| Chiou, SK | 1 |
| Tanigawa, T | 1 |
| Akahoshi, T | 1 |
| Abdelkarim, B | 1 |
| Jones, MK | 1 |
| Tarnawski, AS | 1 |
| Koch, TR | 1 |
| Petro, A | 1 |
| Darrabie, M | 1 |
| Opara, EC | 1 |
| Freire, AO | 1 |
| Sugai, GC | 1 |
| Blanco, MM | 1 |
| Tabosa, A | 1 |
| Yamamura, Y | 1 |
| Mello, LE | 1 |
| Nafeeza, MI | 1 |
| Kang, TT | 1 |
| Belo, A | 1 |
| Fitzgerald, A | 1 |
| Ghosh, S | 1 |
| Santos, CL | 2 |
| Santos, AA | 1 |
| Mózsik, G | 2 |
| Szolcsányi, J | 1 |
| Rácz, I | 1 |
| Bobryshev, P | 1 |
| Bagaeva, T | 1 |
| Fukushima, K | 1 |
| Aoi, Y | 1 |
| Lima, LM | 1 |
| Mota, JM | 1 |
| Soares, PM | 1 |
| Menezes, AA | 1 |
| Brito, GA | 1 |
| de Souza, MH | 1 |
| Naito, Y | 1 |
| Yoshikawa, T | 1 |
| Nishio, H | 1 |
| Terashima, S | 1 |
| Aihara, E | 1 |
| Maity, P | 1 |
| Choubey, V | 1 |
| Mitra, K | 1 |
| Guha, M | 1 |
| Wang, L | 1 |
| Zhou, Y | 1 |
| Peng, J | 1 |
| Zhang, Z | 1 |
| Jiang, DJ | 1 |
| Li, YJ | 1 |
| Tabata, K | 2 |
| Ohtsuki, H | 1 |
| Okabe, S | 4 |
| Visconti, G | 1 |
| Spotti, D | 1 |
| Piperno, A | 1 |
| Marini, U | 1 |
| Derelanko, MJ | 1 |
| Long, JF | 1 |
| Ishihara, Y | 1 |
| Nagaraj, HS | 1 |
| Sandhu, AS | 1 |
| Cook, LN | 1 |
| Buchino, JJ | 1 |
| Groff, DB | 1 |
| Conti, P | 3 |
| Continenza, A | 1 |
| Continenza, MA | 2 |
| Gigante, GE | 1 |
| Cifone, MG | 1 |
| Alesse, E | 1 |
| Bruno, G | 1 |
| Palacios, B | 1 |
| Montero, MJ | 1 |
| Sevilla, MA | 1 |
| Román, LS | 1 |
| Alican, I | 1 |
| Coşkun, T | 1 |
| Corak, A | 1 |
| Yeğen, BC | 1 |
| Oktay, S | 1 |
| Kurtel, H | 1 |
| Kawano, S | 1 |
| Tsuji, S | 1 |
| Masuda, E | 1 |
| Kamada, T | 1 |
| Boichot, E | 1 |
| Sidoti, C | 1 |
| Brecx, A | 1 |
| Paubert-Braquet, M | 1 |
| Pérez Guerrero, C | 1 |
| Martín, MJ | 1 |
| Marhuenda, E | 1 |
| Seibert, K | 1 |
| Zhang, Y | 1 |
| Leahy, K | 1 |
| Hauser, S | 1 |
| Masferrer, J | 1 |
| Perkins, W | 1 |
| Lee, L | 1 |
| Isakson, P | 1 |
| Perkins, WE | 1 |
| Bianchi, RG | 1 |
| Tremont, SJ | 1 |
| Collins, PW | 1 |
| Casler, JJ | 1 |
| Fenton, RL | 1 |
| Wagner, GM | 1 |
| McGrath, MP | 1 |
| Stolzenbach, JC | 1 |
| Kowalski, DL | 1 |
| Karádi, O | 1 |
| Király, A | 1 |
| Matus, Z | 1 |
| Sütö, G | 1 |
| Tóth, G | 1 |
| Vincze, A | 1 |
| Lambrecht, N | 1 |
| Burchert, M | 1 |
| Respondek, M | 1 |
| Müller, KM | 1 |
| Peskar, BM | 2 |
| Meddings, JB | 1 |
| Sutherland, LR | 1 |
| Byles, NI | 1 |
| Ares, JJ | 2 |
| Outt, PE | 1 |
| Randall, JL | 1 |
| Murray, PD | 1 |
| Weisshaar, PS | 2 |
| O'Brien, LM | 2 |
| Ems, BL | 2 |
| Kakodkar, SV | 1 |
| Kelm, GR | 1 |
| Kershaw, WC | 1 |
| Kohagen, KR | 1 |
| Kim, MS | 1 |
| McDonnell, WM | 1 |
| Chey, WD | 1 |
| Owyang, C | 1 |
| Hasler, WL | 1 |
| Gyömber, E | 1 |
| Vattay, P | 1 |
| Szabo, S | 1 |
| Rainsford, KD | 1 |
| Appleyard, CB | 1 |
| McCafferty, DM | 2 |
| Tigley, AW | 1 |
| Swain, MG | 1 |
| Hori, Y | 1 |
| Odaguchi, K | 1 |
| Jyoyama, H | 1 |
| Yasui, K | 1 |
| Mizui, T | 1 |
| Catalano, O | 1 |
| Tanaka, S | 1 |
| Guth, PH | 1 |
| Paulsen, G | 1 |
| Kaunitz, JD | 1 |
| Blank, MA | 1 |
| Abel, PW | 1 |
| Gutierrez-Cabano, CA | 2 |
| Valenti, JL | 1 |
| Buzás, G | 1 |
| Demel, Z | 1 |
| Józan, J | 1 |
| Hamar, J | 1 |
| Bacha, EA | 1 |
| Fernandez, ED | 1 |
| Stroff, T | 1 |
| Enders, G | 1 |
| Krämling, HJ | 1 |
| Ko, JK | 1 |
| Ching, CK | 1 |
| Chow, JY | 1 |
| Zhang, ST | 1 |
| Lam, SK | 1 |
| Cho, CH | 1 |
| Murakami, K | 2 |
| Okajima, K | 2 |
| Uchiba, M | 1 |
| Harada, N | 2 |
| Liu, W | 2 |
| Okabe, H | 2 |
| Takatsuki, K | 1 |
| Franco, L | 1 |
| Doria, D | 1 |
| Matsumaru, K | 1 |
| Kashimura, H | 1 |
| Hassan, M | 1 |
| Nakahara, A | 1 |
| Goto, K | 1 |
| Fukutomi, H | 1 |
| Muto, H | 1 |
| Tanaka, N | 2 |
| Kinoshita, Y | 1 |
| Hassan, MS | 1 |
| Kawamura, M | 1 |
| Matsushima, Y | 1 |
| Okada, A | 1 |
| Maekawa, T | 1 |
| Fukui, H | 1 |
| Waki, S | 1 |
| Kishi, K | 1 |
| Chiba, T | 1 |
| Lin, WC | 1 |
| Morise, Z | 2 |
| Grisham, MB | 2 |
| Rao, PN | 1 |
| Rao, M | 1 |
| Rao, MN | 1 |
| Floyd, DN | 1 |
| Macdonald, CE | 1 |
| Calnan, DP | 1 |
| Adenekan, RO | 1 |
| Johnson, W | 1 |
| Goodlad, RA | 1 |
| Isobe, H | 1 |
| Johno, M | 1 |
| Matsuda, H | 2 |
| Yoshikawa, M | 2 |
| Akar, F | 1 |
| Uydeş-Doğan, BS | 1 |
| Buharalioğlu, CK | 1 |
| Abban, G | 1 |
| Heinemann, A | 1 |
| Holzer, P | 1 |
| Van de Voorde, J | 1 |
| Granger, DN | 1 |
| Fuseler, JW | 1 |
| Anderson, DC | 1 |
| Raynald, AC | 1 |
| Araki, H | 2 |
| Kawauchi, S | 1 |
| Kunikata, T | 1 |
| Mizoguchi, H | 2 |
| Tashima, K | 1 |
| Alekseeva, AV | 1 |
| Murav'ev, IuV | 1 |
| Suzuki, K | 1 |
| Furukawa, O | 1 |
| Bilic, I | 1 |
| Zoricic, I | 1 |
| Anic, T | 1 |
| Separovic, J | 1 |
| Stancic-Rokotov, D | 1 |
| Mikus, D | 1 |
| Buljat, G | 1 |
| Ivankovic, D | 1 |
| Aralica, G | 1 |
| Prkacin, I | 1 |
| Perovic, D | 1 |
| Mise, S | 1 |
| Rotkvic, I | 1 |
| Petek, M | 1 |
| Rucman, R | 1 |
| Seiwerth, S | 1 |
| Sikiric, P | 1 |
| Lazzeri, G | 1 |
| Blandizzi, C | 1 |
| Gherardi, G | 1 |
| Lenzi, P | 1 |
| Pellegrini, A | 1 |
| Del Tacca, M | 1 |
| Bulgen, DY | 1 |
| Hazleman, BL | 1 |
| Menguy, R | 1 |
| Whittle, BJ | 1 |
| Boughton-Smith, NK | 1 |
| Moncada, S | 1 |
| Vane, JR | 1 |
| Morrison, JC | 1 |
| Jennings, JC | 1 |
| Wigley, RA | 1 |
| Fowles, M | 1 |
| Cooke, AR | 1 |
| Guglietta, A | 1 |
| Hervada, T | 1 |
| Nardi, RV | 1 |
| Lesch, CA | 1 |
| Trucco, M | 1 |
| Antonaci, F | 1 |
| Sandrini, G | 1 |
| Rataboli, PV | 1 |
| Bhandare, PN | 1 |
| D'Souza, RS | 1 |
| Dhume, VG | 1 |
| Arfors, KE | 1 |
| McKnight, GW | 1 |
| Polonczyk-Pytko, J | 1 |
| al-Meshal, MA | 1 |
| Lutfi, KM | 1 |
| Tariq, M | 1 |
| Uchida, M | 1 |
| Yano, S | 1 |
| Watanabe, K | 1 |
| Vergin, H | 1 |
| Kori-Lindner, C | 1 |
| Stalnikowicz, R | 1 |
| Goldin, E | 1 |
| Fich, A | 1 |
| Wengrower, D | 1 |
| Eliakim, R | 1 |
| Ligumsky, M | 1 |
| Rachmilewitz, D | 1 |
| Nishiwaki, H | 1 |
| Osano, H | 1 |
| Ebara, S | 1 |
| Romano, M | 1 |
| Razandi, M | 1 |
| Ivey, KJ | 1 |
| Guo, YS | 1 |
| Yang, SJ | 1 |
| Wang, CC | 1 |
| Higuchi, S | 1 |
| Shioiri, Y | 1 |
| Otomo, S | 1 |
| Aihara, H | 1 |
| Müller, P | 1 |
| Dammann, HG | 1 |
| Simon, B | 1 |
| Vasilenko, VKh | 1 |
| Tsodikov, GV | 1 |
| Minushkin, ON | 1 |
| Kapp, F | 1 |
| Baerlocher, C | 1 |
| Fahrländer, H | 1 |
| Bäumer, A | 1 |
| Kelly, M | 1 |
| Arsov, D | 1 |
| PDavcev, P | 1 |
| Vanovski, B | 1 |
| Plasevski, A | 1 |
| Stavrić, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Remote Ischemic Preconditioning on Restenosis Post Lower Limb Revascularization Angioplasty: A Pilot Randomized Control Trial[NCT02406131] | 40 participants (Anticipated) | Interventional | 2018-04-30 | Suspended (stopped due to logistic issues - no available scans for participants at the moment need to postponed starting dates) | |||
| Effects of Esomeprazole Magnesium on Gastric Free Radical Production and Total Antioxidant Capacity in Dyspeptic Patients Receiving Non-steroidal Anti-inflammatory Drugs[NCT00443963] | Phase 4 | 0 participants (Actual) | Interventional | 2006-12-31 | Withdrawn (stopped due to The study was not approved by the Human Studies Subcommittee.) | ||
| GpCRC Pediatric Gastroparesis Registry 2: Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants With Symptoms of Gastroparesis[NCT05981300] | 216 participants (Anticipated) | Observational [Patient Registry] | 2024-02-28 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for indomethacin and Gastric Diseases
| Article | Year |
|---|---|
[Pathogenesis of NSAID-induced gastric mucosal damage--search for primary events and role of COX inhibition].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2002 |
Oxidative stress involvement and gene expression in indomethacin-induced gastropathy.
Topics: Alanine; Animals; Anti-Ulcer Agents; Apoptosis; DNA; Gastric Mucosa; Gene Expression Profiling; Gene | 2006 |
[The most common drugs considered harmful to the stomach, Clinical and endoscopic studies].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents; Aspirin; Dyspepsia; Fema | 1980 |
[Etiological mechanism and drug-induced gastric mucosal lesions].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ethanol; Gastric Mucosa; Humans; Indomethacin; Mic | 1995 |
Molecular mechanisms involved in NSAID-induced gastropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Indomethacin; Leukocytes; Mice; Mod | 1998 |
Analgesics and the stomach.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Indometha | 1976 |
[Effect of some antirheumatic agents on the gastric mucous membrane].
Topics: Adrenocorticotropic Hormone; Aged; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis, Rheuma | 1971 |
5 trials available for indomethacin and Gastric Diseases
| Article | Year |
|---|---|
Gastroprotection induced by capsaicin in healthy human subjects.
Topics: Adult; Capsaicin; Cyclooxygenase Inhibitors; Cytoprotection; Dose-Response Relationship, Drug; Ethan | 2005 |
Alclofenac in ankylosing spondylitis.
Topics: Adult; Blood Sedimentation; Clinical Trials as Topic; Drug Eruptions; Female; Humans; Indomethacin; | 1975 |
Primary dysmenorrhea treated with indomethacin.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Indo | 1979 |
Indomethacin-induced gastroduodenal damage is not affected by cotreatment with ranitidine.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Drug Synergism; Duodenal Diseases; Duodenum; Female; G | 1989 |
[Gastroduodenal tolerability of indomethacin and acetaminophen. A comparative endoscopic study in healthy subjects].
Topics: Acetaminophen; Adult; Double-Blind Method; Drug Tolerance; Duodenal Diseases; Gastric Mucosa; Gastro | 1986 |
108 other studies available for indomethacin and Gastric Diseases
| Article | Year |
|---|---|
1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivity.
Topics: Acute Disease; Amides; Amines; Analgesics; Animals; Anti-Inflammatory Agents; Danazol; Female; Male; | 2008 |
Protective effect of Lizhong Pill on nonsteroidal anti-inflammatory drug-induced gastric mucosal injury in rats: Possible involvement of TNF and IL-17 signaling pathways.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Gastric Mucosa; Indomethacin; Interleuk | 2024 |
Mechanistic evaluation of gastro-protective effects of KangFuXinYe on indomethacin-induced gastric damage in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Gastric Mucosa; Gastrointestinal Agents; Indomethacin; | 2020 |
Zuojin Pill ameliorates inflammation in indomethacin-induced gastric injury via inhibition of MAPK pathway.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Cytokines; Disease Models, Animal; Drugs, Chinese He | 2021 |
Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Capsaicin; CDX2 T | 2018 |
Apple Polyphenol Suppresses Indomethacin-Induced Gastric Damage in Experimental Animals by Lowering Oxidative Stress Status and Modulating the MAPK Signaling Pathway.
Topics: Animals; Gastric Mucosa; Glutathione; Humans; Indomethacin; Male; Malondialdehyde; Malus; MAP Kinase | 2017 |
Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats.
Topics: Aloe; Animals; Anti-Inflammatory Agents; Antioxidants; Chemokine CXCL1; Cytoprotection; Disease Mode | 2014 |
Diets with no or low amounts of dietary fiber can reduce small intestinal ulcers induced by non-steroidal anti-inflammatory drugs in dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Dietary Fiber; Dietary Supplements; Dog | 2016 |
Gastroprotective effect and mechanism of action of Croton rhamnifolioides essential oil in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Croton; Croton Oil; Ethanol; Fe | 2017 |
Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dose-Response Relationship, Dru | 2008 |
Preventive effect of co-administration of water containing magnesium ion on indomethacin induced lesions of gastric mucosa in adjuvant-induced arthritis rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Disease Models, Animal; D | 2009 |
Pancreatic secretory trypsin inhibitor is a major motogenic and protective factor in human breast milk.
Topics: Animals; Apoptosis; Carrier Proteins; Cell Movement; Cell Proliferation; Colostrum; HT29 Cells; Huma | 2009 |
Lipopolysaccharide from Escherichia coli prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence.
Topics: Animals; Cell Adhesion; Disease Models, Animal; Endothelium; Escherichia coli; Gastric Mucosa; Indom | 2009 |
Hind limb ischemic preconditioning induces an anti-inflammatory response by remote organs in rats.
Topics: Acute Disease; Animals; Carrageenan; Cystitis; Edema; Hindlimb; Ifosfamide; Indomethacin; Inflammati | 2009 |
EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Dose | 2009 |
Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Dose-Response Relationshi | 2009 |
Hepatic and renal toxicities of indomethacin acid, salt form and complexed forms with hydroxypropyl-β-cyclodextrin on Wistar rats after oral administration.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta-Cyclodextrins; Dose-Res | 2011 |
Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and rat gastric damage models of injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Cell Proliferation; Cordyceps; Diet | 2011 |
[Comparative analysis of dimephosphon, ionol, and xydiphone effects on indomethacin-induced gastric lesions in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Bone Density Cons | 2010 |
Tryptamine-gallic acid hybrid prevents non-steroidal anti-inflammatory drug-induced gastropathy: correction of mitochondrial dysfunction and inhibition of apoptosis in gastric mucosal cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Electron Tr | 2012 |
Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CXCL1; Cytokines; | 2012 |
Protective effect of Chresta martii extract against indomethacin-induced gastric lesions in mice.
Topics: Animals; Anti-Ulcer Agents; Asteraceae; Flowers; Indomethacin; Male; Mice; Plant Extracts; Plant Lea | 2013 |
A possible involvement of Nrf2-mediated heme oxygenase-1 up-regulation in protective effect of the proton pump inhibitor pantoprazole against indomethacin-induced gastric damage in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Analysis of Variance; Animals; Cells, Cultured; Enzyme Indu | 2012 |
Mechanisms by which endogenous glucocorticoid protects against indomethacin-induced gastric injury in rats.
Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Capillary Permeabili | 2002 |
Facilitation by endogenous prostaglandins of capsaicin-induced gastric protection in rodents through EP2 and IP receptors.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cytoprote | 2003 |
Therapeutic effect of cyclo-oxygenase inhibitors with different isoform selectivity in lipopolysaccharide-induced preterm birth in mice.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Femal | 2003 |
Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice.
Topics: Amidines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylamines; Enzyme Inhibitors; Gastric | 2004 |
Ghrelin-a new gastroprotective factor in gastric mucosa.
Topics: Animals; Blotting, Western; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; | 2004 |
Annexin-1 is an endogenous gastroprotective factor against indomethacin-induced damage.
Topics: Animals; Annexin A1; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesio | 2005 |
Survivin: a novel target for indomethacin-induced gastric injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Culture Techniques; Cyclooxygenase | 2005 |
Effects of esomeprazole magnesium on nonsteroidal anti-inflammatory drug gastropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Esomeprazole; Gastric Emptying; Indo | 2005 |
Effect of moxibustion at acupoints Ren-12 (Zhongwan), St-25 (Tianshu), and St-36 (Zuzanli) in the prevention of gastric lesions induced by indomethacin in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Gastric Mucosa; Indomethacin; Male; Mox | 2005 |
Synergistic effects of tocopherol, tocotrienol, and ubiquinone in indomethacin-induced experimental gastric lesions.
Topics: Animals; Antioxidants; Dinoprostone; Drug Synergism; Drug Therapy, Combination; Gastric Acid; Glutat | 2005 |
Gastroprotective effects of oral nucleotide administration.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Cell Prolifer | 2006 |
Sildenafil prevents indomethacin-induced gastropathy in rats: role of leukocyte adherence and gastric blood flow.
Topics: Animals; Arginine; Cell Adhesion; Chemotaxis, Leukocyte; Dinoprostone; Dose-Response Relationship, D | 2005 |
Gastroprotective action of glucocorticoid hormones in rats with desensitization of capsaicin-sensitive sensory neurons.
Topics: Adrenalectomy; Animals; Blood Glucose; Capsaicin; Dose-Response Relationship, Drug; Drug Tolerance; | 2005 |
Gastro-protective action of lafutidine mediated by capsaicin-sensitive afferent neurons without interaction with TRPV1 and involvement of endogenous prostaglandins.
Topics: 6-Ketoprostaglandin F1 alpha; Acetamides; Animals; Calcium; Capsaicin; Dinoprostone; Dose-Response R | 2006 |
LPS from Escherichia coli protects against indomethacin-induced gastropathy in rats--role of ATP-sensitive potassium channels.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Diazoxide; Es | 2006 |
Amifostine (Wr-2721) prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence.
Topics: Adhesiveness; Amifostine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Enzyme Inh | 2007 |
Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bridged Bicyclo Compounds; Caproates; Cyclooxygenase 1; Cyclo | 2007 |
Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent induction of mucosal cell renewal.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspases; | 2008 |
Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury.
Topics: Amidohydrolases; Animals; Arginine; Campylobacter jejuni; Cell Line; Dose-Response Relationship, Dru | 2008 |
Role of lymphoid nodules in pathogenesis of indomethacin-induced gastric lesions in dogs.
Topics: Administration, Oral; Animals; Dogs; Gastric Mucosa; Indomethacin; Lymphatic System; Male; Pyloric A | 1984 |
Influence of prednisolone on ethanol-induced gastric injury in the rat.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Glucocorticoids; | 1982 |
Effects of cholestyramine and synthetic hydrotalcite on acute gastric or intestinal lesion formation in rats and dogs.
Topics: Aluminum Hydroxide; Animals; Antacids; Carbonates; Cholestyramine Resin; Dogs; Female; Indomethacin; | 1981 |
Gastrointestinal perforation following indomethacin therapy in very low birth weight infants.
Topics: Ductus Arteriosus, Patent; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature, Disease | 1981 |
Effects of 16, 16-dimethyl prostaglandin E2 methyl ester on aspirin-and indomethacin-induced gastrointestinal lesions in dogs.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Dogs; Gastric Mucosa; Indomethacin; Intestinal Dis | 1980 |
Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal.
Topics: Animals; Diflunisal; Drug Therapy, Combination; Granuloma; Indomethacin; Male; Rats; Salicylates; St | 1980 |
[Calcium content of KMnO4 induced granuloma after treatment with 2 combined non-steroidal drugs: indomethacin plus diflunisal].
Topics: Animals; Diflunisal; Drug Interactions; Granuloma; Indomethacin; Male; Potassium Permanganate; Rats; | 1980 |
["Granuloma pouch" reduction after treatment with indomethacin and diflunisal and collateral effects of these drugs on gastric mucosa].
Topics: Animals; Diflunisal; Disease Models, Animal; Gastric Mucosa; Granuloma; Indomethacin; Male; Rats; Sa | 1980 |
JB-9322, a new selective histamine H2-receptor antagonist with potent gastric mucosal protective properties.
Topics: Animals; Aspirin; Ethanol; Gastric Acid; Gastric Mucosa; Guinea Pigs; Histamine H2 Antagonists; In V | 1995 |
Role of neutrophils in indomethacin-induced gastric mucosal lesions in rats.
Topics: Animals; Gastric Mucosa; Glutathione; Indomethacin; Lipid Peroxides; Methotrexate; Neutrophils; Oxid | 1995 |
Protective effects of somatostatin against gastric damage induced by hemorrhagic shock, stress and PAF in the rat.
Topics: Animals; Endotoxins; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Platelet Activating Factor; R | 1993 |
Prevention by rutin of gastric lesions induced by ethanol in rats: role of endogenous prostaglandins.
Topics: Animals; Edema; Ethanol; Gastric Mucosa; Gastrointestinal Hemorrhage; Indomethacin; Male; Prostaglan | 1994 |
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Topics: Abscess; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Gene Expressio | 1994 |
Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem.
Topics: Animals; Antacids; Aspirin; Biological Availability; Butadienes; Depression, Chemical; Diarrhea; Dog | 1994 |
Vagal nerve and the gastric mucosal defense.
Topics: Animals; Capillary Permeability; Dinoprostone; Epoprostenol; Ethanol; Gastric Mucosa; Hydrochloric A | 1993 |
Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat.
Topics: Animals; Antibodies; Arginine; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Gastric M | 1993 |
Sucrose: a novel permeability marker for gastroduodenal disease.
Topics: Animals; Duodenal Diseases; Duodenum; Gastric Mucosa; Humans; Indomethacin; Male; Permeability; Rabb | 1993 |
Synthesis and biological evaluation of substituted flavones as gastroprotective agents.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Flavono | 1995 |
Nicotine effects on prostaglandin-dependent gastric slow wave rhythmicity and antral motility in nonsmokers and smokers.
Topics: Adolescent; Adult; Cyclooxygenase Inhibitors; Eating; Fasting; Female; Gastrointestinal Motility; Hu | 1996 |
Role of early vascular damage in the pathogenesis of gastric haemorrhagic mucosal lesions induced by indomethacin in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Female; Gastr | 1996 |
Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Movement; Gastroi | 1996 |
Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory site in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; B | 1996 |
[Report of 3 cases of greater curvature antral flattening caused by non-steroidal anti-inflammatory agents].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethacin; Male; Pyloric Antrum; | 1996 |
Gastroprotective effect of ranitidine bismuth citrate is associated with increased mucus bismuth concentration in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bismuth; | 1996 |
Flavonoid-induced gastroprotection in rats: role of blood flow and leukocyte adherence.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Disease Models, Animal; Flavonoids; | 1997 |
Thioctic acid protection against ethanol and indomethacin induced gastric mucosal lesions in rats.
Topics: Animals; Ethanol; Female; Gastric Mucosa; Indomethacin; Male; Rats; Rats, Wistar; Stomach Diseases; | 1996 |
Prevention of indomethacin-induced acute gastric mucosal injury by spermine in the rat.
Topics: Acute Disease; Administration, Oral; Animals; Dose-Response Relationship, Drug; Female; Gastric Muco | 1996 |
Gastric antigen challenge releases gastrin and eicosanoids and protects against ethanol.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Antigens; Dinoprost; Eicosanoids; Ethanol; Gastric Mucosa; Ga | 1997 |
The vascular and glandular organoprotective properties of metronidazole in the rodent stomach.
Topics: Animals; Capillary Permeability; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Membrane | 1997 |
Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cephalosporins; Cimetidine; Gastric Mucosa; Glycin | 1997 |
Prostaglandins and nitric oxide in copper-complex mediated protection against ethanol-induced gastric damage.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Dipeptides; Enzyme Inhibitors; Ethanol; Gastric Mu | 1997 |
Phosphoramidon, an inhibitor of endothelin-converting enzyme, prevents indomethacin-induced gastric mucosal damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid Endopeptidases; Endothelin-1; Endoth | 1998 |
Increased hepatocyte growth factor content in rat stomach during omeprazole treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dose-Response Relationship, Dru | 1998 |
Prevention of ethanol-induced gastric lesions in rats by wu-bei-san.
Topics: Animals; Aspirin; Calcium Carbonate; Drugs, Chinese Herbal; Ethanol; Gastric Mucosa; Indomethacin; M | 1998 |
Gastroprotective effect of 1-phenyl-3-(4-hydroxy-3,5-di-tert-butylphenyl)prop-2-en-1-one in rats.
Topics: Animals; Antioxidants; Benzene Derivatives; Copper; Ethanol; Indomethacin; Iron; Lipid Peroxidation; | 1998 |
Bovine colostrum is a health food supplement which prevents NSAID induced gut damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cell Culture Techniques; Cell Division; Ce | 1999 |
Plaunotol prevents indomethacin-induced gastric mucosal injury in rats by inhibiting neutrophil activation.
Topics: Animals; Anti-Ulcer Agents; Calcium; Cell Adhesion Molecules; Diterpenes; Fatty Alcohols; Gastric Mu | 1999 |
Gastroprotections of escins Ia, Ib, IIa, and IIb on ethanol-induced gastric mucosal lesions in rats.
Topics: Animals; Anti-Bacterial Agents; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esci | 1999 |
Roles of capsaicin-sensitive sensory nerves, endogenous nitric oxide, sulfhydryls, and prostaglandins in gastroprotection by momordin Ic, an oleanolic acid oligoglycoside, on ethanol-induced gastric mucosal lesions in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Capsaicin; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Ind | 1999 |
Protective effect of cromakalim and diazoxide, and proulcerogenic effect of glibenclamide on indomethacin-induced gastric injury.
Topics: Animals; Arteries; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, | 1999 |
Indomethacin induced gastropathy in CD18, intercellular adhesion molecule 1, or P-selectin deficient mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD18 Antigens; Cell Adhesion Molecules; Cyclooxyge | 1999 |
Gastroprotective effect of intragastric clarithromycin against damage induced by ethanol in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Bacterial Agents; Body Water; Clarithromycin; Cyclooxyge | 1999 |
Regulatory mechanism of acid secretion in the damaged stomach: role of endogenous nitric oxide.
Topics: Animals; Dinoprostone; Enzyme Inhibitors; Gastric Acid; Histamine Release; Indomethacin; Mast Cells; | 2000 |
[Approaches to prediction of gastropathy development risk due to non-steroidal antiinflammatory drugs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Diclofenac; Gastric Acid; Gastric Mu | 2000 |
Prostaglandin E inhibits indomethacin-induced gastric lesions through EP-1 receptors.
Topics: Animals; Dinoprostone; Gastric Mucosa; Gastrointestinal Motility; Indomethacin; Male; Mice; Mice, Kn | 2001 |
Haloperidol-stomach lesions attenuation by pentadecapeptide BPC 157, omeprazole, bromocriptine, but not atropine, lansoprazole, pantoprazole, ranitidine, cimetidine and misoprostol in mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Atropine; Benzimidazoles; Bromo | 2001 |
Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Mis | 2001 |
Gastric mucosal injury from common drugs.
Topics: Adrenal Cortex Hormones; Aspirin; Drug-Related Side Effects and Adverse Reactions; Gastric Mucosa; G | 1978 |
Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1alpha on the rat gastric mucosa in vivo and in vitro.
Topics: Animals; Epoprostenol; Gastric Juice; Gastric Mucosa; Indomethacin; Infusions, Parenteral; Pentagast | 1978 |
Drugs and gastric damage.
Topics: Adrenal Cortex Hormones; Aspirin; Buffers; Caffeine; Drug Compounding; Drug-Related Side Effects and | 1976 |
Effect of platelet-derived growth factor-BB on indomethacin-induced gastric lesions in rats.
Topics: Animals; Gastric Acid; Indomethacin; Male; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawle | 1992 |
Hemicrania continua: a case responsive to piroxicam-beta-cyclodextrin.
Topics: beta-Cyclodextrins; Chronic Disease; Cyclodextrins; Drug Combinations; Female; Humans; Indomethacin; | 1992 |
Protective effect of propranolol on ethanol-induced gastric lesions in rats: probable mechanism of action.
Topics: Animals; Drug Interactions; Ethanol; Gastric Fundus; Gastrointestinal Hemorrhage; Indomethacin; Lido | 1992 |
A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Surface; CD18 Antigens; Cell Adhesion; Endo | 1991 |
Role of polyamines in gastroprotection induced by epidermal growth factor.
Topics: Animals; Aspirin; Dinoprostone; Eflornithine; Epidermal Growth Factor; Ethanol; Gastric Acid; Gastri | 1991 |
Cod liver oil inhibits indomethacin induced gastropathy without affecting its bioavailability and pharmacological activity.
Topics: Administration, Oral; Animals; Biological Availability; Cod Liver Oil; Female; Gastric Mucosa; Indom | 1991 |
The role of capsaicin-sensitive afferent nerves in protective effect of capsaicin against absolute ethanol-induced gastric lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Disease Models, Animal; Ethanol; Gastri | 1991 |
Putative mechanisms of cytoprotective effect of certain antacids and sucralfate.
Topics: Aluminum Hydroxide; Animals; Antacids; Dinoprostone; Dose-Response Relationship, Drug; Ethanol; Gast | 1990 |
Repair of mucosal damage induced by ethanol in the rat stomach. Effects of concentration, exposure period and prostaglandins.
Topics: Administration, Cutaneous; Animals; Dinoprostone; Ethanol; Gastric Mucosa; Hydrogen-Ion Concentratio | 1988 |
Acetaminophen directly protects human gastric epithelial cell monolayers against damage induced by sodium taurocholate.
Topics: Acetaminophen; Cells, Cultured; Dinoprostone; Epithelial Cells; Epithelium; Gastric Mucosa; Histocyt | 1988 |
[Effect of peanut oil and oleic acid on indomethacin-induced gastric mucosal damage in rats].
Topics: Animals; Female; Gastric Mucosa; Indomethacin; Male; Oils; Oleic Acids; Peanut Oil; Plant Oils; Rats | 1985 |
[The modes of anti-inflammatory and analgesic actions of 2-[4-(3-methyl-2-butenyl) phenyl] propionic acid (TA-60) and 2-[4-(2,2-dichlorovinyl) phenyl] propionic acid (TA-668) and effect of TA-60 on the gastrointestinal tract].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Diarrhea | 1985 |
[Drugs and gastric hemorrhage. Results of 1 year's prospective study].
Topics: Alcoholic Beverages; Anticoagulants; Blood Transfusion; Cortisone; Drug Therapy, Combination; Gastro | 1974 |
[Experiences with indomethacin in therapy of rheumatoid disease].
Topics: Adult; Age Factors; Arthritis; Arthritis, Reactive; Arthritis, Rheumatoid; Gout; Headache; Humans; I | 1971 |
Treatment of 193 rheumatic patients with indomethacin, a new antirheumatic drug.
Topics: Arthritis, Rheumatoid; Fibromyalgia; Gout; Indomethacin; Stomach Diseases | 1966 |
[Changes in the gastric mucosa by peroral antirheumatic drugs].
Topics: Anti-Inflammatory Agents; Antipyrine; Aspirin; Gastric Acidity Determination; Gastric Mucosa; Humans | 1969 |