indomethacin has been researched along with Fractures, Bone in 42 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Fractures, Bone: Breaks in bones.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The extent of heterotopic ossification was evaluated on plain radiographs three months after operation." | 2.72 | Indometacin as prophylaxis for heterotopic ossification after the operative treatment of fractures of the acetabulum. ( Bosse, MJ; Goulet, JA; Karunakar, MA; Kellam, JF; Sen, A; Sims, SH, 2006) |
| "Grade-I, II, and III heterotopic ossification did not decrease the range of motion of the hip except in flexion." | 2.70 | Indomethacin compared with localized irradiation for the prevention of heterotopic ossification following surgical treatment of acetabular fractures. ( Anglen, JO; Burd, TA; Lowry, KJ, 2001) |
| "Indomethacin, 25 mg, was given three times daily for six weeks." | 2.69 | Indomethacin versus radiation therapy for prophylaxis against heterotopic ossification in acetabular fractures: a randomised, prospective study. ( Anglen, JO; Goss, K; Moore, KD, 1998) |
| "Indomethacin was therefore not effective in preventing ectopic bone formation after surgery for acetabular fractures." | 2.68 | Does indomethacin reduce heterotopic bone formation after operations for acetabular fractures? A prospective randomised study. ( Matta, JM; Siebenrock, KA, 1997) |
| "Indomethacin was given as daily doses of 25 mg started within 24 hours of operation and continued for four weeks." | 2.67 | Low-dose irradiation and indomethacin prevent heterotopic ossification after acetabular fracture surgery. ( Letournel, E; Moed, BR, 1994) |
| "Heterotopic ossification is a well-known complication after fixation of an acetabular fracture." | 2.45 | Is radiation superior to indomethacin to prevent heterotopic ossification in acetabular fractures?: a systematic review. ( Blokhuis, TJ; Frölke, JP, 2009) |
| "Only one patient developed a heterotopic ossification." | 2.43 | [Value of a combined ossification prophylaxis with indomethacin and radiotherapy for acetabular fractures]. ( Arbter, D; Piatek, S; Westphal, T; Winckler, S, 2006) |
| "The incidence of acute infection and heterotopic ossification was 0% and 2%, respectively." | 2.39 | Management of complex acetabular fractures through single nonextensile exposures. ( Helfet, DL; Schmeling, GJ, 1994) |
| "Indomethacin was prescribed to all patients for heterotopic ossification prophylaxis for a total of 6 weeks postoperatively." | 1.40 | A surgical approach algorithm for transverse posterior wall fractures aids in reduction quality. ( Bogdan, Y; Dwivedi, S; Tornetta, P, 2014) |
| "We previously found no reduction in heterotopic ossification (HO) rates after acetabular surgery with indomethacin compared with a placebo." | 1.39 | Heterotopic ossification rates after acetabular fracture surgery are unchanged without indomethacin prophylaxis. ( Griffin, SM; Haines, N; Karunakar, MA; Seymour, R; Sims, SH, 2013) |
| " Facilitation of osteoblast apoptosis occurred regardless of IND dosage under hypoxic conditions." | 1.38 | Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury. ( Chang, CH; Chen, YC; Fan, SC; Huang, CH; Liu, C; Tsai, AL; Wu, CC, 2012) |
| "Six developed heterotopic ossification." | 1.29 | Results of 75 consecutive patients with an acetabular fracture. ( de Lange, S; de Ridder, VA; Hogervorst, M; Kingma, L, 1994) |
| "The severity of heterotopic ossification was evaluated for each of these two patient groups using the Brooker classification and was correlated with hip joint mobility." | 1.29 | Prophylactic indomethacin for the prevention of heterotopic ossification after acetabular fracture surgery in high-risk patients. ( Karges, DE; Moed, BR, 1994) |
| " These animals were then assigned randomly to dose groups (1, 2 or 4 mg/kg/day of indomethacin and 100, 200, or 300 mg/kg/day of aspirin) and were dosed for 21 days." | 1.26 | Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. ( Allen, HL; Bear, WT; Wase, A, 1980) |
| "Indomethacin plasma levels were about 1 microgram/ml in the indomethacin-treated animals." | 1.26 | Inhibition of fracture healing by indomethacin in rats. ( Bessesen, A; Dregelid, E; Mørland, J; Sudmann, E, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (14.29) | 18.7374 |
| 1990's | 13 (30.95) | 18.2507 |
| 2000's | 10 (23.81) | 29.6817 |
| 2010's | 11 (26.19) | 24.3611 |
| 2020's | 2 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, JM | 1 |
| Liu, KC | 1 |
| Yeh, WL | 1 |
| Chen, JC | 1 |
| Liu, SJ | 1 |
| Cichos, KH | 1 |
| Spitler, CA | 1 |
| Quade, JH | 1 |
| Almaguer, A | 1 |
| McGwin, G | 1 |
| Ghanem, ES | 1 |
| Griffin, SM | 1 |
| Sims, SH | 2 |
| Karunakar, MA | 2 |
| Seymour, R | 1 |
| Haines, N | 1 |
| Sagi, HC | 1 |
| Jordan, CJ | 1 |
| Barei, DP | 1 |
| Serrano-Riera, R | 1 |
| Steverson, B | 1 |
| Bogdan, Y | 1 |
| Dwivedi, S | 1 |
| Tornetta, P | 1 |
| Firoozabadi, R | 1 |
| O'Mara, TJ | 1 |
| Swenson, A | 1 |
| Agel, J | 1 |
| Beck, JD | 1 |
| Routt, M | 1 |
| Burnet, NG | 1 |
| Nasr, P | 1 |
| Yip, G | 1 |
| Scaife, JE | 1 |
| House, T | 1 |
| Thomas, SJ | 1 |
| Harris, F | 1 |
| Owen, PJ | 1 |
| Hull, P | 1 |
| Elhassan, Y | 1 |
| Abdelhaq, A | 1 |
| Piggott, RP | 1 |
| Osman, M | 1 |
| McElwain, JP | 1 |
| Leonard, M | 1 |
| Sandilands, SM | 1 |
| Raudenbush, BL | 1 |
| Carreira, DS | 1 |
| Cross, BJ | 1 |
| Blokhuis, TJ | 1 |
| Frölke, JP | 1 |
| Dimmen, S | 1 |
| Liu, C | 1 |
| Tsai, AL | 1 |
| Chen, YC | 1 |
| Fan, SC | 1 |
| Huang, CH | 1 |
| Wu, CC | 1 |
| Chang, CH | 1 |
| Mourad, WF | 2 |
| Packianathan, S | 2 |
| Shourbaji, RA | 2 |
| Zhang, Z | 2 |
| Graves, M | 2 |
| Khan, MA | 2 |
| Baird, MC | 2 |
| Russell, G | 2 |
| Vijayakumar, S | 2 |
| Amstutz, HC | 1 |
| Dorey, FJ | 2 |
| Beaulé, PE | 1 |
| Burd, TA | 2 |
| Hughes, MS | 1 |
| Anglen, JO | 3 |
| Piatek, S | 1 |
| Westphal, T | 1 |
| Arbter, D | 1 |
| Winckler, S | 1 |
| Sen, A | 1 |
| Bosse, MJ | 2 |
| Goulet, JA | 1 |
| Kellam, JF | 1 |
| Karachalios, T | 1 |
| Boursinos, L | 1 |
| Poultsides, L | 1 |
| Khaldi, L | 1 |
| Malizos, KN | 1 |
| Elves, MW | 1 |
| Bayley, I | 1 |
| Roylance, PJ | 1 |
| Allen, HL | 1 |
| Wase, A | 1 |
| Bear, WT | 1 |
| Moed, BR | 3 |
| Letournel, E | 2 |
| Johnson, EE | 2 |
| Matta, JM | 2 |
| Mast, JW | 2 |
| Ruesch, PD | 1 |
| Holdener, H | 1 |
| Ciaramitaro, M | 1 |
| de Ridder, VA | 1 |
| de Lange, S | 1 |
| Kingma, L | 1 |
| Hogervorst, M | 1 |
| Helfet, DL | 1 |
| Schmeling, GJ | 1 |
| Kay, RM | 1 |
| Karges, DE | 1 |
| Maxey, JW | 1 |
| Siebenrock, KA | 1 |
| Moore, KD | 1 |
| Goss, K | 1 |
| Lowry, KJ | 1 |
| Hui, JY | 1 |
| Woo, PC | 1 |
| Lo, SS | 1 |
| Chan, JC | 1 |
| Michalak, RE | 1 |
| Sudmann, E | 2 |
| Dregelid, E | 1 |
| Bessesen, A | 1 |
| Mørland, J | 1 |
| Ragnarsson, B | 1 |
| Danckwardt-Lillieström, G | 1 |
| Mjöberg, B | 1 |
| McLaren, AC | 1 |
| Webb, LX | 1 |
| Mayo, KA | 1 |
| Lange, RH | 1 |
| Miller, ME | 1 |
| Swiontkowski, MF | 1 |
| Sato, S | 1 |
| Kim, T | 1 |
| Arai, T | 1 |
| Maruyama, S | 1 |
| Tajima, M | 1 |
| Utsumi, N | 1 |
| Dittmar, FK | 1 |
| el-Salamouny, AR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| External Beam Radiotherapy as Prophylaxis for Heterotopic Ossification After Surgical Fixation of Acetabular Fractures: a Prospective, Randomized Feasibility Study[NCT04867278] | 60 participants (Anticipated) | Interventional | 2021-05-09 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for indomethacin and Fractures, Bone
| Article | Year |
|---|---|
Is radiation superior to indomethacin to prevent heterotopic ossification in acetabular fractures?: a systematic review.
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Fractures, Bone; Humans; Indomethacin; Ossifica | 2009 |
[Value of a combined ossification prophylaxis with indomethacin and radiotherapy for acetabular fractures].
Topics: Acetabulum; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Ther | 2006 |
Management of complex acetabular fractures through single nonextensile exposures.
Topics: Acetabulum; Adolescent; Adult; Aged; Child; Female; Fracture Fixation, Internal; Fractures, Bone; Hu | 1994 |
7 trials available for indomethacin and Fractures, Bone
| Article | Year |
|---|---|
Indomethacin prophylaxis for heterotopic ossification after acetabular fracture surgery increases the risk for nonunion of the posterior wall.
Topics: Acetabulum; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Fracture Heali | 2014 |
Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion.
Topics: Acetabulum; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arm Injuries; Fracture Fixation; F | 2003 |
Indometacin as prophylaxis for heterotopic ossification after the operative treatment of fractures of the acetabulum.
Topics: Acetabulum; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; F | 2006 |
Low-dose irradiation and indomethacin prevent heterotopic ossification after acetabular fracture surgery.
Topics: Acetabulum; Adolescent; Adult; Aged; Combined Modality Therapy; Female; Follow-Up Studies; Fractures | 1994 |
Does indomethacin reduce heterotopic bone formation after operations for acetabular fractures? A prospective randomised study.
Topics: Acetabulum; Adolescent; Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; | 1997 |
Indomethacin versus radiation therapy for prophylaxis against heterotopic ossification in acetabular fractures: a randomised, prospective study.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cau | 1998 |
Indomethacin compared with localized irradiation for the prevention of heterotopic ossification following surgical treatment of acetabular fractures.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agen | 2001 |
32 other studies available for indomethacin and Fractures, Bone
| Article | Year |
|---|---|
Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies.
Topics: 3T3 Cells; Analgesics; Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Compoundin | 2020 |
Do Indomethacin or Radiation for Heterotopic Ossification Prophylaxis Increase the Rates of Infection or Wound Complications After Acetabular Fracture Surgery?
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Fractures, Bone; Humans; Indomethacin; Ossifica | 2020 |
Heterotopic ossification rates after acetabular fracture surgery are unchanged without indomethacin prophylaxis.
Topics: Acetabulum; Adult; Female; Follow-Up Studies; Fracture Fixation, Internal; Fractures, Bone; Humans; | 2013 |
A surgical approach algorithm for transverse posterior wall fractures aids in reduction quality.
Topics: Acetabulum; Adolescent; Adult; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Evidence-Based M | 2014 |
Risk factors for the development of heterotopic ossification after acetabular fracture fixation.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Causality; Child; Comorbidity; Female; Follo | 2014 |
Prophylactic radiotherapy against heterotopic ossification following internal fixation of acetabular fractures: a comparative estimate of risk.
Topics: Acetabuloplasty; Acetabulum; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal | 2014 |
Heterotopic Ossification following acetabular fixation: Incidence and risk factors: 10-year experience of a tertiary centre.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chi | 2016 |
Extra-articular hip impingement due to heterotopic ossification formation at the anterior inferior iliac spine following previous pelvic external fixation.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; Femoracetabular Impingement; Fractures, | 2016 |
Effects of Cox inhibitors on bone and tendon healing.
Topics: Animals; Biomechanical Phenomena; Bone Density; Cyclooxygenase Inhibitors; Female; Fracture Healing; | 2011 |
Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury.
Topics: Alkaline Phosphatase; Animals; Apoptosis; Aspirin; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Ce | 2012 |
A prolonged time interval between trauma and prophylactic radiation therapy significantly increases the risk of heterotopic ossification.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chi | 2012 |
The impact of body mass index on heterotopic ossification.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Bod | 2012 |
Prevention of heterotopic bone formation and type-II errors.
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Fractures, Bone; Humans; Indomethacin; Ossifica | 2002 |
Prevention of heterotopic bone formation and type-II errors.
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Fractures, Bone; Humans; Indomethacin; Ossifica | 2002 |
The effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures. An experimental study in rabbits.
Topics: Analysis of Variance; Animals; Bony Callus; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Fra | 2007 |
The effect of indomethacin upon experimental fractures in the rat.
Topics: Age Factors; Animals; Bone and Bones; Bone Transplantation; Fractures, Bone; Indomethacin; Male; Ost | 1982 |
Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat.
Topics: Animals; Aspirin; Cartilage; Dose-Response Relationship, Drug; Fractures, Bone; Indomethacin; Male; | 1980 |
Delayed reconstruction of acetabular fractures 21-120 days following injury.
Topics: Acetabulum; Adolescent; Adult; Aged; Diphosphonates; Female; Fracture Fixation, Internal; Fractures, | 1994 |
A prospective study of surgically treated acetabular fractures.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Fracture Fixation, Internal; | 1994 |
Results of 75 consecutive patients with an acetabular fracture.
Topics: Acetabulum; Adolescent; Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Fracture Fixation | 1994 |
Heterotopic ossification prophylaxis following operative treatment of acetabular fracture.
Topics: Acetabulum; Adolescent; Adult; Aged; Child; Female; Fracture Fixation, Internal; Fractures, Bone; Hu | 1994 |
Prophylactic indomethacin for the prevention of heterotopic ossification after acetabular fracture surgery in high-risk patients.
Topics: Acetabulum; Adolescent; Adult; Follow-Up Studies; Fracture Fixation, Internal; Fractures, Bone; Huma | 1994 |
The effect of indomethacin on heterotopic ossification following acetabular fracture surgery.
Topics: Acetabulum; Adolescent; Adult; Child; Female; Fracture Fixation, Internal; Fractures, Bone; Humans; | 1993 |
Over-the-counter medication and its effects.
Topics: Abscess; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cushing Syndrome; | 2002 |
Prevention of heterotopic bone formation and type-II errors.
Topics: Acetabulum; Anti-Inflammatory Agents, Non-Steroidal; Fractures, Bone; Humans; Indomethacin; Ossifica | 2002 |
Inhibition of fracture healing by indomethacin in rats.
Topics: Animals; Body Weight; Fractures, Bone; Fractures, Closed; Indomethacin; Male; Placebos; Radiography; | 1979 |
[Letter: Indomethacin and fracture healing. Risk of delayed healing and development of pseudarthrosis].
Topics: Animals; Cell Differentiation; Fractures, Bone; Humans; Indomethacin; Inflammation; Male; Middle Age | 1976 |
The triradiate incision for acetabular fractures. A prospective study of 23 cases.
Topics: Acetabulum; Adolescent; Adult; Aged; Combined Modality Therapy; Female; Fractures, Bone; Gait; Hospi | 1992 |
Prophylaxis with indomethacin for heterotopic bone. After open reduction of fractures of the acetabulum.
Topics: Acetabulum; Adult; Buttocks; Female; Fracture Fixation, Internal; Fractures, Bone; Humans; Indometha | 1990 |
Results in patients with craniocerebral trauma and an operatively managed acetabular fracture.
Topics: Acetabulum; Adolescent; Adult; Aged; Brain Injuries; Etidronic Acid; Female; Fracture Fixation, Inte | 1990 |
Comparison between the effects of dexamethasone and indomethacin on bone wound healing.
Topics: Animals; Calcium; Dexamethasone; Fractures, Bone; Indomethacin; Male; Radiography; Rats; Rats, Inbre | 1986 |
[Experiences with an indoleacetic acid derivate (Indomethacin) in the therapy of posttraumatic and postoperative edema].
Topics: Abscess; Cellulitis; Edema; Fractures, Bone; Humans; Indomethacin; Inflammation; Intestinal Neoplasm | 1968 |