indomethacin has been researched along with Fibrosarcoma in 40 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
Excerpt | Relevance | Reference |
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"We have previously reported that both regressor (QR) and progressor (metastatic, QP) clones were obtained after the in vitro exposure of a mouse fibrosarcoma BMT-11 cl-9 to quercetin." | 7.68 | Regression mechanisms of mouse fibrosarcoma cells after in vitro exposure to quercetin: diminution of tumorigenicity with a corresponding decrease in the production of prostaglandin E2. ( Chiba, I; Hasegawa, J; Hosokawa, M; Ishikawa, M; Kobayashi, H; Nakamura, Y; Okada, F, 1990) |
"Indomethacin, a non-steroidal anti-inflammatory drug which is also a calcium antagonist and an inhibitor of prostaglandin synthesis was observed to have a chemotherapeutic effect in a mouse fibrosarcoma." | 7.67 | Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma. ( Shenoy, MA; Singh, BB, 1989) |
"Using HSDM1 C1 cell line derived from the mouse fibrosarcoma which synthesizes and secretes prostaglandin (PG) E2, specific binding sites for epidermal growth factor (EGF), a potent growth stimulator of many tissues, and its effect on PGE2 production by cultured tumor cells were studied." | 7.67 | Stimulatory effect of epidermal growth factor on prostaglandin E2 production in mouse fibrosarcoma cell line (HSDM1 C1). ( Fujita, T; Hirata, Y; Matsukura, S; Nakashima, H; Uchihashi, M, 1985) |
"The relationship between bradykinin (BK)-induced prostaglandin E2 (PGE2) and cyclic AMP syntheses in mouse fibrosarcoma cells (HSDM1C1) was investigated." | 7.67 | Bradykinin-induced cyclic AMP accumulation in mouse fibrosarcoma independent of prostaglandin E2 formation. ( Fujimoto, M; Okabayashi, T, 1986) |
"Indomethacin was used as a non-steroidal anti-inflammatory agent to neutralize the inflammatory action of Carrageenan." | 5.31 | [Effect of carrageenan and indomethacin on the growth of a murine fibrosarcoma]. ( Davolio, S; Mercau, G; Torres Nieto de Mercau, GN; Valdez, JC; Vitalone, HH, 2000) |
" We report here that inhibitors of both the cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism convert mouse melanoma and human fibrosarcoma cells to a non invasive state by reducing the production of MMP-2, an enzyme required for the degradation of basement membranes." | 3.69 | Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells. ( Martin, GR; Reich, R, 1996) |
"We have previously reported that both regressor (QR) and progressor (metastatic, QP) clones were obtained after the in vitro exposure of a mouse fibrosarcoma BMT-11 cl-9 to quercetin." | 3.68 | Regression mechanisms of mouse fibrosarcoma cells after in vitro exposure to quercetin: diminution of tumorigenicity with a corresponding decrease in the production of prostaglandin E2. ( Chiba, I; Hasegawa, J; Hosokawa, M; Ishikawa, M; Kobayashi, H; Nakamura, Y; Okada, F, 1990) |
"In this report we describe results showing that both arachidonic acid (20:4) release and prostaglandin (PG) synthesis in herpes simplex virus type 2 (HSV-2)-transformed tumor-derived rat fibrosarcoma (RFS) cells are inhibited by indomethacin (cyclooxygenase inhibitor)." | 3.67 | Studies of phospholipase and cyclooxygenase activities in herpes simplex virus type 2-transformed rat cells. ( Heitman, CR; Kucera, LS; Waite, M, 1989) |
"Indomethacin, a non-steroidal anti-inflammatory drug which is also a calcium antagonist and an inhibitor of prostaglandin synthesis was observed to have a chemotherapeutic effect in a mouse fibrosarcoma." | 3.67 | Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma. ( Shenoy, MA; Singh, BB, 1989) |
"Using HSDM1 C1 cell line derived from the mouse fibrosarcoma which synthesizes and secretes prostaglandin (PG) E2, specific binding sites for epidermal growth factor (EGF), a potent growth stimulator of many tissues, and its effect on PGE2 production by cultured tumor cells were studied." | 3.67 | Stimulatory effect of epidermal growth factor on prostaglandin E2 production in mouse fibrosarcoma cell line (HSDM1 C1). ( Fujita, T; Hirata, Y; Matsukura, S; Nakashima, H; Uchihashi, M, 1985) |
"The relationship between bradykinin (BK)-induced prostaglandin E2 (PGE2) and cyclic AMP syntheses in mouse fibrosarcoma cells (HSDM1C1) was investigated." | 3.67 | Bradykinin-induced cyclic AMP accumulation in mouse fibrosarcoma independent of prostaglandin E2 formation. ( Fujimoto, M; Okabayashi, T, 1986) |
"Indomethacin, an inhibitor of prostaglandin (PG) synthesis, was investigated for its ability to increase radioresponse of two fibrosarcomas, FSA and NFSA, in C3Hf/Kam mice." | 3.67 | Increase in radioresponse of murine tumors by treatment with indomethacin. ( Barkley, T; Furuta, Y; Hall, E; Hunter, N; Milas, L, 1988) |
"The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth." | 3.66 | Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat. ( Peterson, HI, 1983) |
"Indomethacin was continuously administered in the drinking water of inbred C3H mice given grafts of syngeneic 3-methylcholanthrene-induced fibrosarcomas." | 3.66 | Tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice. ( Lynch, NR; Salomon, JC, 1979) |
"The growth of a 3-methylcholanthrene-induced fibrosarcoma of C3H mice was inhibited by aspirin and indomethacin." | 3.66 | Mechanism of inhibition of tumour growth by aspirin and indomethacin. ( Astoin, M; Castes, M; Lynch, NR; Salomon, JC, 1978) |
" In the present study, [3H]arachidonate-labeled phospholipids of HSDM1C1 cells, a cell line derived from a mouse fibrosarcoma, were examined to determine the donor of the arachidonic acid released upon bradykinin stimulation of the synthesis of PGE2." | 3.66 | Bradykinin-stimulated release of [3H]arachidonic acid from phospholipids of HSDM1C1 cells: comparison of diacyl phospholipids and plasmalogens as sources of prostaglandin precursors. ( Blank, ML; Schremmer, JM; Wykle, RL, 1979) |
"Indomethacin was used as a non-steroidal anti-inflammatory agent to neutralize the inflammatory action of Carrageenan." | 1.31 | [Effect of carrageenan and indomethacin on the growth of a murine fibrosarcoma]. ( Davolio, S; Mercau, G; Torres Nieto de Mercau, GN; Valdez, JC; Vitalone, HH, 2000) |
"Indomethacin treatment did not effect the suppression caused by Mac-1+ M phi, suggesting that proataglandin E2 was not involved." | 1.28 | Modulation of alloreactivity by Mac-1+, -2+, and -3+ macrophages from normal and tumor-bearing hosts: flow cytofluorometrically separated macrophages. ( Askew, D; Burger, CJ; Elgert, KD, 1990) |
"When indomethacin or ibuprofen-treated cells were compared to control cells in regards to motility, they were more active." | 1.27 | Modulation of tumor cell motility by prostaglandins and inhibitors of prostaglandin synthesis. ( Fligiel, SE; He, XM; Varani, J, 1986) |
"Third, indomethacin, treatment of fibrosarcoma cultures reduced the amount of supernatant inhibitory substance present." | 1.26 | Inhibition of lymphoma cell proliferation by supernatant from fibrosarcoma cultures: preliminary evidence that the inhibitory material is prostaglandin E. ( Sonis, ST; Stelos, P; Stylos, WA; Wilson, RE, 1977) |
"The specific bone resorption-stimulating activity of the HSDM(1) factor extracted from the tumor is high and approximately equal to that of PGE(2) as measured in a bone tissue culture system in vitro." | 1.25 | Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer. ( Goldhaber, P; Levine, L; Tashjian, AH; Voelkel, EF, 1972) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 24 (60.00) | 18.7374 |
1990's | 14 (35.00) | 18.2507 |
2000's | 2 (5.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Bustuoabad, OD | 1 |
di Gianni, PD | 1 |
Franco, M | 1 |
Kordon, EC | 1 |
Vanzulli, SI | 1 |
Meiss, RP | 1 |
Grion, LC | 1 |
Díaz, GS | 1 |
Nosetto, SH | 1 |
Hockl, P | 1 |
Lombardi, MG | 1 |
Pasqualini, CD | 1 |
Ruggiero, RA | 1 |
Peterson, HI | 1 |
Shibata, Y | 1 |
Shibuya, E | 1 |
Ishida, N | 1 |
Hogan, KT | 1 |
Hollingsworth, MA | 1 |
Seymour, RE | 1 |
Quinn, MK | 1 |
Evans, DL | 1 |
Garrigues, HJ | 1 |
Romero, P | 1 |
Hellström, I | 1 |
Hellström, KE | 1 |
Plescia, OJ | 1 |
Pontieri, GM | 1 |
Brown, J | 1 |
Racis, S | 1 |
Ippoliti, F | 1 |
Bellelli, L | 1 |
Sezzi, ML | 1 |
Lipari, M | 1 |
Mahboubi, K | 1 |
Ferreri, NR | 1 |
Brekke, OL | 2 |
Espevik, T | 2 |
Bjerve, KS | 2 |
Reich, R | 1 |
Martin, GR | 1 |
Vitalone, HH | 1 |
Torres Nieto de Mercau, GN | 1 |
Valdez, JC | 2 |
Davolio, S | 1 |
Mercau, G | 1 |
Lynch, NR | 2 |
Salomon, JC | 2 |
Castes, M | 1 |
Astoin, M | 1 |
Schremmer, JM | 1 |
Blank, ML | 1 |
Wykle, RL | 1 |
Sonis, ST | 1 |
Stelos, P | 1 |
Stylos, WA | 1 |
Wilson, RE | 1 |
Tashjian, AH | 5 |
Voelkel, EF | 5 |
McDonough, J | 1 |
Levine, L | 5 |
Walker, TM | 2 |
Yurochko, AD | 2 |
Burger, CJ | 3 |
Elgert, KD | 4 |
Bardal, T | 1 |
Perdigón, G | 1 |
Belizario, JE | 1 |
Dinarello, CA | 1 |
Young, MR | 1 |
Okada, F | 2 |
Tada, M | 1 |
Hosokawa, M | 2 |
Kobayashi, H | 2 |
Quere, P | 1 |
Tsiagbe, VK | 1 |
Thorbecke, GJ | 1 |
Askew, D | 1 |
MacIntyre, JP | 1 |
Hoskin, DW | 1 |
Pope, BL | 2 |
Milas, L | 3 |
Furuta, Y | 3 |
Hunter, N | 2 |
Nishiguchi, I | 1 |
Runkel, S | 1 |
Hasegawa, J | 1 |
Ishikawa, M | 1 |
Chiba, I | 1 |
Nakamura, Y | 1 |
Heitman, CR | 1 |
Waite, M | 1 |
Kucera, LS | 1 |
Shenoy, MA | 1 |
Singh, BB | 1 |
Malick, AP | 1 |
Garner, RE | 1 |
Adkinson, NF | 1 |
Hirata, Y | 1 |
Uchihashi, M | 1 |
Nakashima, H | 1 |
Fujita, T | 1 |
Matsukura, S | 1 |
Fujimoto, M | 1 |
Okabayashi, T | 1 |
Hall, ER | 1 |
Sanduja, S | 1 |
Barkley, T | 2 |
Mizushima, Y | 1 |
Morikage, T | 1 |
Hirata, H | 1 |
Sato, M | 1 |
Sakamoto, K | 1 |
Yano, S | 1 |
Hall, E | 1 |
He, XM | 1 |
Fligiel, SE | 1 |
Varani, J | 1 |
Goldhaber, P | 3 |
Hinkle, PM | 1 |
40 other studies available for indomethacin and Fibrosarcoma
Article | Year |
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Embryonal mass and hormone-associated effects of pregnancy inducing a differential growth of four murine tumors.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Estrogens; Female; | 2002 |
Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
Topics: Animals; Aspirin; Diclofenac; Fibrosarcoma; Indomethacin; Liver Neoplasms, Experimental; Neoplasm Tr | 1983 |
Relationships between suppressor macrophages and macrophage precursors in the spleens from tumor-bearing mice.
Topics: Animals; Dinoprostone; Female; Fibrosarcoma; Indomethacin; Isoantibodies; Lymphocyte Activation; Mac | 1984 |
Suppression of polyclonal, tumor cell and alloantigen-induced proliferation: identification of cyclooxygenase pathway dependent and independent mechanisms.
Topics: Animals; Antigens, Neoplasm; Cyclooxygenase Inhibitors; Dinoprostone; Fibrosarcoma; Immune Tolerance | 1984 |
Adherent cells (macrophages?) in tumor-bearing mice suppress MLC responses.
Topics: Animals; Cell Adhesion; Fibrosarcoma; Immunosuppression Therapy; Indomethacin; Lymphocyte Culture Te | 1981 |
Amplification by macrophages of prostaglandin-mediated immunosuppression in mice bearing syngeneic tumors.
Topics: Animals; Antibody Formation; Cell Line; Culture Media; Fibrosarcoma; Immune Tolerance; Indomethacin; | 1984 |
Production of PGE2 and 15-HETE by fibrosarcoma cells.
Topics: Animals; Arachidonic Acid; Aspirin; Calcimycin; Carbon Radioisotopes; Cell Line; Chromatography, Hig | 1995 |
Butylated hydroxyanisole inhibits tumor necrosis factor-induced cytotoxicity and arachidonic acid release.
Topics: Animals; Arachidonic Acid; Butylated Hydroxyanisole; Cell Line; Cell Survival; Cycloheximide; Dactin | 1994 |
Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells.
Topics: Animals; Arachidonic Acid; Caffeine; Collagen; Cyclooxygenase Inhibitors; Dinoprost; Drug Combinatio | 1996 |
[Effect of carrageenan and indomethacin on the growth of a murine fibrosarcoma].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Carrageenan; Female; Fibrosarcoma; In | 2000 |
Tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice.
Topics: Animals; BCG Vaccine; Female; Fibrosarcoma; Immunotherapy; Indomethacin; Male; Mice; Mice, Inbred C3 | 1979 |
Mechanism of inhibition of tumour growth by aspirin and indomethacin.
Topics: Animals; Antibodies, Neoplasm; Aspirin; Female; Fibrosarcoma; Hemolytic Plaque Technique; Immunosupp | 1978 |
Bradykinin-stimulated release of [3H]arachidonic acid from phospholipids of HSDM1C1 cells: comparison of diacyl phospholipids and plasmalogens as sources of prostaglandin precursors.
Topics: Animals; Arachidonic Acids; Bradykinin; Cell Line; Fibrosarcoma; Indomethacin; Mice; Phospholipids; | 1979 |
Inhibition of lymphoma cell proliferation by supernatant from fibrosarcoma cultures: preliminary evidence that the inhibitory material is prostaglandin E.
Topics: Animals; Cell Division; Cells, Cultured; Chromatography, Thin Layer; Culture Media; Depression, Chem | 1977 |
Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells.
Topics: Cell Line; Depression, Chemical; Fibrosarcoma; Hydrocortisone; Indomethacin; Prostaglandins E | 1975 |
Tumor growth changes the contribution of granulocyte-macrophage colony-stimulating factor during macrophage-mediated suppression of allorecognition.
Topics: Animals; Cells, Cultured; Dinoprostone; Fibrosarcoma; Granulocyte-Macrophage Colony-Stimulating Fact | 1992 |
Cytokines and suppressor macrophages cause tumor-bearing host CD8+ T cells to suppress recognition of allogeneic and syngeneic MHC class II molecules.
Topics: Animals; Antibodies, Monoclonal; CD4 Antigens; CD8 Antigens; Cells, Cultured; Dinoprostone; Fibrosar | 1992 |
Effects of n-3 and n-6 fatty acids on tumor necrosis factor cytotoxicity in WEHI fibrosarcoma cells.
Topics: Animals; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Survival; Clone Cells; Dexamethaso | 1992 |
Piroxicam, indomethacin and aspirin action on a murine fibrosarcoma. Effects on tumour-associated and peritoneal macrophages.
Topics: Animals; Antigens, Differentiation; Aspirin; Fibrosarcoma; Glucuronidase; Hematocrit; Indomethacin; | 1991 |
Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle.
Topics: Animals; Cell Cycle; Cholera Toxin; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Dr | 1991 |
Association of increased tumor cell responsiveness to prostaglandin E2 with more aggressive tumor behavior.
Topics: Animals; Cell Line; Cell Movement; Clone Cells; Dinoprostone; Fibrosarcoma; Genetic Variation; Indom | 1991 |
Proliferative response of T cells from tumor-immune chickens to carcinogen-induced fibrosarcoma cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Cell Line; Chickens; Cross Reactions; Fibr | 1990 |
Modulation of alloreactivity by Mac-1+, -2+, and -3+ macrophages from normal and tumor-bearing hosts: flow cytofluorometrically separated macrophages.
Topics: Animals; Antigens, Differentiation; Fibrosarcoma; Flow Cytometry; Fluorescent Antibody Technique; Ga | 1990 |
Splenic natural cytotoxic activity is enhanced during growth of a murine fibrosarcoma.
Topics: Adenocarcinoma; Alprostadil; Animals; Cytotoxicity, Immunologic; Dinoprostone; Fibrosarcoma; Indomet | 1990 |
Dependence of indomethacin-induced potentiation of murine tumor radioresponse on tumor host immunocompetence.
Topics: Animals; Cell Division; Fibrosarcoma; Indomethacin; Mice; Mice, Inbred C3H; Mice, Nude; Radiation-Se | 1990 |
Regression mechanisms of mouse fibrosarcoma cells after in vitro exposure to quercetin: diminution of tumorigenicity with a corresponding decrease in the production of prostaglandin E2.
Topics: Animals; Cross Reactions; Dinoprostone; Female; Fibrosarcoma; Flavonoids; H-2 Antigens; Hematopoieti | 1990 |
Studies of phospholipase and cyclooxygenase activities in herpes simplex virus type 2-transformed rat cells.
Topics: Animals; Cell Line; Cell Transformation, Viral; Cycloheximide; Enzyme Induction; Fibrosarcoma; Herpe | 1989 |
Studies on indomethacin as a potentiator for hyperthermic and radiation responses in a mouse fibrosarcoma.
Topics: Animals; Antineoplastic Agents; Combined Modality Therapy; Fibrosarcoma; Hyperthermia, Induced; Indo | 1989 |
Prostaglandin E2 production by Mac-2+ macrophages: tumor-induced population shift.
Topics: Animals; Antibodies, Monoclonal; Antigens, Surface; Dinoprostone; Fibrosarcoma; Indomethacin; Lympho | 1987 |
Stimulatory effect of epidermal growth factor on prostaglandin E2 production in mouse fibrosarcoma cell line (HSDM1 C1).
Topics: Animals; Cell Line; Dinoprostone; Epidermal Growth Factor; ErbB Receptors; Fibrosarcoma; Indomethaci | 1985 |
Bradykinin-induced cyclic AMP accumulation in mouse fibrosarcoma independent of prostaglandin E2 formation.
Topics: Animals; Bradykinin; Cells, Cultured; Cyclic AMP; Dinoprostone; Fibrosarcoma; Indomethacin; Mice; Pr | 1986 |
Prostaglandin production by murine tumors as a predictor for therapeutic response to indomethacin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Biomarkers, Tumor; Carbo | 1988 |
Synergistic therapeutic effect of combination therapy with OK-432 and interferon-alpha or -gamma on Meth-A ascites tumor in BALB/c mice.
Topics: Animals; Biological Products; Cells, Cultured; Combined Modality Therapy; Drug Synergism; Fibrosarco | 1988 |
The effect of indomethacin on the activation and effector function of suppressor cells from tumor-bearing mice.
Topics: Animals; Antibody Formation; Cells, Cultured; Drug Administration Schedule; Fibrosarcoma; Indomethac | 1985 |
Increase in radioresponse of murine tumors by treatment with indomethacin.
Topics: Animals; Cell Survival; Combined Modality Therapy; Female; Fibrosarcoma; Indomethacin; Male; Mice; M | 1988 |
Modulation of tumor cell motility by prostaglandins and inhibitors of prostaglandin synthesis.
Topics: Animals; Arbaprostil; Cell Line; Cell Movement; Dinoprostone; Fibrosarcoma; Ibuprofen; Indomethacin; | 1986 |
Prostaglandins, calcium metabolism and cancer.
Topics: Animals; Aspirin; Bone and Bones; Bone Resorption; Calcium; Calcium Radioisotopes; Cells, Cultured; | 1974 |
Evidence that the bone resorption-stimulating factor produced by mouse fibrosarcoma cells is prostaglandin E 2 . A new model for the hypercalcemia of cancer.
Topics: Animals; Bone Neoplasms; Bone Resorption; Calcium; Cells, Cultured; Clone Cells; Culture Techniques; | 1972 |
Successful treatment of hypercalcemia by indomethacin in mice bearing a prostaglandin-producing fibrosarcoma.
Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Bone Resorption; Calcium; Calcium Isot | 1973 |
Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin.
Topics: Adrenal Glands; Animals; Antigens; Aspirin; Borohydrides; Clone Cells; Culture Media; Fibroblasts; F | 1972 |