indomethacin and Fetal Death studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.

Research Excerpts

Excerpt	Relevance	Reference
"Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus."	7.69	Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994)
"A case of severe fetal congestive heart failure due to occlusion of the ductus arteriosus in a mother treated with indomethacin for polyhydramnios and premature contractions is described."	7.69	In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. ( Achiron, R; Berant, M; Hegesh, J; Kidron, D; Lipitz, S; Rotstein, Z, 1996)
"Eight gravidas with symptomatic polyhydramnios were managed with maternal indomethacin therapy."	7.68	Indomethacin therapy in the treatment of symptomatic polyhydramnios. ( Kirshon, B; Mari, G; Moise, KJ, 1990)
"When Indomethacin in a dosage of 175 mg/day was used to treat threatened premature labour more than 70% of cases carried on until 37 weeks."	6.37	[Value and dangers of indomethacin used in pregnancy. Apropos of 304 treated patients]. ( Barrat, J; Bouillie, J; Boyer, F; Keskes, J; Marpeau, L; Pigné, A; Vincenti, O, 1988)
"To investigate the effect of cervical application of nonselective and selective inhibitors of nitric oxide synthases--N-nitro-L-arginine methyl ester, L-N-iminoethyl-lysine, and aminoguanidine--as well as inhibitors of cyclooxygenases--indomethacin, and nimesulide--on timing of delivery and fetal death and disease in pregnant rats."	3.71	The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats. ( Bukowski, R; Garfield, RE; McKay, L; Saade, GR; Shi, SQ, 2001)
"Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus."	3.69	Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994)
"A case of severe fetal congestive heart failure due to occlusion of the ductus arteriosus in a mother treated with indomethacin for polyhydramnios and premature contractions is described."	3.69	In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. ( Achiron, R; Berant, M; Hegesh, J; Kidron, D; Lipitz, S; Rotstein, Z, 1996)
"Eight gravidas with symptomatic polyhydramnios were managed with maternal indomethacin therapy."	3.68	Indomethacin therapy in the treatment of symptomatic polyhydramnios. ( Kirshon, B; Mari, G; Moise, KJ, 1990)
"Indomethacin was significantly more effective than placebo in inhibition of premature labor during a 24-hour course of therapy, with treatment failure during therapy occurring in only one of 15 indomethacin-treated patients compared to nine of 15 placebo-treated patients (p less than 0."	2.65	The inhibition of premature labor with indomethacin. ( Blake, DA; Dubin, NH; Egner, PG; Kumor, KM; Niebyl, JR; Robinson, JC; White, RD, 1980)
" The first treatment consisted of the administration of ritodrine and a placebo; in the second, ritodrine was combined with indomethacin."	2.64	A study of indomethacin combined with ritodrine in threatened preterm labor. ( Cañas, E; Cararach, V; Edo, A; Gamissans, O; Puerto, B; Ribas, J, 1978)
"When Indomethacin in a dosage of 175 mg/day was used to treat threatened premature labour more than 70% of cases carried on until 37 weeks."	2.37	[Value and dangers of indomethacin used in pregnancy. Apropos of 304 treated patients]. ( Barrat, J; Bouillie, J; Boyer, F; Keskes, J; Marpeau, L; Pigné, A; Vincenti, O, 1988)
"When pregnancy is continued after death of one fetus in monochorionic twin pregnancy, the surviving fetus sometimes exhibits intrauterine death or brain damage."	1.30	Hysterotomy and selective delivery of an intrauterine dead fetus to prevent intrauterine death or brain damage of the surviving fetus in monochorionic twin pregnancy. ( Ito, T; Kadowaki, K; Makio, A; Nagata, N; Takahashi, H; Terakawa, N, 1997)
"Pretreatment with indomethacin significantly decreased the proportion of fetal death from 83% to < 25% in mice injected with 10 micrograms of LPS."	1.29	Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. ( Branch, DW; Dudley, DJ; Edwin, SS; Mitchell, MD; Silver, RM; Simmons, DL; Trautman, MS, 1995)
"In the three cases of severe twin-to-twin transfusion syndrome no reduction of amniotic fluid in either sac was demonstrated."	1.29	Indomethacin in severe twin-to-twin transfusion syndrome. ( Cetrulo, CL; D'Alton, ME; Dilillo, L; Jones, JM; Sbarra, AJ, 1993)
"Indomethacin (Id) treatment of rabbits at the time of implantation resulted in a significant reduction in the number of viable embryos as well as significant reduction in plasma progesterone concentrations."	1.27	Treatment with prostaglandins reduces the antifertility effect of indomethacin in rabbits. ( el-Banna, AA, 1986)
"A case of hydrops fetalis with intra-uterine death after premature closure of the ductus arteriosus because of inhibition of premature labour by the administration of indomethacin is presented."	1.27	Premature closure of the ductus arteriosus causing intra-uterine death. A case report. ( Coetzee, MJ; Franszen, S; Truter, PJ; van der Merwe, JV, 1986)

Research

Studies (32)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

Fetal Outcome 4 - Incidence of Fetal Loss

Fetal Outcome 5 - Incidence of Spontaneous Abortion

Fetal Outcome 6 - Incidence of All Stillbirth

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (65.63)	18.7374
1990's	9 (28.13)	18.2507
2000's	2 (6.25)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Parfenova, H	1
Levine, V	1
Gunther, WM	1
Pourcyrous, M	1
Leffler, CW	1
Skosyreva, AM	1
Khachapuridze, NV	1
Golovanova, IV	1
Harrison, MR	1
Anderson, J	1
Rosen, MA	1
Ross, NA	1
Hendrickx, AG	1
Nara, BS	1
First, NL	1
Niebyl, JR	1
Blake, DA	1
White, RD	1
Kumor, KM	1
Dubin, NH	1
Robinson, JC	1
Egner, PG	1
Itskovitz, J	1
Abramovici, H	1
Brandes, JM	1
Harris, WH	1
Marks, TA	1
Tracy, DE	1
Silver, RM	2
Edwin, SS	2
Trautman, MS	1
Simmons, DL	1
Branch, DW	2
Dudley, DJ	2
Mitchell, MD	2
van der Heijden, BJ	1
Carlus, C	1
Narcy, F	1
Bavoux, F	1
Delezoide, AL	1
Gubler, MC	1
Jones, JM	1
Sbarra, AJ	1
Dilillo, L	1
Cetrulo, CL	1
D'Alton, ME	1
Achiron, R	1
Lipitz, S	1
Kidron, D	1
Berant, M	1
Hegesh, J	1
Rotstein, Z	1
Umar, F	1
Ito, T	1
Kadowaki, K	1
Takahashi, H	1
Nagata, N	1
Makio, A	1
Terakawa, N	1
Bukowski, R	1
McKay, L	1
Shi, SQ	1
Saade, GR	1
Garfield, RE	1
Sharpe, GL	1
Krous, H	1
Altshuler, G	1
Karim, SM	1
Gamissans, O	1
Cañas, E	1
Cararach, V	1
Ribas, J	1
Puerto, B	1
Edo, A	1
Kamel, S	1
Wood, GW	1
Kirshon, B	1
Mari, G	1
Moise, KJ	1
Guthrie, HD	1
el-Banna, AA	1
Marpeau, L	1
Keskes, J	1
Vincenti, O	1
Boyer, F	1
Bouillie, J	1
Pigné, A	1
Barrat, J	1
Randall, CL	1
Anton, RF	1
Becker, HC	1
Truter, PJ	1
Franszen, S	1
van der Merwe, JV	1
Coetzee, MJ	1
Persaud, TV	3
Moore, KL	2
Aiken, JW	1
Chester, R	1
Dukes, M	1
Slater, SR	1
Walpole, AL	1
Skarnes, RC	2
Harper, MJ	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
Vaginal Indomethacin Versus Oral Nifedipine for Preterm Labor; a Randomized Controlled Trial[NCT04404686]	Phase 2/Phase 3	300 participants (Anticipated)	Interventional	2020-10-31	Not yet recruiting
Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361]	Early Phase 1	0 participants (Actual)	Interventional	2020-08-01	Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.)
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680]		11,976 participants (Actual)	Interventional	2016-03-23	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
Intervention Arm	189
Placebo Arm	230

Intervention	Participants (Count of Participants)
Intervention Arm	1078
Placebo Arm	1153

Intervention	Participants (Count of Participants)
Intervention Arm	78
Placebo Arm	101

Intervention	Participants (Count of Participants)
Intervention Arm	303
Placebo Arm	353

Intervention	Participants (Count of Participants)
Intervention Arm	134
Placebo Arm	152

Intervention	Participants (Count of Participants)
Intervention Arm	141
Placebo Arm	166

- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery

Incidence of Hypertensive Disorders of Pregnancy

Intervention	Participants (Count of Participants)
Intervention Arm	42
Placebo Arm	30

- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)

Incidence of Perinatal Mortality

Intervention	Participants (Count of Participants)
Intervention Arm	352
Placebo Arm	325

- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Incidence of Preterm Birth

Intervention	Participants (Count of Participants)
Intervention Arm	264
Placebo Arm	309

The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery

Incidence of Small for Gestational Age (SGA)

Intervention	Participants (Count of Participants)
Intervention Arm	668
Placebo Arm	754

- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 1 - Incidence of Vaginal Bleeding

Intervention	Participants (Count of Participants)
Intervention Arm	1506
Placebo Arm	1564

- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

Intervention	Participants (Count of Participants)
Intervention Arm	214
Placebo Arm	246

- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

Intervention	Participants (Count of Participants)
Intervention Arm	26
Placebo Arm	25

- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 4 - Incidence of Maternal Mortality

Intervention	Participants (Count of Participants)
Intervention Arm	54
Placebo Arm	43

- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 5 - Incidence of Late Abortion

Intervention	Participants (Count of Participants)
Intervention Arm	9
Placebo Arm	12

- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 6 - Change in Maternal Hemoglobin

Intervention	Participants (Count of Participants)
Intervention Arm	23
Placebo Arm	30

Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Intervention	Participants (Count of Participants)
Intervention Arm	290
Placebo Arm	333

Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Article	Year
On the use of blockers of prostaglandin synthesis in the control of labor. Advances in prostaglandin and thromboxane research, 1978, Volume: 4 Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome	1978
Control of time of parturition in pigs. Journal of reproduction and fertility. Supplement, 1985, Volume: 33 Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Animal Husbandry; Animals; Dinoprost; Fema	1985
[Value and dangers of indomethacin used in pregnancy. Apropos of 304 treated patients]. Journal de gynecologie, obstetrique et biologie de la reproduction, 1988, Volume: 17, Issue:1 Topics: Abortion, Threatened; Acute Kidney Injury; Ductus Arteriosus, Patent; Female; Fetal Death; Fetus; Hu	1988

Article	Year
The inhibition of premature labor with indomethacin. American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8 Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans	1980
The inhibition of premature labor with indomethacin. American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8 Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans	1980
The inhibition of premature labor with indomethacin. American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8 Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans	1980
The inhibition of premature labor with indomethacin. American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8 Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans	1980
On the use of blockers of prostaglandin synthesis in the control of labor. Advances in prostaglandin and thromboxane research, 1978, Volume: 4 Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome	1978
A study of indomethacin combined with ritodrine in threatened preterm labor. European journal of obstetrics, gynecology, and reproductive biology, 1978, Volume: 8, Issue:3 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Fetal Death	1978

Article	Year
COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells. Pediatric research, 2002, Volume: 52, Issue:3 Topics: Animals; Cells, Cultured; Cerebrovascular Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyg	2002
[Action of indomethacin on fetal development]. Akusherstvo i ginekologiia, 1984, Issue:6 Topics: Animals; Dose-Response Relationship, Drug; Embryo Implantation; Female; Fetal Death; Fetus; Indometh	1984
Fetal surgery in the primate I. Anesthetic, surgical, and tocolytic management to maximize fetal-neonatal survival. Journal of pediatric surgery, 1982, Volume: 17, Issue:2 Topics: Anesthetics; Animals; Female; Fetal Death; Fetal Viability; Fetus; Indomethacin; Macaca; Macaca fasc	1982
Effect of indomethacin and prostaglandin F2 alpha on parturition in swine. Journal of animal science, 1981, Volume: 52, Issue:6 Topics: Animals; Corpus Luteum; Female; Fetal Death; Indomethacin; Labor, Obstetric; Pregnancy; Progesterone	1981
Oligohydramnion, meconium and perinatal death concurrent with indomethacin treatment in human pregnancy. The Journal of reproductive medicine, 1980, Volume: 24, Issue:3 Topics: Adult; Amniotic Fluid; Female; Fetal Death; Humans; Indomethacin; Infant Mortality; Infant, Newborn;	1980
The effects of repeated doses of indomethacin on fetal rabbit mortality and on the patency of the ductus arteriosus. Canadian journal of physiology and pharmacology, 1980, Volume: 58, Issue:2 Topics: Animals; Constriction, Pathologic; Ductus Arteriosus; Female; Fetal Death; Fetus; Indomethacin; Mate	1980
Prevention of human recombinant interleukin-1 beta (rhIL-1 beta) embryolethality with progesterone or indomethacin. American journal of reproductive immunology (New York, N.Y. : 1989), 1995, Volume: 33, Issue:4 Topics: Adjuvants, Immunologic; Animals; Cytosine; Drug Interactions; Female; Fetal Death; Indomethacin; Int	1995
Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. The Journal of clinical investigation, 1995, Volume: 95, Issue:2 Topics: Abortion, Spontaneous; Animals; Bacterial Infections; Decidua; Dose-Response Relationship, Drug; Enz	1995
Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. American journal of obstetrics and gynecology, 1994, Volume: 171, Issue:3 Topics: Adult; Anuria; Dilatation, Pathologic; Female; Fetal Death; Humans; Immunohistochemistry; Indomethac	1994
Indomethacin in severe twin-to-twin transfusion syndrome. American journal of perinatology, 1993, Volume: 10, Issue:1 Topics: Adult; Female; Fetal Death; Fetofetal Transfusion; Humans; Indomethacin; Infant Mortality; Infant, N	1993
In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. Prenatal diagnosis, 1996, Volume: 16, Issue:7 Topics: Adult; Autopsy; Female; Fetal Death; Heart Failure; Heart Septum; Humans; Indomethacin; Obstetric La	1996
Bacterial lipopolysaccharide-mediated murine fetal death: the role of interleukin-1. American journal of obstetrics and gynecology, 1997, Volume: 176, Issue:3 Topics: Animals; Antibodies; Dinoprostone; Female; Fetal Death; Indomethacin; Interleukin-1; Lipopolysacchar	1997
Hysterotomy and selective delivery of an intrauterine dead fetus to prevent intrauterine death or brain damage of the surviving fetus in monochorionic twin pregnancy. Journal of perinatal medicine, 1997, Volume: 25, Issue:1 Topics: Adult; Delivery, Obstetric; Diseases in Twins; Female; Fetal Death; Gestational Age; Humans; Indomet	1997
The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats. American journal of obstetrics and gynecology, 2001, Volume: 185, Issue:4 Topics: Administration, Topical; Animals; Cervical Ripening; Cervix Uteri; Cyclooxygenase Inhibitors; Delive	2001
Perinatal use of indomethacin. Lancet (London, England), 1977, Jul-09, Volume: 2, Issue:8028 Topics: Animals; Female; Fetal Death; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Rats	1977
Failure of in vitro-expanded hyperimmune cytotoxic T lymphocytes to affect survival of mouse embryos in vivo. Journal of reproductive immunology, 1991, Volume: 19, Issue:1 Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Fetal Death; Graft Survival; Immune Tolerance;	1991
Indomethacin therapy in the treatment of symptomatic polyhydramnios. Obstetrics and gynecology, 1990, Volume: 75, Issue:2 Topics: Adult; Amniocentesis; Diuresis; Female; Fetal Death; Fetal Monitoring; Fetus; Gestational Age; Human	1990
Treatment with prostaglandins reduces the antifertility effect of indomethacin in rabbits. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1986, Volume: 85, Issue:1 Topics: Animals; Embryo Implantation; Female; Fertility; Fetal Death; Indomethacin; Pregnancy; Progesterone;	1986
Effect of indomethacin on alcohol-induced morphological anomalies in mice. Life sciences, 1987, Jul-20, Volume: 41, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Ethanol; Female; Fertility; Fetal Death; Indometh	1987
Premature closure of the ductus arteriosus causing intra-uterine death. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Oct-25, Volume: 70, Issue:9 Topics: Adult; Ductus Arteriosus; Edema; Female; Fetal Death; Humans; Indomethacin; Obstetric Labor, Prematu	1986
Letter: Inhibitors of prostaglandin synthesis and fetal development. Lancet (London, England), 1974, Jan-19, Volume: 1, Issue:7847 Topics: Animals; Cell Differentiation; Female; Fetal Death; Fetus; Gestational Age; Indomethacin; Mice; Preg	1974
Inhibitors of prostaglandin synthesis during pregnancy. 1. Embryopathic activity of indomethacin in mice. Anatomischer Anzeiger, 1974, Volume: 136, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetal Diseases; Fetus; Gestational Age; I	1974
Inhibitors of prostaglandin synthesis during pregnancy. 2. The effects of indomethacin in pregnant rats. Anatomischer Anzeiger, 1974, Volume: 136, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetal Diseases; Fetus; Growth; Indomethac	1974
Aspirin and indomethacin prolong parturition in rats: evidence that prostaglandins contribute to expulsion of fetus. Nature, 1972, Nov-03, Volume: 240, Issue:5375 Topics: Administration, Oral; Animals; Aspirin; Biological Assay; Chickens; Chromatography, Thin Layer; Fema	1972
Delay of parturition in the rat by anti-inflammatory agents which inhibit the biosynthesis of prostaglandins. Nature, 1972, Nov-03, Volume: 240, Issue:5375 Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Cortisone; Depression, C	1972
Relationship between endotoxin-induced abortion and the synthesis of prostaglandin F. Prostaglandins, 1972, Volume: 1, Issue:3 Topics: Abortion, Induced; Animals; Diarrhea; Dose-Response Relationship, Drug; Drug Interactions; Endotoxin	1972
The role of prostaglandin in endotoxin-induced abortion and fetal death. Advances in the biosciences, 1973, Volume: 9 Topics: Abortion, Induced; Animals; Cyproheptadine; Depression, Chemical; Endotoxins; Female; Fetal Death; H	1973

indomethacin and Fetal Death