Page last updated: 2024-10-29

indomethacin and Fetal Death

indomethacin has been researched along with Fetal Death in 32 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.

Research Excerpts

ExcerptRelevanceReference
"Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus."7.69Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994)
"A case of severe fetal congestive heart failure due to occlusion of the ductus arteriosus in a mother treated with indomethacin for polyhydramnios and premature contractions is described."7.69In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. ( Achiron, R; Berant, M; Hegesh, J; Kidron, D; Lipitz, S; Rotstein, Z, 1996)
"Eight gravidas with symptomatic polyhydramnios were managed with maternal indomethacin therapy."7.68Indomethacin therapy in the treatment of symptomatic polyhydramnios. ( Kirshon, B; Mari, G; Moise, KJ, 1990)
"When Indomethacin in a dosage of 175 mg/day was used to treat threatened premature labour more than 70% of cases carried on until 37 weeks."6.37[Value and dangers of indomethacin used in pregnancy. Apropos of 304 treated patients]. ( Barrat, J; Bouillie, J; Boyer, F; Keskes, J; Marpeau, L; Pigné, A; Vincenti, O, 1988)
"To investigate the effect of cervical application of nonselective and selective inhibitors of nitric oxide synthases--N-nitro-L-arginine methyl ester, L-N-iminoethyl-lysine, and aminoguanidine--as well as inhibitors of cyclooxygenases--indomethacin, and nimesulide--on timing of delivery and fetal death and disease in pregnant rats."3.71The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats. ( Bukowski, R; Garfield, RE; McKay, L; Saade, GR; Shi, SQ, 2001)
"Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus."3.69Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994)
"A case of severe fetal congestive heart failure due to occlusion of the ductus arteriosus in a mother treated with indomethacin for polyhydramnios and premature contractions is described."3.69In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale. ( Achiron, R; Berant, M; Hegesh, J; Kidron, D; Lipitz, S; Rotstein, Z, 1996)
"Eight gravidas with symptomatic polyhydramnios were managed with maternal indomethacin therapy."3.68Indomethacin therapy in the treatment of symptomatic polyhydramnios. ( Kirshon, B; Mari, G; Moise, KJ, 1990)
"Indomethacin was significantly more effective than placebo in inhibition of premature labor during a 24-hour course of therapy, with treatment failure during therapy occurring in only one of 15 indomethacin-treated patients compared to nine of 15 placebo-treated patients (p less than 0."2.65The inhibition of premature labor with indomethacin. ( Blake, DA; Dubin, NH; Egner, PG; Kumor, KM; Niebyl, JR; Robinson, JC; White, RD, 1980)
" The first treatment consisted of the administration of ritodrine and a placebo; in the second, ritodrine was combined with indomethacin."2.64A study of indomethacin combined with ritodrine in threatened preterm labor. ( Cañas, E; Cararach, V; Edo, A; Gamissans, O; Puerto, B; Ribas, J, 1978)
"When Indomethacin in a dosage of 175 mg/day was used to treat threatened premature labour more than 70% of cases carried on until 37 weeks."2.37[Value and dangers of indomethacin used in pregnancy. Apropos of 304 treated patients]. ( Barrat, J; Bouillie, J; Boyer, F; Keskes, J; Marpeau, L; Pigné, A; Vincenti, O, 1988)
"When pregnancy is continued after death of one fetus in monochorionic twin pregnancy, the surviving fetus sometimes exhibits intrauterine death or brain damage."1.30Hysterotomy and selective delivery of an intrauterine dead fetus to prevent intrauterine death or brain damage of the surviving fetus in monochorionic twin pregnancy. ( Ito, T; Kadowaki, K; Makio, A; Nagata, N; Takahashi, H; Terakawa, N, 1997)
"Pretreatment with indomethacin significantly decreased the proportion of fetal death from 83% to < 25% in mice injected with 10 micrograms of LPS."1.29Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. ( Branch, DW; Dudley, DJ; Edwin, SS; Mitchell, MD; Silver, RM; Simmons, DL; Trautman, MS, 1995)
"In the three cases of severe twin-to-twin transfusion syndrome no reduction of amniotic fluid in either sac was demonstrated."1.29Indomethacin in severe twin-to-twin transfusion syndrome. ( Cetrulo, CL; D'Alton, ME; Dilillo, L; Jones, JM; Sbarra, AJ, 1993)
"Indomethacin (Id) treatment of rabbits at the time of implantation resulted in a significant reduction in the number of viable embryos as well as significant reduction in plasma progesterone concentrations."1.27Treatment with prostaglandins reduces the antifertility effect of indomethacin in rabbits. ( el-Banna, AA, 1986)
"A case of hydrops fetalis with intra-uterine death after premature closure of the ductus arteriosus because of inhibition of premature labour by the administration of indomethacin is presented."1.27Premature closure of the ductus arteriosus causing intra-uterine death. A case report. ( Coetzee, MJ; Franszen, S; Truter, PJ; van der Merwe, JV, 1986)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199021 (65.63)18.7374
1990's9 (28.13)18.2507
2000's2 (6.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Parfenova, H1
Levine, V1
Gunther, WM1
Pourcyrous, M1
Leffler, CW1
Skosyreva, AM1
Khachapuridze, NV1
Golovanova, IV1
Harrison, MR1
Anderson, J1
Rosen, MA1
Ross, NA1
Hendrickx, AG1
Nara, BS1
First, NL1
Niebyl, JR1
Blake, DA1
White, RD1
Kumor, KM1
Dubin, NH1
Robinson, JC1
Egner, PG1
Itskovitz, J1
Abramovici, H1
Brandes, JM1
Harris, WH1
Marks, TA1
Tracy, DE1
Silver, RM2
Edwin, SS2
Trautman, MS1
Simmons, DL1
Branch, DW2
Dudley, DJ2
Mitchell, MD2
van der Heijden, BJ1
Carlus, C1
Narcy, F1
Bavoux, F1
Delezoide, AL1
Gubler, MC1
Jones, JM1
Sbarra, AJ1
Dilillo, L1
Cetrulo, CL1
D'Alton, ME1
Achiron, R1
Lipitz, S1
Kidron, D1
Berant, M1
Hegesh, J1
Rotstein, Z1
Umar, F1
Ito, T1
Kadowaki, K1
Takahashi, H1
Nagata, N1
Makio, A1
Terakawa, N1
Bukowski, R1
McKay, L1
Shi, SQ1
Saade, GR1
Garfield, RE1
Sharpe, GL1
Krous, H1
Altshuler, G1
Karim, SM1
Gamissans, O1
Cañas, E1
Cararach, V1
Ribas, J1
Puerto, B1
Edo, A1
Kamel, S1
Wood, GW1
Kirshon, B1
Mari, G1
Moise, KJ1
Guthrie, HD1
el-Banna, AA1
Marpeau, L1
Keskes, J1
Vincenti, O1
Boyer, F1
Bouillie, J1
Pigné, A1
Barrat, J1
Randall, CL1
Anton, RF1
Becker, HC1
Truter, PJ1
Franszen, S1
van der Merwe, JV1
Coetzee, MJ1
Persaud, TV3
Moore, KL2
Aiken, JW1
Chester, R1
Dukes, M1
Slater, SR1
Walpole, AL1
Skarnes, RC2
Harper, MJ2

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Vaginal Indomethacin Versus Oral Nifedipine for Preterm Labor; a Randomized Controlled Trial[NCT04404686]Phase 2/Phase 3300 participants (Anticipated)Interventional2020-10-31Not yet recruiting
Randomized, Placebo Controlled Trial of Indomethacin for Tocolysis[NCT01869361]Early Phase 10 participants (Actual)Interventional2020-08-01Withdrawn (stopped due to Due to much lower than expected numbers of eligible patients and lack of PI time, the study was not started.)
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680]11,976 participants (Actual)Interventional2016-03-23Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm189
Placebo Arm230

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

- Birth weight <2500g (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm1078
Placebo Arm1153

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

- Birth weight <1500g (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm78
Placebo Arm101

Fetal Outcome 4 - Incidence of Fetal Loss

- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm303
Placebo Arm353

Fetal Outcome 5 - Incidence of Spontaneous Abortion

- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm134
Placebo Arm152

Fetal Outcome 6 - Incidence of All Stillbirth

- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm141
Placebo Arm166

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm42
Placebo Arm30

Incidence of Hypertensive Disorders of Pregnancy

- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)

InterventionParticipants (Count of Participants)
Intervention Arm352
Placebo Arm325

Incidence of Perinatal Mortality

- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm264
Placebo Arm309

Incidence of Preterm Birth

The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm668
Placebo Arm754

Incidence of Small for Gestational Age (SGA)

- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm1506
Placebo Arm1564

Maternal Outcome 1 - Incidence of Vaginal Bleeding

- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm214
Placebo Arm246

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm26
Placebo Arm25

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm54
Placebo Arm43

Maternal Outcome 4 - Incidence of Maternal Mortality

- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm9
Placebo Arm12

Maternal Outcome 5 - Incidence of Late Abortion

- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm23
Placebo Arm30

Maternal Outcome 6 - Change in Maternal Hemoglobin

Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.

InterventionParticipants (Count of Participants)
Intervention Arm290
Placebo Arm333

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm8
Placebo Arm21

Reviews

3 reviews available for indomethacin and Fetal Death

ArticleYear
On the use of blockers of prostaglandin synthesis in the control of labor.
    Advances in prostaglandin and thromboxane research, 1978, Volume: 4

    Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome

1978
Control of time of parturition in pigs.
    Journal of reproduction and fertility. Supplement, 1985, Volume: 33

    Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Animal Husbandry; Animals; Dinoprost; Fema

1985
[Value and dangers of indomethacin used in pregnancy. Apropos of 304 treated patients].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1988, Volume: 17, Issue:1

    Topics: Abortion, Threatened; Acute Kidney Injury; Ductus Arteriosus, Patent; Female; Fetal Death; Fetus; Hu

1988

Trials

3 trials available for indomethacin and Fetal Death

ArticleYear
The inhibition of premature labor with indomethacin.
    American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8

    Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans

1980
The inhibition of premature labor with indomethacin.
    American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8

    Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans

1980
The inhibition of premature labor with indomethacin.
    American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8

    Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans

1980
The inhibition of premature labor with indomethacin.
    American journal of obstetrics and gynecology, 1980, Apr-15, Volume: 136, Issue:8

    Topics: Dinoprost; Double-Blind Method; Drug Evaluation; Estradiol; Female; Fetal Blood; Fetal Death; Humans

1980
On the use of blockers of prostaglandin synthesis in the control of labor.
    Advances in prostaglandin and thromboxane research, 1978, Volume: 4

    Topics: Animals; Aspirin; Clinical Trials as Topic; Female; Fetal Death; Fetus; Hemodynamics; Humans; Indome

1978
A study of indomethacin combined with ritodrine in threatened preterm labor.
    European journal of obstetrics, gynecology, and reproductive biology, 1978, Volume: 8, Issue:3

    Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Fetal Death

1978

Other Studies

27 other studies available for indomethacin and Fetal Death

ArticleYear
COX-1 and COX-2 contributions to basal and IL-1 beta-stimulated prostanoid synthesis in human neonatal cerebral microvascular endothelial cells.
    Pediatric research, 2002, Volume: 52, Issue:3

    Topics: Animals; Cells, Cultured; Cerebrovascular Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyg

2002
[Action of indomethacin on fetal development].
    Akusherstvo i ginekologiia, 1984, Issue:6

    Topics: Animals; Dose-Response Relationship, Drug; Embryo Implantation; Female; Fetal Death; Fetus; Indometh

1984
Fetal surgery in the primate I. Anesthetic, surgical, and tocolytic management to maximize fetal-neonatal survival.
    Journal of pediatric surgery, 1982, Volume: 17, Issue:2

    Topics: Anesthetics; Animals; Female; Fetal Death; Fetal Viability; Fetus; Indomethacin; Macaca; Macaca fasc

1982
Effect of indomethacin and prostaglandin F2 alpha on parturition in swine.
    Journal of animal science, 1981, Volume: 52, Issue:6

    Topics: Animals; Corpus Luteum; Female; Fetal Death; Indomethacin; Labor, Obstetric; Pregnancy; Progesterone

1981
Oligohydramnion, meconium and perinatal death concurrent with indomethacin treatment in human pregnancy.
    The Journal of reproductive medicine, 1980, Volume: 24, Issue:3

    Topics: Adult; Amniotic Fluid; Female; Fetal Death; Humans; Indomethacin; Infant Mortality; Infant, Newborn;

1980
The effects of repeated doses of indomethacin on fetal rabbit mortality and on the patency of the ductus arteriosus.
    Canadian journal of physiology and pharmacology, 1980, Volume: 58, Issue:2

    Topics: Animals; Constriction, Pathologic; Ductus Arteriosus; Female; Fetal Death; Fetus; Indomethacin; Mate

1980
Prevention of human recombinant interleukin-1 beta (rhIL-1 beta) embryolethality with progesterone or indomethacin.
    American journal of reproductive immunology (New York, N.Y. : 1989), 1995, Volume: 33, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Cytosine; Drug Interactions; Female; Fetal Death; Indomethacin; Int

1995
Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide.
    The Journal of clinical investigation, 1995, Volume: 95, Issue:2

    Topics: Abortion, Spontaneous; Animals; Bacterial Infections; Decidua; Dose-Response Relationship, Drug; Enz

1995
Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin.
    American journal of obstetrics and gynecology, 1994, Volume: 171, Issue:3

    Topics: Adult; Anuria; Dilatation, Pathologic; Female; Fetal Death; Humans; Immunohistochemistry; Indomethac

1994
Indomethacin in severe twin-to-twin transfusion syndrome.
    American journal of perinatology, 1993, Volume: 10, Issue:1

    Topics: Adult; Female; Fetal Death; Fetofetal Transfusion; Humans; Indomethacin; Infant Mortality; Infant, N

1993
In utero congestive heart failure due to maternal indomethacin treatment for polyhydramnios and premature labour in a fetus with antenatal closure of the foramen ovale.
    Prenatal diagnosis, 1996, Volume: 16, Issue:7

    Topics: Adult; Autopsy; Female; Fetal Death; Heart Failure; Heart Septum; Humans; Indomethacin; Obstetric La

1996
Bacterial lipopolysaccharide-mediated murine fetal death: the role of interleukin-1.
    American journal of obstetrics and gynecology, 1997, Volume: 176, Issue:3

    Topics: Animals; Antibodies; Dinoprostone; Female; Fetal Death; Indomethacin; Interleukin-1; Lipopolysacchar

1997
Hysterotomy and selective delivery of an intrauterine dead fetus to prevent intrauterine death or brain damage of the surviving fetus in monochorionic twin pregnancy.
    Journal of perinatal medicine, 1997, Volume: 25, Issue:1

    Topics: Adult; Delivery, Obstetric; Diseases in Twins; Female; Fetal Death; Gestational Age; Humans; Indomet

1997
The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats.
    American journal of obstetrics and gynecology, 2001, Volume: 185, Issue:4

    Topics: Administration, Topical; Animals; Cervical Ripening; Cervix Uteri; Cyclooxygenase Inhibitors; Delive

2001
Perinatal use of indomethacin.
    Lancet (London, England), 1977, Jul-09, Volume: 2, Issue:8028

    Topics: Animals; Female; Fetal Death; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Rats

1977
Failure of in vitro-expanded hyperimmune cytotoxic T lymphocytes to affect survival of mouse embryos in vivo.
    Journal of reproductive immunology, 1991, Volume: 19, Issue:1

    Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Fetal Death; Graft Survival; Immune Tolerance;

1991
Indomethacin therapy in the treatment of symptomatic polyhydramnios.
    Obstetrics and gynecology, 1990, Volume: 75, Issue:2

    Topics: Adult; Amniocentesis; Diuresis; Female; Fetal Death; Fetal Monitoring; Fetus; Gestational Age; Human

1990
Treatment with prostaglandins reduces the antifertility effect of indomethacin in rabbits.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1986, Volume: 85, Issue:1

    Topics: Animals; Embryo Implantation; Female; Fertility; Fetal Death; Indomethacin; Pregnancy; Progesterone;

1986
Effect of indomethacin on alcohol-induced morphological anomalies in mice.
    Life sciences, 1987, Jul-20, Volume: 41, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Ethanol; Female; Fertility; Fetal Death; Indometh

1987
Premature closure of the ductus arteriosus causing intra-uterine death. A case report.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Oct-25, Volume: 70, Issue:9

    Topics: Adult; Ductus Arteriosus; Edema; Female; Fetal Death; Humans; Indomethacin; Obstetric Labor, Prematu

1986
Letter: Inhibitors of prostaglandin synthesis and fetal development.
    Lancet (London, England), 1974, Jan-19, Volume: 1, Issue:7847

    Topics: Animals; Cell Differentiation; Female; Fetal Death; Fetus; Gestational Age; Indomethacin; Mice; Preg

1974
Inhibitors of prostaglandin synthesis during pregnancy. 1. Embryopathic activity of indomethacin in mice.
    Anatomischer Anzeiger, 1974, Volume: 136, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetal Diseases; Fetus; Gestational Age; I

1974
Inhibitors of prostaglandin synthesis during pregnancy. 2. The effects of indomethacin in pregnant rats.
    Anatomischer Anzeiger, 1974, Volume: 136, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetal Diseases; Fetus; Growth; Indomethac

1974
Aspirin and indomethacin prolong parturition in rats: evidence that prostaglandins contribute to expulsion of fetus.
    Nature, 1972, Nov-03, Volume: 240, Issue:5375

    Topics: Administration, Oral; Animals; Aspirin; Biological Assay; Chickens; Chromatography, Thin Layer; Fema

1972
Delay of parturition in the rat by anti-inflammatory agents which inhibit the biosynthesis of prostaglandins.
    Nature, 1972, Nov-03, Volume: 240, Issue:5375

    Topics: Acetates; Administration, Oral; Animals; Anti-Inflammatory Agents; Aspirin; Cortisone; Depression, C

1972
Relationship between endotoxin-induced abortion and the synthesis of prostaglandin F.
    Prostaglandins, 1972, Volume: 1, Issue:3

    Topics: Abortion, Induced; Animals; Diarrhea; Dose-Response Relationship, Drug; Drug Interactions; Endotoxin

1972
The role of prostaglandin in endotoxin-induced abortion and fetal death.
    Advances in the biosciences, 1973, Volume: 9

    Topics: Abortion, Induced; Animals; Cyproheptadine; Depression, Chemical; Endotoxins; Female; Fetal Death; H

1973