indomethacin has been researched along with Experimental Radiation Injuries in 21 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effect of the prostaglandin synthetase inhibitor indomethacin on radiation induced esophagitis, pneumonitis, and tumor response was evaluated in the C3H mouse." | 7.68 | Protection by indomethacin against acute radiation esophagitis. ( Barnes, M; Glatstein, E; Mitchell, JB; Orr, K; Russo, A; Tochner, Z, 1990) |
| "Indomethacin-treated animals showed no signs or only mild esophagitis posttreatment." | 5.26 | Radiation esophagitis in the opossum: radioprotection with indomethacin. ( Feldman, MS; Libshitz, HI; Mamel, JJ; Northway, MG; Osborne, BM; Szwarc, IA; West, JH, 1980) |
| " To determine the effect of inhibition of prostaglandin synthesis on UVB-induced cataract formation, animals were given indomethacin intraperitoneally." | 3.69 | The role of prostaglandins E2 and F2 alpha in ultraviolet radiation-induced cortical cataracts in vivo. ( Andley, UP; Becker, B; Fritz, C; Morrison, AR, 1996) |
| " The effect of the prostaglandin synthetase inhibitor indomethacin on radiation induced esophagitis, pneumonitis, and tumor response was evaluated in the C3H mouse." | 3.68 | Protection by indomethacin against acute radiation esophagitis. ( Barnes, M; Glatstein, E; Mitchell, JB; Orr, K; Russo, A; Tochner, Z, 1990) |
| " The X-ray-induced ocular inflammation, particularly the rise in intraocular pressure, was found to be inhibited by intravenous pretreatment of rabbits with flurbiprofen, indomethacin, or imidazole (1, 10, and 100 mg/kg i." | 3.66 | The role of the arachidonic acid cascade in the species-specific X-ray-induced inflammation of the rabbit eye. ( Bito, LZ; Klein, EM, 1982) |
| "Indomethacin did not suppress acceleration of repopulation." | 1.30 | Modulation of accelerated repopulation in mouse skin during daily irradiation. ( Heasman, F; Shirazi, A; Trott, KR, 1999) |
| "Indomethacin treated animals demonstrated significantly less polymorphonuclear leukocyte infiltration and decreased degeneration." | 1.28 | The effect of indomethacin on acute radiation induced gastrointestinal injury: a morphologic study. ( Halter, SA; Rose, PG; Su, CM, 1992) |
| " The 5-lipoxygenase inhibitor diethylcarbamazine and the LTD4/LTE4 receptor antagonist LY 171883 markedly reduced mortality in dose-response fashion." | 1.28 | Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis. ( Gross, NJ; Holloway, NO; Narine, KR, 1991) |
| "Treatment with indomethacin and diclofenac sodium was found to increase granulocyte counts in the blood of sublethally gamma-irradiated mice." | 1.28 | Effect of indomethacin, diclofenac sodium and sodium salicylate on peripheral blood cell counts in sublethally gamma-irradiated mice. ( Kozubík, A; Netíková, J; Pipalová, I; Pospísil, M, 1989) |
| "Pretreatment with indomethacin significantly decreased urine TxB2 and 6-keto-PGF1 alpha in both irradiated and nonirradiated animals." | 1.27 | Thromboxane and prostacyclin synthesis following whole body irradiation in rats. ( Kot, PA; Ramwell, PW; Rose, JC; Schneidkraut, MJ, 1984) |
| "Domperidone pretreatment prevented radiation-induced emesis in all of four dogs tested." | 1.27 | Radiation-induced emesis in the dog: effects of lesions and drugs. ( Briggs, DB; Carpenter, DO; Knox, AP; Strominger, NL, 1986) |
| "Indomethacin-treated animals showed no signs or only mild esophagitis posttreatment." | 1.26 | Radiation esophagitis in the opossum: radioprotection with indomethacin. ( Feldman, MS; Libshitz, HI; Mamel, JJ; Northway, MG; Osborne, BM; Szwarc, IA; West, JH, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (47.62) | 18.7374 |
| 1990's | 9 (42.86) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, J | 1 |
| Hacker, H | 1 |
| Schuschereba, ST | 1 |
| Zwick, H | 1 |
| Lund, DJ | 1 |
| Stuck, BE | 1 |
| Schneidkraut, MJ | 1 |
| Kot, PA | 1 |
| Ramwell, PW | 1 |
| Rose, JC | 1 |
| Woodward, DF | 1 |
| Raval, P | 1 |
| Pipkin, MA | 1 |
| Owen, DA | 1 |
| Bito, LZ | 1 |
| Klein, EM | 1 |
| Northway, MG | 1 |
| Libshitz, HI | 1 |
| Osborne, BM | 1 |
| Feldman, MS | 1 |
| Mamel, JJ | 1 |
| West, JH | 1 |
| Szwarc, IA | 1 |
| Floersheim, GL | 1 |
| Orfanos, SE | 1 |
| Chen, XL | 1 |
| Burch, SE | 1 |
| Ryan, JW | 1 |
| Chung, AY | 1 |
| Catravas, JD | 1 |
| Besa, PC | 1 |
| Hunter, NR | 1 |
| Milas, L | 2 |
| Andley, UP | 1 |
| Fritz, C | 1 |
| Morrison, AR | 1 |
| Becker, B | 1 |
| Trott, KR | 1 |
| Shirazi, A | 1 |
| Heasman, F | 1 |
| Riehl, T | 1 |
| Cohn, S | 1 |
| Tessner, T | 1 |
| Schloemann, S | 1 |
| Stenson, WF | 1 |
| Nishiguchi, I | 1 |
| Hunter, N | 1 |
| Murray, D | 1 |
| Fleck, R | 1 |
| Ito, H | 1 |
| Travis, E | 1 |
| Snyder, DS | 1 |
| Rose, PG | 1 |
| Halter, SA | 1 |
| Su, CM | 1 |
| Gross, NJ | 1 |
| Holloway, NO | 1 |
| Narine, KR | 1 |
| Tochner, Z | 1 |
| Barnes, M | 1 |
| Mitchell, JB | 1 |
| Orr, K | 1 |
| Glatstein, E | 1 |
| Russo, A | 1 |
| Pospísil, M | 1 |
| Netíková, J | 1 |
| Kozubík, A | 1 |
| Pipalová, I | 1 |
| Carpenter, DO | 2 |
| Briggs, DB | 2 |
| Strominger, NL | 2 |
| Delattre, JY | 1 |
| Rosenblum, MK | 1 |
| Thaler, HT | 1 |
| Mandell, L | 1 |
| Shapiro, WR | 1 |
| Posner, JB | 1 |
| Meyrick, B | 1 |
| Perkett, EA | 1 |
| Brigham, KL | 1 |
| Knox, AP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study of Spinal Radiosurgery[NCT00573872] | 43 participants (Actual) | Interventional | 2005-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
CTCAE version 3. Acute toxicity will be recorded if toxicity occurs early phase or within 3 months, and late toxicity would be any toxicity that follows those 3 months. (NCT00573872)
Timeframe: 2 years
| Intervention | events (Number) |
|---|---|
| Spinal Radiosurgery | 4 |
Lack of tumor growth by CT or MRI at last follow-up (NCT00573872)
Timeframe: 2 years
| Intervention | Participants (Count of Participants) |
|---|---|
| Spinal Radiosurgery | 21 |
"Physician's subjective report of palliative pain relief. The maximal benefit patient received (best response) is reported. Scale is pain described as worse, stable, better, or completely resolved. In the reporting better or completely resolved indicates response to treatment." (NCT00573872)
Timeframe: 2 years
| Intervention | Participants (Count of Participants) |
|---|---|
| Spinal Radiosurgery | 29 |
21 other studies available for indomethacin and Experimental Radiation Injuries
| Article | Year |
|---|---|
Steroidal and nonsteroidal antiinflammatory medications can improve photoreceptor survival after laser retinal photocoagulation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cell Survival; Coloring Agents; Fluore | 2007 |
Thromboxane and prostacyclin synthesis following whole body irradiation in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Indomethacin; Kidney; Male; Osmolar Concentration; Premedicat | 1984 |
Re-evaluation of the effect of non-steroidal anti-inflammatory agents on u.v.-induced cutaneous inflammation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Body Temperature; Dermatitis | 1981 |
The role of the arachidonic acid cascade in the species-specific X-ray-induced inflammation of the rabbit eye.
Topics: Animals; Arachidonic Acids; Cromolyn Sodium; Endophthalmitis; Eye; Female; Flurbiprofen; Imidazoles; | 1982 |
Radiation esophagitis in the opossum: radioprotection with indomethacin.
Topics: Animals; Cobalt Radioisotopes; Esophagitis; Esophagus; Gamma Rays; Indomethacin; Mucous Membrane; Op | 1980 |
Allopurinol, indomethacin and riboflavin enhance radiation lethality in mice.
Topics: Allopurinol; Animals; Cobalt Radioisotopes; Dose-Response Relationship, Drug; Female; Indomethacin; | 1994 |
Radiation-induced early pulmonary endothelial ectoenzyme dysfunction in vivo: effect of indomethacin.
Topics: Animals; Endothelium, Vascular; Hemodynamics; Indicator Dilution Techniques; Indomethacin; Lung; Mal | 1994 |
Improvement in radiotherapy for a murine sarcoma by indomethacin plus WR-2721.
Topics: Amifostine; Animals; Contracture; Drug Therapy, Combination; Indomethacin; Male; Mice; Mice, Inbred | 1993 |
The role of prostaglandins E2 and F2 alpha in ultraviolet radiation-induced cortical cataracts in vivo.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cataract; Ciliary Body; Conjunctiva; Cornea; Cyclooxygenase I | 1996 |
Modulation of accelerated repopulation in mouse skin during daily irradiation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Dermatitis; Epidermal Cells; Epider | 1999 |
Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism.
Topics: Animals; Blotting, Western; Body Temperature; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Cyc | 2000 |
Radiation protection against early and late effects of ionizing irradiation by the prostaglandin inhibitor indomethacin.
Topics: Amifostine; Animals; Contracture; Digestive System; Drug Therapy, Combination; Gamma Rays; Hair Foll | 1992 |
Effect of topical indomethacin on UVR-induced redness and prostaglandin E levels in sunburned guinea pig skin.
Topics: Administration, Topical; Animals; Female; Guinea Pigs; Indomethacin; Prostaglandins E; Radiation Inj | 1976 |
The effect of indomethacin on acute radiation induced gastrointestinal injury: a morphologic study.
Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enteritis; I | 1992 |
Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diethylcarbamazine; Ibupro | 1991 |
Protection by indomethacin against acute radiation esophagitis.
Topics: Acute Disease; Animals; Body Weight; Dose-Response Relationship, Radiation; Esophagitis; Esophagus; | 1990 |
Effect of indomethacin, diclofenac sodium and sodium salicylate on peripheral blood cell counts in sublethally gamma-irradiated mice.
Topics: Animals; Blood Cell Count; Diclofenac; Dose-Response Relationship, Drug; Hematopoiesis; Indomethacin | 1989 |
Mechanisms of radiation-induced emesis in the dog.
Topics: Animals; Dogs; Domperidone; Electrophysiology; Female; Indomethacin; Male; Radiation Injuries, Exper | 1988 |
A model of radiation myelopathy in the rat. Pathology, regional capillary permeability changes and treatment with dexamethasone.
Topics: Angiography; Animals; Autoradiography; Capillary Permeability; Dexamethasone; Indomethacin; Male; Pa | 1988 |
Inflammation and models of chronic pulmonary hypertension.
Topics: Animals; Endotoxins; Escherichia coli; Hypertension, Pulmonary; Indomethacin; Lung; Pneumonia; Radia | 1987 |
Radiation-induced emesis in the dog: effects of lesions and drugs.
Topics: Animals; Apomorphine; Cerebral Ventricles; Dogs; Domperidone; Indomethacin; Neurons; Prostaglandins; | 1986 |