indomethacin has been researched along with Esophagitis in 9 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Esophagitis: INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effect of the prostaglandin synthetase inhibitor indomethacin on radiation induced esophagitis, pneumonitis, and tumor response was evaluated in the C3H mouse." | 7.68 | Protection by indomethacin against acute radiation esophagitis. ( Barnes, M; Glatstein, E; Mitchell, JB; Orr, K; Russo, A; Tochner, Z, 1990) |
| "Indomethacin-treated animals showed no signs or only mild esophagitis posttreatment." | 5.26 | Radiation esophagitis in the opossum: radioprotection with indomethacin. ( Feldman, MS; Libshitz, HI; Mamel, JJ; Northway, MG; Osborne, BM; Szwarc, IA; West, JH, 1980) |
| "The effect of ketoprofen, a nonsteroidal anti-inflammatory drug, was tested on the upper gastrointestinal tract (UGIT) in patients with osteoarthritis." | 5.06 | A prospective endoscopic study of the effect of Orudis and Oruvail on the upper gastrointestinal tract, in patients with osteoarthritis. ( Collins, AJ; Davies, J; Dixon, AS, 1988) |
| "In this rat model of gastrointestinal reflux, indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma." | 3.78 | Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ( Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2012) |
| " The effect of the prostaglandin synthetase inhibitor indomethacin on radiation induced esophagitis, pneumonitis, and tumor response was evaluated in the C3H mouse." | 3.68 | Protection by indomethacin against acute radiation esophagitis. ( Barnes, M; Glatstein, E; Mitchell, JB; Orr, K; Russo, A; Tochner, Z, 1990) |
| "Indomethacin-treated animals showed no signs or only mild esophagitis posttreatment." | 1.26 | Radiation esophagitis in the opossum: radioprotection with indomethacin. ( Feldman, MS; Libshitz, HI; Mamel, JJ; Northway, MG; Osborne, BM; Szwarc, IA; West, JH, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Esquivias, P | 1 |
| Morandeira, A | 1 |
| Escartín, A | 2 |
| Cebrián, C | 1 |
| Santander, S | 1 |
| Esteva, F | 2 |
| García-González, MA | 1 |
| Ortego, J | 2 |
| Lanas, A | 2 |
| Piazuelo, E | 1 |
| Jiménez, P | 1 |
| Ferrández, A | 1 |
| Arenas, J | 1 |
| Yamato, M | 1 |
| Nagahama, K | 1 |
| Kotani, T | 1 |
| Kato, S | 1 |
| Takeuchi, K | 1 |
| Northway, MG | 1 |
| Libshitz, HI | 1 |
| Osborne, BM | 1 |
| Feldman, MS | 1 |
| Mamel, JJ | 1 |
| West, JH | 1 |
| Szwarc, IA | 1 |
| Swift, GL | 1 |
| Arnold, J | 1 |
| Williams, GT | 1 |
| Williams, BD | 1 |
| Rhodes, J | 1 |
| Khan, F | 1 |
| Tochner, Z | 1 |
| Barnes, M | 1 |
| Mitchell, JB | 1 |
| Orr, K | 1 |
| Glatstein, E | 1 |
| Russo, A | 1 |
| Stein, BE | 1 |
| Schwartzman, ML | 1 |
| Carroll, MA | 1 |
| Stahl, RE | 1 |
| Rosenthal, WS | 1 |
| Collins, AJ | 1 |
| Davies, J | 1 |
| Dixon, AS | 1 |
| Nicolopoulos, N | 1 |
| Mantidis, A | 1 |
| Stathopoulos, E | 1 |
| Papaodysseas, S | 1 |
| Kouvaris, J | 1 |
| Varveris, H | 1 |
| Papavasiliou, C | 1 |
3 trials available for indomethacin and Esophagitis
| Article | Year |
|---|---|
A comparison of upper gastrointestinal mucosal damage by standard and delayed-release indomethacin.
Topics: Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Double-Blind Method; Duodenal Ulcer; Du | 1992 |
A prospective endoscopic study of the effect of Orudis and Oruvail on the upper gastrointestinal tract, in patients with osteoarthritis.
Topics: Administration, Oral; Delayed-Action Preparations; Double-Blind Method; Duodenitis; Endoscopy; Esoph | 1988 |
Prophylactic administration of indomethacin for irradiation esophagitis.
Topics: Clinical Trials as Topic; Double-Blind Method; Esophagitis; Female; Humans; Indomethacin; Lung Neopl | 1985 |
6 other studies available for indomethacin and Esophagitis
| Article | Year |
|---|---|
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic | 2012 |
Selective COX-2 inhibition is associated with decreased mucosal damage induced by acid and pepsin in rabbit esophagitis.
Topics: Acids; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhi | 2003 |
Biphasic effect of prostaglandin E2 in a rat model of esophagitis mediated by EP1 receptors: relation to pepsin secretion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Cytoprotection; Dinopro | 2005 |
Radiation esophagitis in the opossum: radioprotection with indomethacin.
Topics: Animals; Cobalt Radioisotopes; Esophagitis; Esophagus; Gamma Rays; Indomethacin; Mucous Membrane; Op | 1980 |
Protection by indomethacin against acute radiation esophagitis.
Topics: Acute Disease; Animals; Body Weight; Dose-Response Relationship, Radiation; Esophagitis; Esophagus; | 1990 |
Role of arachidonic acid metabolites in acid-pepsin injury to rabbit esophagus.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents, Non | 1989 |