indomethacin has been researched along with Esophageal Neoplasms in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this rat model of gastrointestinal reflux, indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma." | 3.78 | Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ( Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2012) |
| "Indomethacin and parecoxib inhibit the growth of human esophageal adenocarcinoma xenografts in nude mice, which suggests a potential role for NSAIDs or selective COX-2 inhibitors for EAC chemotherapy." | 1.38 | Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice. ( Cebrián, C; Conde, B; Esquivias, P; Esteva, F; Jiménez, P; Lanas, A; Ortego, J; Piazuelo, E; Santander, S, 2012) |
| "Esophageal and tongue cancers have both been associated with dietary zinc deficiency (ZD), and cyclooxygenase (COX-2) is often overexpressed in these cancers." | 1.33 | Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. ( Farber, JL; Fong, LY; Jiang, Y; Zhang, L, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, F | 1 |
| Wu, Q | 1 |
| Han, W | 1 |
| Laster, K | 1 |
| Hu, Y | 1 |
| Ma, F | 1 |
| Chen, H | 1 |
| Tian, X | 1 |
| Qiao, Y | 1 |
| Liu, H | 1 |
| Kim, DJ | 1 |
| Dong, Z | 1 |
| Liu, K | 1 |
| Qin, S | 1 |
| Xu, C | 1 |
| Li, S | 1 |
| Yang, C | 1 |
| Sun, X | 1 |
| Wang, X | 1 |
| Tang, SC | 1 |
| Ren, H | 1 |
| Yu, L | 1 |
| Wu, WK | 1 |
| Li, ZJ | 1 |
| Liu, QC | 1 |
| Li, HT | 1 |
| Wu, YC | 1 |
| Cho, CH | 1 |
| Santander, S | 2 |
| Cebrián, C | 2 |
| Esquivias, P | 2 |
| Conde, B | 1 |
| Esteva, F | 2 |
| Jiménez, P | 1 |
| Ortego, J | 2 |
| Lanas, A | 2 |
| Piazuelo, E | 2 |
| Morandeira, A | 1 |
| Escartín, A | 1 |
| García-González, MA | 1 |
| Fong, LY | 1 |
| Zhang, L | 1 |
| Jiang, Y | 1 |
| Farber, JL | 1 |
| Rubio, CA | 2 |
| Morgan, GP | 1 |
| Williams, JG | 1 |
| Sato, K | 1 |
| Fujii, Y | 1 |
| Kasono, K | 1 |
| Tsushima, T | 1 |
| Shizume, K | 1 |
| Kiczka, W | 1 |
| Szkaradkiewicz, A | 1 |
11 other studies available for indomethacin and Esophageal Neoplasms
| Article | Year |
|---|---|
Targeting integrin αvβ3 with indomethacin inhibits patient-derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cell Surviva | 2021 |
Indomethacin induces apoptosis in the EC109 esophageal cancer cell line by releasing second mitochondria-derived activator of caspase and activating caspase-3.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Cell L | 2015 |
Enhancement of doxorubicin cytotoxicity on human esophageal squamous cell carcinoma cells by indomethacin and 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC236) via inhibiting P-glycoprotein activity.
Topics: Adenosine Triphosphatases; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antineoplastic; ATP | 2009 |
Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice.
Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooxy | 2012 |
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic | 2012 |
Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Ce | 2005 |
Antitumoral activity of indomethacin on experimental esophageal tumors.
Topics: Animals; Diethylnitrosamine; Drug Administration Schedule; Esophageal Neoplasms; Indomethacin; Male; | 1984 |
Tumouricidal effect of indomethacin in the esophagus.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Esophageal Neoplasms; Humans; Indomethac | 1993 |
Production of interleukin-1 alpha and a parathyroid hormone-like factor by a squamous cell carcinoma of the esophagus (EC-GI) derived from a patient with hypercalcemia.
Topics: Aged; Animals; Bone Resorption; Carcinoma, Squamous Cell; Chromatography; DNA; Esophageal Neoplasms; | 1988 |
Further studies on the therapeutic effect of indomethacin on esophageal tumors.
Topics: Animals; Diethylnitrosamine; Esophageal Neoplasms; Female; Indomethacin; Mice; Mice, Inbred C57BL | 1986 |
Suppression of monocyte mediated anti U562 cytotoxicity by soluble factors in the serum of cancer patients and in the supernatant of K562 cell culture.
Topics: Adult; Aged; Cells, Cultured; Cytotoxicity, Immunologic; Esophageal Neoplasms; Gastrointestinal Neop | 1986 |