Page last updated: 2024-10-29

indomethacin and Esophageal Neoplasms

indomethacin has been researched along with Esophageal Neoplasms in 11 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.

Research Excerpts

ExcerptRelevanceReference
"In this rat model of gastrointestinal reflux, indomethacin was associated with a decrease in the severity of esophagitis and reduced development of esophageal intestinal metaplasia and adenocarcinoma."3.78Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ( Cebrián, C; Escartín, A; Esquivias, P; Esteva, F; García-González, MA; Lanas, A; Morandeira, A; Ortego, J; Piazuelo, E; Santander, S, 2012)
"Indomethacin and parecoxib inhibit the growth of human esophageal adenocarcinoma xenografts in nude mice, which suggests a potential role for NSAIDs or selective COX-2 inhibitors for EAC chemotherapy."1.38Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice. ( Cebrián, C; Conde, B; Esquivias, P; Esteva, F; Jiménez, P; Lanas, A; Ortego, J; Piazuelo, E; Santander, S, 2012)
"Esophageal and tongue cancers have both been associated with dietary zinc deficiency (ZD), and cyclooxygenase (COX-2) is often overexpressed in these cancers."1.33Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. ( Farber, JL; Fong, LY; Jiang, Y; Zhang, L, 2005)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19904 (36.36)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's3 (27.27)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Liu, F1
Wu, Q1
Han, W1
Laster, K1
Hu, Y1
Ma, F1
Chen, H1
Tian, X1
Qiao, Y1
Liu, H1
Kim, DJ1
Dong, Z1
Liu, K1
Qin, S1
Xu, C1
Li, S1
Yang, C1
Sun, X1
Wang, X1
Tang, SC1
Ren, H1
Yu, L1
Wu, WK1
Li, ZJ1
Liu, QC1
Li, HT1
Wu, YC1
Cho, CH1
Santander, S2
Cebrián, C2
Esquivias, P2
Conde, B1
Esteva, F2
Jiménez, P1
Ortego, J2
Lanas, A2
Piazuelo, E2
Morandeira, A1
Escartín, A1
García-González, MA1
Fong, LY1
Zhang, L1
Jiang, Y1
Farber, JL1
Rubio, CA2
Morgan, GP1
Williams, JG1
Sato, K1
Fujii, Y1
Kasono, K1
Tsushima, T1
Shizume, K1
Kiczka, W1
Szkaradkiewicz, A1

Other Studies

11 other studies available for indomethacin and Esophageal Neoplasms

ArticleYear
Targeting integrin αvβ3 with indomethacin inhibits patient-derived xenograft tumour growth and recurrence in oesophageal squamous cell carcinoma.
    Clinical and translational medicine, 2021, Volume: 11, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Cell Surviva

2021
Indomethacin induces apoptosis in the EC109 esophageal cancer cell line by releasing second mitochondria-derived activator of caspase and activating caspase-3.
    Molecular medicine reports, 2015, Volume: 11, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Cell L

2015
Enhancement of doxorubicin cytotoxicity on human esophageal squamous cell carcinoma cells by indomethacin and 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC236) via inhibiting P-glycoprotein activity.
    Molecular pharmacology, 2009, Volume: 75, Issue:6

    Topics: Adenosine Triphosphatases; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antineoplastic; ATP

2009
Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice.
    International journal of oncology, 2012, Volume: 40, Issue:2

    Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooxy

2012
Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats.
    World journal of gastroenterology, 2012, Sep-21, Volume: 18, Issue:35

    Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Barrett Esophagus; Cell Transformation, Neoplastic

2012
Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats.
    Journal of the National Cancer Institute, 2005, Jan-05, Volume: 97, Issue:1

    Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Ce

2005
Antitumoral activity of indomethacin on experimental esophageal tumors.
    Journal of the National Cancer Institute, 1984, Volume: 72, Issue:3

    Topics: Animals; Diethylnitrosamine; Drug Administration Schedule; Esophageal Neoplasms; Indomethacin; Male;

1984
Tumouricidal effect of indomethacin in the esophagus.
    Postgraduate medical journal, 1993, Volume: 69, Issue:818

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Esophageal Neoplasms; Humans; Indomethac

1993
Production of interleukin-1 alpha and a parathyroid hormone-like factor by a squamous cell carcinoma of the esophagus (EC-GI) derived from a patient with hypercalcemia.
    The Journal of clinical endocrinology and metabolism, 1988, Volume: 67, Issue:3

    Topics: Aged; Animals; Bone Resorption; Carcinoma, Squamous Cell; Chromatography; DNA; Esophageal Neoplasms;

1988
Further studies on the therapeutic effect of indomethacin on esophageal tumors.
    Cancer, 1986, Sep-01, Volume: 58, Issue:5

    Topics: Animals; Diethylnitrosamine; Esophageal Neoplasms; Female; Indomethacin; Mice; Mice, Inbred C57BL

1986
Suppression of monocyte mediated anti U562 cytotoxicity by soluble factors in the serum of cancer patients and in the supernatant of K562 cell culture.
    Immunology letters, 1986, Volume: 13, Issue:3

    Topics: Adult; Aged; Cells, Cultured; Cytotoxicity, Immunologic; Esophageal Neoplasms; Gastrointestinal Neop

1986