indomethacin has been researched along with Epilepsy in 9 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the case of a 17-year-old boy presenting with a history of recurrent episodes of isolated visual aura later followed infrequently by indomethacin-responsive headache attacks resembling paroxysmal hemicrania." | 3.75 | Paroxysmal hemicrania with visual aura in a 17-year-old boy. ( Seidel, S; Wöber, C, 2009) |
| "As parameters of epileptic seizure, seizure threshold (number of toss-ups to induce convulsion), duration of actual convulsion and duration of post actual convulsive period (period from the offset of convulsion to full recovery) were evaluated." | 1.33 | Cyclooxygenase system contributes to the maintenance of post convulsive period of epileptic phenomena in the genetically epileptic El mice. ( Okada, K; Tsuji, S; Yamashita, U, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Fantini, J | 1 |
| Koscica, N | 1 |
| Zorzon, M | 1 |
| Belluzzo, M | 1 |
| Granato, A | 1 |
| Tu, YF | 1 |
| Wang, LW | 1 |
| Wang, ST | 1 |
| Yeh, TF | 1 |
| Huang, CC | 1 |
| Seidel, S | 1 |
| Wöber, C | 1 |
| Tanaka, S | 1 |
| Nakamura, T | 1 |
| Sumitani, K | 1 |
| Takahashi, F | 1 |
| Konishi, R | 1 |
| Itano, T | 1 |
| Miyamoto, O | 1 |
| Kovács, Z | 1 |
| Czurkó, A | 1 |
| Kékesi, KA | 1 |
| Juhász, G | 1 |
| Okada, K | 1 |
| Yamashita, U | 1 |
| Tsuji, S | 1 |
| Siesjö, BK | 1 |
| Nilsson, B | 1 |
| VanDoren, MJ | 1 |
| Matthews, DB | 1 |
| Janis, GC | 1 |
| Grobin, AC | 1 |
| Devaud, LL | 1 |
| Morrow, AL | 1 |
2 reviews available for indomethacin and Epilepsy
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Prostaglandins and the cerebral circulation.
Topics: Animals; Brain; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Dose-Response Relationship, | 1982 |
7 other studies available for indomethacin and Epilepsy
| Article | Year |
|---|---|
Hemicrania continua with visual aura successfully treated with a combination of indomethacin and topiramate.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Therapy, Combination; Epilepsy | 2015 |
Postnatal Steroids and Febrile Seizure Susceptibility in Preterm Children.
Topics: Adrenal Cortex Hormones; Child, Preschool; Disease Susceptibility; Epilepsy; Female; Gestational Age | 2016 |
Paroxysmal hemicrania with visual aura in a 17-year-old boy.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Epilepsy; Humans; Indomethacin; Male; Paroxysma | 2009 |
Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model.
Topics: Amygdala; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Epilepsy; Hippocam | 2009 |
Intracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyt | 2011 |
Cyclooxygenase system contributes to the maintenance of post convulsive period of epileptic phenomena in the genetically epileptic El mice.
Topics: Animals; Cerebral Cortex; Cyclooxygenase 2; Disease Models, Animal; Epilepsy; Indomethacin; Injectio | 2006 |
Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol.
Topics: Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Central Nervous System Depressants; Cerebra | 2000 |