Page last updated: 2024-10-29

indomethacin and Embryopathies

indomethacin has been researched along with Embryopathies in 44 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"A case is reported in which exposure to cocaine and indomethacin was associated with development of fetal anuria, anasarca, and neonatal gastrointestinal hemorrhage."7.68Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding. ( Angel, JL; Carlan, SJ; Harris, M; O'Brien, WF; Stromquist, C, 1991)
"(2) Multiple analyses showed that patent ductus arteriosus(PDA) (odds ratio[OR] = 5."5.91Patent ductus arterious and increased conjugated bilirubin in the second week after birth are independent risk factors for necrotizing enterocolitis in preterm infants: an observational study. ( Cui, S; Han, X, 2023)
" D-Penicillamine may be teratogenic thus it should not be commenced during pregnancy and if a patient becomes pregnant whilst receiving the drug, it should be slowly withdrawn or the dosage reduced."4.77Antirheumatic medication in pregnancy. ( Brooks, PM; Needs, CJ, 1985)
"To test the hypothesis that intrauterine inflammation increases prostaglandin production and may be a risk factor for persistent ductus arteriosus after therapy with indomethacin, a nonselective cyclooxygenase inhibitor."3.76Intrauterine inflammation as a risk factor for persistent ductus arteriosus patency after cyclooxygenase inhibition in extremely low birth weight infants. ( Choi, CW; Choi, JH; Kim, BI; Kim, EK; Kim, ES; Kim, HS; Moon, KC; Park, JS, 2010)
"A case is reported in which exposure to cocaine and indomethacin was associated with development of fetal anuria, anasarca, and neonatal gastrointestinal hemorrhage."3.68Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding. ( Angel, JL; Carlan, SJ; Harris, M; O'Brien, WF; Stromquist, C, 1991)
"Indomethacin was given for the treatment of preterm labor in a twin pregnancy at a dosage of 200 mg/day for 7 days beginning at 34 weeks and 5 days' gestation."3.68Indomethacin for preterm labor: fetal toxicity in a dizygotic twin gestation. ( Ayres, NA; Hallak, M; Moise, KJ; Reiter, AA, 1991)
" During treatment with the basic drugs: gold, D-penicillamine and chloroquine, pregnancy should be avoided."3.65[Problems of rheumatic therapy in pregnancy (author's transl)]. ( Bischof, P, 1976)
"Forty patients with intact membranes in preterm labor at 23 to 34 weeks' gestation were randomized to receive either intravenous ritodrine or oral indomethacin as the first-line tocolytic agent."2.67Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor. ( Besinger, RE; Johnson, TR; Keyes, WG; Niebyl, JR, 1991)
"In all six cases, severe hydramnios occurred during pregnancy between the 26th and 28th week after the last menstrual period."2.38[Antenatal form of Bartter's syndrome]. ( Broyer, M; Burguet, A; Dechaux, M; Deschenes, G; Garabedian, M; Guyot, C; Hubert, P; Loirat, C, 1993)
"(2) Multiple analyses showed that patent ductus arteriosus(PDA) (odds ratio[OR] = 5."1.91Patent ductus arterious and increased conjugated bilirubin in the second week after birth are independent risk factors for necrotizing enterocolitis in preterm infants: an observational study. ( Cui, S; Han, X, 2023)
"Prenatally diagnosed Ebstein's anomaly with tricuspid valve dysplasia (EA/TVD) is a rare and high-risk congenital heart malformation with limited effective treatments."1.72Treatment of Severe Fetal Ebstein's Anomaly with Prenatal Nonsteroidal Anti-Inflammatory Therapy. ( Kraus, E; Lannaman, K; Powel, JE; Reddy, C, 2022)
"The treatment with Indomethacin in the antenatal period can prevent severe nephrocalcinosis."1.36Antenatal Bartter syndrome: analysis of two cases with placental findings. ( Aksoy, F; Cetin, A; Dane, B; Dane, C; Yayla, M, 2010)
"Persistent patent ductus arteriosus was more common in those infants delivered within 48 hours of maternal indomethacin exposure (40% versus 20% (p<0."1.30Antenatal indomethacin--adverse fetal effects confirmed. ( Baxendale, H; Harding, J; McCowan, L; McLeay, E; O'Donnell, C; Souter, D, 1998)
"Trivial tricuspid valve regurgitation was detected at a mean of 26."1.29Fetal echocardiography during indomethacin treatment. ( Huhta, JC; Respondek, M; Weil, SR, 1995)
"Isolated intestinal perforation has been described in premature neonates who were treated with indomethacin for patent ductus arteriosus."1.29Isolated small bowel perforation following intrauterine treatment with indomethacin. ( Bidiwala, KS; Delpino, ML; Fejgin, MD, 1994)
"When indomethacin was given, arterial blood gases in both groups showed a mild increase in carbon dioxide tension and similar placental blood flows (about 30% of baseline) after bypass."1.29Exclusion of the placenta during fetal cardiac bypass augments systemic flow and provides important information about the mechanism of placental injury. ( Fenton, KN; Hanley, FL; Heinemann, MK, 1993)
"I."1.28[The neonatal form of Bartter's syndrome: current findings in etiology and physiopathology]. ( Proesmans, WC, 1992)
"Indomethacin is a potent agent in the treatment of premature labor, but its use has been limited because of concern about its constrictive effects on the fetal ductus arteriosus."1.27Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus. ( Cano, L; Huhta, JC; Kirshon, B; Moise, KJ; Ou, CN; Sharif, DS; Wasserstrum, N, 1988)
"Indomethacin has been most effective but not free of significant complications."1.26Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem. ( Altmiller, DH; Altshuler, G; Krous, HF; Sharpe, GL, 1979)
"Indomethacin was present in fetal blood, and maternal plasma prostaglandin levels were suppressed."1.26Constriction of the fetal ductus arteriosus after administration of indomethacin to the pregnant ewe. ( Campbell, W; Garriott, J; Levin, DL; Mills, LJ; Parkey, M, 1979)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199010 (22.73)18.7374
1990's23 (52.27)18.2507
2000's6 (13.64)29.6817
2010's3 (6.82)24.3611
2020's2 (4.55)2.80

Authors

AuthorsStudies
Powel, JE1
Kraus, E1
Reddy, C1
Lannaman, K1
Han, X1
Cui, S1
Dane, B1
Dane, C1
Aksoy, F1
Cetin, A1
Yayla, M1
Kim, ES1
Kim, EK1
Choi, CW1
Kim, HS1
Kim, BI1
Choi, JH1
Park, JS1
Moon, KC1
Grigsby, PL1
Novy, MJ1
Sadowsky, DW1
Morgan, TK1
Long, M1
Acosta, E1
Duffy, LB1
Waites, KB1
Amsalem, H1
Valsky, DV1
Yagel, S1
Celnikier, DH1
Anteby, EY1
Kajino, H1
Taniguchi, T1
Fujieda, K1
Ushikubi, F1
Muramatsu, I1
Garza, J1
Clayton, N1
Kaviani, A1
Maher, TJ1
Fauza, D1
Respondek, M1
Weil, SR1
Huhta, JC3
Fejgin, MD1
Delpino, ML1
Bidiwala, KS1
Sabik, JF1
Heinemann, MK2
Assad, RS1
Hanley, FL2
Van den Veyver, IB1
Moise, KJ6
Eronen, M1
Fenton, KN1
Deschenes, G1
Burguet, A1
Guyot, C1
Hubert, P1
Garabedian, M1
Dechaux, M1
Loirat, C1
Broyer, M1
Murray, HG1
Stone, PR1
Strand, L1
Flower, J1
Takahashi, Y1
Harada, K2
Ishida, A1
Tanaka, T1
Tsuda, A1
Takada, G1
Archer, N1
Rice, MJ1
McDonald, RW1
Shiota, T1
Ishii, M1
Reller, MD1
Sahn, DJ1
Souter, D1
Harding, J1
McCowan, L1
O'Donnell, C1
McLeay, E1
Baxendale, H1
Humphrey, M1
King, G1
Tong, H1
Wood, CE1
Narchi, H1
Santos, M1
Kulaylat, N1
Paek, BW1
Jennings, RW1
Harrison, MR1
Filly, RA1
Tacy, TA1
Farmer, DL1
Albanese, CT1
Kumar, R1
Sharma, YP1
Gupta, I1
Altshuler, G1
Krous, HF1
Altmiller, DH1
Sharpe, GL1
Levin, DL1
Mills, LJ1
Parkey, M1
Garriott, J1
Campbell, W1
Bischof, P1
Bavoux, F1
Proesmans, WC1
Díaz-Calderon, O1
Velazco-Olivares, M1
Danglot-Banck, C1
Gómez-Gomez, M1
Covarrubias-Villegas, R1
Carlan, SJ1
Stromquist, C1
Angel, JL1
Harris, M1
O'Brien, WF1
Hallak, M1
Reiter, AA1
Ayres, NA1
Besinger, RE1
Niebyl, JR1
Keyes, WG1
Johnson, TR1
Momma, K1
Takao, A1
Sharif, DS2
Ou, CN1
Kirshon, B1
Wasserstrum, N2
Cano, L1
Fisher, DJ1
Martin, C1
Needs, CJ1
Brooks, PM1
Persaud, TV2
Moore, KL1
O'Grady, JP1
Caldwell, BV1
Auletta, FJ1
Speroff, L1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes. A Randomized Prospective, Open Trial[NCT02819570]Phase 4400 participants (Anticipated)Interventional2015-11-30Recruiting
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680]11,976 participants (Actual)Interventional2016-03-23Completed
Vaginal Indomethacin Versus Oral Nifedipine for Preterm Labor; a Randomized Controlled Trial[NCT04404686]Phase 2/Phase 3300 participants (Anticipated)Interventional2020-10-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

- Early preterm delivery (<34 weeks) (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm189
Placebo Arm230

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

- Birth weight <2500g (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm1078
Placebo Arm1153

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

- Birth weight <1500g (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm78
Placebo Arm101

Fetal Outcome 4 - Incidence of Fetal Loss

- Incidence of Fetal Loss (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm303
Placebo Arm353

Fetal Outcome 5 - Incidence of Spontaneous Abortion

- Incidence of Spontaneous Abortion (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm134
Placebo Arm152

Fetal Outcome 6 - Incidence of All Stillbirth

- Incidence of All stillbirth (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm141
Placebo Arm166

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm42
Placebo Arm30

Incidence of Hypertensive Disorders of Pregnancy

- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)

InterventionParticipants (Count of Participants)
Intervention Arm352
Placebo Arm325

Incidence of Perinatal Mortality

- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm264
Placebo Arm309

Incidence of Preterm Birth

The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery

InterventionParticipants (Count of Participants)
Intervention Arm668
Placebo Arm754

Incidence of Small for Gestational Age (SGA)

- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm1506
Placebo Arm1564

Maternal Outcome 1 - Incidence of Vaginal Bleeding

- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm214
Placebo Arm246

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm26
Placebo Arm25

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm54
Placebo Arm43

Maternal Outcome 4 - Incidence of Maternal Mortality

- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm9
Placebo Arm12

Maternal Outcome 5 - Incidence of Late Abortion

- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm23
Placebo Arm30

Maternal Outcome 6 - Change in Maternal Hemoglobin

Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.

InterventionParticipants (Count of Participants)
Intervention Arm290
Placebo Arm333

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

InterventionParticipants (Count of Participants)
Intervention Arm8
Placebo Arm21

Reviews

5 reviews available for indomethacin and Embryopathies

ArticleYear
Prostaglandin synthetase inhibitors in pregnancy.
    Obstetrical & gynecological survey, 1993, Volume: 48, Issue:7

    Topics: Animals; Contraindications; Cyclooxygenase Inhibitors; Female; Fetal Diseases; Forecasting; Humans;

1993
Polyhydramnios: problems and treatment.
    Seminars in perinatology, 1993, Volume: 17, Issue:3

    Topics: Amniocentesis; Female; Fetal Diseases; Humans; Incidence; Indomethacin; Polyhydramnios; Pregnancy; T

1993
[Antenatal form of Bartter's syndrome].
    Annales de pediatrie, 1993, Volume: 40, Issue:2

    Topics: Aldosterone; Bartter Syndrome; Calcium; Female; Fetal Diseases; Gestational Age; Humans; Indomethaci

1993
[Fetal toxicity of non-steroidal anti-inflammatory agents].
    Presse medicale (Paris, France : 1983), 1992, Nov-28, Volume: 21, Issue:40

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Fetal Diseases; Heart Failure; Humans; Indomethacin

1992
Antirheumatic medication in pregnancy.
    British journal of rheumatology, 1985, Volume: 24, Issue:3

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Antineoplas

1985

Trials

2 trials available for indomethacin and Embryopathies

ArticleYear
The hemodynamic effects of antenatal indomethacin and a beta-sympathomimetic agent on the fetus and the newborn: a randomized study.
    Pediatric research, 1993, Volume: 33, Issue:6

    Topics: Adult; Blood Flow Velocity; Ductus Arteriosus, Patent; Female; Fetal Diseases; Fetus; Gestational Ag

1993
Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor.
    American journal of obstetrics and gynecology, 1991, Volume: 164, Issue:4

    Topics: Amniotic Fluid; Diseases in Twins; Female; Fetal Diseases; Humans; Hypertension, Pulmonary; Indometh

1991

Other Studies

37 other studies available for indomethacin and Embryopathies

ArticleYear
Treatment of Severe Fetal Ebstein's Anomaly with Prenatal Nonsteroidal Anti-Inflammatory Therapy.
    Fetal diagnosis and therapy, 2022, Volume: 49, Issue:5-6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ebstein Anomaly; Female; Fetal Diseases; Heart Defects, Con

2022
Patent ductus arterious and increased conjugated bilirubin in the second week after birth are independent risk factors for necrotizing enterocolitis in preterm infants: an observational study.
    BMC pediatrics, 2023, 07-13, Volume: 23, Issue:1

    Topics: Bilirubin; Child; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Female; Fetal Diseases; Hum

2023
Antenatal Bartter syndrome: analysis of two cases with placental findings.
    Fetal and pediatric pathology, 2010, Volume: 29, Issue:3

    Topics: Adult; Amniocentesis; Amniotic Fluid; Anti-Inflammatory Agents, Non-Steroidal; Arteriosclerosis; Bar

2010
Intrauterine inflammation as a risk factor for persistent ductus arteriosus patency after cyclooxygenase inhibition in extremely low birth weight infants.
    The Journal of pediatrics, 2010, Volume: 157, Issue:5

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Fetal Diseases; Humans; Indomethacin;

2010
Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model.
    American journal of obstetrics and gynecology, 2012, Volume: 207, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A

2012
Effect of indomethacin on amniotic fluid prostaglandin and aldosterone levels in a fetus with Bartter syndrome.
    Prenatal diagnosis, 2003, Volume: 23, Issue:5

    Topics: Adult; Aldosterone; Amniotic Fluid; Bartter Syndrome; Cesarean Section; Female; Fetal Diseases; Huma

2003
An EP4 receptor agonist prevents indomethacin-induced closure of rat ductus arteriosus in vivo.
    Pediatric research, 2004, Volume: 56, Issue:4

    Topics: Animals; Cardiovascular Agents; Drug Interactions; Ductus Arteriosus; Female; Fetal Diseases; Heptan

2004
In situ inhibition of uterine activity by indomethacin: possible relevance to preterm labor prevention after fetal surgery.
    Journal of pediatric surgery, 2004, Volume: 39, Issue:8

    Topics: Animals; Depression, Chemical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Femal

2004
Fetal echocardiography during indomethacin treatment.
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 1995, Volume: 5, Issue:2

    Topics: Arterial Occlusive Diseases; Blood Flow Velocity; Constriction, Pathologic; Ductus Arteriosus; Echoc

1995
Isolated small bowel perforation following intrauterine treatment with indomethacin.
    American journal of perinatology, 1994, Volume: 11, Issue:4

    Topics: Adult; Female; Fetal Diseases; Humans; Ileal Diseases; Indomethacin; Infant, Newborn; Intestinal Per

1994
High-dose steroids prevent placental dysfunction after fetal cardiac bypass.
    The Journal of thoracic and cardiovascular surgery, 1994, Volume: 107, Issue:1

    Topics: Animals; Bicarbonates; Blood Flow Velocity; Carbon Dioxide; Cardiac Output; Cardiopulmonary Bypass;

1994
Exclusion of the placenta during fetal cardiac bypass augments systemic flow and provides important information about the mechanism of placental injury.
    The Journal of thoracic and cardiovascular surgery, 1993, Volume: 105, Issue:3

    Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Cardiac Output; Extracorporeal Circulation; Female; Fet

1993
Fetal pleural effusion following maternal indomethacin therapy.
    British journal of obstetrics and gynaecology, 1993, Volume: 100, Issue:3

    Topics: Adult; Cesarean Section; Diseases in Twins; Female; Fetal Diseases; Humans; Indomethacin; Pleural Ef

1993
Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin use.
    American journal of obstetrics and gynecology, 1993, Volume: 168, Issue:5

    Topics: Constriction, Pathologic; Ductus Arteriosus; Echocardiography; Female; Fetal Diseases; Gestational A

1993
Doppler echocardiographic findings of indomethacin-induced occlusion of the fetal ductus arteriosus.
    American journal of perinatology, 1996, Volume: 13, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cesarean Section; Cyclooxygenase Inhibitors; Dilatat

1996
Drug induced closure of patent ductus arteriosus.
    Heart (British Cardiac Society), 1996, Volume: 76, Issue:5

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Fetal Diseases; Humans; Indomethacin;

1996
Doppler echocardiographic evaluation of ventricular diastolic filling in fetuses with ductal constriction.
    The American journal of cardiology, 1997, Feb-15, Volume: 79, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Constriction, Pathologic; Ductus Arteriosus; Echocardiograp

1997
Antenatal indomethacin--adverse fetal effects confirmed.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1998, Volume: 38, Issue:1

    Topics: Cerebral Hemorrhage; Ductus Arteriosus, Patent; Female; Fetal Diseases; Humans; Indomethacin; Infant

1998
Re: The debate regarding the risks of tocolytic agents.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1998, Volume: 38, Issue:3

    Topics: Cerebral Hemorrhage; Ductus Arteriosus, Patent; Female; Fetal Diseases; Humans; Indomethacin; Kidney

1998
Premature closure of the fetal ductus arteriosus after maternal use of non-steroidal anti-inflammatory drugs. Adverse Drug Reactions Advisory Committee.
    The Medical journal of Australia, 1998, Sep-07, Volume: 169, Issue:5

    Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Australia; Diclofe

1998
Indomethacin attenuates the cerebral blood flow response to hypotension in late-gestation fetal sheep.
    The American journal of physiology, 1999, Volume: 277, Issue:5

    Topics: Adrenocorticotropic Hormone; Animals; Arginine Vasopressin; Blood Pressure; Cerebrovascular Circulat

1999
Polyhydramnios as a sign of fetal pseudohypoaldosteronism.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2000, Volume: 69, Issue:1

    Topics: Adult; Amniocentesis; Cesarean Section; Female; Fetal Diseases; Follow-Up Studies; Gestational Age;

2000
Radiofrequency ablation of human fetal sacrococcygeal teratoma.
    American journal of obstetrics and gynecology, 2001, Volume: 184, Issue:3

    Topics: Adult; Catheter Ablation; Electrocardiography; Fatal Outcome; Female; Fetal Diseases; Humans; Indome

2001
Tricuspid regurgitation in a pair of twins at birth secondary to antenatal indomethacin.
    Indian pediatrics, 2001, Volume: 38, Issue:10

    Topics: Diseases in Twins; Female; Fetal Diseases; Humans; Indomethacin; Polyhydramnios; Pregnancy; Tocolyti

2001
Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem.
    American journal of obstetrics and gynecology, 1979, Sep-15, Volume: 135, Issue:2

    Topics: Animals; Brain Diseases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arterio

1979
Constriction of the fetal ductus arteriosus after administration of indomethacin to the pregnant ewe.
    The Journal of pediatrics, 1979, Volume: 94, Issue:4

    Topics: Animals; Blood Pressure; Ductus Arteriosus; Female; Fetal Diseases; Hypertension, Pulmonary; Indomet

1979
[Problems of rheumatic therapy in pregnancy (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1976, Oct-08, Volume: 118, Issue:41

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Azathioprine; Chloroquine; Female; Fetal Diseases

1976
[The neonatal form of Bartter's syndrome: current findings in etiology and physiopathology].
    Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1992, Volume: 54, Issue:3

    Topics: Bartter Syndrome; Calcium; Fetal Diseases; Fluid Therapy; Humans; Indomethacin; Infant; Infant, Newb

1992
[Indomethacin in threatening premature labor. Fetal and neonatal cardiovascular effects].
    Ginecologia y obstetricia de Mexico, 1992, Volume: 60

    Topics: Cardiovascular Diseases; Female; Fetal Diseases; Humans; Hypertension, Pulmonary; Indomethacin; Infa

1992
Cocaine and indomethacin: fetal anuria, neonatal edema, and gastrointestinal bleeding.
    Obstetrics and gynecology, 1991, Volume: 78, Issue:3 Pt 2

    Topics: Adult; Anuria; Cocaine; Drug Synergism; Female; Fetal Diseases; Gastrointestinal Hemorrhage; Humans;

1991
Indomethacin for preterm labor: fetal toxicity in a dizygotic twin gestation.
    Obstetrics and gynecology, 1991, Volume: 78, Issue:5 Pt 2

    Topics: Abnormalities, Drug-Induced; Adult; Diseases in Twins; Drug Monitoring; Ductus Arteriosus; Female; F

1991
Right ventricular concentric hypertrophy and left ventricular dilatation by ductal constriction in fetal rats.
    Circulation research, 1989, Volume: 64, Issue:6

    Topics: Animals; Cardiomegaly; Constriction, Pathologic; Dilatation, Pathologic; Ductus Arteriosus; Female;

1989
Indomethacin in the treatment of premature labor. Effects on the fetal ductus arteriosus.
    The New England journal of medicine, 1988, Aug-11, Volume: 319, Issue:6

    Topics: Adolescent; Adult; Constriction, Pathologic; Dose-Response Relationship, Drug; Ductus Arteriosus; Ec

1988
Detection and quantitation of constriction of the fetal ductus arteriosus by Doppler echocardiography.
    Circulation, 1987, Volume: 75, Issue:2

    Topics: Animals; Constriction, Pathologic; Ductus Arteriosus; Echocardiography; Female; Fetal Diseases; Huma

1987
Inhibitors of prostaglandin synthesis during pregnancy. 1. Embryopathic activity of indomethacin in mice.
    Anatomischer Anzeiger, 1974, Volume: 136, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetal Diseases; Fetus; Gestational Age; I

1974
Inhibitors of prostaglandin synthesis during pregnancy. 2. The effects of indomethacin in pregnant rats.
    Anatomischer Anzeiger, 1974, Volume: 136, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetal Diseases; Fetus; Growth; Indomethac

1974
The effects of an inhibitor of prostaglandin synthesis (indomethacin) on ovulation, pregnancy, and pseudopregnancy in the rabbit.
    Prostaglandins, 1972, Volume: 1, Issue:2

    Topics: Animals; Chorionic Gonadotropin; Coitus; Corpus Luteum; Depression, Chemical; Female; Fetal Diseases

1972