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indomethacin and Embolism, Pulmonary

indomethacin has been researched along with Embolism, Pulmonary in 24 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"5 U/g) and indomethacin (200 micrograms/g) had no significant effect in prolonging the occlusion time or in reducing ADP-induced pulmonary embolism in mice."3.69In vivo antithrombotic effect of triflavin, an Arg-Gly-Asp containing peptide on platelet plug formation in mesenteric microvessels of mice. ( Chao, SH; Huang, TF; Sheu, JR; Yen, MH, 1994)
"Pretreatment with indomethacin, isoproterenol, or nifedipine significantly reduced post-air-embolism lung water content to 85."1.30Pharmacologic modulation of pulmonary vascular permeability during air embolism. ( Huang, KL; Lin, YC, 1997)
"Pretreatment with indomethacin attenuated the increase in Kf after 65% triolein but not after 99% triolein."1.30Triolein-induced pulmonary embolization and increased microvascular permeability in isolated perfused rat lungs. ( Kuwagata, Y; Nakata, Y; Sugimoto, H; Tanaka, H; Yoshioka, T, 1999)
"The role of reperfusion injury in the progression to necrosis in pulmonary embolism was evaluated."1.28Reperfusion after a two-hour period of pulmonary artery occlusion causes pulmonary necrosis. ( Mori, I; Murata, T; Nakazawa, H; Ohta, Y; Yamabayashi, H, 1992)
"We conclude that, in experimental pulmonary embolism, structurally different cyclooxygenase inhibitors aggravate pulmonary hypertension and deteriorate gas exchange by an altered distribution of VA/Q essentially to lung units with a higher than normal VA/Q."1.28Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism. ( Delcroix, M; Leeman, M; Lejeune, P; Melot, C; Naeije, R, 1992)
"Imidazole pretreatment prevented a rise of TxB(2), but not 6-keto-PGF(1alpha); indomethacin blocked both."1.26Thromboxane mediation of cardiopulmonary effects of embolism. ( Hechtman, HB; Krausz, MM; Levine, L; Shepro, D; Utsonomiya, T, 1982)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199015 (62.50)18.7374
1990's9 (37.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Utsonomiya, T1
Krausz, MM1
Levine, L2
Shepro, D3
Hechtman, HB3
Huval, WV1
Mathieson, MA1
Stemp, LI1
Valeri, CR1
Hirose, T1
Aoki, E1
Ishibashi, M1
Domae, M1
Ikeda, T1
Tanaka, K1
Utsunomiya, T1
Krausz, MK1
Dunham, B1
Todd, MH1
Cragg, DB1
Forrest, JB1
Ali, M1
McDonald, JW1
Clay, TP1
Hughes, JM1
Carpi, A1
Del Basso, P1
Petrusewicz, J1
Turowski, M1
Foks, H1
Pilarski, B1
Kaliszan, R1
Sheu, JR1
Chao, SH1
Yen, MH1
Huang, TF1
Yamaguchi, K1
Mori, M1
Kawai, A1
Asano, K1
Takasugi, T1
Umeda, A1
Kawashiro, T1
Yokoyama, T1
Kumari, R1
Dikshit, M1
Srimal, RC2
Huang, KL1
Lin, YC1
Nakata, Y1
Tanaka, H1
Kuwagata, Y1
Yoshioka, T1
Sugimoto, H1
Weidner, WJ1
Lindquist, O1
Saldeen, T1
Sandler, H1
Murata, T1
Nakazawa, H1
Mori, I1
Ohta, Y1
Yamabayashi, H1
Delcroix, M1
Melot, C1
Lejeune, P1
Leeman, M1
Naeije, R1
Armstrong, DJ1
Kay, IS1
Srivastava, R1
Mishra, A1
Pratap, R1
Bhakuni, DS1
Johnson, A1
Malik, AB1
Yamamoto, M1
Sakata, H1
Marsh, FP1
Almeyda, JR1
Levy, IS1
Nakano, J1
McCloy, RB1

Reviews

1 review available for indomethacin and Embolism, Pulmonary

ArticleYear
Prostaglandin and thromboxane mediation of cardiopulmonary failure.
    The Surgical clinics of North America, 1983, Volume: 63, Issue:2

    Topics: Animals; Arachidonic Acids; Cardiac Output; Cell Membrane; Cell Membrane Permeability; Dogs; Fibrino

1983

Other Studies

23 other studies available for indomethacin and Embolism, Pulmonary

ArticleYear
Thromboxane mediation of cardiopulmonary effects of embolism.
    The Journal of clinical investigation, 1982, Volume: 70, Issue:2

    Topics: Animals; Dogs; Epoprostenol; Female; Heart; Imidazoles; Indomethacin; Ketoconazole; Male; Piperazine

1982
The effect of prostacyclin on increased hydraulic conductivity of pulmonary exchange vessels following microembolization in dogs.
    Microvascular research, 1983, Volume: 26, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Permeability; Dogs; Epoprostenol; Female; Hemodynam

1983
Circulating negative inotropic agent(s) following pulmonary embolism.
    Surgery, 1982, Volume: 91, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcium-Transporting ATPases; Cardiac Output; Dogs; Epoproste

1982
The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs.
    Thrombosis research, 1983, Apr-01, Volume: 30, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Anesthesia, General; Animals; Aspirin; Hypotension; Indomethacin; Lung

1983
The role of prostaglandins in the bronchoconstriction induced by pulmonary micro-embolism in the guinea-pig.
    The Journal of physiology, 1980, Volume: 308

    Topics: Airway Resistance; Animals; Barium Sulfate; Blood Platelets; Guinea Pigs; Indomethacin; Lung Complia

1980
[Interaction between heart and lung functions in a heart-lung preparation: rheological aspects].
    Vestnik Akademii meditsinskikh nauk SSSR, 1980, Issue:1

    Topics: Animals; Guinea Pigs; Heart; Heart Failure; In Vitro Techniques; Indomethacin; Lung; Platelet Aggreg

1980
Comparative studies of antiplatelet activity of nonsteroidal antiinflammatory drugs and new pyrazine CH- and NH-acids.
    Life sciences, 1995, Volume: 56, Issue:9

    Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Epinephrine; Fibr

1995
In vivo antithrombotic effect of triflavin, an Arg-Gly-Asp containing peptide on platelet plug formation in mesenteric microvessels of mice.
    Thrombosis and haemostasis, 1994, Volume: 72, Issue:4

    Topics: Acute Disease; Adenosine Diphosphate; Alprostadil; Amino Acid Sequence; Animals; Blood Pressure; End

1994
Regulation of blood flow in pulmonary microcirculation by vasoactive arachidonic acid metabolites--analysis in acute lung injury.
    Advances in experimental medicine and biology, 1994, Volume: 345

    Topics: Animals; Arachidonic Acids; Disease Models, Animal; Dogs; Embolism, Fat; Epoprostenol; Female; Hypox

1994
Free radical scavenging mechanisms during pulmonary thromboembolism in rats.
    Thrombosis research, 1993, Jan-01, Volume: 69, Issue:1

    Topics: Allopurinol; Animals; Blood Platelets; Catalase; Free Radical Scavengers; Indomethacin; Lung; Male;

1993
Pharmacologic modulation of pulmonary vascular permeability during air embolism.
    Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 1997,Winter, Volume: 24, Issue:4

    Topics: Animals; Capillary Permeability; Cyclooxygenase Inhibitors; Hypertension, Pulmonary; Indomethacin; I

1997
Triolein-induced pulmonary embolization and increased microvascular permeability in isolated perfused rat lungs.
    The Journal of trauma, 1999, Volume: 47, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Capillary Permeability; Cyclooxygenase Inhibit

1999
Effects of indomethacin on pulmonary hemodynamics and extravascular lung water in sheep after pulmonary microembolism.
    Prostaglandins and medicine, 1979, Volume: 3, Issue:2

    Topics: Animals; Body Water; Female; Hemodynamics; Hypertension, Pulmonary; Indomethacin; Lung; Prostaglandi

1979
Pulmonary damage following pulmonary microembolism in the dog. Effect of various types of treatment.
    Acta chirurgica Scandinavica, 1976, Volume: 142, Issue:1

    Topics: Animals; Aspirin; Calcium; Cyclohexanecarboxylic Acids; Dogs; Female; Indomethacin; Lung; Male; Meth

1976
Reperfusion after a two-hour period of pulmonary artery occlusion causes pulmonary necrosis.
    The American review of respiratory disease, 1992, Volume: 146, Issue:4

    Topics: Animals; Constriction; Indomethacin; Lung; Male; Pulmonary Alveoli; Pulmonary Artery; Pulmonary Embo

1992
Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism.
    The American review of respiratory disease, 1992, Volume: 145, Issue:4 Pt 1

    Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dogs; Hypertension, Pulmonary; Indomethacin; Pulmonary

1992
5-Hydroxytryptamine mediates the post-embolic increase in respiratory rate in anaesthetized rabbits.
    Experimental physiology, 1990, Volume: 75, Issue:4

    Topics: Analysis of Variance; Animals; Blood Pressure; Heart Rate; Indomethacin; Platelet Count; Pulmonary E

1990
Antithrombotic effect of thiopurinol.
    Thrombosis research, 1989, Jun-15, Volume: 54, Issue:6

    Topics: Allopurinol; Animals; Blood Pressure; Cats; Extracorporeal Circulation; Free Radicals; Heart Rate; I

1989
Pulmonary transvascular fluid and protein exchange after thrombin-induced microembolism. Differential effects of cyclooxygenase inhibitors.
    The American review of respiratory disease, 1985, Volume: 132, Issue:1

    Topics: Animals; Blood Proteins; Capillary Permeability; Cyclooxygenase Inhibitors; Dose-Response Relationsh

1985
Pathology of experimental pulmonary bone marrow embolism. I. Initial lesions of the rabbit lung after intravenous infusion of allogeneic bone marrow with special reference to its pathogenesis.
    Acta pathologica japonica, 1985, Volume: 35, Issue:1

    Topics: Animals; Bone Marrow; Capillary Permeability; Diphenhydramine; Embolism, Fat; Endothelium; Female; I

1985
[Pulmonary thromboembolism of rabbits receiving an intravenous single infusion of autologous thrombus with special reference to the pathogenesis of initial lesions].
    Nihon Kyobu Shikkan Gakkai zasshi, 1985, Volume: 23, Issue:10

    Topics: Animals; Female; Indomethacin; Injections, Intravenous; Methylprednisolone; Pulmonary Embolism; Rabb

1985
Non-thrombocytopenic purpura and acute glomerulonephritis after indomethacin therapy.
    Annals of the rheumatic diseases, 1971, Volume: 30, Issue:5

    Topics: Aged; Drug Hypersensitivity; Female; Glomerulonephritis; Humans; Indomethacin; Kidney; Male; Middle

1971
Effects of indomethacin on the pulmonary vascular and air way resistance responses to pulmonary microembolization.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 143, Issue:1

    Topics: Airway Resistance; Animals; Barium Sulfate; Blood Pressure; Dogs; Indomethacin; Prostaglandins; Pulm

1973