indomethacin has been researched along with Embolism, Pulmonary in 24 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 U/g) and indomethacin (200 micrograms/g) had no significant effect in prolonging the occlusion time or in reducing ADP-induced pulmonary embolism in mice." | 3.69 | In vivo antithrombotic effect of triflavin, an Arg-Gly-Asp containing peptide on platelet plug formation in mesenteric microvessels of mice. ( Chao, SH; Huang, TF; Sheu, JR; Yen, MH, 1994) |
| "Pretreatment with indomethacin, isoproterenol, or nifedipine significantly reduced post-air-embolism lung water content to 85." | 1.30 | Pharmacologic modulation of pulmonary vascular permeability during air embolism. ( Huang, KL; Lin, YC, 1997) |
| "Pretreatment with indomethacin attenuated the increase in Kf after 65% triolein but not after 99% triolein." | 1.30 | Triolein-induced pulmonary embolization and increased microvascular permeability in isolated perfused rat lungs. ( Kuwagata, Y; Nakata, Y; Sugimoto, H; Tanaka, H; Yoshioka, T, 1999) |
| "The role of reperfusion injury in the progression to necrosis in pulmonary embolism was evaluated." | 1.28 | Reperfusion after a two-hour period of pulmonary artery occlusion causes pulmonary necrosis. ( Mori, I; Murata, T; Nakazawa, H; Ohta, Y; Yamabayashi, H, 1992) |
| "We conclude that, in experimental pulmonary embolism, structurally different cyclooxygenase inhibitors aggravate pulmonary hypertension and deteriorate gas exchange by an altered distribution of VA/Q essentially to lung units with a higher than normal VA/Q." | 1.28 | Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism. ( Delcroix, M; Leeman, M; Lejeune, P; Melot, C; Naeije, R, 1992) |
| "Imidazole pretreatment prevented a rise of TxB(2), but not 6-keto-PGF(1alpha); indomethacin blocked both." | 1.26 | Thromboxane mediation of cardiopulmonary effects of embolism. ( Hechtman, HB; Krausz, MM; Levine, L; Shepro, D; Utsonomiya, T, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (62.50) | 18.7374 |
| 1990's | 9 (37.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Utsonomiya, T | 1 |
| Krausz, MM | 1 |
| Levine, L | 2 |
| Shepro, D | 3 |
| Hechtman, HB | 3 |
| Huval, WV | 1 |
| Mathieson, MA | 1 |
| Stemp, LI | 1 |
| Valeri, CR | 1 |
| Hirose, T | 1 |
| Aoki, E | 1 |
| Ishibashi, M | 1 |
| Domae, M | 1 |
| Ikeda, T | 1 |
| Tanaka, K | 1 |
| Utsunomiya, T | 1 |
| Krausz, MK | 1 |
| Dunham, B | 1 |
| Todd, MH | 1 |
| Cragg, DB | 1 |
| Forrest, JB | 1 |
| Ali, M | 1 |
| McDonald, JW | 1 |
| Clay, TP | 1 |
| Hughes, JM | 1 |
| Carpi, A | 1 |
| Del Basso, P | 1 |
| Petrusewicz, J | 1 |
| Turowski, M | 1 |
| Foks, H | 1 |
| Pilarski, B | 1 |
| Kaliszan, R | 1 |
| Sheu, JR | 1 |
| Chao, SH | 1 |
| Yen, MH | 1 |
| Huang, TF | 1 |
| Yamaguchi, K | 1 |
| Mori, M | 1 |
| Kawai, A | 1 |
| Asano, K | 1 |
| Takasugi, T | 1 |
| Umeda, A | 1 |
| Kawashiro, T | 1 |
| Yokoyama, T | 1 |
| Kumari, R | 1 |
| Dikshit, M | 1 |
| Srimal, RC | 2 |
| Huang, KL | 1 |
| Lin, YC | 1 |
| Nakata, Y | 1 |
| Tanaka, H | 1 |
| Kuwagata, Y | 1 |
| Yoshioka, T | 1 |
| Sugimoto, H | 1 |
| Weidner, WJ | 1 |
| Lindquist, O | 1 |
| Saldeen, T | 1 |
| Sandler, H | 1 |
| Murata, T | 1 |
| Nakazawa, H | 1 |
| Mori, I | 1 |
| Ohta, Y | 1 |
| Yamabayashi, H | 1 |
| Delcroix, M | 1 |
| Melot, C | 1 |
| Lejeune, P | 1 |
| Leeman, M | 1 |
| Naeije, R | 1 |
| Armstrong, DJ | 1 |
| Kay, IS | 1 |
| Srivastava, R | 1 |
| Mishra, A | 1 |
| Pratap, R | 1 |
| Bhakuni, DS | 1 |
| Johnson, A | 1 |
| Malik, AB | 1 |
| Yamamoto, M | 1 |
| Sakata, H | 1 |
| Marsh, FP | 1 |
| Almeyda, JR | 1 |
| Levy, IS | 1 |
| Nakano, J | 1 |
| McCloy, RB | 1 |
1 review available for indomethacin and Embolism, Pulmonary
| Article | Year |
|---|---|
Prostaglandin and thromboxane mediation of cardiopulmonary failure.
Topics: Animals; Arachidonic Acids; Cardiac Output; Cell Membrane; Cell Membrane Permeability; Dogs; Fibrino | 1983 |
23 other studies available for indomethacin and Embolism, Pulmonary
| Article | Year |
|---|---|
Thromboxane mediation of cardiopulmonary effects of embolism.
Topics: Animals; Dogs; Epoprostenol; Female; Heart; Imidazoles; Indomethacin; Ketoconazole; Male; Piperazine | 1982 |
The effect of prostacyclin on increased hydraulic conductivity of pulmonary exchange vessels following microembolization in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capillary Permeability; Dogs; Epoprostenol; Female; Hemodynam | 1983 |
Circulating negative inotropic agent(s) following pulmonary embolism.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcium-Transporting ATPases; Cardiac Output; Dogs; Epoproste | 1982 |
The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs.
Topics: 6-Ketoprostaglandin F1 alpha; Anesthesia, General; Animals; Aspirin; Hypotension; Indomethacin; Lung | 1983 |
The role of prostaglandins in the bronchoconstriction induced by pulmonary micro-embolism in the guinea-pig.
Topics: Airway Resistance; Animals; Barium Sulfate; Blood Platelets; Guinea Pigs; Indomethacin; Lung Complia | 1980 |
[Interaction between heart and lung functions in a heart-lung preparation: rheological aspects].
Topics: Animals; Guinea Pigs; Heart; Heart Failure; In Vitro Techniques; Indomethacin; Lung; Platelet Aggreg | 1980 |
Comparative studies of antiplatelet activity of nonsteroidal antiinflammatory drugs and new pyrazine CH- and NH-acids.
Topics: Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Epinephrine; Fibr | 1995 |
In vivo antithrombotic effect of triflavin, an Arg-Gly-Asp containing peptide on platelet plug formation in mesenteric microvessels of mice.
Topics: Acute Disease; Adenosine Diphosphate; Alprostadil; Amino Acid Sequence; Animals; Blood Pressure; End | 1994 |
Regulation of blood flow in pulmonary microcirculation by vasoactive arachidonic acid metabolites--analysis in acute lung injury.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Dogs; Embolism, Fat; Epoprostenol; Female; Hypox | 1994 |
Free radical scavenging mechanisms during pulmonary thromboembolism in rats.
Topics: Allopurinol; Animals; Blood Platelets; Catalase; Free Radical Scavengers; Indomethacin; Lung; Male; | 1993 |
Pharmacologic modulation of pulmonary vascular permeability during air embolism.
Topics: Animals; Capillary Permeability; Cyclooxygenase Inhibitors; Hypertension, Pulmonary; Indomethacin; I | 1997 |
Triolein-induced pulmonary embolization and increased microvascular permeability in isolated perfused rat lungs.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Capillary Permeability; Cyclooxygenase Inhibit | 1999 |
Effects of indomethacin on pulmonary hemodynamics and extravascular lung water in sheep after pulmonary microembolism.
Topics: Animals; Body Water; Female; Hemodynamics; Hypertension, Pulmonary; Indomethacin; Lung; Prostaglandi | 1979 |
Pulmonary damage following pulmonary microembolism in the dog. Effect of various types of treatment.
Topics: Animals; Aspirin; Calcium; Cyclohexanecarboxylic Acids; Dogs; Female; Indomethacin; Lung; Male; Meth | 1976 |
Reperfusion after a two-hour period of pulmonary artery occlusion causes pulmonary necrosis.
Topics: Animals; Constriction; Indomethacin; Lung; Male; Pulmonary Alveoli; Pulmonary Artery; Pulmonary Embo | 1992 |
Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism.
Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Dogs; Hypertension, Pulmonary; Indomethacin; Pulmonary | 1992 |
5-Hydroxytryptamine mediates the post-embolic increase in respiratory rate in anaesthetized rabbits.
Topics: Analysis of Variance; Animals; Blood Pressure; Heart Rate; Indomethacin; Platelet Count; Pulmonary E | 1990 |
Antithrombotic effect of thiopurinol.
Topics: Allopurinol; Animals; Blood Pressure; Cats; Extracorporeal Circulation; Free Radicals; Heart Rate; I | 1989 |
Pulmonary transvascular fluid and protein exchange after thrombin-induced microembolism. Differential effects of cyclooxygenase inhibitors.
Topics: Animals; Blood Proteins; Capillary Permeability; Cyclooxygenase Inhibitors; Dose-Response Relationsh | 1985 |
Pathology of experimental pulmonary bone marrow embolism. I. Initial lesions of the rabbit lung after intravenous infusion of allogeneic bone marrow with special reference to its pathogenesis.
Topics: Animals; Bone Marrow; Capillary Permeability; Diphenhydramine; Embolism, Fat; Endothelium; Female; I | 1985 |
[Pulmonary thromboembolism of rabbits receiving an intravenous single infusion of autologous thrombus with special reference to the pathogenesis of initial lesions].
Topics: Animals; Female; Indomethacin; Injections, Intravenous; Methylprednisolone; Pulmonary Embolism; Rabb | 1985 |
Non-thrombocytopenic purpura and acute glomerulonephritis after indomethacin therapy.
Topics: Aged; Drug Hypersensitivity; Female; Glomerulonephritis; Humans; Indomethacin; Kidney; Male; Middle | 1971 |
Effects of indomethacin on the pulmonary vascular and air way resistance responses to pulmonary microembolization.
Topics: Airway Resistance; Animals; Barium Sulfate; Blood Pressure; Dogs; Indomethacin; Prostaglandins; Pulm | 1973 |