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indomethacin and Elevated ICP (Intracranial Pressure)

indomethacin has been researched along with Elevated ICP (Intracranial Pressure) in 11 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Research Excerpts

ExcerptRelevanceReference
"This study aimed to (1) determine alterations in intracranial pressure (ICP) and cerebral hemodynamics after an indomethacin (INDO) infusion test and the related association with survival in patients with refractory intracranial hypertension (RICH) secondary to sICH or sTBI and (2) assess the safety profile after INDO."9.16Effects of indomethacin test on intracranial pressure and cerebral hemodynamics in patients with refractory intracranial hypertension: a feasibility study. ( Ainslie, PN; Biestro, A; Di Napoli, M; Godoy, DA; Rabinstein, AA, 2012)
"We found no studies, either completed or ongoing, that assessed the effects of indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury."9.01Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults. ( Baccaro, FG; Ciapponi, A; Escobar Aguilar, G; Garcia Garcia, E; López-Alcalde, J; Martín-Saborido, C; Palermo, MC; Sánchez Martín, CE, 2019)
"A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures."7.81Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015)
" We studied the effects of indomethacin on ICP and cerebral blood flow (CBF) during isoflurane or propofol anesthesia in a sheep model of intracranial hypertension."7.73The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension. ( Cold, GE; Grant, C; Ludbrook, G; Martinez, AM; Rasmussen, M; Upton, RN, 2006)
"The CSF-pressure-lowering effects of indomethacin in seven patients with idiopathic intracranial hypertension and one patient with symptomatic intracranial hypertension due to a non-space-occupying meningioma are reported."7.70Indomethacin reduces CSF pressure in intracranial hypertension. ( Förderreuther, S; Straube, A, 2000)
" The present study reports the effect of indomethacin on four occasions of intracranial hypertension, in a 23-year old previously healthy woman with severe acetaminophen poisoning."7.69Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin. ( Clemmesen, JO; Hansen, BA; Larsen, FS, 1997)
"This study aimed to (1) determine alterations in intracranial pressure (ICP) and cerebral hemodynamics after an indomethacin (INDO) infusion test and the related association with survival in patients with refractory intracranial hypertension (RICH) secondary to sICH or sTBI and (2) assess the safety profile after INDO."5.16Effects of indomethacin test on intracranial pressure and cerebral hemodynamics in patients with refractory intracranial hypertension: a feasibility study. ( Ainslie, PN; Biestro, A; Di Napoli, M; Godoy, DA; Rabinstein, AA, 2012)
"We found no studies, either completed or ongoing, that assessed the effects of indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury."5.01Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults. ( Baccaro, FG; Ciapponi, A; Escobar Aguilar, G; Garcia Garcia, E; López-Alcalde, J; Martín-Saborido, C; Palermo, MC; Sánchez Martín, CE, 2019)
"A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures."3.81Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015)
" We studied the effects of indomethacin on ICP and cerebral blood flow (CBF) during isoflurane or propofol anesthesia in a sheep model of intracranial hypertension."3.73The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension. ( Cold, GE; Grant, C; Ludbrook, G; Martinez, AM; Rasmussen, M; Upton, RN, 2006)
"The CSF-pressure-lowering effects of indomethacin in seven patients with idiopathic intracranial hypertension and one patient with symptomatic intracranial hypertension due to a non-space-occupying meningioma are reported."3.70Indomethacin reduces CSF pressure in intracranial hypertension. ( Förderreuther, S; Straube, A, 2000)
" The present study reports the effect of indomethacin on four occasions of intracranial hypertension, in a 23-year old previously healthy woman with severe acetaminophen poisoning."3.69Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin. ( Clemmesen, JO; Hansen, BA; Larsen, FS, 1997)
"Indomethacin is a non-selective cyclooxygenase inhibitor."2.43Treatment of elevated intracranial pressure with indomethacin: friend or foe? ( Rasmussen, M, 2005)
"Indomethacin (IND) is a non-steroidal anti-inflammatory agent with unique effects on cerebral blood flow physiology which may be of benefit in reducing elevated ICP in TBI patients."2.40Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients. ( Rhoney, DH; Slavik, RS, 1999)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's4 (36.36)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Martín-Saborido, C1
López-Alcalde, J1
Ciapponi, A1
Sánchez Martín, CE1
Garcia Garcia, E1
Escobar Aguilar, G1
Palermo, MC1
Baccaro, FG1
Godoy, DA2
Alvarez, E1
Manzi, R1
Piñero, G1
Di Napoli, M2
Sader, N1
Zeiler, FA1
Gillman, LM1
West, M1
Kazina, CJ1
Jones, MC1
Lasak-Myall, T1
Abdelhak, TM1
Varelas, PN1
Rabinstein, AA1
Biestro, A1
Ainslie, PN1
Rasmussen, M2
Raghavan, M1
Marik, PE1
Upton, RN1
Grant, C1
Martinez, AM1
Cold, GE1
Ludbrook, G1
Clemmesen, JO1
Hansen, BA1
Larsen, FS1
Slavik, RS1
Rhoney, DH1
Förderreuther, S1
Straube, A1

Reviews

5 reviews available for indomethacin and Elevated ICP (Intracranial Pressure)

ArticleYear
Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
    The Cochrane database of systematic reviews, 2019, 11-22, Volume: 2019, Issue:11

    Topics: Brain Injuries, Traumatic; Cardiovascular Agents; Humans; Indomethacin; Intracranial Hypertension; I

2019
Indomethacin for control of ICP.
    Neurocritical care, 2015, Volume: 22, Issue:3

    Topics: Brain Injuries; Cardiovascular Agents; Humans; Indomethacin; Intracranial Hypertension

2015
Treatment of elevated intracranial pressure with indomethacin: friend or foe?
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:3

    Topics: Animals; Brain; Brain Injuries; Cerebrovascular Circulation; Craniotomy; Cyclooxygenase Inhibitors;

2005
Therapy of intracranial hypertension in patients with fulminant hepatic failure.
    Neurocritical care, 2006, Volume: 4, Issue:2

    Topics: Ammonia; Anesthetics, Intravenous; Brain; Cardiovascular Agents; Cerebrovascular Circulation; Electr

2006
Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients.
    Neurological research, 1999, Volume: 21, Issue:5

    Topics: Adult; Animals; Barbiturates; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Cerebrovascular

1999

Trials

1 trial available for indomethacin and Elevated ICP (Intracranial Pressure)

ArticleYear
Effects of indomethacin test on intracranial pressure and cerebral hemodynamics in patients with refractory intracranial hypertension: a feasibility study.
    Neurosurgery, 2012, Volume: 71, Issue:2

    Topics: Adult; Aged; Antihypertensive Agents; Cardiovascular Agents; Cerebrovascular Circulation; Chronic Di

2012

Other Studies

5 other studies available for indomethacin and Elevated ICP (Intracranial Pressure)

ArticleYear
The physiologic effects of indomethacin test on CPP and ICP in severe traumatic brain injury (sTBI).
    Neurocritical care, 2014, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Aged; Brain Injuries; Cardiovascular Agents; Cerebrovascular Circulation; Glasgow

2014
Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2015, Jun-15, Volume: 72, Issue:12

    Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injur

2015
The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension.
    Anesthesia and analgesia, 2006, Volume: 102, Issue:6

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Pressure;

2006
Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin.
    Hepatology (Baltimore, Md.), 1997, Volume: 26, Issue:6

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Arteries; Fatal Outcome; Fem

1997
Indomethacin reduces CSF pressure in intracranial hypertension.
    Neurology, 2000, Oct-10, Volume: 55, Issue:7

    Topics: Adult; Cerebrospinal Fluid Pressure; Female; Humans; Indomethacin; Intracranial Hypertension; Male;

2000