indomethacin has been researched along with Elevated ICP (Intracranial Pressure) in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to (1) determine alterations in intracranial pressure (ICP) and cerebral hemodynamics after an indomethacin (INDO) infusion test and the related association with survival in patients with refractory intracranial hypertension (RICH) secondary to sICH or sTBI and (2) assess the safety profile after INDO." | 9.16 | Effects of indomethacin test on intracranial pressure and cerebral hemodynamics in patients with refractory intracranial hypertension: a feasibility study. ( Ainslie, PN; Biestro, A; Di Napoli, M; Godoy, DA; Rabinstein, AA, 2012) |
| "We found no studies, either completed or ongoing, that assessed the effects of indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury." | 9.01 | Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults. ( Baccaro, FG; Ciapponi, A; Escobar Aguilar, G; Garcia Garcia, E; López-Alcalde, J; Martín-Saborido, C; Palermo, MC; Sánchez Martín, CE, 2019) |
| "A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures." | 7.81 | Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015) |
| " We studied the effects of indomethacin on ICP and cerebral blood flow (CBF) during isoflurane or propofol anesthesia in a sheep model of intracranial hypertension." | 7.73 | The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension. ( Cold, GE; Grant, C; Ludbrook, G; Martinez, AM; Rasmussen, M; Upton, RN, 2006) |
| "The CSF-pressure-lowering effects of indomethacin in seven patients with idiopathic intracranial hypertension and one patient with symptomatic intracranial hypertension due to a non-space-occupying meningioma are reported." | 7.70 | Indomethacin reduces CSF pressure in intracranial hypertension. ( Förderreuther, S; Straube, A, 2000) |
| " The present study reports the effect of indomethacin on four occasions of intracranial hypertension, in a 23-year old previously healthy woman with severe acetaminophen poisoning." | 7.69 | Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin. ( Clemmesen, JO; Hansen, BA; Larsen, FS, 1997) |
| "This study aimed to (1) determine alterations in intracranial pressure (ICP) and cerebral hemodynamics after an indomethacin (INDO) infusion test and the related association with survival in patients with refractory intracranial hypertension (RICH) secondary to sICH or sTBI and (2) assess the safety profile after INDO." | 5.16 | Effects of indomethacin test on intracranial pressure and cerebral hemodynamics in patients with refractory intracranial hypertension: a feasibility study. ( Ainslie, PN; Biestro, A; Di Napoli, M; Godoy, DA; Rabinstein, AA, 2012) |
| "We found no studies, either completed or ongoing, that assessed the effects of indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury." | 5.01 | Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults. ( Baccaro, FG; Ciapponi, A; Escobar Aguilar, G; Garcia Garcia, E; López-Alcalde, J; Martín-Saborido, C; Palermo, MC; Sánchez Martín, CE, 2019) |
| "A 42-year-old woman receiving intensive care for fulminant hepatic failure secondary to acetaminophen toxicity developed cerebral edema and intracranial hypertension refractory to standard pharmacotherapy and respiratory support measures." | 3.81 | Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure. ( Abdelhak, TM; Jones, MC; Lasak-Myall, T; Varelas, PN, 2015) |
| " We studied the effects of indomethacin on ICP and cerebral blood flow (CBF) during isoflurane or propofol anesthesia in a sheep model of intracranial hypertension." | 3.73 | The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension. ( Cold, GE; Grant, C; Ludbrook, G; Martinez, AM; Rasmussen, M; Upton, RN, 2006) |
| "The CSF-pressure-lowering effects of indomethacin in seven patients with idiopathic intracranial hypertension and one patient with symptomatic intracranial hypertension due to a non-space-occupying meningioma are reported." | 3.70 | Indomethacin reduces CSF pressure in intracranial hypertension. ( Förderreuther, S; Straube, A, 2000) |
| " The present study reports the effect of indomethacin on four occasions of intracranial hypertension, in a 23-year old previously healthy woman with severe acetaminophen poisoning." | 3.69 | Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin. ( Clemmesen, JO; Hansen, BA; Larsen, FS, 1997) |
| "Indomethacin is a non-selective cyclooxygenase inhibitor." | 2.43 | Treatment of elevated intracranial pressure with indomethacin: friend or foe? ( Rasmussen, M, 2005) |
| "Indomethacin (IND) is a non-steroidal anti-inflammatory agent with unique effects on cerebral blood flow physiology which may be of benefit in reducing elevated ICP in TBI patients." | 2.40 | Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients. ( Rhoney, DH; Slavik, RS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martín-Saborido, C | 1 |
| López-Alcalde, J | 1 |
| Ciapponi, A | 1 |
| Sánchez Martín, CE | 1 |
| Garcia Garcia, E | 1 |
| Escobar Aguilar, G | 1 |
| Palermo, MC | 1 |
| Baccaro, FG | 1 |
| Godoy, DA | 2 |
| Alvarez, E | 1 |
| Manzi, R | 1 |
| Piñero, G | 1 |
| Di Napoli, M | 2 |
| Sader, N | 1 |
| Zeiler, FA | 1 |
| Gillman, LM | 1 |
| West, M | 1 |
| Kazina, CJ | 1 |
| Jones, MC | 1 |
| Lasak-Myall, T | 1 |
| Abdelhak, TM | 1 |
| Varelas, PN | 1 |
| Rabinstein, AA | 1 |
| Biestro, A | 1 |
| Ainslie, PN | 1 |
| Rasmussen, M | 2 |
| Raghavan, M | 1 |
| Marik, PE | 1 |
| Upton, RN | 1 |
| Grant, C | 1 |
| Martinez, AM | 1 |
| Cold, GE | 1 |
| Ludbrook, G | 1 |
| Clemmesen, JO | 1 |
| Hansen, BA | 1 |
| Larsen, FS | 1 |
| Slavik, RS | 1 |
| Rhoney, DH | 1 |
| Förderreuther, S | 1 |
| Straube, A | 1 |
5 reviews available for indomethacin and Elevated ICP (Intracranial Pressure)
| Article | Year |
|---|---|
Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
Topics: Brain Injuries, Traumatic; Cardiovascular Agents; Humans; Indomethacin; Intracranial Hypertension; I | 2019 |
Indomethacin for control of ICP.
Topics: Brain Injuries; Cardiovascular Agents; Humans; Indomethacin; Intracranial Hypertension | 2015 |
Treatment of elevated intracranial pressure with indomethacin: friend or foe?
Topics: Animals; Brain; Brain Injuries; Cerebrovascular Circulation; Craniotomy; Cyclooxygenase Inhibitors; | 2005 |
Therapy of intracranial hypertension in patients with fulminant hepatic failure.
Topics: Ammonia; Anesthetics, Intravenous; Brain; Cardiovascular Agents; Cerebrovascular Circulation; Electr | 2006 |
Indomethacin: a review of its cerebral blood flow effects and potential use for controlling intracranial pressure in traumatic brain injury patients.
Topics: Adult; Animals; Barbiturates; Birth Injuries; Brain Damage, Chronic; Brain Injuries; Cerebrovascular | 1999 |
1 trial available for indomethacin and Elevated ICP (Intracranial Pressure)
| Article | Year |
|---|---|
Effects of indomethacin test on intracranial pressure and cerebral hemodynamics in patients with refractory intracranial hypertension: a feasibility study.
Topics: Adult; Aged; Antihypertensive Agents; Cardiovascular Agents; Cerebrovascular Circulation; Chronic Di | 2012 |
5 other studies available for indomethacin and Elevated ICP (Intracranial Pressure)
| Article | Year |
|---|---|
The physiologic effects of indomethacin test on CPP and ICP in severe traumatic brain injury (sTBI).
Topics: Adolescent; Adult; Aged; Brain Injuries; Cardiovascular Agents; Cerebrovascular Circulation; Glasgow | 2014 |
Indomethacin for treatment of refractory intracranial hypertension secondary to acute liver failure.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injur | 2015 |
The effects of indomethacin on intracranial pressure and cerebral hemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Pressure; | 2006 |
Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Arteries; Fatal Outcome; Fem | 1997 |
Indomethacin reduces CSF pressure in intracranial hypertension.
Topics: Adult; Cerebrospinal Fluid Pressure; Female; Humans; Indomethacin; Intracranial Hypertension; Male; | 2000 |